NRBF2P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1homocysteine metabolic process (GO:0050667)7.24977405
2regulation of plasminogen activation (GO:0010755)6.72086827
3cysteine metabolic process (GO:0006534)6.69560133
4folic acid-containing compound biosynthetic process (GO:0009396)6.52858361
5tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)6.30287741
6RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)6.30287741
7segment specification (GO:0007379)6.14205543
8sulfur amino acid catabolic process (GO:0000098)5.91416867
9purine nucleotide salvage (GO:0032261)5.85186270
10adenosine metabolic process (GO:0046085)5.76539171
11epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)5.72205867
12inner ear receptor cell development (GO:0060119)5.25684588
13acrosome assembly (GO:0001675)5.24954146
14white fat cell differentiation (GO:0050872)4.89363770
15inner mitochondrial membrane organization (GO:0007007)4.78408378
16cochlea development (GO:0090102)4.71638446
17innervation (GO:0060384)4.59428445
18cartilage morphogenesis (GO:0060536)4.55418183
19viral transcription (GO:0019083)4.46092015
20galactose catabolic process (GO:0019388)4.42251974
21negative regulation of DNA biosynthetic process (GO:2000279)4.39238147
22translational termination (GO:0006415)4.27874354
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.22530711
24mitochondrial respiratory chain complex I assembly (GO:0032981)4.22530711
25NADH dehydrogenase complex assembly (GO:0010257)4.22530711
26pteridine-containing compound biosynthetic process (GO:0042559)4.15348861
27behavioral response to nicotine (GO:0035095)4.09519623
28galactose metabolic process (GO:0006012)4.06741432
29cell migration involved in heart development (GO:0060973)3.95333615
30alternative mRNA splicing, via spliceosome (GO:0000380)3.90961926
31CENP-A containing nucleosome assembly (GO:0034080)3.89991354
32negative regulation of catenin import into nucleus (GO:0035414)3.84664419
33serine family amino acid catabolic process (GO:0009071)3.82225873
34establishment of protein localization to mitochondrial membrane (GO:0090151)3.79269518
35negative regulation of keratinocyte proliferation (GO:0010839)3.74445330
36microtubule nucleation (GO:0007020)3.73274389
37ribosomal small subunit assembly (GO:0000028)3.69400190
38regulation of gonadotropin secretion (GO:0032276)3.66892694
39cilium or flagellum-dependent cell motility (GO:0001539)3.64627977
40chromatin remodeling at centromere (GO:0031055)3.60785310
41otic vesicle formation (GO:0030916)3.59368793
42negative regulation of Ras GTPase activity (GO:0034261)3.58834591
43IMP biosynthetic process (GO:0006188)3.57729431
44histone H4-K12 acetylation (GO:0043983)3.53436187
45negative regulation of interleukin-1 beta production (GO:0032691)3.49588420
46mitochondrial RNA metabolic process (GO:0000959)3.42729391
47epithelial cilium movement (GO:0003351)3.40890898
48positive regulation of endothelial cell differentiation (GO:0045603)3.38673944
49SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.35115208
50adult feeding behavior (GO:0008343)3.35115172
51protein-chromophore linkage (GO:0018298)3.34609447
52cotranslational protein targeting to membrane (GO:0006613)3.34049831
53translational elongation (GO:0006414)3.33349010
54L-serine metabolic process (GO:0006563)3.30131359
55IMP metabolic process (GO:0046040)3.28465513
56cellular protein complex disassembly (GO:0043624)3.27722232
57rRNA methylation (GO:0031167)3.26290973
58protein targeting to ER (GO:0045047)3.23254442
59nephron epithelium morphogenesis (GO:0072088)3.22237112
60nephron tubule morphogenesis (GO:0072078)3.22237112
61protein complex biogenesis (GO:0070271)3.20798313
62mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.20478460
63regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.16980989
64regulation of vitamin D biosynthetic process (GO:0060556)3.14692812
65tetrahydrofolate metabolic process (GO:0046653)3.14610748
66establishment of protein localization to endoplasmic reticulum (GO:0072599)3.10834247
67protein-cofactor linkage (GO:0018065)3.10277816
68sulfur amino acid biosynthetic process (GO:0000097)3.06178324
69spermatid nucleus differentiation (GO:0007289)3.06003911
70rRNA modification (GO:0000154)3.05554392
71tRNA modification (GO:0006400)3.05264588
72mRNA splice site selection (GO:0006376)3.04645919
73viral life cycle (GO:0019058)3.03656418
74DNA replication-independent nucleosome assembly (GO:0006336)3.01521021
75DNA replication-independent nucleosome organization (GO:0034724)3.01521021
76folic acid-containing compound metabolic process (GO:0006760)2.99125558
77cellular protein complex localization (GO:0034629)2.98540362
78behavioral fear response (GO:0001662)2.97335696
79behavioral defense response (GO:0002209)2.97335696
80interkinetic nuclear migration (GO:0022027)2.94911746
81desmosome organization (GO:0002934)2.93583403
82chaperone-mediated protein transport (GO:0072321)2.92645679
83epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.92308970
84negative regulation of oligodendrocyte differentiation (GO:0048715)2.92222746
85serine family amino acid biosynthetic process (GO:0009070)2.92158182
86purine-containing compound salvage (GO:0043101)2.91678216
87histone exchange (GO:0043486)2.90020783
88mitochondrial respiratory chain complex assembly (GO:0033108)2.89304592
89regulation of sequestering of triglyceride (GO:0010889)2.89246095
90ATP synthesis coupled proton transport (GO:0015986)2.89112695
91energy coupled proton transport, down electrochemical gradient (GO:0015985)2.89112695
92protein localization to endoplasmic reticulum (GO:0070972)2.88325807
93negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.87872546
94negative regulation of telomerase activity (GO:0051974)2.86207173
95dopaminergic neuron differentiation (GO:0071542)2.85692073
96maturation of SSU-rRNA (GO:0030490)2.85070893
97GMP metabolic process (GO:0046037)2.84913394
98nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.84621165
99phosphatidylglycerol biosynthetic process (GO:0006655)2.82177974
100pattern specification involved in kidney development (GO:0061004)11.2691664

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse8.74604093
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.16844678
3EZH2_22144423_ChIP-Seq_EOC_Human3.47119222
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.64685502
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.61744507
6GBX2_23144817_ChIP-Seq_PC3_Human2.57885747
7FUS_26573619_Chip-Seq_HEK293_Human2.45769418
8VDR_22108803_ChIP-Seq_LS180_Human2.34657545
9POU5F1_16153702_ChIP-ChIP_HESCs_Human2.22988770
10CBX2_27304074_Chip-Seq_ESCs_Mouse2.19860224
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14033071
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.10227186
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.03242224
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.00267022
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.96282059
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.96282059
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.96282059
18RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.91299184
19GABP_17652178_ChIP-ChIP_JURKAT_Human1.89755449
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87153863
21STAT6_21828071_ChIP-Seq_BEAS2B_Human1.79457290
22ZNF274_21170338_ChIP-Seq_K562_Hela1.77992664
23EWS_26573619_Chip-Seq_HEK293_Human1.77390201
24MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.71107988
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.68887585
26TP63_19390658_ChIP-ChIP_HaCaT_Human1.66996220
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65794381
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61904432
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59546367
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.57961013
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.57961013
32CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54748322
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.53112997
34TP53_20018659_ChIP-ChIP_R1E_Mouse1.48303301
35TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44636793
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42003133
37P300_19829295_ChIP-Seq_ESCs_Human1.40527659
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.39353828
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39170870
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37450262
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.36844001
42RNF2_27304074_Chip-Seq_NSC_Mouse1.35514519
43BCAT_22108803_ChIP-Seq_LS180_Human1.34302668
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.33663151
45TP53_22573176_ChIP-Seq_HFKS_Human1.30120233
46TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29480672
47TRIM28_21343339_ChIP-Seq_HEK293_Human1.28804648
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27968602
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27647051
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25312764
51KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24685629
52MYC_19079543_ChIP-ChIP_MESCs_Mouse1.24104409
53KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.22217339
54CDX2_22108803_ChIP-Seq_LS180_Human1.15390022
55ELK1_19687146_ChIP-ChIP_HELA_Human1.14253270
56CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.14190933
57XRN2_22483619_ChIP-Seq_HELA_Human1.13799055
58SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13602679
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12887190
60SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11624256
61MYC_18555785_ChIP-Seq_MESCs_Mouse1.09536430
62CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08690931
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07927837
64TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07414265
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07273401
66SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.06594958
67THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06498993
68E2F7_22180533_ChIP-Seq_HELA_Human1.01404377
69SOX2_16153702_ChIP-ChIP_HESCs_Human1.01385884
70TCF4_22108803_ChIP-Seq_LS180_Human1.01046515
71REST_21632747_ChIP-Seq_MESCs_Mouse1.00659964
72FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.00309892
73CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00114392
74STAT1_20625510_ChIP-Seq_HELA_Human0.99430384
75ZFP57_27257070_Chip-Seq_ESCs_Mouse0.98958331
76POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98444088
77SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98199746
78RUNX2_22187159_ChIP-Seq_PCA_Human0.98129829
79EZH2_27294783_Chip-Seq_NPCs_Mouse0.98082834
80NCOR_22424771_ChIP-Seq_293T_Human0.97088725
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96860858
82SALL1_21062744_ChIP-ChIP_HESCs_Human0.96204145
83SOX2_22085726_ChIP-Seq_NPCs_Mouse0.95993355
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95668899
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95049160
86JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.94042815
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91378361
88SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.90858129
89CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.90724027
90NFE2_27457419_Chip-Seq_LIVER_Mouse0.90433369
91CBP_20019798_ChIP-Seq_JUKART_Human0.90284909
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90284909
93ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89221181
94SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.89115161
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88647282
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87775129
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86879855
98NANOG_16153702_ChIP-ChIP_HESCs_Human0.86506429
99REST_18959480_ChIP-ChIP_MESCs_Mouse0.86347450
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.81997677

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis6.32300410
2MP0000569_abnormal_digit_pigmentation6.26341219
3MP0002938_white_spotting4.64750836
4MP0003136_yellow_coat_color3.81315611
5MP0008995_early_reproductive_senescence3.08136432
6MP0005646_abnormal_pituitary_gland3.06611175
7MP0005174_abnormal_tail_pigmentation2.46508425
8MP0003880_abnormal_central_pattern2.46445062
9MP0005367_renal/urinary_system_phenotyp2.43617261
10MP0000516_abnormal_urinary_system2.43617261
11MP0003705_abnormal_hypodermis_morpholog2.31225157
12MP0005360_urolithiasis2.29814681
13MP0009379_abnormal_foot_pigmentation2.24208359
14MP0003183_abnormal_peptide_metabolism2.21984477
15MP0004133_heterotaxia2.20999865
16MP0002095_abnormal_skin_pigmentation2.06883453
17MP0005670_abnormal_white_adipose2.05218137
18MP0000631_abnormal_neuroendocrine_gland2.01222787
19MP0004885_abnormal_endolymph1.99302935
20MP0003787_abnormal_imprinting1.98489566
21MP0002736_abnormal_nociception_after1.88140552
22MP0006292_abnormal_olfactory_placode1.83788865
23MP0003315_abnormal_perineum_morphology1.77529425
24MP0000778_abnormal_nervous_system1.56166481
25MP0000013_abnormal_adipose_tissue1.47251178
26MP0003806_abnormal_nucleotide_metabolis1.46571924
27MP0000371_diluted_coat_color1.41819833
28MP0000026_abnormal_inner_ear1.41664142
29MP0005551_abnormal_eye_electrophysiolog1.36948630
30MP0001984_abnormal_olfaction1.36815431
31MP0001968_abnormal_touch/_nociception1.36452437
32MP0001293_anophthalmia1.35442878
33MP0002277_abnormal_respiratory_mucosa1.33391375
34MP0001502_abnormal_circadian_rhythm1.32041908
35MP0002653_abnormal_ependyma_morphology1.29935873
36MP0001764_abnormal_homeostasis1.27402771
37MP0001661_extended_life_span1.26037561
38MP0003942_abnormal_urinary_system1.22651444
39MP0000534_abnormal_ureter_morphology1.21575666
40MP0002876_abnormal_thyroid_physiology1.19732164
41MP0010030_abnormal_orbit_morphology1.16182039
42MP0000372_irregular_coat_pigmentation1.15927868
43MP0002396_abnormal_hematopoietic_system1.15343243
44MP0002928_abnormal_bile_duct1.14928496
45MP0005171_absent_coat_pigmentation1.14503262
46MP0006072_abnormal_retinal_apoptosis1.13548615
47MP0001529_abnormal_vocalization1.11896693
48MP0001286_abnormal_eye_development1.07792832
49MP0002697_abnormal_eye_size1.06827872
50MP0002735_abnormal_chemical_nociception1.05831981
51MP0000647_abnormal_sebaceous_gland1.02298509
52MP0001485_abnormal_pinna_reflex1.01794218
53MP0003941_abnormal_skin_development1.00590980
54MP0003938_abnormal_ear_development1.00371748
55MP0003186_abnormal_redox_activity0.97131246
56MP0002282_abnormal_trachea_morphology0.97111971
57MP0001919_abnormal_reproductive_system0.96931253
58MP0006276_abnormal_autonomic_nervous0.96572350
59MP0003567_abnormal_fetal_cardiomyocyte0.94238779
60MP0002075_abnormal_coat/hair_pigmentati0.94228265
61MP0005377_hearing/vestibular/ear_phenot0.91181454
62MP0003878_abnormal_ear_physiology0.91181454
63MP0002837_dystrophic_cardiac_calcinosis0.90239559
64MP0005084_abnormal_gallbladder_morpholo0.89796133
65MP0002234_abnormal_pharynx_morphology0.88261380
66MP0003959_abnormal_lean_body0.85350948
67MP0002638_abnormal_pupillary_reflex0.84180148
68MP0005253_abnormal_eye_physiology0.83425499
69MP0005187_abnormal_penis_morphology0.83374788
70MP0005332_abnormal_amino_acid0.81866945
71MP0002069_abnormal_eating/drinking_beha0.75721862
72MP0001963_abnormal_hearing_physiology0.74300405
73MP0004142_abnormal_muscle_tone0.72335836
74MP0005195_abnormal_posterior_eye0.71876686
75MP0001486_abnormal_startle_reflex0.70950295
76MP0003121_genomic_imprinting0.70597711
77MP0009745_abnormal_behavioral_response0.69428678
78MP0002295_abnormal_pulmonary_circulatio0.69105751
79MP0002734_abnormal_mechanical_nocicepti0.68039663
80MP0003937_abnormal_limbs/digits/tail_de0.68031218
81MP0001324_abnormal_eye_pigmentation0.67096332
82MP0001186_pigmentation_phenotype0.66320955
83MP0009053_abnormal_anal_canal0.65804944
84MP0004742_abnormal_vestibular_system0.64366999
85MP0009250_abnormal_appendicular_skeleto0.64072562
86MP0005248_abnormal_Harderian_gland0.63826254
87MP0002971_abnormal_brown_adipose0.62902064
88MP0008872_abnormal_physiological_respon0.62300497
89MP0003890_abnormal_embryonic-extraembry0.60816469
90MP0002752_abnormal_somatic_nervous0.60684043
91MP0003936_abnormal_reproductive_system0.60460975
92MP0000955_abnormal_spinal_cord0.60395004
93MP0002184_abnormal_innervation0.59876551
94MP0004147_increased_porphyrin_level0.57788809
95MP0009046_muscle_twitch0.57466863
96MP0002210_abnormal_sex_determination0.57278416
97MP0005410_abnormal_fertilization0.57199038
98MP0003698_abnormal_male_reproductive0.56781152
99MP0002160_abnormal_reproductive_system0.56589779
100MP0001944_abnormal_pancreas_morphology0.56145111

Predicted human phenotypes

RankGene SetZ-score
1Hyperalaninemia (HP:0003348)6.54820678
2Abnormality of pyruvate family amino acid metabolism (HP:0010915)6.54820678
3Abnormality of alanine metabolism (HP:0010916)6.54820678
4Constricted visual fields (HP:0001133)5.03844458
5Congenital sensorineural hearing impairment (HP:0008527)4.23751959
6Chronic hepatic failure (HP:0100626)4.16694136
7Reticulocytopenia (HP:0001896)3.92979135
8Maternal diabetes (HP:0009800)3.87608216
9Spontaneous hematomas (HP:0007420)3.87537666
10Abnormal umbilical cord blood vessels (HP:0011403)3.46428517
11Single umbilical artery (HP:0001195)3.46428517
12Abnormality of the fetal cardiovascular system (HP:0010948)3.46428517
13Septo-optic dysplasia (HP:0100842)3.40450305
14Cortical visual impairment (HP:0100704)3.39424474
15Esophageal varix (HP:0002040)3.18285733
16Hypoplasia of the pons (HP:0012110)3.13286764
17Abnormality of the pons (HP:0007361)2.98927592
18Abnormality of serum amino acid levels (HP:0003112)2.96466545
19Patchy hypopigmentation of hair (HP:0011365)2.95479091
20White forelock (HP:0002211)2.87459700
21Partial duplication of thumb phalanx (HP:0009944)2.85900279
22Duplicated collecting system (HP:0000081)2.79954180
23Decreased electroretinogram (ERG) amplitude (HP:0000654)2.79561114
24Absent septum pellucidum (HP:0001331)2.75846864
25True hermaphroditism (HP:0010459)2.74984072
26Birth length less than 3rd percentile (HP:0003561)2.69221102
27Pancreatic cysts (HP:0001737)2.68404468
28Pancreatic fibrosis (HP:0100732)2.67014877
29Chronic otitis media (HP:0000389)2.65815256
30Duplication of thumb phalanx (HP:0009942)2.63801659
31Abnormality of the renal collecting system (HP:0004742)2.58323144
32Poor speech (HP:0002465)2.52464455
33Abnormality of homocysteine metabolism (HP:0010919)2.51260706
34Homocystinuria (HP:0002156)2.51260706
35Abnormal respiratory motile cilium morphology (HP:0005938)2.50541257
36Abnormal respiratory epithelium morphology (HP:0012253)2.50541257
37Midline defect of the nose (HP:0004122)2.49108384
38Stenosis of the external auditory canal (HP:0000402)2.46525248
39Partial duplication of the phalanx of hand (HP:0009999)2.44478379
40Macrocytic anemia (HP:0001972)2.39030518
41Action tremor (HP:0002345)2.38156687
42Aplasia/Hypoplasia of the uvula (HP:0010293)2.37185081
43Hyperglycinemia (HP:0002154)2.32858059
44Hypoplastic left heart (HP:0004383)2.30178641
45Abnormal number of erythroid precursors (HP:0012131)2.28233531
46Pendular nystagmus (HP:0012043)2.28228033
47Small epiphyses (HP:0010585)2.26320946
48Abnormality of the septum pellucidum (HP:0007375)2.25342545
49Abnormality of cells of the erythroid lineage (HP:0012130)2.20300138
50Chromosomal breakage induced by crosslinking agents (HP:0003221)2.19471612
51Chromsome breakage (HP:0040012)2.18997045
52Split foot (HP:0001839)2.17449323
53Oligomenorrhea (HP:0000876)2.17141966
54Abnormality of sulfur amino acid metabolism (HP:0004339)2.15625264
55Abnormal biliary tract physiology (HP:0012439)2.14401904
56Bile duct proliferation (HP:0001408)2.14401904
57Abnormality of midbrain morphology (HP:0002418)2.13060854
58Molar tooth sign on MRI (HP:0002419)2.13060854
59Conjunctival telangiectasia (HP:0000524)2.11378415
60Anencephaly (HP:0002323)2.06579789
61Cystic liver disease (HP:0006706)2.03929979
62Gastrointestinal atresia (HP:0002589)2.01607777
63Nephronophthisis (HP:0000090)2.00662890
64Pallor (HP:0000980)2.00193890
65Oligodactyly (hands) (HP:0001180)1.98831674
66Chronic sinusitis (HP:0011109)1.98511692
673-Methylglutaconic aciduria (HP:0003535)1.97243172
68Shawl scrotum (HP:0000049)1.97234607
69Ectopic anus (HP:0004397)1.96217665
70Anophthalmia (HP:0000528)1.95875678
71Anorexia (HP:0002039)1.95512937
72Visceral angiomatosis (HP:0100761)1.95306606
73Ectopic kidney (HP:0000086)1.93489907
74Abnormality of the umbilical cord (HP:0010881)1.92199762
75Attenuation of retinal blood vessels (HP:0007843)1.91810213
76Arteriovenous malformation (HP:0100026)1.90577176
77Triphalangeal thumb (HP:0001199)1.90526708
78Intestinal atresia (HP:0011100)1.89263032
79Absent thumb (HP:0009777)1.88941067
80Delayed CNS myelination (HP:0002188)1.87422885
81Microcytic anemia (HP:0001935)1.86670741
82Meckel diverticulum (HP:0002245)1.84245586
83Generalized aminoaciduria (HP:0002909)1.82556561
84Hypoplastic heart (HP:0001961)1.82277445
85Abnormality of the labia minora (HP:0012880)1.82008431
86Esophageal atresia (HP:0002032)1.80142790
87Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78009226
88Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.76642921
89Optic nerve coloboma (HP:0000588)1.76076935
90Chorioretinal coloboma (HP:0000567)1.75953710
91Broad distal phalanx of finger (HP:0009836)1.73734925
92Portal hypertension (HP:0001409)1.73455393
93Epileptic encephalopathy (HP:0200134)1.73049802
94Abnormality of the carotid arteries (HP:0005344)1.72608379
95Heterochromia iridis (HP:0001100)1.71192235
96Chorioretinal atrophy (HP:0000533)1.70279095
97Supernumerary spleens (HP:0009799)1.69471041
98Occipital encephalocele (HP:0002085)1.66951581
99Hemivertebrae (HP:0002937)1.66947387
100Hemangiomatosis (HP:0007461)1.66767565

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB23.76110818
2NTRK23.57634005
3PIM23.49270752
4BMPR1B3.13890750
5PNCK2.72330937
6MAP3K32.64024658
7VRK22.55510941
8CDK92.49318168
9MAP2K32.48890905
10TNIK2.36369336
11DYRK1B2.20298067
12ACVR1B2.15606644
13TAF12.08846586
14TGFBR12.01676251
15PASK1.81796103
16NTRK31.71440411
17SGK4941.70279208
18SGK2231.70279208
19TSSK61.67057805
20MARK11.63147365
21DYRK21.59472779
22NLK1.58302669
23FGR1.56526245
24ZAK1.54884487
25JAK31.48529723
26PRKD31.40242966
27BCKDK1.38968090
28CCNB11.38679721
29CDK81.32930533
30CDC71.32304347
31RPS6KB21.28150873
32NUAK11.22953833
33VRK11.16562342
34CDK191.13999234
35WNK41.00974064
36SGK20.98972624
37TLK10.97249159
38ERBB20.95312901
39MUSK0.93121290
40WEE10.92950940
41DAPK30.92146089
42BUB10.91303698
43DYRK30.89648755
44CAMK2D0.89466333
45CDK60.88644509
46CASK0.88147969
47MAP3K50.87608538
48STK160.83925216
49MAPK150.81307368
50MAP3K110.81306086
51MAP2K70.80883989
52ADRBK10.78948704
53CAMK2B0.78014024
54SIK20.77686526
55PLK20.74883041
56MAP3K40.72299012
57PDK20.68934204
58EIF2AK30.68820752
59EPHA40.68332851
60FLT30.68027966
61PBK0.67346852
62PLK30.66477884
63WNK30.66227146
64FGFR20.64573937
65TYRO30.60586846
66PIM10.59927674
67CSNK1A10.56893340
68CHEK20.56084574
69STK110.53057950
70RPS6KB10.52599371
71CAMK10.52013193
72CAMK2G0.51856295
73PTK60.50576086
74PKN10.50376039
75MAP4K10.48796199
76JAK20.48542091
77PIK3CA0.45515249
78TTK0.45314304
79PHKG10.42148776
80PHKG20.42148776
81NEK60.41947270
82ABL20.41285551
83CDK50.40955007
84UHMK10.40569701
85PKN20.38414663
86EIF2AK20.36466077
87SGK10.36374480
88BRSK20.35655247
89CSNK1G10.35125001
90AKT30.34516186
91AURKA0.33019295
92PRKCE0.32761462
93TRIM280.32761223
94MTOR0.32191094
95DYRK1A0.32065650
96CAMK2A0.31969690
97SGK30.31578105
98FGFR10.30871338
99ADRBK20.30242482
100CSNK2A10.30059730

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006703.94072569
2Ribosome_Homo sapiens_hsa030103.85307213
3Oxidative phosphorylation_Homo sapiens_hsa001903.62405244
4Arginine biosynthesis_Homo sapiens_hsa002203.15775901
5Sulfur relay system_Homo sapiens_hsa041223.06736754
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.96854545
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.53198229
8Parkinsons disease_Homo sapiens_hsa050122.53047324
9Collecting duct acid secretion_Homo sapiens_hsa049662.40503678
10Nicotine addiction_Homo sapiens_hsa050332.39773683
11Huntingtons disease_Homo sapiens_hsa050161.91835460
12Alzheimers disease_Homo sapiens_hsa050101.89980713
13Proteasome_Homo sapiens_hsa030501.89078200
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.88261897
15Nitrogen metabolism_Homo sapiens_hsa009101.88240244
16Fanconi anemia pathway_Homo sapiens_hsa034601.87333495
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.81969398
18Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.77044960
19GABAergic synapse_Homo sapiens_hsa047271.74046297
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.72652841
21Cardiac muscle contraction_Homo sapiens_hsa042601.72092884
22Morphine addiction_Homo sapiens_hsa050321.69097960
23Basal transcription factors_Homo sapiens_hsa030221.68943577
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.67512762
25Sulfur metabolism_Homo sapiens_hsa009201.63928401
26Folate biosynthesis_Homo sapiens_hsa007901.53273480
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42360634
28Galactose metabolism_Homo sapiens_hsa000521.41700093
29Homologous recombination_Homo sapiens_hsa034401.41121116
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.36594456
31Selenocompound metabolism_Homo sapiens_hsa004501.35225235
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.32422203
33RNA degradation_Homo sapiens_hsa030181.25937445
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.18485530
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16434162
36Regulation of autophagy_Homo sapiens_hsa041401.15912939
37Glutamatergic synapse_Homo sapiens_hsa047241.14267922
38Linoleic acid metabolism_Homo sapiens_hsa005911.14072991
39Butanoate metabolism_Homo sapiens_hsa006501.09879009
40Vitamin digestion and absorption_Homo sapiens_hsa049771.08124962
41Taste transduction_Homo sapiens_hsa047421.03877673
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02031597
43Olfactory transduction_Homo sapiens_hsa047401.01167558
44Mismatch repair_Homo sapiens_hsa034300.97669504
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96315442
46Serotonergic synapse_Homo sapiens_hsa047260.93120756
47Biosynthesis of amino acids_Homo sapiens_hsa012300.88460830
48Steroid hormone biosynthesis_Homo sapiens_hsa001400.85286599
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84667086
50Retinol metabolism_Homo sapiens_hsa008300.84298398
51Spliceosome_Homo sapiens_hsa030400.82811607
52Phototransduction_Homo sapiens_hsa047440.81074726
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78238412
54Basal cell carcinoma_Homo sapiens_hsa052170.77067248
55Ether lipid metabolism_Homo sapiens_hsa005650.75279997
56Protein export_Homo sapiens_hsa030600.74803491
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74214484
58Synaptic vesicle cycle_Homo sapiens_hsa047210.73716061
59Circadian entrainment_Homo sapiens_hsa047130.70999277
60Dopaminergic synapse_Homo sapiens_hsa047280.67792195
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66259974
62Metabolic pathways_Homo sapiens_hsa011000.66146814
63Chemical carcinogenesis_Homo sapiens_hsa052040.62382937
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60383750
65Cholinergic synapse_Homo sapiens_hsa047250.57142512
66RNA polymerase_Homo sapiens_hsa030200.56257384
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54118520
68Peroxisome_Homo sapiens_hsa041460.53280897
69Rheumatoid arthritis_Homo sapiens_hsa053230.52022678
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51809349
71Purine metabolism_Homo sapiens_hsa002300.51361682
72Arginine and proline metabolism_Homo sapiens_hsa003300.50796562
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48011287
74Mineral absorption_Homo sapiens_hsa049780.47204427
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46958312
76TGF-beta signaling pathway_Homo sapiens_hsa043500.45579659
77RNA transport_Homo sapiens_hsa030130.44094268
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.43912822
79Propanoate metabolism_Homo sapiens_hsa006400.43263717
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42039720
81Hippo signaling pathway_Homo sapiens_hsa043900.41957327
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.41735272
83Vibrio cholerae infection_Homo sapiens_hsa051100.39888256
84Hedgehog signaling pathway_Homo sapiens_hsa043400.39626793
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36573583
86Ras signaling pathway_Homo sapiens_hsa040140.35169473
87Arachidonic acid metabolism_Homo sapiens_hsa005900.33855247
88Nucleotide excision repair_Homo sapiens_hsa034200.31848429
89Cell cycle_Homo sapiens_hsa041100.29292864
90DNA replication_Homo sapiens_hsa030300.29028705
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28632106
92p53 signaling pathway_Homo sapiens_hsa041150.27078900
93Non-homologous end-joining_Homo sapiens_hsa034500.26108326
94Alcoholism_Homo sapiens_hsa050340.25665389
95mRNA surveillance pathway_Homo sapiens_hsa030150.25067519
96Asthma_Homo sapiens_hsa053100.24126214
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21724605
98Tryptophan metabolism_Homo sapiens_hsa003800.19964371
99Wnt signaling pathway_Homo sapiens_hsa043100.19665476
100Axon guidance_Homo sapiens_hsa043600.16229489

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