NR3C2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.13501204
2ionotropic glutamate receptor signaling pathway (GO:0035235)4.94289401
3vocalization behavior (GO:0071625)4.87582334
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.86270223
5glutamate receptor signaling pathway (GO:0007215)4.76670072
6regulation of glutamate receptor signaling pathway (GO:1900449)4.48098830
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.47505643
8locomotory exploration behavior (GO:0035641)4.47200280
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.36026987
10synaptic vesicle exocytosis (GO:0016079)4.27428336
11synaptic transmission, glutamatergic (GO:0035249)4.27150305
12glutamate secretion (GO:0014047)4.26614519
13G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.24999679
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.19927050
15regulation of neuronal synaptic plasticity (GO:0048168)4.17432300
16positive regulation of synapse maturation (GO:0090129)4.15197992
17protein localization to synapse (GO:0035418)4.08724839
18synaptic vesicle maturation (GO:0016188)3.95530057
19neurotransmitter-gated ion channel clustering (GO:0072578)3.92443435
20regulation of long-term neuronal synaptic plasticity (GO:0048169)3.90236042
21NADH metabolic process (GO:0006734)3.89839309
22long-term memory (GO:0007616)3.86526874
23neuron-neuron synaptic transmission (GO:0007270)3.84623461
24exploration behavior (GO:0035640)3.80635398
25regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.79861633
26cellular potassium ion homeostasis (GO:0030007)3.79720659
27cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.78031077
28behavioral defense response (GO:0002209)3.77640469
29behavioral fear response (GO:0001662)3.77640469
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.69365369
31synaptic vesicle docking involved in exocytosis (GO:0016081)3.64626477
32regulation of excitatory postsynaptic membrane potential (GO:0060079)3.64587224
33regulation of synaptic plasticity (GO:0048167)3.55692505
34macroautophagy (GO:0016236)3.53602986
35gamma-aminobutyric acid signaling pathway (GO:0007214)3.48729744
36cell communication by electrical coupling (GO:0010644)3.46417500
37regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.44375211
38regulation of postsynaptic membrane potential (GO:0060078)3.41062648
39fear response (GO:0042596)3.38992715
40angiotensin maturation (GO:0002003)3.38373048
41regulation of synaptic vesicle exocytosis (GO:2000300)3.38064310
42neuronal action potential propagation (GO:0019227)3.37820066
43dendritic spine organization (GO:0097061)3.37659414
44regulation of synaptic vesicle transport (GO:1902803)3.36611356
45long-term synaptic potentiation (GO:0060291)3.33477688
46sodium ion export (GO:0071436)3.33030509
47regulation of dendritic spine morphogenesis (GO:0061001)3.32322633
48labyrinthine layer development (GO:0060711)3.28766645
49dendritic spine morphogenesis (GO:0060997)3.26463400
50response to histamine (GO:0034776)3.25615791
51regulation of synapse maturation (GO:0090128)3.22649639
52neurotransmitter secretion (GO:0007269)3.22627031
53neuron recognition (GO:0008038)3.22581733
54regulation of synapse structural plasticity (GO:0051823)3.22419909
55membrane depolarization during action potential (GO:0086010)3.20232058
56regulation of synaptic transmission, glutamatergic (GO:0051966)3.19926090
57serotonin metabolic process (GO:0042428)3.19284958
58regulation of type B pancreatic cell apoptotic process (GO:2000674)3.18879404
59neuron cell-cell adhesion (GO:0007158)3.18855375
60transmission of nerve impulse (GO:0019226)3.16428436
61positive regulation of dendritic spine morphogenesis (GO:0061003)3.16086337
62innervation (GO:0060384)3.15483442
63positive regulation of membrane potential (GO:0045838)3.15465412
64skeletal muscle adaptation (GO:0043501)3.15431473
65relaxation of cardiac muscle (GO:0055119)3.13218145
66regulation of bile acid biosynthetic process (GO:0070857)3.12959891
67ventricular cardiac muscle cell action potential (GO:0086005)3.11284743
68gamma-aminobutyric acid transport (GO:0015812)3.07806381
69intestinal absorption (GO:0050892)3.07297558
70histone H3-K36 demethylation (GO:0070544)3.06660829
71regulation of ARF protein signal transduction (GO:0032012)3.06382569
72startle response (GO:0001964)3.05260912
73inner ear receptor cell development (GO:0060119)3.02751022
74renal absorption (GO:0070293)3.02195896
75axonal fasciculation (GO:0007413)2.99419981
76negative regulation of hormone metabolic process (GO:0032351)2.98988743
77G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.98825274
78membrane depolarization (GO:0051899)2.98265854
79long term synaptic depression (GO:0060292)2.97337866
80chemosensory behavior (GO:0007635)2.95757090
81regulation of vesicle fusion (GO:0031338)2.94656952
82dendrite morphogenesis (GO:0048813)2.93993877
83negative regulation of hormone biosynthetic process (GO:0032353)2.93016790
84positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.91033954
85positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.90536390
86regulation of guanylate cyclase activity (GO:0031282)2.90437065
87negative regulation of synaptic transmission, GABAergic (GO:0032229)2.90287775
88learning (GO:0007612)2.88303925
89regulation of relaxation of muscle (GO:1901077)2.87322943
90primary amino compound metabolic process (GO:1901160)2.87265044
91cell communication involved in cardiac conduction (GO:0086065)2.87226091
92regulation of glutamate secretion (GO:0014048)2.86762786
93synaptic vesicle endocytosis (GO:0048488)2.86151818
94positive regulation of dendritic spine development (GO:0060999)2.85454137
95regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.85190814
96cellular glucuronidation (GO:0052695)2.81945341
97glucan catabolic process (GO:0009251)2.81548747
98regulation of cholesterol homeostasis (GO:2000188)2.79977655
99proline transport (GO:0015824)2.79078634
100detection of calcium ion (GO:0005513)2.78995493
101regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.78851191
102negative regulation of amino acid transport (GO:0051956)2.78249947
103positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.78079918
104regulation of synaptic transmission (GO:0050804)2.77375229
105central nervous system projection neuron axonogenesis (GO:0021952)2.77144950
106activation of protein kinase A activity (GO:0034199)2.75625385
107regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.74996049
108endocrine process (GO:0050886)2.74996049
109regulation of systemic arterial blood pressure by hormone (GO:0001990)2.74996049
110oocyte development (GO:0048599)2.74278139
111regulation of acrosome reaction (GO:0060046)2.73857505
112sarcoplasmic reticulum calcium ion transport (GO:0070296)2.73293248
113neurotransmitter transport (GO:0006836)2.73148557
114regulation of dendritic spine development (GO:0060998)2.73106050
115regulation of cell communication by electrical coupling (GO:0010649)2.71754533
116sulfate transmembrane transport (GO:1902358)2.70572902
117synaptic transmission (GO:0007268)2.68448263
118bundle of His cell to Purkinje myocyte communication (GO:0086069)2.66429150
119actin-myosin filament sliding (GO:0033275)2.64966852
120muscle filament sliding (GO:0030049)2.64966852
121epoxygenase P450 pathway (GO:0019373)2.64904985
122cochlea development (GO:0090102)2.64667540
123regulation of female receptivity (GO:0045924)2.62355417
124cerebellar Purkinje cell differentiation (GO:0021702)2.62051618
125associative learning (GO:0008306)2.61639441
126neuromuscular process controlling balance (GO:0050885)2.60984051
127cellular polysaccharide catabolic process (GO:0044247)2.60839406
128regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.58782596
129interkinetic nuclear migration (GO:0022027)2.58397172
130lipoprotein transport (GO:0042953)2.57885677
131cGMP-mediated signaling (GO:0019934)2.57739956
132L-amino acid import (GO:0043092)2.57282857
133behavioral response to cocaine (GO:0048148)2.56839807
134* cellular sodium ion homeostasis (GO:0006883)2.56239402
135potassium ion import (GO:0010107)2.56114394
136regulation of protein glycosylation (GO:0060049)2.56064980
137regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.56046481
138positive regulation of fibroblast migration (GO:0010763)2.55082044
139regulation of neurotransmitter levels (GO:0001505)2.54648182
140regulation of p38MAPK cascade (GO:1900744)2.53996613
141citrulline biosynthetic process (GO:0019240)2.53337646
142regulation of inositol phosphate biosynthetic process (GO:0010919)2.53145570
143uronic acid metabolic process (GO:0006063)2.51917607
144glucuronate metabolic process (GO:0019585)2.51917607
145positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.51839378
146actin-mediated cell contraction (GO:0070252)2.51807955
147memory (GO:0007613)2.51560898
148regulation of energy homeostasis (GO:2000505)2.51537759
149Golgi to endosome transport (GO:0006895)2.50592883
150glycogen catabolic process (GO:0005980)2.50446821
151regulation of actin filament-based movement (GO:1903115)2.50227213
152membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.48170552
153striated muscle hypertrophy (GO:0014897)2.47828703
154striated muscle contraction (GO:0006941)2.47523494
155early endosome to late endosome transport (GO:0045022)2.47395232
156relaxation of muscle (GO:0090075)2.45886878
157striated muscle adaptation (GO:0014888)2.43951639
158actin filament-based movement (GO:0030048)2.43887382
159flavonoid metabolic process (GO:0009812)2.43870060
160cardiac muscle contraction (GO:0060048)2.43402550
161regulation of steroid hormone biosynthetic process (GO:0090030)2.41225637
162skeletal muscle contraction (GO:0003009)2.40974277
163female mating behavior (GO:0060180)2.39753668
164cardiac muscle hypertrophy (GO:0003300)2.36506386
165creatine metabolic process (GO:0006600)2.35157632
166transcytosis (GO:0045056)2.34283942
167cytoskeletal anchoring at plasma membrane (GO:0007016)2.34129114
168regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.33993789
169positive regulation of sodium ion transport (GO:0010765)2.33684107
170succinate metabolic process (GO:0006105)2.33035806
171phospholipid dephosphorylation (GO:0046839)2.32962055
172auditory receptor cell differentiation (GO:0042491)2.32537738
173energy homeostasis (GO:0097009)2.32393337
174cellular response to reactive nitrogen species (GO:1902170)2.32307782
175cardiac conduction (GO:0061337)2.32061315
176actin filament depolymerization (GO:0030042)2.31684400
177striated muscle atrophy (GO:0014891)2.30081752
178* sodium ion homeostasis (GO:0055078)2.29831763
179polysaccharide catabolic process (GO:0000272)2.29146473
180peptide hormone processing (GO:0016486)2.27878391
181regulation of skeletal muscle contraction (GO:0014819)2.27189749
182amino-acid betaine transport (GO:0015838)2.26936262
183carnitine transport (GO:0015879)2.26936262
184brain morphogenesis (GO:0048854)2.26307349
185positive regulation of guanylate cyclase activity (GO:0031284)2.25245357
186nucleus localization (GO:0051647)2.24688818

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.47564633
2GBX2_23144817_ChIP-Seq_PC3_Human3.67024803
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.92850019
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.85748795
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.80048823
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.68243067
7DROSHA_22980978_ChIP-Seq_HELA_Human2.53353925
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50468978
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46813000
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46813000
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41476869
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38049775
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35487618
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.28871288
15REST_21632747_ChIP-Seq_MESCs_Mouse2.25985666
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.24648016
17* RARB_27405468_Chip-Seq_BRAIN_Mouse2.24357274
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.15238425
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.05186191
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.02442760
21SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97287008
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.93917045
23IKZF1_21737484_ChIP-ChIP_HCT116_Human1.93364386
24CDX2_20551321_ChIP-Seq_CACO-2_Human1.91982748
25REST_18959480_ChIP-ChIP_MESCs_Mouse1.80221089
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.77929639
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77239094
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74163316
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72412703
30SMAD4_21799915_ChIP-Seq_A2780_Human1.69819518
31CTNNB1_20460455_ChIP-Seq_HCT116_Human1.69748629
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67643935
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.61040707
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.59310958
35AR_21572438_ChIP-Seq_LNCaP_Human1.57991199
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52449655
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46779670
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46776006
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.46606196
40* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46084420
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44216718
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.41470724
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40347483
44SOX2_27498859_Chip-Seq_STOMACH_Mouse1.39783807
45LXR_22158963_ChIP-Seq_LIVER_Mouse1.39160787
46FOXA2_19822575_ChIP-Seq_HepG2_Human1.38608540
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.38162739
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37644889
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36955826
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.36222660
51AR_25329375_ChIP-Seq_VCAP_Human1.34507746
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33885342
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33759175
54P300_19829295_ChIP-Seq_ESCs_Human1.31498787
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31207330
56* PIAS1_25552417_ChIP-Seq_VCAP_Human1.31077872
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.29784361
58FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29098477
59ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.28606768
60* SOX2_21211035_ChIP-Seq_LN229_Gbm1.28158936
61TAF15_26573619_Chip-Seq_HEK293_Human1.27828655
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.25930174
63* STAT3_23295773_ChIP-Seq_U87_Human1.25581421
64ZNF274_21170338_ChIP-Seq_K562_Hela1.25298804
65AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.25033704
66* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24599571
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.24532281
68TCF4_18268006_ChIP-ChIP_LS174T_Human1.23295330
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22832651
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22516015
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.22432156
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22169978
73AHR_22903824_ChIP-Seq_MCF-7_Human1.20914830
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19566081
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19399774
76TBX20_22080862_ChIP-Seq_HEART_Mouse1.18366206
77TBX20_22328084_ChIP-Seq_HEART_Mouse1.18366206
78* AR_19668381_ChIP-Seq_PC3_Human1.17748855
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17508687
80* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.16809822
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15477757
82BCAT_22108803_ChIP-Seq_LS180_Human1.15103414
83PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15051466
84IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14692212
85WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14303715
86STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.13115326
87FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.12899189
88* RING1B_27294783_Chip-Seq_ESCs_Mouse1.12445445
89TP53_16413492_ChIP-PET_HCT116_Human1.11688197
90SMAD3_21741376_ChIP-Seq_HESCs_Human1.10546443
91FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09722786
92SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09149481
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08600182
94* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08536538
95* TCF4_23295773_ChIP-Seq_U87_Human1.08053047
96* CDX2_22108803_ChIP-Seq_LS180_Human1.07429669
97SOX2_20726797_ChIP-Seq_SW620_Human1.07285889
98* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07083568
99* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06724199
100* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06289783
101* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04857901
102RXR_22108803_ChIP-Seq_LS180_Human1.04713946
103SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03855980
104* PRDM14_20953172_ChIP-Seq_ESCs_Human1.03348487
105FOXA1_25552417_ChIP-Seq_VCAP_Human1.02691243
106TP53_18474530_ChIP-ChIP_U2OS_Human1.01597881
107ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00676593
108CBX2_27304074_Chip-Seq_ESCs_Mouse1.00585874
109Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98754498
110SMAD4_21741376_ChIP-Seq_HESCs_Human0.98527157
111NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98504579
112THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98240040
113* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97182715
114RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97174662
115DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95621920
116* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95611317
117SMAD_19615063_ChIP-ChIP_OVARY_Human0.95490887
118POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95330704
119TP63_23658742_ChIP-Seq_EP156T_Human0.94452552
120VDR_22108803_ChIP-Seq_LS180_Human0.93518641
121RXR_22158963_ChIP-Seq_LIVER_Mouse0.93242101
122NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92196073
123CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92162573
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92107100
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92107100
126* RUNX2_22187159_ChIP-Seq_PCA_Human0.92091592
127GATA4_25053715_ChIP-Seq_YYC3_Human0.92022571
128* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91970071
129EP300_21415370_ChIP-Seq_HL-1_Mouse0.91631415
130NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90800892
131NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90800892
132ESR1_20079471_ChIP-ChIP_T-47D_Human0.89494595
133MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89442183
134MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89232608
135RING1B_27294783_Chip-Seq_NPCs_Mouse0.89047242
136BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88612930
137LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87505604
138RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87059639
139RUNX_20019798_ChIP-Seq_JUKART_Human0.87035518
140* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86373813
141P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86255094
142CTCF_27219007_Chip-Seq_Bcells_Human0.84885320
143EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84666359
144SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84552876
145TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84011118
146FUS_26573619_Chip-Seq_HEK293_Human0.83643647

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.12806720
2MP0003880_abnormal_central_pattern4.68202021
3* MP0003635_abnormal_synaptic_transmissio3.98256585
4MP0002822_catalepsy3.60050961
5MP0009745_abnormal_behavioral_response3.46728467
6MP0004270_analgesia3.32858410
7* MP0002063_abnormal_learning/memory/cond3.22279068
8MP0002064_seizures2.93325586
9MP0002735_abnormal_chemical_nociception2.74920250
10* MP0002572_abnormal_emotion/affect_behav2.63573996
11MP0002009_preneoplasia2.54081267
12MP0001501_abnormal_sleep_pattern2.51557721
13MP0001968_abnormal_touch/_nociception2.46397985
14MP0009046_muscle_twitch2.36245087
15MP0002272_abnormal_nervous_system2.35222755
16MP0005409_darkened_coat_color2.33187231
17MP0003868_abnormal_feces_composition2.21120100
18MP0001486_abnormal_startle_reflex2.18439982
19MP0009840_abnormal_foam_cell2.17872985
20MP0001440_abnormal_grooming_behavior2.11654652
21MP0002736_abnormal_nociception_after2.08352050
22MP0003329_amyloid_beta_deposits2.08018327
23MP0009780_abnormal_chondrocyte_physiolo1.93608429
24MP0002734_abnormal_mechanical_nocicepti1.92575619
25MP0004036_abnormal_muscle_relaxation1.81419885
26MP0005423_abnormal_somatic_nervous1.72592350
27MP0002067_abnormal_sensory_capabilities1.69006006
28MP0003866_abnormal_defecation1.67635095
29MP0010352_gastrointestinal_tract_polyps1.64834718
30MP0004019_abnormal_vitamin_homeostasis1.62353174
31MP0008569_lethality_at_weaning1.61251973
32MP0002837_dystrophic_cardiac_calcinosis1.59750843
33MP0002138_abnormal_hepatobiliary_system1.59591041
34MP0004858_abnormal_nervous_system1.59420004
35MP0004147_increased_porphyrin_level1.58508881
36MP0001970_abnormal_pain_threshold1.56199138
37MP0003045_fibrosis1.54464559
38MP0003879_abnormal_hair_cell1.53861674
39MP0002909_abnormal_adrenal_gland1.52790291
40MP0004264_abnormal_extraembryonic_tissu1.51669819
41MP0002733_abnormal_thermal_nociception1.51547640
42MP0003787_abnormal_imprinting1.50869960
43MP0000778_abnormal_nervous_system1.48954473
44MP0005085_abnormal_gallbladder_physiolo1.48095215
45MP0010678_abnormal_skin_adnexa1.44367424
46MP0002557_abnormal_social/conspecific_i1.43135757
47MP0005670_abnormal_white_adipose1.42337766
48MP0005360_urolithiasis1.40261381
49MP0004924_abnormal_behavior1.39554167
50MP0005386_behavior/neurological_phenoty1.39554167
51MP0002184_abnormal_innervation1.39524751
52MP0005646_abnormal_pituitary_gland1.38666636
53MP0002971_abnormal_brown_adipose1.38466341
54MP0000751_myopathy1.36043245
55MP0001502_abnormal_circadian_rhythm1.34471108
56MP0003075_altered_response_to1.33388891
57MP0001756_abnormal_urination1.33176571
58MP0010368_abnormal_lymphatic_system1.32990701
59MP0004811_abnormal_neuron_physiology1.32478595
60MP0004885_abnormal_endolymph1.30155633
61MP0005332_abnormal_amino_acid1.29197860
62MP0003633_abnormal_nervous_system1.28545714
63MP0004087_abnormal_muscle_fiber1.28449960
64MP0002106_abnormal_muscle_physiology1.26748621
65MP0001905_abnormal_dopamine_level1.22950308
66MP0010234_abnormal_vibrissa_follicle1.22112652
67MP0008875_abnormal_xenobiotic_pharmacok1.21473655
68MP0004084_abnormal_cardiac_muscle1.19665436
69MP0005365_abnormal_bile_salt1.19518465
70MP0005166_decreased_susceptibility_to1.18905911
71MP0002066_abnormal_motor_capabilities/c1.18728737
72MP0002139_abnormal_hepatobiliary_system1.18225918
73MP0004142_abnormal_muscle_tone1.18095770
74MP0002882_abnormal_neuron_morphology1.17365843
75MP0010386_abnormal_urinary_bladder1.17160639
76MP0004215_abnormal_myocardial_fiber1.16844806
77MP0005551_abnormal_eye_electrophysiolog1.15377900
78MP0002876_abnormal_thyroid_physiology1.13615180
79MP0000747_muscle_weakness1.12605516
80MP0000604_amyloidosis1.12283439
81MP0000003_abnormal_adipose_tissue1.11304788
82MP0000955_abnormal_spinal_cord1.10476076
83MP0001984_abnormal_olfaction1.10224163
84MP0006138_congestive_heart_failure1.10084256
85MP0003631_nervous_system_phenotype1.07655418
86MP0000681_abnormal_thyroid_gland1.06306266
87MP0000230_abnormal_systemic_arterial1.05648857
88MP0002269_muscular_atrophy1.05646218
89MP0005330_cardiomyopathy1.05212751
90MP0005369_muscle_phenotype1.03582454
91MP0010155_abnormal_intestine_physiology1.02595868
92MP0005666_abnormal_adipose_tissue1.00008188
93MP0004484_altered_response_of0.99858266
94MP0003300_gastrointestinal_ulcer0.99477962
95MP0002078_abnormal_glucose_homeostasis0.97753000
96MP0005375_adipose_tissue_phenotype0.97501252
97MP0006276_abnormal_autonomic_nervous0.96880934
98MP0002896_abnormal_bone_mineralization0.96521323
99* MP0009643_abnormal_urine_homeostasis0.96127093
100MP0005535_abnormal_body_temperature0.95739104
101MP0002118_abnormal_lipid_homeostasis0.95722191
102MP0004085_abnormal_heartbeat0.94217470
103* MP0001765_abnormal_ion_homeostasis0.94088307
104MP0002229_neurodegeneration0.93486986
105MP0004043_abnormal_pH_regulation0.93202926
106MP0008874_decreased_physiological_sensi0.92965400
107MP0003718_maternal_effect0.92785424
108MP0001177_atelectasis0.92334836
109MP0002972_abnormal_cardiac_muscle0.92147485
110MP0000759_abnormal_skeletal_muscle0.89888832
111MP0002069_abnormal_eating/drinking_beha0.89286051
112MP0008872_abnormal_physiological_respon0.88704918
113MP0000383_abnormal_hair_follicle0.88457805
114MP0002127_abnormal_cardiovascular_syste0.86812242
115MP0001188_hyperpigmentation0.86156169
116MP0001664_abnormal_digestion0.85542630
117MP0004130_abnormal_muscle_cell0.84170640
118MP0003690_abnormal_glial_cell0.84040645
119MP0005448_abnormal_energy_balance0.83710530
120MP0002166_altered_tumor_susceptibility0.83247201
121MP0002332_abnormal_exercise_endurance0.82735770
122MP0010329_abnormal_lipoprotein_level0.82590445
123MP0004145_abnormal_muscle_electrophysio0.81601016
124MP0002090_abnormal_vision0.80262561
125MP0009115_abnormal_fat_cell0.79858022
126MP0001299_abnormal_eye_distance/0.79380466
127* MP0002152_abnormal_brain_morphology0.79120254
128MP0003091_abnormal_cell_migration0.78766419
129MP0008961_abnormal_basal_metabolism0.77846461
130MP0003632_abnormal_nervous_system0.77713396
131MP0005385_cardiovascular_system_phenoty0.77005700
132MP0001544_abnormal_cardiovascular_syste0.77005700
133MP0004510_myositis0.76911690
134MP0000465_gastrointestinal_hemorrhage0.76498338
135MP0003252_abnormal_bile_duct0.74814729
136MP0000477_abnormal_intestine_morphology0.74699029
137MP0005171_absent_coat_pigmentation0.72122613
138MP0001963_abnormal_hearing_physiology0.71578049
139MP0003137_abnormal_impulse_conducting0.71341211
140MP0005595_abnormal_vascular_smooth0.70897946
141MP0001529_abnormal_vocalization0.67746033
142MP0005620_abnormal_muscle_contractility0.66451413
143MP0005645_abnormal_hypothalamus_physiol0.65261203
144MP0001485_abnormal_pinna_reflex0.64351132
145MP0005187_abnormal_penis_morphology0.63874528
146MP0001666_abnormal_nutrient_absorption0.63710685
147MP0003646_muscle_fatigue0.61992245
148MP0003183_abnormal_peptide_metabolism0.61668329
149MP0000013_abnormal_adipose_tissue0.61505746
150MP0000749_muscle_degeneration0.61233974
151MP0004233_abnormal_muscle_weight0.60063634
152MP0002234_abnormal_pharynx_morphology0.59290022
153MP0005167_abnormal_blood-brain_barrier0.59213983

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.09780423
2Myokymia (HP:0002411)6.15276414
3Focal seizures (HP:0007359)5.33487340
4Visual hallucinations (HP:0002367)4.67772235
5Epileptic encephalopathy (HP:0200134)4.65513906
6Progressive cerebellar ataxia (HP:0002073)4.34444375
7Hyperventilation (HP:0002883)4.33920227
8Atonic seizures (HP:0010819)4.24849142
9Febrile seizures (HP:0002373)4.21699987
10* Hyperkalemia (HP:0002153)4.18703888
11Abnormality of chloride homeostasis (HP:0011422)4.17283098
12Absence seizures (HP:0002121)4.11359125
13Muscle fiber inclusion bodies (HP:0100299)4.05017812
14Dialeptic seizures (HP:0011146)3.96520758
15Nemaline bodies (HP:0003798)3.91065505
16Malnutrition (HP:0004395)3.90288433
17Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.85832032
18Generalized tonic-clonic seizures (HP:0002069)3.72267903
19Abnormality of glutamine family amino acid metabolism (HP:0010902)3.68923945
20Abnormality of the lower motor neuron (HP:0002366)3.68218912
21* Hyperactive renin-angiotensin system (HP:0000841)3.67002983
22Action tremor (HP:0002345)3.60626980
23Nuclear cataract (HP:0100018)3.59772194
24* Abnormality of potassium homeostasis (HP:0011042)3.45388237
25Dysmetria (HP:0001310)3.34801409
26Rectal prolapse (HP:0002035)3.25308317
27Amblyopia (HP:0000646)3.24106349
28Gaze-evoked nystagmus (HP:0000640)3.13998657
29Dysdiadochokinesis (HP:0002075)3.12945904
30Type 1 muscle fiber predominance (HP:0003803)3.10008504
31Epileptiform EEG discharges (HP:0011182)3.05902159
32Broad-based gait (HP:0002136)3.02332742
33Hypokalemia (HP:0002900)3.00816024
34Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.97511107
35Papillary thyroid carcinoma (HP:0002895)2.88236438
36Impaired vibration sensation in the lower limbs (HP:0002166)2.86999335
37Hyporeflexia of lower limbs (HP:0002600)2.85538210
38Cerebral inclusion bodies (HP:0100314)2.84530232
39Anxiety (HP:0000739)2.84296004
40Double outlet right ventricle (HP:0001719)2.80995206
41Congenital malformation of the right heart (HP:0011723)2.80995206
42Genetic anticipation (HP:0003743)2.80555515
43Excessive salivation (HP:0003781)2.80270749
44Drooling (HP:0002307)2.80270749
45* Abnormality of renin-angiotensin system (HP:0000847)2.80070058
46Abnormal social behavior (HP:0012433)2.79816587
47Impaired social interactions (HP:0000735)2.79816587
48Syncope (HP:0001279)2.78936239
49Scanning speech (HP:0002168)2.78848209
50Hematochezia (HP:0002573)2.78189160
51Hyperphosphatemia (HP:0002905)2.77899492
52Muscle fiber splitting (HP:0003555)2.75482159
53Supranuclear gaze palsy (HP:0000605)2.75476329
54Postural instability (HP:0002172)2.73668745
55Flat acetabular roof (HP:0003180)2.72694378
56Papilledema (HP:0001085)2.71158171
57Poor eye contact (HP:0000817)2.71061667
58Ventricular fibrillation (HP:0001663)2.69197333
59Exercise-induced myalgia (HP:0003738)2.68146046
60Heart block (HP:0012722)2.67146546
61Depression (HP:0000716)2.66566989
62EMG: myopathic abnormalities (HP:0003458)2.66046003
63Truncal ataxia (HP:0002078)2.65079223
64Fat malabsorption (HP:0002630)2.60022533
65Asymmetric septal hypertrophy (HP:0001670)2.55339513
66Neurofibrillary tangles (HP:0002185)2.53988089
67Abnormal atrioventricular conduction (HP:0005150)2.52415789
68EEG with generalized epileptiform discharges (HP:0011198)2.52377622
69Confusion (HP:0001289)2.44382365
70Abnormal biliary tract morphology (HP:0012440)2.42729874
71Abnormality of monocarboxylic acid metabolism (HP:0010996)2.41787130
72Status epilepticus (HP:0002133)2.41208293
73Dysmetric saccades (HP:0000641)2.35462659
74Subaortic stenosis (HP:0001682)2.34843252
75Abnormality of the left ventricular outflow tract (HP:0011103)2.34843252
76Hemiparesis (HP:0001269)2.33569046
77Hypsarrhythmia (HP:0002521)2.32307268
78Intention tremor (HP:0002080)2.32216379
79Difficulty running (HP:0009046)2.31050124
80Impaired smooth pursuit (HP:0007772)2.30425229
81Abnormal eating behavior (HP:0100738)2.29141762
82Bundle branch block (HP:0011710)2.29100043
83Abnormality of vitamin B metabolism (HP:0004340)2.27028723
84Thickened helices (HP:0000391)2.27011001
85Biliary tract neoplasm (HP:0100574)2.26991150
86Centrally nucleated skeletal muscle fibers (HP:0003687)2.26983514
87Absent speech (HP:0001344)2.24355258
88Neck muscle weakness (HP:0000467)2.23939239
89Distal arthrogryposis (HP:0005684)2.23723694
90Exercise-induced muscle cramps (HP:0003710)2.22794196
91Abnormal glucose tolerance (HP:0001952)2.21459798
92Sudden death (HP:0001699)2.20954274
93Hemiplegia (HP:0002301)2.20133929
94Chronic diarrhea (HP:0002028)2.19673225
95Ileus (HP:0002595)2.19359038
96Muscle hypertrophy of the lower extremities (HP:0008968)2.18471936
97Hydroxyprolinuria (HP:0003080)2.17649216
98Abnormality of proline metabolism (HP:0010907)2.17649216
99Urinary bladder sphincter dysfunction (HP:0002839)2.17313290
100Alkalosis (HP:0001948)2.16649226
101Blue irides (HP:0000635)2.15213825
102Congenital sensorineural hearing impairment (HP:0008527)2.15158731
103Stereotypic behavior (HP:0000733)2.12576747
104Bradykinesia (HP:0002067)2.12501072
105* Decreased circulating renin level (HP:0003351)2.11322444
106Diplopia (HP:0000651)2.09918875
107Abnormality of binocular vision (HP:0011514)2.09918875
108Generalized myoclonic seizures (HP:0002123)2.08253610
109Impaired vibratory sensation (HP:0002495)2.06927019
110Ventricular tachycardia (HP:0004756)2.03950234
111Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.03861240
112Focal dystonia (HP:0004373)2.03627594
113Abnormal EKG (HP:0003115)2.03558228
114Torticollis (HP:0000473)2.02421289
115Abnormality of vitamin metabolism (HP:0100508)2.00892380
116Neoplasm of the small intestine (HP:0100833)2.00756762
117Abnormality of the calf musculature (HP:0001430)2.00205948
118Proximal tubulopathy (HP:0000114)2.00008790
119Abnormality of the vitamin B12 metabolism (HP:0004341)1.98595865
120Calf muscle hypertrophy (HP:0008981)1.98259555
121Atrioventricular block (HP:0001678)1.97333348
122Round ear (HP:0100830)1.96321693
123Choroideremia (HP:0001139)1.95639440
124Increased connective tissue (HP:0009025)1.95067577
125Palpitations (HP:0001962)1.93768312
126Urinary urgency (HP:0000012)1.93628283
127Abnormality of ocular smooth pursuit (HP:0000617)1.93044213
128Myopathic facies (HP:0002058)1.92084584
129Prolonged QT interval (HP:0001657)1.89371060
130Incomplete penetrance (HP:0003829)1.89278288
131Glucose intolerance (HP:0000833)1.88577417
132Ankle clonus (HP:0011448)1.88061573
133Polar cataract (HP:0010696)1.87991817
134Psychosis (HP:0000709)1.87299432
135Insulin-resistant diabetes mellitus (HP:0000831)1.87103416
136Ventricular arrhythmia (HP:0004308)1.86913472
137Muscle stiffness (HP:0003552)1.85794614
138Rapidly progressive (HP:0003678)1.85666730
139Pigmentary retinal degeneration (HP:0001146)1.85431984
140Ketoacidosis (HP:0001993)1.84531137
141Lower limb asymmetry (HP:0100559)1.83734136
142Abnormality of salivation (HP:0100755)1.83035589
143Hypercortisolism (HP:0001578)1.82545209
144Protruding tongue (HP:0010808)1.82528499
145Spastic gait (HP:0002064)1.82098442
146* Adrenal overactivity (HP:0002717)1.81172990
147Zonular cataract (HP:0010920)1.80659519
148* Hyperaldosteronism (HP:0000859)1.79702756
149Visceral angiomatosis (HP:0100761)1.79467842
150Fair hair (HP:0002286)1.79195676
151Abnormality of the distal phalanx of the thumb (HP:0009617)1.78827021
152Metabolic alkalosis (HP:0200114)1.78776053
153Gait ataxia (HP:0002066)1.78323582
154Abnormality of skeletal muscle fiber size (HP:0012084)1.76336778
155Anosmia (HP:0000458)1.76331910
156Primary atrial arrhythmia (HP:0001692)1.75632211
157Central scotoma (HP:0000603)1.75516672
158Increased variability in muscle fiber diameter (HP:0003557)1.75209760
159Megalencephaly (HP:0001355)1.73816407
160Rhabdomyolysis (HP:0003201)1.73126820
161Lower limb amyotrophy (HP:0007210)1.73069395
162Mildly elevated creatine phosphokinase (HP:0008180)1.72963767
163Hypoplastic nipples (HP:0002557)1.71384156
164Oligodactyly (hands) (HP:0001180)1.70797177
165Intrahepatic cholestasis (HP:0001406)1.70394702
166Global brain atrophy (HP:0002283)1.70340484
167Myoglobinuria (HP:0002913)1.70147215
168Steatorrhea (HP:0002570)1.69728067
169Progressive sensorineural hearing impairment (HP:0000408)1.68540840
170Frequent falls (HP:0002359)1.68419933
171Lip pit (HP:0100267)1.67736128
172Atrial fibrillation (HP:0005110)1.67454646
173Ketosis (HP:0001946)1.66451396
174Craniofacial dystonia (HP:0012179)1.65737279
175Striae distensae (HP:0001065)1.65619247
176Intellectual disability, severe (HP:0010864)1.65532342
177Hip contracture (HP:0003273)1.65331503
178Distal lower limb muscle weakness (HP:0009053)1.63217577
179Progressive inability to walk (HP:0002505)1.62891614
180Retinal dysplasia (HP:0007973)1.62547817
181Right ventricular cardiomyopathy (HP:0011663)1.62270025
182Insidious onset (HP:0003587)1.61804496
183Termporal pattern (HP:0011008)1.61804496
184Supraventricular tachycardia (HP:0004755)1.59713817
185Generalized hypopigmentation of hair (HP:0011358)1.59318605

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK36.23584415
2EPHA45.83507798
3OBSCN3.69396977
4MAP2K62.67214756
5ACVR1B2.66553804
6MAP3K92.64283252
7MAP3K42.63365050
8RIPK12.49591618
9RIPK42.26530853
10MAP2K72.25163338
11NLK2.19547752
12TNIK2.13400882
13MST1R2.13352784
14MINK12.02185277
15KSR21.99237466
16PRKD31.95141615
17PRPF4B1.87332751
18PIK3CA1.80708106
19MAP2K41.79836795
20DAPK21.79445660
21CDK121.78693125
22TTN1.68303145
23KSR11.58051628
24LMTK21.56934490
25MET1.55773346
26FES1.51320589
27NTRK21.50648101
28NME11.46763849
29CAMK2B1.46309662
30PTK2B1.46068093
31MARK11.45594549
32NEK61.44077559
33MAP3K131.40718640
34PAK61.38836939
35PLK21.38282491
36MAP3K21.36021320
37CDK51.36012961
38STK381.34180727
39STK391.33382965
40DAPK11.31962943
41CAMK2A1.30532974
42IRAK41.28065666
43PIK3CG1.24358635
44MAP3K71.22129959
45CAMKK11.20915128
46STK241.20527735
47PINK11.19763770
48TRPM71.19202702
49FER1.19167717
50PRKCG1.16026534
51MAP3K121.14594927
52FGFR31.13149592
53MARK21.12529684
54CASK1.10272522
55MAPK131.10237013
56ARAF1.08287857
57INSRR1.07643666
58CAMK11.06201145
59MELK1.01402794
60JAK11.00802867
61PNCK1.00659071
62NTRK10.98589242
63PDK20.97977258
64WNK10.97033041
65PHKG20.95537933
66PHKG10.95537933
67GRK50.94724439
68SGK4940.94406479
69SGK2230.94406479
70EPHA20.93348380
71SGK20.92620358
72CAMK2D0.88019126
73MAPK110.87104978
74SIK20.86600843
75BMPR20.85997781
76PRKG20.84483177
77SGK10.83646009
78DMPK0.82763451
79RAF10.82566359
80MAP3K100.81208447
81SGK30.80578036
82TAOK20.79220037
83PAK30.77940022
84EPHB10.77397376
85FRK0.75546866
86MOS0.73616239
87PDK10.73338849
88TIE10.72948608
89PRKCE0.71771409
90MAP3K10.71622433
91CAMK2G0.70674323
92PRKAA10.69942984
93MAP2K20.69624002
94FGR0.69437787
95PRKCH0.68429429
96PDPK10.67635297
97EEF2K0.66126312
98MAP2K10.64725448
99TAOK30.64590762
100TRIB30.63136694
101LATS10.61455503
102MAPK70.61082660
103CSNK1G20.59917601
104EPHA30.59906597
105ERN10.58319327
106DYRK1A0.57082424
107AKT30.52619260
108PRKCZ0.51693858
109MYLK0.51674803
110CDC42BPA0.51405454
111TYRO30.50792587
112PRKD20.50692189
113ICK0.49858897
114PRKG10.49200609
115MUSK0.48517192
116STK110.48241662
117RET0.48115465
118CAMK1G0.47371053
119RPS6KA30.47333365
120ZAP700.47224251
121CAMK40.47162132
122CDK180.46644546
123CDK150.46248292
124PRKCA0.44828556
125UHMK10.44514687
126OXSR10.43883711
127JAK20.43825428
128CAMK1D0.43479070
129TYK20.43229877
130FYN0.43163355
131NEK90.41809560
132GRK60.41143535
133CDK140.41058103
134ROCK20.40958544
135FGFR40.40066654
136MAP3K30.38037052
137PRKAA20.37281592
138PRKACA0.36019216
139CDK11A0.35486066
140PRKCQ0.35074096
141PRKACB0.33092758
142CAMKK20.32727292
143PRKCB0.32391383
144DDR20.31413267
145BMX0.30703252
146PRKACG0.30466312
147MAPK100.30395282
148MAPK120.29846179
149PDK30.28032492

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.73318908
2Circadian entrainment_Homo sapiens_hsa047132.89297116
3Long-term potentiation_Homo sapiens_hsa047202.73911992
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.67691506
5Glutamatergic synapse_Homo sapiens_hsa047242.51711318
6Amphetamine addiction_Homo sapiens_hsa050312.46336056
7GABAergic synapse_Homo sapiens_hsa047272.45003137
8Synaptic vesicle cycle_Homo sapiens_hsa047212.22810676
9Morphine addiction_Homo sapiens_hsa050322.20506113
10Salivary secretion_Homo sapiens_hsa049702.18070509
11Olfactory transduction_Homo sapiens_hsa047402.15050331
12Caffeine metabolism_Homo sapiens_hsa002322.07121630
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.97882209
14Insulin secretion_Homo sapiens_hsa049111.91195670
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.89969837
16Dopaminergic synapse_Homo sapiens_hsa047281.87467084
17Nitrogen metabolism_Homo sapiens_hsa009101.77743835
18Gastric acid secretion_Homo sapiens_hsa049711.72888157
19Calcium signaling pathway_Homo sapiens_hsa040201.72876699
20Taste transduction_Homo sapiens_hsa047421.70507418
21Histidine metabolism_Homo sapiens_hsa003401.67176937
22Cholinergic synapse_Homo sapiens_hsa047251.67140370
23Protein digestion and absorption_Homo sapiens_hsa049741.65810654
24Renin-angiotensin system_Homo sapiens_hsa046141.62620495
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.60068315
26Renin secretion_Homo sapiens_hsa049241.58493591
27Oxytocin signaling pathway_Homo sapiens_hsa049211.56749137
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.54004528
29Long-term depression_Homo sapiens_hsa047301.48752758
30Serotonergic synapse_Homo sapiens_hsa047261.41829433
31Cocaine addiction_Homo sapiens_hsa050301.41581111
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40756962
33Vitamin digestion and absorption_Homo sapiens_hsa049771.37208090
34GnRH signaling pathway_Homo sapiens_hsa049121.37117199
35* Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30171274
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.28100029
37cAMP signaling pathway_Homo sapiens_hsa040241.27463079
38Bile secretion_Homo sapiens_hsa049761.22749579
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22452306
40ABC transporters_Homo sapiens_hsa020101.22290136
41Type II diabetes mellitus_Homo sapiens_hsa049301.21528119
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.18039520
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10125337
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08568518
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05093054
46Arginine biosynthesis_Homo sapiens_hsa002201.03819512
47Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03131212
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02578016
49Pancreatic secretion_Homo sapiens_hsa049721.02559021
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.98260919
51Insulin resistance_Homo sapiens_hsa049310.96961683
52Gap junction_Homo sapiens_hsa045400.95372549
53Retinol metabolism_Homo sapiens_hsa008300.95357262
54Arginine and proline metabolism_Homo sapiens_hsa003300.94928059
55Estrogen signaling pathway_Homo sapiens_hsa049150.93284887
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93172249
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.89998914
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89911715
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88841979
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87213471
61Cardiac muscle contraction_Homo sapiens_hsa042600.87187543
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.87024505
63Collecting duct acid secretion_Homo sapiens_hsa049660.86188362
64Renal cell carcinoma_Homo sapiens_hsa052110.85700028
65Glioma_Homo sapiens_hsa052140.84992210
66Insulin signaling pathway_Homo sapiens_hsa049100.81565246
67Tight junction_Homo sapiens_hsa045300.81452082
68Thyroid hormone synthesis_Homo sapiens_hsa049180.79535434
69Dilated cardiomyopathy_Homo sapiens_hsa054140.79311294
70Melanogenesis_Homo sapiens_hsa049160.77216956
71Chemical carcinogenesis_Homo sapiens_hsa052040.76316442
72Phototransduction_Homo sapiens_hsa047440.76276020
73Axon guidance_Homo sapiens_hsa043600.75537497
74Phenylalanine metabolism_Homo sapiens_hsa003600.74782233
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74509285
76Adherens junction_Homo sapiens_hsa045200.73593289
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72155650
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.71341389
79Choline metabolism in cancer_Homo sapiens_hsa052310.71276040
80Glucagon signaling pathway_Homo sapiens_hsa049220.71151358
81Butanoate metabolism_Homo sapiens_hsa006500.71107646
82ErbB signaling pathway_Homo sapiens_hsa040120.68654210
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.68637836
84FoxO signaling pathway_Homo sapiens_hsa040680.68589101
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.67808581
86Circadian rhythm_Homo sapiens_hsa047100.67729511
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65845847
88Mineral absorption_Homo sapiens_hsa049780.65183655
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65047976
90Endometrial cancer_Homo sapiens_hsa052130.64379793
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61364898
92Linoleic acid metabolism_Homo sapiens_hsa005910.60418081
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.59542247
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58402998
95Dorso-ventral axis formation_Homo sapiens_hsa043200.57536916
96Vibrio cholerae infection_Homo sapiens_hsa051100.56387151
97Glycerolipid metabolism_Homo sapiens_hsa005610.56257284
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55953170
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.53690159
100AMPK signaling pathway_Homo sapiens_hsa041520.50470598
101African trypanosomiasis_Homo sapiens_hsa051430.50247323
102Galactose metabolism_Homo sapiens_hsa000520.49458940
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48367992
104Thyroid cancer_Homo sapiens_hsa052160.46696541
105Inositol phosphate metabolism_Homo sapiens_hsa005620.45248134
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44606592
107VEGF signaling pathway_Homo sapiens_hsa043700.43956702
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43763582
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43592885
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.42366353
111Prion diseases_Homo sapiens_hsa050200.41674771
112Rap1 signaling pathway_Homo sapiens_hsa040150.40988607
113MAPK signaling pathway_Homo sapiens_hsa040100.40759052
114Focal adhesion_Homo sapiens_hsa045100.40637844
115PPAR signaling pathway_Homo sapiens_hsa033200.39220267
116Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37104983
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36961422
118Ras signaling pathway_Homo sapiens_hsa040140.36336893
119Propanoate metabolism_Homo sapiens_hsa006400.36287068
120Fat digestion and absorption_Homo sapiens_hsa049750.34304275
121Fatty acid degradation_Homo sapiens_hsa000710.32706964
122Fatty acid biosynthesis_Homo sapiens_hsa000610.32695028
123Alzheimers disease_Homo sapiens_hsa050100.32675630
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.32650314
125Ovarian steroidogenesis_Homo sapiens_hsa049130.32570014
126Pyruvate metabolism_Homo sapiens_hsa006200.32248429
127Sulfur metabolism_Homo sapiens_hsa009200.31719709
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30610887
129Starch and sucrose metabolism_Homo sapiens_hsa005000.29298475
130Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29262591
131Tryptophan metabolism_Homo sapiens_hsa003800.27858443
132Fatty acid metabolism_Homo sapiens_hsa012120.25710824
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25496735
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24823967

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