NRAS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.77666680
2regulation of centriole replication (GO:0046599)4.72112375
3protein localization to chromosome, centromeric region (GO:0071459)4.52324751
4mitotic chromosome condensation (GO:0007076)4.46688308
5establishment of integrated proviral latency (GO:0075713)4.40340564
6regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.38634830
7protein localization to kinetochore (GO:0034501)4.33458594
8mitotic sister chromatid cohesion (GO:0007064)4.18484716
9Golgi transport vesicle coating (GO:0048200)4.14113842
10COPI coating of Golgi vesicle (GO:0048205)4.14113842
11sequestering of actin monomers (GO:0042989)3.96403102
12cellular protein complex localization (GO:0034629)3.92733575
13sister chromatid segregation (GO:0000819)3.91256439
14mitotic sister chromatid segregation (GO:0000070)3.90656018
15ribosome assembly (GO:0042255)3.78812428
16protein complex localization (GO:0031503)3.78341244
17formation of translation preinitiation complex (GO:0001731)3.75296698
18DNA topological change (GO:0006265)3.74060777
19mitotic nuclear envelope disassembly (GO:0007077)3.52987482
20DNA duplex unwinding (GO:0032508)3.44500340
21regulation of RNA export from nucleus (GO:0046831)3.44306787
22DNA geometric change (GO:0032392)3.34165307
23regulation of mitotic spindle checkpoint (GO:1903504)3.33120072
24regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.33120072
25nuclear envelope disassembly (GO:0051081)3.30849119
26membrane disassembly (GO:0030397)3.30849119
27IMP biosynthetic process (GO:0006188)3.29014681
28regulation of centrosome cycle (GO:0046605)3.26296645
29regulation of translational fidelity (GO:0006450)3.25994840
30regulation of sister chromatid cohesion (GO:0007063)3.25349122
31negative regulation of DNA repair (GO:0045738)3.20049508
32establishment of viral latency (GO:0019043)3.17691877
33viral mRNA export from host cell nucleus (GO:0046784)3.15820574
34peptidyl-arginine omega-N-methylation (GO:0035247)3.14969851
35regulation of centrosome duplication (GO:0010824)3.12634265
36kinetochore organization (GO:0051383)3.11631485
37double-strand break repair via nonhomologous end joining (GO:0006303)3.08429184
38non-recombinational repair (GO:0000726)3.08429184
39positive regulation of chromosome segregation (GO:0051984)3.07960710
40DNA replication initiation (GO:0006270)3.05613112
41folic acid-containing compound biosynthetic process (GO:0009396)3.03556723
42positive regulation of keratinocyte differentiation (GO:0045618)3.03216428
43regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.03138700
44regulation of chromosome segregation (GO:0051983)3.02468801
45purine nucleobase biosynthetic process (GO:0009113)3.00291440
46superoxide anion generation (GO:0042554)2.99075591
47histone H2B ubiquitination (GO:0033523)2.98884743
48regulation of spindle organization (GO:0090224)2.98461402
49pre-miRNA processing (GO:0031054)2.96182441
50nucleobase-containing small molecule interconversion (GO:0015949)2.95483880
51protein export from nucleus (GO:0006611)2.92520983
52IMP metabolic process (GO:0046040)2.91869770
53DNA conformation change (GO:0071103)2.91578240
54regulation of translational termination (GO:0006449)2.88291312
55regulation of mitotic spindle organization (GO:0060236)2.87713772
56peptidyl-arginine methylation (GO:0018216)2.87295778
57peptidyl-arginine N-methylation (GO:0035246)2.87295778
58regulation of nucleobase-containing compound transport (GO:0032239)2.85242831
59DNA replication-independent nucleosome assembly (GO:0006336)2.84787170
60DNA replication-independent nucleosome organization (GO:0034724)2.84787170
61DNA ligation (GO:0006266)2.84042177
62spliceosomal tri-snRNP complex assembly (GO:0000244)2.82534005
63ATP-dependent chromatin remodeling (GO:0043044)2.80316054
64chromosome condensation (GO:0030261)2.80275802
65nucleobase biosynthetic process (GO:0046112)2.79942549
66heterochromatin organization (GO:0070828)2.77934675
67spindle checkpoint (GO:0031577)2.75652141
68kinetochore assembly (GO:0051382)2.74966978
69COPII vesicle coating (GO:0048208)2.73935328
70chromosome segregation (GO:0007059)2.73849937
71RNA stabilization (GO:0043489)2.73013069
72mRNA stabilization (GO:0048255)2.73013069
73telomere maintenance via semi-conservative replication (GO:0032201)2.72872426
74telomere maintenance via recombination (GO:0000722)2.72777632
75CENP-A containing nucleosome assembly (GO:0034080)2.72361035
76negative regulation of chromosome segregation (GO:0051985)2.71934301
77regulation of DNA damage checkpoint (GO:2000001)2.71775797
78regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.70789864
79regulation of mitotic metaphase/anaphase transition (GO:0030071)2.70789864
80negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.70637447
81RNA-dependent DNA replication (GO:0006278)2.70562603
82neutrophil activation involved in immune response (GO:0002283)2.69433228
83mitotic spindle checkpoint (GO:0071174)2.69177207
84DNA replication checkpoint (GO:0000076)2.69087584
85negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.65728879
86negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.65728879
87negative regulation of mitotic sister chromatid segregation (GO:0033048)2.65728879
88negative regulation of mitotic sister chromatid separation (GO:2000816)2.65728879
89negative regulation of sister chromatid segregation (GO:0033046)2.65728879
90mRNA transport (GO:0051028)2.65080237
91negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.64272100
92nuclear envelope organization (GO:0006998)2.63825445
93mitotic recombination (GO:0006312)2.63589133
94regulation of transcription from RNA polymerase I promoter (GO:0006356)2.63415230
95L-serine metabolic process (GO:0006563)2.63143245
96histone arginine methylation (GO:0034969)2.61826333
97protein localization to chromosome (GO:0034502)2.60905177
98regulation of translational initiation (GO:0006446)2.60492767
99regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.59042809
100nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.58868636
101meiotic chromosome segregation (GO:0045132)2.58556050
102regulation of mitotic sister chromatid segregation (GO:0033047)2.58000108
103neural tube formation (GO:0001841)2.57569583
104cell differentiation involved in metanephros development (GO:0072202)2.57466939
105RNA capping (GO:0036260)2.56791510
1067-methylguanosine RNA capping (GO:0009452)2.56791510
107negative regulation of mast cell activation (GO:0033004)2.56117174
108dendritic cell chemotaxis (GO:0002407)2.55524841
1097-methylguanosine mRNA capping (GO:0006370)2.55243445
110establishment of chromosome localization (GO:0051303)2.54308692
111chromatin remodeling at centromere (GO:0031055)2.53298005
112regulation of DNA endoreduplication (GO:0032875)2.50575847
113sympathetic nervous system development (GO:0048485)2.49654116
114poly(A)+ mRNA export from nucleus (GO:0016973)2.49301081
115myoblast migration (GO:0051451)2.47383623
116DNA strand elongation (GO:0022616)2.46378438
117replication fork processing (GO:0031297)2.45344206
118mesenchymal cell differentiation involved in renal system development (GO:2001012)2.44422975
119mesenchymal cell differentiation involved in kidney development (GO:0072161)2.44422975
120proteasome assembly (GO:0043248)2.43585072
121definitive hemopoiesis (GO:0060216)2.42441210
122heart contraction (GO:0060047)2.40645666
123heart process (GO:0003015)2.40645666
124regulation of double-strand break repair via homologous recombination (GO:0010569)2.40374181
125DNA strand elongation involved in DNA replication (GO:0006271)2.40256642
126negative regulation of viral genome replication (GO:0045071)2.40161786
127centriole assembly (GO:0098534)2.39520917
128positive regulation of actin filament depolymerization (GO:0030836)2.38320394
129microtubule depolymerization (GO:0007019)2.35882685
130protein K11-linked deubiquitination (GO:0035871)2.34516695
131DNA-dependent DNA replication (GO:0006261)2.34186944
132nucleotide-excision repair, DNA gap filling (GO:0006297)2.33234503
133regulation of nuclear cell cycle DNA replication (GO:0033262)2.32603266
134pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.30361536
135intraciliary transport (GO:0042073)2.29757361
136polyketide metabolic process (GO:0030638)2.28379981
137doxorubicin metabolic process (GO:0044598)2.28379981
138daunorubicin metabolic process (GO:0044597)2.28379981
139telomere maintenance (GO:0000723)2.27240233
140telomere maintenance via telomere lengthening (GO:0010833)2.26335513
141transcription-coupled nucleotide-excision repair (GO:0006283)2.26247216
142negative regulation of signal transduction by p53 class mediator (GO:1901797)2.26061316
143negative regulation of phagocytosis (GO:0050765)2.25237465
144negative regulation of myoblast differentiation (GO:0045662)2.24996228
145telomere organization (GO:0032200)2.24695774
146centriole replication (GO:0007099)2.24407197
147generation of neurons (GO:0048699)2.24233295
148histamine secretion (GO:0001821)2.22465723
149response to peptidoglycan (GO:0032494)2.22352066
150cellular response to gamma radiation (GO:0071480)2.21217587
151neutrophil activation (GO:0042119)2.21074910
152nuclear pore complex assembly (GO:0051292)2.20640724
153regulation of cell proliferation involved in kidney development (GO:1901722)2.20328268
154mitotic metaphase plate congression (GO:0007080)2.20265879
155facial nerve structural organization (GO:0021612)2.20103536
156negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.19022544
157positive regulation of DNA-dependent DNA replication (GO:2000105)2.18560013
158regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.17870545
159protein K6-linked ubiquitination (GO:0085020)2.16165356
160cullin deneddylation (GO:0010388)2.15771995
161deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.15636959
162negative regulation of DNA-dependent DNA replication (GO:2000104)2.14835381
163regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.14601869
164pore complex assembly (GO:0046931)2.14300693
165ventricular trabecula myocardium morphogenesis (GO:0003222)2.13953219
166myeloid dendritic cell activation (GO:0001773)2.12398475
167regulation of chemokine secretion (GO:0090196)2.11986891
168DNA damage response, detection of DNA damage (GO:0042769)2.11972774
169metaphase plate congression (GO:0051310)2.11913463
170deoxyribonucleotide biosynthetic process (GO:0009263)2.11864223
171protein neddylation (GO:0045116)2.10566714
172energy homeostasis (GO:0097009)2.10520891
173nuclear pore organization (GO:0006999)2.10160889
174dendritic cell migration (GO:0036336)2.08719893
175negative regulation of striated muscle cell apoptotic process (GO:0010664)2.07243268
176neural crest cell development (GO:0014032)2.07193519
177positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.06550219
178positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.06550219
179positive regulation of mitotic sister chromatid separation (GO:1901970)2.06550219
180transcription elongation from RNA polymerase II promoter (GO:0006368)2.06305847
181DNA synthesis involved in DNA repair (GO:0000731)2.05566873
182DNA double-strand break processing (GO:0000729)2.05498616
183DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.05403847
184maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.04656629

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.75747331
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.95543133
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.15221648
4AR_21909140_ChIP-Seq_LNCAP_Human3.07229273
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.05111262
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.98735249
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.86957636
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.86820074
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.85723321
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.61407889
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.61090340
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.60529438
13* ELK1_19687146_ChIP-ChIP_HELA_Human2.46076218
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.39058418
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.38681178
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.36116933
17MYCN_18555785_ChIP-Seq_MESCs_Mouse2.25604260
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.22711121
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.22184568
20ZFX_18555785_ChIP-Seq_MESCs_Mouse2.21685876
21* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.13958096
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.06860752
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.06548978
24PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.03957431
25IRF8_22096565_ChIP-ChIP_GC-B_Human2.01590514
26* XRN2_22483619_ChIP-Seq_HELA_Human1.95497001
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.91377698
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.91309404
29HOXB4_20404135_ChIP-ChIP_EML_Mouse1.86266594
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.84774211
31* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84447603
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84420191
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79541539
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79232407
35WT1_19549856_ChIP-ChIP_CCG9911_Human1.78189691
36ESR1_15608294_ChIP-ChIP_MCF-7_Human1.78100628
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76601935
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75501724
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73465960
40* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.72550225
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.70448567
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.69403704
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.69076940
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66373574
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64770472
46* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.62863928
47ZNF263_19887448_ChIP-Seq_K562_Human1.60675694
48* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.60164910
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59864451
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.58823854
51* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55765671
52EWS_26573619_Chip-Seq_HEK293_Human1.54559103
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54263531
54* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.54253441
55CLOCK_20551151_ChIP-Seq_293T_Human1.52218008
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51453875
57* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.51411367
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.51246248
59HIF1A_21447827_ChIP-Seq_MCF-7_Human1.50072721
60* VDR_23849224_ChIP-Seq_CD4+_Human1.47227345
61SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.46804069
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.46707427
63TFEB_21752829_ChIP-Seq_HELA_Human1.44256431
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43446711
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.43233850
66SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.41750149
67* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.39561172
68TP63_17297297_ChIP-ChIP_HaCaT_Human1.38206519
69* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37890821
70MYC_22102868_ChIP-Seq_BL_Human1.37080743
71IRF1_19129219_ChIP-ChIP_H3396_Human1.37044052
72* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.35711208
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35316740
74* MYC_18555785_ChIP-Seq_MESCs_Mouse1.35074154
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.34945533
76* GABP_19822575_ChIP-Seq_HepG2_Human1.34334084
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33780966
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.32713343
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.32245210
80FUS_26573619_Chip-Seq_HEK293_Human1.31971825
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.28581221
82* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28579018
83* KDM5A_27292631_Chip-Seq_BREAST_Human1.27883848
84CHD1_26751641_Chip-Seq_LNCaP_Human1.26275606
85CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.25940186
86EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.25930522
87NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25664114
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24906708
89HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24863662
90SOX17_20123909_ChIP-Seq_XEN_Mouse1.24607717
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.23751658
92STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22740670
93NFE2_27457419_Chip-Seq_LIVER_Mouse1.22511834
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22487644
95* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22063147
96ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21424686
97FOXP3_21729870_ChIP-Seq_TREG_Human1.21033538
98SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18517688
99SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.17475450
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.17175311
101ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15763775
102SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13328719
103ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12459047
104CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11927701
105SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11596143
106NANOG_21062744_ChIP-ChIP_HESCs_Human1.11139450
107STAT3_18555785_Chip-Seq_ESCs_Mouse1.10648011
108SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10483184
109TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10424336
110FOXM1_23109430_ChIP-Seq_U2OS_Human1.09978139
111E2F1_18555785_Chip-Seq_ESCs_Mouse1.07383267
112NMYC_18555785_Chip-Seq_ESCs_Mouse1.06659090
113* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06047054
114* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05745360
115PKCTHETA_26484144_Chip-Seq_BREAST_Human1.04866585
116BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04329183
117VDR_22108803_ChIP-Seq_LS180_Human1.04010871
118EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03153478
119TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02546740
120EZH2_27294783_Chip-Seq_NPCs_Mouse1.01423957
121SPI1_23547873_ChIP-Seq_NB4_Human1.00771291
122EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00745939
123P53_22387025_ChIP-Seq_ESCs_Mouse1.00604186
124HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00490401
125STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00038258
126KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99929618
127KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99929618
128KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99929618
129FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99909183
130DCP1A_22483619_ChIP-Seq_HELA_Human0.99415172
131STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99400464
132TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99273346
133* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98699294
134TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.98459614
135P300_18555785_Chip-Seq_ESCs_Mouse0.96170789
136* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95864948
137SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95062439
138TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94387408
139SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94073518
140SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94073518
141NANOG_16153702_ChIP-ChIP_HESCs_Human0.93999915
142RNF2_27304074_Chip-Seq_NSC_Mouse0.93943595
143* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93622384
144P300_19829295_ChIP-Seq_ESCs_Human0.93286939
145IRF8_27001747_Chip-Seq_BMDM_Mouse0.93148876
146CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92979045
147* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.92027712
148TTF2_22483619_ChIP-Seq_HELA_Human0.91547293
149CMYC_18555785_Chip-Seq_ESCs_Mouse0.91515388
150MYC_18940864_ChIP-ChIP_HL60_Human0.91108445
151IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.90452758
152NANOG_18555785_Chip-Seq_ESCs_Mouse0.90149765
153FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88771588
154ETS1_20019798_ChIP-Seq_JURKAT_Human0.87760517
155MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.87426532
156GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87161617
157ESR1_21235772_ChIP-Seq_MCF-7_Human0.87041266

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog2.70810576
2MP0010352_gastrointestinal_tract_polyps2.69937578
3MP0010234_abnormal_vibrissa_follicle2.67890474
4MP0000015_abnormal_ear_pigmentation2.65686588
5MP0008007_abnormal_cellular_replicative2.62702904
6MP0000566_synostosis2.62299821
7MP0008057_abnormal_DNA_replication2.48925062
8MP0010094_abnormal_chromosome_stability2.44140849
9MP0005076_abnormal_cell_differentiation2.40878554
10MP0008789_abnormal_olfactory_epithelium2.38112740
11MP0006292_abnormal_olfactory_placode2.25320914
12MP0001188_hyperpigmentation2.23824636
13MP0005171_absent_coat_pigmentation2.21185038
14MP0003941_abnormal_skin_development2.20961895
15MP0001730_embryonic_growth_arrest2.20274826
16MP0008058_abnormal_DNA_repair2.10681873
17MP0010307_abnormal_tumor_latency2.09279884
18MP0002132_abnormal_respiratory_system2.08556217
19MP0003890_abnormal_embryonic-extraembry2.03901019
20MP0001835_abnormal_antigen_presentation2.01513632
21MP0001672_abnormal_embryogenesis/_devel2.00568235
22MP0005380_embryogenesis_phenotype2.00568235
23MP0000350_abnormal_cell_proliferation2.00079592
24MP0000372_irregular_coat_pigmentation1.97557789
25MP0003984_embryonic_growth_retardation1.91252610
26MP0009672_abnormal_birth_weight1.88620072
27MP0002088_abnormal_embryonic_growth/wei1.86572112
28MP0000537_abnormal_urethra_morphology1.86281132
29MP0003787_abnormal_imprinting1.83095883
30MP0002148_abnormal_hypersensitivity_rea1.82451312
31MP0001697_abnormal_embryo_size1.81986818
32MP0010030_abnormal_orbit_morphology1.81360704
33MP0003221_abnormal_cardiomyocyte_apopto1.78603835
34MP0004233_abnormal_muscle_weight1.75295453
35MP0004782_abnormal_surfactant_physiolog1.72448448
36MP0002796_impaired_skin_barrier1.71885691
37MP0003136_yellow_coat_color1.69904417
38MP0003077_abnormal_cell_cycle1.69248268
39MP0005499_abnormal_olfactory_system1.66196485
40MP0005394_taste/olfaction_phenotype1.66196485
41MP0004264_abnormal_extraembryonic_tissu1.65257636
42MP0002086_abnormal_extraembryonic_tissu1.64946737
43MP0002080_prenatal_lethality1.64045560
44MP0005501_abnormal_skin_physiology1.62102031
45MP0005409_darkened_coat_color1.62100813
46MP0001346_abnormal_lacrimal_gland1.61096143
47MP0005367_renal/urinary_system_phenotyp1.60990645
48MP0000516_abnormal_urinary_system1.60990645
49MP0002938_white_spotting1.60922454
50MP0002084_abnormal_developmental_patter1.60639210
51MP0005408_hypopigmentation1.59124038
52MP0008877_abnormal_DNA_methylation1.58249676
53MP0002085_abnormal_embryonic_tissue1.54763968
54MP0003943_abnormal_hepatobiliary_system1.52259909
55MP0009785_altered_susceptibility_to1.51581114
56MP0002697_abnormal_eye_size1.48754540
57MP0003566_abnormal_cell_adhesion1.47974422
58MP0004197_abnormal_fetal_growth/weight/1.47964612
59MP0002396_abnormal_hematopoietic_system1.47292593
60MP0002877_abnormal_melanocyte_morpholog1.46606025
61MP0003786_premature_aging1.46208021
62MP0001727_abnormal_embryo_implantation1.45794795
63MP0003121_genomic_imprinting1.39159521
64MP0002163_abnormal_gland_morphology1.38289813
65MP0002095_abnormal_skin_pigmentation1.36940996
66MP0010678_abnormal_skin_adnexa1.36680603
67MP0003111_abnormal_nucleus_morphology1.34623161
68MP0002092_abnormal_eye_morphology1.33508009
69MP0005174_abnormal_tail_pigmentation1.33448597
70MP0001879_abnormal_lymphatic_vessel1.33330238
71MP0002009_preneoplasia1.33088727
72MP0003315_abnormal_perineum_morphology1.31811717
73MP0001849_ear_inflammation1.31136004
74MP0003763_abnormal_thymus_physiology1.29705054
75MP0005671_abnormal_response_to1.27852745
76MP0002751_abnormal_autonomic_nervous1.24462682
77MP0000490_abnormal_crypts_of1.23750885
78MP0009697_abnormal_copulation1.23466590
79MP0009703_decreased_birth_body1.23189479
80MP0003693_abnormal_embryo_hatching1.21941925
81MP0000049_abnormal_middle_ear1.21727866
82MP0001915_intracranial_hemorrhage1.21438209
83MP0004134_abnormal_chest_morphology1.21329021
84MP0008932_abnormal_embryonic_tissue1.21275571
85MP0004185_abnormal_adipocyte_glucose1.19924008
86MP0002277_abnormal_respiratory_mucosa1.19168125
87MP0005451_abnormal_body_composition1.17702053
88MP0000313_abnormal_cell_death1.17168316
89MP0005075_abnormal_melanosome_morpholog1.14579290
90MP0004808_abnormal_hematopoietic_stem1.14269260
91MP0009053_abnormal_anal_canal1.13773875
92MP0000627_abnormal_mammary_gland1.12428887
93MP0004147_increased_porphyrin_level1.09661390
94MP0002177_abnormal_outer_ear1.09564340
95MP0009250_abnormal_appendicular_skeleto1.09241934
96MP0005248_abnormal_Harderian_gland1.07839070
97MP0003453_abnormal_keratinocyte_physiol1.06950972
98MP0005621_abnormal_cell_physiology1.06882038
99MP0002419_abnormal_innate_immunity1.05415747
100MP0003937_abnormal_limbs/digits/tail_de1.04396520
101MP0003385_abnormal_body_wall1.03286964
102MP0002160_abnormal_reproductive_system1.03175896
103MP0003828_pulmonary_edema1.02250238
104MP0005384_cellular_phenotype1.01053013
105MP0000358_abnormal_cell_content/1.00927996
106MP0002233_abnormal_nose_morphology1.00676749
107MP0004272_abnormal_basement_membrane1.00598730
108MP0000377_abnormal_hair_follicle1.00255156
109MP0002452_abnormal_antigen_presenting0.99377415
110MP0001216_abnormal_epidermal_layer0.99046622
111MP0004381_abnormal_hair_follicle0.96945703
112MP0000569_abnormal_digit_pigmentation0.96705112
113MP0009333_abnormal_splenocyte_physiolog0.95580852
114MP0002249_abnormal_larynx_morphology0.95138658
115MP0000383_abnormal_hair_follicle0.95026907
116MP0003186_abnormal_redox_activity0.93853236
117MP0005257_abnormal_intraocular_pressure0.92488989
118MP0002420_abnormal_adaptive_immunity0.92236415
119MP0009379_abnormal_foot_pigmentation0.91282295
120MP0001819_abnormal_immune_cell0.91067906
121MP0001186_pigmentation_phenotype0.90915975
122MP0005000_abnormal_immune_tolerance0.89943196
123MP0001986_abnormal_taste_sensitivity0.89829285
124MP0008260_abnormal_autophagy0.89167300
125MP0001119_abnormal_female_reproductive0.88783722
126MP0003755_abnormal_palate_morphology0.87644508
127MP0002111_abnormal_tail_morphology0.87032027
128MP0001286_abnormal_eye_development0.86320686
129MP0002019_abnormal_tumor_incidence0.85363499
130MP0005389_reproductive_system_phenotype0.85098912
131MP0005025_abnormal_response_to0.84526114
132MP0000428_abnormal_craniofacial_morphol0.83868175
133MP0003115_abnormal_respiratory_system0.83586472
134MP0002060_abnormal_skin_morphology0.83485954
135MP0001881_abnormal_mammary_gland0.83231195
136MP0000681_abnormal_thyroid_gland0.82576722
137MP0002398_abnormal_bone_marrow0.82397328
138MP0006054_spinal_hemorrhage0.82174704
139MP0001293_anophthalmia0.81691354
140MP0003724_increased_susceptibility_to0.81582700
141MP0005503_abnormal_tendon_morphology0.81558981
142MP0004957_abnormal_blastocyst_morpholog0.80519151
143MP0003567_abnormal_fetal_cardiomyocyte0.80219270
144MP0002405_respiratory_system_inflammati0.80213279
145MP0003935_abnormal_craniofacial_develop0.80185105
146MP0000678_abnormal_parathyroid_gland0.79324453
147MP0003091_abnormal_cell_migration0.78790666
148MP0002723_abnormal_immune_serum0.78315263
149MP0002098_abnormal_vibrissa_morphology0.77967503
150MP0003436_decreased_susceptibility_to0.76628145
151MP0001919_abnormal_reproductive_system0.76592166
152MP0001800_abnormal_humoral_immune0.75359798
153MP0005197_abnormal_uvea_morphology0.74509386
154MP0001177_atelectasis0.74444260
155MP0001790_abnormal_immune_system0.74197754
156MP0005387_immune_system_phenotype0.74197754
157MP0003942_abnormal_urinary_system0.74168159
158MP0005623_abnormal_meninges_morphology0.72455298
159MP0002006_tumorigenesis0.72020261
160MP0003718_maternal_effect0.71399541
161MP0001340_abnormal_eyelid_morphology0.70749627
162MP0003123_paternal_imprinting0.70449808
163MP0000647_abnormal_sebaceous_gland0.69546767
164MP0002166_altered_tumor_susceptibility0.69098112
165MP0000462_abnormal_digestive_system0.68439214
166MP0000579_abnormal_nail_morphology0.65971714
167MP0001529_abnormal_vocalization0.64440635

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)3.88024048
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.74574152
3Microglossia (HP:0000171)3.74430393
4Chromsome breakage (HP:0040012)3.68878438
5Abnormal lung lobation (HP:0002101)3.23504659
6Termporal pattern (HP:0011008)3.13299946
7Insidious onset (HP:0003587)3.13299946
8Increased nuchal translucency (HP:0010880)2.96687672
9Type I transferrin isoform profile (HP:0003642)2.91218045
10Absent frontal sinuses (HP:0002688)2.87604839
11Overlapping toe (HP:0001845)2.69727472
12True hermaphroditism (HP:0010459)2.69329427
13Alveolar cell carcinoma (HP:0006519)2.66612048
14Ectopic kidney (HP:0000086)2.63962912
15Abnormality of incisor morphology (HP:0011063)2.60038877
16Multiple enchondromatosis (HP:0005701)2.58142219
17Deviation of the thumb (HP:0009603)2.56947127
18Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.56145996
19Nephroblastoma (Wilms tumor) (HP:0002667)2.54967846
20Stomach cancer (HP:0012126)2.53777525
21Embryonal renal neoplasm (HP:0011794)2.51681892
22Prostate neoplasm (HP:0100787)2.47935279
23Breast carcinoma (HP:0003002)2.47058240
24Proximal placement of thumb (HP:0009623)2.46507419
25Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.45507105
26Spastic diplegia (HP:0001264)2.45024478
27Septate vagina (HP:0001153)2.44440966
28Abnormality of the renal collecting system (HP:0004742)2.44230481
29Abnormality of the nasal septum (HP:0000419)2.40178208
30Micronodular cirrhosis (HP:0001413)2.39996573
31Capillary hemangiomas (HP:0005306)2.38742203
32Hyperacusis (HP:0010780)2.38358499
33White forelock (HP:0002211)2.36718334
34Pulmonary artery stenosis (HP:0004415)2.31823366
35Medulloblastoma (HP:0002885)2.31750509
36Patchy hypopigmentation of hair (HP:0011365)2.31060891
37Neoplasm of the tracheobronchial system (HP:0100552)2.30952702
38* Deep philtrum (HP:0002002)2.29980636
39Optic neuritis (HP:0100653)2.28808964
40Retrobulbar optic neuritis (HP:0100654)2.28808964
4111 pairs of ribs (HP:0000878)2.28125735
42Recurrent abscess formation (HP:0002722)2.26120029
43Adrenal hypoplasia (HP:0000835)2.26048656
44Abnormality of the carotid arteries (HP:0005344)2.25763932
45Optic nerve coloboma (HP:0000588)2.25320487
46Absent eyebrow (HP:0002223)2.24348780
47Meckel diverticulum (HP:0002245)2.23807305
48Progressive external ophthalmoplegia (HP:0000590)2.20705156
49Abnormality of the umbilical cord (HP:0010881)2.20698680
50Hypothermia (HP:0002045)2.18387172
51J-shaped sella turcica (HP:0002680)2.17468159
52Cafe-au-lait spot (HP:0000957)2.16792805
53Abnormality of the ileum (HP:0001549)2.15134594
54Duplicated collecting system (HP:0000081)2.13511405
55Missing ribs (HP:0000921)2.13333284
56Patellar aplasia (HP:0006443)2.13048483
57Abnormal hair whorl (HP:0010721)2.11280813
58Aplasia/hypoplasia of the humerus (HP:0006507)2.11202733
59Preaxial hand polydactyly (HP:0001177)2.08501564
60Abnormality of the preputium (HP:0100587)2.07400833
61Lip pit (HP:0100267)2.05622714
62Selective tooth agenesis (HP:0001592)2.04982964
63Arteriovenous malformation (HP:0100026)2.04389419
64Aplasia/Hypoplasia of the patella (HP:0006498)2.02970224
65Abnormality of chromosome stability (HP:0003220)2.01952219
66Abnormality of the fetal cardiovascular system (HP:0010948)2.00747297
67Abnormal umbilical cord blood vessels (HP:0011403)2.00747297
68Single umbilical artery (HP:0001195)2.00747297
69Rhabdomyosarcoma (HP:0002859)1.99096196
70Pancreatic fibrosis (HP:0100732)1.98614442
71Ankyloglossia (HP:0010296)1.98117534
72Progressive muscle weakness (HP:0003323)1.97144539
73Short humerus (HP:0005792)1.96256022
74* Asymmetry of the thorax (HP:0001555)1.95453983
75Orthostatic hypotension (HP:0001278)1.94860533
76Birth length less than 3rd percentile (HP:0003561)1.93953397
77Hypopigmentation of the fundus (HP:0007894)1.93556970
78Embryonal neoplasm (HP:0002898)1.92803674
79Overriding aorta (HP:0002623)1.92398019
80Septo-optic dysplasia (HP:0100842)1.91755860
81Aplasia/Hypoplasia of the uvula (HP:0010293)1.89978656
82* Leiomyosarcoma (HP:0100243)1.89862504
83* Uterine leiomyosarcoma (HP:0002891)1.89862504
84Increased IgM level (HP:0003496)1.89276106
85Abnormality of the prostate (HP:0008775)1.86633809
86Abnormality of the anterior horn cell (HP:0006802)1.86372178
87Degeneration of anterior horn cells (HP:0002398)1.86372178
88* Thyroid carcinoma (HP:0002890)1.86328857
89Insomnia (HP:0100785)1.85938003
90Recurrent pneumonia (HP:0006532)1.85586386
91Microvesicular hepatic steatosis (HP:0001414)1.85574363
92Renal duplication (HP:0000075)1.85529533
93Esophageal varix (HP:0002040)1.85079845
94Abnormality of oral frenula (HP:0000190)1.84852774
95High anterior hairline (HP:0009890)1.84606454
96* Malignant gastrointestinal tract tumors (HP:0006749)1.84195608
97* Gastrointestinal carcinoma (HP:0002672)1.84195608
98Small intestinal stenosis (HP:0012848)1.84098980
99Duodenal stenosis (HP:0100867)1.84098980
100Abnormal foot bone ossification (HP:0010675)1.83145184
101Abnormalities of placenta or umbilical cord (HP:0001194)1.83046740
102Acute myeloid leukemia (HP:0004808)1.82796816
103Clubbing of toes (HP:0100760)1.82169062
104Orchitis (HP:0100796)1.81804855
105Skull defect (HP:0001362)1.81669847
106Osteolytic defects of the hand bones (HP:0009699)1.81022798
107Osteolytic defects of the phalanges of the hand (HP:0009771)1.81022798
108Abnormality of the lacrimal duct (HP:0011481)1.80554924
109Cupped ear (HP:0000378)1.80460197
110Long palpebral fissure (HP:0000637)1.79535607
111Eczematoid dermatitis (HP:0000976)1.79470550
112* Transitional cell carcinoma of the bladder (HP:0006740)1.79091731
113Myelodysplasia (HP:0002863)1.78642628
114Type 2 muscle fiber atrophy (HP:0003554)1.78520356
115Shoulder girdle muscle weakness (HP:0003547)1.78258649
116Prolonged neonatal jaundice (HP:0006579)1.78132603
117Myelomeningocele (HP:0002475)1.78020085
118Intestinal atresia (HP:0011100)1.77466107
119Pancreatic cysts (HP:0001737)1.77143259
120Back pain (HP:0003418)1.76947874
121Abnormality of hair growth rate (HP:0011363)1.76189369
122Slow-growing hair (HP:0002217)1.76189369
123Eosinophilia (HP:0001880)1.76156171
124Reduced antithrombin III activity (HP:0001976)1.75926690
125Abnormality of the columella (HP:0009929)1.75086386
126Keratoconjunctivitis sicca (HP:0001097)1.74715980
127Abnormality of the intervertebral disk (HP:0005108)1.74651657
128Abnormality of the incisor (HP:0000676)1.74638958
129Abnormality of the nasolacrimal system (HP:0000614)1.74135771
130Neoplasm of the pancreas (HP:0002894)1.73852918
131Metaphyseal dysplasia (HP:0100255)1.73847295
132Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.73210521
133Optic nerve hypoplasia (HP:0000609)1.72915775
134Postaxial foot polydactyly (HP:0001830)1.72164456
135Bone marrow hypocellularity (HP:0005528)1.70722882
136Recurrent bacterial skin infections (HP:0005406)1.70530681
137Choanal atresia (HP:0000453)1.70192409
138Elfin facies (HP:0004428)1.69922048
139* Uterine neoplasm (HP:0010784)1.69797034
140* Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.69763044
141Mediastinal lymphadenopathy (HP:0100721)1.69335662
142Chronic obstructive pulmonary disease (HP:0006510)1.68425123
143Obstructive lung disease (HP:0006536)1.68425123
144Abnormality of midbrain morphology (HP:0002418)1.67362926
145Molar tooth sign on MRI (HP:0002419)1.67362926
146* Bladder carcinoma (HP:0002862)1.67154318
147* Bladder neoplasm (HP:0009725)1.67154318
148Flat acetabular roof (HP:0003180)1.67147404
149Abnormal protein glycosylation (HP:0012346)1.66084053
150Abnormal glycosylation (HP:0012345)1.66084053
151Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.66084053
152Abnormal protein N-linked glycosylation (HP:0012347)1.66084053
153Xerostomia (HP:0000217)1.66058014
154Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.65999043
155Acute lymphatic leukemia (HP:0006721)1.65615591
156Glomerulopathy (HP:0100820)1.65484500
157Renal hypoplasia (HP:0000089)1.65185517
158Mesomelia (HP:0003027)1.64516200
159Abnormality of the frontal sinuses (HP:0002687)1.64331307
160Subacute progressive viral hepatitis (HP:0006572)1.63936132
161Pelvic girdle muscle weakness (HP:0003749)1.63332602
162Abnormality of the septum pellucidum (HP:0007375)1.62801538
163Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.62156074
164Papillary thyroid carcinoma (HP:0002895)1.62070118
165Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.62007717
166Osteomalacia (HP:0002749)1.61942269
167Medial flaring of the eyebrow (HP:0010747)1.61710616
168Heterochromia iridis (HP:0001100)1.61536631
169Facial hemangioma (HP:0000329)1.61318206
170Myositis (HP:0100614)1.61264228
171Abnormality of glycolysis (HP:0004366)1.61202479
172Granulocytopenia (HP:0001913)1.60952409
173Keratoconjunctivitis (HP:0001096)1.59776386
174Tetraparesis (HP:0002273)1.58046833
175Aplasia/Hypoplasia of the sacrum (HP:0008517)1.57777529
176Progressive hearing impairment (HP:0001730)1.57500009
177Breech presentation (HP:0001623)1.57412977
178Renal cortical cysts (HP:0000803)1.56981093
179Arnold-Chiari malformation (HP:0002308)1.56459746
180Premature graying of hair (HP:0002216)1.55326744
181Aplasia/Hypoplasia of the fovea (HP:0008060)1.55174632
182Hypoplasia of the fovea (HP:0007750)1.55174632
183Absent radius (HP:0003974)1.54053395

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SCYL23.98835620
2ERBB33.51306112
3MKNK13.17415632
4PRPF4B3.12059024
5BMPR23.00603667
6ZAK2.84894170
7MAP3K142.75264273
8SRPK12.58291255
9NEK12.37535864
10MKNK22.34635872
11CASK2.33253091
12IRAK42.33235079
13PLK42.24289394
14MAP3K102.24147445
15RPS6KB22.12083409
16BMPR1B2.01934147
17TRIM282.01803684
18SIK32.00030788
19TRIB31.98826477
20PKN21.98306863
21TAF11.95187892
22CLK11.91822301
23TXK1.88751034
24BCR1.86365180
25YES11.82041825
26NUAK11.80062169
27AKT31.74852359
28PAK41.71697321
29EEF2K1.68735743
30NEK91.66236099
31NEK61.61067729
32WEE11.59490795
33SMG11.59237179
34EIF2AK21.55761830
35MST41.55037420
36NME21.53931544
37VRK11.53566577
38PBK1.49628693
39CDK61.44455992
40CDK121.43995853
41PLK31.43022525
42STK241.41657553
43IRAK31.40597917
44RPS6KA41.34076312
45LATS21.33009164
46TRPM71.32702783
47PLK21.32335689
48STK38L1.25059990
49BRSK21.24208243
50MAP3K121.21883505
51SGK21.19495441
52IKBKB1.18514669
53CDK81.17358274
54PIM21.15671297
55EIF2AK31.15409789
56PDGFRA1.15260371
57KSR11.12723139
58VRK21.10404539
59PIK3CA1.09194923
60TGFBR11.07461558
61EIF2AK11.07139368
62CHUK1.04815883
63TNIK1.03776346
64STK161.01535631
65FGFR41.01112866
66ERBB40.96400654
67LATS10.94643781
68STK40.89782025
69BUB10.88990578
70NLK0.88562650
71TEC0.87435477
72ALK0.86635589
73CDC70.86395963
74MAPK130.85167252
75SIK10.84612360
76ATR0.84430676
77JAK30.82548431
78ICK0.79361790
79BRD40.78972698
80STK30.78540372
81PIM10.78031150
82DYRK20.78022391
83IKBKE0.77478313
84TSSK60.77299568
85ADRBK20.77034394
86NEK20.76945938
87MAP3K80.75335411
88OBSCN0.74135903
89TESK10.71724146
90LIMK10.71036120
91CCNB10.70844097
92PASK0.66926426
93DYRK30.66925868
94SGK2230.62958310
95SGK4940.62958310
96CDK30.62567239
97BRSK10.62433912
98FGFR10.61807798
99TIE10.61467593
100ILK0.61362761
101MAP3K90.61338027
102PLK10.61072130
103MUSK0.60748428
104STK100.60397588
105CDK40.60264033
106IRAK10.60048637
107CHEK20.57626535
108RPS6KL10.57077710
109RPS6KC10.57077710
110KSR20.56739180
111RPS6KA60.55797042
112MAP3K30.54794870
113MTOR0.54549915
114RPS6KB10.54543297
115AURKA0.54500131
116ACVR1B0.54292595
117CDK180.53650729
118MELK0.53015239
119MAPKAPK20.52406596
120AURKB0.51712110
121CDK70.51592854
122PAK20.51397485
123TAOK20.50826938
124RPS6KA50.50547346
125EPHA30.49695638
126MAP2K70.49057575
127GRK70.49037581
128AKT20.47745160
129CDK140.47676098
130SGK30.47205689
131EPHB20.46831628
132ATM0.46458701
133CDK10.45069182
134BTK0.45015631
135CDK90.44195657
136KIT0.44156723
137CSNK2A10.43894966
138CDK150.43322819
139CDK20.42463140
140TESK20.40649155
141BRAF0.40595342
142TTK0.40442291
143MYLK0.39981319
144TGFBR20.38478413
145CDK11A0.37467759
146IRAK20.35686152
147MAPKAPK50.34080595
148EPHA20.32573114
149LYN0.32509937
150RET0.30296333
151PTK60.30220587
152CHEK10.30140654

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.82565519
2Homologous recombination_Homo sapiens_hsa034402.60268614
3Base excision repair_Homo sapiens_hsa034102.46204735
4Mismatch repair_Homo sapiens_hsa034302.45183881
5Proteasome_Homo sapiens_hsa030502.37576960
6Non-homologous end-joining_Homo sapiens_hsa034502.24754018
7Basal transcription factors_Homo sapiens_hsa030222.16165359
8RNA polymerase_Homo sapiens_hsa030202.11319742
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.08353718
10Fanconi anemia pathway_Homo sapiens_hsa034601.98376684
11* Thyroid cancer_Homo sapiens_hsa052161.92548378
12Nucleotide excision repair_Homo sapiens_hsa034201.92444094
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.86417031
14Spliceosome_Homo sapiens_hsa030401.81719944
15Cell cycle_Homo sapiens_hsa041101.81690503
16Allograft rejection_Homo sapiens_hsa053301.80558978
17Graft-versus-host disease_Homo sapiens_hsa053321.78267715
18Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.76096802
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.75032058
20RNA degradation_Homo sapiens_hsa030181.66509598
21Protein export_Homo sapiens_hsa030601.58558434
22Biosynthesis of amino acids_Homo sapiens_hsa012301.57415671
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.50296974
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.50041716
25Autoimmune thyroid disease_Homo sapiens_hsa053201.46839773
26* Chronic myeloid leukemia_Homo sapiens_hsa052201.42713738
27* Central carbon metabolism in cancer_Homo sapiens_hsa052301.38108482
28Measles_Homo sapiens_hsa051621.37974547
29RNA transport_Homo sapiens_hsa030131.37667009
30Leishmaniasis_Homo sapiens_hsa051401.35030575
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.34593437
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.34155889
33Pyrimidine metabolism_Homo sapiens_hsa002401.33627475
34Herpes simplex infection_Homo sapiens_hsa051681.33098009
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.33044035
36Arachidonic acid metabolism_Homo sapiens_hsa005901.32629681
37Pancreatic cancer_Homo sapiens_hsa052121.32404047
38Pentose phosphate pathway_Homo sapiens_hsa000301.31914782
39Colorectal cancer_Homo sapiens_hsa052101.27555897
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26826395
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26316803
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25407959
43mRNA surveillance pathway_Homo sapiens_hsa030151.19850554
44Legionellosis_Homo sapiens_hsa051341.18934784
45Steroid biosynthesis_Homo sapiens_hsa001001.17988020
46Asthma_Homo sapiens_hsa053101.17586419
47* Endometrial cancer_Homo sapiens_hsa052131.15409332
48p53 signaling pathway_Homo sapiens_hsa041151.12965528
49N-Glycan biosynthesis_Homo sapiens_hsa005101.12238699
50Toll-like receptor signaling pathway_Homo sapiens_hsa046201.12076465
51Selenocompound metabolism_Homo sapiens_hsa004501.11547139
52* Bladder cancer_Homo sapiens_hsa052191.11514086
53Epstein-Barr virus infection_Homo sapiens_hsa051691.11426243
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.08658127
55One carbon pool by folate_Homo sapiens_hsa006701.06663032
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06081681
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.04849517
58* Renal cell carcinoma_Homo sapiens_hsa052111.04742650
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04677945
60Influenza A_Homo sapiens_hsa051641.03035967
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02890157
62Carbon metabolism_Homo sapiens_hsa012001.02513377
63Malaria_Homo sapiens_hsa051441.00095992
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99651539
65Shigellosis_Homo sapiens_hsa051310.97932894
66Viral myocarditis_Homo sapiens_hsa054160.96514693
67Hematopoietic cell lineage_Homo sapiens_hsa046400.96346951
68Pertussis_Homo sapiens_hsa051330.93190101
69* Non-small cell lung cancer_Homo sapiens_hsa052230.92265871
70Rheumatoid arthritis_Homo sapiens_hsa053230.90217562
71Purine metabolism_Homo sapiens_hsa002300.89003511
72Ribosome_Homo sapiens_hsa030100.87743957
73* Proteoglycans in cancer_Homo sapiens_hsa052050.85671919
74Primary immunodeficiency_Homo sapiens_hsa053400.85117985
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84444478
76Salmonella infection_Homo sapiens_hsa051320.84144238
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.83989414
78mTOR signaling pathway_Homo sapiens_hsa041500.83139270
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82535345
80Ether lipid metabolism_Homo sapiens_hsa005650.77836468
81* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77681716
82HIF-1 signaling pathway_Homo sapiens_hsa040660.76199198
83Phagosome_Homo sapiens_hsa041450.75721155
84* HTLV-I infection_Homo sapiens_hsa051660.74454529
85Oocyte meiosis_Homo sapiens_hsa041140.74159609
86TGF-beta signaling pathway_Homo sapiens_hsa043500.72911767
87TNF signaling pathway_Homo sapiens_hsa046680.72760155
88Toxoplasmosis_Homo sapiens_hsa051450.72407595
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71738448
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69325331
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67883346
92Antigen processing and presentation_Homo sapiens_hsa046120.67090919
93Galactose metabolism_Homo sapiens_hsa000520.66540979
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66350969
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63867356
96* MicroRNAs in cancer_Homo sapiens_hsa052060.63412869
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63199604
98Basal cell carcinoma_Homo sapiens_hsa052170.61794992
99* Hepatitis B_Homo sapiens_hsa051610.60282019
100* Apoptosis_Homo sapiens_hsa042100.59883380
101Hippo signaling pathway_Homo sapiens_hsa043900.59595089
102* ErbB signaling pathway_Homo sapiens_hsa040120.59520493
103* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59504842
104Adherens junction_Homo sapiens_hsa045200.59393531
105Sphingolipid metabolism_Homo sapiens_hsa006000.58346438
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58141123
107Fatty acid elongation_Homo sapiens_hsa000620.57956769
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57596058
109* Acute myeloid leukemia_Homo sapiens_hsa052210.57313462
110* Viral carcinogenesis_Homo sapiens_hsa052030.56407847
111* Alcoholism_Homo sapiens_hsa050340.56188628
112Lysine degradation_Homo sapiens_hsa003100.55372744
113* Glioma_Homo sapiens_hsa052140.55048227
114Type I diabetes mellitus_Homo sapiens_hsa049400.54608652
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53805258
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.53397450
117Pyruvate metabolism_Homo sapiens_hsa006200.52304778
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52234720
119Fructose and mannose metabolism_Homo sapiens_hsa000510.51154678
120Vibrio cholerae infection_Homo sapiens_hsa051100.51130874
121Vitamin B6 metabolism_Homo sapiens_hsa007500.50989915
122* Neurotrophin signaling pathway_Homo sapiens_hsa047220.50148875
123Tuberculosis_Homo sapiens_hsa051520.50120556
124* Melanoma_Homo sapiens_hsa052180.49970500
125Phototransduction_Homo sapiens_hsa047440.49930249
126Small cell lung cancer_Homo sapiens_hsa052220.49519539
127* Hepatitis C_Homo sapiens_hsa051600.49001072
128Osteoclast differentiation_Homo sapiens_hsa043800.48996155
129* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48879774
130Glutathione metabolism_Homo sapiens_hsa004800.48548675
131African trypanosomiasis_Homo sapiens_hsa051430.48425725
132Systemic lupus erythematosus_Homo sapiens_hsa053220.48371531
133* Prostate cancer_Homo sapiens_hsa052150.46154390
134* Pathways in cancer_Homo sapiens_hsa052000.44893969
135AMPK signaling pathway_Homo sapiens_hsa041520.44629119
136Linoleic acid metabolism_Homo sapiens_hsa005910.44078489
137Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43539799
138* Insulin signaling pathway_Homo sapiens_hsa049100.42914738
139* Tight junction_Homo sapiens_hsa045300.41516536
140* Prolactin signaling pathway_Homo sapiens_hsa049170.40462667
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40006872
142Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39915464
143* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39724524
144* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39202866
145* Chemokine signaling pathway_Homo sapiens_hsa040620.38048851
146Huntingtons disease_Homo sapiens_hsa050160.37999263
147* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37599957
148alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36429103
149Wnt signaling pathway_Homo sapiens_hsa043100.36383804
150Notch signaling pathway_Homo sapiens_hsa043300.36264069

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »