NR3C1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)4.50707961
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.08493157
3negative regulation of cell killing (GO:0031342)4.08493157
4regulation of gamma-delta T cell activation (GO:0046643)3.53631922
5modulation by symbiont of host defense response (GO:0052031)3.50459261
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.50459261
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.50459261
8positive regulation by organism of defense response of other organism involved in symbiotic interact3.50459261
9modulation by symbiont of host immune response (GO:0052553)3.50459261
10positive regulation by symbiont of host defense response (GO:0052509)3.50459261
11B cell receptor signaling pathway (GO:0050853)3.47298626
12positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.46966282
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.41452012
14negative thymic T cell selection (GO:0045060)3.39616356
15germinal center formation (GO:0002467)3.37861992
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.36420425
17L-phenylalanine catabolic process (GO:0006559)3.36420425
18negative T cell selection (GO:0043383)3.35417884
19detection of molecule of bacterial origin (GO:0032490)3.29435344
20regulation of gamma-delta T cell differentiation (GO:0045586)3.25673133
21response to interleukin-15 (GO:0070672)3.22486639
22response to peptidoglycan (GO:0032494)3.21664739
23negative regulation of interleukin-12 production (GO:0032695)3.21582551
24macrophage activation involved in immune response (GO:0002281)3.16396062
25T cell migration (GO:0072678)3.14358362
26positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.12461602
27negative regulation of T cell mediated immunity (GO:0002710)3.11293378
28cellular response to type I interferon (GO:0071357)3.09113438
29type I interferon signaling pathway (GO:0060337)3.09113438
30response to type I interferon (GO:0034340)3.08458979
31positive thymic T cell selection (GO:0045059)3.06677669
32regulation of interferon-beta biosynthetic process (GO:0045357)3.04609431
33cellular extravasation (GO:0045123)3.03614717
34mature B cell differentiation (GO:0002335)3.02701010
35erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.00831553
36L-phenylalanine metabolic process (GO:0006558)3.00831553
37interferon-gamma-mediated signaling pathway (GO:0060333)3.00548935
38response to muramyl dipeptide (GO:0032495)2.97888179
39alpha-linolenic acid metabolic process (GO:0036109)2.95710536
40detection of other organism (GO:0098543)2.91395530
41positive regulation of B cell differentiation (GO:0045579)2.89955610
42regulation of alpha-beta T cell proliferation (GO:0046640)2.86972872
43cellular response to interleukin-15 (GO:0071350)2.85721760
44CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.85579154
45regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.83640230
46detection of external biotic stimulus (GO:0098581)2.83100054
47triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.82878783
48positive regulation of interferon-alpha production (GO:0032727)2.82857165
49response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.82491094
50response to host (GO:0075136)2.82491094
51response to host defenses (GO:0052200)2.82491094
52growth hormone receptor signaling pathway (GO:0060396)2.82237671
53regulation of necroptotic process (GO:0060544)2.81549575
54positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.80661077
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.79892948
56mature B cell differentiation involved in immune response (GO:0002313)2.78472387
57response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.78196283
58response to host immune response (GO:0052572)2.78196283
59immunoglobulin mediated immune response (GO:0016064)2.76397058
60positive T cell selection (GO:0043368)2.75836800
61valine metabolic process (GO:0006573)2.74839371
62regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.74274343
63regulation of dendritic cell antigen processing and presentation (GO:0002604)2.73794890
64B cell homeostasis (GO:0001782)2.73406961
65regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.73307205
66regulation of interferon-alpha production (GO:0032647)2.72500609
67regulation of T-helper 1 cell differentiation (GO:0045625)2.72473481
68lipopolysaccharide-mediated signaling pathway (GO:0031663)2.72144554
69plasma lipoprotein particle clearance (GO:0034381)2.70043783
70aromatic amino acid family catabolic process (GO:0009074)2.69664580
71low-density lipoprotein particle clearance (GO:0034383)2.69597374
72detection of bacterium (GO:0016045)2.68839613
73regulation of B cell differentiation (GO:0045577)2.67903590
74NIK/NF-kappaB signaling (GO:0038061)2.67504048
75membrane raft organization (GO:0031579)2.67092986
76B cell proliferation (GO:0042100)2.66380992
77regulation of triglyceride catabolic process (GO:0010896)2.65956976
78negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.63180439
79negative regulation of erythrocyte differentiation (GO:0045647)2.61786043
80positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.60328554
81regulation of germinal center formation (GO:0002634)2.60316679
82antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.59879367
83antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.59879367
84positive regulation of macrophage cytokine production (GO:0060907)2.59863524
85regulation of macrophage cytokine production (GO:0010935)2.59845697
86thymic T cell selection (GO:0045061)2.59332509
87complement activation, alternative pathway (GO:0006957)2.58725181
88positive regulation of alpha-beta T cell proliferation (GO:0046641)2.57232502
89protein carboxylation (GO:0018214)2.56934816
90peptidyl-glutamic acid carboxylation (GO:0017187)2.56934816
91negative regulation of lymphocyte mediated immunity (GO:0002707)2.56702391
92fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.56582681
93T-helper 1 type immune response (GO:0042088)2.55228647
94negative regulation of T-helper cell differentiation (GO:0045623)2.53975954
95negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.53975954
96T cell selection (GO:0045058)2.53362463
97hepatocyte apoptotic process (GO:0097284)2.52298280
98tolerance induction (GO:0002507)2.51934694
99positive regulation of interleukin-2 production (GO:0032743)2.51752022
100regulation of B cell proliferation (GO:0030888)2.51370919
101JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.49404636
102leukocyte aggregation (GO:0070486)2.48814856
103microglial cell activation (GO:0001774)2.47186927
104detection of biotic stimulus (GO:0009595)2.46051693
105negative regulation of leukocyte mediated immunity (GO:0002704)2.44625502
106phospholipid efflux (GO:0033700)2.44368772
107positive regulation of fatty acid beta-oxidation (GO:0032000)2.43685116
108positive regulation of granulocyte differentiation (GO:0030854)2.43638984
109defense response to protozoan (GO:0042832)2.43629810
110phospholipid homeostasis (GO:0055091)2.42649325
111bile acid biosynthetic process (GO:0006699)2.42134712
112positive regulation of B cell proliferation (GO:0030890)2.41007227
113regulation of T-helper 2 cell differentiation (GO:0045628)2.40692626
114macrophage activation (GO:0042116)2.40658264
115antigen processing and presentation of endogenous antigen (GO:0019883)2.40510473
116antigen processing and presentation via MHC class Ib (GO:0002475)2.40100358
117cellular response to growth hormone stimulus (GO:0071378)2.37703046
118regulation of interleukin-12 biosynthetic process (GO:0045075)2.37307053
119positive regulation of macrophage differentiation (GO:0045651)2.37155916
120regulation of sequestering of triglyceride (GO:0010889)2.35587525
121positive regulation of lipid catabolic process (GO:0050996)2.35480556
122negative regulation of lipase activity (GO:0060192)2.31010357
123fatty acid beta-oxidation (GO:0006635)2.29980692
124creatine metabolic process (GO:0006600)2.29344902
125short-chain fatty acid metabolic process (GO:0046459)2.26448890
126regulation of cholesterol storage (GO:0010885)2.25123072
127positive regulation of p38MAPK cascade (GO:1900745)2.24029965
128protein localization to endosome (GO:0036010)2.23831229
129fatty acid oxidation (GO:0019395)2.22272860
130triglyceride homeostasis (GO:0070328)2.21721351
131acylglycerol homeostasis (GO:0055090)2.21721351
132lipid oxidation (GO:0034440)2.20671087
133response to lipoprotein particle (GO:0055094)2.20411751
134reverse cholesterol transport (GO:0043691)2.19583633
135positive regulation of fatty acid oxidation (GO:0046321)2.18670660
136negative regulation of fibrinolysis (GO:0051918)2.18277074
137negative regulation of lipid storage (GO:0010888)2.17858830
138regulation of protein activation cascade (GO:2000257)2.17564226
139regulation of fibrinolysis (GO:0051917)2.17161996
140high-density lipoprotein particle remodeling (GO:0034375)2.17082788
141transcytosis (GO:0045056)2.15365793
142fatty acid catabolic process (GO:0009062)2.15087770
143regulation of cholesterol esterification (GO:0010872)2.14498798
144bile acid metabolic process (GO:0008206)2.13345980
145indole-containing compound catabolic process (GO:0042436)2.12807911
146indolalkylamine catabolic process (GO:0046218)2.12807911
147tryptophan catabolic process (GO:0006569)2.12807911
148cholesterol efflux (GO:0033344)2.12315874
149regulation of macrophage derived foam cell differentiation (GO:0010743)2.12092799
150fatty acid transmembrane transport (GO:1902001)2.11950334
151protein-lipid complex remodeling (GO:0034368)2.10372218
152macromolecular complex remodeling (GO:0034367)2.10372218
153plasma lipoprotein particle remodeling (GO:0034369)2.10372218
154regulation of complement activation (GO:0030449)2.09688251
155regulation of cholesterol homeostasis (GO:2000188)2.09396758
156regulation of membrane protein ectodomain proteolysis (GO:0051043)2.07997210
157fatty-acyl-CoA biosynthetic process (GO:0046949)2.07796280
158triglyceride catabolic process (GO:0019433)2.07005150
159regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.06125708
160regulation of lipoprotein metabolic process (GO:0050746)2.04830959
161urea metabolic process (GO:0019627)2.04580201
162urea cycle (GO:0000050)2.04580201
163dicarboxylic acid biosynthetic process (GO:0043650)2.04397566
164kynurenine metabolic process (GO:0070189)2.04169168
165very long-chain fatty acid metabolic process (GO:0000038)2.04049772
166acylglycerol catabolic process (GO:0046464)2.03820947
167neutral lipid catabolic process (GO:0046461)2.03820947
168positive regulation of gamma-delta T cell activation (GO:0046645)2.03776311
169tryptophan metabolic process (GO:0006568)2.03202845
170low-density lipoprotein particle remodeling (GO:0034374)2.02384861
171fatty-acyl-CoA metabolic process (GO:0035337)2.01593224
172cellular response to ethanol (GO:0071361)2.01284917
173long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)1.99882755
174protein-lipid complex assembly (GO:0065005)1.99456321
175regulation of triglyceride metabolic process (GO:0090207)1.99064339
176regulation of cholesterol metabolic process (GO:0090181)1.98967172
177positive regulation of membrane protein ectodomain proteolysis (GO:0051044)1.98542652
178drug transmembrane transport (GO:0006855)1.98440566
179sulfur amino acid catabolic process (GO:0000098)1.97219913
180monocarboxylic acid catabolic process (GO:0072329)1.96998014
181positive regulation of cholesterol transport (GO:0032376)1.96498787
182positive regulation of sterol transport (GO:0032373)1.96498787
183plasma lipoprotein particle assembly (GO:0034377)1.95726086
184negative regulation of protein autophosphorylation (GO:0031953)1.93987553
185cellular glucuronidation (GO:0052695)1.93694598
186cholesterol homeostasis (GO:0042632)1.92500419
187sterol homeostasis (GO:0055092)1.92380646
188thioester biosynthetic process (GO:0035384)1.92367028
189acyl-CoA biosynthetic process (GO:0071616)1.92367028
190cysteine metabolic process (GO:0006534)1.91670038
191positive regulation of coagulation (GO:0050820)1.91136541
192regulation of cholesterol biosynthetic process (GO:0045540)1.90527756
193homocysteine metabolic process (GO:0050667)1.90060213

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.60476639
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.17466928
3EGR1_19374776_ChIP-ChIP_THP-1_Human2.98920140
4RXR_22158963_ChIP-Seq_LIVER_Mouse2.79289179
5* LXR_22158963_ChIP-Seq_LIVER_Mouse2.68792517
6GATA1_22025678_ChIP-Seq_K562_Human2.54709107
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.50151156
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.49990705
9* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.31817290
10MYB_26560356_Chip-Seq_TH2_Human2.28505974
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.28038570
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.24195081
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.07231789
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.02449674
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.92458077
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.92211115
17MYB_26560356_Chip-Seq_TH1_Human1.91481252
18BP1_19119308_ChIP-ChIP_Hs578T_Human1.88714272
19BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87142116
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.80688035
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.77236106
22* RUNX_20019798_ChIP-Seq_JUKART_Human1.75485846
23MAF_26560356_Chip-Seq_TH1_Human1.74823116
24* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.73344902
25* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.68689766
26TRIM28_21343339_ChIP-Seq_HEK293_Human1.67089775
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66379742
28* SPI1_23547873_ChIP-Seq_NB4_Human1.66229868
29MYC_22102868_ChIP-Seq_BL_Human1.65931763
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64957182
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.63627219
32VDR_24763502_ChIP-Seq_THP-1_Human1.61845798
33SPI1_23127762_ChIP-Seq_K562_Human1.58041036
34NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.56589125
35NRF2_20460467_ChIP-Seq_MEFs_Mouse1.56589125
36* IRF8_27001747_Chip-Seq_BMDM_Mouse1.56329030
37* GATA2_21666600_ChIP-Seq_HMVEC_Human1.54811489
38* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.49068303
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.48253833
40* PU_27001747_Chip-Seq_BMDM_Mouse1.47178714
41* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.44471657
42CLOCK_20551151_ChIP-Seq_293T_Human1.43965370
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42863969
44* GATA3_27048872_Chip-Seq_THYMUS_Human1.41467410
45BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.40002666
46TP63_17297297_ChIP-ChIP_HaCaT_Human1.39428080
47SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.38798940
48SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.38798940
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38133424
50* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37926976
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35806099
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35130912
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34574689
54FOXO3_23340844_ChIP-Seq_DLD1_Human1.33770313
55* TCF7_22412390_ChIP-Seq_EML_Mouse1.29452416
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29341409
57IRF8_21731497_ChIP-ChIP_J774_Mouse1.27798521
58* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.27259201
59* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26789670
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.24921410
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.24134986
62TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22650971
63FOXA2_19822575_ChIP-Seq_HepG2_Human1.21981261
64* BRD4_25478319_ChIP-Seq_HGPS_Human1.21836842
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21764698
66* GATA3_26560356_Chip-Seq_TH2_Human1.21519555
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21380203
68AR_21572438_ChIP-Seq_LNCaP_Human1.20962295
69TP53_16413492_ChIP-PET_HCT116_Human1.19590117
70GATA1_19941826_ChIP-Seq_K562_Human1.19450940
71GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18903283
72UTX_26944678_Chip-Seq_JUKART_Human1.18541208
73* VDR_24787735_ChIP-Seq_THP-1_Human1.17471379
74SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15519345
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14772028
76VDR_21846776_ChIP-Seq_THP-1_Human1.11197588
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10494993
78* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10125851
79SCL_19346495_ChIP-Seq_HPC-7_Human1.09677959
80BCAT_22108803_ChIP-Seq_LS180_Human1.08845297
81SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.08750586
82RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.08286886
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08229060
84EP300_21415370_ChIP-Seq_HL-1_Mouse1.07943286
85* SOX2_20726797_ChIP-Seq_SW620_Human1.07462061
86* CJUN_26792858_Chip-Seq_BT549_Human1.07349301
87GATA2_19941826_ChIP-Seq_K562_Human1.06602119
88* PIAS1_25552417_ChIP-Seq_VCAP_Human1.06524470
89JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05898118
90JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05837423
91* TP53_18474530_ChIP-ChIP_U2OS_Human1.05060307
92ESR1_21235772_ChIP-Seq_MCF-7_Human1.04833188
93RXR_22108803_ChIP-Seq_LS180_Human1.04824741
94GATA1_19941827_ChIP-Seq_MEL_Mouse1.04472133
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03128568
96* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02832489
97PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02788068
98* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02473482
99SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02229627
100FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02009383
101GBX2_23144817_ChIP-Seq_PC3_Human1.01234881
102WT1_19549856_ChIP-ChIP_CCG9911_Human1.00707438
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00353447
104IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00289521
105SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00010730
106MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98576215
107* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98454175
108LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98374086
109PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97947406
110TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96098218
111TFEB_21752829_ChIP-Seq_HELA_Human0.95911198
112FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95638856
113* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95312802
114MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95169274
115KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93474988
116* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93419488
117SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93348576
118LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93139976
119MAF_26560356_Chip-Seq_TH2_Human0.93080122
120* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92893056
121SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91853416
122MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.91399494
123SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90806898
124* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90729482
125* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90284485
126RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88444347
127SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.88070811
128* TP63_23658742_ChIP-Seq_EP156T_Human0.87611230
129PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.87406494
130PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87375454
131* AHR_22903824_ChIP-Seq_MCF-7_Human0.87146279
132SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86588148
133AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85911538
134ESR1_20079471_ChIP-ChIP_T-47D_Human0.85595338
135CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85223267
136SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.85186264
137* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.84863930
138* TBX20_22080862_ChIP-Seq_HEART_Mouse0.84183557
139* TBX20_22328084_ChIP-Seq_HEART_Mouse0.84183557
140* ARNT_22903824_ChIP-Seq_MCF-7_Human0.83776139
141KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82282586
142* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82275840
143NR3C1_23031785_ChIP-Seq_PC12_Mouse0.82205933
144ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81849409
145KDM2B_26808549_Chip-Seq_DND41_Human0.81259341
146* TAF15_26573619_Chip-Seq_HEK293_Human0.81226970
147NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.81193857
148* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81087485
149SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.80872854
150* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79898422

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.42025597
2MP0002139_abnormal_hepatobiliary_system3.13624416
3MP0003300_gastrointestinal_ulcer2.74294962
4MP0005365_abnormal_bile_salt2.68559223
5MP0005085_abnormal_gallbladder_physiolo2.61141090
6* MP0003763_abnormal_thymus_physiology2.59070691
7MP0003724_increased_susceptibility_to2.44944116
8MP0008875_abnormal_xenobiotic_pharmacok2.26400238
9MP0003252_abnormal_bile_duct2.24884476
10MP0003191_abnormal_cellular_cholesterol2.02628899
11MP0010329_abnormal_lipoprotein_level1.99613241
12MP0008438_abnormal_cutaneous_collagen1.98140869
13MP0003690_abnormal_glial_cell1.93484948
14MP0004130_abnormal_muscle_cell1.86505415
15MP0009840_abnormal_foam_cell1.86269472
16* MP0001819_abnormal_immune_cell1.85785251
17MP0002166_altered_tumor_susceptibility1.83082731
18MP0003091_abnormal_cell_migration1.77821873
19MP0002138_abnormal_hepatobiliary_system1.71750393
20MP0003195_calcinosis1.71539827
21MP0002254_reproductive_system_inflammat1.65510069
22* MP0002398_abnormal_bone_marrow1.62178551
23MP0002405_respiratory_system_inflammati1.59898785
24MP0003303_peritoneal_inflammation1.59439275
25MP0003656_abnormal_erythrocyte_physiolo1.58322492
26MP0001666_abnormal_nutrient_absorption1.58215857
27MP0001835_abnormal_antigen_presentation1.53231386
28MP0005387_immune_system_phenotype1.52703300
29MP0001790_abnormal_immune_system1.52703300
30* MP0000716_abnormal_immune_system1.49719990
31* MP0002118_abnormal_lipid_homeostasis1.49515604
32MP0008057_abnormal_DNA_replication1.47790526
33MP0003075_altered_response_to1.47582878
34MP0000920_abnormal_myelination1.47382520
35MP0000604_amyloidosis1.46875212
36MP0005451_abnormal_body_composition1.46807411
37MP0010234_abnormal_vibrissa_follicle1.46791856
38MP0009333_abnormal_splenocyte_physiolog1.46532069
39MP0000569_abnormal_digit_pigmentation1.42075342
40MP0010352_gastrointestinal_tract_polyps1.41115700
41MP0005670_abnormal_white_adipose1.39294401
42MP0002396_abnormal_hematopoietic_system1.37559580
43MP0001873_stomach_inflammation1.37404655
44MP0005671_abnormal_response_to1.36947892
45MP0005275_abnormal_skin_tensile1.33869597
46MP0005332_abnormal_amino_acid1.33434717
47MP0000689_abnormal_spleen_morphology1.31767998
48MP0001545_abnormal_hematopoietic_system1.31664351
49MP0005397_hematopoietic_system_phenotyp1.31664351
50MP0005058_abnormal_lysosome_morphology1.31628278
51MP0004947_skin_inflammation1.31533263
52MP0009780_abnormal_chondrocyte_physiolo1.28185123
53MP0004185_abnormal_adipocyte_glucose1.27027177
54MP0002009_preneoplasia1.26828781
55MP0002722_abnormal_immune_system1.26514423
56MP0009785_altered_susceptibility_to1.26133360
57MP0002419_abnormal_innate_immunity1.25978521
58MP0004808_abnormal_hematopoietic_stem1.25507816
59* MP0000609_abnormal_liver_physiology1.25256631
60MP0003045_fibrosis1.24835723
61MP0005666_abnormal_adipose_tissue1.23534143
62MP0005083_abnormal_biliary_tract1.22724023
63MP0002332_abnormal_exercise_endurance1.22168076
64MP0003329_amyloid_beta_deposits1.21660627
65MP0003436_decreased_susceptibility_to1.21243226
66MP0006082_CNS_inflammation1.20034753
67* MP0005000_abnormal_immune_tolerance1.19677309
68* MP0002429_abnormal_blood_cell1.19405757
69MP0001533_abnormal_skeleton_physiology1.19039330
70MP0001853_heart_inflammation1.18355622
71* MP0005584_abnormal_enzyme/coenzyme_acti1.17406090
72MP0000685_abnormal_immune_system1.17339375
73MP0002006_tumorigenesis1.16873792
74MP0000858_altered_metastatic_potential1.16456288
75MP0010368_abnormal_lymphatic_system1.15178964
76MP0000703_abnormal_thymus_morphology1.14637573
77MP0002837_dystrophic_cardiac_calcinosis1.12605350
78MP0009278_abnormal_bone_marrow1.12182196
79MP0002971_abnormal_brown_adipose1.11827623
80MP0008260_abnormal_autophagy1.11234459
81MP0001851_eye_inflammation1.10704567
82MP0002933_joint_inflammation1.10552195
83MP0001800_abnormal_humoral_immune1.09914724
84MP0002148_abnormal_hypersensitivity_rea1.08945857
85MP0003566_abnormal_cell_adhesion1.08838244
86MP0005025_abnormal_response_to1.08449370
87MP0001879_abnormal_lymphatic_vessel1.06614670
88MP0005023_abnormal_wound_healing1.06045603
89MP0004381_abnormal_hair_follicle1.05857030
90MP0010678_abnormal_skin_adnexa1.05726090
91MP0005464_abnormal_platelet_physiology1.05548636
92MP0009764_decreased_sensitivity_to1.04900048
93* MP0008469_abnormal_protein_level1.03728674
94* MP0002998_abnormal_bone_remodeling1.03234047
95MP0002060_abnormal_skin_morphology1.03161978
96MP0000343_altered_response_to1.01817986
97MP0001348_abnormal_lacrimal_gland1.01100836
98MP0005310_abnormal_salivary_gland1.00826361
99MP0003448_altered_tumor_morphology1.00584478
100MP0003172_abnormal_lysosome_physiology1.00009195
101MP0003453_abnormal_keratinocyte_physiol0.98647658
102MP0004510_myositis0.98095061
103* MP0002723_abnormal_immune_serum0.97818811
104MP0005535_abnormal_body_temperature0.97612373
105MP0005164_abnormal_response_to0.96265224
106MP0005334_abnormal_fat_pad0.94109458
107MP0000465_gastrointestinal_hemorrhage0.93539913
108MP0002452_abnormal_antigen_presenting0.93326986
109MP0004883_abnormal_blood_vessel0.92613206
110* MP0001845_abnormal_inflammatory_respons0.92486893
111MP0005319_abnormal_enzyme/_coenzyme0.92407091
112MP0006054_spinal_hemorrhage0.92353657
113* MP0005375_adipose_tissue_phenotype0.92106005
114MP0003279_aneurysm0.92094343
115MP0003828_pulmonary_edema0.91362450
116* MP0005167_abnormal_blood-brain_barrier0.90835208
117MP0005166_decreased_susceptibility_to0.90816928
118MP0009384_cardiac_valve_regurgitation0.89038805
119MP0009643_abnormal_urine_homeostasis0.88389217
120MP0003950_abnormal_plasma_membrane0.88328201
121MP0002877_abnormal_melanocyte_morpholog0.88129889
122* MP0010155_abnormal_intestine_physiology0.86941005
123* MP0000249_abnormal_blood_vessel0.86841322
124MP0004036_abnormal_muscle_relaxation0.84630816
125MP0003866_abnormal_defecation0.82491133
126MP0003705_abnormal_hypodermis_morpholog0.82019873
127* MP0009763_increased_sensitivity_to0.81919637
128MP0001661_extended_life_span0.80681255
129MP0001881_abnormal_mammary_gland0.80627886
130MP0003183_abnormal_peptide_metabolism0.79721195
131MP0003868_abnormal_feces_composition0.79518008
132MP0001501_abnormal_sleep_pattern0.78741154
133MP0001958_emphysema0.78055166
134MP0004019_abnormal_vitamin_homeostasis0.78035873
135* MP0002420_abnormal_adaptive_immunity0.77407452
136MP0005165_increased_susceptibility_to0.77217727
137* MP0003795_abnormal_bone_structure0.75645920
138MP0000371_diluted_coat_color0.73988645
139MP0000015_abnormal_ear_pigmentation0.73072189
140MP0008004_abnormal_stomach_pH0.70951745
141MP0005390_skeleton_phenotype0.70935865

Predicted human phenotypes

RankGene SetZ-score
1Xanthomatosis (HP:0000991)3.94125046
2Complement deficiency (HP:0004431)3.64973454
3Intrahepatic cholestasis (HP:0001406)3.63948664
4Deep venous thrombosis (HP:0002625)3.55689022
5Myocardial infarction (HP:0001658)3.43359788
6Hyperlipoproteinemia (HP:0010980)3.28801963
7Abnormality of aromatic amino acid family metabolism (HP:0004338)3.25734089
8Recurrent viral infections (HP:0004429)3.06594046
9Abnormal delayed hypersensitivity skin test (HP:0002963)3.03692891
10Neurofibrillary tangles (HP:0002185)2.96157909
11Mediastinal lymphadenopathy (HP:0100721)2.95259809
12Amyloidosis (HP:0011034)2.93470097
13Spondylolisthesis (HP:0003302)2.89173846
14Autoimmune hemolytic anemia (HP:0001890)2.87341738
15Recurrent fungal infections (HP:0002841)2.84768474
16Abnormality of the common coagulation pathway (HP:0010990)2.84110757
17Axonal loss (HP:0003447)2.81487808
18Prolonged partial thromboplastin time (HP:0003645)2.80680642
19Hypoglycemic coma (HP:0001325)2.79347497
20Hypoalphalipoproteinemia (HP:0003233)2.76588378
21Elevated erythrocyte sedimentation rate (HP:0003565)2.74497490
22Meningitis (HP:0001287)2.74092568
23Recurrent cutaneous fungal infections (HP:0011370)2.73109218
24Chronic mucocutaneous candidiasis (HP:0002728)2.73109218
25Gastrointestinal infarctions (HP:0005244)2.66266842
26Pulmonary embolism (HP:0002204)2.65141945
27Joint hemorrhage (HP:0005261)2.63706647
28Epidermoid cyst (HP:0200040)2.63191730
29Hematochezia (HP:0002573)2.61387828
30Cellulitis (HP:0100658)2.59793878
31Stomatitis (HP:0010280)2.57712893
32Abnormality of complement system (HP:0005339)2.57303525
33Systemic lupus erythematosus (HP:0002725)2.56118005
34Abnormality of macrophages (HP:0004311)2.54880704
35Abnormality of T cells (HP:0002843)2.52615754
36Colitis (HP:0002583)2.50502590
37Agammaglobulinemia (HP:0004432)2.47562298
38Nemaline bodies (HP:0003798)2.46288196
39Ketosis (HP:0001946)2.43290011
40Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.42362302
41Spontaneous hematomas (HP:0007420)2.41236935
42Inflammation of the large intestine (HP:0002037)2.38696139
43Fat malabsorption (HP:0002630)2.38654892
44Recurrent bronchitis (HP:0002837)2.37988501
45Hypercholesterolemia (HP:0003124)2.34427090
46Aortic aneurysm (HP:0004942)2.34304584
47Mitral stenosis (HP:0001718)2.32093150
48Gingival bleeding (HP:0000225)2.32055501
49Muscle fiber inclusion bodies (HP:0100299)2.32020486
50Abnormality of monocarboxylic acid metabolism (HP:0010996)2.31757075
51Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.31588022
52Type 1 muscle fiber predominance (HP:0003803)2.31240754
53Ketoacidosis (HP:0001993)2.31093851
54Orchitis (HP:0100796)2.30331476
55Glomerulonephritis (HP:0000099)2.25324782
56Hypolipoproteinemia (HP:0010981)2.24228267
57Abnormality of T cell physiology (HP:0011840)2.21650787
58Granulocytopenia (HP:0001913)2.21217893
59Cerebral inclusion bodies (HP:0100314)2.20196140
60Eosinophilia (HP:0001880)2.20104931
61Gastrointestinal inflammation (HP:0004386)2.19983769
62Gingivitis (HP:0000230)2.19030847
63Dilatation of the ascending aorta (HP:0005111)2.16073196
64Osteomyelitis (HP:0002754)2.15942101
65Polycythemia (HP:0001901)2.14759203
66IgA deficiency (HP:0002720)2.13909343
67Pancreatitis (HP:0001733)2.13876700
68Recurrent bacterial skin infections (HP:0005406)2.13855991
69Chest pain (HP:0100749)2.13784136
70Viral hepatitis (HP:0006562)2.13725130
71Emphysema (HP:0002097)2.11721370
72Conjugated hyperbilirubinemia (HP:0002908)2.11338012
73Osteolytic defects of the hand bones (HP:0009699)2.10361740
74Osteolytic defects of the phalanges of the hand (HP:0009771)2.10361740
75Hyperammonemia (HP:0001987)2.10259298
76Spinal cord lesions (HP:0100561)2.09008763
77Syringomyelia (HP:0003396)2.09008763
78Skin nodule (HP:0200036)2.08132198
79Protrusio acetabuli (HP:0003179)2.07558144
80Cardiovascular calcification (HP:0011915)2.07429332
81Increased connective tissue (HP:0009025)2.06522645
82Abnormality of glutamine family amino acid metabolism (HP:0010902)2.05460860
83Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.03550543
84Abnormality of glycosphingolipid metabolism (HP:0004343)2.03441528
85Abnormality of glycolipid metabolism (HP:0010969)2.03441528
86Abnormality of liposaccharide metabolism (HP:0010968)2.03441528
87Vascular calcification (HP:0004934)2.02960881
88Hypoglycemic seizures (HP:0002173)2.02558769
89Retrobulbar optic neuritis (HP:0100654)2.00910654
90Optic neuritis (HP:0100653)2.00910654
91Myositis (HP:0100614)2.00629176
92Leukocytosis (HP:0001974)2.00543784
93Subacute progressive viral hepatitis (HP:0006572)2.00440723
94Nephritis (HP:0000123)1.99872190
95Eczematoid dermatitis (HP:0000976)1.99777353
96Abnormality of fatty-acid metabolism (HP:0004359)1.99624344
97IgG deficiency (HP:0004315)1.99568600
98Interstitial pulmonary disease (HP:0006530)1.98813966
99Esophageal varix (HP:0002040)1.97285874
100Restrictive lung disease (HP:0002091)1.94986180
101Papilloma (HP:0012740)1.94813774
102Verrucae (HP:0200043)1.94813774
103Cerebral hemorrhage (HP:0001342)1.94095268
104Abnormality of the peritoneum (HP:0002585)1.93556031
105Abnormality of skeletal muscle fiber size (HP:0012084)1.93244113
106Encephalitis (HP:0002383)1.93059325
107Panhypogammaglobulinemia (HP:0003139)1.92542554
108Keratoconjunctivitis sicca (HP:0001097)1.92190233
109Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.91971604
110Peritonitis (HP:0002586)1.91515114
111Recurrent gram-negative bacterial infections (HP:0005420)1.90899845
112Dysostosis multiplex (HP:0000943)1.90794537
113Urticaria (HP:0001025)1.89255858
114Slow saccadic eye movements (HP:0000514)1.88528625
115Hyporeflexia of lower limbs (HP:0002600)1.87578145
116Thrombophlebitis (HP:0004418)1.87464269
117Thick nail (HP:0001805)1.86942282
118Vascular tortuosity (HP:0004948)1.86698164
119Acanthosis nigricans (HP:0000956)1.86577294
120Arterial thrombosis (HP:0004420)1.86086519
121Exercise-induced myalgia (HP:0003738)1.85869596
122Recurrent abscess formation (HP:0002722)1.84304700
123Abnormality of the intrinsic pathway (HP:0010989)1.83788085
124Vasculitis (HP:0002633)1.83399171
125Hemorrhage of the eye (HP:0011885)1.83015936
126Broad metatarsal (HP:0001783)1.82932676
127Hypobetalipoproteinemia (HP:0003563)1.82690981
128Periodontitis (HP:0000704)1.82160918
129Abnormality of T cell number (HP:0011839)1.81367872
130Hypertriglyceridemia (HP:0002155)1.81338153
131Pulmonary infiltrates (HP:0002113)1.81044117
132T lymphocytopenia (HP:0005403)1.80509695
133Abnormality of purine metabolism (HP:0004352)1.80185071
134Glomerulopathy (HP:0100820)1.78471593
135Epistaxis (HP:0000421)1.78140762
136Chronic otitis media (HP:0000389)1.78040407
137Abnormality of eosinophils (HP:0001879)1.78022370
138Abnormality of cells of the lymphoid lineage (HP:0012140)1.77897874
139Hypergammaglobulinemia (HP:0010702)1.77146560
140Glucose intolerance (HP:0000833)1.76702479
141Lymphopenia (HP:0001888)1.76511629
142Abnormality of the pleura (HP:0002103)1.76477555
143Vertebral compression fractures (HP:0002953)1.76383244
144Abnormality of serine family amino acid metabolism (HP:0010894)1.76192904
145Abnormality of glycine metabolism (HP:0010895)1.76192904
146Increased variability in muscle fiber diameter (HP:0003557)1.75819817
147Hyperinsulinemic hypoglycemia (HP:0000825)1.75768680
148Steatorrhea (HP:0002570)1.75569587
149Recurrent skin infections (HP:0001581)1.74906306
150Gastrointestinal stroma tumor (HP:0100723)1.74830136
151Aortic dissection (HP:0002647)1.74204790
152Increased IgE level (HP:0003212)1.73446438
153Vacuolated lymphocytes (HP:0001922)1.71801255
154Abnormality of aspartate family amino acid metabolism (HP:0010899)1.69268148
155Keratoconjunctivitis (HP:0001096)1.68954767
156Symptomatic seizures (HP:0011145)1.67721742
157Urinary glycosaminoglycan excretion (HP:0003541)1.67351565
158Mucopolysacchariduria (HP:0008155)1.67351565
159Protuberant abdomen (HP:0001538)1.65696737
160Autoimmune thrombocytopenia (HP:0001973)1.65175275
161Abnormal platelet volume (HP:0011876)1.65156391
162Increased mean platelet volume (HP:0011877)1.63065450
163Pigmentary retinal degeneration (HP:0001146)1.62095003
164Right ventricular cardiomyopathy (HP:0011663)1.61838194
165Chronic diarrhea (HP:0002028)1.61059628
166Arterial tortuosity (HP:0005116)1.60483521
167Hemoptysis (HP:0002105)1.59954774

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.01143238
2TXK2.52547858
3BMPR22.23874831
4TGFBR22.21451919
5EPHB12.12213877
6SIK12.09398627
7FRK2.07729634
8JAK12.07310974
9FGFR22.03073028
10MAP3K142.02677107
11TYK21.97694597
12MAP3K131.91344429
13CAMK1D1.89714267
14INSRR1.87678610
15MAP2K31.75722325
16FGFR41.74805436
17ERN11.74286913
18TAOK31.68447106
19CAMK1G1.61975289
20IRAK31.58248555
21MAP4K11.49782361
22RIPK41.46875450
23IKBKE1.42904180
24JAK31.41386883
25TBK11.30738798
26SCYL21.29947069
27JAK21.29893738
28STK391.29453016
29FGFR31.28791292
30NEK91.28503506
31TIE11.26032412
32ITK1.23734455
33PIK3CA1.21610145
34OBSCN1.21112177
35EIF2AK31.19619744
36MST1R1.18326876
37MAP3K71.16431793
38MOS1.15678524
39CDK121.14394801
40TRIB31.14117721
41CSK1.11762906
42OXSR11.10184053
43BCKDK1.09657549
44PRKCQ1.09214500
45PIK3CG1.07516887
46MAP3K21.07511414
47TTN1.06046370
48TRPM71.05123614
49PTK61.03993743
50CSF1R1.02827114
51PRKCH1.02260212
52DDR20.99697011
53MAPK150.96206801
54PDPK10.95938822
55MET0.94899942
56RIPK10.93753900
57PDK10.93109011
58GRK60.92174228
59KIT0.91806506
60MAPKAPK50.91300107
61DMPK0.91094750
62IKBKB0.90900933
63TEC0.90650558
64LYN0.90094335
65PRKAA20.89619347
66WNK10.89058414
67PDGFRB0.88938557
68MELK0.87676364
69PKN10.87062599
70HIPK20.84654681
71BLK0.84627255
72MARK30.84365111
73MAPK70.82076870
74NUAK10.79779901
75STK100.79681858
76PRKD10.78180408
77MAPK120.77715380
78TNK20.77404707
79LCK0.75693872
80IRAK40.74703775
81GRK70.73954356
82KSR20.72965553
83CHUK0.72900086
84TAOK20.72538400
85FES0.72061960
86CLK10.71891200
87CAMKK20.71854679
88HCK0.68649260
89RET0.67986926
90CDC42BPA0.67542515
91PIM10.67411068
92SIK30.66092285
93SGK20.65856019
94MAP3K10.64991299
95EPHA30.64889237
96LRRK20.64797168
97FGR0.64634256
98PDGFRA0.63670759
99BTK0.63207087
100MST40.63031289
101ZAP700.63003623
102PTK2B0.62721919
103RAF10.61242297
104SYK0.59607453
105NLK0.59580010
106LMTK20.58914022
107NTRK10.58013086
108CASK0.55337212
109IGF1R0.54925837
110* MAPK110.54568444
111MAP3K30.54182528
112STK240.53641602
113SGK30.52739361
114IRAK10.52631630
115GSK3A0.52566991
116FLT30.52211312
117AKT30.50574591
118CDK60.48612460
119FYN0.47004715
120PRKCE0.46916183
121ABL10.46593868
122PKN20.46501718
123CDK40.46458117
124WNK40.46219223
125DAPK20.44843192
126INSR0.44840196
127MAPKAPK20.41887741
128BRD40.41268418
129STK380.37831923
130CCNB10.34368465
131STK30.33567913
132YES10.33367563
133ARAF0.33184321
134MAP3K50.31520208

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.36837917
2Graft-versus-host disease_Homo sapiens_hsa053322.46701382
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.43958022
4Caffeine metabolism_Homo sapiens_hsa002322.41974651
5Staphylococcus aureus infection_Homo sapiens_hsa051502.24540697
6Type I diabetes mellitus_Homo sapiens_hsa049401.90278498
7Fatty acid degradation_Homo sapiens_hsa000711.83742863
8Complement and coagulation cascades_Homo sapiens_hsa046101.80812385
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.74634023
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73552657
11Viral myocarditis_Homo sapiens_hsa054161.72311287
12PPAR signaling pathway_Homo sapiens_hsa033201.71300087
13Influenza A_Homo sapiens_hsa051641.65692936
14Tryptophan metabolism_Homo sapiens_hsa003801.64326821
15Arginine biosynthesis_Homo sapiens_hsa002201.60191903
16Propanoate metabolism_Homo sapiens_hsa006401.59510268
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.58405896
18Antigen processing and presentation_Homo sapiens_hsa046121.55999006
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.52884516
20Fatty acid metabolism_Homo sapiens_hsa012121.49695289
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.47093566
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.44542100
23Hepatitis B_Homo sapiens_hsa051611.41195712
24Herpes simplex infection_Homo sapiens_hsa051681.39209845
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37077567
26Acute myeloid leukemia_Homo sapiens_hsa052211.33687685
27Sulfur metabolism_Homo sapiens_hsa009201.33424228
28Fatty acid elongation_Homo sapiens_hsa000621.33102823
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.32072626
30ABC transporters_Homo sapiens_hsa020101.31575965
31Non-small cell lung cancer_Homo sapiens_hsa052231.31415870
32Histidine metabolism_Homo sapiens_hsa003401.27395049
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.24854703
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.24045757
35Bile secretion_Homo sapiens_hsa049761.23420344
36Pancreatic cancer_Homo sapiens_hsa052121.23353500
37Peroxisome_Homo sapiens_hsa041461.22544779
38Chronic myeloid leukemia_Homo sapiens_hsa052201.21453206
39Legionellosis_Homo sapiens_hsa051341.20849412
40Butanoate metabolism_Homo sapiens_hsa006501.18828652
41Fatty acid biosynthesis_Homo sapiens_hsa000611.11995313
42Other glycan degradation_Homo sapiens_hsa005111.11698539
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.11378603
44Small cell lung cancer_Homo sapiens_hsa052221.10923662
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08027215
46Apoptosis_Homo sapiens_hsa042101.05240796
47beta-Alanine metabolism_Homo sapiens_hsa004101.00677119
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00585040
49Prolactin signaling pathway_Homo sapiens_hsa049170.99498864
50Osteoclast differentiation_Homo sapiens_hsa043800.99108426
51Chemical carcinogenesis_Homo sapiens_hsa052040.98705826
52Renal cell carcinoma_Homo sapiens_hsa052110.98370624
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97801743
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.95539261
55Starch and sucrose metabolism_Homo sapiens_hsa005000.94249343
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94163391
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.93480665
58Leishmaniasis_Homo sapiens_hsa051400.91405424
59Fat digestion and absorption_Homo sapiens_hsa049750.91032918
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.90952652
61Retinol metabolism_Homo sapiens_hsa008300.89958279
62Malaria_Homo sapiens_hsa051440.89950284
63Shigellosis_Homo sapiens_hsa051310.89809740
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86930057
65Phagosome_Homo sapiens_hsa041450.86382072
66mTOR signaling pathway_Homo sapiens_hsa041500.85964354
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85114282
68Autoimmune thyroid disease_Homo sapiens_hsa053200.84192928
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.83613321
70Viral carcinogenesis_Homo sapiens_hsa052030.82416479
71Insulin resistance_Homo sapiens_hsa049310.79482895
72FoxO signaling pathway_Homo sapiens_hsa040680.78846523
73Pertussis_Homo sapiens_hsa051330.77811329
74Glycerolipid metabolism_Homo sapiens_hsa005610.76921372
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75813192
76Renin secretion_Homo sapiens_hsa049240.75778790
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.75548306
78B cell receptor signaling pathway_Homo sapiens_hsa046620.75133585
79Prostate cancer_Homo sapiens_hsa052150.74419773
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74391776
81African trypanosomiasis_Homo sapiens_hsa051430.73948638
82HTLV-I infection_Homo sapiens_hsa051660.73414292
83VEGF signaling pathway_Homo sapiens_hsa043700.73223119
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.71349578
85Glioma_Homo sapiens_hsa052140.69021273
86Epstein-Barr virus infection_Homo sapiens_hsa051690.68191274
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66808822
88Salmonella infection_Homo sapiens_hsa051320.66569042
89Proteoglycans in cancer_Homo sapiens_hsa052050.66242945
90Allograft rejection_Homo sapiens_hsa053300.66136786
91T cell receptor signaling pathway_Homo sapiens_hsa046600.65649245
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65250967
93Inositol phosphate metabolism_Homo sapiens_hsa005620.65023809
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64803028
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64731034
96Toxoplasmosis_Homo sapiens_hsa051450.64645216
97Platelet activation_Homo sapiens_hsa046110.64416350
98HIF-1 signaling pathway_Homo sapiens_hsa040660.63826594
99Pancreatic secretion_Homo sapiens_hsa049720.61686863
100Lysosome_Homo sapiens_hsa041420.59797335
101GnRH signaling pathway_Homo sapiens_hsa049120.59428597
102Vitamin digestion and absorption_Homo sapiens_hsa049770.58496189
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58032218
104Chemokine signaling pathway_Homo sapiens_hsa040620.56435063
105Amoebiasis_Homo sapiens_hsa051460.55820140
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.55519222
107Endometrial cancer_Homo sapiens_hsa052130.55399074
108Primary immunodeficiency_Homo sapiens_hsa053400.55117088
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.55060636
110Bladder cancer_Homo sapiens_hsa052190.54765470
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53383470
112Hematopoietic cell lineage_Homo sapiens_hsa046400.53324521
113Type II diabetes mellitus_Homo sapiens_hsa049300.52959701
114Phenylalanine metabolism_Homo sapiens_hsa003600.52928242
115Circadian rhythm_Homo sapiens_hsa047100.52422238
116MAPK signaling pathway_Homo sapiens_hsa040100.52116468
117Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51987838
118Salivary secretion_Homo sapiens_hsa049700.50820810
119ECM-receptor interaction_Homo sapiens_hsa045120.50245031
120Gastric acid secretion_Homo sapiens_hsa049710.50011727
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49714411
122Asthma_Homo sapiens_hsa053100.49362716
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.48840187
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48333177
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46919241
126Tuberculosis_Homo sapiens_hsa051520.46390867
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45637610
128MicroRNAs in cancer_Homo sapiens_hsa052060.45518982
129Systemic lupus erythematosus_Homo sapiens_hsa053220.45034370
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44249155
131Jak-STAT signaling pathway_Homo sapiens_hsa046300.44205671
132Endocytosis_Homo sapiens_hsa041440.44110396
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43856298
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43852786
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43599022
136Long-term potentiation_Homo sapiens_hsa047200.43351273
137Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42866164
138TNF signaling pathway_Homo sapiens_hsa046680.42658979
139Tyrosine metabolism_Homo sapiens_hsa003500.42166240
140Steroid biosynthesis_Homo sapiens_hsa001000.42094597
141ErbB signaling pathway_Homo sapiens_hsa040120.42005806
142Insulin signaling pathway_Homo sapiens_hsa049100.41698854
143Dorso-ventral axis formation_Homo sapiens_hsa043200.41658388
144Protein digestion and absorption_Homo sapiens_hsa049740.41459018
145Measles_Homo sapiens_hsa051620.41016756
146Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40711203
147Prion diseases_Homo sapiens_hsa050200.40158615
148Vascular smooth muscle contraction_Homo sapiens_hsa042700.40137550
149Hepatitis C_Homo sapiens_hsa051600.38884065
150cAMP signaling pathway_Homo sapiens_hsa040240.37130973
151Focal adhesion_Homo sapiens_hsa045100.36743333
152Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35947441
153AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35452927
154Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34240084
155cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34236513
156Pyruvate metabolism_Homo sapiens_hsa006200.33904626
157Glycosaminoglycan degradation_Homo sapiens_hsa005310.32461112
158Rheumatoid arthritis_Homo sapiens_hsa053230.32394868
159Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30771637

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