NRBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)6.91366267
2central nervous system myelination (GO:0022010)5.56134411
3axon ensheathment in central nervous system (GO:0032291)5.56134411
4auditory receptor cell stereocilium organization (GO:0060088)4.27557258
5neuron remodeling (GO:0016322)4.14889137
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.03098789
7positive regulation of neurological system process (GO:0031646)3.83538549
8vocalization behavior (GO:0071625)3.82408980
9postsynaptic membrane organization (GO:0001941)3.64852398
10detection of molecule of bacterial origin (GO:0032490)3.63244677
11myelination (GO:0042552)3.59794012
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.59173313
13ensheathment of neurons (GO:0007272)3.58354879
14axon ensheathment (GO:0008366)3.58354879
15glycine transport (GO:0015816)3.56852104
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.55580451
17semaphorin-plexin signaling pathway (GO:0071526)3.32236899
18negative regulation of neurotransmitter transport (GO:0051589)3.29033670
19fatty acid elongation (GO:0030497)3.22671278
20sodium ion export (GO:0071436)3.21517619
21synaptic vesicle maturation (GO:0016188)3.20258757
22cellular anion homeostasis (GO:0030002)3.17675724
23regulation of synaptic vesicle exocytosis (GO:2000300)3.16399662
24ionotropic glutamate receptor signaling pathway (GO:0035235)3.13434076
25locomotory exploration behavior (GO:0035641)3.10831276
26negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.09411472
27inner ear receptor stereocilium organization (GO:0060122)3.08846721
28positive regulation of synapse maturation (GO:0090129)3.07829839
29sulfate transmembrane transport (GO:1902358)3.06796633
30positive regulation of neurotransmitter secretion (GO:0001956)3.06461237
31neuronal ion channel clustering (GO:0045161)2.99018877
32regulation of glutamate receptor signaling pathway (GO:1900449)2.96959036
33regulation of short-term neuronal synaptic plasticity (GO:0048172)2.95600519
34neurotransmitter-gated ion channel clustering (GO:0072578)2.94914453
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.90872110
36L-amino acid import (GO:0043092)2.90211453
37post-embryonic morphogenesis (GO:0009886)2.90033377
38neuron cell-cell adhesion (GO:0007158)2.89590472
39mannose metabolic process (GO:0006013)2.89171426
40negative regulation of fibrinolysis (GO:0051918)2.88436992
41trivalent inorganic anion homeostasis (GO:0072506)2.85186794
42phosphate ion homeostasis (GO:0055062)2.85186794
43cell-cell junction maintenance (GO:0045217)2.83379079
44dendritic spine morphogenesis (GO:0060997)2.82912809
45neuronal action potential propagation (GO:0019227)2.79511067
46cytoskeletal anchoring at plasma membrane (GO:0007016)2.79328425
47cerebral cortex radially oriented cell migration (GO:0021799)2.74290381
48positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.73724431
49exploration behavior (GO:0035640)2.73694334
50cell migration in hindbrain (GO:0021535)2.73439771
51exogenous drug catabolic process (GO:0042738)2.70854418
52long-chain fatty acid biosynthetic process (GO:0042759)2.70800906
53membrane tubulation (GO:0097320)2.70291199
54amino acid import (GO:0043090)2.70137071
55cerebellar granule cell differentiation (GO:0021707)2.69095473
56apical protein localization (GO:0045176)2.68867880
57axon extension (GO:0048675)2.68689175
58synaptic transmission, glutamatergic (GO:0035249)2.67429645
59establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.66327643
60mitochondrion transport along microtubule (GO:0047497)2.66327643
61peptidyl-tyrosine autophosphorylation (GO:0038083)2.64898989
62glutamate receptor signaling pathway (GO:0007215)2.64613412
63positive regulation of neurotransmitter transport (GO:0051590)2.63715455
64neuromuscular process controlling balance (GO:0050885)2.62354037
65regulation of axon extension involved in axon guidance (GO:0048841)2.61865655
66presynaptic membrane organization (GO:0097090)2.60989454
67regulation of fibrinolysis (GO:0051917)2.60382897
68negative regulation of protein localization to cell surface (GO:2000009)2.60382058
69glutamate secretion (GO:0014047)2.59831200
70cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.59722334
71positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.58194392
72regulation of synapse structural plasticity (GO:0051823)2.58092856
73import into cell (GO:0098657)2.57917478
74bicarbonate transport (GO:0015701)2.57556707
75gamma-aminobutyric acid transport (GO:0015812)2.56953398
76negative regulation of synaptic transmission, GABAergic (GO:0032229)2.56414008
77regulation of plasminogen activation (GO:0010755)2.55766115
78auditory behavior (GO:0031223)2.54527720
79regulation of synapse maturation (GO:0090128)2.52996053
80cell communication by electrical coupling (GO:0010644)2.52890513
81regulation of synaptic vesicle transport (GO:1902803)2.51589941
82transmission of nerve impulse (GO:0019226)2.50331357
83energy homeostasis (GO:0097009)2.50238702
84regulation of ARF protein signal transduction (GO:0032012)2.48799490
85asymmetric protein localization (GO:0008105)2.48447189
86estrogen biosynthetic process (GO:0006703)2.48275612
87neurotransmitter secretion (GO:0007269)2.47867461
88endothelial cell chemotaxis (GO:0035767)2.47421712
89negative regulation of neurotransmitter secretion (GO:0046929)2.46580834
90presynaptic membrane assembly (GO:0097105)2.46394727
91myelination in peripheral nervous system (GO:0022011)2.45093677
92peripheral nervous system axon ensheathment (GO:0032292)2.45093677
93neuron recognition (GO:0008038)2.44463033
94dendritic spine organization (GO:0097061)2.43777534
95G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.42796103
96embryonic retina morphogenesis in camera-type eye (GO:0060059)2.42674194
97neuron-neuron synaptic transmission (GO:0007270)2.42404604
98synaptic vesicle exocytosis (GO:0016079)2.40972821
99adult walking behavior (GO:0007628)2.40373000
100regulation of neuronal synaptic plasticity (GO:0048168)2.40030139
101sulfate transport (GO:0008272)2.37673814
102protein localization to synapse (GO:0035418)2.37357731
103gamma-aminobutyric acid signaling pathway (GO:0007214)2.37346803
104chondroitin sulfate catabolic process (GO:0030207)2.36909008
105establishment of mitochondrion localization (GO:0051654)2.36551443
106response to pheromone (GO:0019236)2.36534966
107layer formation in cerebral cortex (GO:0021819)2.36359602
108proline transport (GO:0015824)2.35599122
109inositol metabolic process (GO:0006020)2.35540340
110cellular potassium ion homeostasis (GO:0030007)2.35448718
111positive regulation of membrane potential (GO:0045838)2.35403319
112negative regulation of synaptic transmission (GO:0050805)2.35383945
113synaptic vesicle endocytosis (GO:0048488)2.35318436
114protein carboxylation (GO:0018214)2.34823355
115peptidyl-glutamic acid carboxylation (GO:0017187)2.34823355
116long term synaptic depression (GO:0060292)2.33869376
117membrane hyperpolarization (GO:0060081)2.33763125
118neuron projection extension (GO:1990138)2.33312877
119regulation of axon guidance (GO:1902667)2.32909718
120positive regulation of dendritic spine development (GO:0060999)2.32424056
121cell junction maintenance (GO:0034331)2.31153505
122axonal fasciculation (GO:0007413)2.30571988
123activation of protein kinase A activity (GO:0034199)2.30351609
124regulation of excitatory postsynaptic membrane potential (GO:0060079)2.29898317
125negative regulation of catenin import into nucleus (GO:0035414)2.29687755
126cerebellar Purkinje cell layer development (GO:0021680)2.29422362
127regulation of ARF GTPase activity (GO:0032312)2.29390890
128cellular sodium ion homeostasis (GO:0006883)2.29181945
129myelin maintenance (GO:0043217)2.27107259
130astrocyte development (GO:0014002)2.26453943
131peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.26298627
132positive regulation of dendrite development (GO:1900006)2.26167806
133camera-type eye morphogenesis (GO:0048593)2.24887055
134dendrite morphogenesis (GO:0048813)2.24528386
135potassium ion homeostasis (GO:0055075)2.24436997
136regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.23217005
137regulation of dendritic spine morphogenesis (GO:0061001)2.22943392
138oligodendrocyte differentiation (GO:0048709)2.22468941
139regulation of voltage-gated calcium channel activity (GO:1901385)2.22433299
140regulation of postsynaptic membrane potential (GO:0060078)2.21793384
141neuromuscular process controlling posture (GO:0050884)2.21776109
142regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.21571472
143dermatan sulfate metabolic process (GO:0030205)2.20597464
144neuron projection regeneration (GO:0031102)2.20303586
145cerebellar Purkinje cell differentiation (GO:0021702)2.17534680
146cell volume homeostasis (GO:0006884)2.16381921
147potassium ion import (GO:0010107)2.16151064
148neuron projection extension involved in neuron projection guidance (GO:1902284)2.15662283
149axon extension involved in axon guidance (GO:0048846)2.15662283
150regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.15326246
151dopamine receptor signaling pathway (GO:0007212)2.14254828
152planar cell polarity pathway involved in neural tube closure (GO:0090179)2.14229940
153positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.13599932
154positive regulation of synapse assembly (GO:0051965)2.13177410
155complement activation, alternative pathway (GO:0006957)2.13128260
156regulation of long-term neuronal synaptic plasticity (GO:0048169)2.13008708
157regulation of axonogenesis (GO:0050770)2.11716065
158response to auditory stimulus (GO:0010996)2.11415754
159positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.11372508
160daunorubicin metabolic process (GO:0044597)10.3718341
161polyketide metabolic process (GO:0030638)10.3718341
162doxorubicin metabolic process (GO:0044598)10.3718341

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.43793855
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.39421744
3GBX2_23144817_ChIP-Seq_PC3_Human3.02736126
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.79710768
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67510675
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67510675
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.67388288
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.66257804
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.52592272
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.44050048
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37623976
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.37213822
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.34893318
14DROSHA_22980978_ChIP-Seq_HELA_Human2.32810145
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28390010
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.27442603
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.26101723
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.22454056
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.19069561
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.15498741
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13871782
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.09758582
23* EZH2_27294783_Chip-Seq_ESCs_Mouse2.09365802
24* KDM2B_26808549_Chip-Seq_K562_Human2.03650597
25* LXR_22292898_ChIP-Seq_THP-1_Human2.01805980
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.93365216
27ZFP281_18757296_ChIP-ChIP_E14_Mouse1.87587692
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86403032
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.81810161
30REST_21632747_ChIP-Seq_MESCs_Mouse1.78434176
31* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.70679173
32AR_21572438_ChIP-Seq_LNCaP_Human1.70197022
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59886045
34ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.54389780
35ZFP281_27345836_Chip-Seq_ESCs_Mouse1.52466121
36RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51252887
37* ERG_21242973_ChIP-ChIP_JURKAT_Human1.50427287
38RARB_27405468_Chip-Seq_BRAIN_Mouse1.47778041
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43171208
40NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.42965159
41* RING1B_27294783_Chip-Seq_ESCs_Mouse1.40703250
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.40290848
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39900510
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.38190295
45* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37853244
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.34341749
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33250371
48SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29983512
49TET1_21490601_ChIP-Seq_MESCs_Mouse1.29312979
50OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.29234027
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28665424
52SMC4_20622854_ChIP-Seq_HELA_Human1.27849999
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.27696348
54KDM2B_26808549_Chip-Seq_DND41_Human1.27639911
55* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26528402
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26336032
57REST_18959480_ChIP-ChIP_MESCs_Mouse1.25532222
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24790825
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24327826
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24309276
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23252583
62RING1B_27294783_Chip-Seq_NPCs_Mouse1.23043137
63RXR_22108803_ChIP-Seq_LS180_Human1.22138573
64TAF15_26573619_Chip-Seq_HEK293_Human1.21963775
65NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20974651
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19855126
67ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19845254
68RACK7_27058665_Chip-Seq_MCF-7_Human1.19545864
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19034527
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18069620
71P300_19829295_ChIP-Seq_ESCs_Human1.16573199
72PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16488459
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16475863
74ELK3_25401928_ChIP-Seq_HUVEC_Human1.16083928
75SMAD4_21799915_ChIP-Seq_A2780_Human1.16048540
76SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15021333
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13448555
78ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12889737
79ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12537495
80CREB1_26743006_Chip-Seq_LNCaP_Human1.12525325
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12322995
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11987909
83KDM2B_26808549_Chip-Seq_JURKAT_Human1.11623281
84EP300_21415370_ChIP-Seq_HL-1_Mouse1.11256579
85RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10982412
86VDR_22108803_ChIP-Seq_LS180_Human1.09626519
87CLOCK_20551151_ChIP-Seq_293T_Human1.09347142
88CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08267793
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08072026
90TP53_23651856_ChIP-Seq_MEFs_Mouse1.07607760
91ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07555838
92RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05270528
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04702438
94DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04317687
95SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03895067
96ESR1_21235772_ChIP-Seq_MCF-7_Human1.03101960
97STAT3_23295773_ChIP-Seq_U87_Human1.02993015
98RXR_22158963_ChIP-Seq_LIVER_Mouse1.02351373
99FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.01117443
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.00697762
101SMAD4_21741376_ChIP-Seq_HESCs_Human1.00578232
102VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99965198
103P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99830067
104P68_20966046_ChIP-Seq_HELA_Human0.99808715
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99456945
106PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99152688
107CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99035287
108SOX2_21211035_ChIP-Seq_LN229_Gbm0.98397255
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98258824
110TP53_20018659_ChIP-ChIP_R1E_Mouse0.97228777
111P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96879199
112* AR_25329375_ChIP-Seq_VCAP_Human0.95589651
113AHR_22903824_ChIP-Seq_MCF-7_Human0.95558536
114TRIM28_21343339_ChIP-Seq_HEK293_Human0.93862621
115SA1_27219007_Chip-Seq_ERYTHROID_Human0.93516816
116RNF2_27304074_Chip-Seq_NSC_Mouse0.93425555
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93184322
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92497376
119NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92324012
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92305758
121DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91621122
122TCF4_23295773_ChIP-Seq_U87_Human0.91003965
123AR_19668381_ChIP-Seq_PC3_Human0.90964799
124TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90941504
125ISL1_27105846_Chip-Seq_CPCs_Mouse0.90438287
126TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90215739
127* TET1_21451524_ChIP-Seq_MESCs_Mouse0.89890130
128MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89739383
129SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89451685
130RUNX2_22187159_ChIP-Seq_PCA_Human0.89308952
131SMAD_19615063_ChIP-ChIP_OVARY_Human0.89254533
132SMAD3_21741376_ChIP-Seq_HESCs_Human0.89236390
133TP63_22573176_ChIP-Seq_HFKS_Human0.88412986
134CTCF_27219007_Chip-Seq_Bcells_Human0.88032637
135SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87929610
136ESR2_21235772_ChIP-Seq_MCF-7_Human0.87875601
137RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87107321
138SMAD4_21741376_ChIP-Seq_EPCs_Human0.87084425
139* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86483137
140MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.86419546
141FOXA2_19822575_ChIP-Seq_HepG2_Human0.85679684
142MYC_27129775_Chip-Seq_CORNEA_Mouse0.85132631
143TBX20_22080862_ChIP-Seq_HEART_Mouse0.84940657
144TBX20_22328084_ChIP-Seq_HEART_Mouse0.84940657
145TP53_16413492_ChIP-PET_HCT116_Human0.84484782
146ER_23166858_ChIP-Seq_MCF-7_Human0.84125151
147TP53_18474530_ChIP-ChIP_U2OS_Human0.84006735
148WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.83594887
149EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.82631044
150YAP1_20516196_ChIP-Seq_MESCs_Mouse0.82487902
151STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.82341466
152TBL1_22424771_ChIP-Seq_293T_Human0.82141158
153ESR1_20079471_ChIP-ChIP_T-47D_Human0.81376089
154TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81297321
155POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.81297321

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology4.16357665
2MP0005377_hearing/vestibular/ear_phenot4.16357665
3MP0004859_abnormal_synaptic_plasticity3.74876044
4MP0008004_abnormal_stomach_pH3.68484258
5MP0003880_abnormal_central_pattern3.66304001
6MP0003705_abnormal_hypodermis_morpholog3.02777621
7MP0005423_abnormal_somatic_nervous2.98254978
8MP0001485_abnormal_pinna_reflex2.73483047
9MP0001486_abnormal_startle_reflex2.60147576
10MP0004742_abnormal_vestibular_system2.53217122
11MP0003879_abnormal_hair_cell2.51828309
12MP0000920_abnormal_myelination2.49234961
13MP0003635_abnormal_synaptic_transmissio2.47058089
14MP0004270_analgesia2.44082868
15MP0005645_abnormal_hypothalamus_physiol2.41202643
16MP0002272_abnormal_nervous_system2.39744606
17MP0009046_muscle_twitch2.38933270
18MP0002064_seizures2.26723127
19MP0004885_abnormal_endolymph2.24957301
20MP0008438_abnormal_cutaneous_collagen2.24138248
21MP0009745_abnormal_behavioral_response2.19615430
22MP0001958_emphysema2.13466335
23MP0005409_darkened_coat_color1.98797357
24MP0002572_abnormal_emotion/affect_behav1.98452953
25MP0009384_cardiac_valve_regurgitation1.95855114
26MP0002734_abnormal_mechanical_nocicepti1.81701200
27MP0001440_abnormal_grooming_behavior1.80832604
28MP0002063_abnormal_learning/memory/cond1.79818744
29MP0003690_abnormal_glial_cell1.79457610
30MP0005360_urolithiasis1.79270908
31MP0001968_abnormal_touch/_nociception1.74077344
32MP0003279_aneurysm1.72912100
33MP0001501_abnormal_sleep_pattern1.69100533
34MP0005503_abnormal_tendon_morphology1.68371626
35MP0000778_abnormal_nervous_system1.67939559
36MP0002735_abnormal_chemical_nociception1.62596101
37MP0004858_abnormal_nervous_system1.61323394
38MP0006276_abnormal_autonomic_nervous1.60909815
39MP0005171_absent_coat_pigmentation1.59628415
40MP0003329_amyloid_beta_deposits1.59584015
41MP0000678_abnormal_parathyroid_gland1.56955843
42MP0001849_ear_inflammation1.54238613
43MP0002184_abnormal_innervation1.49037057
44MP0001970_abnormal_pain_threshold1.48350287
45MP0004924_abnormal_behavior1.47685850
46MP0005386_behavior/neurological_phenoty1.47685850
47MP0005257_abnormal_intraocular_pressure1.46041457
48MP0005646_abnormal_pituitary_gland1.43325430
49MP0002067_abnormal_sensory_capabilities1.41837987
50MP0002557_abnormal_social/conspecific_i1.41835276
51MP0010030_abnormal_orbit_morphology1.41540225
52MP0004043_abnormal_pH_regulation1.37367823
53MP0002733_abnormal_thermal_nociception1.36541299
54MP0003634_abnormal_glial_cell1.35564922
55MP0009780_abnormal_chondrocyte_physiolo1.35337907
56MP0001348_abnormal_lacrimal_gland1.34916222
57MP0000579_abnormal_nail_morphology1.34560277
58MP0003950_abnormal_plasma_membrane1.31473638
59MP0000955_abnormal_spinal_cord1.29768985
60MP0004130_abnormal_muscle_cell1.29392297
61MP0000566_synostosis1.28869541
62MP0010368_abnormal_lymphatic_system1.28709184
63MP0004142_abnormal_muscle_tone1.26313340
64MP0005365_abnormal_bile_salt1.25591051
65MP0008569_lethality_at_weaning1.24816258
66MP0005670_abnormal_white_adipose1.23746558
67MP0003172_abnormal_lysosome_physiology1.23112661
68MP0000003_abnormal_adipose_tissue1.22056052
69MP0004272_abnormal_basement_membrane1.17887167
70MP0002736_abnormal_nociception_after1.15694956
71MP0001529_abnormal_vocalization1.15517938
72MP0002066_abnormal_motor_capabilities/c1.14446451
73MP0001963_abnormal_hearing_physiology1.13511029
74MP0003633_abnormal_nervous_system1.13474045
75MP0002139_abnormal_hepatobiliary_system1.10064750
76MP0005058_abnormal_lysosome_morphology1.09244355
77MP0001502_abnormal_circadian_rhythm1.09121425
78MP0005666_abnormal_adipose_tissue1.08644475
79MP0002229_neurodegeneration1.07705612
80MP0002882_abnormal_neuron_morphology1.05489969
81MP0005375_adipose_tissue_phenotype1.02731036
82MP0003631_nervous_system_phenotype1.02357366
83MP0001664_abnormal_digestion1.01448717
84MP0000534_abnormal_ureter_morphology1.00198314
85MP0005275_abnormal_skin_tensile1.00097432
86MP0003566_abnormal_cell_adhesion1.00089349
87MP0000013_abnormal_adipose_tissue0.99387332
88MP0001177_atelectasis0.99323748
89MP0002089_abnormal_postnatal_growth/wei0.99077347
90MP0002822_catalepsy0.95872484
91MP0006138_congestive_heart_failure0.95631303
92MP0003632_abnormal_nervous_system0.94989878
93MP0004134_abnormal_chest_morphology0.94808101
94MP0004811_abnormal_neuron_physiology0.93790778
95MP0008875_abnormal_xenobiotic_pharmacok0.92567206
96MP0003122_maternal_imprinting0.92395915
97MP0005595_abnormal_vascular_smooth0.89867015
98MP0003091_abnormal_cell_migration0.89671141
99MP0001346_abnormal_lacrimal_gland0.89566742
100MP0008874_decreased_physiological_sensi0.89561441
101MP0003045_fibrosis0.87051576
102MP0000639_abnormal_adrenal_gland0.86552475
103MP0003942_abnormal_urinary_system0.85250389
104MP0000767_abnormal_smooth_muscle0.85139344
105MP0002108_abnormal_muscle_morphology0.81604228
106MP0005023_abnormal_wound_healing0.80900647
107MP0001984_abnormal_olfaction0.80782656
108MP0000026_abnormal_inner_ear0.79870999
109MP0000537_abnormal_urethra_morphology0.79509632
110MP0004233_abnormal_muscle_weight0.78586372
111MP0005167_abnormal_blood-brain_barrier0.77687453
112MP0002796_impaired_skin_barrier0.77515347
113MP0004085_abnormal_heartbeat0.76867906
114MP0002752_abnormal_somatic_nervous0.75420061
115MP0001905_abnormal_dopamine_level0.74582097
116MP0000762_abnormal_tongue_morphology0.74558715
117MP0002069_abnormal_eating/drinking_beha0.74528474
118MP0010678_abnormal_skin_adnexa0.74350352
119MP0002249_abnormal_larynx_morphology0.74055614
120MP0005508_abnormal_skeleton_morphology0.73367991
121MP0000751_myopathy0.72815798
122MP0002971_abnormal_brown_adipose0.72196074
123MP0002116_abnormal_craniofacial_bone0.71489311
124MP0002896_abnormal_bone_mineralization0.71361894
125MP0002152_abnormal_brain_morphology0.70707118
126MP0000462_abnormal_digestive_system0.68220261
127MP0001299_abnormal_eye_distance/0.67840747
128MP0000383_abnormal_hair_follicle0.66305122
129MP0005083_abnormal_biliary_tract0.65595121
130MP0000631_abnormal_neuroendocrine_gland0.65574212
131MP0003075_altered_response_to0.65211193
132MP0004145_abnormal_muscle_electrophysio0.65136237
133MP0005551_abnormal_eye_electrophysiolog0.64978512
134MP0002938_white_spotting0.64596561
135MP0003646_muscle_fatigue0.63999317
136MP0003938_abnormal_ear_development0.63197961
137MP0003136_yellow_coat_color0.62672097
138MP0005623_abnormal_meninges_morphology0.62097627
139MP0001986_abnormal_taste_sensitivity0.58276675
140MP0000467_abnormal_esophagus_morphology0.57709561
141MP0003137_abnormal_impulse_conducting0.56555650
142MP0000604_amyloidosis0.56049181
143MP0009697_abnormal_copulation0.54516048
144MP0005647_abnormal_sex_gland0.54076706

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)8.34341162
2Alopecia of scalp (HP:0002293)5.79528303
3Follicular hyperkeratosis (HP:0007502)5.37970405
4Unilateral renal agenesis (HP:0000122)5.05018736
5Dynein arm defect of respiratory motile cilia (HP:0012255)4.44607886
6Absent/shortened dynein arms (HP:0200106)4.44607886
7Obstructive sleep apnea (HP:0002870)4.42203322
8Bilateral sensorineural hearing impairment (HP:0008619)4.41320861
9Recurrent corneal erosions (HP:0000495)4.26488052
10Abnormality of dental color (HP:0011073)4.14913536
11Myokymia (HP:0002411)4.08127801
12Absent eyelashes (HP:0000561)4.01437115
13Absent eyebrow (HP:0002223)3.90707546
14Neurofibrillary tangles (HP:0002185)3.71241443
15Protrusio acetabuli (HP:0003179)3.66671232
16Focal motor seizures (HP:0011153)3.47097024
17Shallow orbits (HP:0000586)3.41358178
18Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.25261776
19Degeneration of the lateral corticospinal tracts (HP:0002314)3.25261776
20Abolished electroretinogram (ERG) (HP:0000550)3.24340969
21Abnormal ciliary motility (HP:0012262)3.17573850
22Hyperphosphatemia (HP:0002905)3.14978372
23Supranuclear gaze palsy (HP:0000605)3.12041397
24Cervical subluxation (HP:0003308)3.09750825
25Cerebral aneurysm (HP:0004944)3.09039976
26Coronal craniosynostosis (HP:0004440)3.04190780
27Action tremor (HP:0002345)3.02805892
28Premature rupture of membranes (HP:0001788)3.00757320
29Abnormality of the corticospinal tract (HP:0002492)3.00708618
30Broad metatarsal (HP:0001783)2.93782516
31Deep venous thrombosis (HP:0002625)2.89207438
32Erythroderma (HP:0001019)2.85374083
33Cerebral inclusion bodies (HP:0100314)2.81380644
34Bronchomalacia (HP:0002780)2.80138759
35Peripheral hypomyelination (HP:0007182)2.73212604
36Abnormal respiratory motile cilium morphology (HP:0005938)2.70401442
37Abnormal respiratory epithelium morphology (HP:0012253)2.70401442
38Complement deficiency (HP:0004431)2.68722503
39Sleep apnea (HP:0010535)2.68490880
40Onion bulb formation (HP:0003383)2.66102303
41Alacrima (HP:0000522)2.64917995
42Chronic otitis media (HP:0000389)2.63249367
43Metabolic alkalosis (HP:0200114)2.62660537
44Cheilitis (HP:0100825)2.60383835
45Abnormal respiratory motile cilium physiology (HP:0012261)2.59905158
46Intention tremor (HP:0002080)2.59613423
47Ulnar claw (HP:0001178)2.59070971
48Focal seizures (HP:0007359)2.57270757
49Broad face (HP:0000283)2.56275122
50Dysmetria (HP:0001310)2.53137296
51Termporal pattern (HP:0011008)2.49747108
52Insidious onset (HP:0003587)2.49747108
53Tetany (HP:0001281)2.46486733
54Atrophic scars (HP:0001075)2.43931245
55Biconcave vertebral bodies (HP:0004586)2.41636272
56Mitral regurgitation (HP:0001653)2.38331395
57Neonatal short-limb short stature (HP:0008921)2.37899727
58Abnormality of complement system (HP:0005339)2.36835152
59Ankle clonus (HP:0011448)2.36706279
60Stridor (HP:0010307)2.32416000
61Upper limb amyotrophy (HP:0009129)2.32344415
62Distal upper limb amyotrophy (HP:0007149)2.32344415
63Hyperacusis (HP:0010780)2.31130730
64Nuclear cataract (HP:0100018)2.29230111
65Segmental peripheral demyelination/remyelination (HP:0003481)2.28120166
66Bladder diverticulum (HP:0000015)2.27896303
67Scanning speech (HP:0002168)2.27786066
68Vascular tortuosity (HP:0004948)2.26708095
69Arterial tortuosity (HP:0005116)2.26078908
70Spastic gait (HP:0002064)2.25413673
71Aplasia involving bones of the upper limbs (HP:0009823)2.23159139
72Aplasia of the phalanges of the hand (HP:0009802)2.23159139
73Aplasia involving bones of the extremities (HP:0009825)2.23159139
74Abnormality of monocarboxylic acid metabolism (HP:0010996)2.22932450
75Epileptic encephalopathy (HP:0200134)2.17509125
76Ectropion (HP:0000656)2.16636582
77Renal dysplasia (HP:0000110)2.14598570
78Absent hair (HP:0002298)2.14488177
79Progressive cerebellar ataxia (HP:0002073)2.13703443
80Abnormality of calcium-phosphate metabolism (HP:0100530)2.13237254
81Aortic regurgitation (HP:0001659)2.09275824
82Increased circulating renin level (HP:0000848)2.08559344
83Rhinitis (HP:0012384)2.06537390
84Decreased lacrimation (HP:0000633)2.05940629
85Lower limb amyotrophy (HP:0007210)2.05423808
86Bell-shaped thorax (HP:0001591)2.04214424
87Aortic aneurysm (HP:0004942)2.03787941
88J-shaped sella turcica (HP:0002680)2.02559756
89Hyperventilation (HP:0002883)2.02557712
90Corneal erosion (HP:0200020)2.01835021
91Hyperaldosteronism (HP:0000859)2.01169864
92Aortic dissection (HP:0002647)2.00652241
93Thin bony cortex (HP:0002753)1.94946948
94Insomnia (HP:0100785)1.93807376
95Lymphangioma (HP:0100764)1.93609206
96Infantile muscular hypotonia (HP:0008947)1.91110152
97Overgrowth (HP:0001548)1.91040774
98Atonic seizures (HP:0010819)1.89258008
99Joint stiffness (HP:0001387)1.87423314
100Hand muscle atrophy (HP:0009130)1.87312749
101Annular pancreas (HP:0001734)1.87249395
102Spinal rigidity (HP:0003306)1.86972741
103Sensory axonal neuropathy (HP:0003390)1.86863013
104Distal lower limb amyotrophy (HP:0008944)1.86359045
105Abnormal eating behavior (HP:0100738)1.85181219
106Fetal akinesia sequence (HP:0001989)1.83853138
107Foot dorsiflexor weakness (HP:0009027)1.82026328
108Pointed chin (HP:0000307)1.81887722
109Abnormality of renin-angiotensin system (HP:0000847)1.81879299
110Synostosis involving the elbow (HP:0003938)1.81187638
111Humeroradial synostosis (HP:0003041)1.81187638
112Dysdiadochokinesis (HP:0002075)1.80891586
113Akinesia (HP:0002304)1.78291305
114Ulnar bowing (HP:0003031)1.77930634
115Fragile skin (HP:0001030)1.77357128
116Wormian bones (HP:0002645)1.76850072
117Slow saccadic eye movements (HP:0000514)1.76344942
118Limited hip movement (HP:0008800)1.75492974
119Hammertoe (HP:0001765)1.74133081
120Abnormality of dentin (HP:0010299)1.74056128
121Turricephaly (HP:0000262)1.74026254
122Hypoventilation (HP:0002791)1.73256115
123Spinal canal stenosis (HP:0003416)1.72892093
124Retinal dysplasia (HP:0007973)1.72884396
125Hypoplasia of the iris (HP:0007676)1.72678801
126Abnormality of binocular vision (HP:0011514)1.72470426
127Diplopia (HP:0000651)1.72470426
128Thickened helices (HP:0000391)1.72410036
129Mildly elevated creatine phosphokinase (HP:0008180)1.71675463
130Mucopolysacchariduria (HP:0008155)1.71243463
131Urinary glycosaminoglycan excretion (HP:0003541)1.71243463
132Urinary urgency (HP:0000012)1.70749943
133Mitral stenosis (HP:0001718)1.70337223
134Bowel diverticulosis (HP:0005222)1.69893833
135Megalencephaly (HP:0001355)1.69761325
136Abnormal atrioventricular conduction (HP:0005150)1.69457065
137Xanthomatosis (HP:0000991)1.67959009
138Intellectual disability, moderate (HP:0002342)1.67069898
139Disproportionate tall stature (HP:0001519)1.67051644
140Broad-based gait (HP:0002136)1.66396074
141Lower limb muscle weakness (HP:0007340)1.66027017
142Gaze-evoked nystagmus (HP:0000640)1.65276578
143Abnormality of the foot musculature (HP:0001436)1.63944526
144Clumsiness (HP:0002312)1.63886205
145Aneurysm (HP:0002617)1.63540795
146Plagiocephaly (HP:0001357)1.63064203
147Palmoplantar hyperkeratosis (HP:0000972)1.62852304
148Mitral valve prolapse (HP:0001634)1.62607352
149Generalized tonic-clonic seizures (HP:0002069)1.61666599
150Vitreoretinal degeneration (HP:0000655)1.61105757
151Systemic lupus erythematosus (HP:0002725)1.61075023
152Bowing of the arm (HP:0006488)1.60866726
153Bowed forearm bones (HP:0003956)1.60866726
154Hyperactive renin-angiotensin system (HP:0000841)1.60824616
155Steppage gait (HP:0003376)1.60741517
156Abnormality of the ischium (HP:0003174)1.59602524
157Urinary bladder sphincter dysfunction (HP:0002839)1.59072057
158Spastic tetraparesis (HP:0001285)1.58729086
159Hip contracture (HP:0003273)1.58682048
160Neoplasm of the heart (HP:0100544)1.58373278
161Hyperextensible skin (HP:0000974)1.58119023
162Tracheomalacia (HP:0002779)1.57923144
163Decreased motor nerve conduction velocity (HP:0003431)1.57499771
164Renovascular hypertension (HP:0100817)1.56752339
165Dialeptic seizures (HP:0011146)1.56218098
166Increased variability in muscle fiber diameter (HP:0003557)1.56082170
167Abnormality of glycosaminoglycan metabolism (HP:0004371)1.55707137
168Abnormality of mucopolysaccharide metabolism (HP:0011020)1.55707137
169Abnormality of polysaccharide metabolism (HP:0011012)1.55707137
170Widely spaced teeth (HP:0000687)1.55332137
171Postural tremor (HP:0002174)1.54900310
172Conical tooth (HP:0000698)1.54504036
173Torticollis (HP:0000473)1.51609650

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK34.80057312
2SIK14.04693222
3SIK23.94556867
4TRIB33.34192010
5STK392.87516402
6RIPK12.71418723
7EPHA42.50052298
8OXSR12.24269070
9PDGFRA2.22366906
10NTRK32.06803609
11WNK11.90682284
12EPHB11.79694612
13MARK11.76915194
14PRPF4B1.71919415
15NTRK11.68728263
16MARK21.62412798
17MAP3K91.57321488
18PKN11.52636834
19PTK21.51082005
20MAP3K41.49615515
21TNIK1.44963603
22NTRK21.41984520
23ICK1.41519578
24FGFR21.40104142
25PAK61.39954168
26MARK31.34967689
27DAPK21.33378418
28DDR21.32753946
29PHKG11.32474360
30PHKG21.32474360
31UHMK11.32295164
32SGK2231.29464853
33SGK4941.29464853
34CSNK1A1L1.29244146
35LATS11.25904599
36MAPKAPK51.25674405
37WNK41.25640098
38LATS21.25374251
39MAPK121.24454645
40MAP2K41.21136507
41EPHB21.17461819
42MAPK151.16691925
43EPHA21.16320002
44RPS6KA21.16126903
45CASK1.14262004
46PRKD31.10990542
47MAP2K61.09561636
48FGFR41.08956499
49TYRO31.08108758
50CSNK1G21.07824792
51CSNK1G31.07499090
52PNCK1.07486306
53PDGFRB1.06700188
54STK381.05551306
55FGR1.03898487
56CAMK2B1.03896891
57CDK191.02295889
58ERN11.00619085
59MAPK131.00311827
60ERBB21.00196241
61CDK50.99118936
62MAP3K120.98534085
63MAP2K70.96441587
64INSRR0.95470757
65BCR0.92967868
66EEF2K0.92150724
67DMPK0.91263438
68CSNK1G10.89606544
69MET0.89601713
70CAMK2A0.88241195
71MINK10.87842314
72PAK40.87354143
73CAMK2G0.87054794
74TTN0.85990041
75CAMK10.85297683
76PINK10.85215554
77CAMK2D0.82518164
78PAK30.82318115
79MAP2K30.81887942
80CAMK1G0.81756699
81MTOR0.79697874
82ROCK20.79006074
83ARAF0.78654282
84PKN20.73221849
85NEK60.71324074
86ROCK10.70592898
87PAK20.68564738
88TESK10.67881428
89PRKCH0.66089306
90LIMK10.65068789
91MYLK0.63745757
92CSNK1D0.62674543
93MOS0.61909581
94MAPK100.60240991
95MAPK70.59634221
96FER0.59553160
97TNK20.58752286
98STK110.58697112
99PRKCE0.58352165
100MAP3K20.57268610
101PRKD10.54020743
102KSR20.53760941
103SGK10.53300743
104CDK11A0.52186806
105SGK20.51851714
106ADRBK20.51635849
107DYRK1B0.51333724
108CDC42BPA0.51247095
109PRKCG0.50695811
110GRK50.50537748
111PRKG10.50155185
112CAMK40.48643112
113SGK30.48359780
114TRPM70.47898449
115PTK60.47601672
116FYN0.46988205
117PRKCZ0.46223283
118MST1R0.46086290
119PTK2B0.45577131
120LMTK20.44852168
121RET0.44823055
122PDPK10.44270295
123EPHA30.43977348
124MAP3K60.43238106
125MAPK80.42980079
126MAP3K70.39378862
127BMX0.39116551
128CDK150.38486172
129CDK140.38311238
130CAMKK10.37167129
131DYRK1A0.36842047
132PRKD20.35762378
133MAP3K130.34785513
134CDK180.34152261

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.64789952
2Nitrogen metabolism_Homo sapiens_hsa009102.25953492
3GABAergic synapse_Homo sapiens_hsa047272.24053613
4Glutamatergic synapse_Homo sapiens_hsa047242.00528553
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.97172551
6Synaptic vesicle cycle_Homo sapiens_hsa047211.94627249
7Axon guidance_Homo sapiens_hsa043601.93848967
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.91724120
9Fatty acid elongation_Homo sapiens_hsa000621.86799952
10Morphine addiction_Homo sapiens_hsa050321.85418029
11Circadian entrainment_Homo sapiens_hsa047131.84972603
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.77550385
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.71505282
14Steroid biosynthesis_Homo sapiens_hsa001001.68193965
15Complement and coagulation cascades_Homo sapiens_hsa046101.63880112
16Prion diseases_Homo sapiens_hsa050201.61220438
17Gastric acid secretion_Homo sapiens_hsa049711.57378190
18Mineral absorption_Homo sapiens_hsa049781.56767625
19Salivary secretion_Homo sapiens_hsa049701.51233505
20Serotonergic synapse_Homo sapiens_hsa047261.45842787
21Taste transduction_Homo sapiens_hsa047421.44106975
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.40472525
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38989353
24Long-term depression_Homo sapiens_hsa047301.32387150
25Calcium signaling pathway_Homo sapiens_hsa040201.30261849
26Olfactory transduction_Homo sapiens_hsa047401.29600459
27Insulin secretion_Homo sapiens_hsa049111.28031453
28Amphetamine addiction_Homo sapiens_hsa050311.27315086
29Cocaine addiction_Homo sapiens_hsa050301.25941206
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.24914354
31Arginine biosynthesis_Homo sapiens_hsa002201.22577966
32Notch signaling pathway_Homo sapiens_hsa043301.21753081
33Butanoate metabolism_Homo sapiens_hsa006501.21607480
34Dopaminergic synapse_Homo sapiens_hsa047281.21091907
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.20016244
36Fatty acid biosynthesis_Homo sapiens_hsa000611.19709043
37Long-term potentiation_Homo sapiens_hsa047201.19058364
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18928281
39Ovarian steroidogenesis_Homo sapiens_hsa049131.18483138
40Renin secretion_Homo sapiens_hsa049241.17941246
41Cholinergic synapse_Homo sapiens_hsa047251.17104612
42VEGF signaling pathway_Homo sapiens_hsa043701.16211675
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15869284
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.12730002
45Focal adhesion_Homo sapiens_hsa045101.11429716
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08944752
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07647114
48Other glycan degradation_Homo sapiens_hsa005111.06232532
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02947171
50Ether lipid metabolism_Homo sapiens_hsa005651.02633431
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.01078064
52Phenylalanine metabolism_Homo sapiens_hsa003600.99891477
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98291624
54Glioma_Homo sapiens_hsa052140.97018950
55ABC transporters_Homo sapiens_hsa020100.95511772
56cAMP signaling pathway_Homo sapiens_hsa040240.94614620
57ErbB signaling pathway_Homo sapiens_hsa040120.94604281
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94460604
59Type II diabetes mellitus_Homo sapiens_hsa049300.92872983
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91831307
61Bile secretion_Homo sapiens_hsa049760.90453343
62Renal cell carcinoma_Homo sapiens_hsa052110.90402917
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.89611206
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.89468168
65Oxytocin signaling pathway_Homo sapiens_hsa049210.87034049
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86710922
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85638254
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85407139
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82252090
70Fatty acid metabolism_Homo sapiens_hsa012120.80241554
71Sulfur metabolism_Homo sapiens_hsa009200.79785293
72Pancreatic secretion_Homo sapiens_hsa049720.79763801
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79020096
74Dorso-ventral axis formation_Homo sapiens_hsa043200.78746627
75Gap junction_Homo sapiens_hsa045400.77827085
76Ras signaling pathway_Homo sapiens_hsa040140.77059027
77AMPK signaling pathway_Homo sapiens_hsa041520.76325963
78GnRH signaling pathway_Homo sapiens_hsa049120.76170965
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75951209
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.75427265
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75127721
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74389210
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74115239
84Fatty acid degradation_Homo sapiens_hsa000710.73383635
85Amoebiasis_Homo sapiens_hsa051460.72801268
86Tyrosine metabolism_Homo sapiens_hsa003500.72432226
87Dilated cardiomyopathy_Homo sapiens_hsa054140.70849214
88Arginine and proline metabolism_Homo sapiens_hsa003300.70609104
89Insulin signaling pathway_Homo sapiens_hsa049100.69371890
90Glucagon signaling pathway_Homo sapiens_hsa049220.69309362
91Chemical carcinogenesis_Homo sapiens_hsa052040.68818626
92Histidine metabolism_Homo sapiens_hsa003400.67442403
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66333687
94Cardiac muscle contraction_Homo sapiens_hsa042600.66236221
95Hedgehog signaling pathway_Homo sapiens_hsa043400.65091032
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.64940819
97Melanogenesis_Homo sapiens_hsa049160.63323045
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62656742
99Estrogen signaling pathway_Homo sapiens_hsa049150.62383627
100Thyroid hormone synthesis_Homo sapiens_hsa049180.61032908
101Retinol metabolism_Homo sapiens_hsa008300.60994565
102Tight junction_Homo sapiens_hsa045300.60276077
103Choline metabolism in cancer_Homo sapiens_hsa052310.60198269
104Protein digestion and absorption_Homo sapiens_hsa049740.60029023
105Wnt signaling pathway_Homo sapiens_hsa043100.59619554
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58982972
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58418585
108Circadian rhythm_Homo sapiens_hsa047100.58376881
109Vitamin B6 metabolism_Homo sapiens_hsa007500.58236055
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57712993
111Hippo signaling pathway_Homo sapiens_hsa043900.56915178
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56772286
113Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55490979
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.55372407
115Sphingolipid metabolism_Homo sapiens_hsa006000.54014653
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53641121
117Proteoglycans in cancer_Homo sapiens_hsa052050.53401747
118Inositol phosphate metabolism_Homo sapiens_hsa005620.53296763
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52858737
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.52738865
121Lysine degradation_Homo sapiens_hsa003100.52695177
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52592196
123Collecting duct acid secretion_Homo sapiens_hsa049660.52447507
124MAPK signaling pathway_Homo sapiens_hsa040100.52131053
125beta-Alanine metabolism_Homo sapiens_hsa004100.51376254
126alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49911039
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.49889796
128Rap1 signaling pathway_Homo sapiens_hsa040150.49642325
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49259441
130Endometrial cancer_Homo sapiens_hsa052130.48977377
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48309020
132PPAR signaling pathway_Homo sapiens_hsa033200.48129789
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.47452475
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46067022
135Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45189188
136ECM-receptor interaction_Homo sapiens_hsa045120.44369129
137Glycerolipid metabolism_Homo sapiens_hsa005610.43023227
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41802219

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