NR2F6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.83435696
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.83435696
3L-phenylalanine metabolic process (GO:0006558)6.75620008
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.75620008
5aromatic amino acid family catabolic process (GO:0009074)6.02023694
6glyoxylate metabolic process (GO:0046487)5.72557076
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.59276195
8kynurenine metabolic process (GO:0070189)5.44559041
9cysteine metabolic process (GO:0006534)5.39954259
10tryptophan catabolic process (GO:0006569)5.37524552
11indole-containing compound catabolic process (GO:0042436)5.37524552
12indolalkylamine catabolic process (GO:0046218)5.37524552
13sulfur amino acid catabolic process (GO:0000098)5.27818089
14negative regulation of fibrinolysis (GO:0051918)5.12352089
15bile acid biosynthetic process (GO:0006699)5.12158121
16lysine catabolic process (GO:0006554)5.11640354
17lysine metabolic process (GO:0006553)5.11640354
18alpha-linolenic acid metabolic process (GO:0036109)5.09610542
19tryptophan metabolic process (GO:0006568)5.06402809
20urea cycle (GO:0000050)4.99473299
21urea metabolic process (GO:0019627)4.99473299
22protein carboxylation (GO:0018214)4.88014222
23peptidyl-glutamic acid carboxylation (GO:0017187)4.88014222
24serine family amino acid catabolic process (GO:0009071)4.87216247
25high-density lipoprotein particle remodeling (GO:0034375)4.80963620
26regulation of fibrinolysis (GO:0051917)4.74846258
27homocysteine metabolic process (GO:0050667)4.69931138
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.64966056
29nitrogen cycle metabolic process (GO:0071941)4.61083725
30complement activation, alternative pathway (GO:0006957)4.49585395
31regulation of protein activation cascade (GO:2000257)4.45796497
32regulation of triglyceride catabolic process (GO:0010896)4.42497744
33amino-acid betaine metabolic process (GO:0006577)4.41749477
34aromatic amino acid family metabolic process (GO:0009072)4.38140117
35cellular ketone body metabolic process (GO:0046950)4.34394437
36bile acid metabolic process (GO:0008206)4.33615317
37negative regulation of cholesterol transport (GO:0032375)4.32177677
38negative regulation of sterol transport (GO:0032372)4.32177677
39reverse cholesterol transport (GO:0043691)4.27888098
40alpha-amino acid catabolic process (GO:1901606)4.27379107
41proline biosynthetic process (GO:0006561)4.25949770
42ribosomal small subunit biogenesis (GO:0042274)4.25538977
43cellular modified amino acid catabolic process (GO:0042219)4.21044342
44regulation of cholesterol esterification (GO:0010872)4.18027524
45regulation of complement activation (GO:0030449)4.17553520
46acylglycerol homeostasis (GO:0055090)4.15588857
47triglyceride homeostasis (GO:0070328)4.15588857
48regulation of cholesterol homeostasis (GO:2000188)4.12443770
49tyrosine metabolic process (GO:0006570)4.09942411
50glycine metabolic process (GO:0006544)4.09264756
51protein-lipid complex remodeling (GO:0034368)4.08952788
52macromolecular complex remodeling (GO:0034367)4.08952788
53plasma lipoprotein particle remodeling (GO:0034369)4.08952788
54serine family amino acid metabolic process (GO:0009069)4.08401644
55cellular amino acid catabolic process (GO:0009063)4.03770109
56glutamate metabolic process (GO:0006536)4.02820946
57plasma lipoprotein particle clearance (GO:0034381)4.01848818
58proline metabolic process (GO:0006560)3.94584244
59heterochromatin organization (GO:0070828)3.92517696
60phospholipid efflux (GO:0033700)3.92315258
61ethanol oxidation (GO:0006069)3.90960556
62drug catabolic process (GO:0042737)3.90403817
63short-chain fatty acid metabolic process (GO:0046459)3.87211731
64cellular glucuronidation (GO:0052695)3.82996473
65serine family amino acid biosynthetic process (GO:0009070)3.81475479
66coenzyme catabolic process (GO:0009109)3.80219204
67desmosome organization (GO:0002934)3.78335988
68bile acid and bile salt transport (GO:0015721)3.76618368
69aspartate family amino acid catabolic process (GO:0009068)3.76172715
70ketone body metabolic process (GO:1902224)3.75994635
71benzene-containing compound metabolic process (GO:0042537)3.74691244
72acetyl-CoA metabolic process (GO:0006084)3.73105969
73indolalkylamine metabolic process (GO:0006586)3.71228972
74drug transmembrane transport (GO:0006855)3.71111518
75planar cell polarity pathway involved in neural tube closure (GO:0090179)3.67469824
762-oxoglutarate metabolic process (GO:0006103)3.66697402
77fatty acid beta-oxidation (GO:0006635)3.64389108
78dicarboxylic acid biosynthetic process (GO:0043650)3.63603431
79imidazole-containing compound metabolic process (GO:0052803)3.61765069
80establishment of apical/basal cell polarity (GO:0035089)3.60166610
81carboxylic acid catabolic process (GO:0046395)3.59131376
82organic acid catabolic process (GO:0016054)3.59131376
83cellular biogenic amine catabolic process (GO:0042402)3.58829410
84amine catabolic process (GO:0009310)3.58829410
85arginine metabolic process (GO:0006525)3.58717436
86urate metabolic process (GO:0046415)3.58542717
87positive regulation of fatty acid beta-oxidation (GO:0032000)3.58064112
88fibrinolysis (GO:0042730)3.57286069
89fatty acid oxidation (GO:0019395)3.56455337
90cholesterol efflux (GO:0033344)3.52458939
91positive regulation of lipoprotein lipase activity (GO:0051006)3.52154108
92positive regulation of triglyceride lipase activity (GO:0061365)3.52154108
93positive regulation of lipid catabolic process (GO:0050996)3.50342362
94lipid oxidation (GO:0034440)3.49280376
95L-serine metabolic process (GO:0006563)3.48348208
96cholesterol homeostasis (GO:0042632)3.48327986
97plasma lipoprotein particle assembly (GO:0034377)3.46689907
98monocarboxylic acid catabolic process (GO:0072329)3.45332178
99sterol homeostasis (GO:0055092)3.45323718
100protein retention in ER lumen (GO:0006621)3.44375337
101aldehyde catabolic process (GO:0046185)3.43333620
102uronic acid metabolic process (GO:0006063)3.42929386
103glucuronate metabolic process (GO:0019585)3.42929386
104lipoprotein metabolic process (GO:0042157)3.42180909
105fatty acid catabolic process (GO:0009062)3.41047964
106phospholipid homeostasis (GO:0055091)3.38924198
107intestinal cholesterol absorption (GO:0030299)3.38826025
108carnitine metabolic process (GO:0009437)3.35618764
109regulation of bile acid biosynthetic process (GO:0070857)3.35131230
110viral transcription (GO:0019083)3.33164642
111NADH metabolic process (GO:0006734)3.26800943
112regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.24096462
113maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.19025504
114translational termination (GO:0006415)3.09367876
115establishment or maintenance of monopolar cell polarity (GO:0061339)3.08651770
116establishment of monopolar cell polarity (GO:0061162)3.08651770
117paraxial mesoderm development (GO:0048339)3.05519204
118epithelial cell-cell adhesion (GO:0090136)3.03423249
119protein complex localization (GO:0031503)2.88699930
120gap junction assembly (GO:0016264)2.88075463
121Golgi transport vesicle coating (GO:0048200)2.86953941
122COPI coating of Golgi vesicle (GO:0048205)2.86953941
123protein maturation by protein folding (GO:0022417)2.85314348
1244-hydroxyproline metabolic process (GO:0019471)2.84934263
125regulation of mammary gland epithelial cell proliferation (GO:0033599)2.82745497
126regulation of translational fidelity (GO:0006450)2.79974765
127convergent extension (GO:0060026)2.79349865
128maturation of SSU-rRNA (GO:0030490)2.78938533
129translational elongation (GO:0006414)2.73589502
130bundle of His cell to Purkinje myocyte communication (GO:0086069)2.72657138
131GDP-mannose metabolic process (GO:0019673)2.72508247
132regulation of cholesterol biosynthetic process (GO:0045540)2.69328168
133regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.67780723
134ribosomal small subunit assembly (GO:0000028)2.64790293
135maternal placenta development (GO:0001893)2.63434379
136nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.62765530
137SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.60922381
138glutamine family amino acid biosynthetic process (GO:0009084)2.60772305
139peptidyl-arginine omega-N-methylation (GO:0035247)2.58183465
140viral life cycle (GO:0019058)2.57422125
141negative regulation of cell fate specification (GO:0009996)2.54401718
142regulation of mitochondrial translation (GO:0070129)2.54370527
143establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.54081102
144protein targeting to ER (GO:0045047)2.53998745
145cotranslational protein targeting to membrane (GO:0006613)2.53002449
146gluconeogenesis (GO:0006094)2.52772958
147apoptotic process involved in morphogenesis (GO:0060561)2.52387920
148glucose 6-phosphate metabolic process (GO:0051156)2.51350002
149regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.51287556
150cellular protein complex localization (GO:0034629)2.51172907
151histone arginine methylation (GO:0034969)2.50329507
152Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.47567239
153regulation of cardioblast differentiation (GO:0051890)2.46652291
154regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.45856717
155cellular protein complex disassembly (GO:0043624)2.45556843
156cochlea morphogenesis (GO:0090103)2.43984258
157establishment of protein localization to endoplasmic reticulum (GO:0072599)2.43645107
158establishment or maintenance of apical/basal cell polarity (GO:0035088)2.42915870
159establishment or maintenance of bipolar cell polarity (GO:0061245)2.42915870
160monosaccharide biosynthetic process (GO:0046364)2.42055487
161formation of translation preinitiation complex (GO:0001731)2.41841776
162protein localization to endoplasmic reticulum (GO:0070972)2.41575818
163negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.41315085
164cell-cell junction maintenance (GO:0045217)2.40891990
165hexose biosynthetic process (GO:0019319)2.40152793
166adherens junction assembly (GO:0034333)2.39586969
167DNA unwinding involved in DNA replication (GO:0006268)2.39481362
168basement membrane organization (GO:0071711)2.39265435
169branching involved in salivary gland morphogenesis (GO:0060445)2.34980951
170glucose catabolic process (GO:0006007)2.32543205
171notochord development (GO:0030903)2.32391523
172protein complex disassembly (GO:0043241)2.31836792
173diaphragm development (GO:0060539)2.31261277
174regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.30638156
175translational initiation (GO:0006413)2.30149835
176primary alcohol catabolic process (GO:0034310)2.28188146
177retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.27890396
178regulation of establishment of planar polarity (GO:0090175)2.26379218
179midgut development (GO:0007494)2.26188160
180skeletal muscle organ development (GO:0060538)2.25366129
181ribonucleoprotein complex biogenesis (GO:0022613)2.24962609
182tooth mineralization (GO:0034505)2.24517376
183mammary gland epithelial cell differentiation (GO:0060644)2.21572638
184nucleobase-containing small molecule interconversion (GO:0015949)2.21442827
185atrioventricular valve morphogenesis (GO:0003181)2.21262307
186calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.21006067
187embryonic skeletal joint morphogenesis (GO:0060272)2.18951070
188non-canonical Wnt signaling pathway (GO:0035567)2.18810737
189regulation of cholesterol metabolic process (GO:0090181)2.18353648
190lung epithelium development (GO:0060428)2.17170854
191endothelial cell morphogenesis (GO:0001886)2.15857234

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.20704603
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.42462755
3LXR_22158963_ChIP-Seq_LIVER_Mouse5.61251547
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.53371520
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.99518185
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.35657077
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.80058511
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.56651017
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.75406991
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.74413721
11CLOCK_20551151_ChIP-Seq_293T_Human2.58012704
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.53313019
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.45119268
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.43382098
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.40561827
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.17887347
17ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.15394086
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.12406110
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.2696798
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.84427819
21E2F7_22180533_ChIP-Seq_HELA_Human1.82539285
22MYC_19079543_ChIP-ChIP_MESCs_Mouse1.81885590
23MYC_18358816_ChIP-ChIP_MESCs_Mouse1.78995039
24XRN2_22483619_ChIP-Seq_HELA_Human1.76706403
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.69776392
26ZNF263_19887448_ChIP-Seq_K562_Human1.63587812
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.61922651
28KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.59663594
29CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.59103219
30ZFP281_18757296_ChIP-ChIP_E14_Mouse1.57095346
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.56803989
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55306166
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.52554480
34FOXA2_19822575_ChIP-Seq_HepG2_Human1.52074928
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51859445
36SRY_22984422_ChIP-ChIP_TESTIS_Rat1.51523364
37* P68_20966046_ChIP-Seq_HELA_Human1.48413603
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.48039873
39SOX2_27498859_Chip-Seq_STOMACH_Mouse1.46726041
40* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45180632
41* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43710859
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39711689
43CTCF_27219007_Chip-Seq_Bcells_Human1.39274296
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36448276
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.35873606
46VDR_21846776_ChIP-Seq_THP-1_Human1.35853394
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.35083746
48* KDM2B_26808549_Chip-Seq_K562_Human1.34173336
49AR_21909140_ChIP-Seq_LNCAP_Human1.34099488
50* LXR_22292898_ChIP-Seq_THP-1_Human1.32803922
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.30829569
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29735756
53* HNF4A_19822575_ChIP-Seq_HepG2_Human1.29713468
54KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.29422074
55ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29033397
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28297073
57FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26431621
58* SA1_27219007_Chip-Seq_ERYTHROID_Human1.26372958
59CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.25647321
60* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.24740719
61ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23717245
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23268536
63RACK7_27058665_Chip-Seq_MCF-7_Human1.21602228
64E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21009533
65SMC4_20622854_ChIP-Seq_HELA_Human1.20642520
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.20366594
67GATA4_25053715_ChIP-Seq_YYC3_Human1.19663075
68* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18777041
69NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.18394466
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18334281
71CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15927713
72ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15519237
73* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14444071
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14324772
75CDX2_20551321_ChIP-Seq_CACO-2_Human1.13954216
76CTCF_18555785_ChIP-Seq_MESCs_Mouse1.13919265
77KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13771665
78* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.12335406
79TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11503587
80POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10769470
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09059822
82* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08155605
83FOXP1_21924763_ChIP-Seq_HESCs_Human1.08059709
84* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06636070
85* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06007453
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05633771
87CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03964123
88* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.03055730
89* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02244243
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00398600
91CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00096548
92TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.99499919
93MYC_22102868_ChIP-Seq_BL_Human0.99227595
94MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98976750
95FOXO3_23340844_ChIP-Seq_DLD1_Human0.98458013
96GATA6_25053715_ChIP-Seq_YYC3_Human0.96679933
97ATF3_27146783_Chip-Seq_COLON_Human0.95645565
98* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94690906
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93198276
100* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93032350
101RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92064551
102ESR1_20079471_ChIP-ChIP_T-47D_Human0.91521938
103TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89756173
104* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89521870
105ELK3_25401928_ChIP-Seq_HUVEC_Human0.88915289
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88648806
107SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86996701
108GATA1_22025678_ChIP-Seq_K562_Human0.82866907
109SOX2_20726797_ChIP-Seq_SW620_Human0.82559976
110* TBX20_22328084_ChIP-Seq_HEART_Mouse0.81897168
111* TBX20_22080862_ChIP-Seq_HEART_Mouse0.81897168
112FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81146411
113SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.81063145
114ERG_21242973_ChIP-ChIP_JURKAT_Human0.81035017
115HIF1A_21447827_ChIP-Seq_MCF-7_Human0.80714302
116ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.80333866
117RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.78390631
118TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.77712357
119KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.77675454
120CREB1_26743006_Chip-Seq_LNCaP_Human0.76348707
121* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72657982
122SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.72061509
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.71305299
124CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.70973195
125SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70709251
126PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.68581428
127* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.68456817
128P63_26484246_Chip-Seq_KERATINOCYTES_Human0.68193448
129POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.67966560
130RAD21_21589869_ChIP-Seq_MESCs_Mouse0.64988873
131ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.64693122
132TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.64668498
133* RARA_24833708_ChIP-Seq_LIVER_Mouse0.64010517
134* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.62493506
135NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.62165676
136NRF2_20460467_ChIP-Seq_MEFs_Mouse0.62165676
137RUNX1_27514584_Chip-Seq_MCF-7_Human0.62005932
138* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.61791102
139UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.61190367
140GATA3_24758297_ChIP-Seq_MCF-7_Human0.60862369
141GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.60425993
142ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.59961471
143SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.59391740
144SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.59190433
145TCF3_18692474_ChIP-Seq_MEFs_Mouse0.58538929
146TET1_21451524_ChIP-Seq_MESCs_Mouse0.58517989
147BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.56780703
148STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.55967712
149GATA1_19941826_ChIP-Seq_K562_Human0.55619264
150* RARB_24833708_ChIP-Seq_LIVER_Mouse0.55186192
151BCOR_27268052_Chip-Seq_Bcells_Human0.54761841
152EGR1_19032775_ChIP-ChIP_M12_Human0.54248483
153FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.53948622

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.41057352
2MP0005360_urolithiasis7.11213320
3MP0005085_abnormal_gallbladder_physiolo5.60385177
4MP0005365_abnormal_bile_salt5.31172571
5MP0008875_abnormal_xenobiotic_pharmacok4.22510447
6MP0003806_abnormal_nucleotide_metabolis3.77056110
7MP0003252_abnormal_bile_duct3.60062012
8MP0010329_abnormal_lipoprotein_level3.15289020
9MP0010030_abnormal_orbit_morphology3.14725100
10MP0009840_abnormal_foam_cell3.13522002
11MP0009379_abnormal_foot_pigmentation3.10305524
12MP0005083_abnormal_biliary_tract3.03619351
13MP0005332_abnormal_amino_acid2.85029201
14MP0000566_synostosis2.78487698
15MP0001666_abnormal_nutrient_absorption2.71807273
16MP0003705_abnormal_hypodermis_morpholog2.64252436
17MP0003195_calcinosis2.52932053
18MP0004858_abnormal_nervous_system2.43465733
19MP0003123_paternal_imprinting2.35577081
20MP0003191_abnormal_cellular_cholesterol2.34206317
21MP0002249_abnormal_larynx_morphology2.32053387
22MP0004019_abnormal_vitamin_homeostasis2.24455013
23MP0000678_abnormal_parathyroid_gland2.21629499
24MP0002138_abnormal_hepatobiliary_system2.07473862
25MP0003941_abnormal_skin_development1.93535881
26MP0000609_abnormal_liver_physiology1.89034515
27MP0002118_abnormal_lipid_homeostasis1.88208383
28MP0003693_abnormal_embryo_hatching1.75930468
29MP0005319_abnormal_enzyme/_coenzyme1.70912412
30MP0005623_abnormal_meninges_morphology1.69740496
31MP0009643_abnormal_urine_homeostasis1.61343050
32MP0001849_ear_inflammation1.56865117
33MP0004957_abnormal_blastocyst_morpholog1.52210702
34MP0005257_abnormal_intraocular_pressure1.51455151
35MP0000049_abnormal_middle_ear1.50437739
36MP0003942_abnormal_urinary_system1.50225285
37MP0003868_abnormal_feces_composition1.47513862
38MP0010234_abnormal_vibrissa_follicle1.44031478
39MP0005076_abnormal_cell_differentiation1.42067510
40MP0000762_abnormal_tongue_morphology1.39500662
41MP0002098_abnormal_vibrissa_morphology1.39399821
42MP0000003_abnormal_adipose_tissue1.38019383
43MP0001346_abnormal_lacrimal_gland1.35038404
44MP0005584_abnormal_enzyme/coenzyme_acti1.31130981
45MP0008932_abnormal_embryonic_tissue1.27773893
46MP0000462_abnormal_digestive_system1.26892367
47MP0002697_abnormal_eye_size1.25449437
48MP0005451_abnormal_body_composition1.23538281
49MP0001730_embryonic_growth_arrest1.22721035
50MP0010368_abnormal_lymphatic_system1.22544338
51MP0000751_myopathy1.15395579
52MP0008438_abnormal_cutaneous_collagen1.13840858
53MP0000579_abnormal_nail_morphology1.13747722
54MP0009053_abnormal_anal_canal1.13544646
55MP0002254_reproductive_system_inflammat1.13255281
56MP0004233_abnormal_muscle_weight1.12003459
57MP0002089_abnormal_postnatal_growth/wei1.11968646
58MP0000534_abnormal_ureter_morphology1.10963342
59MP0003186_abnormal_redox_activity1.10859149
60MP0000598_abnormal_liver_morphology1.10695505
61MP0003315_abnormal_perineum_morphology1.10163882
62MP0001764_abnormal_homeostasis1.08951034
63MP0001188_hyperpigmentation1.08839116
64MP0003937_abnormal_limbs/digits/tail_de1.08710709
65MP0003119_abnormal_digestive_system1.08287011
66MP0005409_darkened_coat_color1.07320151
67MP0010352_gastrointestinal_tract_polyps1.06649192
68MP0002085_abnormal_embryonic_tissue1.04644121
69MP0002111_abnormal_tail_morphology1.01521648
70MP0005636_abnormal_mineral_homeostasis0.98765306
71MP0003111_abnormal_nucleus_morphology0.97701113
72MP0009250_abnormal_appendicular_skeleto0.97519834
73MP0001756_abnormal_urination0.96771149
74MP0005084_abnormal_gallbladder_morpholo0.96273889
75MP0002796_impaired_skin_barrier0.94924313
76MP0005220_abnormal_exocrine_pancreas0.93287044
77MP0005377_hearing/vestibular/ear_phenot0.92480932
78MP0003878_abnormal_ear_physiology0.92480932
79MP0003938_abnormal_ear_development0.90923414
80MP0009384_cardiac_valve_regurgitation0.90717893
81MP0005380_embryogenesis_phenotype0.89941916
82MP0001672_abnormal_embryogenesis/_devel0.89941916
83MP0000013_abnormal_adipose_tissue0.86029105
84MP0003755_abnormal_palate_morphology0.85132329
85MP0002837_dystrophic_cardiac_calcinosis0.84721508
86MP0002084_abnormal_developmental_patter0.83568809
87MP0003011_delayed_dark_adaptation0.83310022
88MP0004272_abnormal_basement_membrane0.83213791
89MP0003385_abnormal_body_wall0.82375410
90MP0005670_abnormal_white_adipose0.81721029
91MP0003984_embryonic_growth_retardation0.80972743
92MP0005647_abnormal_sex_gland0.80776234
93MP0009697_abnormal_copulation0.79612853
94MP0002092_abnormal_eye_morphology0.79609330
95MP0000477_abnormal_intestine_morphology0.79550318
96MP0002163_abnormal_gland_morphology0.79451044
97MP0002080_prenatal_lethality0.79145936
98MP0000604_amyloidosis0.79029826
99MP0006292_abnormal_olfactory_placode0.78947300
100MP0005275_abnormal_skin_tensile0.78650819
101MP0002116_abnormal_craniofacial_bone0.78434005
102MP0005666_abnormal_adipose_tissue0.77608897
103MP0002160_abnormal_reproductive_system0.77216221
104MP0010630_abnormal_cardiac_muscle0.76494484
105MP0002136_abnormal_kidney_physiology0.76197007
106MP0009642_abnormal_blood_homeostasis0.76146734
107MP0004043_abnormal_pH_regulation0.76063493
108MP0002088_abnormal_embryonic_growth/wei0.75995796
109MP0000428_abnormal_craniofacial_morphol0.75952891
110MP0002233_abnormal_nose_morphology0.75492823
111MP0004130_abnormal_muscle_cell0.75384853
112MP0001881_abnormal_mammary_gland0.74955159
113MP0009763_increased_sensitivity_to0.74882027
114MP0001664_abnormal_digestion0.74471630
115MP0002877_abnormal_melanocyte_morpholog0.74087950
116MP0006036_abnormal_mitochondrial_physio0.73844684
117MP0003861_abnormal_nervous_system0.73469394
118MP0002971_abnormal_brown_adipose0.72505709
119MP0002060_abnormal_skin_morphology0.71788477
120MP0002932_abnormal_joint_morphology0.71695673
121MP0000377_abnormal_hair_follicle0.71183394
122MP0000733_abnormal_muscle_development0.70996155
123MP0005408_hypopigmentation0.70958021
124MP0003935_abnormal_craniofacial_develop0.70261391
125MP0003300_gastrointestinal_ulcer0.70005056
126MP0002078_abnormal_glucose_homeostasis0.69979285
127MP0009764_decreased_sensitivity_to0.66140718
128MP0003453_abnormal_keratinocyte_physiol0.64887728
129MP0004264_abnormal_extraembryonic_tissu0.63794189
130MP0005023_abnormal_wound_healing0.61811266
131MP0003566_abnormal_cell_adhesion0.61781411
132MP0005376_homeostasis/metabolism_phenot0.61486199
133MP0008469_abnormal_protein_level0.60939068
134MP0005330_cardiomyopathy0.57649921
135MP0003656_abnormal_erythrocyte_physiolo0.57409166
136MP0003283_abnormal_digestive_organ0.56685583
137MP0005058_abnormal_lysosome_morphology0.56106653
138MP0005334_abnormal_fat_pad0.55612356
139MP0004185_abnormal_adipocyte_glucose0.55539668
140MP0001765_abnormal_ion_homeostasis0.55411309
141MP0002295_abnormal_pulmonary_circulatio0.54254615
142MP0001243_abnormal_dermal_layer0.53162598
143MP0005266_abnormal_metabolism0.52324519
144MP0000537_abnormal_urethra_morphology0.51348059
145MP0002168_other_aberrant_phenotype0.50807988
146MP0009765_abnormal_xenobiotic_induced0.49262305
147MP0003329_amyloid_beta_deposits0.48494483
148MP0005501_abnormal_skin_physiology0.48270581
149MP0002928_abnormal_bile_duct0.47627627
150MP0002135_abnormal_kidney_morphology0.46791162
151MP0002896_abnormal_bone_mineralization0.46336103
152MP0000538_abnormal_urinary_bladder0.46108021
153MP0003638_abnormal_response/metabolism_0.45728078
154MP0005395_other_phenotype0.44970804
155MP0002269_muscular_atrophy0.44911623
156MP0006138_congestive_heart_failure0.44262781
157MP0005448_abnormal_energy_balance0.44220979
158MP0005535_abnormal_body_temperature0.43516407
159MP0005375_adipose_tissue_phenotype0.43376621
160MP0009672_abnormal_birth_weight0.43069229
161MP0001661_extended_life_span0.42622616
162MP0006035_abnormal_mitochondrial_morpho0.39772514
163MP0004782_abnormal_surfactant_physiolog0.39661823
164MP0005248_abnormal_Harderian_gland0.39658655
165MP0005167_abnormal_blood-brain_barrier0.39205721
166MP0000230_abnormal_systemic_arterial0.38827505
167MP0000467_abnormal_esophagus_morphology0.38273470
168MP0001958_emphysema0.37858845

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.43495127
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.37727299
3Intrahepatic cholestasis (HP:0001406)6.20987787
4Xanthomatosis (HP:0000991)5.76081973
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.73554020
6Hypobetalipoproteinemia (HP:0003563)5.25182412
7Prolonged partial thromboplastin time (HP:0003645)4.88893857
8Hyperlipoproteinemia (HP:0010980)4.57082940
9Abnormality of glutamine family amino acid metabolism (HP:0010902)4.41896161
10Hyperammonemia (HP:0001987)4.37495919
11Complement deficiency (HP:0004431)4.33618372
12Ketosis (HP:0001946)4.28586451
13Hyperglycinuria (HP:0003108)4.20103389
14Hypolipoproteinemia (HP:0010981)4.07838034
15Hyperglycinemia (HP:0002154)4.06367765
16Abnormality of glycine metabolism (HP:0010895)3.98963700
17Abnormality of serine family amino acid metabolism (HP:0010894)3.98963700
18Hypoglycemic coma (HP:0001325)3.80349919
19Abnormality of sulfur amino acid metabolism (HP:0004339)3.78907278
20Epidermoid cyst (HP:0200040)3.74437905
21Abnormality of the common coagulation pathway (HP:0010990)3.73828291
22Hypoalphalipoproteinemia (HP:0003233)3.69160815
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.69154757
24Joint hemorrhage (HP:0005261)3.66539102
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.61174316
26Fat malabsorption (HP:0002630)3.55872815
27Ketoacidosis (HP:0001993)3.52335613
28Abnormality of fatty-acid metabolism (HP:0004359)3.50976603
29Gout (HP:0001997)3.33756776
30Abnormality of complement system (HP:0005339)3.27658808
31Abnormality of the intrinsic pathway (HP:0010989)3.26363859
32Abnormality of methionine metabolism (HP:0010901)3.21433658
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.09116878
34Abnormality of purine metabolism (HP:0004352)3.01798642
35Abnormality of nucleobase metabolism (HP:0010932)2.99000136
36Hypercholesterolemia (HP:0003124)2.95329272
37Hepatocellular carcinoma (HP:0001402)2.94051247
38Abnormality of pyrimidine metabolism (HP:0004353)2.93403123
39Delayed CNS myelination (HP:0002188)2.89622937
40Ulnar bowing (HP:0003031)2.83761541
41Stridor (HP:0010307)2.78399981
42Partial duplication of thumb phalanx (HP:0009944)2.78230632
43Malnutrition (HP:0004395)2.77360968
44Dicarboxylic aciduria (HP:0003215)2.76728146
45Abnormality of dicarboxylic acid metabolism (HP:0010995)2.76728146
46Premature rupture of membranes (HP:0001788)2.76246130
47Conjugated hyperbilirubinemia (HP:0002908)2.72796397
48Vascular calcification (HP:0004934)2.72078042
49Aplasia/Hypoplasia of the sacrum (HP:0008517)2.71963777
50Hyperbilirubinemia (HP:0002904)2.71667305
51Partial duplication of the phalanx of hand (HP:0009999)2.67764398
52Skin nodule (HP:0200036)2.67162056
53Myocardial infarction (HP:0001658)2.65709722
54Metabolic acidosis (HP:0001942)2.63791572
55Spastic diplegia (HP:0001264)2.63156748
56Abnormality of the distal phalanges of the toes (HP:0010182)2.58814351
57Cardiovascular calcification (HP:0011915)2.57257019
58Achilles tendon contracture (HP:0001771)2.55669512
59Abnormality of serum amino acid levels (HP:0003112)2.55194370
60Steatorrhea (HP:0002570)2.53898750
61Abnormality of proline metabolism (HP:0010907)2.46291954
62Hydroxyprolinuria (HP:0003080)2.46291954
63Esophageal varix (HP:0002040)2.45475536
64Late onset (HP:0003584)2.45382585
65Lethargy (HP:0001254)2.44277554
66Myopathic facies (HP:0002058)2.43200525
67Neonatal onset (HP:0003623)2.41961660
68Hyperacusis (HP:0010780)2.35119401
69Hyperuricemia (HP:0002149)2.34206498
70Increased purine levels (HP:0004368)2.34206498
71Abnormal cartilage morphology (HP:0002763)2.30896821
72Trismus (HP:0000211)2.29328324
73Generalized aminoaciduria (HP:0002909)2.27686245
74Spontaneous abortion (HP:0005268)2.26932063
75Distal lower limb muscle weakness (HP:0009053)2.25238443
76Reticulocytopenia (HP:0001896)2.25070045
77Distal upper limb amyotrophy (HP:0007149)2.22454725
78Upper limb amyotrophy (HP:0009129)2.22454725
79Shallow orbits (HP:0000586)2.21593822
80Proximal tubulopathy (HP:0000114)2.21135891
81Broad distal phalanx of finger (HP:0009836)2.20466778
82Mildly elevated creatine phosphokinase (HP:0008180)2.18087995
83Systemic lupus erythematosus (HP:0002725)2.17461014
84Flat acetabular roof (HP:0003180)2.17410415
85Right ventricular cardiomyopathy (HP:0011663)2.15976713
86Cholelithiasis (HP:0001081)2.15388563
87Cerebral edema (HP:0002181)2.15099869
88Abnormal gallbladder morphology (HP:0012437)2.13691758
89Vomiting (HP:0002013)2.13328394
90Abnormality of the aortic arch (HP:0012303)2.10702528
91Abnormality of the umbilical cord (HP:0010881)2.10539120
92Hypoglycemic seizures (HP:0002173)2.09515261
93Sensorimotor neuropathy (HP:0007141)2.09170339
94Abnormality of the Achilles tendon (HP:0005109)2.08470492
95Mitral stenosis (HP:0001718)2.06461998
96Irritability (HP:0000737)2.06248438
97Alkalosis (HP:0001948)2.03732205
98Enlarged kidneys (HP:0000105)2.03531796
99Back pain (HP:0003418)2.02346823
100Pancreatitis (HP:0001733)2.01082489
101Selective tooth agenesis (HP:0001592)2.00451084
102Distal lower limb amyotrophy (HP:0008944)1.99565730
103Protrusio acetabuli (HP:0003179)1.98309972
104Pterygium (HP:0001059)1.98123543
105Abnormality of the phalanges of the hallux (HP:0010057)1.96802507
106Truncus arteriosus (HP:0001660)1.95744736
107Rickets (HP:0002748)1.94915119
108Septate vagina (HP:0001153)1.94863772
109Microretrognathia (HP:0000308)1.94648453
110Turricephaly (HP:0000262)1.94449858
111Pili torti (HP:0003777)1.94313203
112Hyperthyroidism (HP:0000836)1.92746090
113Cholecystitis (HP:0001082)1.91966912
114Abnormal gallbladder physiology (HP:0012438)1.91966912
115Abnormality of cells of the erythroid lineage (HP:0012130)1.91685655
116Abnormal enzyme/coenzyme activity (HP:0012379)1.91138640
117Glycosuria (HP:0003076)1.91028746
118Abnormality of urine glucose concentration (HP:0011016)1.91028746
119Abnormality of the distal phalanx of the thumb (HP:0009617)1.90553490
120Lymphangioma (HP:0100764)1.90274719
121Nephrolithiasis (HP:0000787)1.90128872
122Hemorrhage of the eye (HP:0011885)1.89046627
123Menorrhagia (HP:0000132)1.88692156
124Duplication of thumb phalanx (HP:0009942)1.86364487
125Fragile skin (HP:0001030)1.84948431
126Glomerulonephritis (HP:0000099)1.84488530
127Myoglobinuria (HP:0002913)1.84446987
128Transposition of the great arteries (HP:0001669)1.83461629
129Abnormal connection of the cardiac segments (HP:0011545)1.83461629
130Abnormal ventriculo-arterial connection (HP:0011563)1.83461629
131Short nail (HP:0001799)1.83006960
132Increased connective tissue (HP:0009025)1.81894685
133Hyperinsulinemic hypoglycemia (HP:0000825)1.81165240
134Peritonitis (HP:0002586)1.80379042
135Spinal cord compression (HP:0002176)1.80337477
136Amyloidosis (HP:0011034)1.79983473
137Coronal craniosynostosis (HP:0004440)1.79569200
138Long palpebral fissure (HP:0000637)1.79479637
139Brushfield spots (HP:0001088)1.79341205
140Abnormality of the gallbladder (HP:0005264)1.78164294
141Bowing of the arm (HP:0006488)1.77652216
142Bowed forearm bones (HP:0003956)1.77652216
143Macrocytic anemia (HP:0001972)1.77469972
144Vaginal fistula (HP:0004320)1.76732428
145Acanthocytosis (HP:0001927)1.76360648
146Disproportionate tall stature (HP:0001519)1.76349288
147Premature skin wrinkling (HP:0100678)1.74771538
148Progressive muscle weakness (HP:0003323)1.74124907
149Opisthotonus (HP:0002179)1.73725886
150Abnormality of carpal bone ossification (HP:0006257)1.73686068
151Testicular atrophy (HP:0000029)1.73097715
152Bronchomalacia (HP:0002780)1.70153212
153Abnormality of the fetal cardiovascular system (HP:0010948)1.68292798
154Abnormal umbilical cord blood vessels (HP:0011403)1.68292798
155Single umbilical artery (HP:0001195)1.68292798
156Spinal rigidity (HP:0003306)1.67338848
157Abnormality of glycolysis (HP:0004366)1.66807853
158Acanthosis nigricans (HP:0000956)1.66537721
159Choanal stenosis (HP:0000452)1.66103622
160Double outlet right ventricle (HP:0001719)1.65378427
161Congenital malformation of the right heart (HP:0011723)1.65378427
162Atelectasis (HP:0100750)1.63490440
163Abdominal distention (HP:0003270)1.63445769
164Congenital glaucoma (HP:0001087)1.62913751
165Hyperparathyroidism (HP:0000843)1.62230826
166Abnormalities of placenta or umbilical cord (HP:0001194)1.61245595
167Rectal prolapse (HP:0002035)1.60906141
168Breast hypoplasia (HP:0003187)1.60323836
169Vertebral compression fractures (HP:0002953)1.60257210
170Abnormal hair laboratory examination (HP:0003328)1.60048851
171Abnormal number of erythroid precursors (HP:0012131)1.59811787
172Hand muscle atrophy (HP:0009130)1.57307766
173Ankle contracture (HP:0006466)1.56491563
174Bifid scrotum (HP:0000048)1.55735762
175Hypercalcemia (HP:0003072)1.55428077
176Broad metatarsal (HP:0001783)1.55206682
177Nasolacrimal duct obstruction (HP:0000579)1.54168208
178Focal segmental glomerulosclerosis (HP:0000097)1.53679424
179Facial cleft (HP:0002006)1.53577877
180Bulbar palsy (HP:0001283)1.53506684
181Glomerulosclerosis (HP:0000096)1.53142728
182Thin bony cortex (HP:0002753)1.51508435
183Aplasia involving bones of the extremities (HP:0009825)1.51439581
184Aplasia involving bones of the upper limbs (HP:0009823)1.51439581
185Aplasia of the phalanges of the hand (HP:0009802)1.51439581
186Advanced eruption of teeth (HP:0006288)1.51098721

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.40530710
2ERN14.29839668
3TRIB34.29255220
4PKN23.81339107
5SIK13.47795355
6SMG13.46103892
7FGFR43.40100486
8NME22.85844656
9IRAK32.41690702
10PTK62.41169956
11MST1R2.20726365
12LATS12.04596024
13MAP3K101.91486095
14RIPK11.79504548
15TTN1.72878695
16FLT31.69835195
17ERBB41.64200802
18EPHA21.59026212
19VRK21.55987830
20WNK41.54299876
21STK38L1.51757514
22ARAF1.51359219
23BRAF1.48163143
24PDGFRA1.47990039
25PTK21.46720980
26MET1.42492208
27EPHB11.42396275
28BUB11.40898618
29EPHB21.36962249
30RPS6KB21.36907260
31TESK11.35659660
32MAP2K21.31920432
33NME11.29594864
34MUSK1.25869233
35MAP3K31.18407253
36PIK3CG1.18071990
37FER1.17303449
38MAPK111.16773360
39NTRK11.14379185
40TTK1.14291439
41LATS21.13591171
42LRRK21.10094891
43FRK1.07988283
44TAOK31.06283805
45BMX1.05257577
46PBK1.03266066
47NEK91.02910305
48MYLK1.02532039
49MAP3K71.01524212
50KDR1.00783688
51INSRR0.97954424
52TGFBR20.97315525
53DMPK0.95780677
54ABL20.95603084
55DDR20.95529168
56PRKD30.94560291
57MAPK150.93737433
58CDK70.92838800
59LMTK20.90886073
60PAK40.90111295
61TIE10.90062715
62PRKCI0.89766234
63CDK120.89149546
64MAP3K90.84769949
65MAP2K30.84443183
66MAP2K10.84357951
67ERBB20.84306988
68PAK30.84038788
69AURKA0.83741118
70EPHA30.82766585
71ICK0.82026140
72MTOR0.81458105
73EEF2K0.81220539
74DYRK1B0.80930347
75WNK30.80859316
76STK160.80335833
77GSK3A0.79338195
78CDC70.77975849
79MAP2K40.77776778
80FGFR20.75541570
81MAP3K110.75540063
82LIMK10.74481964
83TYK20.74201169
84CDK60.74177615
85PAK20.72524512
86RPS6KA20.70774152
87PRKAA20.70249837
88GRK60.69702354
89KSR20.68856931
90CDK80.68670592
91BRSK10.68069785
92AURKB0.66972769
93PDK40.66401328
94PDK30.66401328
95CHEK20.65126956
96TBK10.64609799
97NEK10.63593151
98JAK20.62920328
99MAP3K20.62031039
100RET0.60449113
101IRAK20.58405556
102STK40.55815658
103MARK20.55754798
104SCYL20.55510963
105DAPK20.54865483
106FGFR10.54421609
107TAOK20.54154906
108DAPK30.52415029
109PRKD20.51632575
110ILK0.50877538
111PIM20.50338710
112PRKCZ0.49704243
113PRKG20.47690422
114PDPK10.47255496
115NEK20.46801434
116PLK10.46108530
117PHKG20.45739219
118PHKG10.45739219
119PRKD10.45432737
120MAP3K10.44946155
121PRPF4B0.44587269
122PRKAA10.43489194
123JAK10.42048750
124DYRK30.41682185
125MAPKAPK30.41536385
126PAK10.41515749
127RPS6KC10.41339617
128RPS6KL10.41339617
129PRKACG0.40685108
130CDK40.39985365
131MAP3K80.38667218
132CAMK2G0.37802663
133CHEK10.37539908
134CDK11A0.37505400
135DYRK20.37035066
136CAMK1D0.36569396
137TYRO30.36157135
138TESK20.36060934
139MAP2K60.35643163
140AKT20.34603179
141TGFBR10.34465214
142PDK20.33525251
143CSNK1E0.33388939
144STK30.32497630
145ROCK10.31956686
146CDK150.31467771
147OXSR10.31066630
148STK380.30142387
149CSK0.30110011
150PIK3CA0.30088501
151CAMK2D0.29941485
152PINK10.29845142

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.94717877
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.34957653
3Nitrogen metabolism_Homo sapiens_hsa009103.30039398
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.28552820
5Arginine biosynthesis_Homo sapiens_hsa002202.92852725
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.81003856
7Fatty acid degradation_Homo sapiens_hsa000712.72562943
8Tryptophan metabolism_Homo sapiens_hsa003802.66499342
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.61664515
10Ribosome_Homo sapiens_hsa030102.55012434
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.42268755
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.39496714
13Complement and coagulation cascades_Homo sapiens_hsa046102.32294491
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24991763
15Butanoate metabolism_Homo sapiens_hsa006502.24184997
16Propanoate metabolism_Homo sapiens_hsa006402.17378451
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.05583731
18Peroxisome_Homo sapiens_hsa041462.02235864
19Fatty acid metabolism_Homo sapiens_hsa012121.93564753
20PPAR signaling pathway_Homo sapiens_hsa033201.93246095
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.88715772
22Histidine metabolism_Homo sapiens_hsa003401.81261621
23Chemical carcinogenesis_Homo sapiens_hsa052041.72212695
24beta-Alanine metabolism_Homo sapiens_hsa004101.71797784
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.68532425
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68522127
27Selenocompound metabolism_Homo sapiens_hsa004501.62586972
28Bile secretion_Homo sapiens_hsa049761.62055763
29Sulfur metabolism_Homo sapiens_hsa009201.62049988
30Pyruvate metabolism_Homo sapiens_hsa006201.58137126
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.55249045
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.54391961
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.54303947
34Phenylalanine metabolism_Homo sapiens_hsa003601.50231618
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.47603055
36Fat digestion and absorption_Homo sapiens_hsa049751.42587157
37Carbon metabolism_Homo sapiens_hsa012001.41617680
38Retinol metabolism_Homo sapiens_hsa008301.41484073
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.35247533
40DNA replication_Homo sapiens_hsa030301.33247123
41Biosynthesis of amino acids_Homo sapiens_hsa012301.32316041
42Starch and sucrose metabolism_Homo sapiens_hsa005001.31904499
43Caffeine metabolism_Homo sapiens_hsa002321.28417456
44Tyrosine metabolism_Homo sapiens_hsa003501.28314443
45Staphylococcus aureus infection_Homo sapiens_hsa051501.27519840
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26959454
47Folate biosynthesis_Homo sapiens_hsa007901.22292196
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21746110
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20831984
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.19668612
51Base excision repair_Homo sapiens_hsa034101.18410436
52Fatty acid elongation_Homo sapiens_hsa000621.17254816
53Maturity onset diabetes of the young_Homo sapiens_hsa049501.16529753
54Basal cell carcinoma_Homo sapiens_hsa052171.15830865
55Arginine and proline metabolism_Homo sapiens_hsa003301.14255156
56Sulfur relay system_Homo sapiens_hsa041221.11676369
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04533991
58Vitamin digestion and absorption_Homo sapiens_hsa049770.97882236
59Notch signaling pathway_Homo sapiens_hsa043300.97312535
60Thyroid cancer_Homo sapiens_hsa052160.96655815
61ABC transporters_Homo sapiens_hsa020100.94433136
62Lysine degradation_Homo sapiens_hsa003100.94091284
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92123930
64Steroid biosynthesis_Homo sapiens_hsa001000.87449202
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87382750
66Hippo signaling pathway_Homo sapiens_hsa043900.85423293
67Huntingtons disease_Homo sapiens_hsa050160.84062839
68Glutathione metabolism_Homo sapiens_hsa004800.83825408
69N-Glycan biosynthesis_Homo sapiens_hsa005100.81759731
70Pyrimidine metabolism_Homo sapiens_hsa002400.79170144
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75879818
72Oxidative phosphorylation_Homo sapiens_hsa001900.75020111
73Glycerolipid metabolism_Homo sapiens_hsa005610.73154046
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71953131
75Parkinsons disease_Homo sapiens_hsa050120.70083244
76One carbon pool by folate_Homo sapiens_hsa006700.66347425
77Spliceosome_Homo sapiens_hsa030400.62092734
78Pentose phosphate pathway_Homo sapiens_hsa000300.61098457
79Hedgehog signaling pathway_Homo sapiens_hsa043400.60077146
80Mismatch repair_Homo sapiens_hsa034300.59889736
81Vibrio cholerae infection_Homo sapiens_hsa051100.58853418
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56644468
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53965116
84Alzheimers disease_Homo sapiens_hsa050100.53621073
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51261599
86Cardiac muscle contraction_Homo sapiens_hsa042600.50680580
87Adherens junction_Homo sapiens_hsa045200.49622351
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48039665
89Fatty acid biosynthesis_Homo sapiens_hsa000610.47887951
90Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.45854118
91RNA polymerase_Homo sapiens_hsa030200.45377804
92Cell cycle_Homo sapiens_hsa041100.43953877
93Metabolic pathways_Homo sapiens_hsa011000.42243338
94Fructose and mannose metabolism_Homo sapiens_hsa000510.42107443
95Wnt signaling pathway_Homo sapiens_hsa043100.41424159
96Galactose metabolism_Homo sapiens_hsa000520.41048732
97RNA transport_Homo sapiens_hsa030130.40946074
98Insulin resistance_Homo sapiens_hsa049310.38002017
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37307919
100Prion diseases_Homo sapiens_hsa050200.36817054
101Vitamin B6 metabolism_Homo sapiens_hsa007500.36345882
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.30783751
103Bladder cancer_Homo sapiens_hsa052190.30142299
104Protein digestion and absorption_Homo sapiens_hsa049740.29191273
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19062234
106Glucagon signaling pathway_Homo sapiens_hsa049220.14692220
107AMPK signaling pathway_Homo sapiens_hsa041520.14239009
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10435219
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.08951484
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.08292657
111Linoleic acid metabolism_Homo sapiens_hsa005910.06707605
112ECM-receptor interaction_Homo sapiens_hsa045120.06308737
113Amoebiasis_Homo sapiens_hsa051460.05513104
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.01710276
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.01594125
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.01383640
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.00767808
118Thyroid hormone synthesis_Homo sapiens_hsa049180.00652431
119Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1336043
120Tight junction_Homo sapiens_hsa04530-0.1334232
121Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1288280
122Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1178447
123Proteoglycans in cancer_Homo sapiens_hsa05205-0.1135343
124Focal adhesion_Homo sapiens_hsa04510-0.0893155
125Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0879369
126Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0342330
127Mineral absorption_Homo sapiens_hsa04978-0.0174365
128Renin-angiotensin system_Homo sapiens_hsa04614-0.0165748
129Insulin signaling pathway_Homo sapiens_hsa04910-0.0039025

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