NRBF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.58630524
2positive regulation by organism of defense response of other organism involved in symbiotic interact5.58630524
3modulation by symbiont of host immune response (GO:0052553)5.58630524
4positive regulation by symbiont of host defense response (GO:0052509)5.58630524
5modulation by symbiont of host defense response (GO:0052031)5.58630524
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.58630524
7neutrophil activation involved in immune response (GO:0002283)5.08319893
8detection of molecule of bacterial origin (GO:0032490)4.96428011
9positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.83989677
10negative regulation of cell killing (GO:0031342)4.62846383
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.62846383
12DNA deamination (GO:0045006)4.60351241
13macrophage activation involved in immune response (GO:0002281)4.51739989
14positive regulation of gamma-delta T cell activation (GO:0046645)4.39103913
15negative regulation of interleukin-12 production (GO:0032695)4.34679664
16regulation of interferon-beta biosynthetic process (GO:0045357)4.34474074
17detection of other organism (GO:0098543)4.28886379
18regulation of nitric-oxide synthase biosynthetic process (GO:0051769)4.23041452
19neutrophil activation (GO:0042119)4.17970109
20detection of external biotic stimulus (GO:0098581)4.15694027
21response to peptidoglycan (GO:0032494)4.11589261
22cellular extravasation (GO:0045123)4.11264253
23positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.05969038
24regulation of B cell receptor signaling pathway (GO:0050855)3.92798679
25granulocyte activation (GO:0036230)3.87517773
26detection of bacterium (GO:0016045)3.80151616
27neutrophil mediated immunity (GO:0002446)3.79574856
28respiratory burst (GO:0045730)3.79185827
29response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.74789783
30response to host immune response (GO:0052572)3.74789783
31detection of biotic stimulus (GO:0009595)3.72691806
32microglial cell activation (GO:0001774)3.71904808
33production of molecular mediator involved in inflammatory response (GO:0002532)3.68095750
34myeloid leukocyte mediated immunity (GO:0002444)3.46710590
35macrophage activation (GO:0042116)3.46393990
36myeloid cell activation involved in immune response (GO:0002275)3.45682987
37leukocyte migration involved in inflammatory response (GO:0002523)3.40920310
38cysteine metabolic process (GO:0006534)3.38514125
39L-phenylalanine metabolic process (GO:0006558)3.35137264
40erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.35137264
41response to interleukin-15 (GO:0070672)3.34321173
42leukocyte aggregation (GO:0070486)3.32552355
43positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.31420109
44response to host (GO:0075136)3.31339858
45response to host defenses (GO:0052200)3.31339858
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.31339858
47cellular response to interleukin-15 (GO:0071350)3.24835408
48proteasome assembly (GO:0043248)3.24626762
49type I interferon signaling pathway (GO:0060337)3.21694423
50cellular response to type I interferon (GO:0071357)3.21694423
51response to type I interferon (GO:0034340)3.11418322
52positive regulation of toll-like receptor signaling pathway (GO:0034123)3.11270283
53positive regulation of interleukin-8 secretion (GO:2000484)3.11014014
54folic acid-containing compound biosynthetic process (GO:0009396)3.09794551
55positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.09566198
56valine metabolic process (GO:0006573)3.09442607
57negative regulation of lymphocyte mediated immunity (GO:0002707)3.08304459
58erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.07897851
59L-phenylalanine catabolic process (GO:0006559)3.07897851
60nucleoside salvage (GO:0043174)3.07868408
61regulation of T cell tolerance induction (GO:0002664)3.07090286
62formation of translation preinitiation complex (GO:0001731)3.06113518
63dendritic cell migration (GO:0036336)3.04003103
64leukocyte degranulation (GO:0043299)3.00389422
65positive regulation of interferon-alpha production (GO:0032727)2.98616743
66antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.96671090
67antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.95040869
68antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.93361392
69antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.93361392
70negative regulation of T cell mediated immunity (GO:0002710)2.93089532
71folic acid metabolic process (GO:0046655)2.92617861
72triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.90067920
73activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.89512964
74Arp2/3 complex-mediated actin nucleation (GO:0034314)2.88538781
75lipopolysaccharide-mediated signaling pathway (GO:0031663)2.86843448
76L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.86760707
77regulation of interleukin-8 biosynthetic process (GO:0045414)2.86280577
78regulation of gamma-delta T cell activation (GO:0046643)2.85818174
79negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.84627959
80amino acid salvage (GO:0043102)2.84594004
81L-methionine salvage (GO:0071267)2.84594004
82L-methionine biosynthetic process (GO:0071265)2.84594004
83regulation of interferon-alpha production (GO:0032647)2.84006103
84aldehyde catabolic process (GO:0046185)2.82649740
85positive regulation of interferon-beta production (GO:0032728)2.81922748
86regulation of tolerance induction (GO:0002643)2.80881951
87pteridine-containing compound biosynthetic process (GO:0042559)2.80588467
88regulation of B cell differentiation (GO:0045577)2.73622419
89myeloid leukocyte activation (GO:0002274)2.73525953
90positive regulation of B cell differentiation (GO:0045579)2.72579479
91negative regulation of interleukin-1 production (GO:0032692)2.72428440
92signal peptide processing (GO:0006465)2.71492567
93regulation of alpha-beta T cell proliferation (GO:0046640)2.70602000
94regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.69693288
95regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.68816519
96negative regulation of leukocyte mediated immunity (GO:0002704)2.68675248
97sulfur amino acid biosynthetic process (GO:0000097)2.68533373
98dendritic cell chemotaxis (GO:0002407)2.67876679
99regulation of cellular amino acid metabolic process (GO:0006521)2.67129764
100immunoglobulin mediated immune response (GO:0016064)2.66838050
101response to interferon-alpha (GO:0035455)2.66650131
102negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.65686552
103regulation of mast cell degranulation (GO:0043304)2.65254474
104deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.63900084
105phagosome maturation (GO:0090382)2.63883976
106interferon-gamma-mediated signaling pathway (GO:0060333)2.63871893
107purine-containing compound salvage (GO:0043101)2.61911617
108pentose-phosphate shunt (GO:0006098)2.61878301
109cellular metabolic compound salvage (GO:0043094)2.61814775
110positive regulation of NF-kappaB import into nucleus (GO:0042346)2.61074537
111positive regulation of protein homooligomerization (GO:0032464)2.60856920
112antigen processing and presentation of endogenous antigen (GO:0019883)2.60628885
113aromatic amino acid family catabolic process (GO:0009074)2.59306931
114positive regulation of interleukin-1 beta secretion (GO:0050718)2.58281756
115lysine metabolic process (GO:0006553)2.58157935
116lysine catabolic process (GO:0006554)2.58157935
117pyrimidine nucleoside salvage (GO:0043097)2.57821208
118pyrimidine-containing compound salvage (GO:0008655)2.57821208
119regulation of interleukin-17 production (GO:0032660)2.56327304
120cytokine secretion (GO:0050663)2.55758213
121defense response to protozoan (GO:0042832)2.55727262
122negative regulation of interleukin-1 beta production (GO:0032691)2.55396975
123positive regulation of interleukin-8 production (GO:0032757)2.54410112
124cellular defense response (GO:0006968)2.54285510
125positive regulation of mast cell activation (GO:0033005)2.52061016
126I-kappaB phosphorylation (GO:0007252)2.51840453
127rRNA modification (GO:0000154)2.51783098
128one-carbon metabolic process (GO:0006730)2.51747025
129glycine metabolic process (GO:0006544)2.51473674
130negative regulation of interleukin-17 production (GO:0032700)2.51256302
131regulation of T cell mediated cytotoxicity (GO:0001914)2.50771426
132positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.50723949
133negative regulation of interleukin-6 production (GO:0032715)2.50554076
134cofactor catabolic process (GO:0051187)2.50240440
135antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.49547224
136B cell mediated immunity (GO:0019724)2.49288422
137glyoxylate metabolic process (GO:0046487)2.49163738
138DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.47854597
139ribosomal small subunit assembly (GO:0000028)2.47841461
140methionine metabolic process (GO:0006555)2.47463289
141methionine biosynthetic process (GO:0009086)2.46560056
142NADPH regeneration (GO:0006740)2.45323646
143intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.45271671
144signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.45271671
145sulfur amino acid catabolic process (GO:0000098)2.43832121
146regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.41377975
147oxidative phosphorylation (GO:0006119)2.41213468
148signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.37948340
149signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.37948340
150signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.37948340
151negative regulation of ligase activity (GO:0051352)2.35968525
152negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.35968525
153sulfur amino acid metabolic process (GO:0000096)2.35641052
154serine family amino acid metabolic process (GO:0009069)2.34836240
155nucleotide salvage (GO:0043173)2.34048851
156negative regulation of fatty acid biosynthetic process (GO:0045717)2.33565827
157ribosome biogenesis (GO:0042254)2.32903834
158regulation of response to interferon-gamma (GO:0060330)2.31949267
159SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.31945844
160ribosome assembly (GO:0042255)2.30858153
161bile acid biosynthetic process (GO:0006699)2.28892540
162pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.28643787
163signal transduction involved in DNA damage checkpoint (GO:0072422)2.28184119
164signal transduction involved in DNA integrity checkpoint (GO:0072401)2.28184119
165S-adenosylmethionine metabolic process (GO:0046500)2.28123200
166regulation of cholesterol esterification (GO:0010872)2.27798327
167cotranslational protein targeting to membrane (GO:0006613)2.27452419
168regulation of protein activation cascade (GO:2000257)2.27108272
169pseudouridine synthesis (GO:0001522)2.27001268
170purine nucleotide salvage (GO:0032261)2.26733985
171regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.26715322
172anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.26696351
173oxaloacetate metabolic process (GO:0006107)2.26557522
174protein targeting to ER (GO:0045047)2.26020958
175pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.25765761
176complement activation, alternative pathway (GO:0006957)2.25677451
177viral transcription (GO:0019083)2.25614181
178pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.24944216
179UMP metabolic process (GO:0046049)2.24944216
180pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.24944216
181UMP biosynthetic process (GO:0006222)2.24944216
182protein localization to endoplasmic reticulum (GO:0070972)2.24789524
183translational termination (GO:0006415)2.24655707
184nucleobase-containing small molecule interconversion (GO:0015949)2.24421615
185heme metabolic process (GO:0042168)2.23709595
186NIK/NF-kappaB signaling (GO:0038061)2.23670084
187fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.22743378
188positive regulation of ligase activity (GO:0051351)2.22724229
189antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.22366159
190aspartate family amino acid biosynthetic process (GO:0009067)2.22285223

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.74906075
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.60849620
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.59626588
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.25969250
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.17109775
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.99938217
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.93678369
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.75933069
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.64051263
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.61185644
11E2F7_22180533_ChIP-Seq_HELA_Human2.46139091
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.44576083
13* RXR_22158963_ChIP-Seq_LIVER_Mouse2.42087518
14* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.38253784
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.38206730
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.36732968
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.30898657
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.29538599
19* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.26364254
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.19830065
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.15657476
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.13558132
23IRF8_21731497_ChIP-ChIP_J774_Mouse2.11717708
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.04874515
25VDR_23849224_ChIP-Seq_CD4+_Human2.00483985
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.99659254
27* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.91599640
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.89635826
29DCP1A_22483619_ChIP-Seq_HELA_Human1.89214643
30* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88412343
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.85033544
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83385953
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81613126
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.80071808
35EGR1_23403033_ChIP-Seq_LIVER_Mouse1.79956956
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.76597091
37XRN2_22483619_ChIP-Seq_HELA_Human1.72712674
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.69777572
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.69687288
40GABP_19822575_ChIP-Seq_HepG2_Human1.66461893
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.65263832
42GATA3_26560356_Chip-Seq_TH2_Human1.64134800
43MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.63663443
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.58735597
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.58073502
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58005863
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57266595
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.55539745
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.53101494
50MYC_22102868_ChIP-Seq_BL_Human1.51948709
51FOXP3_21729870_ChIP-Seq_TREG_Human1.50468653
52* LXR_22158963_ChIP-Seq_LIVER_Mouse1.49331206
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49119192
54* SPI1_23547873_ChIP-Seq_NB4_Human1.49048279
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47252720
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.44996809
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.44519809
58BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44413081
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44076257
60RUNX_20019798_ChIP-Seq_JUKART_Human1.41817259
61HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.40029258
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39584729
63GATA3_27048872_Chip-Seq_THYMUS_Human1.39172112
64* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35931270
65AR_21909140_ChIP-Seq_LNCAP_Human1.35173834
66* SPI1_23127762_ChIP-Seq_K562_Human1.34194677
67IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33153712
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32496003
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32147645
70* TFEB_21752829_ChIP-Seq_HELA_Human1.29075284
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28719271
72VDR_24787735_ChIP-Seq_THP-1_Human1.28685480
73FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.28567026
74HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.28447217
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28127438
76CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27382763
77BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.26206648
78* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26052537
79BP1_19119308_ChIP-ChIP_Hs578T_Human1.25482421
80RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24854307
81FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.24722242
82STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24308563
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24186138
84STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23909489
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.23081419
86ELK1_19687146_ChIP-ChIP_HELA_Human1.20831550
87* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20700383
88* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20588360
89FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.19950069
90STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16996880
91PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16663185
92* PU_27001747_Chip-Seq_BMDM_Mouse1.16421241
93E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15978569
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15773583
95VDR_21846776_ChIP-Seq_THP-1_Human1.13584079
96CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12710317
97SALL4_22934838_ChIP-ChIP_CD34+_Human1.11019339
98TTF2_22483619_ChIP-Seq_HELA_Human1.09645971
99E2F4_17652178_ChIP-ChIP_JURKAT_Human1.07917956
100GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07670448
101SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07502873
102YY1_21170310_ChIP-Seq_MESCs_Mouse1.07360444
103KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06731421
104THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06015808
105ELK1_22589737_ChIP-Seq_MCF10A_Human1.05417350
106* IRF8_27001747_Chip-Seq_BMDM_Mouse1.04820165
107CLOCK_20551151_ChIP-Seq_293T_Human1.02660830
108MAF_26560356_Chip-Seq_TH1_Human1.02553471
109CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02042042
110* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01440802
111MYB_26560356_Chip-Seq_TH2_Human1.00330118
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99787997
113POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99517061
114RUNX1_22412390_ChIP-Seq_EML_Mouse0.99302575
115KDM5A_27292631_Chip-Seq_BREAST_Human0.97655746
116NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97169097
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97163063
118MYB_26560356_Chip-Seq_TH1_Human0.97060122
119* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96881841
120LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96141329
121ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95786943
122CIITA_25753668_ChIP-Seq_RAJI_Human0.94683480
123RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94673437
124CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94441858
125VDR_24763502_ChIP-Seq_THP-1_Human0.94052584
126SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92617894
127LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89398541
128CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86901462
129FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85086051
130UTX_26944678_Chip-Seq_JUKART_Human0.82156244
131PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81402754
132GATA3_26560356_Chip-Seq_TH1_Human0.81014642
133RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.79522644
134CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78959630
135ELF5_23300383_ChIP-Seq_T47D_Human0.77414759

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.53210028
2MP0003806_abnormal_nucleotide_metabolis3.81472266
3MP0005360_urolithiasis3.64690950
4MP0005365_abnormal_bile_salt2.97493239
5MP0005085_abnormal_gallbladder_physiolo2.75700355
6MP0003191_abnormal_cellular_cholesterol2.72096111
7MP0009840_abnormal_foam_cell2.67597583
8MP0003303_peritoneal_inflammation2.64761782
9MP0008260_abnormal_autophagy2.51757012
10MP0001835_abnormal_antigen_presentation2.42690363
11MP0002277_abnormal_respiratory_mucosa2.42344736
12MP0003436_decreased_susceptibility_to2.27042676
13MP0003186_abnormal_redox_activity2.26317206
14MP0009785_altered_susceptibility_to2.10949702
15MP0008875_abnormal_xenobiotic_pharmacok2.02373280
16MP0002138_abnormal_hepatobiliary_system2.01595662
17MP0003656_abnormal_erythrocyte_physiolo1.97954141
18MP0000685_abnormal_immune_system1.96390705
19MP0003724_increased_susceptibility_to1.92079877
20MP0005058_abnormal_lysosome_morphology1.90505200
21MP0005083_abnormal_biliary_tract1.89310045
22MP0005671_abnormal_response_to1.85611901
23MP0006082_CNS_inflammation1.83226366
24MP0003195_calcinosis1.77951866
25MP0005332_abnormal_amino_acid1.74767038
26MP0003300_gastrointestinal_ulcer1.74693599
27MP0006036_abnormal_mitochondrial_physio1.72507663
28MP0003693_abnormal_embryo_hatching1.71409331
29MP0005164_abnormal_response_to1.70286129
30MP0001853_heart_inflammation1.69701672
31MP0005025_abnormal_response_to1.66709744
32MP0003763_abnormal_thymus_physiology1.66579626
33MP0004883_abnormal_blood_vessel1.65716180
34MP0005000_abnormal_immune_tolerance1.65607941
35MP0009333_abnormal_splenocyte_physiolog1.65302526
36MP0000609_abnormal_liver_physiology1.61485874
37MP0010329_abnormal_lipoprotein_level1.61289420
38MP0004957_abnormal_blastocyst_morpholog1.61008332
39MP0001800_abnormal_humoral_immune1.60120976
40MP0003828_pulmonary_edema1.59218940
41MP0002419_abnormal_innate_immunity1.58233614
42MP0005319_abnormal_enzyme/_coenzyme1.52041538
43MP0008469_abnormal_protein_level1.48207719
44MP0002723_abnormal_immune_serum1.47921348
45MP0005451_abnormal_body_composition1.47484589
46MP0001545_abnormal_hematopoietic_system1.46545754
47MP0005397_hematopoietic_system_phenotyp1.46545754
48MP0002452_abnormal_antigen_presenting1.46005571
49MP0001666_abnormal_nutrient_absorption1.43429716
50MP0005464_abnormal_platelet_physiology1.42260817
51MP0001845_abnormal_inflammatory_respons1.36972718
52MP0002420_abnormal_adaptive_immunity1.33950251
53MP0002148_abnormal_hypersensitivity_rea1.33748393
54MP0001819_abnormal_immune_cell1.33226997
55MP0002398_abnormal_bone_marrow1.32737570
56MP0006054_spinal_hemorrhage1.32030260
57MP0005584_abnormal_enzyme/coenzyme_acti1.29983322
58MP0000689_abnormal_spleen_morphology1.29963669
59MP0003183_abnormal_peptide_metabolism1.28586390
60MP0000604_amyloidosis1.28214148
61MP0001790_abnormal_immune_system1.26484977
62MP0005387_immune_system_phenotype1.26484977
63MP0003448_altered_tumor_morphology1.24599902
64MP0001533_abnormal_skeleton_physiology1.24130716
65MP0001764_abnormal_homeostasis1.23864952
66MP0009764_decreased_sensitivity_to1.23809486
67MP0002405_respiratory_system_inflammati1.23313977
68MP0000716_abnormal_immune_system1.22552544
69MP0000598_abnormal_liver_morphology1.20553496
70MP0000569_abnormal_digit_pigmentation1.19459421
71MP0002722_abnormal_immune_system1.19080328
72MP0000015_abnormal_ear_pigmentation1.16416432
73MP0009763_increased_sensitivity_to1.15230328
74MP0002254_reproductive_system_inflammat1.14839827
75MP0002429_abnormal_blood_cell1.14765702
76MP0003646_muscle_fatigue1.14480746
77MP0000343_altered_response_to1.11631891
78MP0002166_altered_tumor_susceptibility1.10523262
79MP0004947_skin_inflammation1.10275777
80MP0010155_abnormal_intestine_physiology1.10167873
81MP0004381_abnormal_hair_follicle1.09982463
82MP0002118_abnormal_lipid_homeostasis1.08722615
83MP0002396_abnormal_hematopoietic_system1.06931730
84MP0005075_abnormal_melanosome_morpholog1.05824989
85MP0009643_abnormal_urine_homeostasis1.04040861
86MP0000465_gastrointestinal_hemorrhage1.02613270
87MP0003252_abnormal_bile_duct1.02460198
88MP0003172_abnormal_lysosome_physiology1.00022530
89MP0008057_abnormal_DNA_replication1.00022352
90MP0010352_gastrointestinal_tract_polyps0.98939744
91MP0000858_altered_metastatic_potential0.97995181
92MP0000490_abnormal_crypts_of0.97023220
93MP0005166_decreased_susceptibility_to0.96254120
94MP0002933_joint_inflammation0.94974977
95MP0009765_abnormal_xenobiotic_induced0.90271808
96MP0005636_abnormal_mineral_homeostasis0.89221203
97MP0002019_abnormal_tumor_incidence0.87472050
98MP0003221_abnormal_cardiomyocyte_apopto0.87213767
99MP0003786_premature_aging0.85567801
100MP0006035_abnormal_mitochondrial_morpho0.85444952
101MP0005220_abnormal_exocrine_pancreas0.85114534
102MP0003866_abnormal_defecation0.85015834
103MP0003077_abnormal_cell_cycle0.84466037
104MP0005266_abnormal_metabolism0.84196065
105MP0001851_eye_inflammation0.83915746
106MP0002006_tumorigenesis0.83313602
107MP0003705_abnormal_hypodermis_morpholog0.81946638
108MP0008058_abnormal_DNA_repair0.81698408
109MP0000703_abnormal_thymus_morphology0.80614386
110MP0001873_stomach_inflammation0.80430526
111MP0004130_abnormal_muscle_cell0.80241670
112MP0005023_abnormal_wound_healing0.80127433
113MP0005084_abnormal_gallbladder_morpholo0.79704622
114MP0002971_abnormal_brown_adipose0.78371764
115MP0005376_homeostasis/metabolism_phenot0.76724162
116MP0002998_abnormal_bone_remodeling0.76461689
117MP0008873_increased_physiological_sensi0.76056818
118MP0008004_abnormal_stomach_pH0.75856083
119MP0000371_diluted_coat_color0.75684696
120MP0005670_abnormal_white_adipose0.75284966
121MP0002095_abnormal_skin_pigmentation0.74160062
122MP0004510_myositis0.73736706
123MP0003718_maternal_effect0.73184832
124MP0005310_abnormal_salivary_gland0.72788109
125MP0003075_altered_response_to0.71862162
126MP0002132_abnormal_respiratory_system0.70926267
127MP0005174_abnormal_tail_pigmentation0.65635148
128MP0002332_abnormal_exercise_endurance0.65349691
129MP0000516_abnormal_urinary_system0.61960861
130MP0005367_renal/urinary_system_phenotyp0.61960861

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)5.15806447
2Abnormality of macrophages (HP:0004311)5.09076537
3Stomatitis (HP:0010280)4.77088478
4Orchitis (HP:0100796)4.73310547
5Optic neuritis (HP:0100653)4.69073625
6Retrobulbar optic neuritis (HP:0100654)4.69073625
7Abnormality of aromatic amino acid family metabolism (HP:0004338)4.14086256
8Anorexia (HP:0002039)3.68536212
9Keratoconjunctivitis sicca (HP:0001097)3.58531257
10Recurrent skin infections (HP:0001581)3.54137583
11Decreased activity of mitochondrial respiratory chain (HP:0008972)3.41771252
12Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.41771252
13Gastrointestinal infarctions (HP:0005244)3.33423725
14Keratoconjunctivitis (HP:0001096)3.30382598
15Spontaneous hematomas (HP:0007420)3.28207489
16Hypochromic microcytic anemia (HP:0004840)3.26512812
17Mediastinal lymphadenopathy (HP:0100721)3.23602735
18Xanthomatosis (HP:0000991)3.18337033
19Abnormality of T cell number (HP:0011839)3.15817789
20Encephalitis (HP:0002383)3.10855991
21T lymphocytopenia (HP:0005403)3.07329002
22Recurrent fungal infections (HP:0002841)3.03557999
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.02687727
24Hypobetalipoproteinemia (HP:0003563)2.99658846
25Vacuolated lymphocytes (HP:0001922)2.89198114
26Abnormality of monocarboxylic acid metabolism (HP:0010996)2.87063968
27Ragged-red muscle fibers (HP:0003200)2.86191859
28Multiple enchondromatosis (HP:0005701)2.83352254
29Chronic obstructive pulmonary disease (HP:0006510)2.82559330
30Obstructive lung disease (HP:0006536)2.82559330
31Hypoglycemic coma (HP:0001325)2.80727760
32Meningitis (HP:0001287)2.80390530
33Leukocytosis (HP:0001974)2.78435825
34Hyperammonemia (HP:0001987)2.78373557
35Vasculitis (HP:0002633)2.77993173
36Hyperlipoproteinemia (HP:0010980)2.76294738
37Peritonitis (HP:0002586)2.75493830
38Arterial thrombosis (HP:0004420)2.75165069
39Elevated erythrocyte sedimentation rate (HP:0003565)2.74243041
40Hepatic necrosis (HP:0002605)2.74058124
41Intrahepatic cholestasis (HP:0001406)2.74006527
42Pulmonary infiltrates (HP:0002113)2.72653795
43Abnormality of alanine metabolism (HP:0010916)2.70720672
44Hyperalaninemia (HP:0003348)2.70720672
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.70720672
46Nausea (HP:0002018)2.69496133
47Hemoptysis (HP:0002105)2.69159533
48Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.66912262
49Abnormality of transition element cation homeostasis (HP:0011030)2.65156816
50Generalized aminoaciduria (HP:0002909)2.65086356
51Increased serum ferritin (HP:0003281)2.63091082
52Increased serum pyruvate (HP:0003542)2.62938430
53Abnormality of glycolysis (HP:0004366)2.62938430
54Deep venous thrombosis (HP:0002625)2.60090949
55Gingivitis (HP:0000230)2.58188111
56Abnormality of iron homeostasis (HP:0011031)2.57217416
57Recurrent cutaneous fungal infections (HP:0011370)2.56961243
58Chronic mucocutaneous candidiasis (HP:0002728)2.56961243
59Recurrent gram-negative bacterial infections (HP:0005420)2.56023046
60Episodic fever (HP:0001954)2.55979129
61Increased IgM level (HP:0003496)2.55834752
62Abnormality of fatty-acid metabolism (HP:0004359)2.55661355
63Abnormality of methionine metabolism (HP:0010901)2.53918771
64Hyperglycinemia (HP:0002154)2.49318134
65Abnormality of T cells (HP:0002843)2.47499605
66Pulmonary embolism (HP:0002204)2.47127657
67Gangrene (HP:0100758)2.46777009
68Granulocytopenia (HP:0001913)2.46385740
69Increased muscle lipid content (HP:0009058)2.46267915
70Lipid accumulation in hepatocytes (HP:0006561)2.44979994
71Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.44386723
72Prolonged partial thromboplastin time (HP:0003645)2.39636381
73Abnormality of serum amino acid levels (HP:0003112)2.38620955
74Constricted visual fields (HP:0001133)2.37977796
75Abnormality of sulfur amino acid metabolism (HP:0004339)2.35787913
76Abnormality of dicarboxylic acid metabolism (HP:0010995)2.35074741
77Dicarboxylic aciduria (HP:0003215)2.35074741
78Petechiae (HP:0000967)2.34149774
79Complement deficiency (HP:0004431)2.33989806
80Ketosis (HP:0001946)2.33164111
81Abnormality of the common coagulation pathway (HP:0010990)2.32763079
82Abnormality of aspartate family amino acid metabolism (HP:0010899)2.32604380
83Hypergammaglobulinemia (HP:0010702)2.32507640
84Hyperglycinuria (HP:0003108)2.29431012
85Lactic acidosis (HP:0003128)2.28456972
86Autoimmune thrombocytopenia (HP:0001973)2.28189536
87Hypoplasia of the thymus (HP:0000778)2.27911155
88Hepatocellular necrosis (HP:0001404)2.27906376
89Systemic lupus erythematosus (HP:0002725)2.27016315
90Increased serum lactate (HP:0002151)2.25947453
91Chest pain (HP:0100749)2.25455534
92Hypochromic anemia (HP:0001931)2.25419036
93Eosinophilia (HP:0001880)2.24700080
94Abnormal number of erythroid precursors (HP:0012131)2.24620679
95Increased intramyocellular lipid droplets (HP:0012240)2.24467033
96Cerebral edema (HP:0002181)2.23276786
97Abnormality of liposaccharide metabolism (HP:0010968)2.23181861
98Abnormality of glycosphingolipid metabolism (HP:0004343)2.23181861
99Abnormality of glycolipid metabolism (HP:0010969)2.23181861
100Acute hepatic failure (HP:0006554)2.22636663
101Abnormality of glycine metabolism (HP:0010895)2.21867432
102Abnormality of serine family amino acid metabolism (HP:0010894)2.21867432
103Eczematoid dermatitis (HP:0000976)2.21051924
104Abnormality of eosinophils (HP:0001879)2.20840296
105Increased CSF lactate (HP:0002490)2.20377242
106Aplastic anemia (HP:0001915)2.19271729
107Abnormality of the fetal cardiovascular system (HP:0010948)2.19168697
108Abnormal umbilical cord blood vessels (HP:0011403)2.19168697
109Single umbilical artery (HP:0001195)2.19168697
110Acute encephalopathy (HP:0006846)2.18438202
111Lethargy (HP:0001254)2.17723036
112Fatigue (HP:0012378)2.17540760
113Increased hepatocellular lipid droplets (HP:0006565)2.15369649
114Reduced antithrombin III activity (HP:0001976)2.14145141
115Pustule (HP:0200039)2.13497466
116Abnormality of cells of the erythroid lineage (HP:0012130)2.10226058
117Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.10007670
118Abnormal cartilage morphology (HP:0002763)2.09843622
119Mitochondrial inheritance (HP:0001427)2.09833610
120Acanthocytosis (HP:0001927)2.08717846
121Microcytic anemia (HP:0001935)2.08468337
122Urticaria (HP:0001025)2.07887566
123Oral leukoplakia (HP:0002745)2.07331202
124Abnormality of T cell physiology (HP:0011840)2.07220229
125Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.06729261
126Hypolipoproteinemia (HP:0010981)2.06187037
127Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.06122411
128Fat malabsorption (HP:0002630)2.04900905
129Purpura (HP:0000979)2.04883959
130Recurrent bacterial skin infections (HP:0005406)2.04861706
1313-Methylglutaconic aciduria (HP:0003535)2.04639191
132Abnormality of glutamine family amino acid metabolism (HP:0010902)2.04234457
133Hyperbilirubinemia (HP:0002904)2.02908680
134Increased IgE level (HP:0003212)2.02464645
135Recurrent abscess formation (HP:0002722)2.02178617
136Abnormality of the heme biosynthetic pathway (HP:0010472)2.01493842
137Global brain atrophy (HP:0002283)2.01426840
138Exertional dyspnea (HP:0002875)2.01347666
139Abnormality of the intrinsic pathway (HP:0010989)2.00565408
140Myocardial infarction (HP:0001658)1.98423076
141Opisthotonus (HP:0002179)1.97692488
142Combined immunodeficiency (HP:0005387)1.97047772
143Gingival bleeding (HP:0000225)1.96911554
144Acute necrotizing encephalopathy (HP:0006965)1.96378327
145Abnormality of the basal ganglia (HP:0002134)1.95910790
146Abnormal mitochondria in muscle tissue (HP:0008316)1.95005046
147Keratitis (HP:0000491)1.94547344
148Epidermoid cyst (HP:0200040)1.93756521
149Thrombophlebitis (HP:0004418)1.93669280
150Hepatosplenomegaly (HP:0001433)1.92917933
151Recurrent viral infections (HP:0004429)1.92336411
152Parakeratosis (HP:0001036)1.91979717
153IgM deficiency (HP:0002850)1.90350836
154Epistaxis (HP:0000421)1.89730636
155Increased neuronal autofluorescent lipopigment (HP:0002074)1.89287683
156Lymphopenia (HP:0001888)1.88844190
157Steatorrhea (HP:0002570)1.88835621
158Renal Fanconi syndrome (HP:0001994)1.88480527
159Polyneuropathy (HP:0001271)1.88006738
160Osteomyelitis (HP:0002754)1.87117991
161Glycosuria (HP:0003076)1.87067859
162Abnormality of urine glucose concentration (HP:0011016)1.87067859
163Axonal loss (HP:0003447)1.86941539
164Birth length less than 3rd percentile (HP:0003561)1.86138169
165Chronic otitis media (HP:0000389)1.85872192
166Autoimmune hemolytic anemia (HP:0001890)1.85748078
167Loss of speech (HP:0002371)1.84694645
168Abnormality of the peritoneum (HP:0002585)1.81490570
169Amaurosis fugax (HP:0100576)1.80084825
170Sepsis (HP:0100806)1.79887651
171Degeneration of anterior horn cells (HP:0002398)1.79505363
172Abnormality of the anterior horn cell (HP:0006802)1.79505363
173Abnormality of cells of the lymphoid lineage (HP:0012140)1.78825279
174Premature loss of primary teeth (HP:0006323)1.75687214
175Skin ulcer (HP:0200042)1.75023313
176Toxemia of pregnancy (HP:0100603)1.72850645
177Abnormality of the pericardium (HP:0001697)1.71708677
178Disinhibition (HP:0000734)1.71527677

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.89086706
2ERN13.33220365
3EIF2AK13.14760412
4BCKDK3.07988347
5MAP4K12.60344296
6KDR2.50021874
7TESK22.48695056
8FGR2.47759781
9ACVR1B2.37857216
10BLK2.37010794
11MAP3K132.28933773
12ZAP702.16899886
13WEE12.01576552
14TYK21.99612819
15TBK11.97323135
16TRIM281.97074534
17EIF2AK31.94675366
18PIM21.92045294
19SCYL21.77717576
20ARAF1.77356112
21EPHB11.70124326
22RIPK41.65999418
23BUB11.65055445
24SIK31.63131806
25PBK1.60303951
26CDK191.59051042
27FLT31.58989690
28MAP3K111.58921289
29RPS6KA41.53093237
30YES11.53053345
31NEK91.52134563
32PDK21.52060564
33TAOK31.49817627
34FES1.49536242
35MAP2K31.45600770
36MAP3K141.43363202
37MAP3K31.41087787
38TXK1.39792362
39JAK31.36878057
40KIT1.31381500
41ABL21.31147580
42FGFR41.29657409
43BMPR21.29567557
44RAF11.29364095
45PAK41.23335341
46BRSK21.19948234
47TEC1.19166312
48HCK1.17698263
49IKBKB1.17540555
50IRAK11.16881935
51STK101.15712891
52DYRK31.15707883
53MAPKAPK31.12971339
54MOS1.11001002
55MAP3K21.10145043
56NLK1.07778428
57GRK61.03869039
58SYK1.01624266
59IRAK31.00279509
60LRRK20.97463772
61MST40.97082588
62STK160.96521231
63IKBKE0.95611559
64MAP3K80.93706341
65KSR10.93090838
66CDK40.92326816
67TRIB30.92272800
68TNK20.88592586
69BRAF0.87640697
70TSSK60.87308999
71MAP3K10.87121740
72KSR20.86689437
73SRPK10.85908839
74PTK2B0.82351761
75MAPK110.78917483
76NEK20.78549475
77BCR0.78202149
78CLK10.77728990
79LYN0.77074213
80STK240.76968856
81IRAK20.75789309
82TAOK10.75129952
83BTK0.74050377
84OXSR10.73604041
85NME10.73570376
86CDK80.72487423
87PLK30.71475048
88IRAK40.70946827
89FRK0.70734221
90MATK0.70017406
91NUAK10.69466427
92TGFBR10.69313962
93PIM10.69105469
94PKN20.68149134
95MAP3K120.67233859
96CSF1R0.64722451
97LCK0.64400966
98GRK70.64206829
99STK38L0.58161021
100STK30.57756939
101CHUK0.57266047
102JAK20.56679000
103PRKCQ0.55878414
104JAK10.55609806
105CSK0.54299905
106TAOK20.54266711
107BMPR1B0.53988533
108MAP3K50.53202331
109ERBB40.52540508
110EGFR0.51123830
111TGFBR20.47775053
112CDK70.47193030
113CDC70.46585970
114PIK3CG0.44621355
115PAK30.43464814
116MAPKAPK20.43243572
117TESK10.43122093
118PRPF4B0.42338794
119PLK10.42186125
120ITK0.41112099
121ALK0.40676340
122CAMKK20.39786558
123MAP3K90.39699284
124MARK30.38519741
125CDK60.38033720
126STK40.37817692
127PRKCD0.36327180
128CSNK2A20.36279073
129VRK10.36065632
130AURKB0.35992325
131NEK60.35050870
132TLK10.34685911
133RPS6KB20.32912720
134SIK10.32796298
135AURKA0.32665704
136CSNK2A10.32532152
137ABL10.29659127
138EIF2AK20.29461941
139PLK20.29362910
140PAK10.29062847
141PTK60.28077763
142TAF10.27931446

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.33794914
2Osteoclast differentiation_Homo sapiens_hsa043802.65115474
3Folate biosynthesis_Homo sapiens_hsa007902.48145054
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.36944878
5NOD-like receptor signaling pathway_Homo sapiens_hsa046212.26607446
6Caffeine metabolism_Homo sapiens_hsa002322.23652232
7Ribosome_Homo sapiens_hsa030102.15397821
8Tuberculosis_Homo sapiens_hsa051522.07374659
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.07247836
10Sulfur relay system_Homo sapiens_hsa041222.04074915
11Collecting duct acid secretion_Homo sapiens_hsa049662.02587651
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.01047564
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.96790406
14Drug metabolism - other enzymes_Homo sapiens_hsa009831.93593880
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.91167282
16Selenocompound metabolism_Homo sapiens_hsa004501.89458813
17Malaria_Homo sapiens_hsa051441.89145418
18DNA replication_Homo sapiens_hsa030301.88746560
19Autoimmune thyroid disease_Homo sapiens_hsa053201.83737556
20RNA polymerase_Homo sapiens_hsa030201.83650514
21Rheumatoid arthritis_Homo sapiens_hsa053231.82372132
22Protein export_Homo sapiens_hsa030601.74397779
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.73490244
24Pyrimidine metabolism_Homo sapiens_hsa002401.68984032
25Staphylococcus aureus infection_Homo sapiens_hsa051501.67407653
26Phagosome_Homo sapiens_hsa041451.67323744
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.67168241
28Hematopoietic cell lineage_Homo sapiens_hsa046401.65653298
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.65281888
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.64306071
31Type I diabetes mellitus_Homo sapiens_hsa049401.62465369
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.61939190
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.60509538
34Pentose phosphate pathway_Homo sapiens_hsa000301.57397015
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.56822148
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55717929
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.55216241
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53773480
39Fatty acid degradation_Homo sapiens_hsa000711.52526958
40Influenza A_Homo sapiens_hsa051641.50714211
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.50315417
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.49812129
43Chemokine signaling pathway_Homo sapiens_hsa040621.47681109
44Peroxisome_Homo sapiens_hsa041461.47204555
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.45544854
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.44039732
47Propanoate metabolism_Homo sapiens_hsa006401.39537626
48Carbon metabolism_Homo sapiens_hsa012001.38141853
49African trypanosomiasis_Homo sapiens_hsa051431.37775817
50Basal transcription factors_Homo sapiens_hsa030221.36620529
51Complement and coagulation cascades_Homo sapiens_hsa046101.35542861
52One carbon pool by folate_Homo sapiens_hsa006701.33096638
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.31777059
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31707703
55Mismatch repair_Homo sapiens_hsa034301.29434607
56Biosynthesis of amino acids_Homo sapiens_hsa012301.27000299
57Pertussis_Homo sapiens_hsa051331.25069615
58Jak-STAT signaling pathway_Homo sapiens_hsa046301.24522744
59Oxidative phosphorylation_Homo sapiens_hsa001901.23758508
60TNF signaling pathway_Homo sapiens_hsa046681.21714422
61Tryptophan metabolism_Homo sapiens_hsa003801.20127878
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.20072400
63Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16461121
64Arginine biosynthesis_Homo sapiens_hsa002201.15681916
65Pyruvate metabolism_Homo sapiens_hsa006201.15258565
66Base excision repair_Homo sapiens_hsa034101.13980135
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13922097
68T cell receptor signaling pathway_Homo sapiens_hsa046601.12618307
69Parkinsons disease_Homo sapiens_hsa050121.10871827
70Toxoplasmosis_Homo sapiens_hsa051451.08888828
71B cell receptor signaling pathway_Homo sapiens_hsa046621.08679409
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08565250
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08283981
74Antigen processing and presentation_Homo sapiens_hsa046121.07831804
75Salmonella infection_Homo sapiens_hsa051321.06666355
76Legionellosis_Homo sapiens_hsa051341.05563836
77beta-Alanine metabolism_Homo sapiens_hsa004101.04847831
78PPAR signaling pathway_Homo sapiens_hsa033201.03536201
79Viral myocarditis_Homo sapiens_hsa054161.01335497
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.00901265
81Nucleotide excision repair_Homo sapiens_hsa034200.97913016
82Hepatitis B_Homo sapiens_hsa051610.96127000
83RNA transport_Homo sapiens_hsa030130.93519336
84Histidine metabolism_Homo sapiens_hsa003400.92952581
85Nitrogen metabolism_Homo sapiens_hsa009100.92463437
86Leishmaniasis_Homo sapiens_hsa051400.86483166
87Sulfur metabolism_Homo sapiens_hsa009200.85345305
88Glutathione metabolism_Homo sapiens_hsa004800.84142490
89Primary immunodeficiency_Homo sapiens_hsa053400.83851767
90Phenylalanine metabolism_Homo sapiens_hsa003600.81766621
91Spliceosome_Homo sapiens_hsa030400.81349047
92Arginine and proline metabolism_Homo sapiens_hsa003300.80899123
93Other glycan degradation_Homo sapiens_hsa005110.78327470
94Chemical carcinogenesis_Homo sapiens_hsa052040.77811830
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77349617
96Fatty acid metabolism_Homo sapiens_hsa012120.76471273
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.76471065
98Lysosome_Homo sapiens_hsa041420.74009634
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72856489
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72696444
101Fat digestion and absorption_Homo sapiens_hsa049750.70747240
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69777002
103Hepatitis C_Homo sapiens_hsa051600.69709091
104Homologous recombination_Homo sapiens_hsa034400.69291133
105Starch and sucrose metabolism_Homo sapiens_hsa005000.68930232
106Huntingtons disease_Homo sapiens_hsa050160.67553686
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.66759649
108Measles_Homo sapiens_hsa051620.64892512
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64149074
110Herpes simplex infection_Homo sapiens_hsa051680.64134966
111Viral carcinogenesis_Homo sapiens_hsa052030.64018591
112Shigellosis_Homo sapiens_hsa051310.63849975
113Metabolic pathways_Homo sapiens_hsa011000.63524354
114Galactose metabolism_Homo sapiens_hsa000520.63171158
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63102259
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62931457
117Acute myeloid leukemia_Homo sapiens_hsa052210.62597943
118Vibrio cholerae infection_Homo sapiens_hsa051100.59434638
119Asthma_Homo sapiens_hsa053100.57305413
120Alzheimers disease_Homo sapiens_hsa050100.57012076
121Fatty acid elongation_Homo sapiens_hsa000620.56919415
122Epstein-Barr virus infection_Homo sapiens_hsa051690.56842262
123Maturity onset diabetes of the young_Homo sapiens_hsa049500.56722121
124Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56458516
125Tyrosine metabolism_Homo sapiens_hsa003500.53856151
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53109246
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51620247
128p53 signaling pathway_Homo sapiens_hsa041150.51099582
129Intestinal immune network for IgA production_Homo sapiens_hsa046720.50467234
130Regulation of autophagy_Homo sapiens_hsa041400.49877549
131Apoptosis_Homo sapiens_hsa042100.48549014
132RNA degradation_Homo sapiens_hsa030180.45984203
133Graft-versus-host disease_Homo sapiens_hsa053320.45696832
134Purine metabolism_Homo sapiens_hsa002300.45408593
135Fructose and mannose metabolism_Homo sapiens_hsa000510.45361658
136Allograft rejection_Homo sapiens_hsa053300.45025405
137Endocytosis_Homo sapiens_hsa041440.44518450
138Thyroid cancer_Homo sapiens_hsa052160.42236827
139Glycerolipid metabolism_Homo sapiens_hsa005610.41687251
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41229185
141Vitamin B6 metabolism_Homo sapiens_hsa007500.40672365
142Non-homologous end-joining_Homo sapiens_hsa034500.40347137
143HIF-1 signaling pathway_Homo sapiens_hsa040660.39293239
144Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36446681
145FoxO signaling pathway_Homo sapiens_hsa040680.34962965
146Pancreatic cancer_Homo sapiens_hsa052120.31756293
147Renal cell carcinoma_Homo sapiens_hsa052110.30401408
148Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27897465
149Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27775685
150Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27285098
151Sphingolipid signaling pathway_Homo sapiens_hsa040710.26980024
152Mineral absorption_Homo sapiens_hsa049780.25364213
153HTLV-I infection_Homo sapiens_hsa051660.21723698
154Platelet activation_Homo sapiens_hsa046110.20317015

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