NR4A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endothelial cell chemotaxis (GO:0035767)8.60040556
2regulation of gamma-delta T cell differentiation (GO:0045586)7.40206170
3regulation of interleukin-12 biosynthetic process (GO:0045075)7.17145005
4regulation of gamma-delta T cell activation (GO:0046643)6.81889799
5positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.17650410
6NIK/NF-kappaB signaling (GO:0038061)5.80551020
7positive thymic T cell selection (GO:0045059)5.18470827
8positive regulation of chemokine biosynthetic process (GO:0045080)5.17176586
9positive regulation of gamma-delta T cell activation (GO:0046645)5.02413791
10negative thymic T cell selection (GO:0045060)4.89827200
11regulation of immunoglobulin secretion (GO:0051023)4.89161045
12myeloid dendritic cell differentiation (GO:0043011)4.82012544
13regulation of chemokine biosynthetic process (GO:0045073)4.77315612
14negative T cell selection (GO:0043383)4.74443664
15interferon-gamma production (GO:0032609)4.64523706
16positive T cell selection (GO:0043368)4.46476543
17thymic T cell selection (GO:0045061)4.44755016
18regulation of isotype switching to IgG isotypes (GO:0048302)4.39071829
19negative regulation of cell killing (GO:0031342)4.38539449
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.38539449
21cell migration involved in sprouting angiogenesis (GO:0002042)4.32098862
22regulation of fever generation (GO:0031620)4.29847672
23positive regulation of interleukin-2 production (GO:0032743)4.28339745
24positive regulation of interleukin-10 production (GO:0032733)4.28253861
25response to interleukin-15 (GO:0070672)4.23742602
26regulation of T-helper 1 cell differentiation (GO:0045625)4.22980764
27myeloid dendritic cell activation (GO:0001773)4.22395625
28positive regulation of heat generation (GO:0031652)4.20543139
29positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.17982410
30defense response to protozoan (GO:0042832)4.16733037
31regulation of interleukin-2 biosynthetic process (GO:0045076)4.16108536
32regulation of regulatory T cell differentiation (GO:0045589)4.15894449
33T cell selection (GO:0045058)4.12638267
34response to peptidoglycan (GO:0032494)4.10353342
35JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)4.05568849
36tolerance induction (GO:0002507)4.04313220
37response to protozoan (GO:0001562)3.98967340
38positive regulation of isotype switching (GO:0045830)3.96473663
39cellular response to interleukin-15 (GO:0071350)3.91383719
40cellular response to nicotine (GO:0071316)3.90061662
41positive regulation of humoral immune response (GO:0002922)3.89554329
42CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.88019866
43negative regulation of interleukin-12 production (GO:0032695)3.87692779
44regulation of vitamin D biosynthetic process (GO:0060556)3.84121992
45positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.82594351
46positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.80815689
47positive regulation of T cell differentiation in thymus (GO:0033089)3.77406754
48T-helper cell differentiation (GO:0042093)3.75844728
49CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.75844728
50positive regulation of interleukin-17 production (GO:0032740)3.74940021
51regulation of interferon-gamma biosynthetic process (GO:0045072)3.74795341
52regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.72551475
53positive regulation of interleukin-12 production (GO:0032735)3.69841674
54positive regulation of natural killer cell activation (GO:0032816)3.67421697
55tyrosine phosphorylation of STAT protein (GO:0007260)3.64771896
56negative regulation of nitric oxide biosynthetic process (GO:0045019)3.64394677
57response to muramyl dipeptide (GO:0032495)3.57587514
58germinal center formation (GO:0002467)3.57355364
59regulation of alpha-beta T cell proliferation (GO:0046640)3.55403751
60regulation of chronic inflammatory response (GO:0002676)3.54619382
61regulation of T cell tolerance induction (GO:0002664)3.53733449
62positive regulation of B cell mediated immunity (GO:0002714)3.53386632
63positive regulation of immunoglobulin mediated immune response (GO:0002891)3.53386632
64positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.52795644
65regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.52663475
66regulation of podosome assembly (GO:0071801)3.52087513
67lipopolysaccharide-mediated signaling pathway (GO:0031663)3.51484549
68antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.49265302
69antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.49265302
70antigen processing and presentation of endogenous antigen (GO:0019883)3.48645057
71regulation of T-helper cell differentiation (GO:0045622)3.47108905
72positive regulation of B cell proliferation (GO:0030890)3.46234772
73positive regulation of DNA recombination (GO:0045911)3.44608621
74positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.43279543
75leukocyte aggregation (GO:0070486)3.40779173
76positive regulation of NF-kappaB import into nucleus (GO:0042346)3.40560421
77positive regulation of T-helper cell differentiation (GO:0045624)3.40480786
78negative regulation of T cell differentiation in thymus (GO:0033085)3.36755094
79regulation of vitamin metabolic process (GO:0030656)3.36374540
80alpha-beta T cell differentiation (GO:0046632)3.35374966
81regulation of natural killer cell differentiation (GO:0032823)3.35200269
82regulation of interleukin-12 production (GO:0032655)3.34355773
83positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.34192237
84alpha-beta T cell differentiation involved in immune response (GO:0002293)3.32310265
85alpha-beta T cell activation involved in immune response (GO:0002287)3.32310265
86T cell differentiation involved in immune response (GO:0002292)3.32310265
87regulation of interleukin-10 production (GO:0032653)3.31867557
88positive regulation of type 2 immune response (GO:0002830)3.31698737
89positive regulation of T cell differentiation (GO:0045582)3.30801420
90regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.28990995
91positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.28967559
92positive regulation of T cell apoptotic process (GO:0070234)3.28596777
93positive regulation of activated T cell proliferation (GO:0042104)3.27944712
94T cell migration (GO:0072678)3.26123357
95T-helper 1 type immune response (GO:0042088)3.25593581
96T cell receptor signaling pathway (GO:0050852)3.24652560
97alpha-beta T cell activation (GO:0046631)3.24570115
98negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.23848820
99negative regulation of T-helper cell differentiation (GO:0045623)3.23848820
100regulation of heat generation (GO:0031650)3.23487809
101regulation of interleukin-17 production (GO:0032660)3.23459073
102growth hormone receptor signaling pathway (GO:0060396)3.22882629
103regulation of nitric oxide biosynthetic process (GO:0045428)3.19739330
104regulation of interferon-alpha production (GO:0032647)3.19021623
105positive regulation of natural killer cell differentiation (GO:0032825)3.16746221
106regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.16642083
107regulation of memory T cell differentiation (GO:0043380)3.15094326
108regulation of T-helper 2 cell differentiation (GO:0045628)3.14881313
109positive regulation of alpha-beta T cell proliferation (GO:0046641)3.14096935
110regulation of dendritic cell antigen processing and presentation (GO:0002604)3.12684895
111regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.11578107
112dendritic cell differentiation (GO:0097028)3.11516376
113T cell costimulation (GO:0031295)3.11440119
114regulation of interleukin-2 production (GO:0032663)3.10699689
115cellular response to gonadotropin stimulus (GO:0071371)3.09393035
116positive regulation of nitric oxide biosynthetic process (GO:0045429)3.07874513
117type I interferon signaling pathway (GO:0060337)3.06840926
118cellular response to type I interferon (GO:0071357)3.06840926
119lymphocyte costimulation (GO:0031294)3.06724838
120regulation of T cell differentiation (GO:0045580)3.06033689
121regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.04528938
122positive regulation of cytokine biosynthetic process (GO:0042108)3.04002853
123response to type I interferon (GO:0034340)3.03756371
124positive regulation of acute inflammatory response (GO:0002675)3.02359632
125natural killer cell activation (GO:0030101)3.00625545
126regulation of T cell differentiation in thymus (GO:0033081)2.98521549
127regulation of isotype switching (GO:0045191)2.96666169
128negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.94269516
129tumor necrosis factor-mediated signaling pathway (GO:0033209)2.94211823
130regulation of NF-kappaB import into nucleus (GO:0042345)2.94165814
131regulation of thymocyte apoptotic process (GO:0070243)2.92955985
132regulation of cytokine secretion involved in immune response (GO:0002739)2.92910215
133regulation of natural killer cell activation (GO:0032814)2.92795014
134T cell lineage commitment (GO:0002360)2.92441459
135positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.90410309
136interferon-gamma-mediated signaling pathway (GO:0060333)2.90236377
137positive regulation of lymphocyte differentiation (GO:0045621)2.89088177
138regulation of interleukin-8 biosynthetic process (GO:0045414)2.88672712
139cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.87832398
140branching involved in labyrinthine layer morphogenesis (GO:0060670)2.87348392
141macrophage activation involved in immune response (GO:0002281)2.87297123
142regulation of alpha-beta T cell differentiation (GO:0046637)2.87280596
143positive regulation of prostaglandin secretion (GO:0032308)2.86115737
144positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.85755250
145production of molecular mediator of immune response (GO:0002440)2.85588179
146positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.85569060
147negative regulation of cytokine production involved in immune response (GO:0002719)2.84103780
148blood vessel endothelial cell migration (GO:0043534)2.83006333
149positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.82796698
150positive regulation of natural killer cell mediated immunity (GO:0002717)2.82796698
151positive regulation of astrocyte differentiation (GO:0048711)2.82446151
152regulation of response to interferon-gamma (GO:0060330)2.80775941
153regulation of membrane protein ectodomain proteolysis (GO:0051043)2.79492242
154activation of MAPKKK activity (GO:0000185)2.79135551
155cellular response to lipopolysaccharide (GO:0071222)2.77687130
156positive regulation of B cell activation (GO:0050871)2.76685666
157regulation of mononuclear cell migration (GO:0071675)2.75517831
158T cell activation involved in immune response (GO:0002286)2.72816136
159positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.72197679
160positive regulation of p38MAPK cascade (GO:1900745)2.71064046
161negative regulation of production of molecular mediator of immune response (GO:0002701)2.70553748
162positive regulation of interferon-gamma production (GO:0032729)2.69060676

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.95700267
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.39693751
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.36273212
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.29735755
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.25623478
6NOTCH1_21737748_ChIP-Seq_TLL_Human3.63367969
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.50945499
8RUNX_20019798_ChIP-Seq_JUKART_Human3.26950714
9* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.25736206
10* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.22246894
11STAT4_19710469_ChIP-ChIP_TH1__Mouse3.19033612
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.16541795
13* MYC_22102868_ChIP-Seq_BL_Human2.73385808
14* IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.59661305
15* MYB_26560356_Chip-Seq_TH2_Human2.58396559
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.54080567
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.48307556
18MAF_26560356_Chip-Seq_TH1_Human2.43239659
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.41202837
20* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.37995269
21* TCF7_22412390_ChIP-Seq_EML_Mouse2.30963814
22* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.28499532
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.26017721
24IRF8_21731497_ChIP-ChIP_J774_Mouse2.22936142
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.20168566
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17020196
27MYB_26560356_Chip-Seq_TH1_Human2.09578318
28* KDM2B_26808549_Chip-Seq_DND41_Human2.02114323
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.99573878
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.93989154
31* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.88972301
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.88019856
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.76178392
34UTX_26944678_Chip-Seq_JUKART_Human1.72596639
35GATA1_22025678_ChIP-Seq_K562_Human1.67699955
36* KDM2B_26808549_Chip-Seq_JURKAT_Human1.67637281
37VDR_24763502_ChIP-Seq_THP-1_Human1.61148819
38* GATA3_27048872_Chip-Seq_THYMUS_Human1.59365142
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.57789755
40KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.55066311
41KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.55066311
42KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.55066311
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53389239
44MAF_26560356_Chip-Seq_TH2_Human1.51568363
45VDR_21846776_ChIP-Seq_THP-1_Human1.49221290
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48227728
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.48001124
48CLOCK_20551151_ChIP-Seq_293T_Human1.47255477
49VDR_24787735_ChIP-Seq_THP-1_Human1.44941162
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.43464572
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40529189
52E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38334822
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.37438091
54EGR1_19032775_ChIP-ChIP_M12_Human1.35163663
55SCL_19346495_ChIP-Seq_HPC-7_Human1.34090325
56CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27105361
57KDM2B_26808549_Chip-Seq_K562_Human1.24934907
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.24371403
59FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.22067030
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21516315
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20137946
62* ELK3_25401928_ChIP-Seq_HUVEC_Human1.20038006
63RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.16117619
64HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14061146
65NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12333547
66PU_27001747_Chip-Seq_BMDM_Mouse1.11947195
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08154322
68FOXO3_23340844_ChIP-Seq_DLD1_Human1.07712771
69ZNF263_19887448_ChIP-Seq_K562_Human1.05658059
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05475656
71CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.05395990
72PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04888509
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04608910
74SPI1_23127762_ChIP-Seq_K562_Human1.01255102
75RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00298382
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00233370
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96865740
78WT1_19549856_ChIP-ChIP_CCG9911_Human0.96343256
79PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96035686
80* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95786179
81SMRT_27268052_Chip-Seq_Bcells_Human0.95100512
82NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94518562
83STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93909591
84CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93383259
85GATA1_19941826_ChIP-Seq_K562_Human0.93277769
86LXR_22158963_ChIP-Seq_LIVER_Mouse0.92877750
87GATA3_26560356_Chip-Seq_TH2_Human0.92744728
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92651904
89FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.92343425
90GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89884833
91* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87469358
92JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87434313
93WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87206235
94* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86653499
95AR_21572438_ChIP-Seq_LNCaP_Human0.86204504
96LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.85067749
97* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84575287
98* UBF1/2_26484160_Chip-Seq_HMECs_Human0.83510835
99* RUNX1_27514584_Chip-Seq_MCF-7_Human0.82497152
100LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.82055058
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81539483
102IKZF1_21737484_ChIP-ChIP_HCT116_Human0.81498120
103ZFP281_27345836_Chip-Seq_ESCs_Mouse0.79774856
104SPI1_23547873_ChIP-Seq_NB4_Human0.77520751
105* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76739739
106ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.76168852
107* CJUN_26792858_Chip-Seq_BT549_Human0.75537075
108* NCOR1_26117541_ChIP-Seq_K562_Human0.75511474
109TBX20_22080862_ChIP-Seq_HEART_Mouse0.74749339
110TBX20_22328084_ChIP-Seq_HEART_Mouse0.74749339
111CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.74545133
112GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74507969
113SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74424588
114PRDM14_20953172_ChIP-Seq_ESCs_Human0.73854743
115EP300_21415370_ChIP-Seq_HL-1_Mouse0.73338157
116ESR2_21235772_ChIP-Seq_MCF-7_Human0.72087829
117PPAR_26484153_Chip-Seq_NCI-H1993_Human0.72062685
118JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70697442
119* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.70637531
120* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.70637531
121ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.70632743
122* RACK7_27058665_Chip-Seq_MCF-7_Human0.70491357
123MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.70448381
124GATA1_19941827_ChIP-Seq_MEL_Mouse0.70162646
125* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.70086849
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.69892237
127NRF2_20460467_ChIP-Seq_MEFs_Mouse0.69892237
128SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.69529955
129ATF3_27146783_Chip-Seq_COLON_Human0.69192225
130NR3C1_23031785_ChIP-Seq_PC12_Mouse0.68446026
131* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.67858266
132* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.66403237

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004510_myositis4.72874944
2MP0003303_peritoneal_inflammation4.22006210
3MP0000685_abnormal_immune_system4.08740909
4MP0003763_abnormal_thymus_physiology4.00069056
5MP0005423_abnormal_somatic_nervous3.55038756
6MP0003436_decreased_susceptibility_to3.52695956
7MP0005671_abnormal_response_to3.34880615
8MP0001835_abnormal_antigen_presentation3.31283988
9MP0001790_abnormal_immune_system3.29942614
10MP0005387_immune_system_phenotype3.29942614
11MP0002138_abnormal_hepatobiliary_system3.11585690
12MP0005000_abnormal_immune_tolerance3.07335208
13MP0001853_heart_inflammation2.87928742
14MP0003300_gastrointestinal_ulcer2.87594007
15MP0001800_abnormal_humoral_immune2.79941333
16MP0002405_respiratory_system_inflammati2.74541104
17MP0009785_altered_susceptibility_to2.63530382
18MP0002723_abnormal_immune_serum2.60277116
19MP0008004_abnormal_stomach_pH2.58940553
20MP0009840_abnormal_foam_cell2.49333821
21MP0003646_muscle_fatigue2.46335034
22MP0002452_abnormal_antigen_presenting2.41635424
23MP0003724_increased_susceptibility_to2.35702687
24MP0002332_abnormal_exercise_endurance2.30695930
25MP0002420_abnormal_adaptive_immunity2.28725277
26MP0001819_abnormal_immune_cell2.28670313
27MP0002148_abnormal_hypersensitivity_rea2.27984822
28MP0003866_abnormal_defecation2.14485556
29MP0005025_abnormal_response_to2.10687121
30MP0002398_abnormal_bone_marrow2.08108569
31MP0002166_altered_tumor_susceptibility2.07609793
32MP0010155_abnormal_intestine_physiology2.05143477
33MP0004947_skin_inflammation2.04357907
34MP0005167_abnormal_blood-brain_barrier2.02778383
35MP0001348_abnormal_lacrimal_gland1.96158868
36MP0008961_abnormal_basal_metabolism1.94420883
37MP0002419_abnormal_innate_immunity1.94224860
38MP0002006_tumorigenesis1.89034596
39MP0000716_abnormal_immune_system1.88344065
40MP0000703_abnormal_thymus_morphology1.83357302
41MP0001873_stomach_inflammation1.79515466
42MP0005451_abnormal_body_composition1.77340967
43MP0000604_amyloidosis1.76259217
44MP0006082_CNS_inflammation1.76210926
45MP0004808_abnormal_hematopoietic_stem1.75198852
46MP0000343_altered_response_to1.64555198
47MP0005058_abnormal_lysosome_morphology1.63933023
48MP0009333_abnormal_splenocyte_physiolog1.61822472
49MP0001845_abnormal_inflammatory_respons1.60994233
50MP0005310_abnormal_salivary_gland1.60659217
51MP0001533_abnormal_skeleton_physiology1.56810392
52MP0002722_abnormal_immune_system1.56295409
53MP0000689_abnormal_spleen_morphology1.53401866
54MP0002998_abnormal_bone_remodeling1.49475994
55MP0003195_calcinosis1.43443782
56MP0002429_abnormal_blood_cell1.41250686
57MP0001851_eye_inflammation1.39766916
58MP0001501_abnormal_sleep_pattern1.34792949
59MP0005076_abnormal_cell_differentiation1.32106663
60MP0002933_joint_inflammation1.29240580
61MP0005164_abnormal_response_to1.28238108
62MP0002254_reproductive_system_inflammat1.27132840
63MP0000465_gastrointestinal_hemorrhage1.23381466
64MP0002277_abnormal_respiratory_mucosa1.21316572
65MP0002139_abnormal_hepatobiliary_system1.15840747
66MP0003690_abnormal_glial_cell1.15609801
67MP0001881_abnormal_mammary_gland1.13544664
68MP0003448_altered_tumor_morphology1.03168848
69MP0005464_abnormal_platelet_physiology0.96441501
70MP0005165_increased_susceptibility_to0.94982292
71MP0003172_abnormal_lysosome_physiology0.94278800
72MP0001502_abnormal_circadian_rhythm0.88907248
73MP0003075_altered_response_to0.87036989
74MP0003329_amyloid_beta_deposits0.85161183
75MP0010352_gastrointestinal_tract_polyps0.84841381
76MP0005390_skeleton_phenotype0.84495348
77MP0002009_preneoplasia0.84018981
78MP0008469_abnormal_protein_level0.83803016
79MP0001542_abnormal_bone_strength0.83173348
80MP0003795_abnormal_bone_structure0.82563251
81MP0002877_abnormal_melanocyte_morpholog0.82357683
82MP0009764_decreased_sensitivity_to0.82144239
83MP0004484_altered_response_of0.81885607
84MP0003453_abnormal_keratinocyte_physiol0.81432689
85MP0003828_pulmonary_edema0.81111097
86MP0000372_irregular_coat_pigmentation0.80479711
87MP0005397_hematopoietic_system_phenotyp0.80225441
88MP0001545_abnormal_hematopoietic_system0.80225441
89MP0003091_abnormal_cell_migration0.79888506
90MP0005647_abnormal_sex_gland0.79374142
91MP0003656_abnormal_erythrocyte_physiolo0.79015814
92MP0006054_spinal_hemorrhage0.77907617
93MP0002396_abnormal_hematopoietic_system0.77863701
94MP0009278_abnormal_bone_marrow0.77626257
95MP0008057_abnormal_DNA_replication0.76816168
96MP0005535_abnormal_body_temperature0.76678631
97MP0000858_altered_metastatic_potential0.76382195
98MP0005166_decreased_susceptibility_to0.76139291
99MP0003950_abnormal_plasma_membrane0.70442451
100MP0000920_abnormal_myelination0.65806498
101MP0004859_abnormal_synaptic_plasticity0.65765416
102MP0000249_abnormal_blood_vessel0.65521170
103MP0000569_abnormal_digit_pigmentation0.65396836
104MP0005266_abnormal_metabolism0.63931742
105MP0001663_abnormal_digestive_system0.63676642
106MP0000627_abnormal_mammary_gland0.63488980
107MP0001727_abnormal_embryo_implantation0.62159083
108MP0002972_abnormal_cardiac_muscle0.60967194
109MP0005595_abnormal_vascular_smooth0.58333679
110MP0003045_fibrosis0.57533330
111MP0010307_abnormal_tumor_latency0.55748189
112MP0000609_abnormal_liver_physiology0.54607599
113MP0000490_abnormal_crypts_of0.54567092
114MP0002163_abnormal_gland_morphology0.53770672
115MP0008995_early_reproductive_senescence0.51634385
116MP0001216_abnormal_epidermal_layer0.49627863
117MP0000367_abnormal_coat/_hair0.49391378
118MP0009765_abnormal_xenobiotic_induced0.47909268
119MP0008569_lethality_at_weaning0.47585821
120MP0004381_abnormal_hair_follicle0.43776101
121MP0003633_abnormal_nervous_system0.43750891
122MP0002136_abnormal_kidney_physiology0.43143707
123MP0002019_abnormal_tumor_incidence0.41688259
124MP0001243_abnormal_dermal_layer0.41323472
125MP0009763_increased_sensitivity_to0.39746207
126MP0004883_abnormal_blood_vessel0.38304525
127MP0002693_abnormal_pancreas_physiology0.37677242
128* MP0004742_abnormal_vestibular_system0.37206664

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)9.18910626
2Increased density of long bones (HP:0006392)6.14174654
3Eczematoid dermatitis (HP:0000976)5.52227624
4Persistence of primary teeth (HP:0006335)5.50790713
5Increased IgM level (HP:0003496)5.40959277
6Elevated erythrocyte sedimentation rate (HP:0003565)5.33683165
7Abnormality of liposaccharide metabolism (HP:0010968)5.18857180
8Abnormality of glycosphingolipid metabolism (HP:0004343)5.18857180
9Abnormality of glycolipid metabolism (HP:0010969)5.18857180
10Retrobulbar optic neuritis (HP:0100654)5.02686250
11Optic neuritis (HP:0100653)5.02686250
12Orchitis (HP:0100796)4.57146282
13Gastrointestinal infarctions (HP:0005244)4.50930229
14Myositis (HP:0100614)4.39360326
15Recurrent fungal infections (HP:0002841)4.08357585
16Abnormality of T cell number (HP:0011839)4.08183841
17T lymphocytopenia (HP:0005403)4.00010684
18Severe combined immunodeficiency (HP:0004430)3.95649242
19Abnormality of macrophages (HP:0004311)3.92102932
20Arterial thrombosis (HP:0004420)3.79255519
21Loss of speech (HP:0002371)3.78732905
22Mediastinal lymphadenopathy (HP:0100721)3.76143472
23Pulmonary infiltrates (HP:0002113)3.70283822
24IgA deficiency (HP:0002720)3.64433395
25Vasculitis (HP:0002633)3.63927113
26Systemic lupus erythematosus (HP:0002725)3.59898579
27Peripheral hypomyelination (HP:0007182)3.52148849
28IgG deficiency (HP:0004315)3.51432594
29Mutism (HP:0002300)3.46143137
30Abnormality of T cells (HP:0002843)3.44530216
31Vacuolated lymphocytes (HP:0001922)3.41088096
32Combined immunodeficiency (HP:0005387)3.39592179
33Disinhibition (HP:0000734)3.35729929
34Nasal polyposis (HP:0100582)3.32304744
35Keratoconjunctivitis sicca (HP:0001097)3.29547505
36Panhypogammaglobulinemia (HP:0003139)3.26446120
37Increased cerebral lipofuscin (HP:0011813)3.12305662
38B lymphocytopenia (HP:0010976)3.07923389
39Abnormality of B cell number (HP:0010975)3.07923389
40Dysostosis multiplex (HP:0000943)3.05891862
41Recurrent bronchitis (HP:0002837)3.04032338
42Recurrent viral infections (HP:0004429)2.99736857
43Keratoconjunctivitis (HP:0001096)2.97011359
44Chest pain (HP:0100749)2.93905785
45Hypergammaglobulinemia (HP:0010702)2.91392488
46Hemoptysis (HP:0002105)2.91190121
47Fatigue (HP:0012378)2.90860947
48Chronic otitis media (HP:0000389)2.90535216
49IgM deficiency (HP:0002850)2.89533195
50Abnormality of T cell physiology (HP:0011840)2.87049014
51Segmental peripheral demyelination/remyelination (HP:0003481)2.86350506
52Abnormality of the nasal mucosa (HP:0000433)2.76218766
53Leukocytosis (HP:0001974)2.73066873
54Asymmetric septal hypertrophy (HP:0001670)2.71488653
55Abnormality of mucopolysaccharide metabolism (HP:0011020)2.68370317
56Abnormality of polysaccharide metabolism (HP:0011012)2.68370317
57Abnormality of glycosaminoglycan metabolism (HP:0004371)2.68370317
58Premature loss of primary teeth (HP:0006323)2.66814664
59Abnormality of eosinophils (HP:0001879)2.65350244
60Myocardial infarction (HP:0001658)2.64406929
61Abnormal delayed hypersensitivity skin test (HP:0002963)2.61876302
62Gingivitis (HP:0000230)2.60599422
63Inflammation of the large intestine (HP:0002037)2.59968449
64Hematochezia (HP:0002573)2.57307551
65Increased IgE level (HP:0003212)2.56206131
66Autoimmune thrombocytopenia (HP:0001973)2.55627639
67Ulnar claw (HP:0001178)2.55384111
68Thyroiditis (HP:0100646)2.53127098
69Joint swelling (HP:0001386)2.49447004
70Polyneuropathy (HP:0001271)2.49254373
71Nuclear cataract (HP:0100018)2.48310124
72Autoimmune hemolytic anemia (HP:0001890)2.47975905
73Abnormality of the fingertips (HP:0001211)2.47829084
74Recurrent cutaneous fungal infections (HP:0011370)2.46702999
75Chronic mucocutaneous candidiasis (HP:0002728)2.46702999
76Urinary glycosaminoglycan excretion (HP:0003541)2.46006479
77Mucopolysacchariduria (HP:0008155)2.46006479
78Upper limb muscle weakness (HP:0003484)2.45415123
79Neurofibrillary tangles (HP:0002185)2.43697686
80Amyloidosis (HP:0011034)2.43281722
81Increased neuronal autofluorescent lipopigment (HP:0002074)2.41801621
82Chronic diarrhea (HP:0002028)2.39665005
83Gastrointestinal stroma tumor (HP:0100723)2.39584379
84Recurrent gram-negative bacterial infections (HP:0005420)2.39020554
85Alveolar cell carcinoma (HP:0006519)2.39017062
86Eosinophilia (HP:0001880)2.36540947
87Glomerulonephritis (HP:0000099)2.35388442
88Interstitial pulmonary disease (HP:0006530)2.34978002
89Gastrointestinal inflammation (HP:0004386)2.32852689
90Abnormality of binocular vision (HP:0011514)2.30795955
91Diplopia (HP:0000651)2.30795955
92Recurrent bacterial skin infections (HP:0005406)2.29880880
93Emphysema (HP:0002097)2.26565564
94Increased CSF protein (HP:0002922)2.26269380
95Pulmonary embolism (HP:0002204)2.25929744
96Neoplasm of the tracheobronchial system (HP:0100552)2.24452428
97Chronic obstructive pulmonary disease (HP:0006510)2.24009952
98Obstructive lung disease (HP:0006536)2.24009952
99Thrombocytosis (HP:0001894)2.23425918
100Amaurosis fugax (HP:0100576)2.21296251
101Axonal loss (HP:0003447)2.20706997
102Muscle fiber splitting (HP:0003555)2.19848524
103Abnormality of the endocardium (HP:0004306)2.18668196
104Recurrent abscess formation (HP:0002722)2.17239063
105Lymphopenia (HP:0001888)2.14920023
106Abnormality of cells of the lymphoid lineage (HP:0012140)2.14327957
107Peritonitis (HP:0002586)2.13857127
108Muscle fiber inclusion bodies (HP:0100299)2.12970310
109Gangrene (HP:0100758)2.12812562
110Meningitis (HP:0001287)2.12097687
111Increased serum ferritin (HP:0003281)2.11601474
112Episodic fever (HP:0001954)2.09921465
113Gingival bleeding (HP:0000225)2.09425014
114Anorexia (HP:0002039)2.08036046
115Nausea (HP:0002018)2.06715461
116Complement deficiency (HP:0004431)2.05773870
117Apathy (HP:0000741)2.05731160
118Abnormality of the pericardium (HP:0001697)2.03158466
119Abnormality of the nasal septum (HP:0000419)2.01403162
120Inappropriate behavior (HP:0000719)2.01010948
121Restrictive lung disease (HP:0002091)2.00114840
122Polycythemia (HP:0001901)1.96708649
123Parakeratosis (HP:0001036)1.96368747
124Acrocyanosis (HP:0001063)1.96367890
125Rhinitis (HP:0012384)1.95976143
126Basal ganglia calcification (HP:0002135)1.95940882
127Arthralgia (HP:0002829)1.94409330
128Diminished motivation (HP:0000745)1.92966937
129Vertigo (HP:0002321)1.92880127
130Neuronal loss in central nervous system (HP:0002529)1.92872587
131Recurrent skin infections (HP:0001581)1.91831901
132Spontaneous hematomas (HP:0007420)1.91553218
133Depressed nasal tip (HP:0000437)1.89247419
134Lymphoma (HP:0002665)1.89202353
135Hepatitis (HP:0012115)1.88520296
136Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.87909012
137Bilateral sensorineural hearing impairment (HP:0008619)1.85699511
138Thrombophlebitis (HP:0004418)1.83663444
139Pustule (HP:0200039)1.83324291
140Encephalitis (HP:0002383)1.82707103
141Abnormality of the pleura (HP:0002103)1.82190840
142Acute myeloid leukemia (HP:0004808)1.79457707
143* Somatic mutation (HP:0001428)1.79033574
144Osteomyelitis (HP:0002754)1.78480952
145Granulocytopenia (HP:0001913)1.77311183
146Cerebral ischemia (HP:0002637)1.77278707
147Nemaline bodies (HP:0003798)1.76495109
148Cellulitis (HP:0100658)1.75362436
149Acne (HP:0001061)1.73174759
150Porencephaly (HP:0002132)1.71935809

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.41175337
2MAP4K14.85147112
3MAP3K144.57059944
4IKBKB3.14070580
5CHUK2.94862119
6JAK32.92977345
7GRK72.64666880
8ZAP702.61939413
9TBK12.42407505
10PIM22.26173495
11IKBKE2.22008584
12ITK2.11783081
13DDR22.01285452
14EPHA32.00813907
15OBSCN1.90059791
16IRAK31.87303117
17TYK21.87281830
18EPHB11.86200605
19MATK1.74139913
20TAOK11.70356132
21JAK11.67097903
22NLK1.63857234
23PIM11.63234900
24TAOK31.60511911
25ADRBK21.54368768
26MAP3K111.49194257
27CDK121.49101122
28PDK21.48650595
29FGFR41.48421386
30EEF2K1.45384709
31MAP3K131.43855328
32TEC1.41107540
33MOS1.39986438
34FGFR31.39775820
35RPS6KA51.38708897
36MAP3K101.33471349
37HCK1.32762780
38TSSK61.32674034
39MAP2K31.26845894
40CDC42BPA1.25661068
41GRK61.25345305
42RPS6KA41.22228542
43LCK1.17304323
44IRAK21.15481575
45SYK1.14740337
46PRKAA21.12956023
47TAOK21.11646438
48MAPK71.11020765
49MAP3K31.09245381
50RIPK41.08150556
51BTK1.07154461
52MST41.03750990
53STK101.02555728
54KSR21.01003932
55EIF2AK31.00478446
56TTN0.98926156
57JAK20.98216013
58BMX0.96638477
59CSK0.92229386
60SIK30.91809727
61MAP3K70.91735209
62FGR0.88932324
63PRPF4B0.87322991
64MAP3K10.86999942
65NME20.86590708
66SIK20.86337298
67MAPK120.84034775
68RAF10.83017185
69ALK0.82192332
70PRKCQ0.81417393
71* RPS6KA10.76737596
72PKN10.75542488
73MAPK40.75169297
74CAMK1D0.74282234
75IRAK10.73328984
76LATS20.73251509
77AKT30.73178046
78PAK60.72946184
79MARK30.70009325
80GSK3A0.69205255
81BMPR20.68285713
82PDGFRB0.67588338
83IRAK40.64466722
84MAP3K50.64027488
85PRKCH0.64002422
86NTRK20.63414696
87FES0.62880712
88TRIB30.62557007
89KSR10.58613749
90TGFBR20.57129617
91DMPK0.55001024
92PDGFRA0.54204329
93STK240.53122327
94HIPK20.49672352
95SGK20.49513000
96ABL20.46818504
97BLK0.45933310
98STK110.45190292
99RPS6KL10.44483538
100RPS6KC10.44483538
101TRPM70.43672009
102MELK0.43563956
103ACVR1B0.43468639
104MARK10.43432972
105LYN0.42222378
106MAPKAPK20.41555201
107RET0.41203530
108RPS6KA60.40302417
109CDK90.40244359
110BRD40.39158799
111NEK90.38435901
112TYRO30.37609898
113PTK60.36506597
114MAP2K60.34965194
115ABL10.34692015
116MAPK80.34463469
117FGFR10.34232095
118DAPK20.33923694
119MAP3K90.33686105
120RIPK10.33610864
121MAPK30.33542093
122PDK10.33289343
123MAPK150.32408888
124SGK30.30661295
125ROCK20.30512137
126INSR0.30484502
127MARK20.29173838
128KIT0.27921737
129ERN10.25204737
130LRRK20.24784044
131EGFR0.22500868
132MAPK10.21410554
133SGK10.21390351
134CLK10.18957426
135RPS6KB10.18598264

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.71381952
2NF-kappa B signaling pathway_Homo sapiens_hsa040643.18898153
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.07504777
4T cell receptor signaling pathway_Homo sapiens_hsa046602.85075420
5Graft-versus-host disease_Homo sapiens_hsa053322.70155181
6Osteoclast differentiation_Homo sapiens_hsa043802.65096795
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.56450065
8Primary immunodeficiency_Homo sapiens_hsa053402.50782552
9Autoimmune thyroid disease_Homo sapiens_hsa053202.44314738
10Leishmaniasis_Homo sapiens_hsa051402.31148812
11Asthma_Homo sapiens_hsa053102.25747691
12Type I diabetes mellitus_Homo sapiens_hsa049402.22007923
13Measles_Homo sapiens_hsa051622.18573525
14TNF signaling pathway_Homo sapiens_hsa046682.09317575
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.99728299
16Toxoplasmosis_Homo sapiens_hsa051451.81330386
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.75814307
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.74408013
19Prolactin signaling pathway_Homo sapiens_hsa049171.74182610
20B cell receptor signaling pathway_Homo sapiens_hsa046621.64860360
21Acute myeloid leukemia_Homo sapiens_hsa052211.64800386
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.63624870
23Legionellosis_Homo sapiens_hsa051341.57137455
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.50593608
25Hepatitis B_Homo sapiens_hsa051611.49377500
26AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.43645410
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42330558
28Viral myocarditis_Homo sapiens_hsa054161.35509452
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.33416797
30Influenza A_Homo sapiens_hsa051641.33274865
31Lysosome_Homo sapiens_hsa041421.31734864
32Chemokine signaling pathway_Homo sapiens_hsa040621.30780972
33Herpes simplex infection_Homo sapiens_hsa051681.30130141
34Chronic myeloid leukemia_Homo sapiens_hsa052201.28914089
35Other glycan degradation_Homo sapiens_hsa005111.26959027
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26619806
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21958947
38Apoptosis_Homo sapiens_hsa042101.19844879
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18747237
40Malaria_Homo sapiens_hsa051441.18551755
41Antigen processing and presentation_Homo sapiens_hsa046121.15173887
42Rheumatoid arthritis_Homo sapiens_hsa053231.13037586
43MAPK signaling pathway_Homo sapiens_hsa040101.11560017
44Tuberculosis_Homo sapiens_hsa051521.06128829
45Pertussis_Homo sapiens_hsa051331.05655529
46Shigellosis_Homo sapiens_hsa051311.05524934
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.05106436
48Adipocytokine signaling pathway_Homo sapiens_hsa049201.00585708
49HTLV-I infection_Homo sapiens_hsa051660.97272099
50Salmonella infection_Homo sapiens_hsa051320.96755238
51Hematopoietic cell lineage_Homo sapiens_hsa046400.94749234
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.89933697
53Pancreatic cancer_Homo sapiens_hsa052120.89270648
54Hepatitis C_Homo sapiens_hsa051600.88185766
55Circadian rhythm_Homo sapiens_hsa047100.86092981
56African trypanosomiasis_Homo sapiens_hsa051430.85622154
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84221790
58Type II diabetes mellitus_Homo sapiens_hsa049300.82666451
59Epstein-Barr virus infection_Homo sapiens_hsa051690.81190370
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80798440
61VEGF signaling pathway_Homo sapiens_hsa043700.80000367
62Viral carcinogenesis_Homo sapiens_hsa052030.76674152
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74892581
64Small cell lung cancer_Homo sapiens_hsa052220.73312115
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72827847
66* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72581499
67Bladder cancer_Homo sapiens_hsa052190.71324003
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70529721
69Phagosome_Homo sapiens_hsa041450.69674199
70Colorectal cancer_Homo sapiens_hsa052100.65475802
71Complement and coagulation cascades_Homo sapiens_hsa046100.62198721
72ErbB signaling pathway_Homo sapiens_hsa040120.61629796
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60285377
74Cocaine addiction_Homo sapiens_hsa050300.59150601
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.58543944
76Insulin resistance_Homo sapiens_hsa049310.58129423
77FoxO signaling pathway_Homo sapiens_hsa040680.56849522
78Prion diseases_Homo sapiens_hsa050200.55025945
79Platelet activation_Homo sapiens_hsa046110.54411974
80Amoebiasis_Homo sapiens_hsa051460.53792431
81Renal cell carcinoma_Homo sapiens_hsa052110.52959794
82Mineral absorption_Homo sapiens_hsa049780.50315838
83Dorso-ventral axis formation_Homo sapiens_hsa043200.49989929
84Ovarian steroidogenesis_Homo sapiens_hsa049130.49342157
85MicroRNAs in cancer_Homo sapiens_hsa052060.48712583
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.47994261
87HIF-1 signaling pathway_Homo sapiens_hsa040660.44465903
88Prostate cancer_Homo sapiens_hsa052150.43306532
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42513002
90mTOR signaling pathway_Homo sapiens_hsa041500.41952720
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40475247
92Endometrial cancer_Homo sapiens_hsa052130.39027508
93Sphingolipid metabolism_Homo sapiens_hsa006000.37604844
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35150575
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34947718
96Endocytosis_Homo sapiens_hsa041440.34922282
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34653484
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33877114
99Estrogen signaling pathway_Homo sapiens_hsa049150.33035854
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32614378
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32006578
102Long-term potentiation_Homo sapiens_hsa047200.31465792
103GnRH signaling pathway_Homo sapiens_hsa049120.31434486
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30362838
105Renin secretion_Homo sapiens_hsa049240.30219257
106Non-small cell lung cancer_Homo sapiens_hsa052230.30102578
107cAMP signaling pathway_Homo sapiens_hsa040240.29650546
108Ras signaling pathway_Homo sapiens_hsa040140.29459220
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28930295
110Notch signaling pathway_Homo sapiens_hsa043300.27111420
111Cholinergic synapse_Homo sapiens_hsa047250.26315648
112Pathways in cancer_Homo sapiens_hsa052000.26053505
113Staphylococcus aureus infection_Homo sapiens_hsa051500.25854891
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.25143852
115Proteoglycans in cancer_Homo sapiens_hsa052050.25058912
116Oxytocin signaling pathway_Homo sapiens_hsa049210.24268073
117Fatty acid biosynthesis_Homo sapiens_hsa000610.22617548
118Collecting duct acid secretion_Homo sapiens_hsa049660.21163634
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.18589472
120Insulin signaling pathway_Homo sapiens_hsa049100.16754091
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.16289601

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