NRBF2P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1microtubule nucleation (GO:0007020)5.98141267
2homocysteine metabolic process (GO:0050667)5.92332688
3regulation of plasminogen activation (GO:0010755)5.42456627
4limb bud formation (GO:0060174)5.26479998
5folic acid-containing compound biosynthetic process (GO:0009396)5.08519876
6adenosine metabolic process (GO:0046085)5.05865089
7cysteine metabolic process (GO:0006534)4.71154342
8purine nucleotide salvage (GO:0032261)4.63922246
9regulation of germinal center formation (GO:0002634)4.42553676
10alternative mRNA splicing, via spliceosome (GO:0000380)4.28041302
11cytoplasmic mRNA processing body assembly (GO:0033962)4.23923367
12positive regulation of gamma-delta T cell activation (GO:0046645)4.21672182
13mature B cell differentiation (GO:0002335)4.08864895
14neutrophil activation involved in immune response (GO:0002283)4.01630947
15desmosome organization (GO:0002934)3.97578409
16neural tube formation (GO:0001841)3.97155028
17RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.96174897
18tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.96174897
19mature B cell differentiation involved in immune response (GO:0002313)3.94365072
20leukotriene biosynthetic process (GO:0019370)3.91317374
21epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.89803055
22tachykinin receptor signaling pathway (GO:0007217)3.83491390
23negative regulation of interleukin-1 beta production (GO:0032691)3.81367700
24white fat cell differentiation (GO:0050872)3.80074694
25phosphatidylglycerol biosynthetic process (GO:0006655)3.62861926
26negative regulation of DNA biosynthetic process (GO:2000279)3.59627905
27sulfur amino acid catabolic process (GO:0000098)3.58468781
28corticosteroid receptor signaling pathway (GO:0031958)3.55595900
29lipoprotein transport (GO:0042953)3.55242146
30energy homeostasis (GO:0097009)3.54666767
31cartilage morphogenesis (GO:0060536)3.50489947
32negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.44831411
33hepatocyte apoptotic process (GO:0097284)3.39407923
34positive regulation of protein import into nucleus, translocation (GO:0033160)3.38240808
35protein-chromophore linkage (GO:0018298)3.36631308
36positive regulation of toll-like receptor signaling pathway (GO:0034123)3.35929831
37tryptophan metabolic process (GO:0006568)3.35714709
38negative regulation of Ras GTPase activity (GO:0034261)3.34582157
39muscle atrophy (GO:0014889)3.30462573
40phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.25896092
41regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.22702652
42histone H3-K4 trimethylation (GO:0080182)3.21086538
43positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.21043142
44regulation of vitamin D biosynthetic process (GO:0060556)3.19406343
45positive regulation of endothelial cell differentiation (GO:0045603)3.19177290
46behavioral response to pain (GO:0048266)3.17769390
47regulation of B cell receptor signaling pathway (GO:0050855)3.14312408
48primary amino compound metabolic process (GO:1901160)3.13378052
49histone H4-K12 acetylation (GO:0043983)3.11763486
50positive regulation of B cell differentiation (GO:0045579)3.10925389
51growth hormone receptor signaling pathway (GO:0060396)3.10024845
52histone-serine phosphorylation (GO:0035404)3.08486817
53regulation of gonadotropin secretion (GO:0032276)3.04654901
54negative regulation of T-helper cell differentiation (GO:0045623)3.02087041
55negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.02087041
56negative regulation of interleukin-1 production (GO:0032692)2.99325282
57mitochondrial RNA metabolic process (GO:0000959)2.96281538
58positive regulation of vascular permeability (GO:0043117)2.95699709
59centrosome localization (GO:0051642)2.94265383
60regulation of tight junction assembly (GO:2000810)2.92051083
61B cell receptor signaling pathway (GO:0050853)2.89817535
62positive regulation of uterine smooth muscle contraction (GO:0070474)2.88706532
63regulation of gamma-delta T cell activation (GO:0046643)2.88471612
64CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.86227782
65T-helper cell differentiation (GO:0042093)2.86227782
66positive regulation of mitotic sister chromatid separation (GO:1901970)2.86092352
67positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.86092352
68positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.86092352
69leukotriene metabolic process (GO:0006691)2.81471705
70negative regulation of keratinocyte proliferation (GO:0010839)2.80838573
71regulation of B cell differentiation (GO:0045577)2.79072430
72acrosome assembly (GO:0001675)2.77876084
73glial cell proliferation (GO:0014009)2.77178003
74cell migration in hindbrain (GO:0021535)2.70613897
75cell migration involved in heart development (GO:0060973)2.69910217
76adult feeding behavior (GO:0008343)2.69177380
77cellular response to growth hormone stimulus (GO:0071378)2.68438076
78regulation of sequestering of triglyceride (GO:0010889)2.65287027
79positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.64756597
80regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.64756597
81pathway-restricted SMAD protein phosphorylation (GO:0060389)2.63535006
82macrophage activation involved in immune response (GO:0002281)2.62940066
83cardiac ventricle formation (GO:0003211)2.62020653
84peptidyl-lysine trimethylation (GO:0018023)2.61556912
85regulation of gamma-delta T cell differentiation (GO:0045586)2.60475677
86regulation of interleukin-6 biosynthetic process (GO:0045408)2.59271516
87negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.59121668
88cellular response to ethanol (GO:0071361)2.58133107
89histone H3-K4 methylation (GO:0051568)2.56870542
90response to hydroperoxide (GO:0033194)2.56437333
91COPII vesicle coating (GO:0048208)2.56357247
92B cell proliferation (GO:0042100)2.55312019
93neutrophil activation (GO:0042119)2.54222372
94positive regulation of action potential (GO:0045760)2.52068497
95positive regulation of developmental pigmentation (GO:0048087)2.52042626
96neural crest cell development (GO:0014032)2.51711973
97drinking behavior (GO:0042756)2.48218790
98monocyte differentiation (GO:0030224)2.47780534
99indolalkylamine catabolic process (GO:0046218)2.46129082
100tryptophan catabolic process (GO:0006569)2.46129082

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.72661911
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.15102631
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.83448362
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.46983016
5SMAD_19615063_ChIP-ChIP_OVARY_Human3.46024229
6SCL_19346495_ChIP-Seq_HPC-7_Human3.06352861
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.03769096
8GATA1_22025678_ChIP-Seq_K562_Human2.62327942
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.48301833
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.47500682
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.37462774
12GBX2_23144817_ChIP-Seq_PC3_Human2.25871992
13VDR_24787735_ChIP-Seq_THP-1_Human2.17952072
14MYB_26560356_Chip-Seq_TH2_Human2.10178572
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.01331425
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.00084761
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.96430438
18ESR1_20079471_ChIP-ChIP_T-47D_Human1.89752417
19SALL1_21062744_ChIP-ChIP_HESCs_Human1.89583289
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86120078
21IRF8_27001747_Chip-Seq_BMDM_Mouse1.84266351
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.79085058
23SPI1_23127762_ChIP-Seq_K562_Human1.73670550
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71245775
25CTNNB1_20460455_ChIP-Seq_HCT116_Human1.70737809
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.65685331
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62997732
28CDX2_22108803_ChIP-Seq_LS180_Human1.62180651
29RXR_22108803_ChIP-Seq_LS180_Human1.60271706
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.57578543
31FOXM1_23109430_ChIP-Seq_U2OS_Human1.57424708
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54398494
33MYB_26560356_Chip-Seq_TH1_Human1.52872941
34TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.52844876
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.50440369
36VDR_22108803_ChIP-Seq_LS180_Human1.46942649
37BCAT_22108803_ChIP-Seq_LS180_Human1.46537448
38GATA3_26560356_Chip-Seq_TH2_Human1.44904964
39FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42979695
40SPI1_23547873_ChIP-Seq_NB4_Human1.42837584
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41325777
42CIITA_25753668_ChIP-Seq_RAJI_Human1.40756548
43GATA3_27048872_Chip-Seq_THYMUS_Human1.37486623
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36758947
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.35917240
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32329462
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.31114953
48RUNX_20019798_ChIP-Seq_JUKART_Human1.29894277
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27147647
50STAT3_23295773_ChIP-Seq_U87_Human1.27106677
51PKCTHETA_26484144_Chip-Seq_BREAST_Human1.26115132
52E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24559013
53VDR_24763502_ChIP-Seq_THP-1_Human1.24220302
54PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23501422
55DROSHA_22980978_ChIP-Seq_HELA_Human1.23013915
56PRDM14_20953172_ChIP-Seq_ESCs_Human1.19143396
57GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18574487
58TCF4_18268006_ChIP-ChIP_LS174T_Human1.17778459
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17703701
60CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16971852
61PU_27001747_Chip-Seq_BMDM_Mouse1.15037101
62BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13766345
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12308868
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12308868
65CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10191378
66CBP_20019798_ChIP-Seq_JUKART_Human1.09491520
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09491520
68TCF4_22108803_ChIP-Seq_LS180_Human1.08400118
69OCT1_27270436_Chip-Seq_PROSTATE_Human1.07896259
70KDM2B_26808549_Chip-Seq_REH_Human1.07216040
71RUNX2_22187159_ChIP-Seq_PCA_Human1.07126911
72FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.06528898
73TP53_16413492_ChIP-PET_HCT116_Human1.03049541
74FOXA2_19822575_ChIP-Seq_HepG2_Human1.01027334
75TCF4_23295773_ChIP-Seq_U87_Human1.00966819
76TP53_22573176_ChIP-Seq_HFKS_Human1.00251834
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99667218
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98855418
79AHR_22903824_ChIP-Seq_MCF-7_Human0.98284411
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98100414
81SMRT_27268052_Chip-Seq_Bcells_Human0.97693712
82GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96764768
83TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96216339
84BRD4_25478319_ChIP-Seq_HGPS_Human0.95911952
85EZH2_27294783_Chip-Seq_NPCs_Mouse0.94855323
86MYC_22102868_ChIP-Seq_BL_Human0.94822462
87GATA1_19941827_ChIP-Seq_MEL_Mouse0.93517598
88GATA2_19941826_ChIP-Seq_K562_Human0.93439451
89SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92822702
90POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92462599
91EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92452298
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92013171
93ARNT_22903824_ChIP-Seq_MCF-7_Human0.91900445
94ER_23166858_ChIP-Seq_MCF-7_Human0.91813489
95PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91021921
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90328137
97KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89428732
98FLI1_27457419_Chip-Seq_LIVER_Mouse0.88946861
99TP63_19390658_ChIP-ChIP_HaCaT_Human0.87863623
100FLI1_21867929_ChIP-Seq_TH2_Mouse0.84467015

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy5.32940965
2MP0000569_abnormal_digit_pigmentation4.41753032
3MP0005670_abnormal_white_adipose4.37689295
4MP0005360_urolithiasis4.13200910
5MP0003183_abnormal_peptide_metabolism3.64046135
6MP0002009_preneoplasia3.39066883
7MP0009697_abnormal_copulation3.37451416
8MP0005075_abnormal_melanosome_morpholog3.29974016
9MP0000516_abnormal_urinary_system2.96340532
10MP0005367_renal/urinary_system_phenotyp2.96340532
11MP0002736_abnormal_nociception_after2.91004661
12MP0002396_abnormal_hematopoietic_system2.90237812
13MP0000371_diluted_coat_color2.70783973
14MP0002735_abnormal_chemical_nociception2.52564167
15MP0001835_abnormal_antigen_presentation2.38418823
16MP0008057_abnormal_DNA_replication2.29927286
17MP0003705_abnormal_hypodermis_morpholog2.19567734
18MP0003724_increased_susceptibility_to1.94702688
19MP0004185_abnormal_adipocyte_glucose1.92594262
20MP0005171_absent_coat_pigmentation1.88802374
21MP0001800_abnormal_humoral_immune1.85520986
22MP0002166_altered_tumor_susceptibility1.73649465
23MP0001661_extended_life_span1.71281496
24MP0004381_abnormal_hair_follicle1.61575553
25MP0003763_abnormal_thymus_physiology1.60830585
26MP0002138_abnormal_hepatobiliary_system1.59320008
27MP0002938_white_spotting1.57192370
28MP0008995_early_reproductive_senescence1.49786901
29MP0005646_abnormal_pituitary_gland1.49559486
30MP0002006_tumorigenesis1.43950059
31MP0004808_abnormal_hematopoietic_stem1.30780335
32MP0001968_abnormal_touch/_nociception1.28284833
33MP0002075_abnormal_coat/hair_pigmentati1.27974153
34MP0000372_irregular_coat_pigmentation1.25969177
35MP0005666_abnormal_adipose_tissue1.22234560
36MP0002723_abnormal_immune_serum1.17380189
37MP0002095_abnormal_skin_pigmentation1.17288701
38MP0005000_abnormal_immune_tolerance1.17069521
39MP0004233_abnormal_muscle_weight1.16511254
40MP0005076_abnormal_cell_differentiation1.13642280
41MP0003172_abnormal_lysosome_physiology1.13009355
42MP0004264_abnormal_extraembryonic_tissu1.12747607
43MP0002452_abnormal_antigen_presenting1.12244647
44MP0005551_abnormal_eye_electrophysiolog1.11292089
45MP0005451_abnormal_body_composition1.10788999
46MP0009115_abnormal_fat_cell1.07509939
47MP0005220_abnormal_exocrine_pancreas1.02031693
48MP0004147_increased_porphyrin_level1.01851746
49MP0001545_abnormal_hematopoietic_system1.01820776
50MP0005397_hematopoietic_system_phenotyp1.01820776
51MP0002933_joint_inflammation1.00729026
52MP0002398_abnormal_bone_marrow1.00358485
53MP0000647_abnormal_sebaceous_gland0.99651714
54MP0000427_abnormal_hair_cycle0.98514447
55MP0002419_abnormal_innate_immunity0.97346155
56MP0005174_abnormal_tail_pigmentation0.92896452
57MP0003878_abnormal_ear_physiology0.91978867
58MP0005377_hearing/vestibular/ear_phenot0.91978867
59MP0003868_abnormal_feces_composition0.91583552
60MP0002420_abnormal_adaptive_immunity0.91531336
61MP0001958_emphysema0.90341538
62MP0001819_abnormal_immune_cell0.89601941
63MP0000858_altered_metastatic_potential0.89426217
64MP0003279_aneurysm0.85798887
65MP0000383_abnormal_hair_follicle0.84662955
66MP0002970_abnormal_white_adipose0.83293916
67MP0000716_abnormal_immune_system0.82192816
68MP0000013_abnormal_adipose_tissue0.81232740
69MP0000015_abnormal_ear_pigmentation0.80031972
70MP0001186_pigmentation_phenotype0.78243961
71MP0001790_abnormal_immune_system0.77931101
72MP0005387_immune_system_phenotype0.77931101
73MP0005310_abnormal_salivary_gland0.77458484
74MP0004134_abnormal_chest_morphology0.76853729
75MP0003656_abnormal_erythrocyte_physiolo0.76769967
76MP0008877_abnormal_DNA_methylation0.76141011
77MP0003436_decreased_susceptibility_to0.75324105
78MP0000703_abnormal_thymus_morphology0.75192862
79MP0000689_abnormal_spleen_morphology0.74243092
80MP0002722_abnormal_immune_system0.73311491
81MP0005164_abnormal_response_to0.72751006
82MP0005408_hypopigmentation0.69263561
83MP0010094_abnormal_chromosome_stability0.68259233
84MP0003077_abnormal_cell_cycle0.67787510
85MP0004043_abnormal_pH_regulation0.66535415
86MP0008872_abnormal_physiological_respon0.65072636
87MP0002876_abnormal_thyroid_physiology0.64139646
88MP0002971_abnormal_brown_adipose0.63838952
89MP0009764_decreased_sensitivity_to0.62674898
90MP0005375_adipose_tissue_phenotype0.62348277
91MP0002429_abnormal_blood_cell0.61849399
92MP0004924_abnormal_behavior0.60986556
93MP0005386_behavior/neurological_phenoty0.60986556
94MP0006072_abnormal_retinal_apoptosis0.59296875
95MP0001324_abnormal_eye_pigmentation0.58277367
96MP0003045_fibrosis0.58182407
97MP0000377_abnormal_hair_follicle0.58068253
98MP0001529_abnormal_vocalization0.56147975
99MP0004270_analgesia0.55325050
100MP0004130_abnormal_muscle_cell0.55248864

Predicted human phenotypes

RankGene SetZ-score
1Spontaneous hematomas (HP:0007420)6.19422227
2Abnormality of alanine metabolism (HP:0010916)4.86060003
3Hyperalaninemia (HP:0003348)4.86060003
4Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.86060003
5Long clavicles (HP:0000890)4.69223118
6Esophageal varix (HP:0002040)4.49117312
7Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)4.15520269
8Short 1st metacarpal (HP:0010034)4.15520269
9Short phalanx of the thumb (HP:0009660)3.82430276
10Broad ribs (HP:0000885)3.63644471
11Abnormality of the 1st metacarpal (HP:0010009)3.61994723
12Gastrointestinal infarctions (HP:0005244)3.61594750
13Myocardial infarction (HP:0001658)3.54635915
14Ureteral obstruction (HP:0006000)3.46688630
15Constricted visual fields (HP:0001133)3.44508535
16Gingival bleeding (HP:0000225)3.44463261
17Hepatoblastoma (HP:0002884)3.38058350
18Spontaneous abortion (HP:0005268)3.30532543
19Peritonitis (HP:0002586)3.28825754
20Congenital sensorineural hearing impairment (HP:0008527)3.17357414
21Fatigue (HP:0012378)3.17176372
22Abnormality of the fingertips (HP:0001211)3.05631511
23Aplasia/Hypoplasia of the sternum (HP:0006714)2.97925830
24White forelock (HP:0002211)2.97563470
25Arterial thrombosis (HP:0004420)2.91739452
26Abnormality of homocysteine metabolism (HP:0010919)2.81713229
27Homocystinuria (HP:0002156)2.81713229
28Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.81459610
29Anorexia (HP:0002039)2.78155919
30Thrombophlebitis (HP:0004418)2.72868004
31Recurrent bacterial skin infections (HP:0005406)2.63195801
32Abnormality of the labia minora (HP:0012880)2.62626583
33Ureteral stenosis (HP:0000071)2.59677508
34Conjunctival telangiectasia (HP:0000524)2.58064857
35Pulmonary embolism (HP:0002204)2.56906608
36Birth length less than 3rd percentile (HP:0003561)2.56718068
37Delayed closure of the anterior fontanelle (HP:0001476)2.53613897
38Decreased electroretinogram (ERG) amplitude (HP:0000654)2.49604866
39Portal hypertension (HP:0001409)2.48168926
40Decreased skull ossification (HP:0004331)2.40380337
41Elevated erythrocyte sedimentation rate (HP:0003565)2.39660378
42Chronic otitis media (HP:0000389)2.31766974
43Abnormality of the vasculature of the conjunctiva (HP:0008054)2.29418822
44Alacrima (HP:0000522)2.29309029
45Recurrent abscess formation (HP:0002722)2.29149599
46Abnormality of the hepatic vasculature (HP:0006707)2.26428145
47Spinal muscular atrophy (HP:0007269)2.23603195
48Chronic mucocutaneous candidiasis (HP:0002728)2.23008841
49Recurrent cutaneous fungal infections (HP:0011370)2.23008841
50Progressive cerebellar ataxia (HP:0002073)2.18821306
51Myositis (HP:0100614)2.18014635
52Patchy hypopigmentation of hair (HP:0011365)2.17971804
53Action tremor (HP:0002345)2.12515308
54Increased density of long bones (HP:0006392)2.11682510
55Hypoplastic labia majora (HP:0000059)2.07633442
56Hemoptysis (HP:0002105)2.06952141
57Chronic diarrhea (HP:0002028)2.06781092
58Epistaxis (HP:0000421)2.05745336
59Ileus (HP:0002595)2.05660650
60Abnormality of skull ossification (HP:0002703)2.05553925
61Congenital stationary night blindness (HP:0007642)2.05405990
62Decreased lacrimation (HP:0000633)2.04723177
63Cone-rod dystrophy (HP:0000548)2.03673407
64Chest pain (HP:0100749)2.03570699
65Oligomenorrhea (HP:0000876)2.02662705
66Hypopigmentation of the fundus (HP:0007894)2.01723737
67Chronic hepatic failure (HP:0100626)2.01293806
68Abnormality of the parietal bone (HP:0002696)2.01047516
69Pigmentary retinal degeneration (HP:0001146)1.99757837
70Pendular nystagmus (HP:0012043)1.98872646
71Abnormal umbilical cord blood vessels (HP:0011403)1.95747865
72Single umbilical artery (HP:0001195)1.95747865
73Abnormality of the fetal cardiovascular system (HP:0010948)1.95747865
74Anal stenosis (HP:0002025)1.94352161
75Amaurosis fugax (HP:0100576)1.94250177
76Deformed sella turcica (HP:0002681)1.92503314
77Abnormality of the labia majora (HP:0012881)1.91755709
78Genetic anticipation (HP:0003743)1.91600443
79Biconcave vertebral bodies (HP:0004586)1.90641499
80Short thumb (HP:0009778)1.86468509
81Microcytic anemia (HP:0001935)1.85147206
82Cavernous hemangioma (HP:0001048)1.84895278
83Abnormality of serum amino acid levels (HP:0003112)1.84145922
84Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.83916075
85Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.81182355
86Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.80686406
87Widely patent fontanelles and sutures (HP:0004492)1.80496364
88Abnormality of the pubic bones (HP:0003172)1.78671534
89Syringomyelia (HP:0003396)1.77110034
90Spinal cord lesions (HP:0100561)1.77110034
91Prominent nose (HP:0000448)1.74937164
92Orthostatic hypotension (HP:0001278)1.72478893
93Intestinal atresia (HP:0011100)1.72361077
94Abnormality of the carotid arteries (HP:0005344)1.72293461
95Facial hemangioma (HP:0000329)1.71960162
96Abnormality of sulfur amino acid metabolism (HP:0004339)1.69171656
97Abnormality of the peritoneum (HP:0002585)1.69163932
98Recurrent skin infections (HP:0001581)1.67836180
99Panhypogammaglobulinemia (HP:0003139)1.67769331
100Conjugated hyperbilirubinemia (HP:0002908)1.67512726

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K33.68807350
2MAP4K13.24633920
3MAP3K62.90556246
4MARK32.89842558
5MAP3K32.82800725
6JAK32.75725967
7PINK12.69749557
8CDK122.55990560
9SGK22.23035359
10MAP4K22.21396496
11CAMK1D2.19021474
12FRK2.15672991
13CDK92.15508196
14BLK2.06717645
15FGR2.00471715
16PIK3CG1.96458900
17KSR11.93718711
18SGK2231.83639525
19SGK4941.83639525
20BRSK21.81226131
21DYRK1B1.79892704
22SIK21.79631259
23CDK191.79245795
24RPS6KB21.71296433
25CCNB11.68245786
26CDK61.67009984
27MAP2K71.65905696
28SGK31.56691753
29MAP3K41.53488338
30CAMK1G1.52588321
31ACVR1B1.52373948
32KIT1.44432182
33CSF1R1.43972559
34SYK1.38176236
35PIM11.38018389
36YES11.25588115
37BTK1.25033421
38TAOK31.22919506
39AKT31.21271986
40TEC1.19654702
41JAK21.16960978
42MAP3K51.12785351
43GRK11.06357897
44GRK61.01292725
45MAPK130.95688520
46PIM20.91512100
47NEK60.91489655
48KSR20.90878669
49BRD40.86012851
50RAF10.84935701
51TYK20.80106350
52MAP3K20.79272355
53MAP2K40.78921268
54MAP3K140.77256583
55PTK2B0.76065053
56UHMK10.74437700
57STK110.73673605
58PRKAA20.71515716
59OXSR10.68025534
60LYN0.66948147
61ABL10.66588456
62NLK0.65858934
63NEK90.64654692
64WNK10.63226772
65LCK0.62612045
66PRKAA10.62435782
67IKBKE0.57775703
68FLT30.54694561
69IKBKB0.54410155
70MAP2K10.53911650
71RPS6KB10.53896026
72MAP3K10.50802324
73STK100.50240818
74TRPM70.49444749
75BUB10.48926649
76SGK10.47963967
77RET0.47222361
78MTOR0.46822460
79HIPK20.46327996
80SIK30.45524935
81HCK0.44855242
82IRAK40.44379297
83TNIK0.42304242
84NTRK30.39672262
85CSNK1A1L0.39040281
86TXK0.38610104
87EGFR0.36038044
88CSNK1A10.35845999
89ITK0.35050899
90NTRK20.33702110
91CHEK20.32673676
92MUSK0.30282385
93CHUK0.30137855
94IRAK10.30028552
95MAPK10.29226972
96CAMK10.27023779
97PRKCI0.25245845
98ERBB20.23360341
99STK40.23107340
100CHEK10.21722751

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053102.50649692
2Vitamin digestion and absorption_Homo sapiens_hsa049772.28076362
3One carbon pool by folate_Homo sapiens_hsa006702.26440931
4Graft-versus-host disease_Homo sapiens_hsa053322.05273015
5Arginine biosynthesis_Homo sapiens_hsa002201.95394725
6Autoimmune thyroid disease_Homo sapiens_hsa053201.87486757
7Intestinal immune network for IgA production_Homo sapiens_hsa046721.83516220
8Staphylococcus aureus infection_Homo sapiens_hsa051501.81333427
9Other glycan degradation_Homo sapiens_hsa005111.77533994
10Influenza A_Homo sapiens_hsa051641.76202941
11Allograft rejection_Homo sapiens_hsa053301.73789500
12B cell receptor signaling pathway_Homo sapiens_hsa046621.68481952
13Leishmaniasis_Homo sapiens_hsa051401.62924518
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.59948400
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.56923711
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.48902284
17Fatty acid biosynthesis_Homo sapiens_hsa000611.45616338
18Systemic lupus erythematosus_Homo sapiens_hsa053221.45444340
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37299616
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.34707754
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.34017495
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33337147
23Osteoclast differentiation_Homo sapiens_hsa043801.30478791
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.28584929
25Type I diabetes mellitus_Homo sapiens_hsa049401.25523833
26Prolactin signaling pathway_Homo sapiens_hsa049171.25199732
27Measles_Homo sapiens_hsa051621.21507725
28Herpes simplex infection_Homo sapiens_hsa051681.20415949
29Thyroid cancer_Homo sapiens_hsa052161.18762585
30Ether lipid metabolism_Homo sapiens_hsa005651.17154173
31Taste transduction_Homo sapiens_hsa047421.16270527
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15770555
33Tuberculosis_Homo sapiens_hsa051521.14781631
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14532832
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.11840454
36Chronic myeloid leukemia_Homo sapiens_hsa052201.02296203
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.01821259
38Rheumatoid arthritis_Homo sapiens_hsa053231.01197802
39Morphine addiction_Homo sapiens_hsa050321.00931714
40Toxoplasmosis_Homo sapiens_hsa051450.99645702
41Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97913212
42ErbB signaling pathway_Homo sapiens_hsa040120.96467568
43Hematopoietic cell lineage_Homo sapiens_hsa046400.93325181
44Hepatitis B_Homo sapiens_hsa051610.92600854
45Primary immunodeficiency_Homo sapiens_hsa053400.90991577
46Non-small cell lung cancer_Homo sapiens_hsa052230.90535436
47Glutamatergic synapse_Homo sapiens_hsa047240.87348606
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86843477
49T cell receptor signaling pathway_Homo sapiens_hsa046600.86529907
50Cell cycle_Homo sapiens_hsa041100.86113841
51GnRH signaling pathway_Homo sapiens_hsa049120.85992375
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85479593
53Galactose metabolism_Homo sapiens_hsa000520.84980184
54Chemokine signaling pathway_Homo sapiens_hsa040620.82857741
55FoxO signaling pathway_Homo sapiens_hsa040680.82037738
56Regulation of autophagy_Homo sapiens_hsa041400.81615712
57TNF signaling pathway_Homo sapiens_hsa046680.80115784
58Viral myocarditis_Homo sapiens_hsa054160.78703385
59Cholinergic synapse_Homo sapiens_hsa047250.78301071
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77597834
61Acute myeloid leukemia_Homo sapiens_hsa052210.76801398
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76337797
63ABC transporters_Homo sapiens_hsa020100.75593747
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.74542250
65Dorso-ventral axis formation_Homo sapiens_hsa043200.74192399
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.74008198
67Hepatitis C_Homo sapiens_hsa051600.72982429
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70911996
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70392400
70Linoleic acid metabolism_Homo sapiens_hsa005910.68988646
71Pertussis_Homo sapiens_hsa051330.68597636
72MicroRNAs in cancer_Homo sapiens_hsa052060.68351839
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67613089
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.66820865
75Serotonergic synapse_Homo sapiens_hsa047260.65985849
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.64715567
77Alcoholism_Homo sapiens_hsa050340.63308703
78Complement and coagulation cascades_Homo sapiens_hsa046100.62817991
79Prostate cancer_Homo sapiens_hsa052150.62633296
80Bladder cancer_Homo sapiens_hsa052190.62554595
81mRNA surveillance pathway_Homo sapiens_hsa030150.61933904
82Type II diabetes mellitus_Homo sapiens_hsa049300.60062883
83Pancreatic cancer_Homo sapiens_hsa052120.58612727
84Platelet activation_Homo sapiens_hsa046110.58422942
85Nicotine addiction_Homo sapiens_hsa050330.58112950
86Selenocompound metabolism_Homo sapiens_hsa004500.57214714
87HTLV-I infection_Homo sapiens_hsa051660.56943491
88Choline metabolism in cancer_Homo sapiens_hsa052310.55495212
89Viral carcinogenesis_Homo sapiens_hsa052030.55290924
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52200941
91Collecting duct acid secretion_Homo sapiens_hsa049660.51267006
92Antigen processing and presentation_Homo sapiens_hsa046120.50110650
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47624830
94Small cell lung cancer_Homo sapiens_hsa052220.46669319
95Renal cell carcinoma_Homo sapiens_hsa052110.46397728
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46267007
97Basal transcription factors_Homo sapiens_hsa030220.46239261
98Insulin resistance_Homo sapiens_hsa049310.45001752
99Epstein-Barr virus infection_Homo sapiens_hsa051690.44791477
100Ras signaling pathway_Homo sapiens_hsa040140.43220305

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