

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 8.09646839 |
| 2 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 8.09646839 |
| 3 | homocysteine metabolic process (GO:0050667) | 6.27596012 |
| 4 | purine nucleotide salvage (GO:0032261) | 5.73497390 |
| 5 | ribosomal small subunit assembly (GO:0000028) | 5.69570203 |
| 6 | sulfur amino acid catabolic process (GO:0000098) | 5.36233945 |
| 7 | regulation of plasminogen activation (GO:0010755) | 5.27678789 |
| 8 | folic acid-containing compound biosynthetic process (GO:0009396) | 5.04226338 |
| 9 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.92698016 |
| 10 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.92698016 |
| 11 | NADH dehydrogenase complex assembly (GO:0010257) | 4.92698016 |
| 12 | maturation of SSU-rRNA (GO:0030490) | 4.91030361 |
| 13 | adenosine metabolic process (GO:0046085) | 4.84404897 |
| 14 | negative regulation of DNA biosynthetic process (GO:2000279) | 4.57580229 |
| 15 | protein complex biogenesis (GO:0070271) | 4.48317993 |
| 16 | white fat cell differentiation (GO:0050872) | 4.46358679 |
| 17 | epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198) | 4.40639821 |
| 18 | cysteine metabolic process (GO:0006534) | 4.37327851 |
| 19 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 4.25281337 |
| 20 | tachykinin receptor signaling pathway (GO:0007217) | 4.21745643 |
| 21 | behavioral response to nicotine (GO:0035095) | 4.20039874 |
| 22 | negative regulation of catenin import into nucleus (GO:0035414) | 4.17630934 |
| 23 | microtubule nucleation (GO:0007020) | 4.16939621 |
| 24 | protein-cofactor linkage (GO:0018065) | 4.01397266 |
| 25 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.90082661 |
| 26 | mitochondrial RNA metabolic process (GO:0000959) | 3.77890322 |
| 27 | cochlea development (GO:0090102) | 3.74643627 |
| 28 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.70810726 |
| 29 | negative regulation of Ras GTPase activity (GO:0034261) | 3.70557872 |
| 30 | negative regulation of keratinocyte proliferation (GO:0010839) | 3.59005662 |
| 31 | pteridine-containing compound biosynthetic process (GO:0042559) | 3.58730824 |
| 32 | cilium or flagellum-dependent cell motility (GO:0001539) | 3.56709710 |
| 33 | regulation of gonadotropin secretion (GO:0032276) | 3.53381127 |
| 34 | protein localization to vacuole (GO:0072665) | 3.52629416 |
| 35 | protein localization to lysosome (GO:0061462) | 3.52629416 |
| 36 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 3.51099388 |
| 37 | regulation of response to food (GO:0032095) | 3.48723413 |
| 38 | protein targeting to lysosome (GO:0006622) | 3.45215886 |
| 39 | establishment of protein localization to vacuole (GO:0072666) | 3.45215886 |
| 40 | protein targeting to vacuole (GO:0006623) | 3.45215886 |
| 41 | alternative mRNA splicing, via spliceosome (GO:0000380) | 3.40788397 |
| 42 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.40631824 |
| 43 | negative regulation of response to food (GO:0032096) | 3.37136936 |
| 44 | negative regulation of appetite (GO:0032099) | 3.37136936 |
| 45 | galactose metabolic process (GO:0006012) | 3.36776467 |
| 46 | chaperone-mediated protein transport (GO:0072321) | 3.34871537 |
| 47 | axonemal dynein complex assembly (GO:0070286) | 3.34664086 |
| 48 | neurofilament cytoskeleton organization (GO:0060052) | 3.34473106 |
| 49 | behavioral fear response (GO:0001662) | 3.30851567 |
| 50 | behavioral defense response (GO:0002209) | 3.30851567 |
| 51 | ribosome biogenesis (GO:0042254) | 3.29983560 |
| 52 | positive regulation of interleukin-17 production (GO:0032740) | 3.29293184 |
| 53 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO | 3.27690356 |
| 54 | negative regulation of response to extracellular stimulus (GO:0032105) | 3.26952873 |
| 55 | negative regulation of response to nutrient levels (GO:0032108) | 3.26952873 |
| 56 | purine-containing compound salvage (GO:0043101) | 3.25714166 |
| 57 | inner ear receptor cell development (GO:0060119) | 3.23455317 |
| 58 | inner mitochondrial membrane organization (GO:0007007) | 3.17601054 |
| 59 | establishment of mitochondrion localization (GO:0051654) | 3.16819016 |
| 60 | nucleotide salvage (GO:0043173) | 3.15739972 |
| 61 | regulation of vitamin D biosynthetic process (GO:0060556) | 3.15500410 |
| 62 | cellular component biogenesis (GO:0044085) | 3.13118590 |
| 63 | positive regulation of endothelial cell differentiation (GO:0045603) | 3.12625249 |
| 64 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 3.09520659 |
| 65 | single strand break repair (GO:0000012) | 3.07625104 |
| 66 | negative regulation of heart rate (GO:0010459) | 3.06927536 |
| 67 | histone H4-K12 acetylation (GO:0043983) | 3.05520137 |
| 68 | regulation of sequestering of triglyceride (GO:0010889) | 3.03265320 |
| 69 | negative regulation of telomerase activity (GO:0051974) | 3.01713156 |
| 70 | rRNA methylation (GO:0031167) | 3.00196102 |
| 71 | IMP biosynthetic process (GO:0006188) | 2.98121931 |
| 72 | pyrimidine nucleotide catabolic process (GO:0006244) | 2.97144290 |
| 73 | positive regulation of oligodendrocyte differentiation (GO:0048714) | 2.96852842 |
| 74 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 2.94826566 |
| 75 | substrate-independent telencephalic tangential migration (GO:0021826) | 2.93265852 |
| 76 | substrate-independent telencephalic tangential interneuron migration (GO:0021843) | 2.93265852 |
| 77 | regulation of appetite (GO:0032098) | 2.91793198 |
| 78 | primary amino compound metabolic process (GO:1901160) | 2.91767037 |
| 79 | tRNA processing (GO:0008033) | 2.87182196 |
| 80 | protein-chromophore linkage (GO:0018298) | 2.86260164 |
| 81 | CENP-A containing nucleosome assembly (GO:0034080) | 2.86252400 |
| 82 | regulation of cilium movement (GO:0003352) | 2.85725141 |
| 83 | respiratory electron transport chain (GO:0022904) | 2.84596130 |
| 84 | rRNA modification (GO:0000154) | 2.83797374 |
| 85 | innervation (GO:0060384) | 2.83295085 |
| 86 | fear response (GO:0042596) | 2.81477996 |
| 87 | electron transport chain (GO:0022900) | 2.80893299 |
| 88 | ribonucleoprotein complex biogenesis (GO:0022613) | 2.78650172 |
| 89 | superoxide anion generation (GO:0042554) | 2.76181860 |
| 90 | estrogen biosynthetic process (GO:0006703) | 2.74585447 |
| 91 | hydrogen peroxide biosynthetic process (GO:0050665) | 2.72733329 |
| 92 | L-serine metabolic process (GO:0006563) | 2.72317825 |
| 93 | positive regulation of respiratory burst (GO:0060267) | 2.72212754 |
| 94 | regulation of telomerase activity (GO:0051972) | 2.70639990 |
| 95 | respiratory chain complex IV assembly (GO:0008535) | 2.69125612 |
| 96 | polyamine biosynthetic process (GO:0006596) | 2.67266157 |
| 97 | IMP metabolic process (GO:0046040) | 2.66404913 |
| 98 | cytochrome complex assembly (GO:0017004) | 2.65207386 |
| 99 | chromatin remodeling at centromere (GO:0031055) | 2.65151297 |
| 100 | regulation of isotype switching to IgG isotypes (GO:0048302) | 2.63289902 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 9.08252929 |
| 2 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 6.22161289 |
| 3 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.88110174 |
| 4 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.77159658 |
| 5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.65722818 |
| 6 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.83676909 |
| 7 | VDR_22108803_ChIP-Seq_LS180_Human | 2.80074772 |
| 8 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.70467825 |
| 9 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.48070093 |
| 10 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.39707181 |
| 11 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.21909568 |
| 12 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.94590843 |
| 13 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.93564381 |
| 14 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.87562600 |
| 15 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.76971314 |
| 16 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.73289030 |
| 17 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.63426353 |
| 18 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.62698515 |
| 19 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.62427647 |
| 20 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.60336248 |
| 21 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.55977531 |
| 22 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.43939498 |
| 23 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.43805057 |
| 24 | NCOR_22424771_ChIP-Seq_293T_Human | 1.42173020 |
| 25 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.42093715 |
| 26 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.41555850 |
| 27 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.39547025 |
| 28 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.39378300 |
| 29 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.38995231 |
| 30 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.37399203 |
| 31 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 1.35190488 |
| 32 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.34390725 |
| 33 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.34355341 |
| 34 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.32155873 |
| 35 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.31722156 |
| 36 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.30421305 |
| 37 | STAT1_20625510_ChIP-Seq_HELA_Human | 1.26823990 |
| 38 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.25369056 |
| 39 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.22925911 |
| 40 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.20073358 |
| 41 | P300_19829295_ChIP-Seq_ESCs_Human | 1.19263982 |
| 42 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.18553044 |
| 43 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.16522767 |
| 44 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.15902625 |
| 45 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.15623882 |
| 46 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.14476660 |
| 47 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.14446871 |
| 48 | FUS_26573619_Chip-Seq_HEK293_Human | 1.12319917 |
| 49 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.11464843 |
| 50 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.11036154 |
| 51 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.10173701 |
| 52 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.09967663 |
| 53 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.09275401 |
| 54 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.07191496 |
| 55 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.05754749 |
| 56 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.03336739 |
| 57 | CDX2_22108803_ChIP-Seq_LS180_Human | 1.01911751 |
| 58 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.01349574 |
| 59 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 1.01229501 |
| 60 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.00735074 |
| 61 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.00735074 |
| 62 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.00667983 |
| 63 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.99937718 |
| 64 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.99937718 |
| 65 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.98937135 |
| 66 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.98651134 |
| 67 | GABP_19822575_ChIP-Seq_HepG2_Human | 0.98441669 |
| 68 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.97581189 |
| 69 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.97322514 |
| 70 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.95792786 |
| 71 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.94293591 |
| 72 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.93425528 |
| 73 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.93203972 |
| 74 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.93010056 |
| 75 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.92860640 |
| 76 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.90593012 |
| 77 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.89807174 |
| 78 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.89442515 |
| 79 | EWS_26573619_Chip-Seq_HEK293_Human | 0.89255066 |
| 80 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.87987035 |
| 81 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.87749665 |
| 82 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.87732519 |
| 83 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.87477417 |
| 84 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.86483241 |
| 85 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.86483241 |
| 86 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.85970704 |
| 87 | GATA3_21867929_ChIP-Seq_TH1_Mouse | 0.85915126 |
| 88 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.85827753 |
| 89 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 0.85775572 |
| 90 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 0.84141084 |
| 91 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.84052141 |
| 92 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.83915659 |
| 93 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.83591868 |
| 94 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.83437059 |
| 95 | OCT1_27270436_Chip-Seq_PROSTATE_Human | 0.82676822 |
| 96 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.81811079 |
| 97 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 0.80944951 |
| 98 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.79113572 |
| 99 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.78975083 |
| 100 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.78335640 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0009379_abnormal_foot_pigmentation | 4.11174690 |
| 2 | MP0003787_abnormal_imprinting | 3.43590756 |
| 3 | MP0000013_abnormal_adipose_tissue | 3.43572343 |
| 4 | MP0004885_abnormal_endolymph | 2.74403981 |
| 5 | MP0005670_abnormal_white_adipose | 2.64126243 |
| 6 | MP0008995_early_reproductive_senescence | 2.57432502 |
| 7 | MP0002938_white_spotting | 2.56678365 |
| 8 | MP0005360_urolithiasis | 2.49099398 |
| 9 | MP0002735_abnormal_chemical_nociception | 2.44240552 |
| 10 | MP0003880_abnormal_central_pattern | 2.39011834 |
| 11 | MP0005646_abnormal_pituitary_gland | 2.32717727 |
| 12 | MP0005367_renal/urinary_system_phenotyp | 2.28068399 |
| 13 | MP0000516_abnormal_urinary_system | 2.28068399 |
| 14 | MP0002736_abnormal_nociception_after | 2.26180628 |
| 15 | MP0003806_abnormal_nucleotide_metabolis | 2.22278574 |
| 16 | MP0001968_abnormal_touch/_nociception | 2.10593370 |
| 17 | MP0001661_extended_life_span | 2.04997820 |
| 18 | MP0006072_abnormal_retinal_apoptosis | 1.99456991 |
| 19 | MP0001440_abnormal_grooming_behavior | 1.91274462 |
| 20 | MP0002095_abnormal_skin_pigmentation | 1.88076583 |
| 21 | MP0004147_increased_porphyrin_level | 1.87506931 |
| 22 | MP0006292_abnormal_olfactory_placode | 1.78904203 |
| 23 | MP0002876_abnormal_thyroid_physiology | 1.72460616 |
| 24 | MP0004133_heterotaxia | 1.65138112 |
| 25 | MP0005551_abnormal_eye_electrophysiolog | 1.64316318 |
| 26 | MP0001502_abnormal_circadian_rhythm | 1.61381376 |
| 27 | MP0005332_abnormal_amino_acid | 1.60741653 |
| 28 | MP0005253_abnormal_eye_physiology | 1.59496351 |
| 29 | MP0003724_increased_susceptibility_to | 1.54335442 |
| 30 | MP0006276_abnormal_autonomic_nervous | 1.54027665 |
| 31 | MP0008872_abnormal_physiological_respon | 1.52966439 |
| 32 | MP0003011_delayed_dark_adaptation | 1.48374567 |
| 33 | MP0008789_abnormal_olfactory_epithelium | 1.46494054 |
| 34 | MP0004142_abnormal_muscle_tone | 1.45907524 |
| 35 | MP0001905_abnormal_dopamine_level | 1.45537044 |
| 36 | MP0009053_abnormal_anal_canal | 1.41327951 |
| 37 | MP0003183_abnormal_peptide_metabolism | 1.40326413 |
| 38 | MP0003890_abnormal_embryonic-extraembry | 1.38453882 |
| 39 | MP0000569_abnormal_digit_pigmentation | 1.36749433 |
| 40 | MP0002184_abnormal_innervation | 1.36396150 |
| 41 | MP0002160_abnormal_reproductive_system | 1.34768278 |
| 42 | MP0003186_abnormal_redox_activity | 1.34260236 |
| 43 | MP0001756_abnormal_urination | 1.33102300 |
| 44 | MP0002837_dystrophic_cardiac_calcinosis | 1.26356138 |
| 45 | MP0009745_abnormal_behavioral_response | 1.26301366 |
| 46 | MP0005499_abnormal_olfactory_system | 1.24215247 |
| 47 | MP0005394_taste/olfaction_phenotype | 1.24215247 |
| 48 | MP0003123_paternal_imprinting | 1.22230609 |
| 49 | MP0000534_abnormal_ureter_morphology | 1.20381636 |
| 50 | MP0002272_abnormal_nervous_system | 1.18128396 |
| 51 | MP0005174_abnormal_tail_pigmentation | 1.18122124 |
| 52 | MP0000026_abnormal_inner_ear | 1.16232939 |
| 53 | MP0000778_abnormal_nervous_system | 1.15563141 |
| 54 | MP0003252_abnormal_bile_duct | 1.14487097 |
| 55 | MP0003705_abnormal_hypodermis_morpholog | 1.13545429 |
| 56 | MP0009046_muscle_twitch | 1.11557934 |
| 57 | MP0005389_reproductive_system_phenotype | 1.11421211 |
| 58 | MP0000631_abnormal_neuroendocrine_gland | 1.11188494 |
| 59 | MP0005671_abnormal_response_to | 1.10577554 |
| 60 | MP0005075_abnormal_melanosome_morpholog | 1.09427578 |
| 61 | MP0001486_abnormal_startle_reflex | 1.08525774 |
| 62 | MP0003786_premature_aging | 1.06892443 |
| 63 | MP0000003_abnormal_adipose_tissue | 1.06789771 |
| 64 | MP0001919_abnormal_reproductive_system | 1.03145583 |
| 65 | MP0008877_abnormal_DNA_methylation | 1.03020446 |
| 66 | MP0005645_abnormal_hypothalamus_physiol | 1.02857915 |
| 67 | MP0003635_abnormal_synaptic_transmissio | 1.01944469 |
| 68 | MP0001764_abnormal_homeostasis | 1.00366370 |
| 69 | MP0002229_neurodegeneration | 0.99680085 |
| 70 | MP0004043_abnormal_pH_regulation | 0.95235385 |
| 71 | MP0002822_catalepsy | 0.93911647 |
| 72 | MP0002752_abnormal_somatic_nervous | 0.93456839 |
| 73 | MP0009765_abnormal_xenobiotic_induced | 0.90888224 |
| 74 | MP0009785_altered_susceptibility_to | 0.90505310 |
| 75 | MP0005085_abnormal_gallbladder_physiolo | 0.88799328 |
| 76 | MP0002733_abnormal_thermal_nociception | 0.88674138 |
| 77 | MP0000647_abnormal_sebaceous_gland | 0.88627475 |
| 78 | MP0002063_abnormal_learning/memory/cond | 0.88483130 |
| 79 | MP0000955_abnormal_spinal_cord | 0.87607184 |
| 80 | MP0002653_abnormal_ependyma_morphology | 0.87287190 |
| 81 | MP0003879_abnormal_hair_cell | 0.85944827 |
| 82 | MP0009333_abnormal_splenocyte_physiolog | 0.85567637 |
| 83 | MP0005195_abnormal_posterior_eye | 0.82423614 |
| 84 | MP0002067_abnormal_sensory_capabilities | 0.82405627 |
| 85 | MP0001963_abnormal_hearing_physiology | 0.82192255 |
| 86 | MP0002572_abnormal_emotion/affect_behav | 0.81635014 |
| 87 | MP0002909_abnormal_adrenal_gland | 0.81606965 |
| 88 | MP0002148_abnormal_hypersensitivity_rea | 0.80368150 |
| 89 | MP0004019_abnormal_vitamin_homeostasis | 0.79160433 |
| 90 | MP0001835_abnormal_antigen_presentation | 0.78662960 |
| 91 | MP0001970_abnormal_pain_threshold | 0.78540401 |
| 92 | MP0002069_abnormal_eating/drinking_beha | 0.78146919 |
| 93 | MP0002928_abnormal_bile_duct | 0.77654404 |
| 94 | MP0003121_genomic_imprinting | 0.77561271 |
| 95 | MP0001293_anophthalmia | 0.77184084 |
| 96 | MP0002210_abnormal_sex_determination | 0.75237408 |
| 97 | MP0004145_abnormal_muscle_electrophysio | 0.74881519 |
| 98 | MP0001853_heart_inflammation | 0.73519658 |
| 99 | MP0001944_abnormal_pancreas_morphology | 0.71546969 |
| 100 | MP0001324_abnormal_eye_pigmentation | 0.70257738 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 6.32640828 |
| 2 | Abnormality of alanine metabolism (HP:0010916) | 6.32640828 |
| 3 | Hyperalaninemia (HP:0003348) | 6.32640828 |
| 4 | Constricted visual fields (HP:0001133) | 5.27170045 |
| 5 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 3.90524440 |
| 6 | Congenital sensorineural hearing impairment (HP:0008527) | 3.77539307 |
| 7 | Abnormal respiratory motile cilium morphology (HP:0005938) | 3.69348831 |
| 8 | Abnormal respiratory epithelium morphology (HP:0012253) | 3.69348831 |
| 9 | Acute necrotizing encephalopathy (HP:0006965) | 3.29166449 |
| 10 | Reticulocytopenia (HP:0001896) | 3.28844370 |
| 11 | Homocystinuria (HP:0002156) | 3.24770056 |
| 12 | Abnormality of homocysteine metabolism (HP:0010919) | 3.24770056 |
| 13 | White forelock (HP:0002211) | 3.04076014 |
| 14 | Absent/shortened dynein arms (HP:0200106) | 3.01064660 |
| 15 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 3.01064660 |
| 16 | Chronic hepatic failure (HP:0100626) | 3.01064645 |
| 17 | Patchy hypopigmentation of hair (HP:0011365) | 2.98117693 |
| 18 | Poor speech (HP:0002465) | 2.93704925 |
| 19 | 3-Methylglutaconic aciduria (HP:0003535) | 2.91575043 |
| 20 | Mitochondrial inheritance (HP:0001427) | 2.90130590 |
| 21 | Stenosis of the external auditory canal (HP:0000402) | 2.83276207 |
| 22 | Hepatocellular necrosis (HP:0001404) | 2.82988639 |
| 23 | Anorexia (HP:0002039) | 2.82906930 |
| 24 | Hypoplasia of the uterus (HP:0000013) | 2.77385307 |
| 25 | Chorioretinal atrophy (HP:0000533) | 2.76660712 |
| 26 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.74417319 |
| 27 | Acute encephalopathy (HP:0006846) | 2.72292103 |
| 28 | Progressive macrocephaly (HP:0004481) | 2.70446913 |
| 29 | Chronic otitis media (HP:0000389) | 2.67898351 |
| 30 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.64983365 |
| 31 | Spontaneous hematomas (HP:0007420) | 2.57694258 |
| 32 | Action tremor (HP:0002345) | 2.55079061 |
| 33 | Molar tooth sign on MRI (HP:0002419) | 2.53482748 |
| 34 | Abnormality of midbrain morphology (HP:0002418) | 2.53482748 |
| 35 | Chronic sinusitis (HP:0011109) | 2.52990433 |
| 36 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.52243416 |
| 37 | Birth length less than 3rd percentile (HP:0003561) | 2.51176709 |
| 38 | Abnormality of serum amino acid levels (HP:0003112) | 2.50129978 |
| 39 | Increased CSF lactate (HP:0002490) | 2.48112473 |
| 40 | Esophageal varix (HP:0002040) | 2.45778920 |
| 41 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.43449361 |
| 42 | Optic nerve coloboma (HP:0000588) | 2.42340287 |
| 43 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.39464278 |
| 44 | Hyperphosphaturia (HP:0003109) | 2.37832546 |
| 45 | Generalized aminoaciduria (HP:0002909) | 2.36941664 |
| 46 | Hepatic necrosis (HP:0002605) | 2.35866600 |
| 47 | Recurrent abscess formation (HP:0002722) | 2.35673025 |
| 48 | Recurrent bacterial skin infections (HP:0005406) | 2.34428327 |
| 49 | Pancreatic fibrosis (HP:0100732) | 2.33862019 |
| 50 | Conjugated hyperbilirubinemia (HP:0002908) | 2.29796029 |
| 51 | Cerebral edema (HP:0002181) | 2.28825433 |
| 52 | Medial flaring of the eyebrow (HP:0010747) | 2.24648717 |
| 53 | Thrombocytosis (HP:0001894) | 2.22384658 |
| 54 | Supernumerary spleens (HP:0009799) | 2.19777502 |
| 55 | Spontaneous abortion (HP:0005268) | 2.08451642 |
| 56 | Abnormality of urine glucose concentration (HP:0011016) | 2.08249538 |
| 57 | Glycosuria (HP:0003076) | 2.08249538 |
| 58 | Proximal tubulopathy (HP:0000114) | 2.08173659 |
| 59 | Gait imbalance (HP:0002141) | 2.07801456 |
| 60 | Pulmonary embolism (HP:0002204) | 2.07474939 |
| 61 | Anencephaly (HP:0002323) | 2.07156605 |
| 62 | Myocardial infarction (HP:0001658) | 2.05346304 |
| 63 | Broad-based gait (HP:0002136) | 2.04686144 |
| 64 | Oligomenorrhea (HP:0000876) | 2.04545220 |
| 65 | Type 2 muscle fiber atrophy (HP:0003554) | 2.00990773 |
| 66 | Thrombophlebitis (HP:0004418) | 1.99169988 |
| 67 | True hermaphroditism (HP:0010459) | 1.97705894 |
| 68 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.97685030 |
| 69 | Nephrogenic diabetes insipidus (HP:0009806) | 1.97105250 |
| 70 | Abnormality of the corticospinal tract (HP:0002492) | 1.95341929 |
| 71 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 1.94638307 |
| 72 | Elevated erythrocyte sedimentation rate (HP:0003565) | 1.94332094 |
| 73 | Thyroid-stimulating hormone excess (HP:0002925) | 1.93809471 |
| 74 | Pendular nystagmus (HP:0012043) | 1.92695942 |
| 75 | Metaphyseal dysplasia (HP:0100255) | 1.92650727 |
| 76 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.90084817 |
| 77 | Abnormal ciliary motility (HP:0012262) | 1.89416920 |
| 78 | Macrocytic anemia (HP:0001972) | 1.88954433 |
| 79 | Arterial thrombosis (HP:0004420) | 1.87622887 |
| 80 | Impaired vibration sensation in the lower limbs (HP:0002166) | 1.87353415 |
| 81 | Abolished electroretinogram (ERG) (HP:0000550) | 1.87176909 |
| 82 | Cortical visual impairment (HP:0100704) | 1.86862341 |
| 83 | Lactic acidosis (HP:0003128) | 1.86761520 |
| 84 | Tetany (HP:0001281) | 1.86104948 |
| 85 | Increased serum lactate (HP:0002151) | 1.84357155 |
| 86 | Pallor (HP:0000980) | 1.84208052 |
| 87 | Visual hallucinations (HP:0002367) | 1.84153527 |
| 88 | Pancreatic cysts (HP:0001737) | 1.84054100 |
| 89 | Abnormal umbilical cord blood vessels (HP:0011403) | 1.81705968 |
| 90 | Single umbilical artery (HP:0001195) | 1.81705968 |
| 91 | Abnormality of the fetal cardiovascular system (HP:0010948) | 1.81705968 |
| 92 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.80952387 |
| 93 | Agitation (HP:0000713) | 1.80033519 |
| 94 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 1.77390707 |
| 95 | Congenital stationary night blindness (HP:0007642) | 1.74594567 |
| 96 | Hypoalphalipoproteinemia (HP:0003233) | 1.73183033 |
| 97 | Conjunctival telangiectasia (HP:0000524) | 1.72325991 |
| 98 | Vaginal atresia (HP:0000148) | 1.72236868 |
| 99 | Nephronophthisis (HP:0000090) | 1.71329762 |
| 100 | Infertility (HP:0000789) | 1.70748630 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NTRK2 | 3.70888262 |
| 2 | TLK1 | 3.68272652 |
| 3 | ACVR1B | 3.49858788 |
| 4 | EPHB2 | 3.07632226 |
| 5 | ZAK | 3.06465853 |
| 6 | GRK7 | 2.64848667 |
| 7 | NTRK3 | 2.53082884 |
| 8 | FRK | 2.30712446 |
| 9 | ADRBK2 | 2.22710014 |
| 10 | BCKDK | 2.15445284 |
| 11 | FGR | 1.97972834 |
| 12 | SGK223 | 1.89440732 |
| 13 | SGK494 | 1.89440732 |
| 14 | DYRK2 | 1.77693539 |
| 15 | MINK1 | 1.68278396 |
| 16 | CDC7 | 1.65713528 |
| 17 | PHKG1 | 1.64251767 |
| 18 | PHKG2 | 1.64251767 |
| 19 | VRK2 | 1.63957230 |
| 20 | MAP4K2 | 1.63549518 |
| 21 | CAMKK2 | 1.62501039 |
| 22 | ADRBK1 | 1.60916468 |
| 23 | MAP2K3 | 1.47896578 |
| 24 | TAOK3 | 1.46699093 |
| 25 | JAK3 | 1.45760613 |
| 26 | IRAK2 | 1.41617663 |
| 27 | MAP3K3 | 1.39450332 |
| 28 | CAMK1 | 1.31344561 |
| 29 | VRK1 | 1.31053521 |
| 30 | CDK9 | 1.30056291 |
| 31 | SGK2 | 1.26118512 |
| 32 | RPS6KB2 | 1.24406967 |
| 33 | EPHA4 | 1.24321415 |
| 34 | MARK1 | 1.23272879 |
| 35 | BMPR1B | 1.22552389 |
| 36 | TIE1 | 1.12295469 |
| 37 | TAF1 | 1.08623049 |
| 38 | STK16 | 1.00259583 |
| 39 | PINK1 | 0.99473824 |
| 40 | CAMK1D | 0.95840392 |
| 41 | PKN1 | 0.95212689 |
| 42 | TNIK | 0.93634701 |
| 43 | GRK1 | 0.89679345 |
| 44 | TXK | 0.86034385 |
| 45 | MAPK13 | 0.84640985 |
| 46 | PRKCI | 0.83922717 |
| 47 | CASK | 0.82467737 |
| 48 | KDR | 0.81922135 |
| 49 | CCNB1 | 0.78230923 |
| 50 | EIF2AK3 | 0.77573887 |
| 51 | CSNK1A1 | 0.77040671 |
| 52 | WNK3 | 0.74968184 |
| 53 | MKNK2 | 0.71411833 |
| 54 | PLK2 | 0.68307764 |
| 55 | CSNK1G2 | 0.67845247 |
| 56 | SGK3 | 0.66192509 |
| 57 | RPS6KA5 | 0.62538285 |
| 58 | PRKCG | 0.61795153 |
| 59 | CAMK1G | 0.61265737 |
| 60 | PRKCE | 0.60847886 |
| 61 | TEC | 0.59814496 |
| 62 | IKBKB | 0.59261161 |
| 63 | PIK3CA | 0.57449061 |
| 64 | CSK | 0.57056905 |
| 65 | CSF1R | 0.56981293 |
| 66 | LMTK2 | 0.56480156 |
| 67 | PIM2 | 0.56300883 |
| 68 | INSR | 0.54548059 |
| 69 | AKT3 | 0.54530618 |
| 70 | TRIM28 | 0.54244230 |
| 71 | PLK4 | 0.53597864 |
| 72 | CSNK1G3 | 0.53171001 |
| 73 | MAP4K1 | 0.53161160 |
| 74 | DYRK3 | 0.53009966 |
| 75 | CAMKK1 | 0.52709867 |
| 76 | SGK1 | 0.52703984 |
| 77 | CDK19 | 0.51714069 |
| 78 | CHEK2 | 0.49636753 |
| 79 | SYK | 0.49084865 |
| 80 | EGFR | 0.45414136 |
| 81 | PRKACA | 0.44966897 |
| 82 | BMX | 0.44951629 |
| 83 | NUAK1 | 0.43716065 |
| 84 | CSNK2A2 | 0.42655656 |
| 85 | PRKCQ | 0.42505004 |
| 86 | MST4 | 0.41312976 |
| 87 | BTK | 0.40722260 |
| 88 | LYN | 0.40405694 |
| 89 | EIF2AK2 | 0.40046096 |
| 90 | ITK | 0.39499894 |
| 91 | PRKCD | 0.38552924 |
| 92 | ABL2 | 0.36340230 |
| 93 | OXSR1 | 0.36046986 |
| 94 | PAK3 | 0.33827901 |
| 95 | CSNK1E | 0.32937275 |
| 96 | CDK5 | 0.32828161 |
| 97 | RPS6KA1 | 0.32158348 |
| 98 | LCK | 0.31521367 |
| 99 | NEK6 | 0.31308104 |
| 100 | PAK4 | 0.31238900 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.05937393 |
| 2 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 3.20219785 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 2.96327578 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 2.83771599 |
| 5 | Sulfur metabolism_Homo sapiens_hsa00920 | 2.81244823 |
| 6 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.73851389 |
| 7 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 2.69516042 |
| 8 | Proteasome_Homo sapiens_hsa03050 | 2.38735271 |
| 9 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.22617002 |
| 10 | Huntingtons disease_Homo sapiens_hsa05016 | 2.18783484 |
| 11 | Basal transcription factors_Homo sapiens_hsa03022 | 2.16592050 |
| 12 | Arginine biosynthesis_Homo sapiens_hsa00220 | 2.12682299 |
| 13 | Alzheimers disease_Homo sapiens_hsa05010 | 2.11675308 |
| 14 | Protein export_Homo sapiens_hsa03060 | 2.10420779 |
| 15 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.99042260 |
| 16 | Nicotine addiction_Homo sapiens_hsa05033 | 1.97486924 |
| 17 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.94967558 |
| 18 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.85398596 |
| 19 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.72225259 |
| 20 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.71008553 |
| 21 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.57184006 |
| 22 | GABAergic synapse_Homo sapiens_hsa04727 | 1.55522867 |
| 23 | Asthma_Homo sapiens_hsa05310 | 1.52460344 |
| 24 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.49634669 |
| 25 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.48674680 |
| 26 | Morphine addiction_Homo sapiens_hsa05032 | 1.44199166 |
| 27 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.41325896 |
| 28 | Allograft rejection_Homo sapiens_hsa05330 | 1.34425913 |
| 29 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.30723438 |
| 30 | RNA degradation_Homo sapiens_hsa03018 | 1.28945565 |
| 31 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.25922710 |
| 32 | Alcoholism_Homo sapiens_hsa05034 | 1.23886879 |
| 33 | Peroxisome_Homo sapiens_hsa04146 | 1.22304747 |
| 34 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.22080583 |
| 35 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.18500068 |
| 36 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.17860099 |
| 37 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.17392128 |
| 38 | Homologous recombination_Homo sapiens_hsa03440 | 1.15650859 |
| 39 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.14886966 |
| 40 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.12201233 |
| 41 | Retinol metabolism_Homo sapiens_hsa00830 | 1.12029133 |
| 42 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.11519907 |
| 43 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.10216241 |
| 44 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.09402671 |
| 45 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.03722245 |
| 46 | Phototransduction_Homo sapiens_hsa04744 | 1.00934762 |
| 47 | RNA polymerase_Homo sapiens_hsa03020 | 1.00566864 |
| 48 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.00508513 |
| 49 | Sulfur relay system_Homo sapiens_hsa04122 | 0.98341406 |
| 50 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.96906652 |
| 51 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.96737154 |
| 52 | Spliceosome_Homo sapiens_hsa03040 | 0.95497559 |
| 53 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.93459593 |
| 54 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.86666641 |
| 55 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.84970979 |
| 56 | Circadian entrainment_Homo sapiens_hsa04713 | 0.80033558 |
| 57 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.78196217 |
| 58 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.76898977 |
| 59 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.76729993 |
| 60 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.76184217 |
| 61 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.74943357 |
| 62 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.73085348 |
| 63 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.72336671 |
| 64 | Olfactory transduction_Homo sapiens_hsa04740 | 0.70206176 |
| 65 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.69088160 |
| 66 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.68376440 |
| 67 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.65315863 |
| 68 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.63500351 |
| 69 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.59199984 |
| 70 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.58172292 |
| 71 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.56853593 |
| 72 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.56826323 |
| 73 | Metabolic pathways_Homo sapiens_hsa01100 | 0.53344678 |
| 74 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.53101345 |
| 75 | Taste transduction_Homo sapiens_hsa04742 | 0.52864878 |
| 76 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.51907194 |
| 77 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.51641556 |
| 78 | Phagosome_Homo sapiens_hsa04145 | 0.47883217 |
| 79 | RNA transport_Homo sapiens_hsa03013 | 0.47361152 |
| 80 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.44959798 |
| 81 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.44006024 |
| 82 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.43133250 |
| 83 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.42147630 |
| 84 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.41897987 |
| 85 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.41005434 |
| 86 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.39487178 |
| 87 | Mineral absorption_Homo sapiens_hsa04978 | 0.38594043 |
| 88 | Galactose metabolism_Homo sapiens_hsa00052 | 0.37631855 |
| 89 | ABC transporters_Homo sapiens_hsa02010 | 0.34983550 |
| 90 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.33830269 |
| 91 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.33188887 |
| 92 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.32722965 |
| 93 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.32266124 |
| 94 | Base excision repair_Homo sapiens_hsa03410 | 0.29405064 |
| 95 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.29214161 |
| 96 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.28640347 |
| 97 | Purine metabolism_Homo sapiens_hsa00230 | 0.28440127 |
| 98 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.27846780 |
| 99 | Insulin secretion_Homo sapiens_hsa04911 | 0.26077028 |
| 100 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.25836388 |

