NR4A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tolerance induction (GO:0002507)5.85395093
2positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)5.10784904
3regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)5.10784904
4pyrimidine nucleobase catabolic process (GO:0006208)4.96306140
5CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.88304838
6* dopaminergic neuron differentiation (GO:0071542)4.78057561
7endothelial cell chemotaxis (GO:0035767)4.56980093
8positive regulation of mRNA catabolic process (GO:0061014)4.54223716
9nucleobase catabolic process (GO:0046113)3.90802379
10regulation of T cell tolerance induction (GO:0002664)3.86511105
11regulation of mRNA catabolic process (GO:0061013)3.82947621
12neuron fate determination (GO:0048664)3.80624024
13endoderm formation (GO:0001706)3.79868053
14negative T cell selection (GO:0043383)3.72332160
15* dopamine biosynthetic process (GO:0042416)3.61139333
16negative thymic T cell selection (GO:0045060)3.54142742
17response to corticosterone (GO:0051412)3.51762589
18neuron cell-cell adhesion (GO:0007158)3.38657604
19negative regulation of T cell mediated immunity (GO:0002710)3.28883752
20regulation of chronic inflammatory response (GO:0002676)3.26858657
21regulation of cardioblast proliferation (GO:0003264)3.26368349
22regulation of secondary heart field cardioblast proliferation (GO:0003266)3.26368349
23regulation of isotype switching to IgG isotypes (GO:0048302)3.25712204
24activated T cell proliferation (GO:0050798)3.22537397
25regulation of germinal center formation (GO:0002634)3.21493398
26regulation of timing of cell differentiation (GO:0048505)3.17764576
27catecholamine transport (GO:0051937)3.17507500
28positive thymic T cell selection (GO:0045059)3.14039594
29T cell lineage commitment (GO:0002360)3.13350821
30dopamine transport (GO:0015872)3.12906304
31adaptation of signaling pathway (GO:0023058)3.12875105
32definitive hemopoiesis (GO:0060216)3.10553435
33response to mineralocorticoid (GO:0051385)3.10394622
34CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.08033782
35regulation of gamma-delta T cell differentiation (GO:0045586)3.06839035
36response to muramyl dipeptide (GO:0032495)3.06183549
37positive regulation of astrocyte differentiation (GO:0048711)3.04343704
38positive regulation of response to oxidative stress (GO:1902884)3.02065068
39positive regulation of cellular response to oxidative stress (GO:1900409)3.02065068
40T cell selection (GO:0045058)3.01523125
41positive regulation of tolerance induction (GO:0002645)2.99672195
42regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.99058854
43positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.99058854
44vocalization behavior (GO:0071625)2.97965765
45radial glial cell differentiation (GO:0060019)2.97769013
46regulation of interleukin-12 biosynthetic process (GO:0045075)2.97162591
47regulation of gamma-delta T cell activation (GO:0046643)2.94895750
48midbrain development (GO:0030901)2.94389768
49positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.90600282
50negative regulation of gluconeogenesis (GO:0045721)2.90416648
51positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.88900725
52RNA destabilization (GO:0050779)2.86450408
53positive regulation of mRNA metabolic process (GO:1903313)2.83998906
54DNA damage response, detection of DNA damage (GO:0042769)2.82593099
55cAMP catabolic process (GO:0006198)2.82298813
56positive regulation of mRNA 3-end processing (GO:0031442)2.82140572
57positive regulation of mRNA processing (GO:0050685)2.81329535
58regulation of alpha-beta T cell proliferation (GO:0046640)2.80966559
59regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.80156369
60positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.78436581
61negative regulation of interleukin-1 beta production (GO:0032691)2.77701374
62alpha-beta T cell activation (GO:0046631)2.74444634
63defense response to protozoan (GO:0042832)2.74190342
64regulation of development, heterochronic (GO:0040034)2.73666409
65thymic T cell selection (GO:0045061)2.72062582
66negative regulation of JUN kinase activity (GO:0043508)2.70735097
67response to gravity (GO:0009629)2.68906171
68negative regulation of inclusion body assembly (GO:0090084)2.67678482
69cellular response to interleukin-15 (GO:0071350)2.66916732
70neuron recognition (GO:0008038)2.66610999
71regulation of tolerance induction (GO:0002643)2.65152103
72positive regulation of T cell differentiation in thymus (GO:0033089)2.62988536
73response to protozoan (GO:0001562)2.62684018
74CD4-positive, alpha-beta T cell activation (GO:0035710)2.61611380
75regulation of immunoglobulin secretion (GO:0051023)2.60828930
76dendritic spine morphogenesis (GO:0060997)2.60175800
77negative regulation of cell killing (GO:0031342)2.59396154
78negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.59396154
79T cell migration (GO:0072678)2.57834529
80neuronal action potential (GO:0019228)2.57508330
81positive regulation of granulocyte differentiation (GO:0030854)2.57140976
82facial nerve structural organization (GO:0021612)2.56827794
83histone H3-K4 trimethylation (GO:0080182)2.56177831
84regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.55605019
85negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.53808788
86negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.53753764
87negative regulation of translation, ncRNA-mediated (GO:0040033)2.53753764
88regulation of translation, ncRNA-mediated (GO:0045974)2.53753764
89negative regulation of T-helper cell differentiation (GO:0045623)2.53615747
90negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.53615747
91regulation of regulatory T cell differentiation (GO:0045589)2.53541888
92cell migration involved in sprouting angiogenesis (GO:0002042)2.52982427
93regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.51919172
94negative regulation of adaptive immune response (GO:0002820)2.50165929
95positive regulation of natural killer cell differentiation (GO:0032825)2.49598799
96monocyte chemotaxis (GO:0002548)2.49263101
97interferon-gamma production (GO:0032609)2.49143812
98alpha-beta T cell differentiation involved in immune response (GO:0002293)2.48824933
99alpha-beta T cell activation involved in immune response (GO:0002287)2.48824933
100T cell differentiation involved in immune response (GO:0002292)2.48824933
101regulation of B cell receptor signaling pathway (GO:0050855)2.46337726
102positive regulation of interleukin-17 production (GO:0032740)2.45729819
103inactivation of MAPK activity (GO:0000188)2.44967459
104regulation of neuronal synaptic plasticity (GO:0048168)2.44733161
105positive regulation of glomerulus development (GO:0090193)2.44417023
106negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.44071889
107positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.43057061
108regulation of chemokine biosynthetic process (GO:0045073)2.42543239
109regulation of interleukin-2 biosynthetic process (GO:0045076)2.42413985
110positive regulation of interleukin-2 production (GO:0032743)2.42389824
111dendrite development (GO:0016358)2.42073439
112protein localization to synapse (GO:0035418)2.42020791
113regulation of T cell receptor signaling pathway (GO:0050856)2.41687882
114axonal fasciculation (GO:0007413)2.41674765
115regulation of T-helper 2 cell differentiation (GO:0045628)2.39886949
116positive regulation of B cell proliferation (GO:0030890)2.39597517
117cellular extravasation (GO:0045123)2.39569084
118cyclic nucleotide catabolic process (GO:0009214)2.39268482
119regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.39262267
120cerebellum development (GO:0021549)2.39168478
121positive regulation of metanephros development (GO:0072216)2.38538714
122negative regulation of B cell activation (GO:0050869)2.37820100
123serotonin metabolic process (GO:0042428)2.37548398
124response to interleukin-15 (GO:0070672)2.37475283
125regulation of glutamate receptor signaling pathway (GO:1900449)2.37055514
126negative regulation of cAMP-mediated signaling (GO:0043951)2.35886323
127embryonic hemopoiesis (GO:0035162)2.35814426
128negative regulation of lymphocyte mediated immunity (GO:0002707)2.35420630
129auditory behavior (GO:0031223)2.35116849
130regulation of short-term neuronal synaptic plasticity (GO:0048172)2.35072942
131negative regulation of interleukin-6 production (GO:0032715)2.34852012
132regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.34835888
133positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.34793183
134T cell receptor signaling pathway (GO:0050852)2.33533308
135ionotropic glutamate receptor signaling pathway (GO:0035235)2.33217888
136alternative mRNA splicing, via spliceosome (GO:0000380)2.32674656
137regulation of interleukin-2 production (GO:0032663)2.32287479
138positive regulation of calcium-mediated signaling (GO:0050850)2.32052462
139positive T cell selection (GO:0043368)2.31982194
140skeletal muscle cell differentiation (GO:0035914)2.31583666
141positive regulation of osteoclast differentiation (GO:0045672)2.31204210
142response to cocaine (GO:0042220)2.31125789
143regulation of long-term neuronal synaptic plasticity (GO:0048169)2.30682698
144entrainment of circadian clock by photoperiod (GO:0043153)2.30008635
145dentate gyrus development (GO:0021542)2.30006599
146mating behavior (GO:0007617)2.29159280
147antigen receptor-mediated signaling pathway (GO:0050851)2.28285609
148negative regulation of T cell receptor signaling pathway (GO:0050860)2.28082742
149negative regulation of alpha-beta T cell activation (GO:0046636)2.27477180
150positive regulation of gamma-delta T cell activation (GO:0046645)2.26867659
151negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.26754724
152glutamate secretion (GO:0014047)2.26631305
153regulation of alpha-beta T cell activation (GO:0046634)2.26261703
154dendrite morphogenesis (GO:0048813)2.25523141
155regulation of synapse structural plasticity (GO:0051823)2.24498186
156postsynaptic membrane organization (GO:0001941)2.23794859
157regulation of type B pancreatic cell apoptotic process (GO:2000674)2.23193128
158positive regulation of DNA recombination (GO:0045911)2.21218217
159positive regulation of synapse assembly (GO:0051965)2.21093128
160alpha-beta T cell differentiation (GO:0046632)2.18599960
161sleep (GO:0030431)2.18006192
162* central nervous system projection neuron axonogenesis (GO:0021952)2.17882670
163positive regulation of isotype switching (GO:0045830)2.17330273
164regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.16977134
165positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.16977134
166T-helper cell differentiation (GO:0042093)2.16879334
167CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.16879334
168drinking behavior (GO:0042756)2.15255752
169positive regulation of T cell apoptotic process (GO:0070234)2.14325628

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.25938209
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.63265638
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.59031480
4GBX2_23144817_ChIP-Seq_PC3_Human3.17542551
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.99000578
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.90563436
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.88198531
8IGF1R_20145208_ChIP-Seq_DFB_Human2.67441884
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.57475405
10TAF15_26573619_Chip-Seq_HEK293_Human2.35647294
11* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.32996685
12* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.31473895
13* EZH2_27304074_Chip-Seq_ESCs_Mouse2.27939833
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26944041
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.15507367
16* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.13184238
17* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.10162076
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.10071140
19* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.08144264
20* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.08144264
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.06318885
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04629654
23* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.01847148
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.01251690
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93527606
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91540956
27VDR_22108803_ChIP-Seq_LS180_Human1.87417691
28* RNF2_27304074_Chip-Seq_ESCs_Mouse1.87182505
29* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.81812340
30AR_21572438_ChIP-Seq_LNCaP_Human1.79837660
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.79792259
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.78867344
33MYB_26560356_Chip-Seq_TH2_Human1.78312784
34* EZH2_27294783_Chip-Seq_ESCs_Mouse1.76923190
35* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.68845207
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66952437
37* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66188841
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.62539373
39DROSHA_22980978_ChIP-Seq_HELA_Human1.60075096
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59561798
41TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57896941
42POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.57896941
43* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56551906
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55886658
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53304754
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.52696370
47RUNX_20019798_ChIP-Seq_JUKART_Human1.50914894
48* CBX2_27304074_Chip-Seq_ESCs_Mouse1.48634458
49PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46987360
50RNF2_27304074_Chip-Seq_NSC_Mouse1.43886878
51* P300_19829295_ChIP-Seq_ESCs_Human1.43605768
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.42172977
53* AHR_22903824_ChIP-Seq_MCF-7_Human1.41341105
54ZNF274_21170338_ChIP-Seq_K562_Hela1.38825845
55REST_21632747_ChIP-Seq_MESCs_Mouse1.37694130
56TP53_18474530_ChIP-ChIP_U2OS_Human1.35051657
57* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34041063
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33769535
59* RING1B_27294783_Chip-Seq_NPCs_Mouse1.33507051
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32133420
61* SMAD3_21741376_ChIP-Seq_EPCs_Human1.32044603
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31678001
63MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.31221324
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29748474
65IRF8_27001747_Chip-Seq_BMDM_Mouse1.26018989
66* RING1B_27294783_Chip-Seq_ESCs_Mouse1.25161800
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24902383
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24741026
69SCL_19346495_ChIP-Seq_HPC-7_Human1.24666475
70MYB_26560356_Chip-Seq_TH1_Human1.22983267
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22561558
72* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22427125
73GATA3_27048872_Chip-Seq_THYMUS_Human1.21775773
74IRF8_21731497_ChIP-ChIP_J774_Mouse1.21664248
75* TP63_19390658_ChIP-ChIP_HaCaT_Human1.21517721
76TRIM28_21343339_ChIP-Seq_HEK293_Human1.20509825
77EWS_26573619_Chip-Seq_HEK293_Human1.19471882
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18404570
79GATA3_26560356_Chip-Seq_TH2_Human1.17588881
80IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16107588
81EGR1_19374776_ChIP-ChIP_THP-1_Human1.15452756
82AR_25329375_ChIP-Seq_VCAP_Human1.14775025
83* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14037276
84* ARNT_22903824_ChIP-Seq_MCF-7_Human1.13514109
85STAT4_19710469_ChIP-ChIP_TH1__Mouse1.13294502
86IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.13148439
87SMAD4_21799915_ChIP-Seq_A2780_Human1.13011474
88BCAT_22108803_ChIP-Seq_LS180_Human1.12658544
89* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10675711
90* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10070083
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09707301
92* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06418310
93FLI1_27457419_Chip-Seq_LIVER_Mouse1.05190826
94NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04766650
95CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04576777
96FUS_26573619_Chip-Seq_HEK293_Human1.04436009
97PRDM14_20953172_ChIP-Seq_ESCs_Human1.04093024
98RXR_22108803_ChIP-Seq_LS180_Human1.03205013
99* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00919177
100VDR_24763502_ChIP-Seq_THP-1_Human1.00590394
101WT1_19549856_ChIP-ChIP_CCG9911_Human1.00452449
102CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99677648
103SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99297874
104* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96885518
105* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95677170
106* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95394261
107FLI1_21867929_ChIP-Seq_TH2_Mouse0.92765008
108ER_23166858_ChIP-Seq_MCF-7_Human0.92706530
109SMRT_27268052_Chip-Seq_Bcells_Human0.92215539
110REST_18959480_ChIP-ChIP_MESCs_Mouse0.90950229
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90650777
112TP53_16413492_ChIP-PET_HCT116_Human0.89829890
113* SOX2_21211035_ChIP-Seq_LN229_Gbm0.88974989
114ESR1_21235772_ChIP-Seq_MCF-7_Human0.88951273
115TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88870621
116ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88788843
117* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88308081
118RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87913065
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87883175
120RARB_27405468_Chip-Seq_BRAIN_Mouse0.86524728
121PCGF2_27294783_Chip-Seq_NPCs_Mouse0.86288924
122* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86078796
123CDX2_20551321_ChIP-Seq_CACO-2_Human0.85575084
124VDR_24787735_ChIP-Seq_THP-1_Human0.85350695
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85018438
126* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84926605
127IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84843376
128CBP_20019798_ChIP-Seq_JUKART_Human0.84843376
129* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.84809854
130* NANOG_18555785_Chip-Seq_ESCs_Mouse0.84657846
131MAF_26560356_Chip-Seq_TH1_Human0.84613278
132SMAD3_21741376_ChIP-Seq_HESCs_Human0.84401518
133NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.84143792
134SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84020785
135OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83392307

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.99787794
2MP0001501_abnormal_sleep_pattern3.86359440
3MP0005423_abnormal_somatic_nervous3.77094573
4MP0003880_abnormal_central_pattern3.69968812
5MP0002009_preneoplasia3.47460744
6MP0004859_abnormal_synaptic_plasticity3.31103920
7MP0000566_synostosis3.28681257
8MP0008004_abnormal_stomach_pH2.51022385
9MP0006276_abnormal_autonomic_nervous2.43288746
10* MP0001905_abnormal_dopamine_level2.30445579
11MP0003724_increased_susceptibility_to2.26284974
12MP0004510_myositis2.25865257
13MP0001188_hyperpigmentation2.19431394
14* MP0003635_abnormal_synaptic_transmissio2.09838797
15MP0001873_stomach_inflammation2.06737621
16MP0005646_abnormal_pituitary_gland2.03219232
17* MP0002063_abnormal_learning/memory/cond1.94704117
18MP0004742_abnormal_vestibular_system1.90174992
19MP0008995_early_reproductive_senescence1.82184639
20MP0002148_abnormal_hypersensitivity_rea1.78584336
21* MP0009745_abnormal_behavioral_response1.77699484
22MP0005409_darkened_coat_color1.72590938
23MP0003303_peritoneal_inflammation1.69291585
24MP0008961_abnormal_basal_metabolism1.65361052
25MP0004947_skin_inflammation1.65299028
26MP0006292_abnormal_olfactory_placode1.60918361
27* MP0002572_abnormal_emotion/affect_behav1.60892632
28MP0002557_abnormal_social/conspecific_i1.60870622
29MP0002166_altered_tumor_susceptibility1.60353842
30MP0005025_abnormal_response_to1.59942998
31MP0003763_abnormal_thymus_physiology1.59856812
32MP0002938_white_spotting1.58898979
33MP0001486_abnormal_startle_reflex1.56988684
34MP0006082_CNS_inflammation1.53872437
35MP0005310_abnormal_salivary_gland1.51761872
36MP0004270_analgesia1.51725636
37MP0009333_abnormal_splenocyte_physiolog1.49207722
38MP0002419_abnormal_innate_immunity1.48831341
39MP0000778_abnormal_nervous_system1.48600081
40MP0002138_abnormal_hepatobiliary_system1.45290935
41MP0009278_abnormal_bone_marrow1.44058415
42MP0002734_abnormal_mechanical_nocicepti1.42861020
43MP0005671_abnormal_response_to1.41030406
44MP0002735_abnormal_chemical_nociception1.40258800
45MP0004808_abnormal_hematopoietic_stem1.38617603
46MP0000716_abnormal_immune_system1.35599247
47MP0002909_abnormal_adrenal_gland1.35234659
48MP0002398_abnormal_bone_marrow1.32707989
49MP0001502_abnormal_circadian_rhythm1.31682142
50MP0002184_abnormal_innervation1.30586980
51MP0000631_abnormal_neuroendocrine_gland1.29286838
52MP0005187_abnormal_penis_morphology1.29158966
53MP0002064_seizures1.27400097
54MP0004381_abnormal_hair_follicle1.27137045
55MP0001533_abnormal_skeleton_physiology1.25658503
56MP0004924_abnormal_behavior1.25124178
57MP0005386_behavior/neurological_phenoty1.25124178
58MP0005000_abnormal_immune_tolerance1.22000849
59MP0001346_abnormal_lacrimal_gland1.21194804
60MP0003828_pulmonary_edema1.21186903
61MP0001529_abnormal_vocalization1.18836472
62MP0001986_abnormal_taste_sensitivity1.18585365
63MP0005174_abnormal_tail_pigmentation1.17058337
64MP0009379_abnormal_foot_pigmentation1.15436322
65MP0001968_abnormal_touch/_nociception1.14493752
66MP0005084_abnormal_gallbladder_morpholo1.14424007
67MP0000689_abnormal_spleen_morphology1.12192707
68MP0002998_abnormal_bone_remodeling1.10933310
69MP0002272_abnormal_nervous_system1.10647479
70MP0001440_abnormal_grooming_behavior1.09934172
71MP0002751_abnormal_autonomic_nervous1.09336263
72MP0002877_abnormal_melanocyte_morpholog1.08989242
73* MP0004811_abnormal_neuron_physiology1.08978273
74MP0002254_reproductive_system_inflammat1.08315205
75MP0001845_abnormal_inflammatory_respons1.05788573
76MP0001919_abnormal_reproductive_system1.04765803
77MP0004883_abnormal_blood_vessel1.04477089
78MP0009250_abnormal_appendicular_skeleto1.03052054
79MP0003122_maternal_imprinting1.01487389
80MP0002277_abnormal_respiratory_mucosa1.01256666
81MP0002006_tumorigenesis0.99806362
82MP0002722_abnormal_immune_system0.99021096
83MP0003436_decreased_susceptibility_to0.98454487
84MP0000049_abnormal_middle_ear0.97936421
85MP0001853_heart_inflammation0.97338163
86MP0010155_abnormal_intestine_physiology0.97199923
87MP0003786_premature_aging0.95962067
88MP0003938_abnormal_ear_development0.95362652
89MP0010030_abnormal_orbit_morphology0.93241589
90MP0003787_abnormal_imprinting0.89185744
91MP0002638_abnormal_pupillary_reflex0.88556310
92MP0005387_immune_system_phenotype0.88528656
93MP0001790_abnormal_immune_system0.88528656
94MP0002405_respiratory_system_inflammati0.88173241
95MP0001970_abnormal_pain_threshold0.88127603
96MP0003866_abnormal_defecation0.87493238
97MP0002933_joint_inflammation0.87476109
98MP0001851_eye_inflammation0.86953514
99MP0002429_abnormal_blood_cell0.86797868
100* MP0002067_abnormal_sensory_capabilities0.86606720
101MP0009785_altered_susceptibility_to0.86370340
102MP0009764_decreased_sensitivity_to0.85080196
103MP0005508_abnormal_skeleton_morphology0.84599325
104MP0000685_abnormal_immune_system0.83721786
105MP0002723_abnormal_immune_serum0.83570944
106MP0005390_skeleton_phenotype0.83125326
107MP0000465_gastrointestinal_hemorrhage0.82438962
108MP0001545_abnormal_hematopoietic_system0.82049670
109MP0005397_hematopoietic_system_phenotyp0.82049670
110MP0002177_abnormal_outer_ear0.81936383
111MP0003045_fibrosis0.81298492
112MP0003959_abnormal_lean_body0.80350085
113MP0001835_abnormal_antigen_presentation0.78358015
114MP0000955_abnormal_spinal_cord0.78026482
115MP0002420_abnormal_adaptive_immunity0.77927662
116MP0005164_abnormal_response_to0.77782046
117MP0001800_abnormal_humoral_immune0.77424165
118MP0001879_abnormal_lymphatic_vessel0.76345351
119MP0005535_abnormal_body_temperature0.76108854
120MP0005645_abnormal_hypothalamus_physiol0.75785152
121MP0001819_abnormal_immune_cell0.75618786
122MP0000026_abnormal_inner_ear0.75350490
123MP0002116_abnormal_craniofacial_bone0.74550234
124MP0002452_abnormal_antigen_presenting0.74491534
125MP0008569_lethality_at_weaning0.74047604
126MP0008469_abnormal_protein_level0.71720079
127MP0005448_abnormal_energy_balance0.71688655
128MP0005503_abnormal_tendon_morphology0.71174580
129MP0003183_abnormal_peptide_metabolism0.70305595
130MP0005166_decreased_susceptibility_to0.70284317
131MP0002693_abnormal_pancreas_physiology0.70245227
132MP0000015_abnormal_ear_pigmentation0.70192797
133MP0004142_abnormal_muscle_tone0.69467615
134MP0001542_abnormal_bone_strength0.69386705
135MP0003091_abnormal_cell_migration0.68044711
136MP0000249_abnormal_blood_vessel0.67421101
137MP0002163_abnormal_gland_morphology0.66849819
138MP0000703_abnormal_thymus_morphology0.66551006
139MP0002928_abnormal_bile_duct0.65444471
140MP0002733_abnormal_thermal_nociception0.65380094

Predicted human phenotypes

RankGene SetZ-score
1Limb dystonia (HP:0002451)5.28477492
2Abnormal hair whorl (HP:0010721)3.75424099
3Focal motor seizures (HP:0011153)3.61234186
4Urethral obstruction (HP:0000796)3.58413996
5Upper limb muscle weakness (HP:0003484)3.57990364
6Down-sloping shoulders (HP:0200021)3.34492326
7Failure to thrive in infancy (HP:0001531)3.18463706
8Hyperventilation (HP:0002883)3.17817110
9Morphological abnormality of the middle ear (HP:0008609)3.17419274
10Autoimmune hemolytic anemia (HP:0001890)3.14527149
11Stomatitis (HP:0010280)3.08007681
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.05496421
13Ulnar claw (HP:0001178)3.05282712
14Lower limb amyotrophy (HP:0007210)3.04827117
15Febrile seizures (HP:0002373)3.02301361
16Peripheral hypomyelination (HP:0007182)2.96275689
17Narrow nasal bridge (HP:0000446)2.95424250
18Abnormality of eosinophils (HP:0001879)2.86876235
19Hypothermia (HP:0002045)2.86428051
20Chin dimple (HP:0010751)2.86006848
21Distal lower limb amyotrophy (HP:0008944)2.80780576
22Pulmonary infiltrates (HP:0002113)2.77915563
23Exotropia (HP:0000577)2.77091833
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.76234372
25Anterior segment dysgenesis (HP:0007700)2.75240149
26Interstitial pulmonary disease (HP:0006530)2.73161257
27Abnormality of T cell number (HP:0011839)2.73080147
28Retrobulbar optic neuritis (HP:0100654)2.71313832
29Optic neuritis (HP:0100653)2.71313832
30Abnormality of the intervertebral disk (HP:0005108)2.68832201
31Leukocytosis (HP:0001974)2.67833413
32Eosinophilia (HP:0001880)2.63074897
33Congenital stationary night blindness (HP:0007642)2.57717056
34Mediastinal lymphadenopathy (HP:0100721)2.56802461
35Glomerulopathy (HP:0100820)2.55997120
36Obstructive sleep apnea (HP:0002870)2.53576629
37Vasculitis (HP:0002633)2.51602807
38Severe combined immunodeficiency (HP:0004430)2.50409896
39Chronic sinusitis (HP:0011109)2.50382999
40Mutism (HP:0002300)2.48679790
41Nasal speech (HP:0001611)2.47365143
42Pustule (HP:0200039)2.46721136
43Genetic anticipation (HP:0003743)2.45590764
44Lip pit (HP:0100267)2.44596076
45Generalized hypopigmentation of hair (HP:0011358)2.44283612
46Autoimmune thrombocytopenia (HP:0001973)2.42131455
47Visual hallucinations (HP:0002367)2.40462069
48Progressive cerebellar ataxia (HP:0002073)2.40405296
49Recurrent fungal infections (HP:0002841)2.37292058
50Abnormality of the nasal septum (HP:0000419)2.37281615
51Focal seizures (HP:0007359)2.36486232
52Eczematoid dermatitis (HP:0000976)2.36126884
53Heterochromia iridis (HP:0001100)2.35425216
54Mixed hearing impairment (HP:0000410)2.33202391
55Prostate neoplasm (HP:0100787)2.33198048
56T lymphocytopenia (HP:0005403)2.32674415
57Abnormality of T cells (HP:0002843)2.31826565
58Abnormal ciliary motility (HP:0012262)2.30504035
59Recurrent bronchitis (HP:0002837)2.29584770
60Fair hair (HP:0002286)2.29485606
61Acute lymphatic leukemia (HP:0006721)2.28236842
62IgG deficiency (HP:0004315)2.27621672
63Progressive inability to walk (HP:0002505)2.27050721
64Truncal ataxia (HP:0002078)2.26444654
65Stomach cancer (HP:0012126)2.26123206
66Broad-based gait (HP:0002136)2.24247483
67Congenital sensorineural hearing impairment (HP:0008527)2.23674269
68Widely spaced teeth (HP:0000687)2.23341811
69Submucous cleft hard palate (HP:0000176)2.22151508
70Granulocytopenia (HP:0001913)2.20206295
71Orchitis (HP:0100796)2.19262236
72Large for gestational age (HP:0001520)2.17528388
73Epileptic encephalopathy (HP:0200134)2.15837602
74Alveolar cell carcinoma (HP:0006519)2.13225683
75Abnormal tarsal ossification (HP:0008369)2.11248002
76Shoulder girdle muscle weakness (HP:0003547)2.09637337
77Gastrointestinal infarctions (HP:0005244)2.08848367
78Abnormality of the prostate (HP:0008775)2.08846205
79Protruding tongue (HP:0010808)2.07317632
80Pelvic girdle muscle weakness (HP:0003749)2.06625979
81Hydroureter (HP:0000072)2.06490477
82Abnormality of macrophages (HP:0004311)2.05591921
83Abnormal respiratory epithelium morphology (HP:0012253)2.05255225
84Abnormal respiratory motile cilium morphology (HP:0005938)2.05255225
85Hemoptysis (HP:0002105)2.03991304
86Episodic fever (HP:0001954)2.03167850
87Meningitis (HP:0001287)2.02189995
88Increased CSF protein (HP:0002922)2.01871218
89Joint swelling (HP:0001386)2.00121682
90Myositis (HP:0100614)1.98697691
91Abnormality of male internal genitalia (HP:0000022)1.98201374
92Tented upper lip vermilion (HP:0010804)1.98114796
93Oligodactyly (hands) (HP:0001180)1.96875192
94Abnormality of T cell physiology (HP:0011840)1.95697399
95Abnormal rod and cone electroretinograms (HP:0008323)1.95459008
96Thyroiditis (HP:0100646)1.95091934
97Bronchitis (HP:0012387)1.94998940
98Pulmonary fibrosis (HP:0002206)1.94624960
99Abnormal respiratory motile cilium physiology (HP:0012261)1.94565506
100Abnormality of the fingertips (HP:0001211)1.93941387
101Hypoplasia of the iris (HP:0007676)1.93800772
102Neoplasm of the tracheobronchial system (HP:0100552)1.92922763
103Recurrent bacterial skin infections (HP:0005406)1.92773788
104Labial hypoplasia (HP:0000066)1.92056033
105Sleep apnea (HP:0010535)1.91976516
106Prominent supraorbital ridges (HP:0000336)1.91941943
107Excessive salivation (HP:0003781)1.91812919
108Drooling (HP:0002307)1.91812919
109Amblyopia (HP:0000646)1.91693583
110Steppage gait (HP:0003376)1.90336900
111Panhypogammaglobulinemia (HP:0003139)1.88450790
112Type I diabetes mellitus (HP:0100651)1.87944243
113Diplopia (HP:0000651)1.87556443
114Abnormality of binocular vision (HP:0011514)1.87556443
115Metaphyseal dysplasia (HP:0100255)1.86842788
116Prolonged bleeding time (HP:0003010)1.86407102
117Abnormality of the renal cortex (HP:0011035)1.86016498
118Papilledema (HP:0001085)1.86004985
119Cupped ear (HP:0000378)1.84634460
120Hypoventilation (HP:0002791)1.84434089
121Aplasia involving bones of the upper limbs (HP:0009823)1.83479228
122Aplasia of the phalanges of the hand (HP:0009802)1.83479228
123Aplasia involving bones of the extremities (HP:0009825)1.83479228
124Supernumerary bones of the axial skeleton (HP:0009144)1.81997219
125Polyphagia (HP:0002591)1.81872278
126Accelerated skeletal maturation (HP:0005616)1.80369284
127Deep palmar crease (HP:0006191)1.80081735
128Esotropia (HP:0000565)1.79228705
129Stenosis of the external auditory canal (HP:0000402)1.78619589
130Elevated erythrocyte sedimentation rate (HP:0003565)1.78266717
131Attenuation of retinal blood vessels (HP:0007843)1.77869698
132Abnormal pupillary function (HP:0007686)1.76990313
133Recurrent sinusitis (HP:0011108)1.76528844
134Persistence of primary teeth (HP:0006335)1.76331720
135Growth hormone deficiency (HP:0000824)1.76225725
136Clumsiness (HP:0002312)1.75271891
137Chronic diarrhea (HP:0002028)1.75165313
138Ocular albinism (HP:0001107)1.74480560
139Abnormality of the musculature of the pelvis (HP:0001469)1.73580301
140Abnormality of the hip-girdle musculature (HP:0001445)1.73580301
141Increased IgM level (HP:0003496)1.73547156
142Rhinitis (HP:0012384)1.73371122
143Intestinal atresia (HP:0011100)1.73304494
144Keratoconjunctivitis (HP:0001096)1.73004343
145Agammaglobulinemia (HP:0004432)1.72916367
146Hemiplegia (HP:0002301)1.72454774
147Vertigo (HP:0002321)1.71317016
148Recurrent abscess formation (HP:0002722)1.70826836
149Sparse scalp hair (HP:0002209)1.70823614
150Inability to walk (HP:0002540)1.69820488
151Atonic seizures (HP:0010819)1.69659405
152Chronic mucocutaneous candidiasis (HP:0002728)1.69386032
153Recurrent cutaneous fungal infections (HP:0011370)1.69386032
154Progressive sensorineural hearing impairment (HP:0000408)1.68293400
155Atelectasis (HP:0100750)1.67719767
156Poor speech (HP:0002465)1.67686028
157Blue irides (HP:0000635)1.65284231
158Growth hormone excess (HP:0000845)1.65119467
159Myokymia (HP:0002411)1.64370365
160Abnormality of the pericardium (HP:0001697)1.63235422
161Gaze-evoked nystagmus (HP:0000640)1.62281621
162Distal lower limb muscle weakness (HP:0009053)1.61852853
163Keratoconjunctivitis sicca (HP:0001097)1.59949522
164Congenital, generalized hypertrichosis (HP:0004540)1.59839217

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK34.60235917
2TAOK33.99873823
3MARK12.89224019
4MAP3K122.61962722
5SIK22.55183485
6BMPR1B2.42500517
7TXK2.35978209
8MAP2K22.25331277
9MAP3K92.25277312
10MAPKAPK52.23704389
11IRAK41.99784135
12NTRK21.85740371
13MAP3K141.68108711
14TNK21.55561923
15ERBB31.55443170
16EPHA31.50419996
17NTRK31.46258027
18HIPK21.43842326
19MAP4K11.38457255
20IRAK21.34830798
21DYRK21.33919771
22TGFBR11.33155618
23CASK1.32842318
24MKNK21.32719268
25IRAK11.32237620
26MAPK121.31093319
27TNIK1.26381389
28CHUK1.25779576
29MAPK131.24412651
30IKBKB1.22663028
31ITK1.22423559
32MST41.22257736
33MAPK71.20860698
34MAP3K131.18657108
35IRAK31.15251215
36IKBKE1.14782297
37BTK1.14604852
38GRK61.10992996
39KSR11.06062799
40TRPM71.04836718
41NEK61.04260837
42ZAP701.04259131
43GSK3A1.03133358
44DYRK1A1.01981439
45MAPK41.00105152
46FGFR30.99305690
47BMPR20.98587767
48MINK10.98401447
49GRK50.97913926
50JAK30.97666411
51TYRO30.97593275
52ADRBK20.97440398
53FES0.94528265
54TSSK60.94250767
55MKNK10.93770486
56RPS6KA50.93243490
57SYK0.93220247
58MAP3K30.91437865
59MAP2K70.91433947
60JAK10.91279205
61SGK20.90819237
62MARK30.90508472
63DYRK30.90384526
64INSRR0.90200253
65TIE10.90077070
66FGFR40.89664799
67EPHB20.89337544
68PNCK0.86687349
69TLK10.86505378
70TEC0.84088168
71PASK0.84057733
72BCR0.81794118
73FRK0.80891652
74CDK50.80550553
75WNK30.79587355
76PHKG20.77776158
77PHKG10.77776158
78GRK70.76953239
79FGR0.76710888
80UHMK10.76066939
81CSNK1G30.72256634
82DAPK20.71257693
83AKT30.70635397
84PIM20.69342170
85CDK30.68958007
86KIT0.68824562
87SIK10.68433864
88MARK20.67267305
89MAPK150.65678526
90LYN0.65478004
91CSNK1G20.63287716
92RPS6KA20.62492334
93BLK0.60246865
94NLK0.59954294
95HCK0.59828304
96TBK10.58816812
97PLK20.58629693
98PIM10.58620848
99NME10.58176089
100PDGFRB0.58045116
101EPHA40.57982904
102MUSK0.57849270
103PRKCQ0.56732153
104CSK0.56515589
105SGK10.56053196
106CAMKK20.55922567
107NUAK10.55766914
108PTK2B0.53880244
109CAMK2A0.53688540
110FGFR20.53248100
111CSNK1G10.53076161
112TRIM280.52286508
113LCK0.52050325
114DYRK1B0.51925426
115CAMK2B0.51684819
116CAMK40.51509145
117SGK4940.50981541
118SGK2230.50981541
119PIK3CA0.50767012
120MAPK30.49543091
121RPS6KA40.48625904
122MAP2K60.48379472
123MAP3K110.48015207
124RIPK10.47765743
125MAP2K40.47211537
126BRD40.46186180
127PAK30.45861779
128TYK20.45394745
129ERBB20.45356431
130CDK80.45024424
131* RPS6KA10.44928585
132MAP2K30.44596643
133PKN10.43522952
134CSNK1A1L0.41894476
135MAP3K40.41639911
136CDK190.40492455
137GRK10.39857631
138DAPK10.39193970
139FYN0.38406937
140CAMKK10.37644995
141TGFBR20.37364399
142TAOK10.36514274
143JAK20.35484565
144PRKG10.34690595
145MAPK80.34306259
146RIPK40.33610597

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053322.77822858
2Cocaine addiction_Homo sapiens_hsa050302.20777423
3Nicotine addiction_Homo sapiens_hsa050332.19012777
4T cell receptor signaling pathway_Homo sapiens_hsa046602.04471161
5Amphetamine addiction_Homo sapiens_hsa050311.92063661
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.89436171
7Asthma_Homo sapiens_hsa053101.87363537
8Osteoclast differentiation_Homo sapiens_hsa043801.73244355
9African trypanosomiasis_Homo sapiens_hsa051431.66359064
10Allograft rejection_Homo sapiens_hsa053301.54731959
11Circadian entrainment_Homo sapiens_hsa047131.54068587
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.48825215
13TNF signaling pathway_Homo sapiens_hsa046681.48337170
14Rheumatoid arthritis_Homo sapiens_hsa053231.44235702
15Antigen processing and presentation_Homo sapiens_hsa046121.42020357
16Dopaminergic synapse_Homo sapiens_hsa047281.41400074
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.40448537
18Cholinergic synapse_Homo sapiens_hsa047251.39470726
19Serotonergic synapse_Homo sapiens_hsa047261.38016706
20Dorso-ventral axis formation_Homo sapiens_hsa043201.32132703
21Circadian rhythm_Homo sapiens_hsa047101.31892682
22Leishmaniasis_Homo sapiens_hsa051401.31702988
23Morphine addiction_Homo sapiens_hsa050321.31364566
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.30227039
25Glutamatergic synapse_Homo sapiens_hsa047241.30106841
26Notch signaling pathway_Homo sapiens_hsa043301.26613430
27Measles_Homo sapiens_hsa051621.24749735
28Type I diabetes mellitus_Homo sapiens_hsa049401.22963698
29Axon guidance_Homo sapiens_hsa043601.18129066
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14258461
31Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13044873
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13001757
33MAPK signaling pathway_Homo sapiens_hsa040101.12555007
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10581916
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09763861
36Long-term potentiation_Homo sapiens_hsa047201.09352733
37GABAergic synapse_Homo sapiens_hsa047271.08097695
38Staphylococcus aureus infection_Homo sapiens_hsa051501.06913871
39Salmonella infection_Homo sapiens_hsa051321.05542693
40Hepatitis B_Homo sapiens_hsa051611.04656936
41Primary immunodeficiency_Homo sapiens_hsa053401.03693953
42* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03434557
43ErbB signaling pathway_Homo sapiens_hsa040121.03172627
44Oxytocin signaling pathway_Homo sapiens_hsa049211.02908525
45Toll-like receptor signaling pathway_Homo sapiens_hsa046201.02032398
46Prolactin signaling pathway_Homo sapiens_hsa049171.00995974
47Colorectal cancer_Homo sapiens_hsa052101.00361609
48Long-term depression_Homo sapiens_hsa047300.99514785
49Malaria_Homo sapiens_hsa051440.98912064
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98538195
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97297163
52Renin secretion_Homo sapiens_hsa049240.95869176
53Olfactory transduction_Homo sapiens_hsa047400.95634568
54Pertussis_Homo sapiens_hsa051330.94911979
55B cell receptor signaling pathway_Homo sapiens_hsa046620.91828169
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91195222
57Gap junction_Homo sapiens_hsa045400.90636827
58Synaptic vesicle cycle_Homo sapiens_hsa047210.90052826
59Tuberculosis_Homo sapiens_hsa051520.89792886
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.88899646
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.87998544
62Chemokine signaling pathway_Homo sapiens_hsa040620.87513605
63Insulin secretion_Homo sapiens_hsa049110.84836328
64Hematopoietic cell lineage_Homo sapiens_hsa046400.84774153
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84391192
66Calcium signaling pathway_Homo sapiens_hsa040200.84028840
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81772177
68Chronic myeloid leukemia_Homo sapiens_hsa052200.81426734
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81019428
70FoxO signaling pathway_Homo sapiens_hsa040680.80906800
71Autoimmune thyroid disease_Homo sapiens_hsa053200.80787576
72cAMP signaling pathway_Homo sapiens_hsa040240.80299952
73Estrogen signaling pathway_Homo sapiens_hsa049150.80095554
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79833459
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76173827
76Toxoplasmosis_Homo sapiens_hsa051450.75998554
77GnRH signaling pathway_Homo sapiens_hsa049120.75487115
78Choline metabolism in cancer_Homo sapiens_hsa052310.73003353
79Phototransduction_Homo sapiens_hsa047440.72909796
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71727299
81VEGF signaling pathway_Homo sapiens_hsa043700.71704667
82Taste transduction_Homo sapiens_hsa047420.71068609
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.70309334
84Prion diseases_Homo sapiens_hsa050200.69276391
85Salivary secretion_Homo sapiens_hsa049700.68532221
86Acute myeloid leukemia_Homo sapiens_hsa052210.67510399
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65702104
88Gastric acid secretion_Homo sapiens_hsa049710.65503715
89Platelet activation_Homo sapiens_hsa046110.64755541
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63660946
91Shigellosis_Homo sapiens_hsa051310.63240042
92Influenza A_Homo sapiens_hsa051640.61472844
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61471844
94Wnt signaling pathway_Homo sapiens_hsa043100.61165508
95Viral myocarditis_Homo sapiens_hsa054160.59343386
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58950570
97Melanogenesis_Homo sapiens_hsa049160.58947456
98Rap1 signaling pathway_Homo sapiens_hsa040150.58829305
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58786617
100Ras signaling pathway_Homo sapiens_hsa040140.58600010
101Renal cell carcinoma_Homo sapiens_hsa052110.58040813
102Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57938360
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57803426
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.56851424
105HTLV-I infection_Homo sapiens_hsa051660.56627270
106Herpes simplex infection_Homo sapiens_hsa051680.55136172
107Legionellosis_Homo sapiens_hsa051340.54527492
108Regulation of autophagy_Homo sapiens_hsa041400.54074355
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53520196
110Type II diabetes mellitus_Homo sapiens_hsa049300.53253195
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53196908
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51498062
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50934129
114Pathways in cancer_Homo sapiens_hsa052000.50189548
115Ether lipid metabolism_Homo sapiens_hsa005650.47790269
116Linoleic acid metabolism_Homo sapiens_hsa005910.45705901
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44385536
118Ovarian steroidogenesis_Homo sapiens_hsa049130.44058749
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.41723368
120Apoptosis_Homo sapiens_hsa042100.41680755
121Nitrogen metabolism_Homo sapiens_hsa009100.40715532
122ABC transporters_Homo sapiens_hsa020100.40531034

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