NRBF2P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)8.09646839
2RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)8.09646839
3homocysteine metabolic process (GO:0050667)6.27596012
4purine nucleotide salvage (GO:0032261)5.73497390
5ribosomal small subunit assembly (GO:0000028)5.69570203
6sulfur amino acid catabolic process (GO:0000098)5.36233945
7regulation of plasminogen activation (GO:0010755)5.27678789
8folic acid-containing compound biosynthetic process (GO:0009396)5.04226338
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.92698016
10mitochondrial respiratory chain complex I assembly (GO:0032981)4.92698016
11NADH dehydrogenase complex assembly (GO:0010257)4.92698016
12maturation of SSU-rRNA (GO:0030490)4.91030361
13adenosine metabolic process (GO:0046085)4.84404897
14negative regulation of DNA biosynthetic process (GO:2000279)4.57580229
15protein complex biogenesis (GO:0070271)4.48317993
16white fat cell differentiation (GO:0050872)4.46358679
17epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.40639821
18cysteine metabolic process (GO:0006534)4.37327851
19positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.25281337
20tachykinin receptor signaling pathway (GO:0007217)4.21745643
21behavioral response to nicotine (GO:0035095)4.20039874
22negative regulation of catenin import into nucleus (GO:0035414)4.17630934
23microtubule nucleation (GO:0007020)4.16939621
24protein-cofactor linkage (GO:0018065)4.01397266
25mitochondrial respiratory chain complex assembly (GO:0033108)3.90082661
26mitochondrial RNA metabolic process (GO:0000959)3.77890322
27cochlea development (GO:0090102)3.74643627
28pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.70810726
29negative regulation of Ras GTPase activity (GO:0034261)3.70557872
30negative regulation of keratinocyte proliferation (GO:0010839)3.59005662
31pteridine-containing compound biosynthetic process (GO:0042559)3.58730824
32cilium or flagellum-dependent cell motility (GO:0001539)3.56709710
33regulation of gonadotropin secretion (GO:0032276)3.53381127
34protein localization to vacuole (GO:0072665)3.52629416
35protein localization to lysosome (GO:0061462)3.52629416
36regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.51099388
37regulation of response to food (GO:0032095)3.48723413
38protein targeting to lysosome (GO:0006622)3.45215886
39establishment of protein localization to vacuole (GO:0072666)3.45215886
40protein targeting to vacuole (GO:0006623)3.45215886
41alternative mRNA splicing, via spliceosome (GO:0000380)3.40788397
42mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.40631824
43negative regulation of response to food (GO:0032096)3.37136936
44negative regulation of appetite (GO:0032099)3.37136936
45galactose metabolic process (GO:0006012)3.36776467
46chaperone-mediated protein transport (GO:0072321)3.34871537
47axonemal dynein complex assembly (GO:0070286)3.34664086
48neurofilament cytoskeleton organization (GO:0060052)3.34473106
49behavioral fear response (GO:0001662)3.30851567
50behavioral defense response (GO:0002209)3.30851567
51ribosome biogenesis (GO:0042254)3.29983560
52positive regulation of interleukin-17 production (GO:0032740)3.29293184
53activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.27690356
54negative regulation of response to extracellular stimulus (GO:0032105)3.26952873
55negative regulation of response to nutrient levels (GO:0032108)3.26952873
56purine-containing compound salvage (GO:0043101)3.25714166
57inner ear receptor cell development (GO:0060119)3.23455317
58inner mitochondrial membrane organization (GO:0007007)3.17601054
59establishment of mitochondrion localization (GO:0051654)3.16819016
60nucleotide salvage (GO:0043173)3.15739972
61regulation of vitamin D biosynthetic process (GO:0060556)3.15500410
62cellular component biogenesis (GO:0044085)3.13118590
63positive regulation of endothelial cell differentiation (GO:0045603)3.12625249
64epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.09520659
65single strand break repair (GO:0000012)3.07625104
66negative regulation of heart rate (GO:0010459)3.06927536
67histone H4-K12 acetylation (GO:0043983)3.05520137
68regulation of sequestering of triglyceride (GO:0010889)3.03265320
69negative regulation of telomerase activity (GO:0051974)3.01713156
70rRNA methylation (GO:0031167)3.00196102
71IMP biosynthetic process (GO:0006188)2.98121931
72pyrimidine nucleotide catabolic process (GO:0006244)2.97144290
73positive regulation of oligodendrocyte differentiation (GO:0048714)2.96852842
74regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.94826566
75substrate-independent telencephalic tangential migration (GO:0021826)2.93265852
76substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.93265852
77regulation of appetite (GO:0032098)2.91793198
78primary amino compound metabolic process (GO:1901160)2.91767037
79tRNA processing (GO:0008033)2.87182196
80protein-chromophore linkage (GO:0018298)2.86260164
81CENP-A containing nucleosome assembly (GO:0034080)2.86252400
82regulation of cilium movement (GO:0003352)2.85725141
83respiratory electron transport chain (GO:0022904)2.84596130
84rRNA modification (GO:0000154)2.83797374
85innervation (GO:0060384)2.83295085
86fear response (GO:0042596)2.81477996
87electron transport chain (GO:0022900)2.80893299
88ribonucleoprotein complex biogenesis (GO:0022613)2.78650172
89superoxide anion generation (GO:0042554)2.76181860
90estrogen biosynthetic process (GO:0006703)2.74585447
91hydrogen peroxide biosynthetic process (GO:0050665)2.72733329
92L-serine metabolic process (GO:0006563)2.72317825
93positive regulation of respiratory burst (GO:0060267)2.72212754
94regulation of telomerase activity (GO:0051972)2.70639990
95respiratory chain complex IV assembly (GO:0008535)2.69125612
96polyamine biosynthetic process (GO:0006596)2.67266157
97IMP metabolic process (GO:0046040)2.66404913
98cytochrome complex assembly (GO:0017004)2.65207386
99chromatin remodeling at centromere (GO:0031055)2.65151297
100regulation of isotype switching to IgG isotypes (GO:0048302)2.63289902

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse9.08252929
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.22161289
3EZH2_22144423_ChIP-Seq_EOC_Human4.88110174
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.77159658
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.65722818
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.83676909
7VDR_22108803_ChIP-Seq_LS180_Human2.80074772
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.70467825
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.48070093
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.39707181
11ZNF274_21170338_ChIP-Seq_K562_Hela2.21909568
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94590843
13ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93564381
14EST1_17652178_ChIP-ChIP_JURKAT_Human1.87562600
15GATA1_26923725_Chip-Seq_HPCs_Mouse1.76971314
16TP53_22573176_ChIP-Seq_HFKS_Human1.73289030
17ETS1_20019798_ChIP-Seq_JURKAT_Human1.63426353
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.62698515
19BCAT_22108803_ChIP-Seq_LS180_Human1.62427647
20POU5F1_16153702_ChIP-ChIP_HESCs_Human1.60336248
21VDR_23849224_ChIP-Seq_CD4+_Human1.55977531
22GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.43939498
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43805057
24NCOR_22424771_ChIP-Seq_293T_Human1.42173020
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42093715
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.41555850
27ETV2_25802403_ChIP-Seq_MESCs_Mouse1.39547025
28TAF15_26573619_Chip-Seq_HEK293_Human1.39378300
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38995231
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37399203
31CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.35190488
32YY1_22570637_ChIP-Seq_MALME-3M_Human1.34390725
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.34355341
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.32155873
35FOXP3_21729870_ChIP-Seq_TREG_Human1.31722156
36REST_21632747_ChIP-Seq_MESCs_Mouse1.30421305
37STAT1_20625510_ChIP-Seq_HELA_Human1.26823990
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25369056
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22925911
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20073358
41P300_19829295_ChIP-Seq_ESCs_Human1.19263982
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.18553044
43KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16522767
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15902625
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15623882
46TCF4_22108803_ChIP-Seq_LS180_Human1.14476660
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14446871
48FUS_26573619_Chip-Seq_HEK293_Human1.12319917
49ELK1_19687146_ChIP-ChIP_HELA_Human1.11464843
50IRF8_22096565_ChIP-ChIP_GC-B_Human1.11036154
51IRF1_19129219_ChIP-ChIP_H3396_Human1.10173701
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09967663
53EED_16625203_ChIP-ChIP_MESCs_Mouse1.09275401
54CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07191496
55ERG_20517297_ChIP-Seq_VCAP_Human1.05754749
56PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03336739
57CDX2_22108803_ChIP-Seq_LS180_Human1.01911751
58RNF2_27304074_Chip-Seq_NSC_Mouse1.01349574
59JARID2_20064375_ChIP-Seq_MESCs_Mouse1.01229501
60FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00735074
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.00735074
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00667983
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99937718
64CBP_20019798_ChIP-Seq_JUKART_Human0.99937718
65SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98937135
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98651134
67GABP_19822575_ChIP-Seq_HepG2_Human0.98441669
68FLI1_27457419_Chip-Seq_LIVER_Mouse0.97581189
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97322514
70NANOG_20526341_ChIP-Seq_ESCs_Human0.95792786
71HOXB7_26014856_ChIP-Seq_BT474_Human0.94293591
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93425528
73PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93203972
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93010056
75CBX2_27304074_Chip-Seq_ESCs_Mouse0.92860640
76TAF2_19829295_ChIP-Seq_ESCs_Human0.90593012
77POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89807174
78FOXH1_21741376_ChIP-Seq_ESCs_Human0.89442515
79EWS_26573619_Chip-Seq_HEK293_Human0.89255066
80EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.87987035
81RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.87749665
82MYC_19829295_ChIP-Seq_ESCs_Human0.87732519
83FOXH1_21741376_ChIP-Seq_EPCs_Human0.87477417
84SOX2_19829295_ChIP-Seq_ESCs_Human0.86483241
85NANOG_19829295_ChIP-Seq_ESCs_Human0.86483241
86SOX2_16153702_ChIP-ChIP_HESCs_Human0.85970704
87GATA3_21867929_ChIP-Seq_TH1_Mouse0.85915126
88XRN2_22483619_ChIP-Seq_HELA_Human0.85827753
89SUZ12_27294783_Chip-Seq_ESCs_Mouse0.85775572
90RNF2_27304074_Chip-Seq_ESCs_Mouse0.84141084
91FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84052141
92GATA3_21878914_ChIP-Seq_MCF-7_Human0.83915659
93PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.83591868
94TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83437059
95OCT1_27270436_Chip-Seq_PROSTATE_Human0.82676822
96EZH2_27294783_Chip-Seq_NPCs_Mouse0.81811079
97SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.80944951
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79113572
99CTBP2_25329375_ChIP-Seq_LNCAP_Human0.78975083
100RUNX2_22187159_ChIP-Seq_PCA_Human0.78335640

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.11174690
2MP0003787_abnormal_imprinting3.43590756
3MP0000013_abnormal_adipose_tissue3.43572343
4MP0004885_abnormal_endolymph2.74403981
5MP0005670_abnormal_white_adipose2.64126243
6MP0008995_early_reproductive_senescence2.57432502
7MP0002938_white_spotting2.56678365
8MP0005360_urolithiasis2.49099398
9MP0002735_abnormal_chemical_nociception2.44240552
10MP0003880_abnormal_central_pattern2.39011834
11MP0005646_abnormal_pituitary_gland2.32717727
12MP0005367_renal/urinary_system_phenotyp2.28068399
13MP0000516_abnormal_urinary_system2.28068399
14MP0002736_abnormal_nociception_after2.26180628
15MP0003806_abnormal_nucleotide_metabolis2.22278574
16MP0001968_abnormal_touch/_nociception2.10593370
17MP0001661_extended_life_span2.04997820
18MP0006072_abnormal_retinal_apoptosis1.99456991
19MP0001440_abnormal_grooming_behavior1.91274462
20MP0002095_abnormal_skin_pigmentation1.88076583
21MP0004147_increased_porphyrin_level1.87506931
22MP0006292_abnormal_olfactory_placode1.78904203
23MP0002876_abnormal_thyroid_physiology1.72460616
24MP0004133_heterotaxia1.65138112
25MP0005551_abnormal_eye_electrophysiolog1.64316318
26MP0001502_abnormal_circadian_rhythm1.61381376
27MP0005332_abnormal_amino_acid1.60741653
28MP0005253_abnormal_eye_physiology1.59496351
29MP0003724_increased_susceptibility_to1.54335442
30MP0006276_abnormal_autonomic_nervous1.54027665
31MP0008872_abnormal_physiological_respon1.52966439
32MP0003011_delayed_dark_adaptation1.48374567
33MP0008789_abnormal_olfactory_epithelium1.46494054
34MP0004142_abnormal_muscle_tone1.45907524
35MP0001905_abnormal_dopamine_level1.45537044
36MP0009053_abnormal_anal_canal1.41327951
37MP0003183_abnormal_peptide_metabolism1.40326413
38MP0003890_abnormal_embryonic-extraembry1.38453882
39MP0000569_abnormal_digit_pigmentation1.36749433
40MP0002184_abnormal_innervation1.36396150
41MP0002160_abnormal_reproductive_system1.34768278
42MP0003186_abnormal_redox_activity1.34260236
43MP0001756_abnormal_urination1.33102300
44MP0002837_dystrophic_cardiac_calcinosis1.26356138
45MP0009745_abnormal_behavioral_response1.26301366
46MP0005499_abnormal_olfactory_system1.24215247
47MP0005394_taste/olfaction_phenotype1.24215247
48MP0003123_paternal_imprinting1.22230609
49MP0000534_abnormal_ureter_morphology1.20381636
50MP0002272_abnormal_nervous_system1.18128396
51MP0005174_abnormal_tail_pigmentation1.18122124
52MP0000026_abnormal_inner_ear1.16232939
53MP0000778_abnormal_nervous_system1.15563141
54MP0003252_abnormal_bile_duct1.14487097
55MP0003705_abnormal_hypodermis_morpholog1.13545429
56MP0009046_muscle_twitch1.11557934
57MP0005389_reproductive_system_phenotype1.11421211
58MP0000631_abnormal_neuroendocrine_gland1.11188494
59MP0005671_abnormal_response_to1.10577554
60MP0005075_abnormal_melanosome_morpholog1.09427578
61MP0001486_abnormal_startle_reflex1.08525774
62MP0003786_premature_aging1.06892443
63MP0000003_abnormal_adipose_tissue1.06789771
64MP0001919_abnormal_reproductive_system1.03145583
65MP0008877_abnormal_DNA_methylation1.03020446
66MP0005645_abnormal_hypothalamus_physiol1.02857915
67MP0003635_abnormal_synaptic_transmissio1.01944469
68MP0001764_abnormal_homeostasis1.00366370
69MP0002229_neurodegeneration0.99680085
70MP0004043_abnormal_pH_regulation0.95235385
71MP0002822_catalepsy0.93911647
72MP0002752_abnormal_somatic_nervous0.93456839
73MP0009765_abnormal_xenobiotic_induced0.90888224
74MP0009785_altered_susceptibility_to0.90505310
75MP0005085_abnormal_gallbladder_physiolo0.88799328
76MP0002733_abnormal_thermal_nociception0.88674138
77MP0000647_abnormal_sebaceous_gland0.88627475
78MP0002063_abnormal_learning/memory/cond0.88483130
79MP0000955_abnormal_spinal_cord0.87607184
80MP0002653_abnormal_ependyma_morphology0.87287190
81MP0003879_abnormal_hair_cell0.85944827
82MP0009333_abnormal_splenocyte_physiolog0.85567637
83MP0005195_abnormal_posterior_eye0.82423614
84MP0002067_abnormal_sensory_capabilities0.82405627
85MP0001963_abnormal_hearing_physiology0.82192255
86MP0002572_abnormal_emotion/affect_behav0.81635014
87MP0002909_abnormal_adrenal_gland0.81606965
88MP0002148_abnormal_hypersensitivity_rea0.80368150
89MP0004019_abnormal_vitamin_homeostasis0.79160433
90MP0001835_abnormal_antigen_presentation0.78662960
91MP0001970_abnormal_pain_threshold0.78540401
92MP0002069_abnormal_eating/drinking_beha0.78146919
93MP0002928_abnormal_bile_duct0.77654404
94MP0003121_genomic_imprinting0.77561271
95MP0001293_anophthalmia0.77184084
96MP0002210_abnormal_sex_determination0.75237408
97MP0004145_abnormal_muscle_electrophysio0.74881519
98MP0001853_heart_inflammation0.73519658
99MP0001944_abnormal_pancreas_morphology0.71546969
100MP0001324_abnormal_eye_pigmentation0.70257738

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of pyruvate family amino acid metabolism (HP:0010915)6.32640828
2Abnormality of alanine metabolism (HP:0010916)6.32640828
3Hyperalaninemia (HP:0003348)6.32640828
4Constricted visual fields (HP:0001133)5.27170045
5Decreased electroretinogram (ERG) amplitude (HP:0000654)3.90524440
6Congenital sensorineural hearing impairment (HP:0008527)3.77539307
7Abnormal respiratory motile cilium morphology (HP:0005938)3.69348831
8Abnormal respiratory epithelium morphology (HP:0012253)3.69348831
9Acute necrotizing encephalopathy (HP:0006965)3.29166449
10Reticulocytopenia (HP:0001896)3.28844370
11Homocystinuria (HP:0002156)3.24770056
12Abnormality of homocysteine metabolism (HP:0010919)3.24770056
13White forelock (HP:0002211)3.04076014
14Absent/shortened dynein arms (HP:0200106)3.01064660
15Dynein arm defect of respiratory motile cilia (HP:0012255)3.01064660
16Chronic hepatic failure (HP:0100626)3.01064645
17Patchy hypopigmentation of hair (HP:0011365)2.98117693
18Poor speech (HP:0002465)2.93704925
193-Methylglutaconic aciduria (HP:0003535)2.91575043
20Mitochondrial inheritance (HP:0001427)2.90130590
21Stenosis of the external auditory canal (HP:0000402)2.83276207
22Hepatocellular necrosis (HP:0001404)2.82988639
23Anorexia (HP:0002039)2.82906930
24Hypoplasia of the uterus (HP:0000013)2.77385307
25Chorioretinal atrophy (HP:0000533)2.76660712
26Abnormal mitochondria in muscle tissue (HP:0008316)2.74417319
27Acute encephalopathy (HP:0006846)2.72292103
28Progressive macrocephaly (HP:0004481)2.70446913
29Chronic otitis media (HP:0000389)2.67898351
30Recurrent gram-negative bacterial infections (HP:0005420)2.64983365
31Spontaneous hematomas (HP:0007420)2.57694258
32Action tremor (HP:0002345)2.55079061
33Molar tooth sign on MRI (HP:0002419)2.53482748
34Abnormality of midbrain morphology (HP:0002418)2.53482748
35Chronic sinusitis (HP:0011109)2.52990433
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.52243416
37Birth length less than 3rd percentile (HP:0003561)2.51176709
38Abnormality of serum amino acid levels (HP:0003112)2.50129978
39Increased CSF lactate (HP:0002490)2.48112473
40Esophageal varix (HP:0002040)2.45778920
41Aplasia/Hypoplasia of the sacrum (HP:0008517)2.43449361
42Optic nerve coloboma (HP:0000588)2.42340287
43Aplasia/hypoplasia of the uterus (HP:0008684)2.39464278
44Hyperphosphaturia (HP:0003109)2.37832546
45Generalized aminoaciduria (HP:0002909)2.36941664
46Hepatic necrosis (HP:0002605)2.35866600
47Recurrent abscess formation (HP:0002722)2.35673025
48Recurrent bacterial skin infections (HP:0005406)2.34428327
49Pancreatic fibrosis (HP:0100732)2.33862019
50Conjugated hyperbilirubinemia (HP:0002908)2.29796029
51Cerebral edema (HP:0002181)2.28825433
52Medial flaring of the eyebrow (HP:0010747)2.24648717
53Thrombocytosis (HP:0001894)2.22384658
54Supernumerary spleens (HP:0009799)2.19777502
55Spontaneous abortion (HP:0005268)2.08451642
56Abnormality of urine glucose concentration (HP:0011016)2.08249538
57Glycosuria (HP:0003076)2.08249538
58Proximal tubulopathy (HP:0000114)2.08173659
59Gait imbalance (HP:0002141)2.07801456
60Pulmonary embolism (HP:0002204)2.07474939
61Anencephaly (HP:0002323)2.07156605
62Myocardial infarction (HP:0001658)2.05346304
63Broad-based gait (HP:0002136)2.04686144
64Oligomenorrhea (HP:0000876)2.04545220
65Type 2 muscle fiber atrophy (HP:0003554)2.00990773
66Thrombophlebitis (HP:0004418)1.99169988
67True hermaphroditism (HP:0010459)1.97705894
68Abnormality of cells of the erythroid lineage (HP:0012130)1.97685030
69Nephrogenic diabetes insipidus (HP:0009806)1.97105250
70Abnormality of the corticospinal tract (HP:0002492)1.95341929
71Abnormality of sulfur amino acid metabolism (HP:0004339)1.94638307
72Elevated erythrocyte sedimentation rate (HP:0003565)1.94332094
73Thyroid-stimulating hormone excess (HP:0002925)1.93809471
74Pendular nystagmus (HP:0012043)1.92695942
75Metaphyseal dysplasia (HP:0100255)1.92650727
76Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.90084817
77Abnormal ciliary motility (HP:0012262)1.89416920
78Macrocytic anemia (HP:0001972)1.88954433
79Arterial thrombosis (HP:0004420)1.87622887
80Impaired vibration sensation in the lower limbs (HP:0002166)1.87353415
81Abolished electroretinogram (ERG) (HP:0000550)1.87176909
82Cortical visual impairment (HP:0100704)1.86862341
83Lactic acidosis (HP:0003128)1.86761520
84Tetany (HP:0001281)1.86104948
85Increased serum lactate (HP:0002151)1.84357155
86Pallor (HP:0000980)1.84208052
87Visual hallucinations (HP:0002367)1.84153527
88Pancreatic cysts (HP:0001737)1.84054100
89Abnormal umbilical cord blood vessels (HP:0011403)1.81705968
90Single umbilical artery (HP:0001195)1.81705968
91Abnormality of the fetal cardiovascular system (HP:0010948)1.81705968
92Abnormal respiratory motile cilium physiology (HP:0012261)1.80952387
93Agitation (HP:0000713)1.80033519
94Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.77390707
95Congenital stationary night blindness (HP:0007642)1.74594567
96Hypoalphalipoproteinemia (HP:0003233)1.73183033
97Conjunctival telangiectasia (HP:0000524)1.72325991
98Vaginal atresia (HP:0000148)1.72236868
99Nephronophthisis (HP:0000090)1.71329762
100Infertility (HP:0000789)1.70748630

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK23.70888262
2TLK13.68272652
3ACVR1B3.49858788
4EPHB23.07632226
5ZAK3.06465853
6GRK72.64848667
7NTRK32.53082884
8FRK2.30712446
9ADRBK22.22710014
10BCKDK2.15445284
11FGR1.97972834
12SGK2231.89440732
13SGK4941.89440732
14DYRK21.77693539
15MINK11.68278396
16CDC71.65713528
17PHKG11.64251767
18PHKG21.64251767
19VRK21.63957230
20MAP4K21.63549518
21CAMKK21.62501039
22ADRBK11.60916468
23MAP2K31.47896578
24TAOK31.46699093
25JAK31.45760613
26IRAK21.41617663
27MAP3K31.39450332
28CAMK11.31344561
29VRK11.31053521
30CDK91.30056291
31SGK21.26118512
32RPS6KB21.24406967
33EPHA41.24321415
34MARK11.23272879
35BMPR1B1.22552389
36TIE11.12295469
37TAF11.08623049
38STK161.00259583
39PINK10.99473824
40CAMK1D0.95840392
41PKN10.95212689
42TNIK0.93634701
43GRK10.89679345
44TXK0.86034385
45MAPK130.84640985
46PRKCI0.83922717
47CASK0.82467737
48KDR0.81922135
49CCNB10.78230923
50EIF2AK30.77573887
51CSNK1A10.77040671
52WNK30.74968184
53MKNK20.71411833
54PLK20.68307764
55CSNK1G20.67845247
56SGK30.66192509
57RPS6KA50.62538285
58PRKCG0.61795153
59CAMK1G0.61265737
60PRKCE0.60847886
61TEC0.59814496
62IKBKB0.59261161
63PIK3CA0.57449061
64CSK0.57056905
65CSF1R0.56981293
66LMTK20.56480156
67PIM20.56300883
68INSR0.54548059
69AKT30.54530618
70TRIM280.54244230
71PLK40.53597864
72CSNK1G30.53171001
73MAP4K10.53161160
74DYRK30.53009966
75CAMKK10.52709867
76SGK10.52703984
77CDK190.51714069
78CHEK20.49636753
79SYK0.49084865
80EGFR0.45414136
81PRKACA0.44966897
82BMX0.44951629
83NUAK10.43716065
84CSNK2A20.42655656
85PRKCQ0.42505004
86MST40.41312976
87BTK0.40722260
88LYN0.40405694
89EIF2AK20.40046096
90ITK0.39499894
91PRKCD0.38552924
92ABL20.36340230
93OXSR10.36046986
94PAK30.33827901
95CSNK1E0.32937275
96CDK50.32828161
97RPS6KA10.32158348
98LCK0.31521367
99NEK60.31308104
100PAK40.31238900

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.05937393
2Collecting duct acid secretion_Homo sapiens_hsa049663.20219785
3Ribosome_Homo sapiens_hsa030102.96327578
4Parkinsons disease_Homo sapiens_hsa050122.83771599
5Sulfur metabolism_Homo sapiens_hsa009202.81244823
6One carbon pool by folate_Homo sapiens_hsa006702.73851389
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.69516042
8Proteasome_Homo sapiens_hsa030502.38735271
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.22617002
10Huntingtons disease_Homo sapiens_hsa050162.18783484
11Basal transcription factors_Homo sapiens_hsa030222.16592050
12Arginine biosynthesis_Homo sapiens_hsa002202.12682299
13Alzheimers disease_Homo sapiens_hsa050102.11675308
14Protein export_Homo sapiens_hsa030602.10420779
15Rheumatoid arthritis_Homo sapiens_hsa053231.99042260
16Nicotine addiction_Homo sapiens_hsa050331.97486924
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.94967558
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.85398596
19Cardiac muscle contraction_Homo sapiens_hsa042601.72225259
20Regulation of autophagy_Homo sapiens_hsa041401.71008553
21Graft-versus-host disease_Homo sapiens_hsa053321.57184006
22GABAergic synapse_Homo sapiens_hsa047271.55522867
23Asthma_Homo sapiens_hsa053101.52460344
24Primary immunodeficiency_Homo sapiens_hsa053401.49634669
25Type I diabetes mellitus_Homo sapiens_hsa049401.48674680
26Morphine addiction_Homo sapiens_hsa050321.44199166
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.41325896
28Allograft rejection_Homo sapiens_hsa053301.34425913
29Systemic lupus erythematosus_Homo sapiens_hsa053221.30723438
30RNA degradation_Homo sapiens_hsa030181.28945565
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.25922710
32Alcoholism_Homo sapiens_hsa050341.23886879
33Peroxisome_Homo sapiens_hsa041461.22304747
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22080583
35Butanoate metabolism_Homo sapiens_hsa006501.18500068
36Nitrogen metabolism_Homo sapiens_hsa009101.17860099
37Synaptic vesicle cycle_Homo sapiens_hsa047211.17392128
38Homologous recombination_Homo sapiens_hsa034401.15650859
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14886966
40Autoimmune thyroid disease_Homo sapiens_hsa053201.12201233
41Retinol metabolism_Homo sapiens_hsa008301.12029133
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11519907
43Selenocompound metabolism_Homo sapiens_hsa004501.10216241
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09402671
45Propanoate metabolism_Homo sapiens_hsa006401.03722245
46Phototransduction_Homo sapiens_hsa047441.00934762
47RNA polymerase_Homo sapiens_hsa030201.00566864
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00508513
49Sulfur relay system_Homo sapiens_hsa041220.98341406
50Glutamatergic synapse_Homo sapiens_hsa047240.96906652
51Serotonergic synapse_Homo sapiens_hsa047260.96737154
52Spliceosome_Homo sapiens_hsa030400.95497559
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93459593
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.86666641
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84970979
56Circadian entrainment_Homo sapiens_hsa047130.80033558
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78196217
58Dopaminergic synapse_Homo sapiens_hsa047280.76898977
59Fatty acid biosynthesis_Homo sapiens_hsa000610.76729993
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76184217
61Vitamin digestion and absorption_Homo sapiens_hsa049770.74943357
62Hematopoietic cell lineage_Homo sapiens_hsa046400.73085348
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72336671
64Olfactory transduction_Homo sapiens_hsa047400.70206176
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69088160
66Ether lipid metabolism_Homo sapiens_hsa005650.68376440
67Antigen processing and presentation_Homo sapiens_hsa046120.65315863
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63500351
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59199984
70Cholinergic synapse_Homo sapiens_hsa047250.58172292
71Tryptophan metabolism_Homo sapiens_hsa003800.56853593
72Vibrio cholerae infection_Homo sapiens_hsa051100.56826323
73Metabolic pathways_Homo sapiens_hsa011000.53344678
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.53101345
75Taste transduction_Homo sapiens_hsa047420.52864878
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51907194
77Chemical carcinogenesis_Homo sapiens_hsa052040.51641556
78Phagosome_Homo sapiens_hsa041450.47883217
79RNA transport_Homo sapiens_hsa030130.47361152
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44959798
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.44006024
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43133250
83Fanconi anemia pathway_Homo sapiens_hsa034600.42147630
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41897987
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41005434
86Linoleic acid metabolism_Homo sapiens_hsa005910.39487178
87Mineral absorption_Homo sapiens_hsa049780.38594043
88Galactose metabolism_Homo sapiens_hsa000520.37631855
89ABC transporters_Homo sapiens_hsa020100.34983550
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33830269
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.33188887
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.32722965
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.32266124
94Base excision repair_Homo sapiens_hsa034100.29405064
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29214161
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28640347
97Purine metabolism_Homo sapiens_hsa002300.28440127
98mRNA surveillance pathway_Homo sapiens_hsa030150.27846780
99Insulin secretion_Homo sapiens_hsa049110.26077028
100Caffeine metabolism_Homo sapiens_hsa002320.25836388

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