NRADDP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of protein homooligomerization (GO:0032464)5.13186507
2leukocyte aggregation (GO:0070486)5.11991664
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.05497003
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.05497003
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.05497003
6modulation by symbiont of host immune response (GO:0052553)5.05497003
7positive regulation by symbiont of host defense response (GO:0052509)5.05497003
8modulation by symbiont of host defense response (GO:0052031)5.05497003
9positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.97813250
10positive regulation of gamma-delta T cell activation (GO:0046645)4.55239500
11immunoglobulin mediated immune response (GO:0016064)4.51270103
12histone H3-K4 trimethylation (GO:0080182)4.47561660
13response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.19140956
14response to host immune response (GO:0052572)4.19140956
15response to peptidoglycan (GO:0032494)4.06441798
16glial cell proliferation (GO:0014009)3.95900683
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.92568109
18negative regulation of cell killing (GO:0031342)3.92568109
19response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.92089763
20response to host (GO:0075136)3.92089763
21response to host defenses (GO:0052200)3.92089763
22defense response to protozoan (GO:0042832)3.85322991
23phosphatidylglycerol biosynthetic process (GO:0006655)3.81936323
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.79650999
25positive regulation of interferon-alpha production (GO:0032727)3.76530861
26neutrophil activation involved in immune response (GO:0002283)3.76277737
27macrophage activation involved in immune response (GO:0002281)3.75320084
28peptidyl-lysine trimethylation (GO:0018023)3.73240552
29B cell mediated immunity (GO:0019724)3.71960503
30positive regulation of B cell differentiation (GO:0045579)3.68463130
31detection of other organism (GO:0098543)3.67378471
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.63560295
33regulation of interferon-alpha production (GO:0032647)3.63400336
34detection of bacterium (GO:0016045)3.62756750
35positive thymic T cell selection (GO:0045059)3.59064566
36antigen processing and presentation of endogenous antigen (GO:0019883)3.58878961
37regulation of interferon-beta biosynthetic process (GO:0045357)3.46283788
38response to protozoan (GO:0001562)3.44845233
39Rap protein signal transduction (GO:0032486)3.35993473
40response to muramyl dipeptide (GO:0032495)3.35844896
41regulation of alpha-beta T cell proliferation (GO:0046640)3.33636554
42antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.32271279
43regulation of B cell receptor signaling pathway (GO:0050855)3.31606824
44negative regulation of interleukin-12 production (GO:0032695)3.30925324
45adaptation of signaling pathway (GO:0023058)3.28190070
46positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.27050828
47regulation of gamma-delta T cell activation (GO:0046643)3.25390747
48cellular extravasation (GO:0045123)3.22756507
49negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.20446664
50respiratory burst (GO:0045730)3.19554365
51neutrophil activation (GO:0042119)3.13334361
52positive regulation of interleukin-10 production (GO:0032733)3.12870423
53myeloid cell activation involved in immune response (GO:0002275)3.11287812
54positive T cell selection (GO:0043368)3.10877849
55tolerance induction (GO:0002507)3.08394118
56negative regulation of erythrocyte differentiation (GO:0045647)3.07696898
57leukocyte migration involved in inflammatory response (GO:0002523)3.06774165
58regulation of B cell differentiation (GO:0045577)3.05832576
59mitochondrial genome maintenance (GO:0000002)3.04806229
60detection of external biotic stimulus (GO:0098581)3.04530873
61regulation of interferon-beta production (GO:0032648)3.02790887
62NIK/NF-kappaB signaling (GO:0038061)3.01422841
63positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.00469408
64cellular response to virus (GO:0098586)2.97917057
65antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.96675990
66G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.96225184
67regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.96138168
68regulation of gamma-delta T cell differentiation (GO:0045586)2.94577486
69regulation of protein homooligomerization (GO:0032462)2.94159446
70B cell receptor signaling pathway (GO:0050853)2.93925410
71regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.93368167
72regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.92605866
73regulation of mast cell degranulation (GO:0043304)2.90515492
74negative regulation of lymphocyte mediated immunity (GO:0002707)2.89748843
75interferon-gamma production (GO:0032609)2.88710729
76neural tube formation (GO:0001841)2.87669631
77positive regulation of interferon-beta production (GO:0032728)2.86938687
78T cell selection (GO:0045058)2.86794978
79granulocyte activation (GO:0036230)2.86466989
80regulation of memory T cell differentiation (GO:0043380)2.85222543
81negative thymic T cell selection (GO:0045060)2.85102598
82peristalsis (GO:0030432)2.84516829
83peptidyl-lysine methylation (GO:0018022)2.83727919
84positive regulation of protein oligomerization (GO:0032461)2.81038242
85thymic T cell selection (GO:0045061)2.77932317
86positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.76496544
87type I interferon signaling pathway (GO:0060337)2.75405432
88cellular response to type I interferon (GO:0071357)2.75405432
89positive regulation of interleukin-2 production (GO:0032743)2.75217254
90detection of molecule of bacterial origin (GO:0032490)2.75195355
91negative regulation of interleukin-6 production (GO:0032715)2.73248269
92response to type I interferon (GO:0034340)2.72401828
93negative regulation of T cell mediated immunity (GO:0002710)2.67275340
94purinergic nucleotide receptor signaling pathway (GO:0035590)2.66792289
95regulation of type I interferon-mediated signaling pathway (GO:0060338)2.66775792
96germinal center formation (GO:0002467)2.65207557
97negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.64147325
98B cell homeostasis (GO:0001782)2.63225735
99negative T cell selection (GO:0043383)2.62821843
100limb bud formation (GO:0060174)2.62708019

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.67847552
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.30440736
3VDR_21846776_ChIP-Seq_THP-1_Human3.60480466
4MYC_22102868_ChIP-Seq_BL_Human3.13064012
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.96847784
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.88255790
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.83000240
8VDR_24763502_ChIP-Seq_THP-1_Human2.76984940
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.75083675
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.52222254
11MAF_26560356_Chip-Seq_TH1_Human2.51674731
12SCL_19346495_ChIP-Seq_HPC-7_Human2.51536550
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.41811805
14TCF7_22412390_ChIP-Seq_EML_Mouse2.37874129
15* UTX_26944678_Chip-Seq_JUKART_Human2.31418944
16E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.30102435
17SPI1_23547873_ChIP-Seq_NB4_Human2.28169790
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.27993486
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.26866744
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.12060921
21KDM2B_26808549_Chip-Seq_DND41_Human2.11785432
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.06318224
23* MAF_26560356_Chip-Seq_TH2_Human2.02733681
24IRF8_27001747_Chip-Seq_BMDM_Mouse2.02036681
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.01975280
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.99465374
27RUNX1_22412390_ChIP-Seq_EML_Mouse1.97646367
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96891104
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.94013284
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91180513
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.90142606
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.88256510
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82769917
34* MYB_26560356_Chip-Seq_TH2_Human1.78268497
35SPI1_23127762_ChIP-Seq_K562_Human1.75569258
36MYB_26560356_Chip-Seq_TH1_Human1.74725173
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.74679985
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.73651009
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.58993318
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58273580
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57143457
42BCOR_27268052_Chip-Seq_Bcells_Human1.56411496
43P68_20966046_ChIP-Seq_HELA_Human1.54232784
44NCOR1_26117541_ChIP-Seq_K562_Human1.52974114
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.50475135
46* LXR_22292898_ChIP-Seq_THP-1_Human1.46691740
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44318246
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.44121925
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.43900195
50STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.41468202
51KDM2B_26808549_Chip-Seq_JURKAT_Human1.41268939
52RUNX_20019798_ChIP-Seq_JUKART_Human1.40578351
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.39569593
54RACK7_27058665_Chip-Seq_MCF-7_Human1.39482380
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38043496
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.35305178
57GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.33496577
58BCL6_27268052_Chip-Seq_Bcells_Human1.33251007
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33041776
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32820103
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31827952
62ELF1_20517297_ChIP-Seq_JURKAT_Human1.31716757
63GATA3_27048872_Chip-Seq_THYMUS_Human1.31139741
64CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23571679
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22640226
66PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20454078
67CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17491134
68GATA1_19941827_ChIP-Seq_MEL_Mouse1.17383153
69FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16189091
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16000911
71CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13831374
72GATA1_22025678_ChIP-Seq_K562_Human1.11333564
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10308322
74GATA1_19941826_ChIP-Seq_K562_Human1.09580682
75P300_27268052_Chip-Seq_Bcells_Human1.09482672
76E2F1_20622854_ChIP-Seq_HELA_Human1.09152244
77SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07970050
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06868224
79CTCF_21964334_ChIP-Seq_BJAB-B_Human1.06466790
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05872376
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04586520
82SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.03449550
83CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02522791
84PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00487251
85IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00427869
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00018123
87SA1_27219007_Chip-Seq_ERYTHROID_Human0.99264779
88SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99250420
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99203254
90CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98475187
91PHF8_20622854_ChIP-Seq_HELA_Human0.98084708
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97509639
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96626234
94GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96174432
95PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95843452
96CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95045109
97RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94819818
98PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90906796
99GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89142898
100CIITA_25753668_ChIP-Seq_RAJI_Human0.88806577

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.53853084
2MP0003436_decreased_susceptibility_to3.52788272
3MP0003724_increased_susceptibility_to3.08805943
4MP0005671_abnormal_response_to2.88438179
5MP0001800_abnormal_humoral_immune2.82800011
6MP0003172_abnormal_lysosome_physiology2.72118699
7MP0001835_abnormal_antigen_presentation2.69589905
8MP0003763_abnormal_thymus_physiology2.55679273
9MP0005000_abnormal_immune_tolerance2.51564504
10MP0005025_abnormal_response_to2.49094782
11MP0002419_abnormal_innate_immunity2.45435431
12MP0000685_abnormal_immune_system2.39779009
13MP0002723_abnormal_immune_serum2.35780267
14MP0002132_abnormal_respiratory_system2.33442582
15MP0002452_abnormal_antigen_presenting2.33280289
16MP0002420_abnormal_adaptive_immunity2.31813072
17MP0001819_abnormal_immune_cell2.28610573
18MP0000015_abnormal_ear_pigmentation2.20703729
19MP0005464_abnormal_platelet_physiology2.19996560
20MP0009278_abnormal_bone_marrow2.11558199
21MP0002398_abnormal_bone_marrow2.10672723
22MP0009333_abnormal_splenocyte_physiolog2.02198943
23MP0009785_altered_susceptibility_to2.00097191
24MP0001790_abnormal_immune_system1.99137797
25MP0005387_immune_system_phenotype1.99137797
26MP0002148_abnormal_hypersensitivity_rea1.85633895
27MP0008260_abnormal_autophagy1.84843600
28MP0000716_abnormal_immune_system1.81234175
29MP0000689_abnormal_spleen_morphology1.78545518
30MP0008057_abnormal_DNA_replication1.73849533
31MP0003828_pulmonary_edema1.73084475
32MP0000703_abnormal_thymus_morphology1.67978968
33MP0010155_abnormal_intestine_physiology1.65972516
34MP0000490_abnormal_crypts_of1.65781372
35MP0005075_abnormal_melanosome_morpholog1.63919553
36MP0001986_abnormal_taste_sensitivity1.62098507
37MP0002405_respiratory_system_inflammati1.61512802
38MP0004381_abnormal_hair_follicle1.60660216
39MP0008007_abnormal_cellular_replicative1.60541951
40MP0002722_abnormal_immune_system1.59730104
41MP0002429_abnormal_blood_cell1.58126520
42MP0004947_skin_inflammation1.57838870
43MP0002163_abnormal_gland_morphology1.54760421
44MP0004782_abnormal_surfactant_physiolog1.50779088
45MP0005670_abnormal_white_adipose1.47619133
46MP0005083_abnormal_biliary_tract1.46412795
47MP0001845_abnormal_inflammatory_respons1.45919111
48MP0005397_hematopoietic_system_phenotyp1.45851377
49MP0001545_abnormal_hematopoietic_system1.45851377
50MP0003183_abnormal_peptide_metabolism1.40554715
51MP0000858_altered_metastatic_potential1.39068991
52MP0005377_hearing/vestibular/ear_phenot1.38635944
53MP0003878_abnormal_ear_physiology1.38635944
54MP0001533_abnormal_skeleton_physiology1.32751725
55MP0008469_abnormal_protein_level1.31716129
56MP0005310_abnormal_salivary_gland1.29268815
57MP0002019_abnormal_tumor_incidence1.21948766
58MP0001873_stomach_inflammation1.17150990
59MP0003300_gastrointestinal_ulcer1.15685301
60MP0001663_abnormal_digestive_system1.14626060
61MP0001853_heart_inflammation1.13215828
62MP0004883_abnormal_blood_vessel1.12413882
63MP0005174_abnormal_tail_pigmentation1.10364847
64MP0003806_abnormal_nucleotide_metabolis1.05227841
65MP0000371_diluted_coat_color1.04872508
66MP0006082_CNS_inflammation1.03777672
67MP0009764_decreased_sensitivity_to1.01942172
68MP0001851_eye_inflammation1.00893082
69MP0002396_abnormal_hematopoietic_system1.00882621
70MP0009840_abnormal_foam_cell0.99519837
71MP0003866_abnormal_defecation0.98543260
72MP0003191_abnormal_cellular_cholesterol0.96481751
73MP0003786_premature_aging0.94724441
74MP0002138_abnormal_hepatobiliary_system0.93792866
75MP0000538_abnormal_urinary_bladder0.92832275
76MP0002998_abnormal_bone_remodeling0.89676967
77MP0004858_abnormal_nervous_system0.89190754
78MP0000516_abnormal_urinary_system0.86289787
79MP0005367_renal/urinary_system_phenotyp0.86289787
80MP0004808_abnormal_hematopoietic_stem0.84068132
81MP0003111_abnormal_nucleus_morphology0.81937066
82MP0008058_abnormal_DNA_repair0.77466142
83MP0005319_abnormal_enzyme/_coenzyme0.76426037
84MP0005451_abnormal_body_composition0.75094787
85MP0003448_altered_tumor_morphology0.73708315
86MP0002166_altered_tumor_susceptibility0.71887078
87MP0002693_abnormal_pancreas_physiology0.71861853
88MP0001529_abnormal_vocalization0.69986894
89MP0000465_gastrointestinal_hemorrhage0.68666222
90MP0005666_abnormal_adipose_tissue0.66922325
91MP0003136_yellow_coat_color0.65552190
92MP0000313_abnormal_cell_death0.64308801
93MP0000470_abnormal_stomach_morphology0.63776761
94MP0003221_abnormal_cardiomyocyte_apopto0.63718811
95MP0003077_abnormal_cell_cycle0.63272640
96MP0003091_abnormal_cell_migration0.61365911
97MP0006035_abnormal_mitochondrial_morpho0.61088602
98MP0006036_abnormal_mitochondrial_physio0.60928447
99MP0003656_abnormal_erythrocyte_physiolo0.60814444
100MP0002282_abnormal_trachea_morphology0.59961489

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.03630063
2Elevated erythrocyte sedimentation rate (HP:0003565)4.91351487
3Stomatitis (HP:0010280)4.68874512
4Agammaglobulinemia (HP:0004432)4.37798502
5Facial hemangioma (HP:0000329)4.30537220
6Recurrent abscess formation (HP:0002722)4.27662524
7Recurrent bacterial skin infections (HP:0005406)4.01293953
8Cellulitis (HP:0100658)3.86811326
9Abnormality of macrophages (HP:0004311)3.79006611
10Myositis (HP:0100614)3.74863122
11Meningitis (HP:0001287)3.73159970
12Increased IgE level (HP:0003212)3.71591174
13Panhypogammaglobulinemia (HP:0003139)3.68861441
14Recurrent fungal infections (HP:0002841)3.59521797
15Orchitis (HP:0100796)3.40597094
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.31291687
17Retrobulbar optic neuritis (HP:0100654)3.28539121
18Optic neuritis (HP:0100653)3.28539121
19Gastrointestinal infarctions (HP:0005244)3.26219401
20Chronic obstructive pulmonary disease (HP:0006510)3.19096745
21Obstructive lung disease (HP:0006536)3.19096745
22Neonatal respiratory distress (HP:0002643)3.17397358
23Autoimmune hemolytic anemia (HP:0001890)3.11774622
24Slow saccadic eye movements (HP:0000514)3.10593415
25Recurrent cutaneous fungal infections (HP:0011370)3.05177747
26Chronic mucocutaneous candidiasis (HP:0002728)3.05177747
27Recurrent gram-negative bacterial infections (HP:0005420)2.91780112
28Prolonged bleeding time (HP:0003010)2.86552995
29Recurrent viral infections (HP:0004429)2.85328136
30Abnormality of lateral ventricle (HP:0030047)2.80756473
31Granulocytopenia (HP:0001913)2.80663018
32Episodic fever (HP:0001954)2.79494198
33Interstitial pulmonary disease (HP:0006530)2.79153033
34Albinism (HP:0001022)2.77669172
35Mediastinal lymphadenopathy (HP:0100721)2.74988163
36Osteomyelitis (HP:0002754)2.71921276
37Recurrent skin infections (HP:0001581)2.70832715
38Petechiae (HP:0000967)2.67818835
39Sepsis (HP:0100806)2.63091901
40Encephalitis (HP:0002383)2.61653633
41Pustule (HP:0200039)2.54189611
42Verrucae (HP:0200043)2.54164136
43Papilloma (HP:0012740)2.54164136
44Broad alveolar ridges (HP:0000187)2.53224279
45Hemorrhage of the eye (HP:0011885)2.52865640
46Intellectual disability, progressive (HP:0006887)2.50977508
47Severe combined immunodeficiency (HP:0004430)2.48097392
48Gingivitis (HP:0000230)2.47231714
49Chest pain (HP:0100749)2.44484192
50Type I transferrin isoform profile (HP:0003642)2.40339274
51Keratoconjunctivitis sicca (HP:0001097)2.38074880
52Keratitis (HP:0000491)2.36396988
53Poikiloderma (HP:0001029)2.36056662
54Testicular atrophy (HP:0000029)2.33383261
55Hypochromic anemia (HP:0001931)2.32041168
56Delayed CNS myelination (HP:0002188)2.29123366
57Vasculitis (HP:0002633)2.28546086
58Megalencephaly (HP:0001355)2.25091076
59Recurrent pneumonia (HP:0006532)2.22590244
60Ocular albinism (HP:0001107)2.20656371
61Thyroid-stimulating hormone excess (HP:0002925)2.18908517
62Prominent nose (HP:0000448)2.18897507
63Chronic sinusitis (HP:0011109)2.15768334
64Keratoconjunctivitis (HP:0001096)2.13667082
65Autoimmune thrombocytopenia (HP:0001973)2.12626285
66Combined immunodeficiency (HP:0005387)2.09228535
67Urticaria (HP:0001025)2.08976252
68Gastrointestinal dysmotility (HP:0002579)2.08497842
69Inflammation of the large intestine (HP:0002037)2.07703656
70Epistaxis (HP:0000421)2.07033064
71Pulmonary infiltrates (HP:0002113)2.06762336
72Anorexia (HP:0002039)2.04940666
73Gastrointestinal inflammation (HP:0004386)2.03765724
74Increased IgM level (HP:0003496)1.99248513
75Pulmonary fibrosis (HP:0002206)1.99200588
76Ragged-red muscle fibers (HP:0003200)1.98796946
77Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.98495319
78Leukocytosis (HP:0001974)1.98193793
79Recurrent lower respiratory tract infections (HP:0002783)1.97820417
80Colitis (HP:0002583)1.95736745
81Hemoptysis (HP:0002105)1.91060748
82Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.88785241
83Arterial thrombosis (HP:0004420)1.88779696
84Eosinophilia (HP:0001880)1.88069786
85Viral hepatitis (HP:0006562)1.87693155
86Skin ulcer (HP:0200042)1.86710891
87Exercise-induced myalgia (HP:0003738)1.82931094
88Myelodysplasia (HP:0002863)1.76154905
89Lymphopenia (HP:0001888)1.75779854
90B lymphocytopenia (HP:0010976)1.75272067
91Abnormality of B cell number (HP:0010975)1.72996006
92Gingival bleeding (HP:0000225)1.72695008
93Amyloidosis (HP:0011034)1.72497613
94Cutis marmorata (HP:0000965)1.71294102
95Aplasia/Hypoplasia of the thymus (HP:0010515)1.71262675
96Hypergammaglobulinemia (HP:0010702)1.70333255
97High anterior hairline (HP:0009890)1.70211061
98Abnormality of the preputium (HP:0100587)1.69701976
99Purpura (HP:0000979)1.69641140
100Increased serum ferritin (HP:0003281)1.68861224

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.29853449
2RIPK43.24065628
3TYK23.12208309
4MAP4K13.02285732
5TNK22.78054177
6IRAK42.64145319
7ERN12.55989351
8MAP2K32.55078740
9STK102.47561566
10BLK2.32848871
11KSR12.30305675
12IKBKE2.12258022
13GRK62.11840202
14TBK11.98192101
15BTK1.92700663
16FGR1.81021299
17SIK31.78229111
18CSK1.75840037
19ZAP701.72647780
20TEC1.65723714
21MOS1.64382649
22KSR21.61773242
23MAP3K131.57234850
24HCK1.56729860
25ARAF1.52439443
26FES1.46742833
27PRPF4B1.44990892
28SYK1.42390498
29GRK71.36221782
30WEE11.30174683
31TESK21.26690750
32MAP3K31.22194599
33MAP3K11.19507072
34JAK31.19446795
35TGFBR21.18156346
36RAF11.12228414
37MAPK111.08615887
38IKBKB1.07033285
39PDK11.06742130
40MAP4K21.06602278
41MAP2K11.05782807
42PLK41.05137161
43ITK1.04049260
44MATK1.02302900
45LYN0.99334970
46PDPK10.97806184
47PRKD20.95443437
48TXK0.94238686
49ILK0.92934239
50EIF2AK10.92817627
51JAK20.91953102
52MAPK150.85479693
53MAP3K140.83103788
54LCK0.82997356
55DYRK30.81761518
56MAPK120.81600245
57TAOK30.80658970
58TRIB30.78634418
59RPS6KL10.78508832
60RPS6KC10.78508832
61SIK10.77711528
62TLK10.76854237
63MAP3K20.76149923
64MAPKAPK20.74868136
65SIK20.73856071
66SMG10.72352588
67TAOK10.70704584
68MAP3K80.70435867
69RPS6KA20.67859484
70RPS6KA60.65905245
71MAP2K60.65627099
72NME20.65575950
73YES10.64802492
74JAK10.61647627
75IRAK20.58972316
76ERBB20.58794593
77HIPK20.58465524
78CDK40.58405830
79BMX0.57412492
80PRKCD0.55593165
81WNK30.54891121
82CSNK1G20.52375911
83LRRK20.52114670
84EPHB10.49925629
85DYRK1B0.48774076
86IRAK10.48424288
87VRK20.48291726
88PAK10.46327481
89PAK30.45013884
90EPHB20.44804616
91MARK20.42666546
92CSNK1D0.42202053
93PRKD10.39560760
94PRKCQ0.38655143
95PRKCI0.38137929
96MAPK40.38104266
97GRK50.36253310
98MAPK30.36151693
99RPS6KA10.33602834
100PIM10.33144913

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.10039156
2B cell receptor signaling pathway_Homo sapiens_hsa046622.96230162
3Osteoclast differentiation_Homo sapiens_hsa043802.49112648
4Acute myeloid leukemia_Homo sapiens_hsa052212.18039477
5Leishmaniasis_Homo sapiens_hsa051402.08866285
6Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.06241692
7Measles_Homo sapiens_hsa051622.00419899
8Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.95672080
9T cell receptor signaling pathway_Homo sapiens_hsa046601.93529909
10Non-small cell lung cancer_Homo sapiens_hsa052231.86370244
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.84812980
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.82486253
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.65009836
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59844127
15Allograft rejection_Homo sapiens_hsa053301.58563291
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.57344682
17Tuberculosis_Homo sapiens_hsa051521.57123924
18Influenza A_Homo sapiens_hsa051641.52388342
19Staphylococcus aureus infection_Homo sapiens_hsa051501.48740752
20Graft-versus-host disease_Homo sapiens_hsa053321.47551264
21Pancreatic cancer_Homo sapiens_hsa052121.44326679
22Autoimmune thyroid disease_Homo sapiens_hsa053201.40957394
23Chemokine signaling pathway_Homo sapiens_hsa040621.39689369
24DNA replication_Homo sapiens_hsa030301.37820050
25Chronic myeloid leukemia_Homo sapiens_hsa052201.36675965
26Hepatitis C_Homo sapiens_hsa051601.36626096
27Toxoplasmosis_Homo sapiens_hsa051451.36371560
28VEGF signaling pathway_Homo sapiens_hsa043701.35903020
29Renal cell carcinoma_Homo sapiens_hsa052111.34417423
30Herpes simplex infection_Homo sapiens_hsa051681.32484244
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.31007336
32Fanconi anemia pathway_Homo sapiens_hsa034601.29856883
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.28953624
34TNF signaling pathway_Homo sapiens_hsa046681.26166115
35Platelet activation_Homo sapiens_hsa046111.25718835
36Endometrial cancer_Homo sapiens_hsa052131.25667396
37Hepatitis B_Homo sapiens_hsa051611.22291881
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19788561
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.15118177
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.13689335
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.11572523
42Viral myocarditis_Homo sapiens_hsa054161.11287359
43Carbohydrate digestion and absorption_Homo sapiens_hsa049731.07640457
44Apoptosis_Homo sapiens_hsa042101.06572711
45Epstein-Barr virus infection_Homo sapiens_hsa051691.06116900
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05265557
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04909752
48Prolactin signaling pathway_Homo sapiens_hsa049171.02738973
49Base excision repair_Homo sapiens_hsa034101.01589230
50mTOR signaling pathway_Homo sapiens_hsa041501.00630076
51Sphingolipid signaling pathway_Homo sapiens_hsa040710.98804767
52Hematopoietic cell lineage_Homo sapiens_hsa046400.98452638
53Antigen processing and presentation_Homo sapiens_hsa046120.93918623
54Colorectal cancer_Homo sapiens_hsa052100.93619918
55Shigellosis_Homo sapiens_hsa051310.93170306
56Dorso-ventral axis formation_Homo sapiens_hsa043200.91028735
57Viral carcinogenesis_Homo sapiens_hsa052030.89876578
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89042685
59Prostate cancer_Homo sapiens_hsa052150.87859076
60Choline metabolism in cancer_Homo sapiens_hsa052310.87620564
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87377232
62Type I diabetes mellitus_Homo sapiens_hsa049400.86634899
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81935127
64Pertussis_Homo sapiens_hsa051330.80543661
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.80185266
66Other glycan degradation_Homo sapiens_hsa005110.78782649
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.77427344
68FoxO signaling pathway_Homo sapiens_hsa040680.77069688
69Cell cycle_Homo sapiens_hsa041100.76721767
70ABC transporters_Homo sapiens_hsa020100.76011943
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75873019
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.75812732
73Malaria_Homo sapiens_hsa051440.74256123
74Asthma_Homo sapiens_hsa053100.72918969
75Homologous recombination_Homo sapiens_hsa034400.70868275
76Notch signaling pathway_Homo sapiens_hsa043300.69758538
77Glioma_Homo sapiens_hsa052140.67767077
78Olfactory transduction_Homo sapiens_hsa047400.67346312
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.66921400
80Selenocompound metabolism_Homo sapiens_hsa004500.64106008
81Legionellosis_Homo sapiens_hsa051340.63969880
82HTLV-I infection_Homo sapiens_hsa051660.63860006
83Inositol phosphate metabolism_Homo sapiens_hsa005620.62026119
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61470753
85Basal transcription factors_Homo sapiens_hsa030220.60934473
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60533563
87Fructose and mannose metabolism_Homo sapiens_hsa000510.59823983
88N-Glycan biosynthesis_Homo sapiens_hsa005100.59554624
89African trypanosomiasis_Homo sapiens_hsa051430.59426484
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58728684
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58417920
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56059871
93HIF-1 signaling pathway_Homo sapiens_hsa040660.53711625
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52502308
95Endocytosis_Homo sapiens_hsa041440.51519335
96ErbB signaling pathway_Homo sapiens_hsa040120.51344396
97Small cell lung cancer_Homo sapiens_hsa052220.50062442
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47194106
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46678573
100Estrogen signaling pathway_Homo sapiens_hsa049150.45662853

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