NR4A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gamma-delta T cell differentiation (GO:0045586)9.28695638
2regulation of gamma-delta T cell activation (GO:0046643)8.40734123
3* endothelial cell chemotaxis (GO:0035767)7.12315388
4regulation of interleukin-12 biosynthetic process (GO:0045075)6.59663207
5positive thymic T cell selection (GO:0045059)6.40432439
6atrioventricular valve morphogenesis (GO:0003181)6.14062737
7positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.57934603
8positive T cell selection (GO:0043368)5.53789507
9NIK/NF-kappaB signaling (GO:0038061)5.50549965
10positive regulation of gamma-delta T cell activation (GO:0046645)5.40560027
11thymic T cell selection (GO:0045061)5.33623853
12cellular response to gonadotropin stimulus (GO:0071371)5.12610624
13negative thymic T cell selection (GO:0045060)4.94588407
14interferon-gamma production (GO:0032609)4.89492334
15negative T cell selection (GO:0043383)4.88836021
16positive regulation of T cell differentiation in thymus (GO:0033089)4.80399723
17T cell selection (GO:0045058)4.76738993
18tolerance induction (GO:0002507)4.57040939
19response to interleukin-15 (GO:0070672)4.55993679
20negative regulation of T cell differentiation in thymus (GO:0033085)4.46014577
21JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)4.39965634
22regulation of regulatory T cell differentiation (GO:0045589)4.25825896
23myeloid dendritic cell differentiation (GO:0043011)4.08368892
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.05970204
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.05970204
26positive regulation of interleukin-2 production (GO:0032743)3.96270414
27positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.96216267
28* cell migration involved in sprouting angiogenesis (GO:0002042)3.93796944
29surfactant homeostasis (GO:0043129)3.91796135
30regulation of isotype switching to IgG isotypes (GO:0048302)3.89778218
31regulation of T cell differentiation in thymus (GO:0033081)3.86550531
32response to muramyl dipeptide (GO:0032495)3.86155284
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.83578895
34cellular response to interleukin-15 (GO:0071350)3.82715999
35negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.78844694
36regulation of interleukin-2 biosynthetic process (GO:0045076)3.78803119
37T cell receptor signaling pathway (GO:0050852)3.76948344
38regulation of T cell tolerance induction (GO:0002664)3.75960512
39CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.75952719
40response to gonadotropin (GO:0034698)3.68378902
41myeloid dendritic cell activation (GO:0001773)3.67822997
42regulation of thymocyte apoptotic process (GO:0070243)3.66205422
43antigen processing and presentation of endogenous antigen (GO:0019883)3.65033816
44negative regulation of erythrocyte differentiation (GO:0045647)3.62199581
45positive regulation of T cell apoptotic process (GO:0070234)3.56068042
46negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.54619344
47negative regulation of cell killing (GO:0031342)3.54619344
48peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.52077863
49T cell migration (GO:0072678)3.51177516
50fibroblast migration (GO:0010761)3.47571392
51regulation of p38MAPK cascade (GO:1900744)3.46493360
52regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.44959572
53chemical homeostasis within a tissue (GO:0048875)3.42514596
54leukocyte aggregation (GO:0070486)3.38290115
55regulation of response to interferon-gamma (GO:0060330)3.37087847
56tyrosine phosphorylation of STAT protein (GO:0007260)3.34582082
57alpha-beta T cell differentiation (GO:0046632)3.33366248
58regulation of cell proliferation involved in kidney development (GO:1901722)3.24644030
59positive regulation of mRNA catabolic process (GO:0061014)3.21713353
60positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.19978692
61regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.19978692
62negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.18646928
63heart valve morphogenesis (GO:0003179)3.17525999
64T cell differentiation (GO:0030217)3.16809888
65positive regulation of tolerance induction (GO:0002645)3.16018645
66positive regulation of isotype switching (GO:0045830)3.14818820
67regulation of immunoglobulin secretion (GO:0051023)3.13544934
68interleukin-1-mediated signaling pathway (GO:0070498)3.13334458
69T-helper cell differentiation (GO:0042093)3.11859973
70CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.11859973
71positive regulation of metanephros development (GO:0072216)3.10650464
72positive regulation of astrocyte differentiation (GO:0048711)3.10185762
73embryonic process involved in female pregnancy (GO:0060136)3.10152699
74alpha-beta T cell activation (GO:0046631)3.09253141
75regulation of T cell differentiation (GO:0045580)3.08724699
76* cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.08587166
77extracellular matrix assembly (GO:0085029)3.06906938
78positive regulation of T cell differentiation (GO:0045582)3.06212754
79regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.02999799
80SMAD protein signal transduction (GO:0060395)3.02563928
81antigen receptor-mediated signaling pathway (GO:0050851)2.98512282
82response to corticosterone (GO:0051412)2.95386177
83T cell costimulation (GO:0031295)2.94300220
84regulation of interleukin-2 production (GO:0032663)2.92880830
85cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.92798684
86response to isoquinoline alkaloid (GO:0014072)2.92743049
87entrainment of circadian clock by photoperiod (GO:0043153)2.92542847
88endoderm formation (GO:0001706)2.90543411
89response to progesterone (GO:0032570)2.89549675
90regulation of mRNA catabolic process (GO:0061013)2.88218154
91lymphocyte costimulation (GO:0031294)2.87752159
92positive regulation of lymphocyte apoptotic process (GO:0070230)2.86989014
93* blood vessel endothelial cell migration (GO:0043534)2.86583975
94regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.84085066
95cellular response to nicotine (GO:0071316)2.82008598
96positive regulation of osteoblast proliferation (GO:0033690)2.81284521
97regulation of interleukin-13 production (GO:0032656)2.80701944
98oxygen transport (GO:0015671)2.80509153
99germinal center formation (GO:0002467)2.80375301
100lung lobe morphogenesis (GO:0060463)2.80068166
101endocardial cushion morphogenesis (GO:0003203)2.79377939
102regulation of triglyceride biosynthetic process (GO:0010866)2.78891803
103alpha-beta T cell differentiation involved in immune response (GO:0002293)2.76409891
104alpha-beta T cell activation involved in immune response (GO:0002287)2.76409891
105T cell differentiation involved in immune response (GO:0002292)2.76409891
106positive regulation of humoral immune response (GO:0002922)2.76233557
107regulation of B cell receptor signaling pathway (GO:0050855)2.74852543
108regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.73489917
109positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.73489917
110cellular extravasation (GO:0045123)2.73014652
111response to laminar fluid shear stress (GO:0034616)2.72848575
112regulation of tolerance induction (GO:0002643)2.72721952
113regulation of alpha-beta T cell proliferation (GO:0046640)2.71633465
114positive regulation of p38MAPK cascade (GO:1900745)2.70815307
115angiogenesis involved in wound healing (GO:0060055)2.70424264
116epithelial cell-cell adhesion (GO:0090136)2.63574328
117lung vasculature development (GO:0060426)2.62557937
118cell proliferation involved in kidney development (GO:0072111)2.62017715
119response to follicle-stimulating hormone (GO:0032354)2.61358802
120positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.59441427
121regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.59409846
122heart valve formation (GO:0003188)2.58176484
123regulation of monocyte differentiation (GO:0045655)2.57017254
124cell volume homeostasis (GO:0006884)2.54481074
125negative regulation of cAMP-mediated signaling (GO:0043951)2.53126740
126negative regulation of actin filament bundle assembly (GO:0032232)2.53034833
127cellular response to epinephrine stimulus (GO:0071872)2.52981463
128mRNA transcription from RNA polymerase II promoter (GO:0042789)2.52681302
129negative regulation of gluconeogenesis (GO:0045721)2.52459370
130negative regulation of inclusion body assembly (GO:0090084)2.50506410
131atrial septum morphogenesis (GO:0060413)2.49262720
132activation of MAPKKK activity (GO:0000185)2.49251988
133mannose metabolic process (GO:0006013)2.48425566
134positive regulation of odontogenesis (GO:0042482)2.46447570
135negative regulation of fatty acid transport (GO:2000192)2.46387365
136* skeletal muscle cell differentiation (GO:0035914)2.46333496
137establishment of endothelial barrier (GO:0061028)2.45699605
138glomerular basement membrane development (GO:0032836)2.45403267
139cellular response to antibiotic (GO:0071236)2.45125475
140mRNA transcription (GO:0009299)2.44738134
141response to fluid shear stress (GO:0034405)2.44444856
142positive regulation of triglyceride biosynthetic process (GO:0010867)2.42110664
143cell-cell junction maintenance (GO:0045217)2.40697522
144positive regulation of extracellular matrix organization (GO:1903055)2.39028284
145cellular response to fluid shear stress (GO:0071498)2.37442107
146response to mineralocorticoid (GO:0051385)2.37224872
147smooth muscle tissue development (GO:0048745)2.34604434
148positive regulation of glomerulus development (GO:0090193)2.33995799
149positive regulation of histone deacetylation (GO:0031065)2.33960357
150negative regulation of complement activation (GO:0045916)2.33530536
151ovulation from ovarian follicle (GO:0001542)2.31377191
152regulation of transforming growth factor beta1 production (GO:0032908)2.29854387
153mesenchyme morphogenesis (GO:0072132)2.29820002
154positive regulation of CREB transcription factor activity (GO:0032793)2.29339875
155positive regulation of protein kinase C signaling (GO:0090037)2.27915189
156regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.27191541
157endocrine hormone secretion (GO:0060986)2.26661982
158Notch signaling involved in heart development (GO:0061314)2.25676435
159placenta blood vessel development (GO:0060674)2.23895500
160vascular endothelial growth factor signaling pathway (GO:0038084)2.22520769
161photoperiodism (GO:0009648)2.21148607
162response to cAMP (GO:0051591)2.20380465
163outflow tract morphogenesis (GO:0003151)2.18558344
164entrainment of circadian clock (GO:0009649)2.18505536
165cardiac myofibril assembly (GO:0055003)2.18504270
166ventricular septum morphogenesis (GO:0060412)2.18426417
167response to epinephrine (GO:0071871)2.17543693
168facial nerve structural organization (GO:0021612)2.16815779
169cellular response to cAMP (GO:0071320)2.16635005
170glomerular filtration (GO:0003094)2.16547376
171negative regulation of stress fiber assembly (GO:0051497)2.15533557
172positive regulation by host of viral transcription (GO:0043923)2.14703706
173regulation of gonadotropin secretion (GO:0032276)2.12696232

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.29260958
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.08496250
3EGR1_19374776_ChIP-ChIP_THP-1_Human5.32249527
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.57672161
5NOTCH1_21737748_ChIP-Seq_TLL_Human3.99492723
6MYC_22102868_ChIP-Seq_BL_Human3.84488272
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.60187632
8* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.32815896
9RUNX_20019798_ChIP-Seq_JUKART_Human3.30845067
10* TCF7_22412390_ChIP-Seq_EML_Mouse2.81976159
11* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.79514308
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.62616620
13MAF_26560356_Chip-Seq_TH1_Human2.53021884
14MYB_26560356_Chip-Seq_TH2_Human2.52235667
15* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.51685387
16* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.51275801
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.49426934
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.42808333
19* KDM2B_26808549_Chip-Seq_DND41_Human2.37281970
20* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.31722394
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.20423598
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.17793845
23IRF8_22096565_ChIP-ChIP_GC-B_Human2.16090121
24MYB_26560356_Chip-Seq_TH1_Human2.12544894
25* CLOCK_20551151_ChIP-Seq_293T_Human2.11534758
26RARG_19884340_ChIP-ChIP_MEFs_Mouse2.10744397
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.07992656
28* UTX_26944678_Chip-Seq_JUKART_Human2.01542805
29KDM2B_26808549_Chip-Seq_JURKAT_Human1.98751444
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.98034545
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.97495565
32VDR_21846776_ChIP-Seq_THP-1_Human1.97039531
33SCL_19346495_ChIP-Seq_HPC-7_Human1.94012073
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92685651
35* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.89579946
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.89161501
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.88008499
38DROSHA_22980978_ChIP-Seq_HELA_Human1.83976499
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.80267621
40* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77650634
41VDR_24763502_ChIP-Seq_THP-1_Human1.72836348
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70727701
43NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.70324924
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.63704707
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.62867017
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.61501549
47FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.61217326
48* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58583368
49MAF_26560356_Chip-Seq_TH2_Human1.54676501
50ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.54408170
51GATA3_27048872_Chip-Seq_THYMUS_Human1.42751224
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.42395349
53ZNF263_19887448_ChIP-Seq_K562_Human1.41771860
54FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.41203370
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.40563605
56IRF8_27001747_Chip-Seq_BMDM_Mouse1.36230289
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35622957
58AHR_22903824_ChIP-Seq_MCF-7_Human1.34971700
59SOX9_24532713_ChIP-Seq_HFSC_Mouse1.34088005
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32914955
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32254269
62SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.32201682
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.31844893
64* KDM2B_26808549_Chip-Seq_K562_Human1.30677508
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.30110783
66RUNX1_27514584_Chip-Seq_MCF-7_Human1.29009921
67TBX20_22328084_ChIP-Seq_HEART_Mouse1.28384490
68TBX20_22080862_ChIP-Seq_HEART_Mouse1.28384490
69* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.27176834
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26672311
71NCOR1_26117541_ChIP-Seq_K562_Human1.26467257
72* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22675100
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22232898
74LXR_22158963_ChIP-Seq_LIVER_Mouse1.22031055
75EZH2_18974828_ChIP-Seq_MESCs_Mouse1.21504245
76RNF2_18974828_ChIP-Seq_MESCs_Mouse1.21504245
77RNF2_27304074_Chip-Seq_ESCs_Mouse1.21202026
78TP63_17297297_ChIP-ChIP_HaCaT_Human1.20754634
79CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17847996
80MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17498866
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17253834
82RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.17150660
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14543970
84FOXO3_23340844_ChIP-Seq_DLD1_Human1.14506190
85* RACK7_27058665_Chip-Seq_MCF-7_Human1.14283673
86EZH2_27294783_Chip-Seq_ESCs_Mouse1.13931473
87IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13297079
88ATF3_27146783_Chip-Seq_COLON_Human1.12014051
89ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11584588
90BP1_19119308_ChIP-ChIP_Hs578T_Human1.11257437
91WT1_19549856_ChIP-ChIP_CCG9911_Human1.11211693
92RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10935339
93UBF1/2_26484160_Chip-Seq_HMECs_Human1.10633661
94SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10240856
95SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09251948
96SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08544054
97* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08531049
98GATA1_19941826_ChIP-Seq_K562_Human1.08183766
99EED_16625203_ChIP-ChIP_MESCs_Mouse1.08004587
100SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07984894
101* RING1B_27294783_Chip-Seq_NPCs_Mouse1.07214457
102* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07015523
103* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07004535
104* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04150563
105EP300_21415370_ChIP-Seq_HL-1_Mouse1.03993278
106WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03864585
107* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02402872
108SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00438524
109ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00048282
110PPARA_22158963_ChIP-Seq_LIVER_Mouse0.99946977
111SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99421622
112ARNT_22903824_ChIP-Seq_MCF-7_Human0.99270363
113CTCF_27219007_Chip-Seq_Bcells_Human0.98697091
114CREB1_26743006_Chip-Seq_LNCaP_Human0.98246601
115SPI1_23127762_ChIP-Seq_K562_Human0.97591859
116SMC4_20622854_ChIP-Seq_HELA_Human0.96741537
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96198712
118NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96073826
119AR_21572438_ChIP-Seq_LNCaP_Human0.95622524
120KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.94557728
121KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.94557728
122KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.94557728
123RXR_22158963_ChIP-Seq_LIVER_Mouse0.94133090
124* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94123681
125EGR1_19032775_ChIP-ChIP_M12_Human0.92764885
126NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91160592
127SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.90842764
128RING1B_27294783_Chip-Seq_ESCs_Mouse0.90602563
129LXR_22292898_ChIP-Seq_THP-1_Human0.90159965
130SMC3_22415368_ChIP-Seq_MEFs_Mouse0.89858874
131* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86790801
132JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86284766
133MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.85884364
134SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85567588
135SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85567588
136VDR_24787735_ChIP-Seq_THP-1_Human0.85105664
137GATA2_21666600_ChIP-Seq_HMVEC_Human0.84648782
138ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.84646073
139SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.84255973
140SMAD_19615063_ChIP-ChIP_OVARY_Human0.84215282
141ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84018880
142TRIM28_21343339_ChIP-Seq_HEK293_Human0.83537247
143GATA2_19941826_ChIP-Seq_K562_Human0.82923115
144SMC1_22415368_ChIP-Seq_MEFs_Mouse0.82629358
145TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82523855
146PU_27001747_Chip-Seq_BMDM_Mouse0.81815494
147NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.80878899
148TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.80283827
149* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.78258831
150GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77637882
151TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.77568107
152GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77097511

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004510_myositis4.82832417
2MP0003763_abnormal_thymus_physiology4.73737243
3MP0005423_abnormal_somatic_nervous3.91275997
4MP0003303_peritoneal_inflammation3.53792976
5MP0000685_abnormal_immune_system3.52014745
6MP0003436_decreased_susceptibility_to3.24386916
7MP0001853_heart_inflammation3.07314752
8MP0003300_gastrointestinal_ulcer3.01817739
9MP0008961_abnormal_basal_metabolism2.82353227
10MP0003724_increased_susceptibility_to2.75413261
11MP0005387_immune_system_phenotype2.69608399
12MP0001790_abnormal_immune_system2.69608399
13MP0002405_respiratory_system_inflammati2.67049561
14MP0008004_abnormal_stomach_pH2.66446902
15MP0005000_abnormal_immune_tolerance2.64322434
16MP0002138_abnormal_hepatobiliary_system2.63927533
17MP0001800_abnormal_humoral_immune2.59090349
18MP0005671_abnormal_response_to2.48858696
19MP0001958_emphysema2.45744793
20MP0009840_abnormal_foam_cell2.41892337
21MP0006138_congestive_heart_failure2.41695342
22MP0002723_abnormal_immune_serum2.30768039
23MP0004947_skin_inflammation2.27419221
24MP0005670_abnormal_white_adipose2.27071817
25MP0005083_abnormal_biliary_tract2.24477393
26MP0003866_abnormal_defecation2.23566965
27MP0002452_abnormal_antigen_presenting2.18256886
28MP0000013_abnormal_adipose_tissue2.17820140
29MP0005503_abnormal_tendon_morphology2.15977823
30MP0002420_abnormal_adaptive_immunity2.11734599
31MP0010155_abnormal_intestine_physiology2.11579372
32MP0002166_altered_tumor_susceptibility2.11281694
33MP0000767_abnormal_smooth_muscle2.08445577
34MP0001819_abnormal_immune_cell2.08420732
35MP0001835_abnormal_antigen_presentation2.06516725
36MP0001851_eye_inflammation2.05911521
37* MP0002398_abnormal_bone_marrow2.02570185
38MP0009384_cardiac_valve_regurgitation2.01817936
39MP0009278_abnormal_bone_marrow1.96024938
40* MP0000703_abnormal_thymus_morphology1.95980795
41MP0001873_stomach_inflammation1.84688361
42MP0004782_abnormal_surfactant_physiolog1.81243204
43* MP0004808_abnormal_hematopoietic_stem1.79950544
44* MP0000716_abnormal_immune_system1.74613716
45MP0001533_abnormal_skeleton_physiology1.63938658
46MP0002108_abnormal_muscle_morphology1.61373370
47MP0005409_darkened_coat_color1.60694562
48MP0002933_joint_inflammation1.59637676
49* MP0002722_abnormal_immune_system1.58431447
50MP0003283_abnormal_digestive_organ1.58240474
51MP0002419_abnormal_innate_immunity1.56554606
52MP0008995_early_reproductive_senescence1.55554220
53MP0000465_gastrointestinal_hemorrhage1.55362169
54* MP0000689_abnormal_spleen_morphology1.54817393
55MP0005025_abnormal_response_to1.54415648
56MP0002998_abnormal_bone_remodeling1.52959571
57MP0002006_tumorigenesis1.52249198
58MP0004742_abnormal_vestibular_system1.51886292
59MP0004084_abnormal_cardiac_muscle1.48966721
60MP0003705_abnormal_hypodermis_morpholog1.48929171
61MP0001845_abnormal_inflammatory_respons1.48520801
62MP0002396_abnormal_hematopoietic_system1.48246805
63MP0009785_altered_susceptibility_to1.46255121
64MP0009333_abnormal_splenocyte_physiolog1.44885697
65MP0005330_cardiomyopathy1.38369104
66MP0000003_abnormal_adipose_tissue1.38325137
67* MP0002429_abnormal_blood_cell1.37502044
68MP0005310_abnormal_salivary_gland1.35813507
69MP0002148_abnormal_hypersensitivity_rea1.34806553
70MP0005275_abnormal_skin_tensile1.34100990
71MP0005167_abnormal_blood-brain_barrier1.31528799
72MP0002896_abnormal_bone_mineralization1.30061379
73MP0005076_abnormal_cell_differentiation1.27787534
74MP0010352_gastrointestinal_tract_polyps1.27771027
75MP0005164_abnormal_response_to1.24805347
76MP0000751_myopathy1.23663786
77MP0001542_abnormal_bone_strength1.23526294
78MP0004036_abnormal_muscle_relaxation1.22334044
79MP0001501_abnormal_sleep_pattern1.22230216
80MP0005397_hematopoietic_system_phenotyp1.21061895
81MP0001545_abnormal_hematopoietic_system1.21061895
82MP0005375_adipose_tissue_phenotype1.20036283
83MP0004043_abnormal_pH_regulation1.18536261
84MP0003828_pulmonary_edema1.15375540
85MP0005058_abnormal_lysosome_morphology1.12291561
86MP0005390_skeleton_phenotype1.10913972
87MP0005595_abnormal_vascular_smooth1.10568889
88MP0006082_CNS_inflammation1.09652740
89MP0005508_abnormal_skeleton_morphology1.08565701
90MP0002249_abnormal_larynx_morphology1.08180942
91MP0005464_abnormal_platelet_physiology1.07302958
92MP0008438_abnormal_cutaneous_collagen1.05081570
93MP0000604_amyloidosis1.04223239
94MP0005023_abnormal_wound_healing1.02192217
95MP0010630_abnormal_cardiac_muscle1.00853731
96MP0003795_abnormal_bone_structure1.00327550
97MP0003879_abnormal_hair_cell0.99445024
98MP0001756_abnormal_urination0.98056930
99MP0002009_preneoplasia0.97615223
100MP0001348_abnormal_lacrimal_gland0.96344734
101MP0009115_abnormal_fat_cell0.95194402
102MP0004087_abnormal_muscle_fiber0.94407157
103MP0002877_abnormal_melanocyte_morpholog0.93902435
104MP0003045_fibrosis0.92960852
105MP0002254_reproductive_system_inflammat0.92217107
106MP0005620_abnormal_muscle_contractility0.91182100
107MP0005646_abnormal_pituitary_gland0.90786768
108MP0002127_abnormal_cardiovascular_syste0.89931854
109MP0001614_abnormal_blood_vessel0.89292405
110MP0002925_abnormal_cardiovascular_devel0.89023797
111MP0003075_altered_response_to0.88835941
112MP0002972_abnormal_cardiac_muscle0.88268726
113MP0003448_altered_tumor_morphology0.87063606
114MP0002128_abnormal_blood_circulation0.87059306
115MP0000249_abnormal_blood_vessel0.86625110
116MP0003453_abnormal_keratinocyte_physiol0.85870843
117MP0005666_abnormal_adipose_tissue0.84869179
118MP0003091_abnormal_cell_migration0.84642954
119MP0001270_distended_abdomen0.84432341
120MP0000230_abnormal_systemic_arterial0.82569001
121MP0005448_abnormal_energy_balance0.82067687
122MP0004883_abnormal_blood_vessel0.80744978
123MP0004233_abnormal_muscle_weight0.79584945
124MP0002332_abnormal_exercise_endurance0.79106449
125MP0005166_decreased_susceptibility_to0.78244936
126MP0002168_other_aberrant_phenotype0.77672195
127MP0001243_abnormal_dermal_layer0.76568348
128MP0010307_abnormal_tumor_latency0.76458600
129MP0000858_altered_metastatic_potential0.76110436
130MP0004085_abnormal_heartbeat0.75451453
131MP0004484_altered_response_of0.74709964
132MP0003959_abnormal_lean_body0.73770080
133MP0002089_abnormal_postnatal_growth/wei0.73479145
134MP0001727_abnormal_embryo_implantation0.72365527
135MP0003279_aneurysm0.71916109
136MP0002133_abnormal_respiratory_system0.70772865
137MP0005388_respiratory_system_phenotype0.70772865
138MP0010368_abnormal_lymphatic_system0.70310068
139MP0000759_abnormal_skeletal_muscle0.69972473
140MP0005334_abnormal_fat_pad0.69785877
141MP0002295_abnormal_pulmonary_circulatio0.69326389
142MP0000609_abnormal_liver_physiology0.69283721
143MP0001664_abnormal_digestion0.68926104
144MP0002277_abnormal_respiratory_mucosa0.65375547
145MP0001881_abnormal_mammary_gland0.64916841
146MP0001502_abnormal_circadian_rhythm0.63546092
147MP0005165_increased_susceptibility_to0.62989481
148MP0000490_abnormal_crypts_of0.61426926
149MP0008469_abnormal_protein_level0.61206573
150MP0002928_abnormal_bile_duct0.60507595
151MP0003329_amyloid_beta_deposits0.57049130
152MP0001216_abnormal_epidermal_layer0.55611358
153MP0003566_abnormal_cell_adhesion0.55418078
154MP0008007_abnormal_cellular_replicative0.54754594
155MP0003943_abnormal_hepatobiliary_system0.53643386
156MP0001191_abnormal_skin_condition0.53343266
157MP0002060_abnormal_skin_morphology0.52972977
158MP0000733_abnormal_muscle_development0.52968764
159MP0001879_abnormal_lymphatic_vessel0.52602891
160MP0001340_abnormal_eyelid_morphology0.52054657

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)8.09330643
2Increased density of long bones (HP:0006392)5.30655479
3Obstructive sleep apnea (HP:0002870)5.25863394
4Elevated erythrocyte sedimentation rate (HP:0003565)5.00623932
5Persistence of primary teeth (HP:0006335)4.72667703
6Peripheral hypomyelination (HP:0007182)4.66554085
7Broad face (HP:0000283)4.16467394
8Eczematoid dermatitis (HP:0000976)3.96261504
9Ulnar claw (HP:0001178)3.86852200
10Upper limb muscle weakness (HP:0003484)3.75707688
11Segmental peripheral demyelination/remyelination (HP:0003481)3.72728459
12IgM deficiency (HP:0002850)3.63520265
13T lymphocytopenia (HP:0005403)3.63330724
14Severe combined immunodeficiency (HP:0004430)3.56110707
15Bronchomalacia (HP:0002780)3.52795067
16Abnormality of T cell number (HP:0011839)3.52330360
17Increased IgM level (HP:0003496)3.50477153
18Abnormality of the nasal mucosa (HP:0000433)3.43621716
19Panhypogammaglobulinemia (HP:0003139)3.41734899
20Nasal polyposis (HP:0100582)3.41583486
21Myositis (HP:0100614)3.36743144
22Abnormality of T cells (HP:0002843)3.31670454
23Recurrent fungal infections (HP:0002841)3.31654005
24Aortic aneurysm (HP:0004942)3.29887194
25Abnormality of the fingertips (HP:0001211)3.29497462
26Cerebral aneurysm (HP:0004944)3.18127269
27IgG deficiency (HP:0004315)3.14636431
28Recurrent bronchitis (HP:0002837)3.14318529
29Spontaneous hematomas (HP:0007420)3.08414421
30Impaired proprioception (HP:0010831)3.06109528
31Combined immunodeficiency (HP:0005387)3.00893798
32Shallow orbits (HP:0000586)2.99077898
33Orchitis (HP:0100796)2.98962502
34Muscle fiber splitting (HP:0003555)2.96761704
35Abnormal delayed hypersensitivity skin test (HP:0002963)2.96551382
36Abnormality of T cell physiology (HP:0011840)2.95285005
37Abnormality of B cell number (HP:0010975)2.91834815
38B lymphocytopenia (HP:0010976)2.91834815
39IgA deficiency (HP:0002720)2.91824966
40Somatic mutation (HP:0001428)2.90320683
41Chronic otitis media (HP:0000389)2.90198924
42Optic neuritis (HP:0100653)2.79900146
43Retrobulbar optic neuritis (HP:0100654)2.79900146
44Increased CSF protein (HP:0002922)2.76454646
45Arterial thrombosis (HP:0004420)2.76131723
46Pulmonary infiltrates (HP:0002113)2.74433895
47Arterial tortuosity (HP:0005116)2.71598654
48Increased connective tissue (HP:0009025)2.69031169
49Abnormality of eosinophils (HP:0001879)2.67370904
50Gastrointestinal infarctions (HP:0005244)2.61373337
51Aortic regurgitation (HP:0001659)2.57523973
52Neoplasm of the heart (HP:0100544)2.56770472
53Laryngomalacia (HP:0001601)2.56092173
54Vasculitis (HP:0002633)2.54612352
55Mitral valve prolapse (HP:0001634)2.54306405
56Leukocytosis (HP:0001974)2.51948425
57Chronic diarrhea (HP:0002028)2.51450525
58Vascular tortuosity (HP:0004948)2.50479485
59Chest pain (HP:0100749)2.45133702
60Emphysema (HP:0002097)2.44606737
61Mediastinal lymphadenopathy (HP:0100721)2.43807735
62Aortic dissection (HP:0002647)2.43441588
63Increased IgE level (HP:0003212)2.42978654
64Lymphangioma (HP:0100764)2.41651105
65Depressed nasal tip (HP:0000437)2.39077248
66Recurrent viral infections (HP:0004429)2.38614409
67Disproportionate tall stature (HP:0001519)2.37935096
68Interstitial pulmonary disease (HP:0006530)2.37417596
69Abnormality of the distal phalanx of the thumb (HP:0009617)2.33895086
70Lymphopenia (HP:0001888)2.32976624
71Abnormality of the aortic arch (HP:0012303)2.32611382
72Eosinophilia (HP:0001880)2.32066030
73Malnutrition (HP:0004395)2.29987772
74Asymmetric septal hypertrophy (HP:0001670)2.29883762
75Gastrointestinal stroma tumor (HP:0100723)2.28562406
76Joint stiffness (HP:0001387)2.27830684
77Pustule (HP:0200039)2.27794686
78Hemoptysis (HP:0002105)2.23663894
79Abnormality of cells of the lymphoid lineage (HP:0012140)2.22587089
80Distal lower limb muscle weakness (HP:0009053)2.22476223
81Thrombocytosis (HP:0001894)2.20439107
82Genetic anticipation (HP:0003743)2.19176537
83Nuclear cataract (HP:0100018)2.18977178
84Fatigue (HP:0012378)2.18079204
85Striae distensae (HP:0001065)2.15745776
86Thyroiditis (HP:0100646)2.14080066
87Hematochezia (HP:0002573)2.13730508
88Dilatation of the ascending aorta (HP:0005111)2.13059631
89Stridor (HP:0010307)2.11637842
90Cervical subluxation (HP:0003308)2.11368340
91Decreased circulating renin level (HP:0003351)2.08782112
92Sleep apnea (HP:0010535)2.08365440
93Broad metatarsal (HP:0001783)2.08259798
94Bicuspid aortic valve (HP:0001647)2.07693975
95J-shaped sella turcica (HP:0002680)2.07322904
96Pulmonary artery stenosis (HP:0004415)2.06539315
97Stomach cancer (HP:0012126)2.06244429
98Chronic mucocutaneous candidiasis (HP:0002728)2.05142809
99Recurrent cutaneous fungal infections (HP:0011370)2.05142809
100Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.04453625
101Hepatitis (HP:0012115)2.04418279
102Polycythemia (HP:0001901)2.04372897
103Myocardial infarction (HP:0001658)2.02298557
104Clumsiness (HP:0002312)2.01692867
105Distal lower limb amyotrophy (HP:0008944)2.01480234
106Lymphoma (HP:0002665)2.00930084
107Keratoconjunctivitis sicca (HP:0001097)1.99970716
108Hypergammaglobulinemia (HP:0010702)1.99210782
109Stroke (HP:0001297)1.97650328
110Amaurosis fugax (HP:0100576)1.97481849
111Abnormality of the nasal septum (HP:0000419)1.95657380
112Accelerated skeletal maturation (HP:0005616)1.95225073
113Sparse lateral eyebrow (HP:0005338)1.93986434
114Pulmonary embolism (HP:0002204)1.91600469
115Protrusio acetabuli (HP:0003179)1.91216598
116Tracheomalacia (HP:0002779)1.89978182
117Inflammation of the large intestine (HP:0002037)1.89904024
118Spondylolisthesis (HP:0003302)1.87086339
119Complement deficiency (HP:0004431)1.86849837
120Aplasia of the musculature (HP:0100854)1.85548196
121Short hallux (HP:0010109)1.85324730
122Epistaxis (HP:0000421)1.85290445
123Dislocated radial head (HP:0003083)1.84945118
124Prolonged QT interval (HP:0001657)1.84560041
125Joint swelling (HP:0001386)1.84135760
126Long eyelashes (HP:0000527)1.83387375
127Spinal canal stenosis (HP:0003416)1.81937903
128Cellulitis (HP:0100658)1.81566840
129Germ cell neoplasia (HP:0100728)1.80963793
130Onion bulb formation (HP:0003383)1.80949217
131Gingivitis (HP:0000230)1.80474727
132Dysmetric saccades (HP:0000641)1.79121635
133Mitral regurgitation (HP:0001653)1.78981395
134Mucopolysacchariduria (HP:0008155)1.78083797
135Urinary glycosaminoglycan excretion (HP:0003541)1.78083797
136Long palpebral fissure (HP:0000637)1.78073671
137Abnormality of polysaccharide metabolism (HP:0011012)1.76860575
138Abnormality of glycosaminoglycan metabolism (HP:0004371)1.76860575
139Abnormality of mucopolysaccharide metabolism (HP:0011020)1.76860575
140Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.76007427
141Aneurysm (HP:0002617)1.76004980
142Flared iliac wings (HP:0002869)1.75957922
143Prolonged bleeding time (HP:0003010)1.75468111
144Aortic valve stenosis (HP:0001650)1.75316201
145Gastrointestinal inflammation (HP:0004386)1.75168354
146Thin ribs (HP:0000883)1.75163500
147Overgrowth (HP:0001548)1.74554745
148Difficulty climbing stairs (HP:0003551)1.74498482
149Keratoconjunctivitis (HP:0001096)1.74006857
150Abnormality of the radial head (HP:0003995)1.73710475
151Abnormality of the humeroradial joint (HP:0100744)1.73527893
152Bone cyst (HP:0012062)1.72880311
153Granulocytopenia (HP:0001913)1.72796438
154Ulnar deviation of the wrist (HP:0003049)1.72754359
155Papilledema (HP:0001085)1.71051540
156Bronchitis (HP:0012387)1.70618941
157Pulmonary hypertension (HP:0002092)1.70162810
158Hyporeflexia of lower limbs (HP:0002600)1.70003087
159Abnormality of the columella (HP:0009929)1.69735916
160Hypoplasia of the iris (HP:0007676)1.68641217
161Large for gestational age (HP:0001520)1.68356879
162Neonatal short-limb short stature (HP:0008921)1.67909192
163Glomerulonephritis (HP:0000099)1.67614858
164Skin nodule (HP:0200036)1.67013149
165Round ear (HP:0100830)1.66831720
166Deformed sella turcica (HP:0002681)1.66674233
167Bulbar palsy (HP:0001283)1.66495859
168Lip pit (HP:0100267)1.66343619
169Spinal rigidity (HP:0003306)1.65504722
170Abnormality of complement system (HP:0005339)1.65286006
171Supernumerary ribs (HP:0005815)1.64822813
172Growth hormone excess (HP:0000845)1.64747424
173Bradycardia (HP:0001662)1.64415260
174Abnormality of the 2nd finger (HP:0004100)1.62580073
175Blue irides (HP:0000635)1.61599277
176Dysostosis multiplex (HP:0000943)1.60501123
177Narrow palate (HP:0000189)1.59861878
178Rectal prolapse (HP:0002035)1.57107572
179Acanthosis nigricans (HP:0000956)1.56367386
180Mildly elevated creatine phosphokinase (HP:0008180)1.56185734
181Aplasia/Hypoplasia of the hallux (HP:0008362)1.56159525
182Steppage gait (HP:0003376)1.55893733

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.32130648
2TXK4.71321679
3MAP3K143.34936054
4ZAP702.57492833
5MAP3K102.56285436
6AKT32.50870818
7IKBKB2.49299667
8ITK2.46137171
9EEF2K2.44488718
10CHUK2.43042290
11TGFBR22.25199299
12PDK22.10513476
13IKBKE2.07045055
14EPHB12.06897924
15JAK32.04059725
16NLK2.00455921
17MYLK1.97237400
18ICK1.97020306
19PIM21.96181260
20EPHA31.94665752
21STK101.91207074
22MAP2K31.88355232
23FGFR41.84555600
24TSSK61.83736161
25TBK11.77770103
26CDK121.74660363
27MAPK151.72023693
28EPHA21.69654796
29PIM11.63054229
30TYK21.51503003
31GRK61.51004102
32RPS6KA41.50287452
33MAP3K31.49676600
34FGFR31.45569227
35CDC42BPA1.37874288
36TEC1.35766109
37MAPK121.34250508
38ERN11.29689009
39HCK1.29267215
40RIPK11.27979546
41TAOK11.27742589
42RPS6KA21.27631238
43LCK1.16186974
44RPS6KL11.14117456
45RPS6KC11.14117456
46MAP3K111.10714322
47JAK11.08798949
48BTK1.06562406
49MAPKAPK31.04817819
50TRIB31.01709946
51IRAK31.01484228
52MAP3K60.98972251
53CAMK1D0.95547103
54PDGFRB0.94772956
55PRKCH0.93753945
56TNK20.91451817
57MAPK70.91033260
58NME10.90557599
59CSK0.88921074
60BRD40.88153181
61NEK60.87505725
62TRPM70.85689276
63TGFBR10.85475300
64HIPK20.85365982
65MAP3K70.84928705
66MAP2K20.84239891
67DAPK20.83324557
68JAK20.80699036
69MAP3K10.79915153
70MARK30.79724432
71* RPS6KA10.79476373
72DMPK0.79133039
73SIK30.73090952
74KDR0.73046038
75MST40.71964445
76PRKD10.71769508
77TIE10.71398070
78PRPF4B0.70885361
79GSK3A0.70425514
80SYK0.69021920
81TAOK30.68540853
82MAP3K130.68303961
83FER0.67149858
84PDPK10.67137137
85PTK60.66800755
86RAF10.66711742
87STK380.65888425
88PRKAA20.64899068
89MELK0.64685322
90ALK0.64372246
91LRRK20.62850746
92PIK3CG0.61334758
93SGK20.59869669
94CAMK10.59193698
95CLK10.58887000
96CDK90.58777092
97PAK20.57772606
98FGFR10.57525968
99PRKCQ0.57035059
100LATS20.55759240
101MAP2K60.55612370
102LATS10.54917105
103TYRO30.54581972
104CDK30.53975009
105RPS6KA60.53337300
106SGK2230.52407947
107SGK4940.52407947
108FES0.51076765
109IRAK10.50676625
110PRKAA10.50314405
111SIK10.49941390
112STK110.45813343
113SIK20.45040451
114KIT0.44916240
115PDGFRA0.44855000
116CAMK1G0.44677700
117TAOK20.44534208
118BMX0.44183653
119CAMK40.42276315
120ERBB20.41581941
121DDR20.41050155
122SGK30.41000142
123TTN0.40619068
124CAMKK10.40442914
125* MAPK80.40243354
126MAPK40.40024453
127IRAK20.39862666
128MAPKAPK20.39804721
129MTOR0.39238375
130MARK20.38406508
131PRKD20.37752030
132INSR0.37539669
133FRK0.37279311
134STK240.36966125
135MAPK100.36919226
136PKN20.36418001
137MAPK110.36244125
138MAPK30.35614304
139MAP3K20.32168263
140PDK10.32145931
141RET0.31646049
142* MAPK10.29017312

Predicted pathways (KEGG)

RankGene SetZ-score
1T cell receptor signaling pathway_Homo sapiens_hsa046603.21990152
2Osteoclast differentiation_Homo sapiens_hsa043803.04622284
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.89659292
4Primary immunodeficiency_Homo sapiens_hsa053402.85701632
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.79619270
6Allograft rejection_Homo sapiens_hsa053302.23268965
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.19223693
8Acute myeloid leukemia_Homo sapiens_hsa052212.09747660
9TNF signaling pathway_Homo sapiens_hsa046682.07139452
10Leishmaniasis_Homo sapiens_hsa051402.05144195
11Measles_Homo sapiens_hsa051622.00487494
12B cell receptor signaling pathway_Homo sapiens_hsa046621.98682087
13Toxoplasmosis_Homo sapiens_hsa051451.91802107
14Prolactin signaling pathway_Homo sapiens_hsa049171.91404983
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.79503426
16Hepatitis B_Homo sapiens_hsa051611.76644344
17Ovarian steroidogenesis_Homo sapiens_hsa049131.73872256
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.69515863
19Chronic myeloid leukemia_Homo sapiens_hsa052201.66711285
20Other glycan degradation_Homo sapiens_hsa005111.64681076
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.51698819
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.50973892
23Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.48964867
24Autoimmune thyroid disease_Homo sapiens_hsa053201.47070949
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.43076188
26Vascular smooth muscle contraction_Homo sapiens_hsa042701.42788968
27HTLV-I infection_Homo sapiens_hsa051661.36839498
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.36124283
29ECM-receptor interaction_Homo sapiens_hsa045121.35796871
30Asthma_Homo sapiens_hsa053101.32701665
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31396286
32Antigen processing and presentation_Homo sapiens_hsa046121.31208381
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.27796551
34Herpes simplex infection_Homo sapiens_hsa051681.24982121
35Legionellosis_Homo sapiens_hsa051341.24572448
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.22924018
37Circadian rhythm_Homo sapiens_hsa047101.22513327
38Apoptosis_Homo sapiens_hsa042101.22293487
39Graft-versus-host disease_Homo sapiens_hsa053321.20506665
40GnRH signaling pathway_Homo sapiens_hsa049121.20051053
41Influenza A_Homo sapiens_hsa051641.19680006
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19312099
43Colorectal cancer_Homo sapiens_hsa052101.18663959
44* MAPK signaling pathway_Homo sapiens_hsa040101.17622631
45Dilated cardiomyopathy_Homo sapiens_hsa054141.16263860
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.15184460
47Chemokine signaling pathway_Homo sapiens_hsa040621.13007281
48Viral myocarditis_Homo sapiens_hsa054161.10867408
49Adipocytokine signaling pathway_Homo sapiens_hsa049201.10143184
50VEGF signaling pathway_Homo sapiens_hsa043701.09722034
51Small cell lung cancer_Homo sapiens_hsa052221.08249315
52Pancreatic cancer_Homo sapiens_hsa052121.08029577
53Type II diabetes mellitus_Homo sapiens_hsa049301.06953668
54Leukocyte transendothelial migration_Homo sapiens_hsa046701.06448691
55cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05549347
56Amphetamine addiction_Homo sapiens_hsa050311.05078365
57ABC transporters_Homo sapiens_hsa020101.04758313
58Bile secretion_Homo sapiens_hsa049761.03677950
59Shigellosis_Homo sapiens_hsa051311.03639629
60Oxytocin signaling pathway_Homo sapiens_hsa049211.01744974
61Renin secretion_Homo sapiens_hsa049241.01050075
62Platelet activation_Homo sapiens_hsa046110.99812199
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.99339176
64Viral carcinogenesis_Homo sapiens_hsa052030.99150102
65Complement and coagulation cascades_Homo sapiens_hsa046100.97385803
66Hepatitis C_Homo sapiens_hsa051600.97207481
67Insulin resistance_Homo sapiens_hsa049310.97115781
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97110309
69Malaria_Homo sapiens_hsa051440.95284185
70FoxO signaling pathway_Homo sapiens_hsa040680.91136517
71Gastric acid secretion_Homo sapiens_hsa049710.88864098
72Notch signaling pathway_Homo sapiens_hsa043300.87707671
73Epstein-Barr virus infection_Homo sapiens_hsa051690.87598530
74Type I diabetes mellitus_Homo sapiens_hsa049400.86908319
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85681739
76Hematopoietic cell lineage_Homo sapiens_hsa046400.85647210
77Lysine degradation_Homo sapiens_hsa003100.84950482
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84571873
79cAMP signaling pathway_Homo sapiens_hsa040240.83571066
80Glucagon signaling pathway_Homo sapiens_hsa049220.82908098
81Prion diseases_Homo sapiens_hsa050200.82421427
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80828778
83Insulin secretion_Homo sapiens_hsa049110.79227945
84Pertussis_Homo sapiens_hsa051330.78879583
85Insulin signaling pathway_Homo sapiens_hsa049100.78599372
86Renal cell carcinoma_Homo sapiens_hsa052110.77893799
87Salmonella infection_Homo sapiens_hsa051320.77732638
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.77597370
89Dorso-ventral axis formation_Homo sapiens_hsa043200.75602150
90Endometrial cancer_Homo sapiens_hsa052130.71971764
91AMPK signaling pathway_Homo sapiens_hsa041520.71463994
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69254532
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68163292
94Prostate cancer_Homo sapiens_hsa052150.67910438
95Protein digestion and absorption_Homo sapiens_hsa049740.67151121
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66468574
97Amoebiasis_Homo sapiens_hsa051460.65945992
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65650665
99MicroRNAs in cancer_Homo sapiens_hsa052060.65489789
100Cocaine addiction_Homo sapiens_hsa050300.65456099
101Estrogen signaling pathway_Homo sapiens_hsa049150.64672123
102Circadian entrainment_Homo sapiens_hsa047130.64011711
103Thyroid hormone synthesis_Homo sapiens_hsa049180.63685190
104Adherens junction_Homo sapiens_hsa045200.63652358
105Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63630498
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62669962
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62383774
108Salivary secretion_Homo sapiens_hsa049700.61187028
109Rheumatoid arthritis_Homo sapiens_hsa053230.60739992
110ErbB signaling pathway_Homo sapiens_hsa040120.60710645
111Tight junction_Homo sapiens_hsa045300.60182012
112Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59521360
113Non-small cell lung cancer_Homo sapiens_hsa052230.59503635
114Thyroid cancer_Homo sapiens_hsa052160.59268578
115mTOR signaling pathway_Homo sapiens_hsa041500.58762566
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58242064
117Tuberculosis_Homo sapiens_hsa051520.57892852
118HIF-1 signaling pathway_Homo sapiens_hsa040660.57439973
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56948498
120Proteoglycans in cancer_Homo sapiens_hsa052050.56650398
121Mineral absorption_Homo sapiens_hsa049780.54546476
122Calcium signaling pathway_Homo sapiens_hsa040200.54372339
123Bladder cancer_Homo sapiens_hsa052190.54133150
124Pathways in cancer_Homo sapiens_hsa052000.53982260
125Cholinergic synapse_Homo sapiens_hsa047250.53460291
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53324946
127Histidine metabolism_Homo sapiens_hsa003400.53288075
128Choline metabolism in cancer_Homo sapiens_hsa052310.53053233
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52504201
130TGF-beta signaling pathway_Homo sapiens_hsa043500.52085188
131Inositol phosphate metabolism_Homo sapiens_hsa005620.51380542
132Focal adhesion_Homo sapiens_hsa045100.50960232
133Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48440600
134Rap1 signaling pathway_Homo sapiens_hsa040150.47382133
135* Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44693093
136Endocytosis_Homo sapiens_hsa041440.44682990
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.44071997
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.43903419
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43402853
140Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42761945

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