NR5A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glucocorticoid metabolic process (GO:0008211)9.60148676
2cellular response to cadmium ion (GO:0071276)9.15277795
3C21-steroid hormone metabolic process (GO:0008207)8.73276782
4progesterone metabolic process (GO:0042448)7.82573729
5response to follicle-stimulating hormone (GO:0032354)7.65594183
6* sex determination (GO:0007530)7.40602828
7androgen metabolic process (GO:0008209)7.37258658
8hormone biosynthetic process (GO:0042446)7.10747402
9ketone biosynthetic process (GO:0042181)7.08387086
10cellular response to interferon-alpha (GO:0035457)6.96398145
11regulation of gonadotropin secretion (GO:0032276)6.95527097
12Leydig cell differentiation (GO:0033327)6.80656002
13estrogen metabolic process (GO:0008210)6.57213369
14cellular response to gonadotropin stimulus (GO:0071371)6.56070625
15sex differentiation (GO:0007548)6.31226909
16very-low-density lipoprotein particle assembly (GO:0034379)6.28368543
17cellular response to antibiotic (GO:0071236)6.08368012
18plasma lipoprotein particle assembly (GO:0034377)5.94728476
19positive regulation of hormone metabolic process (GO:0032352)5.86027181
20cholesterol efflux (GO:0033344)5.82859581
21high-density lipoprotein particle remodeling (GO:0034375)5.70295028
22intestinal cholesterol absorption (GO:0030299)5.51636085
23reverse cholesterol transport (GO:0043691)5.43423125
24plasma lipoprotein particle clearance (GO:0034381)5.43400213
25protein-lipid complex assembly (GO:0065005)5.30802109
26protein-lipid complex remodeling (GO:0034368)5.26593391
27macromolecular complex remodeling (GO:0034367)5.26593391
28plasma lipoprotein particle remodeling (GO:0034369)5.26593391
29low-density lipoprotein particle remodeling (GO:0034374)5.23263708
30regulation of cholesterol biosynthetic process (GO:0045540)5.22967681
31anatomical structure regression (GO:0060033)5.21735771
32adhesion of symbiont to host (GO:0044406)5.21032240
33regulation of apoptotic cell clearance (GO:2000425)5.20232047
34plasma lipoprotein particle organization (GO:0071827)5.17232267
35regulation of cholesterol homeostasis (GO:2000188)5.12801800
36mating behavior (GO:0007617)4.89512191
37protein-lipid complex subunit organization (GO:0071825)4.87060080
38regulation of complement activation (GO:0030449)4.72291503
39* positive regulation of male gonad development (GO:2000020)4.70336317
40cellular response to growth hormone stimulus (GO:0071378)4.70196880
41regulation of cholesterol esterification (GO:0010872)4.70036906
42response to gonadotropin (GO:0034698)4.65450634
43regulation of protein activation cascade (GO:2000257)4.64439062
44sterol transport (GO:0015918)4.59798850
45cholesterol transport (GO:0030301)4.59798850
46response to leptin (GO:0044321)4.48307283
47negative regulation of fibrinolysis (GO:0051918)4.46630203
48regulation of meiosis I (GO:0060631)4.45340795
49positive regulation of steroid metabolic process (GO:0045940)4.44911261
50* regulation of male gonad development (GO:2000018)4.44708155
51negative regulation of macrophage differentiation (GO:0045650)4.39958347
52cellular response to toxic substance (GO:0097237)4.38476357
53male sex determination (GO:0030238)4.35990074
54oocyte development (GO:0048599)4.34667062
55response to methylmercury (GO:0051597)4.30756899
56positive regulation of steroid biosynthetic process (GO:0010893)4.30555327
57cellular response to zinc ion (GO:0071294)4.29209767
58sterol metabolic process (GO:0016125)4.21233387
59piRNA metabolic process (GO:0034587)4.19218176
60response to insecticide (GO:0017085)4.18074028
61fusion of sperm to egg plasma membrane (GO:0007342)4.16796598
62triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.12710327
63male genitalia development (GO:0030539)3.90441451
64cholesterol metabolic process (GO:0008203)3.82327746
65regulation of cholesterol metabolic process (GO:0090181)3.81145991
66response to lead ion (GO:0010288)3.79842589
67protein carboxylation (GO:0018214)3.79266137
68peptidyl-glutamic acid carboxylation (GO:0017187)3.79266137
69hemoglobin metabolic process (GO:0020027)3.74211667
70seminiferous tubule development (GO:0072520)3.73201074
71regulation of fibrinolysis (GO:0051917)3.65158810
72lipoprotein metabolic process (GO:0042157)3.65054755
73renal system process involved in regulation of blood volume (GO:0001977)3.60417748
74benzene-containing compound metabolic process (GO:0042537)3.59756872
75glomerular basement membrane development (GO:0032836)3.55976134
76synaptonemal complex assembly (GO:0007130)3.55450792
77complement activation, alternative pathway (GO:0006957)3.50588393
78detection of molecule of bacterial origin (GO:0032490)3.49813348
79intestinal absorption (GO:0050892)3.48315222
80low-density lipoprotein particle clearance (GO:0034383)3.46499948
81receptor guanylyl cyclase signaling pathway (GO:0007168)3.41404046
82response to mineralocorticoid (GO:0051385)3.41279932
83cholesterol homeostasis (GO:0042632)3.37138929
84synaptonemal complex organization (GO:0070193)3.36050346
85cellular hormone metabolic process (GO:0034754)3.35266916
86* regulation of steroid biosynthetic process (GO:0050810)3.33136651
87sterol homeostasis (GO:0055092)3.32814981
88regulation of plasminogen activation (GO:0010755)3.30016182
89phospholipid efflux (GO:0033700)3.29712298
90cellular response to epinephrine stimulus (GO:0071872)3.27928223
91negative regulation of sterol transport (GO:0032372)3.25606217
92negative regulation of cholesterol transport (GO:0032375)3.25606217
93regulation of triglyceride biosynthetic process (GO:0010866)3.24775824
94regulation of bile acid biosynthetic process (GO:0070857)3.23906660
95ovulation cycle (GO:0042698)3.22973033
96regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.22607916
97toxin metabolic process (GO:0009404)3.15555310
98positive regulation of fatty acid biosynthetic process (GO:0045723)3.15372068
99urogenital system development (GO:0001655)3.14881886
100protein heterotrimerization (GO:0070208)3.13804663
101plasma membrane fusion (GO:0045026)3.12985452
102cellular ketone metabolic process (GO:0042180)3.10317478
103renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.04942890
104blood coagulation, intrinsic pathway (GO:0007597)3.03887050
105chondrocyte proliferation (GO:0035988)3.01897292
106ovulation (GO:0030728)3.00883547
107reproductive system development (GO:0061458)2.99909460
108embryonic foregut morphogenesis (GO:0048617)2.96853557
109positive regulation of lipid storage (GO:0010884)2.95061757
110phagocytosis, recognition (GO:0006910)2.94222120
111male meiosis (GO:0007140)2.91956591
112positive regulation of lipid biosynthetic process (GO:0046889)2.91487411
113sterol catabolic process (GO:0016127)2.91225772
114cholesterol catabolic process (GO:0006707)2.91225772
115cholesterol biosynthetic process (GO:0006695)2.90706846
116regulation of hormone biosynthetic process (GO:0046885)2.89045890
117steroid biosynthetic process (GO:0006694)2.88805010
118positive regulation of nitric-oxide synthase activity (GO:0051000)2.79942895
119DNA methylation involved in gamete generation (GO:0043046)2.78019102
120apoptotic cell clearance (GO:0043277)2.74760969
121alpha-linolenic acid metabolic process (GO:0036109)2.69868160
122intracellular lipid transport (GO:0032365)2.69611342
123macroautophagy (GO:0016236)2.66146271
124positive regulation of hormone biosynthetic process (GO:0046886)2.64599653
125genitalia development (GO:0048806)2.64147165
126nephron tubule formation (GO:0072079)2.63206043
127negative regulation of cytosolic calcium ion concentration (GO:0051481)2.62075716
128positive regulation of triglyceride biosynthetic process (GO:0010867)2.58606078
129response to interferon-alpha (GO:0035455)2.58017624
130response to epinephrine (GO:0071871)2.55592453
131positive regulation of meiosis (GO:0045836)2.53878376
132cytokine metabolic process (GO:0042107)2.50914378
133response to cadmium ion (GO:0046686)2.50551311
134peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.49661326
135growth hormone secretion (GO:0030252)2.48628724
136potassium ion homeostasis (GO:0055075)2.45784577
137basement membrane organization (GO:0071711)2.39837370
138ovarian follicle development (GO:0001541)2.37069327
139response to corticosterone (GO:0051412)2.34955466
140response to phenylpropanoid (GO:0080184)2.34771961
141* male gonad development (GO:0008584)2.34486427
142NADP metabolic process (GO:0006739)2.33373108
143positive regulation of meiotic cell cycle (GO:0051446)2.30147595
144regulation of cardioblast differentiation (GO:0051890)2.30073204
145regulation of cholesterol storage (GO:0010885)2.29580774
146* positive regulation of reproductive process (GO:2000243)2.29452106
147linoleic acid metabolic process (GO:0043651)2.29309815
148astrocyte development (GO:0014002)2.28971320
149regulation of steroid hormone biosynthetic process (GO:0090030)2.27007133
150female gonad development (GO:0008585)2.26414638
151* ovulation cycle process (GO:0022602)2.26183064
152vitamin D metabolic process (GO:0042359)2.24915424
153cGMP biosynthetic process (GO:0006182)2.24393985
154gonadal mesoderm development (GO:0007506)19.4662590
155androgen biosynthetic process (GO:0006702)14.3065088
156estrogen biosynthetic process (GO:0006703)13.9855342
157C21-steroid hormone biosynthetic process (GO:0006700)12.6982857
158glucocorticoid biosynthetic process (GO:0006704)12.2561697
159cellular response to follicle-stimulating hormone stimulus (GO:0071372)10.2080151

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.73890255
2STAT6_21828071_ChIP-Seq_BEAS2B_Human5.90371249
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.56942360
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.27542358
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.25075560
6CLOCK_20551151_ChIP-Seq_293T_Human4.24416656
7LXR_22158963_ChIP-Seq_LIVER_Mouse4.15988755
8PPARA_22158963_ChIP-Seq_LIVER_Mouse3.87462165
9IKZF1_21737484_ChIP-ChIP_HCT116_Human3.66192089
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.24220489
11ESR1_15608294_ChIP-ChIP_MCF-7_Human3.17283745
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.08973349
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.01638693
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.98130727
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.84475111
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.83582663
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.74170298
18WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.72681646
19ZNF263_19887448_ChIP-Seq_K562_Human2.62176859
20* HNF4A_19822575_ChIP-Seq_HepG2_Human2.54661705
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.52159938
22TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.48439996
23ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.44160253
24HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.39523540
25ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.38958139
26ZFP281_18757296_ChIP-ChIP_E14_Mouse2.36388232
27RBPJ_22232070_ChIP-Seq_NCS_Mouse2.20479507
28DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.16285445
29FOXM1_23109430_ChIP-Seq_U2OS_Human2.15347776
30KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.09579222
31KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.09579222
32KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.09579222
33RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08196141
34KDM2B_26808549_Chip-Seq_DND41_Human2.03868029
35HIF1A_21447827_ChIP-Seq_MCF-7_Human2.03107468
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.02703722
37CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.98380628
38EGR1_23403033_ChIP-Seq_LIVER_Mouse1.98080523
39HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.87306661
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.81727310
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80754703
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.77477860
43* KDM2B_26808549_Chip-Seq_K562_Human1.71518968
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68233982
45CDX2_20551321_ChIP-Seq_CACO-2_Human1.68105251
46ZFP281_27345836_Chip-Seq_ESCs_Mouse1.65195094
47SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.65027720
48RUNX1_27514584_Chip-Seq_MCF-7_Human1.62370744
49TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60826010
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.60127229
51CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.59064261
52ESR1_21235772_ChIP-Seq_MCF-7_Human1.58051013
53GATA4_25053715_ChIP-Seq_YYC3_Human1.54376383
54ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.51058941
55RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.48448978
56P300_27058665_Chip-Seq_ZR-75-30cells_Human1.48110732
57TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.47110999
58ISL1_27105846_Chip-Seq_CPCs_Mouse1.46964002
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46921066
60NFIB_24661679_ChIP-Seq_LUNG_Mouse1.46687255
61ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46492464
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46120297
63TCF7_22412390_ChIP-Seq_EML_Mouse1.44691593
64* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43592416
65CREB1_26743006_Chip-Seq_LNCaP_Human1.43368085
66TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41336237
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.40284800
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.40050546
69FOXO3_23340844_ChIP-Seq_DLD1_Human1.39903406
70TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39144647
71GATA1_26923725_Chip-Seq_HPCs_Mouse1.38526607
72ESR1_20079471_ChIP-ChIP_T-47D_Human1.35038126
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33463332
74TP53_22127205_ChIP-Seq_IMR90_Human1.31197990
75* LXR_22292898_ChIP-Seq_THP-1_Human1.30353864
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.29181222
77* GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.28970834
78AR_21572438_ChIP-Seq_LNCaP_Human1.28170895
79TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.27266826
80RACK7_27058665_Chip-Seq_MCF-7_Human1.26148956
81GATA6_25053715_ChIP-Seq_YYC3_Human1.25929409
82KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25355376
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.24938373
84KDM2B_26808549_Chip-Seq_JURKAT_Human1.21644571
85FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.21296740
86TCF4_18268006_ChIP-ChIP_LS174T_Human1.20612016
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17788904
88ELK3_25401928_ChIP-Seq_HUVEC_Human1.17303128
89WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17231568
90SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16758822
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16158805
92CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14945519
93SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.14064131
94CHD1_26751641_Chip-Seq_LNCaP_Human1.13091121
95SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10787219
96FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.10716345
97ERG_21242973_ChIP-ChIP_JURKAT_Human1.08417311
98* NCOR1_26117541_ChIP-Seq_K562_Human1.07833689
99* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.06854212
100* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.06854212
101CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06677259
102PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06538193
103* TBX20_22328084_ChIP-Seq_HEART_Mouse1.05624110
104* TBX20_22080862_ChIP-Seq_HEART_Mouse1.05624110
105TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04238688
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01888220
107CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01521389
108SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00944192
109EP300_21415370_ChIP-Seq_HL-1_Mouse1.00109702
110PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00066838
111SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99304169
112ZNF274_21170338_ChIP-Seq_K562_Hela0.98397537
113ATF3_27146783_Chip-Seq_COLON_Human0.98277627
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96867070
115CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96569082
116* SMAD4_21741376_ChIP-Seq_EPCs_Human0.96396211
117POU5F1_16518401_ChIP-PET_MESCs_Mouse0.96389692
118TRIM28_21343339_ChIP-Seq_HEK293_Human0.94778213
119FOXA2_19822575_ChIP-Seq_HepG2_Human0.94105842
120GATA1_19941826_ChIP-Seq_K562_Human0.92264226
121CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92240275
122* RNF2_27304074_Chip-Seq_ESCs_Mouse0.91654180
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91610107
124NANOG_21062744_ChIP-ChIP_HESCs_Human0.91540783
125SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91386387
126* STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.89043656
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88948596
128PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88850158
129ELK4_26923725_Chip-Seq_MESODERM_Mouse0.88189737
130* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88162812
131SALL1_21062744_ChIP-ChIP_HESCs_Human0.86818925
132BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86064655
133KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86056587
134SA1_27219007_Chip-Seq_ERYTHROID_Human0.86003901
135KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.85633700
136OCT4_19829295_ChIP-Seq_ESCs_Human0.85419170
137DNAJC2_21179169_ChIP-ChIP_NT2_Human0.84547296
138KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.83383626
139PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.83122662
140NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.82794549
141* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.82547947
142CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81834425
143RAD21_21589869_ChIP-Seq_MESCs_Mouse0.80961369
144RXRA_24833708_ChIP-Seq_LIVER_Mouse0.80129003
145NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.77672576
146GATA1_19941827_ChIP-Seq_MEL_Mouse0.77248075
147GATA2_21666600_ChIP-Seq_HMVEC_Human0.75502417
148RARA_24833708_ChIP-Seq_LIVER_Mouse0.74694877
149ESET_19884257_ChIP-Seq_ESCs_Mouse0.74071203
150UBF1/2_26484160_Chip-Seq_HMECs_Human0.74025644
151ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.74006705
152ESR2_21235772_ChIP-Seq_MCF-7_Human0.73894513
153JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.71317052
154GATA2_19941826_ChIP-Seq_K562_Human0.69163047
155SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.68408933
156RARB_24833708_ChIP-Seq_LIVER_Mouse0.67409458
157Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.65970617

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence7.21138019
2MP0010368_abnormal_lymphatic_system4.52388597
3MP0008877_abnormal_DNA_methylation3.87517240
4MP0002909_abnormal_adrenal_gland3.78235800
5* MP0000639_abnormal_adrenal_gland3.78127575
6MP0008875_abnormal_xenobiotic_pharmacok3.69928034
7MP0009840_abnormal_foam_cell3.68578767
8MP0005377_hearing/vestibular/ear_phenot3.62301899
9MP0003878_abnormal_ear_physiology3.62301899
10MP0005360_urolithiasis3.62076446
11MP0005647_abnormal_sex_gland3.40409081
12MP0010329_abnormal_lipoprotein_level3.31356854
13MP0003315_abnormal_perineum_morphology3.29242135
14MP0005365_abnormal_bile_salt3.18409605
15MP0001661_extended_life_span3.17479851
16MP0003195_calcinosis2.82617637
17MP0003786_premature_aging2.58057802
18MP0002139_abnormal_hepatobiliary_system2.57602124
19MP0008004_abnormal_stomach_pH2.55721496
20MP0003123_paternal_imprinting2.38203738
21* MP0002210_abnormal_sex_determination2.35537501
22MP0009384_cardiac_valve_regurgitation2.25996225
23MP0003011_delayed_dark_adaptation2.25948654
24* MP0001145_abnormal_male_reproductive2.12679885
25MP0005623_abnormal_meninges_morphology2.12577425
26MP0004272_abnormal_basement_membrane2.09680857
27MP0000566_synostosis2.02288029
28MP0005410_abnormal_fertilization2.01791386
29MP0001666_abnormal_nutrient_absorption1.99840947
30* MP0001929_abnormal_gametogenesis1.99320391
31MP0009278_abnormal_bone_marrow1.96256866
32MP0000751_myopathy1.90926728
33MP0001958_emphysema1.90837792
34MP0003941_abnormal_skin_development1.89056728
35MP0004084_abnormal_cardiac_muscle1.88508836
36MP0008438_abnormal_cutaneous_collagen1.86045293
37MP0003045_fibrosis1.85103948
38MP0002089_abnormal_postnatal_growth/wei1.82674138
39* MP0000653_abnormal_sex_gland1.81149811
40MP0003172_abnormal_lysosome_physiology1.80940857
41MP0005058_abnormal_lysosome_morphology1.78357033
42MP0003115_abnormal_respiratory_system1.77472290
43MP0005187_abnormal_penis_morphology1.68523459
44MP0001915_intracranial_hemorrhage1.63992862
45MP0003329_amyloid_beta_deposits1.62632179
46MP0005085_abnormal_gallbladder_physiolo1.60556294
47MP0005503_abnormal_tendon_morphology1.57923954
48MP0003942_abnormal_urinary_system1.56996692
49MP0005083_abnormal_biliary_tract1.53249689
50* MP0003698_abnormal_male_reproductive1.53116507
51MP0003122_maternal_imprinting1.49173157
52MP0003300_gastrointestinal_ulcer1.46172329
53MP0003936_abnormal_reproductive_system1.45141859
54MP0000609_abnormal_liver_physiology1.41397111
55MP0002118_abnormal_lipid_homeostasis1.40535091
56MP0001765_abnormal_ion_homeostasis1.39458492
57MP0003283_abnormal_digestive_organ1.39302867
58MP0001919_abnormal_reproductive_system1.38299145
59MP0002168_other_aberrant_phenotype1.35072722
60MP0003121_genomic_imprinting1.34425733
61MP0006138_congestive_heart_failure1.31408184
62MP0000537_abnormal_urethra_morphology1.31387888
63MP0000604_amyloidosis1.29634588
64MP0005451_abnormal_body_composition1.29424065
65MP0005379_endocrine/exocrine_gland_phen1.27913936
66MP0004019_abnormal_vitamin_homeostasis1.27068241
67MP0003705_abnormal_hypodermis_morpholog1.26379699
68MP0001727_abnormal_embryo_implantation1.24904706
69MP0003879_abnormal_hair_cell1.23817750
70MP0005076_abnormal_cell_differentiation1.21278254
71MP0005167_abnormal_blood-brain_barrier1.17953580
72MP0004036_abnormal_muscle_relaxation1.14405004
73MP0009780_abnormal_chondrocyte_physiolo1.12933815
74* MP0001119_abnormal_female_reproductive1.11594921
75MP0003119_abnormal_digestive_system1.06702238
76MP0002938_white_spotting1.06351544
77MP0004147_increased_porphyrin_level1.05900485
78* MP0000631_abnormal_neuroendocrine_gland1.01860720
79MP0005257_abnormal_intraocular_pressure1.00604118
80MP0003091_abnormal_cell_migration1.00484940
81MP0009053_abnormal_anal_canal0.99973103
82MP0003950_abnormal_plasma_membrane0.99112251
83MP0005332_abnormal_amino_acid0.98991054
84MP0005409_darkened_coat_color0.98689639
85MP0004145_abnormal_muscle_electrophysio0.98657558
86MP0002102_abnormal_ear_morphology0.98600067
87MP0002933_joint_inflammation0.96853148
88* MP0002161_abnormal_fertility/fecundity0.95481395
89MP0000230_abnormal_systemic_arterial0.94754431
90MP0003567_abnormal_fetal_cardiomyocyte0.94442408
91MP0004197_abnormal_fetal_growth/weight/0.92677735
92MP0000598_abnormal_liver_morphology0.92609713
93MP0004233_abnormal_muscle_weight0.88842998
94MP0001440_abnormal_grooming_behavior0.88219328
95MP0002269_muscular_atrophy0.88211185
96MP0000013_abnormal_adipose_tissue0.88145212
97MP0003385_abnormal_body_wall0.87060054
98MP0003191_abnormal_cellular_cholesterol0.86092937
99MP0000428_abnormal_craniofacial_morphol0.85754352
100MP0003787_abnormal_imprinting0.85176442
101* MP0005389_reproductive_system_phenotype0.84635415
102* MP0003953_abnormal_hormone_level0.83675317
103MP0006054_spinal_hemorrhage0.82685190
104MP0002132_abnormal_respiratory_system0.79578070
105MP0001984_abnormal_olfaction0.78634097
106MP0003566_abnormal_cell_adhesion0.78465057
107MP0003868_abnormal_feces_composition0.78021077
108MP0004883_abnormal_blood_vessel0.77324374
109MP0003632_abnormal_nervous_system0.76223535
110MP0000534_abnormal_ureter_morphology0.75820624
111MP0005248_abnormal_Harderian_gland0.75064297
112* MP0009642_abnormal_blood_homeostasis0.74313251
113MP0002092_abnormal_eye_morphology0.74264784
114MP0010630_abnormal_cardiac_muscle0.74054010
115MP0005408_hypopigmentation0.70911028
116* MP0003699_abnormal_female_reproductive0.70541309
117MP0004134_abnormal_chest_morphology0.69808521
118MP0005334_abnormal_fat_pad0.69271724
119MP0008961_abnormal_basal_metabolism0.68617689
120MP0002084_abnormal_developmental_patter0.68042332
121MP0003943_abnormal_hepatobiliary_system0.67570506
122MP0003935_abnormal_craniofacial_develop0.65791055
123MP0005636_abnormal_mineral_homeostasis0.65505237
124MP0005171_absent_coat_pigmentation0.64938742
125MP0000569_abnormal_digit_pigmentation0.64761237
126MP0003638_abnormal_response/metabolism_0.64504477
127MP0005164_abnormal_response_to0.63886046
128MP0004264_abnormal_extraembryonic_tissu0.63701487
129MP0004087_abnormal_muscle_fiber0.63587003
130MP0000003_abnormal_adipose_tissue0.63246748
131MP0009379_abnormal_foot_pigmentation0.63206954
132MP0002896_abnormal_bone_mineralization0.62792481
133MP0001340_abnormal_eyelid_morphology0.61693681
134MP0001324_abnormal_eye_pigmentation0.61498947
135MP0002009_preneoplasia0.59441889
136MP0001756_abnormal_urination0.59143298
137MP0000767_abnormal_smooth_muscle0.58832316
138MP0009672_abnormal_birth_weight0.58382987
139MP0000462_abnormal_digestive_system0.57331682
140MP0004858_abnormal_nervous_system0.57227154
141MP0005319_abnormal_enzyme/_coenzyme0.56076778
142MP0002295_abnormal_pulmonary_circulatio0.55693619
143MP0000266_abnormal_heart_morphology0.55438720
144MP0003252_abnormal_bile_duct0.54792294
145MP0005448_abnormal_energy_balance0.54557304
146MP0001851_eye_inflammation0.54553591
147MP0001270_distended_abdomen0.54473971
148MP0002998_abnormal_bone_remodeling0.54156856
149MP0009703_decreased_birth_body0.52536725
150MP0001730_embryonic_growth_arrest0.51795758
151MP0002108_abnormal_muscle_morphology0.51775544
152MP0005220_abnormal_exocrine_pancreas0.51698828
153MP0002282_abnormal_trachea_morphology0.51615297
154MP0002115_abnormal_skeleton_extremities0.50387566
155MP0003890_abnormal_embryonic-extraembry0.50009441
156MP0003221_abnormal_cardiomyocyte_apopto0.49961655
157MP0002127_abnormal_cardiovascular_syste0.49651248
158MP0003690_abnormal_glial_cell0.48748488
159MP0005395_other_phenotype0.48327843
160MP0000647_abnormal_sebaceous_gland0.48196945
161MP0005330_cardiomyopathy0.47534124
162MP0002233_abnormal_nose_morphology0.47252632
163MP0003183_abnormal_peptide_metabolism0.47183923
164MP0002078_abnormal_glucose_homeostasis0.46988599

Predicted human phenotypes

RankGene SetZ-score
1Abnormal sex determination (HP:0012244)9.40263406
2Sex reversal (HP:0012245)9.40263406
3Male infertility (HP:0003251)8.66572325
4Gonadotropin excess (HP:0000837)8.30472742
5Renal salt wasting (HP:0000127)6.87627121
6Deep venous thrombosis (HP:0002625)6.81128442
7Enlarged penis (HP:0000040)6.41357544
8* Gonadal dysgenesis (HP:0000133)6.25083094
9Hypoplasia of the uterus (HP:0000013)6.23942872
10Complement deficiency (HP:0004431)5.59751950
11* Male pseudohermaphroditism (HP:0000037)5.53417154
12Abnormality of carpal bone ossification (HP:0006257)4.70460044
13Aplasia/hypoplasia of the uterus (HP:0008684)4.67185173
14Ankle contracture (HP:0006466)4.51725631
15Prolonged partial thromboplastin time (HP:0003645)4.46479932
16Abnormality of complement system (HP:0005339)4.42069951
17Joint hemorrhage (HP:0005261)4.40227468
18Infertility (HP:0000789)4.34941801
19Xanthomatosis (HP:0000991)4.32940493
20Decreased circulating renin level (HP:0003351)4.14421111
21Hyperaldosteronism (HP:0000859)4.10931113
22Glomerulonephritis (HP:0000099)4.05525924
23Abnormality of male internal genitalia (HP:0000022)3.95968183
24Rectal prolapse (HP:0002035)3.75340696
25Abnormal ossification of hand bones (HP:0005921)3.60230323
26Abnormal hand bone ossification (HP:0010660)3.56118889
27* Testicular neoplasm (HP:0010788)3.55232732
28Hyperpituitarism (HP:0010514)3.52157958
29Epidermoid cyst (HP:0200040)3.52150452
30Systemic lupus erythematosus (HP:0002725)3.36618138
31Abnormality of renin-angiotensin system (HP:0000847)3.33775779
32Small epiphyses (HP:0010585)3.31856627
33Hypercholesterolemia (HP:0003124)3.25993010
34Cupped ribs (HP:0000887)3.18224834
35Protrusio acetabuli (HP:0003179)3.17951557
36Flared iliac wings (HP:0002869)3.17456258
37Orthostatic hypotension (HP:0001278)3.13259020
38Increased circulating renin level (HP:0000848)3.13099567
39Abnormality of the common coagulation pathway (HP:0010990)3.12458979
40Hypobetalipoproteinemia (HP:0003563)3.08667375
41Lymphangioma (HP:0100764)3.08262708
42Germ cell neoplasia (HP:0100728)3.02189499
43Hemorrhage of the eye (HP:0011885)3.01583024
44Broad palm (HP:0001169)3.01243664
45Mitral stenosis (HP:0001718)3.00864082
46Flat acetabular roof (HP:0003180)2.91282244
47Bladder diverticulum (HP:0000015)2.86449031
48Hypoventilation (HP:0002791)2.74246683
49Hypokalemic alkalosis (HP:0001949)2.74103884
50Abnormal tarsal ossification (HP:0008369)2.71295247
51Clitoromegaly (HP:0000057)2.70167836
52Neonatal onset (HP:0003623)2.68534330
53Recurrent gram-negative bacterial infections (HP:0005420)2.67961468
54Hand muscle atrophy (HP:0009130)2.61203241
55Macroorchidism (HP:0000053)2.60016736
56Mesangial abnormality (HP:0001966)2.55410294
57Diastasis recti (HP:0001540)2.54061542
58Menorrhagia (HP:0000132)2.53759692
59Adrenal overactivity (HP:0002717)2.52776612
60Skin nodule (HP:0200036)2.51178220
61Hypoplastic left heart (HP:0004383)2.50285004
62Abnormality of the alveolar ridges (HP:0006477)2.48961645
63Renovascular hypertension (HP:0100817)2.47854161
64Relative macrocephaly (HP:0004482)2.46233535
65Asymmetry of the thorax (HP:0001555)2.45436697
66Cerebral aneurysm (HP:0004944)2.44990469
67Vaginal fistula (HP:0004320)2.44703419
68Hypoplasia of the capital femoral epiphysis (HP:0003090)2.44670000
69Follicular hyperkeratosis (HP:0007502)2.44517493
70Urinary glycosaminoglycan excretion (HP:0003541)2.41174103
71Mucopolysacchariduria (HP:0008155)2.41174103
72Hypolipoproteinemia (HP:0010981)2.38515175
73Hyperacusis (HP:0010780)2.38170387
74Broad alveolar ridges (HP:0000187)2.34980866
75Renal duplication (HP:0000075)2.33619358
76Facial diplegia (HP:0001349)2.28970094
77Acanthocytosis (HP:0001927)2.26637817
78Hyperkalemia (HP:0002153)2.25813095
79Ovoid vertebral bodies (HP:0003300)2.24289241
80Nausea (HP:0002018)2.24284690
81Metaphyseal cupping (HP:0003021)2.21992767
82Menstrual irregularities (HP:0000858)2.21143137
83Epiphyseal dysplasia (HP:0002656)2.20384626
84Abnormality of aromatic amino acid family metabolism (HP:0004338)2.18779505
85Coxa vara (HP:0002812)2.18355759
86Abnormality of mucopolysaccharide metabolism (HP:0011020)2.17821405
87Abnormality of polysaccharide metabolism (HP:0011012)2.17821405
88Abnormality of glycosaminoglycan metabolism (HP:0004371)2.17821405
89Accelerated skeletal maturation (HP:0005616)2.16546407
90Abnormality of the wing of the ilium (HP:0011867)2.15466501
91Nephritis (HP:0000123)2.14623643
92Abnormality of the lower motor neuron (HP:0002366)2.14173209
93Choanal stenosis (HP:0000452)2.13319663
94Short humerus (HP:0005792)2.11268486
95Distal upper limb amyotrophy (HP:0007149)2.08130636
96Upper limb amyotrophy (HP:0009129)2.08130636
97Overriding aorta (HP:0002623)2.04691892
98Hypoalphalipoproteinemia (HP:0003233)2.03813837
99Bronchomalacia (HP:0002780)2.03441684
100Abnormality of potassium homeostasis (HP:0011042)1.99406155
101Increased variability in muscle fiber diameter (HP:0003557)1.98805379
102Absent epiphyses (HP:0010577)1.98708103
103Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.98708103
104Type 1 muscle fiber predominance (HP:0003803)1.97831376
105Neurofibrillary tangles (HP:0002185)1.97503281
106Purpura (HP:0000979)1.97429788
107Insomnia (HP:0100785)1.97181812
108Precocious puberty (HP:0000826)1.97029994
109Limb-girdle muscle weakness (HP:0003325)1.96385214
110Ulnar bowing (HP:0003031)1.95767707
111Stridor (HP:0010307)1.95275322
112Elfin facies (HP:0004428)1.94055260
113Limited elbow extension (HP:0001377)1.94013548
114Tongue fasciculations (HP:0001308)1.93842523
115Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.92675253
116Arthropathy (HP:0003040)1.92646322
117Increased nuchal translucency (HP:0010880)1.92604511
118Myelomeningocele (HP:0002475)1.92531029
119Myocardial infarction (HP:0001658)1.91204289
120Facial shape deformation (HP:0011334)1.91053246
121Potter facies (HP:0002009)1.91053246
122Hypophosphatemic rickets (HP:0004912)1.90490034
123Selective tooth agenesis (HP:0001592)1.87159356
124Osteomalacia (HP:0002749)1.86699461
125Hepatoblastoma (HP:0002884)1.86130606
126Short femoral neck (HP:0100864)1.85688266
127Ankle clonus (HP:0011448)1.84767004
128Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.84715232
129Proximal placement of thumb (HP:0009623)1.84464399
130Bifid scrotum (HP:0000048)1.84041138
131Muscle fibrillation (HP:0010546)1.83522832
132Cupped ear (HP:0000378)1.82984099
133Abnormality of pain sensation (HP:0010832)1.82820281
134Impaired pain sensation (HP:0007328)1.82820281
135Abnormality of the pubic bones (HP:0003172)1.81834892
13611 pairs of ribs (HP:0000878)1.81316890
137Alacrima (HP:0000522)1.81231928
138Irregular epiphyses (HP:0010582)1.80989214
139Aplasia/hypoplasia of the humerus (HP:0006507)1.80781833
140* Primary amenorrhea (HP:0000786)1.79227702
141Transposition of the great arteries (HP:0001669)1.79225831
142Abnormal connection of the cardiac segments (HP:0011545)1.79225831
143Abnormal ventriculo-arterial connection (HP:0011563)1.79225831
144Abnormality of the acetabulum (HP:0003170)1.78467566
145Aortic aneurysm (HP:0004942)1.77880310
146Abnormality of dentin (HP:0010299)1.77624416
147Inguinal hernia (HP:0000023)1.77383575
148Absent eyebrow (HP:0002223)1.77294368
149Slender build (HP:0001533)1.76620680
150Spontaneous abortion (HP:0005268)1.76589489
151Broad metatarsal (HP:0001783)1.74489686
152Shawl scrotum (HP:0000049)1.74229333
153Tracheal stenosis (HP:0002777)1.72577403
154Abnormality of the 4th metacarpal (HP:0010012)1.71387799
155Complete atrioventricular canal defect (HP:0001674)1.69672487
156Spinal rigidity (HP:0003306)1.67884908
157Hypoplastic heart (HP:0001961)1.67212473
158Heterotopia (HP:0002282)1.66749980
159Sprengel anomaly (HP:0000912)1.64645215
160Short 4th metacarpal (HP:0010044)1.64643553
161Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.64643553
162Flat cornea (HP:0007720)1.63567376
163Deviation of the thumb (HP:0009603)1.62436913
164Abnormality of skeletal muscle fiber size (HP:0012084)1.62303188
165Overlapping toe (HP:0001845)1.60408875
166Pointed chin (HP:0000307)1.59384113
167Coronal craniosynostosis (HP:0004440)1.58900757
168Gynecomastia (HP:0000771)1.56961449
169Abnormality of the peritoneum (HP:0002585)1.56510415
170Premature rupture of membranes (HP:0001788)1.56458417
171Neoplasm of the heart (HP:0100544)1.54588847
172Hypospadias (HP:0000047)1.51830559
173Aortic dissection (HP:0002647)1.51312622
174Thin bony cortex (HP:0002753)1.50987331
175Bowel diverticulosis (HP:0005222)1.50112655
176Episodic fever (HP:0001954)1.47674242
177Hypokalemia (HP:0002900)1.47489019
178Diaphragmatic weakness (HP:0009113)1.46681513
179Buphthalmos (HP:0000557)1.46262030
180Breech presentation (HP:0001623)1.45847860

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.38931843
2TYRO34.47521664
3CDK123.93819495
4FGFR33.56567471
5ICK3.15117817
6RIPK13.04010044
7PRPF4B2.69396607
8PDGFRA2.55102590
9LATS12.52719743
10PKN22.45543085
11PTK62.42004541
12PRKD32.32558848
13WNK31.94994113
14AKT31.93027894
15BRD41.87340948
16TAOK21.87103864
17WNK41.79770912
18ERN11.79430581
19EEF2K1.67437453
20CDK41.67025061
21DAPK21.54481645
22MAP3K41.52110853
23CAMK1G1.48702674
24NEK21.48332627
25EPHB21.46402838
26MAP3K51.45764311
27PAK41.42153333
28WNK11.41432001
29PRKAA21.40475245
30PDPK11.33346886
31STK31.32978321
32CAMK1D1.29446846
33CDK91.28080331
34FGFR21.26615516
35TESK11.22666869
36CDC71.22083369
37KSR21.20610382
38MTOR1.19348734
39PDK11.17832898
40PDK31.17828458
41PDK41.17828458
42MYLK1.17373597
43LATS21.15962563
44CSNK1A1L1.15927289
45LMTK21.13568434
46JAK11.12802736
47PTK2B1.11700651
48FGFR11.07053132
49FER0.97244355
50PAK20.93983671
51NEK90.93199051
52MAP3K100.90216478
53PIK3CA0.88688786
54SIK20.88456751
55CDC42BPA0.87866141
56SGK10.86492553
57EPHA40.85639841
58MAP3K20.85051332
59FGR0.84822018
60PNCK0.84580968
61TTN0.82619744
62SGK4940.82528010
63SGK2230.82528010
64RET0.80786147
65AKT20.80584728
66PDGFRB0.80038787
67SCYL20.78438138
68MAPK110.77829534
69PTK20.75149650
70TGFBR20.74999180
71SMG10.74479941
72STK390.73654599
73CSF1R0.73542767
74MAP2K20.72402520
75CDK60.71946345
76SGK30.69460530
77TNK20.68793178
78MAP3K70.67990745
79PAK30.66913644
80ERBB20.64989837
81MET0.64153973
82LRRK20.60843234
83SGK20.58341784
84FGFR40.57304377
85BMX0.56327271
86TGFBR10.53999596
87* CDK70.53436047
88YES10.53223692
89TAOK30.52750069
90RPS6KB10.52257400
91PRKAA10.50826345
92PRKCZ0.50202589
93EPHB10.49749548
94NLK0.48935871
95WEE10.48733244
96SIK10.48147312
97MATK0.48038467
98DMPK0.46448389
99PASK0.45824802
100ACVR1B0.45505404
101ATM0.44152271
102NTRK30.44134665
103CHEK10.43833297
104MAPK120.42723006
105NTRK20.42625304
106DYRK1B0.42311852
107MELK0.42107682
108PRKACB0.41955763
109PDK20.41800632
110DAPK10.41754116
111CAMK40.41539903
112ILK0.40814165
113RPS6KA10.39466876
114JAK20.38431780
115PAK10.37923421
116CSNK1G10.37543962
117MAP2K40.37366272
118CSNK1G20.36642663
119KSR10.36111274
120MARK20.35315878
121MAP2K10.35190600
122* MAPK10.35073799
123CDK20.34467128
124EIF2AK10.34376056
125DDR20.34315385
126NTRK10.33836951
127* MAPK30.33762514
128MINK10.33617263
129* CDK10.32120304
130CSNK1G30.31144337
131MAP3K10.29361861
132UHMK10.29185369
133SRC0.28337072
134STK380.28318172
135* GSK3B0.27626021
136PRKCH0.27532473
137LIMK10.27277569
138RPS6KA30.27229793
139CSNK1E0.27057558
140CDK80.26796241
141PRKACG0.26725061
142NEK10.26708681
143PRKDC0.26273363
144IRAK30.25577680
145PIM10.24990348
146FLT30.24850606
147MAPKAPK30.24397831
148MAP3K110.22993077
149CSNK1D0.21966831
150MAP2K60.21004485
151AKT10.20767960
152MAP2K30.20386337
153MAPK90.19462311
154IGF1R0.18575906
155PRKACA0.18479514

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid hormone biosynthesis_Homo sapiens_hsa001407.09341055
2Ovarian steroidogenesis_Homo sapiens_hsa049136.76873210
3Aldosterone synthesis and secretion_Homo sapiens_hsa049254.62712161
4Fatty acid biosynthesis_Homo sapiens_hsa000612.94385390
5Vitamin B6 metabolism_Homo sapiens_hsa007502.74046133
6Fatty acid metabolism_Homo sapiens_hsa012122.60394288
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.17920972
8Hedgehog signaling pathway_Homo sapiens_hsa043402.17272218
9Other glycan degradation_Homo sapiens_hsa005112.11921554
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.09457315
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.07631670
12Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.86366732
13Vitamin digestion and absorption_Homo sapiens_hsa049771.77457695
14ECM-receptor interaction_Homo sapiens_hsa045121.69461687
15TGF-beta signaling pathway_Homo sapiens_hsa043501.69143454
16Histidine metabolism_Homo sapiens_hsa003401.63869822
17Fatty acid degradation_Homo sapiens_hsa000711.61149589
18Prion diseases_Homo sapiens_hsa050201.59991617
19Staphylococcus aureus infection_Homo sapiens_hsa051501.59388355
20Pyruvate metabolism_Homo sapiens_hsa006201.54242665
21Lysine degradation_Homo sapiens_hsa003101.53235772
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.52974434
23Dorso-ventral axis formation_Homo sapiens_hsa043201.46458467
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.46410074
25PPAR signaling pathway_Homo sapiens_hsa033201.40481794
26Arginine biosynthesis_Homo sapiens_hsa002201.40310576
27Basal cell carcinoma_Homo sapiens_hsa052171.32079502
28ABC transporters_Homo sapiens_hsa020101.31612330
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.31349504
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30321019
31Renin secretion_Homo sapiens_hsa049241.27978523
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.16574301
33Fat digestion and absorption_Homo sapiens_hsa049751.15991517
34Focal adhesion_Homo sapiens_hsa045101.14079562
35Small cell lung cancer_Homo sapiens_hsa052221.10461100
36cAMP signaling pathway_Homo sapiens_hsa040241.10157641
37Amoebiasis_Homo sapiens_hsa051461.06607161
38Protein digestion and absorption_Homo sapiens_hsa049741.03493499
39Hippo signaling pathway_Homo sapiens_hsa043901.02906166
40Pentose and glucuronate interconversions_Homo sapiens_hsa000400.98813287
41Chemical carcinogenesis_Homo sapiens_hsa052040.96683295
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96072442
43Arginine and proline metabolism_Homo sapiens_hsa003300.95409140
44Renin-angiotensin system_Homo sapiens_hsa046140.94911464
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94305566
46Phenylalanine metabolism_Homo sapiens_hsa003600.92255556
47Bile secretion_Homo sapiens_hsa049760.89104217
48Tyrosine metabolism_Homo sapiens_hsa003500.88017929
49mRNA surveillance pathway_Homo sapiens_hsa030150.87483676
50Axon guidance_Homo sapiens_hsa043600.85671709
51Adipocytokine signaling pathway_Homo sapiens_hsa049200.84699081
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84327583
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84173720
54Estrogen signaling pathway_Homo sapiens_hsa049150.83585206
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.83519341
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83139592
57Fatty acid elongation_Homo sapiens_hsa000620.81475475
58Prolactin signaling pathway_Homo sapiens_hsa049170.81204606
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79681335
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75266485
61Notch signaling pathway_Homo sapiens_hsa043300.74704438
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74454515
63Prostate cancer_Homo sapiens_hsa052150.74423393
64Oocyte meiosis_Homo sapiens_hsa041140.74360761
65Tryptophan metabolism_Homo sapiens_hsa003800.72723074
66Propanoate metabolism_Homo sapiens_hsa006400.72210934
67VEGF signaling pathway_Homo sapiens_hsa043700.71212082
68Proteoglycans in cancer_Homo sapiens_hsa052050.70650879
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69567762
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.68900976
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68504046
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64837579
73Insulin resistance_Homo sapiens_hsa049310.64430133
74GnRH signaling pathway_Homo sapiens_hsa049120.64164952
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63947281
76Pertussis_Homo sapiens_hsa051330.62611790
77Wnt signaling pathway_Homo sapiens_hsa043100.62609929
78Galactose metabolism_Homo sapiens_hsa000520.61689516
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61481458
80Sulfur metabolism_Homo sapiens_hsa009200.60214524
81Sphingolipid metabolism_Homo sapiens_hsa006000.59694786
82Adherens junction_Homo sapiens_hsa045200.59668913
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59012886
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56651344
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56361408
86Starch and sucrose metabolism_Homo sapiens_hsa005000.56150065
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55085869
88Linoleic acid metabolism_Homo sapiens_hsa005910.54685226
89Toxoplasmosis_Homo sapiens_hsa051450.54350236
90Melanogenesis_Homo sapiens_hsa049160.53561412
91Thyroid hormone synthesis_Homo sapiens_hsa049180.52842074
92Butanoate metabolism_Homo sapiens_hsa006500.52738419
93Mineral absorption_Homo sapiens_hsa049780.50934792
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50723879
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50235361
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.49970751
97Fructose and mannose metabolism_Homo sapiens_hsa000510.49945916
98Viral myocarditis_Homo sapiens_hsa054160.49853332
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49617260
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.48770814
101Tight junction_Homo sapiens_hsa045300.48479599
102Peroxisome_Homo sapiens_hsa041460.48264695
103AMPK signaling pathway_Homo sapiens_hsa041520.47891462
104Oxytocin signaling pathway_Homo sapiens_hsa049210.47487848
105Glutathione metabolism_Homo sapiens_hsa004800.47123456
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46977403
107Selenocompound metabolism_Homo sapiens_hsa004500.45812127
108Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45565926
109Glucagon signaling pathway_Homo sapiens_hsa049220.44849575
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44183220
111mTOR signaling pathway_Homo sapiens_hsa041500.43815580
112Pathways in cancer_Homo sapiens_hsa052000.42916534
113Biosynthesis of amino acids_Homo sapiens_hsa012300.42188211
114beta-Alanine metabolism_Homo sapiens_hsa004100.41484896
115Steroid biosynthesis_Homo sapiens_hsa001000.41273041
116Carbon metabolism_Homo sapiens_hsa012000.40906913
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38569234
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36034006
119HTLV-I infection_Homo sapiens_hsa051660.35769638
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.34873371
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.34312312
122Glycerolipid metabolism_Homo sapiens_hsa005610.34126400
123Endometrial cancer_Homo sapiens_hsa052130.34081201
124Colorectal cancer_Homo sapiens_hsa052100.33918498
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.33405376
126Insulin signaling pathway_Homo sapiens_hsa049100.33339243
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32696891
128Glioma_Homo sapiens_hsa052140.31958732
129Lysosome_Homo sapiens_hsa041420.31232870
130Gastric acid secretion_Homo sapiens_hsa049710.31092062
131N-Glycan biosynthesis_Homo sapiens_hsa005100.30577928
132Non-small cell lung cancer_Homo sapiens_hsa052230.29880016
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29605392
134Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.29584848
135Retinol metabolism_Homo sapiens_hsa008300.28957995
136Chronic myeloid leukemia_Homo sapiens_hsa052200.27753642
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27546382
138Metabolic pathways_Homo sapiens_hsa011000.26121792
139Complement and coagulation cascades_Homo sapiens_hsa046100.24503993
140Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24283273
141Renal cell carcinoma_Homo sapiens_hsa052110.24246935
142Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.24220959
143Antigen processing and presentation_Homo sapiens_hsa046120.23778377
144Cell cycle_Homo sapiens_hsa041100.23654877
145Choline metabolism in cancer_Homo sapiens_hsa052310.23135333
146Dopaminergic synapse_Homo sapiens_hsa047280.22973674
147Gap junction_Homo sapiens_hsa045400.22717986
148Sulfur relay system_Homo sapiens_hsa041220.22035509
149Pancreatic cancer_Homo sapiens_hsa052120.21857517
150Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21754678
151HIF-1 signaling pathway_Homo sapiens_hsa040660.20251325
152Pentose phosphate pathway_Homo sapiens_hsa000300.15548113

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