NR5A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a DNA-binding zinc finger transcription factor and is a member of the fushi tarazu factor-1 subfamily of orphan nuclear receptors. The encoded protein is involved in the expression of genes for hepatitis B virus and cholesterol biosynthesis, and may be an important regulator of embryonic development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine metabolic process (GO:0006558)6.06378530
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.06378530
3L-phenylalanine catabolic process (GO:0006559)5.97784396
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.97784396
5sulfur amino acid catabolic process (GO:0000098)5.82465382
6serine family amino acid catabolic process (GO:0009071)5.69495626
7aromatic amino acid family catabolic process (GO:0009074)5.44932782
8uronic acid metabolic process (GO:0006063)5.43343729
9glucuronate metabolic process (GO:0019585)5.43343729
10proline biosynthetic process (GO:0006561)5.38217704
11epoxygenase P450 pathway (GO:0019373)5.24957341
12glyoxylate metabolic process (GO:0046487)5.17564044
13exogenous drug catabolic process (GO:0042738)5.13297589
14glycine metabolic process (GO:0006544)5.11496498
15tryptophan catabolic process (GO:0006569)4.98799412
16indole-containing compound catabolic process (GO:0042436)4.98799412
17indolalkylamine catabolic process (GO:0046218)4.98799412
18kynurenine metabolic process (GO:0070189)4.97269439
19triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.96671232
20cysteine metabolic process (GO:0006534)4.96464204
21negative regulation of fatty acid biosynthetic process (GO:0045717)4.86351102
22proline metabolic process (GO:0006560)4.80034684
23urea cycle (GO:0000050)4.73883073
24urea metabolic process (GO:0019627)4.73883073
25digestion (GO:0007586)4.73638999
26intestinal absorption (GO:0050892)4.71341875
27tryptophan metabolic process (GO:0006568)4.69391263
28bile acid biosynthetic process (GO:0006699)4.68001233
29serine family amino acid metabolic process (GO:0009069)4.51696590
30negative regulation of fibrinolysis (GO:0051918)4.50002966
31intestinal cholesterol absorption (GO:0030299)4.41175819
32flavonoid metabolic process (GO:0009812)4.40398670
33nitrogen cycle metabolic process (GO:0071941)4.38867246
34homocysteine metabolic process (GO:0050667)4.38569007
35regulation of protein activation cascade (GO:2000257)4.38272348
36acylglycerol homeostasis (GO:0055090)4.36892482
37triglyceride homeostasis (GO:0070328)4.36892482
38high-density lipoprotein particle remodeling (GO:0034375)4.34535173
39drug metabolic process (GO:0017144)4.29546893
40transcription from mitochondrial promoter (GO:0006390)4.28561615
41regulation of fibrinolysis (GO:0051917)4.24349268
42serine family amino acid biosynthetic process (GO:0009070)4.22316283
43omega-hydroxylase P450 pathway (GO:0097267)4.22003763
44complement activation, alternative pathway (GO:0006957)4.20912324
45very-low-density lipoprotein particle assembly (GO:0034379)4.20519031
46peptidyl-glutamic acid carboxylation (GO:0017187)4.20006968
47protein carboxylation (GO:0018214)4.20006968
48aromatic amino acid family metabolic process (GO:0009072)4.19255571
49glutamine family amino acid biosynthetic process (GO:0009084)4.19047445
50alpha-linolenic acid metabolic process (GO:0036109)4.16529347
51regulation of complement activation (GO:0030449)4.08449169
52alpha-amino acid catabolic process (GO:1901606)4.04745748
53heme transport (GO:0015886)4.01922718
54* bile acid metabolic process (GO:0008206)3.99368868
55cobalamin metabolic process (GO:0009235)3.92414542
56drug transmembrane transport (GO:0006855)3.90208473
57amino-acid betaine metabolic process (GO:0006577)3.88732505
58regulation of cholesterol homeostasis (GO:2000188)3.83780111
59cellular amino acid catabolic process (GO:0009063)3.83085835
60oxidative demethylation (GO:0070989)3.75190272
61cholesterol efflux (GO:0033344)3.74132596
62bile acid and bile salt transport (GO:0015721)3.72618599
63androgen biosynthetic process (GO:0006702)3.70895883
64imidazole-containing compound metabolic process (GO:0052803)3.70087220
65regulation of cholesterol esterification (GO:0010872)3.69789633
66reverse cholesterol transport (GO:0043691)3.69320844
67regulation of bile acid biosynthetic process (GO:0070857)3.68204374
68negative regulation of cholesterol transport (GO:0032375)3.64611296
69negative regulation of sterol transport (GO:0032372)3.64611296
70plasma lipoprotein particle assembly (GO:0034377)3.64431923
71cytolysis (GO:0019835)3.63285540
72macromolecular complex remodeling (GO:0034367)3.62931433
73plasma lipoprotein particle remodeling (GO:0034369)3.62931433
74protein-lipid complex remodeling (GO:0034368)3.62931433
75sphingosine metabolic process (GO:0006670)3.61687379
76lysine metabolic process (GO:0006553)3.60878056
77lysine catabolic process (GO:0006554)3.60878056
78sulfate transmembrane transport (GO:1902358)3.60859062
79tyrosine metabolic process (GO:0006570)3.60422365
80transcytosis (GO:0045056)3.58822882
81regulation of triglyceride catabolic process (GO:0010896)3.55732289
82fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.55352763
83sulfation (GO:0051923)3.54214677
84alkaloid metabolic process (GO:0009820)3.49681698
85sphingoid metabolic process (GO:0046519)3.48336688
86transepithelial transport (GO:0070633)3.44631432
87negative regulation of fatty acid metabolic process (GO:0045922)3.43813136
88cellular biogenic amine catabolic process (GO:0042402)3.42618455
89amine catabolic process (GO:0009310)3.42618455
90diol metabolic process (GO:0034311)3.41405889
91indolalkylamine metabolic process (GO:0006586)3.41377194
92benzene-containing compound metabolic process (GO:0042537)3.40047405
93L-serine metabolic process (GO:0006563)3.37600027
94folic acid metabolic process (GO:0046655)3.37529352
95iron coordination entity transport (GO:1901678)3.37411221
96glucocorticoid biosynthetic process (GO:0006704)3.35609961
97drug transport (GO:0015893)3.34472516
98phospholipid efflux (GO:0033700)3.33025538
99plasma lipoprotein particle clearance (GO:0034381)3.32740262
100organic cation transport (GO:0015695)3.31688990
101acetyl-CoA metabolic process (GO:0006084)3.29569699
102coenzyme catabolic process (GO:0009109)3.28489883
103positive regulation of triglyceride metabolic process (GO:0090208)3.28368852
104embryonic process involved in female pregnancy (GO:0060136)3.26707057
105androgen metabolic process (GO:0008209)3.25652863
106cellular modified amino acid catabolic process (GO:0042219)3.23917394
107glutamate metabolic process (GO:0006536)3.23604520
108carboxylic acid catabolic process (GO:0046395)3.22481535
109organic acid catabolic process (GO:0016054)3.22481535
110hormone catabolic process (GO:0042447)3.21251618
111fucose catabolic process (GO:0019317)3.20870446
112L-fucose metabolic process (GO:0042354)3.20870446
113L-fucose catabolic process (GO:0042355)3.20870446
114replication fork processing (GO:0031297)3.20156286
115protein-lipid complex assembly (GO:0065005)3.19141861
116mitochondrial DNA metabolic process (GO:0032042)3.18553220
117arginine metabolic process (GO:0006525)3.18348259
118cellular glucuronidation (GO:0052695)3.17722685
119water-soluble vitamin biosynthetic process (GO:0042364)3.17110678
120regulation of transforming growth factor beta2 production (GO:0032909)3.17000039
121ethanol oxidation (GO:0006069)3.16570526
122* cholesterol homeostasis (GO:0042632)3.16502783
123biotin metabolic process (GO:0006768)3.15847611
124drug catabolic process (GO:0042737)3.15770149
125phosphatidylinositol acyl-chain remodeling (GO:0036149)3.15540230
126pyridine nucleotide biosynthetic process (GO:0019363)3.14873930
127nicotinamide nucleotide biosynthetic process (GO:0019359)3.14873930
128* sterol homeostasis (GO:0055092)3.11044033
129pantothenate metabolic process (GO:0015939)3.10799976
130S-adenosylmethionine metabolic process (GO:0046500)3.10290067
131sulfur amino acid metabolic process (GO:0000096)3.09364021
132NAD biosynthetic process (GO:0009435)3.08999784
133cellular ketone body metabolic process (GO:0046950)3.07370725
134sulfate transport (GO:0008272)3.06876264
135phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.03532844
136blood coagulation, intrinsic pathway (GO:0007597)2.99964590
137phenylpropanoid metabolic process (GO:0009698)2.99742539
138toxin metabolic process (GO:0009404)2.97448627
139sterol transport (GO:0015918)2.96908413
140cholesterol transport (GO:0030301)2.96908413
141ketone body metabolic process (GO:1902224)2.95349248
142daunorubicin metabolic process (GO:0044597)2.94299451
143polyketide metabolic process (GO:0030638)2.94299451
144doxorubicin metabolic process (GO:0044598)2.94299451
145regulation of guanylate cyclase activity (GO:0031282)2.93486300
146regulation of triglyceride metabolic process (GO:0090207)2.90823886
147kidney morphogenesis (GO:0060993)2.90319742
148urate metabolic process (GO:0046415)2.85187377
149glycerol metabolic process (GO:0006071)2.83564839
150phosphatidylserine acyl-chain remodeling (GO:0036150)2.82307669
151xenobiotic metabolic process (GO:0006805)2.78946621
152behavioral response to nicotine (GO:0035095)2.77430130
153sulfur compound transport (GO:0072348)2.72891194
154regulation of protein glycosylation (GO:0060049)2.72677490
155positive regulation of fatty acid transport (GO:2000193)2.71193299
156positive regulation of icosanoid secretion (GO:0032305)2.68852013
157positive regulation of lipid catabolic process (GO:0050996)2.66161604
158xenobiotic catabolic process (GO:0042178)2.65931235
159arginine catabolic process (GO:0006527)2.64791350

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.19072661
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.56838141
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.82978774
4* LXR_22158963_ChIP-Seq_LIVER_Mouse4.11495589
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.06403612
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.58790640
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.51845674
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.09079596
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.07113740
10VDR_22108803_ChIP-Seq_LS180_Human2.92515627
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.64500336
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.59149873
13ZNF274_21170338_ChIP-Seq_K562_Hela2.56263539
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.47384285
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.47384285
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.47384285
17* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.34400088
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.21954412
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.16295158
20E2F7_22180533_ChIP-Seq_HELA_Human2.15145276
21NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.14940369
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.13821974
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.10714560
24STAT3_1855785_ChIP-Seq_MESCs_Mouse2.09140370
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.05241177
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00135890
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.97619923
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.96482502
29P300_19829295_ChIP-Seq_ESCs_Human1.94301165
30IGF1R_20145208_ChIP-Seq_DFB_Human1.89062574
31NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.88815993
32GATA4_25053715_ChIP-Seq_YYC3_Human1.86021186
33ESR1_15608294_ChIP-ChIP_MCF-7_Human1.85927686
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85623780
35NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.85399677
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.85222521
37ZNF263_19887448_ChIP-Seq_K562_Human1.84827998
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.80803160
39CDX2_20551321_ChIP-Seq_CACO-2_Human1.80612244
40SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.79878287
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78894733
42* GBX2_23144817_ChIP-Seq_PC3_Human1.76507600
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65858219
44* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.63643893
45CDX2_22108803_ChIP-Seq_LS180_Human1.63210373
46* ER_23166858_ChIP-Seq_MCF-7_Human1.62528754
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.60815930
48BCAT_22108803_ChIP-Seq_LS180_Human1.60578499
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59531446
50* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.58459253
51POU5F1_16518401_ChIP-PET_MESCs_Mouse1.54060496
52SOX2_19829295_ChIP-Seq_ESCs_Human1.53061575
53NANOG_19829295_ChIP-Seq_ESCs_Human1.53061575
54AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.53013627
55RXRA_24833708_ChIP-Seq_LIVER_Mouse1.52859975
56EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.51139848
57* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.50770841
58* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.50701330
59FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.50574773
60* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50052051
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48056495
62* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45938836
63* NFE2_27457419_Chip-Seq_LIVER_Mouse1.44763831
64MYC_19030024_ChIP-ChIP_MESCs_Mouse1.43903926
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.43372019
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43330048
67ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41894418
68* EZH2_27294783_Chip-Seq_NPCs_Mouse1.41782492
69TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41309858
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40205458
71BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.40011012
72TCF4_22108803_ChIP-Seq_LS180_Human1.39989624
73* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38977991
74FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.37142648
75ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36508640
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35601017
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35499782
78* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.34857562
79CBP_20019798_ChIP-Seq_JUKART_Human1.34307946
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34307946
81CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.34043900
82STAT3_23295773_ChIP-Seq_U87_Human1.32820588
83FUS_26573619_Chip-Seq_HEK293_Human1.30712010
84SMAD4_21741376_ChIP-Seq_EPCs_Human1.29884029
85* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29700938
86* FOXA1_25329375_ChIP-Seq_VCAP_Human1.29700938
87SALL1_21062744_ChIP-ChIP_HESCs_Human1.28738343
88AR_20517297_ChIP-Seq_VCAP_Human1.28641116
89NANOG_21062744_ChIP-ChIP_HESCs_Human1.28636733
90POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28202248
91GATA3_21878914_ChIP-Seq_MCF-7_Human1.28067750
92AR_21909140_ChIP-Seq_LNCAP_Human1.27380243
93JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.26817364
94TCF4_23295773_ChIP-Seq_U87_Human1.26570375
95AUTS2_25519132_ChIP-Seq_293T-REX_Human1.26406256
96PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.24112950
97E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23958894
98NCOR_22424771_ChIP-Seq_293T_Human1.23724785
99NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.23686664
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23258255
101* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23097392
102KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22178093
103SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21562250
104DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21267445
105HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21162999
106* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.20845852
107* AR_25329375_ChIP-Seq_VCAP_Human1.20283252
108MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18682479
109SMAD4_21799915_ChIP-Seq_A2780_Human1.18257739
110KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17589791
111TAF15_26573619_Chip-Seq_HEK293_Human1.17571921
112HOXB7_26014856_ChIP-Seq_BT474_Human1.16959086
113EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16837381
114SMAD3_21741376_ChIP-Seq_EPCs_Human1.16306892
115* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.16123231
116* FOXA1_25552417_ChIP-Seq_VCAP_Human1.15459035
117EWS_26573619_Chip-Seq_HEK293_Human1.15160044
118* RARA_24833708_ChIP-Seq_LIVER_Mouse1.13987515
119* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.13150827
120ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12249438
121TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12198940
122* CRX_20693478_ChIP-Seq_RETINA_Mouse1.12102655
123KDM5A_27292631_Chip-Seq_BREAST_Human1.11577576
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11521364
125* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.11182831
126* RARB_24833708_ChIP-Seq_LIVER_Mouse1.10722021
127ESR1_21235772_ChIP-Seq_MCF-7_Human1.10115740
128SMAD3_21741376_ChIP-Seq_HESCs_Human1.09875582
129POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09646296
130STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09352853
131SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07828942
132NELFA_20434984_ChIP-Seq_ESCs_Mouse1.07648788
133RUNX2_22187159_ChIP-Seq_PCA_Human1.06405897
134* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06288177
135TP53_22573176_ChIP-Seq_HFKS_Human1.06134907
136* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05743070
137FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04752261
138* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.04148907
139FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03835410
140* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03641813
141SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03447863
142* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03178170
143* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.02587026
144TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02475663
145POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02475663
146FOXO3_23340844_ChIP-Seq_DLD1_Human1.01224878
147STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01101169
148* PHF8_20622853_ChIP-Seq_HELA_Human1.00386061
149TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00126056
150KAP1_27257070_Chip-Seq_ESCs_Mouse1.00082901
151BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99328499
152TCF4_18268006_ChIP-ChIP_LS174T_Human0.99260463
153ETS1_20019798_ChIP-Seq_JURKAT_Human0.98815530
154NANOG_16518401_ChIP-PET_MESCs_Mouse0.98523694
155* HNF4A_19822575_ChIP-Seq_HepG2_Human0.98023078
156CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97682544
157FOXH1_21741376_ChIP-Seq_EPCs_Human0.97606763
158CEBPB_22108803_ChIP-Seq_LS180_Human0.97573482
159NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.96192419
160SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95781115
161* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.93157347
162ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92936835
163CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.91902444
164CLOCK_20551151_ChIP-Seq_293T_Human0.89952309
165* GABP_19822575_ChIP-Seq_HepG2_Human0.89274258
166SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88132318
167TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87174128
168E2F4_17652178_ChIP-ChIP_JURKAT_Human0.87153210
169SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.86999480
170RACK7_27058665_Chip-Seq_MCF-7_Human0.86963099
171CREB1_15753290_ChIP-ChIP_HEK293T_Human0.86811685
172TET1_21451524_ChIP-Seq_MESCs_Mouse0.86267871
173RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86219952
174YY1_21170310_ChIP-Seq_MESCs_Mouse0.86158827
175ZFX_18555785_ChIP-Seq_MESCs_Mouse0.85498801
176* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.85308817
177SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85260539
178ERG_21242973_ChIP-ChIP_JURKAT_Human0.85161448
179PU.1_20513432_ChIP-Seq_Bcells_Mouse0.82805875
180SPI1_26923725_Chip-Seq_HPCs_Mouse0.82201295
181DCP1A_22483619_ChIP-Seq_HELA_Human0.78559083
182* LXR_22292898_ChIP-Seq_THP-1_Human0.78556816
183MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.77902461
184EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.77726258
185RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.77587672
186KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77262007
187ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77084925
188* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.76636753

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.94157854
2MP0005360_urolithiasis6.25720832
3* MP0005085_abnormal_gallbladder_physiolo5.53248757
4* MP0005365_abnormal_bile_salt5.33865374
5MP0003806_abnormal_nucleotide_metabolis4.22110510
6MP0008875_abnormal_xenobiotic_pharmacok4.06166212
7MP0003252_abnormal_bile_duct3.19237624
8MP0009840_abnormal_foam_cell3.02963924
9MP0002876_abnormal_thyroid_physiology3.00133633
10MP0010329_abnormal_lipoprotein_level2.96868946
11MP0005083_abnormal_biliary_tract2.73324623
12MP0002837_dystrophic_cardiac_calcinosis2.61289975
13MP0008057_abnormal_DNA_replication2.59972766
14MP0001666_abnormal_nutrient_absorption2.59855691
15MP0003283_abnormal_digestive_organ2.54582234
16MP0005332_abnormal_amino_acid2.39936729
17MP0004019_abnormal_vitamin_homeostasis2.23956152
18MP0003136_yellow_coat_color2.02633006
19MP0000609_abnormal_liver_physiology2.02512203
20MP0003195_calcinosis1.99538770
21MP0004043_abnormal_pH_regulation1.98648473
22MP0008872_abnormal_physiological_respon1.94670579
23MP0004147_increased_porphyrin_level1.90115580
24MP0003718_maternal_effect1.79956096
25MP0010386_abnormal_urinary_bladder1.76360169
26MP0008004_abnormal_stomach_pH1.75302523
27MP0003300_gastrointestinal_ulcer1.74515790
28MP0001873_stomach_inflammation1.73034568
29MP0003191_abnormal_cellular_cholesterol1.71020866
30MP0003868_abnormal_feces_composition1.68798747
31* MP0002118_abnormal_lipid_homeostasis1.68667996
32MP0005670_abnormal_white_adipose1.65559120
33MP0001501_abnormal_sleep_pattern1.59790275
34MP0003705_abnormal_hypodermis_morpholog1.58770542
35MP0003045_fibrosis1.56346196
36MP0001764_abnormal_homeostasis1.50613748
37MP0003646_muscle_fatigue1.48540121
38MP0005647_abnormal_sex_gland1.47209964
39MP0005451_abnormal_body_composition1.46098941
40* MP0005319_abnormal_enzyme/_coenzyme1.45370007
41MP0003693_abnormal_embryo_hatching1.43545556
42MP0002138_abnormal_hepatobiliary_system1.35162709
43MP0001664_abnormal_digestion1.34064842
44MP0004957_abnormal_blastocyst_morpholog1.31490913
45MP0004264_abnormal_extraembryonic_tissu1.27684493
46MP0009278_abnormal_bone_marrow1.25469036
47MP0003890_abnormal_embryonic-extraembry1.24556284
48MP0000538_abnormal_urinary_bladder1.23793055
49MP0001485_abnormal_pinna_reflex1.23013871
50MP0005551_abnormal_eye_electrophysiolog1.22981212
51MP0000598_abnormal_liver_morphology1.21598663
52MP0003111_abnormal_nucleus_morphology1.19396021
53MP0005084_abnormal_gallbladder_morpholo1.18233907
54MP0003656_abnormal_erythrocyte_physiolo1.17622264
55MP0010094_abnormal_chromosome_stability1.15936255
56MP0004782_abnormal_surfactant_physiolog1.14074583
57MP0005171_absent_coat_pigmentation1.12998478
58MP0010368_abnormal_lymphatic_system1.12050441
59MP0003183_abnormal_peptide_metabolism1.11033013
60MP0005220_abnormal_exocrine_pancreas1.09650108
61MP0009053_abnormal_anal_canal1.07585524
62MP0005448_abnormal_energy_balance1.07578099
63MP0010030_abnormal_orbit_morphology1.05481723
64MP0008995_early_reproductive_senescence1.05426216
65MP0000639_abnormal_adrenal_gland1.05381984
66MP0002163_abnormal_gland_morphology1.04720766
67MP0005266_abnormal_metabolism1.02837833
68MP0003186_abnormal_redox_activity1.02762466
69MP0005395_other_phenotype1.02311628
70MP0003879_abnormal_hair_cell1.02173968
71MP0005636_abnormal_mineral_homeostasis1.01540569
72MP0001661_extended_life_span1.00079788
73MP0002796_impaired_skin_barrier0.99049391
74MP0000566_synostosis0.98560851
75MP0000579_abnormal_nail_morphology0.98162608
76MP0002928_abnormal_bile_duct0.97626993
77MP0003453_abnormal_keratinocyte_physiol0.97000946
78MP0003119_abnormal_digestive_system0.96462642
79* MP0002086_abnormal_extraembryonic_tissu0.94272108
80MP0002168_other_aberrant_phenotype0.92722465
81MP0002277_abnormal_respiratory_mucosa0.92430170
82MP0003786_premature_aging0.90535442
83MP0009697_abnormal_copulation0.90171708
84MP0001756_abnormal_urination0.88555940
85MP0000427_abnormal_hair_cycle0.87263352
86MP0009764_decreased_sensitivity_to0.86756332
87MP0001730_embryonic_growth_arrest0.85758850
88MP0002009_preneoplasia0.85195615
89MP0005584_abnormal_enzyme/coenzyme_acti0.84419976
90MP0001663_abnormal_digestive_system0.84156486
91* MP0005380_embryogenesis_phenotype0.83749451
92* MP0001672_abnormal_embryogenesis/_devel0.83749451
93MP0000230_abnormal_systemic_arterial0.83481032
94MP0005376_homeostasis/metabolism_phenot0.83062269
95MP0002938_white_spotting0.82466309
96MP0001986_abnormal_taste_sensitivity0.81920561
97MP0005397_hematopoietic_system_phenotyp0.80342778
98MP0001545_abnormal_hematopoietic_system0.80342778
99MP0002249_abnormal_larynx_morphology0.80124419
100MP0009643_abnormal_urine_homeostasis0.80041734
101* MP0003953_abnormal_hormone_level0.79440376
102MP0003077_abnormal_cell_cycle0.78633335
103MP0000470_abnormal_stomach_morphology0.78572001
104MP0005410_abnormal_fertilization0.78275060
105MP0008058_abnormal_DNA_repair0.78230564
106MP0005379_endocrine/exocrine_gland_phen0.77482287
107MP0001765_abnormal_ion_homeostasis0.77125076
108MP0004197_abnormal_fetal_growth/weight/0.76766684
109MP0002269_muscular_atrophy0.75797446
110MP0005381_digestive/alimentary_phenotyp0.72880891
111MP0010352_gastrointestinal_tract_polyps0.72216311
112MP0004233_abnormal_muscle_weight0.71842901
113MP0008877_abnormal_DNA_methylation0.71687884
114MP0006036_abnormal_mitochondrial_physio0.71639644
115MP0005389_reproductive_system_phenotype0.71284435
116MP0002653_abnormal_ependyma_morphology0.70900198
117MP0002088_abnormal_embryonic_growth/wei0.70713096
118MP0003984_embryonic_growth_retardation0.70711904
119MP0003567_abnormal_fetal_cardiomyocyte0.70619340
120MP0004215_abnormal_myocardial_fiber0.70324027
121MP0004145_abnormal_muscle_electrophysio0.69659600
122* MP0001697_abnormal_embryo_size0.69552242
123MP0003959_abnormal_lean_body0.69385492
124MP0002078_abnormal_glucose_homeostasis0.67448281
125MP0002909_abnormal_adrenal_gland0.67216315
126MP0001944_abnormal_pancreas_morphology0.66086576
127MP0002160_abnormal_reproductive_system0.64613454
128MP0003943_abnormal_hepatobiliary_system0.64171301
129MP0001293_anophthalmia0.63980129
130* MP0003699_abnormal_female_reproductive0.63757202
131* MP0002084_abnormal_developmental_patter0.63026249
132MP0002971_abnormal_brown_adipose0.61649205
133MP0002136_abnormal_kidney_physiology0.60683089
134MP0003011_delayed_dark_adaptation0.60373045
135MP0009115_abnormal_fat_cell0.60353063
136* MP0002085_abnormal_embryonic_tissue0.60238368
137MP0004185_abnormal_adipocyte_glucose0.59518822
138MP0002102_abnormal_ear_morphology0.58162029
139MP0004133_heterotaxia0.57981229
140MP0002254_reproductive_system_inflammat0.57223209
141MP0009763_increased_sensitivity_to0.56943077
142MP0002060_abnormal_skin_morphology0.56456488
143MP0000462_abnormal_digestive_system0.56454703
144MP0000350_abnormal_cell_proliferation0.56076559
145* MP0009642_abnormal_blood_homeostasis0.55779783
146MP0005248_abnormal_Harderian_gland0.55765991
147MP0001919_abnormal_reproductive_system0.55716793
148MP0003866_abnormal_defecation0.55531556
149MP0009672_abnormal_birth_weight0.55312178
150MP0000371_diluted_coat_color0.55287220
151* MP0002080_prenatal_lethality0.54922216
152MP0002693_abnormal_pancreas_physiology0.53912272
153MP0005076_abnormal_cell_differentiation0.53779767
154MP0000613_abnormal_salivary_gland0.53190144
155MP0005535_abnormal_body_temperature0.52892008
156MP0003137_abnormal_impulse_conducting0.50726418
157MP0008932_abnormal_embryonic_tissue0.49751298
158MP0002282_abnormal_trachea_morphology0.49173161
159MP0006035_abnormal_mitochondrial_morpho0.48416952
160MP0002111_abnormal_tail_morphology0.48232385
161MP0005253_abnormal_eye_physiology0.48161098
162MP0005377_hearing/vestibular/ear_phenot0.47971224
163MP0005334_abnormal_fat_pad0.47830701
164MP0005075_abnormal_melanosome_morpholog0.47691980
165MP0005501_abnormal_skin_physiology0.47547601

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.53218356
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.22408128
3Hypobetalipoproteinemia (HP:0003563)6.20922615
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.02783780
5Deep venous thrombosis (HP:0002625)5.88361115
6Hyperglycinemia (HP:0002154)5.33737919
7Xanthomatosis (HP:0000991)5.11927705
8Prolonged partial thromboplastin time (HP:0003645)5.04656103
9Hypochromic microcytic anemia (HP:0004840)4.83472738
10Hyperglycinuria (HP:0003108)4.68600603
11Hypolipoproteinemia (HP:0010981)4.44446090
12Hyperlipoproteinemia (HP:0010980)4.28497798
13Abnormality of glycine metabolism (HP:0010895)4.28001981
14Abnormality of serine family amino acid metabolism (HP:0010894)4.28001981
15Hyperammonemia (HP:0001987)4.24966106
16Complement deficiency (HP:0004431)4.24365645
17Hydroxyprolinuria (HP:0003080)3.96240430
18Abnormality of proline metabolism (HP:0010907)3.96240430
19Fat malabsorption (HP:0002630)3.95777890
20Abnormality of sulfur amino acid metabolism (HP:0004339)3.92074480
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.88388110
22Abnormality of pyrimidine metabolism (HP:0004353)3.86193285
23Abnormality of methionine metabolism (HP:0010901)3.76033709
24Epidermoid cyst (HP:0200040)3.70694760
25Amelogenesis imperfecta (HP:0000705)3.56411495
26Hypoalphalipoproteinemia (HP:0003233)3.55910624
27Abnormality of aspartate family amino acid metabolism (HP:0010899)3.50617644
28Joint hemorrhage (HP:0005261)3.41785834
29Ketosis (HP:0001946)3.40901808
30Abnormality of glutamine family amino acid metabolism (HP:0010902)3.34005497
31Rectal prolapse (HP:0002035)3.30025845
32Abnormality of serum amino acid levels (HP:0003112)3.26712823
33Ileus (HP:0002595)3.26416146
34Abnormality of urine glucose concentration (HP:0011016)3.26401015
35Glycosuria (HP:0003076)3.26401015
36Abnormality of the common coagulation pathway (HP:0010990)3.24952903
37Abnormality of complement system (HP:0005339)3.17294389
38Steatorrhea (HP:0002570)3.14050526
39Myocardial infarction (HP:0001658)3.12211379
40Abnormal pancreas size (HP:0012094)3.04806920
41Alopecia of scalp (HP:0002293)3.03357638
42Abnormality of the renal cortex (HP:0011035)3.00950566
43Abnormality of the intrinsic pathway (HP:0010989)3.00077659
44Pancreatic cysts (HP:0001737)2.94711158
45Potter facies (HP:0002009)2.92637709
46Facial shape deformation (HP:0011334)2.92637709
47Congenital sensorineural hearing impairment (HP:0008527)2.89586705
48Hypoglycemic coma (HP:0001325)2.89342351
49Decreased circulating renin level (HP:0003351)2.87330972
50Exocrine pancreatic insufficiency (HP:0001738)2.85561484
51Hyperventilation (HP:0002883)2.80094344
52Hypercholesterolemia (HP:0003124)2.78196424
53Turricephaly (HP:0000262)2.77713817
54Facial hemangioma (HP:0000329)2.72161880
55Abnormality of vitamin metabolism (HP:0100508)2.72105916
56Pustule (HP:0200039)2.71933344
57Conjugated hyperbilirubinemia (HP:0002908)2.70880982
58Abnormality of nucleobase metabolism (HP:0010932)2.69899493
59Gout (HP:0001997)2.68471603
60Delayed CNS myelination (HP:0002188)2.65519266
61Spastic diplegia (HP:0001264)2.60467251
62Malnutrition (HP:0004395)2.59133357
63Pigmentary retinal degeneration (HP:0001146)2.58764066
64Abnormality of vitamin B metabolism (HP:0004340)2.57763957
65Congenital stationary night blindness (HP:0007642)2.57101626
66Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.48143705
67Ketoacidosis (HP:0001993)2.47368689
68Spontaneous abortion (HP:0005268)2.45015530
69Lethargy (HP:0001254)2.44303992
70Abnormal biliary tract morphology (HP:0012440)2.43627703
71Abnormality of fatty-acid metabolism (HP:0004359)2.41634351
72Cerebral palsy (HP:0100021)2.39718862
73Abnormality of the vitamin B12 metabolism (HP:0004341)2.39668198
74Rib fusion (HP:0000902)2.39372181
75Polycythemia (HP:0001901)2.38766107
76Glomerulonephritis (HP:0000099)2.38521938
77Irritability (HP:0000737)2.37936895
78Hypoproteinemia (HP:0003075)2.35826326
79Hyperbilirubinemia (HP:0002904)2.35547294
80Abnormality of alanine metabolism (HP:0010916)2.35069979
81Hyperalaninemia (HP:0003348)2.35069979
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35069979
83Stomach cancer (HP:0012126)2.31762939
84Hepatocellular carcinoma (HP:0001402)2.31544534
85Impulsivity (HP:0100710)2.29302604
86Azoospermia (HP:0000027)2.27673257
87Enlarged kidneys (HP:0000105)2.25832085
88Tubular atrophy (HP:0000092)2.25149625
89Methylmalonic aciduria (HP:0012120)2.25127406
90Vaginal fistula (HP:0004320)2.24636781
91Alkalosis (HP:0001948)2.19169189
92Hypoplasia of the uterus (HP:0000013)2.18980375
93Decreased central vision (HP:0007663)2.17307273
94Hypochromic anemia (HP:0001931)2.16570407
95Pancreatitis (HP:0001733)2.16093014
96Abolished electroretinogram (ERG) (HP:0000550)2.13994436
97Rectovaginal fistula (HP:0000143)2.13736187
98Rectal fistula (HP:0100590)2.13736187
99Abnormal hemoglobin (HP:0011902)2.13563245
100Esophageal varix (HP:0002040)2.13286530
101Abnormality of lateral ventricle (HP:0030047)2.13178479
102Aplasia/Hypoplasia of the tibia (HP:0005772)2.12965181
103Abnormality of purine metabolism (HP:0004352)2.11752597
104Abnormality of the lower motor neuron (HP:0002366)2.11673487
105Abnormality of chloride homeostasis (HP:0011422)2.06833742
106Hypoalbuminemia (HP:0003073)2.06640422
107Abnormal albumin level (HP:0012116)2.06640422
108Skin nodule (HP:0200036)2.04916949
109Attenuation of retinal blood vessels (HP:0007843)2.04049966
110Abnormal cartilage morphology (HP:0002763)2.04030337
111Pendular nystagmus (HP:0012043)2.03201966
112Male infertility (HP:0003251)2.00529912
113Proximal tubulopathy (HP:0000114)2.00288403
114Concave nail (HP:0001598)2.00096796
115Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.99838828
116Metabolic alkalosis (HP:0200114)1.98535407
117Stenosis of the external auditory canal (HP:0000402)1.97573882
118Gonadotropin excess (HP:0000837)1.97511395
119Dicarboxylic aciduria (HP:0003215)1.97476578
120Abnormality of dicarboxylic acid metabolism (HP:0010995)1.97476578
121Hypokalemia (HP:0002900)1.97466901
122Hyperglycemia (HP:0003074)1.96938002
123Large for gestational age (HP:0001520)1.96603105
124Abnormality of renin-angiotensin system (HP:0000847)1.95150882
125Chorioretinal atrophy (HP:0000533)1.94391264
126Fair hair (HP:0002286)1.94183622
127Renal cortical cysts (HP:0000803)1.93865891
128Pancreatic islet-cell hyperplasia (HP:0004510)1.93641393
129Coronal craniosynostosis (HP:0004440)1.93161053
130Opisthotonus (HP:0002179)1.93048459
131Abnormal enzyme/coenzyme activity (HP:0012379)1.92817645
132Hyperaldosteronism (HP:0000859)1.92580924
133Abnormality of the renal medulla (HP:0100957)1.92155403
134Confusion (HP:0001289)1.92066094
135Metabolic acidosis (HP:0001942)1.91657184
136Acanthocytosis (HP:0001927)1.89730504
137Late onset (HP:0003584)1.88956257
138Chronic hepatic failure (HP:0100626)1.86460275
139Intestinal fistula (HP:0100819)1.84637169
140Acute hepatic failure (HP:0006554)1.83842577
141Ulnar bowing (HP:0003031)1.82869777
142Abnormality of endocrine pancreas physiology (HP:0012093)1.82639534
143Abnormality of the pancreatic islet cells (HP:0006476)1.82639534
144Hypothermia (HP:0002045)1.82217947
145Osteomalacia (HP:0002749)1.82047671
146Parakeratosis (HP:0001036)1.81394094
147Congenital, generalized hypertrichosis (HP:0004540)1.81356044
148True hermaphroditism (HP:0010459)1.79420315
149Megaloblastic anemia (HP:0001889)1.79302334
150Nephritis (HP:0000123)1.77813375
151Male pseudohermaphroditism (HP:0000037)1.77648985
152Aplasia/hypoplasia of the uterus (HP:0008684)1.77626942
153Aplasia/hypoplasia of the humerus (HP:0006507)1.76515791
154Short humerus (HP:0005792)1.76159066
155Abnormality of midbrain morphology (HP:0002418)1.76135081
156Molar tooth sign on MRI (HP:0002419)1.76135081
157Absent radius (HP:0003974)1.75761459
158Abnormality of alkaline phosphatase activity (HP:0004379)1.74228691
159Pseudobulbar signs (HP:0002200)1.73043895
160Poikiloderma (HP:0001029)1.72421269
161Squamous cell carcinoma (HP:0002860)1.71017831
162Dysautonomia (HP:0002459)1.70689000
163Neonatal onset (HP:0003623)1.70417781
164Aplasia/Hypoplasia involving the musculature (HP:0001460)1.70405863
165Tongue fasciculations (HP:0001308)1.70079601
166Capillary hemangiomas (HP:0005306)1.69926460
167Breast hypoplasia (HP:0003187)1.68806720
168Vascular calcification (HP:0004934)1.67730065
169Rickets (HP:0002748)1.67260753
170Poikilocytosis (HP:0004447)1.66599108

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK25.05235304
2FRK4.61222469
3ICK4.42178565
4BMPR1B3.74154881
5MAP3K63.49698403
6BCKDK3.49378537
7MAPK153.46520991
8DDR23.29299088
9PINK13.13489502
10ZAK3.03924311
11AKT32.78855696
12LATS12.61966010
13MAP3K112.50948142
14NLK2.48778264
15LATS22.41424426
16GRK12.26369419
17STK392.24950423
18TNIK2.13798894
19INSRR2.11852229
20ADRBK22.08357829
21TIE12.08000640
22OXSR12.05521134
23TYRO32.03849443
24WNK31.87995831
25CDK71.87119628
26MATK1.86284681
27STK38L1.85488105
28WEE11.84856779
29EPHA21.84670764
30MAPK111.75230061
31PRKG21.71163136
32FGFR41.68143940
33CASK1.68034268
34CDK121.65006007
35FGR1.63095311
36WNK41.61842359
37CDK61.59292920
38CSK1.58790196
39NEK21.58647658
40DYRK1B1.55101200
41SIK11.50669418
42ERBB41.45544129
43NUAK11.45225771
44BMX1.44721466
45DYRK31.39916498
46PDGFRA1.39295695
47TTK1.38894261
48PLK11.38314521
49STK31.34476168
50CHEK21.33957968
51BUB11.33586494
52DAPK11.32914500
53TLK11.32594889
54MAP4K21.30790819
55NEK11.25858915
56PIM11.23796396
57FER1.23363140
58MST41.22013360
59ERN11.19658003
60EIF2AK31.14632798
61DAPK21.13872791
62CDK41.12581796
63PIK3CA1.11986533
64GSK3A1.11660516
65TGFBR11.10866255
66MTOR1.10816424
67PRKD21.10550609
68PRKAA11.07247870
69KDR1.04182486
70PIM20.99660173
71YES10.95881255
72CDK80.93636791
73ACVR1B0.92093667
74PRKCE0.91291685
75TAF10.90124290
76BRSK20.88840329
77FLT30.84710806
78MKNK20.84155203
79TRIB30.83439948
80PRKAA20.80665866
81CSNK1G10.79028896
82TAOK30.78584102
83ADRBK10.78483123
84TAOK20.76135249
85MAP3K100.75816948
86PIK3CG0.74274743
87FGFR20.73449676
88MAP3K40.71194950
89MAP3K20.68742151
90AURKB0.68674607
91PAK30.64948498
92EPHA30.64794062
93EIF2AK10.63824264
94CDK20.63775353
95DYRK20.62886279
96AURKA0.61831600
97IRAK10.60524374
98MUSK0.60271950
99RPS6KL10.59081082
100RPS6KC10.59081082
101TXK0.58168838
102RPS6KB20.58066456
103CHEK10.57440512
104STK380.54600347
105VRK10.52634856
106MAPKAPK30.52404645
107STK110.52277091
108RPS6KA10.51961198
109CSNK2A10.51816166
110STK240.50989201
111CSNK1E0.50779277
112ABL20.49970179
113MET0.49877514
114UHMK10.49841730
115ATR0.49644993
116CDC70.49604800
117ATM0.47655915
118RPS6KA60.47579838
119PLK30.47116214
120PKN20.46631903
121CSNK2A20.46462408
122MAPK40.45451038
123PRKCZ0.44949652
124PRKACG0.44081756
125PNCK0.43044878
126MAP3K80.42831599
127CDC42BPA0.42495256
128MAP3K120.42210411
129CAMK2G0.41732705
130PRKCQ0.41730103
131PRKCG0.41692680
132CSNK1A10.41628942
133MAP3K30.41563166
134PDK40.41070076
135PDK30.41070076
136MAP2K20.40626394
137MAPK10.40047038
138TEC0.39239062
139EPHB20.39134920
140JAK20.39075330
141PRKCA0.39030214
142MELK0.38546854
143CSNK1A1L0.37585794
144PRKCI0.37408182
145PDK20.36699922
146RAF10.36386708
147CDK10.36284057
148* PRKACA0.35989144
149MST1R0.35459657
150TRPM70.33873694
151RPS6KA50.33589529
152TAOK10.33271612
153ERBB20.32748312
154SRPK10.32560703
155PTK20.32556212
156MAPK30.32484597
157CAMK2A0.32116261
158NME10.32009791
159EGFR0.31860723
160TRIM280.31135387
161IGF1R0.30784957
162AKT20.30735956
163CSNK1D0.29364921
164TSSK60.27696817
165MAP2K10.27035271
166PRKG10.26012479
167ROCK10.24695252
168PDPK10.24550729
169MAPK130.24534217
170PHKG10.24195794
171PHKG20.24195794
172IKBKB0.23472152
173MAP2K60.22999647
174NTRK30.22006147
175PRKD30.19843803
176CSNK1G20.17109586

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.85242552
2Nitrogen metabolism_Homo sapiens_hsa009103.26033393
3Arginine biosynthesis_Homo sapiens_hsa002203.03812606
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.97543122
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.96877426
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.81183127
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.64574867
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.33020492
9Tryptophan metabolism_Homo sapiens_hsa003802.31357704
10Complement and coagulation cascades_Homo sapiens_hsa046102.25282366
11Vitamin B6 metabolism_Homo sapiens_hsa007502.13972140
12Pancreatic secretion_Homo sapiens_hsa049722.13910974
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.12014632
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.04900186
15Fatty acid degradation_Homo sapiens_hsa000712.02747862
16Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.94718041
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.92757879
18Folate biosynthesis_Homo sapiens_hsa007901.92550976
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.90397400
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.89621965
21Fatty acid metabolism_Homo sapiens_hsa012121.86696069
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.86341598
23Fatty acid biosynthesis_Homo sapiens_hsa000611.83523708
24Biosynthesis of amino acids_Homo sapiens_hsa012301.74383599
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.73432472
26Butanoate metabolism_Homo sapiens_hsa006501.70091415
27Selenocompound metabolism_Homo sapiens_hsa004501.69525367
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.68396306
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.62789070
30Peroxisome_Homo sapiens_hsa041461.62707463
31Protein digestion and absorption_Homo sapiens_hsa049741.61175851
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.58685861
33Chemical carcinogenesis_Homo sapiens_hsa052041.58208014
34Arachidonic acid metabolism_Homo sapiens_hsa005901.55067804
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.53737270
36Propanoate metabolism_Homo sapiens_hsa006401.52945240
37Histidine metabolism_Homo sapiens_hsa003401.51192844
38beta-Alanine metabolism_Homo sapiens_hsa004101.48990485
39Arginine and proline metabolism_Homo sapiens_hsa003301.48891006
40PPAR signaling pathway_Homo sapiens_hsa033201.48742078
41Retinol metabolism_Homo sapiens_hsa008301.43490882
42Fat digestion and absorption_Homo sapiens_hsa049751.43044033
43Sulfur relay system_Homo sapiens_hsa041221.37403330
44One carbon pool by folate_Homo sapiens_hsa006701.32754701
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30268576
46Caffeine metabolism_Homo sapiens_hsa002321.30260584
47Phototransduction_Homo sapiens_hsa047441.29299204
48Staphylococcus aureus infection_Homo sapiens_hsa051501.27447780
49Ether lipid metabolism_Homo sapiens_hsa005651.26233451
50Steroid biosynthesis_Homo sapiens_hsa001001.26205729
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23898435
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.17951064
53Phenylalanine metabolism_Homo sapiens_hsa003601.17797336
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17333875
55Bile secretion_Homo sapiens_hsa049761.14661675
56Ovarian steroidogenesis_Homo sapiens_hsa049131.11550188
57Starch and sucrose metabolism_Homo sapiens_hsa005001.11277251
58Carbon metabolism_Homo sapiens_hsa012001.11013998
59Lysine degradation_Homo sapiens_hsa003101.08016524
60Renin-angiotensin system_Homo sapiens_hsa046141.07775836
61Mineral absorption_Homo sapiens_hsa049781.06429901
62Vitamin digestion and absorption_Homo sapiens_hsa049771.06026537
63Tyrosine metabolism_Homo sapiens_hsa003501.05334692
64Pyruvate metabolism_Homo sapiens_hsa006201.03920816
65Mismatch repair_Homo sapiens_hsa034301.02620970
66Fatty acid elongation_Homo sapiens_hsa000621.02242157
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.98396510
68ABC transporters_Homo sapiens_hsa020100.90196229
69Sphingolipid metabolism_Homo sapiens_hsa006000.88465291
70Glutathione metabolism_Homo sapiens_hsa004800.87336113
71Base excision repair_Homo sapiens_hsa034100.85193238
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84421170
73* Maturity onset diabetes of the young_Homo sapiens_hsa049500.82056541
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81893827
75Glycerolipid metabolism_Homo sapiens_hsa005610.80294091
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80205300
77Pentose phosphate pathway_Homo sapiens_hsa000300.76470821
78Sulfur metabolism_Homo sapiens_hsa009200.71626630
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71011407
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68437640
81Fructose and mannose metabolism_Homo sapiens_hsa000510.66088136
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64942939
83RNA transport_Homo sapiens_hsa030130.64822457
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63144965
85DNA replication_Homo sapiens_hsa030300.62839805
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51127264
87Metabolic pathways_Homo sapiens_hsa011000.49461468
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46644779
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44042584
90Galactose metabolism_Homo sapiens_hsa000520.42778118
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39297526
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.37822174
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.37067853
94Nucleotide excision repair_Homo sapiens_hsa034200.36472798
95Serotonergic synapse_Homo sapiens_hsa047260.34178029
96Circadian rhythm_Homo sapiens_hsa047100.33757885
97Linoleic acid metabolism_Homo sapiens_hsa005910.32616701
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30592666
99mTOR signaling pathway_Homo sapiens_hsa041500.28836443
100Pyrimidine metabolism_Homo sapiens_hsa002400.28810106
101Dorso-ventral axis formation_Homo sapiens_hsa043200.27927820
102p53 signaling pathway_Homo sapiens_hsa041150.27393934
103mRNA surveillance pathway_Homo sapiens_hsa030150.24432420
104Taste transduction_Homo sapiens_hsa047420.24370575
105Fanconi anemia pathway_Homo sapiens_hsa034600.23214363
106Nicotine addiction_Homo sapiens_hsa050330.22506225
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22032195
108RNA polymerase_Homo sapiens_hsa030200.22015518
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21809091
110Spliceosome_Homo sapiens_hsa030400.21774623
111Prion diseases_Homo sapiens_hsa050200.20989634
112Homologous recombination_Homo sapiens_hsa034400.20885369
113AMPK signaling pathway_Homo sapiens_hsa041520.20379013
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19994347
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19735210
116Cell cycle_Homo sapiens_hsa041100.19640768
117Oxidative phosphorylation_Homo sapiens_hsa001900.19545123
118Regulation of autophagy_Homo sapiens_hsa041400.18883232
119Protein export_Homo sapiens_hsa030600.18071497
120Asthma_Homo sapiens_hsa053100.17237078
121Thyroid hormone synthesis_Homo sapiens_hsa049180.16722763
122Insulin secretion_Homo sapiens_hsa049110.13777078
123Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.13561856
124Aldosterone synthesis and secretion_Homo sapiens_hsa049250.12170931
125Bladder cancer_Homo sapiens_hsa052190.10707284
126Hippo signaling pathway_Homo sapiens_hsa043900.10591501
127Notch signaling pathway_Homo sapiens_hsa043300.10350494
128TGF-beta signaling pathway_Homo sapiens_hsa043500.07921665
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.07860048
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.07842052

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