NRCAM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.07536831
2locomotory exploration behavior (GO:0035641)5.74800299
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.41644288
4synaptic vesicle maturation (GO:0016188)5.35949760
5vocalization behavior (GO:0071625)5.32272591
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.26613546
7synaptic vesicle exocytosis (GO:0016079)5.22976873
8glutamate secretion (GO:0014047)5.15532813
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.06870765
10neuron cell-cell adhesion (GO:0007158)4.90051518
11regulation of glutamate receptor signaling pathway (GO:1900449)4.87987963
12protein localization to synapse (GO:0035418)4.84904177
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.77241344
14dendritic spine morphogenesis (GO:0060997)4.69437357
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.67413537
16regulation of synaptic vesicle exocytosis (GO:2000300)4.66309486
17exploration behavior (GO:0035640)4.58420064
18regulation of long-term neuronal synaptic plasticity (GO:0048169)4.53597308
19synaptic transmission, glutamatergic (GO:0035249)4.45981311
20regulation of neuronal synaptic plasticity (GO:0048168)4.43790378
21glutamate receptor signaling pathway (GO:0007215)4.40372311
22layer formation in cerebral cortex (GO:0021819)4.33642762
23neurotransmitter-gated ion channel clustering (GO:0072578)4.32779384
24neurotransmitter secretion (GO:0007269)4.19960867
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.15647045
26regulation of synaptic vesicle transport (GO:1902803)4.15080239
27neuron-neuron synaptic transmission (GO:0007270)4.09906349
28regulation of synapse structural plasticity (GO:0051823)4.01237586
29proline transport (GO:0015824)3.96652766
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.94259652
31gamma-aminobutyric acid transport (GO:0015812)3.88593478
32cellular potassium ion homeostasis (GO:0030007)3.88481399
33* neuron recognition (GO:0008038)3.88285606
34long-term memory (GO:0007616)3.84827456
35amino acid import (GO:0043090)3.81889150
36pyrimidine nucleobase catabolic process (GO:0006208)3.80610895
37innervation (GO:0060384)3.78586301
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.71204506
39* axonal fasciculation (GO:0007413)3.65746054
40postsynaptic membrane organization (GO:0001941)3.61882501
41positive regulation of synapse maturation (GO:0090129)3.60075853
42* neuronal action potential propagation (GO:0019227)3.60052663
43regulation of postsynaptic membrane potential (GO:0060078)3.58310988
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.57434151
45G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.56436237
46positive regulation of membrane potential (GO:0045838)3.55098676
47regulation of synaptic plasticity (GO:0048167)3.54595773
48transmission of nerve impulse (GO:0019226)3.48962268
49sodium ion export (GO:0071436)3.48137429
50regulation of dendritic spine morphogenesis (GO:0061001)3.44839356
51dendrite morphogenesis (GO:0048813)3.44738001
52neurotransmitter transport (GO:0006836)3.44251888
53axon ensheathment in central nervous system (GO:0032291)3.43489749
54central nervous system myelination (GO:0022010)3.43489749
55synaptic vesicle endocytosis (GO:0048488)3.42832653
56gamma-aminobutyric acid signaling pathway (GO:0007214)3.41104175
57long-term synaptic potentiation (GO:0060291)3.40326765
58response to auditory stimulus (GO:0010996)3.39397763
59positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.39243914
60acidic amino acid transport (GO:0015800)3.38351461
61negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.37678085
62regulation of synaptic transmission, glutamatergic (GO:0051966)3.36816455
63dendritic spine organization (GO:0097061)3.36694599
64auditory behavior (GO:0031223)3.35905018
65establishment of mitochondrion localization (GO:0051654)3.34536005
66positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.33415954
67presynaptic membrane assembly (GO:0097105)3.33336653
68central nervous system projection neuron axonogenesis (GO:0021952)3.27552799
69potassium ion homeostasis (GO:0055075)3.23404694
70regulation of neurotransmitter secretion (GO:0046928)3.22825750
71neuromuscular process controlling balance (GO:0050885)3.21242579
72nucleobase catabolic process (GO:0046113)3.21206822
73cell communication by electrical coupling (GO:0010644)3.19978893
74neurotransmitter uptake (GO:0001504)3.18979643
75regulation of vesicle fusion (GO:0031338)3.18813593
76regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.16975113
77cerebellar granule cell differentiation (GO:0021707)3.16432112
78C4-dicarboxylate transport (GO:0015740)3.16389243
79cerebellar Purkinje cell differentiation (GO:0021702)3.16066058
80response to histamine (GO:0034776)3.15958172
81negative regulation of synaptic transmission, GABAergic (GO:0032229)3.15082398
82activation of protein kinase A activity (GO:0034199)3.14942381
83regulation of neurotransmitter levels (GO:0001505)3.14357312
84cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.13809207
85regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.13485924
86* neuronal ion channel clustering (GO:0045161)3.09735441
87cellular sodium ion homeostasis (GO:0006883)3.09366443
88establishment of nucleus localization (GO:0040023)3.09028718
89behavioral defense response (GO:0002209)3.08509266
90behavioral fear response (GO:0001662)3.08509266
91G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.08232375
92learning (GO:0007612)3.05450498
93L-amino acid import (GO:0043092)3.05176936
94positive regulation of dendritic spine development (GO:0060999)3.04998649
95presynaptic membrane organization (GO:0097090)3.04947195
96neuromuscular synaptic transmission (GO:0007274)3.04910857
97startle response (GO:0001964)3.04896385
98potassium ion import (GO:0010107)3.03866032
99positive regulation of synaptic transmission, GABAergic (GO:0032230)3.03713765
100membrane depolarization (GO:0051899)3.03567203
101L-glutamate transport (GO:0015813)3.03328831
102positive regulation of neurotransmitter secretion (GO:0001956)3.02452657
103membrane depolarization during action potential (GO:0086010)3.00429580
104regulation of dendritic spine development (GO:0060998)2.99660954
105cell migration in hindbrain (GO:0021535)2.98830695
106positive regulation of dendritic spine morphogenesis (GO:0061003)2.97838972
107regulation of neurotransmitter transport (GO:0051588)2.96462389
108membrane hyperpolarization (GO:0060081)2.95856765
109negative regulation of dendrite development (GO:2000171)2.95369297
110fear response (GO:0042596)2.93103319
111* synapse assembly (GO:0007416)2.92767037
112regulation of synaptic transmission (GO:0050804)2.92356680
113positive regulation of synapse assembly (GO:0051965)2.89605815
114mechanosensory behavior (GO:0007638)2.88070295
115positive regulation of synaptic transmission (GO:0050806)2.87486134
116cerebellar Purkinje cell layer development (GO:0021680)2.86973606
117detection of calcium ion (GO:0005513)2.86056800
118positive regulation of neurotransmitter transport (GO:0051590)2.85606172
119synaptic transmission (GO:0007268)2.84422327
120negative regulation of dendrite morphogenesis (GO:0050774)2.84267777
121regulation of respiratory system process (GO:0044065)2.83923305
122* synapse organization (GO:0050808)2.83377052
123adult walking behavior (GO:0007628)2.83367671

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.06104722
2GBX2_23144817_ChIP-Seq_PC3_Human3.73598643
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19018130
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.14674673
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.13350101
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80732797
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80732797
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.70088285
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.69468247
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.69436210
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.62015508
12* REST_21632747_ChIP-Seq_MESCs_Mouse2.59711818
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.57359399
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52322779
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50016844
16DROSHA_22980978_ChIP-Seq_HELA_Human2.45570114
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44635170
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.34500689
19* RNF2_27304074_Chip-Seq_ESCs_Mouse2.31158188
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24933254
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.21217842
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.15856013
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.11505402
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.07953076
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.99922892
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98101510
27AR_21572438_ChIP-Seq_LNCaP_Human1.97820882
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93332834
29TAF15_26573619_Chip-Seq_HEK293_Human1.84623552
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83642956
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83150748
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70975783
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68331586
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.67367754
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67257141
36* SMAD4_21799915_ChIP-Seq_A2780_Human1.65768889
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62143721
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59842701
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58020793
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57473642
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56280219
42P300_19829295_ChIP-Seq_ESCs_Human1.50668396
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.42044652
44NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40449627
45* RING1B_27294783_Chip-Seq_ESCs_Mouse1.38745320
46ZNF274_21170338_ChIP-Seq_K562_Hela1.38447496
47RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.38114921
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.37871904
49SOX2_21211035_ChIP-Seq_LN229_Gbm1.36623017
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36257176
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.35567716
52AR_25329375_ChIP-Seq_VCAP_Human1.33422029
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29336243
54* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25407002
55STAT3_23295773_ChIP-Seq_U87_Human1.24752889
56* AR_19668381_ChIP-Seq_PC3_Human1.24171467
57* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23840013
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22386564
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22321099
60* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21354491
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.20342287
62IGF1R_20145208_ChIP-Seq_DFB_Human1.19738415
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17980012
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17914510
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17188690
66* ARNT_22903824_ChIP-Seq_MCF-7_Human1.16781090
67* RING1B_27294783_Chip-Seq_NPCs_Mouse1.16722590
68* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15334434
69* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14461575
70TP53_16413492_ChIP-PET_HCT116_Human1.14392775
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12742796
72* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12062943
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.11800315
74LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10793125
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07923806
76RNF2_27304074_Chip-Seq_NSC_Mouse1.06873228
77STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06136415
78* TCF4_23295773_ChIP-Seq_U87_Human1.06045200
79DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06015004
80P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05344011
81KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04757871
82FUS_26573619_Chip-Seq_HEK293_Human1.04613583
83WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04528857
84* AHR_22903824_ChIP-Seq_MCF-7_Human1.03710529
85* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02270629
86RUNX2_22187159_ChIP-Seq_PCA_Human1.02160383
87MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01515050
88SOX9_26525672_Chip-Seq_HEART_Mouse1.00943620
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00786757
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00786757
91* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00318668
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99315568
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98504071
94OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98075248
95PRDM14_20953172_ChIP-Seq_ESCs_Human0.95903221
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95730559
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95312844
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95144635
99* SMAD3_21741376_ChIP-Seq_ESCs_Human0.94652499
100TP53_18474530_ChIP-ChIP_U2OS_Human0.93963606
101FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93505461
102KDM2B_26808549_Chip-Seq_REH_Human0.93388792
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92856112
104JUN_21703547_ChIP-Seq_K562_Human0.92176831
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92141173
106ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92092723
107* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91932060
108SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91766502
109P53_22387025_ChIP-Seq_ESCs_Mouse0.91437464
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90192391
111TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90148246
112* SMAD4_21741376_ChIP-Seq_HESCs_Human0.89823182
113KDM2B_26808549_Chip-Seq_K562_Human0.89795788
114* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89015009
115BCAT_22108803_ChIP-Seq_LS180_Human0.89007045
116* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88743925

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.44339747
2MP0003880_abnormal_central_pattern4.84916654
3* MP0003635_abnormal_synaptic_transmissio4.07019588
4MP0004270_analgesia3.62600484
5MP0009745_abnormal_behavioral_response3.31594299
6* MP0002063_abnormal_learning/memory/cond3.28928454
7MP0002064_seizures3.05989695
8MP0009046_muscle_twitch2.89264697
9MP0001968_abnormal_touch/_nociception2.88359815
10MP0005423_abnormal_somatic_nervous2.85677248
11MP0002572_abnormal_emotion/affect_behav2.76602157
12MP0001486_abnormal_startle_reflex2.57847404
13MP0002734_abnormal_mechanical_nocicepti2.52572585
14* MP0002272_abnormal_nervous_system2.38500565
15MP0000778_abnormal_nervous_system2.25956978
16MP0002736_abnormal_nociception_after2.20662790
17MP0002735_abnormal_chemical_nociception2.10625009
18MP0001501_abnormal_sleep_pattern2.08677884
19MP0001440_abnormal_grooming_behavior2.07272908
20MP0002822_catalepsy2.01825800
21MP0002067_abnormal_sensory_capabilities2.00616483
22MP0002184_abnormal_innervation1.98914714
23MP0004858_abnormal_nervous_system1.94562788
24MP0009780_abnormal_chondrocyte_physiolo1.94208241
25MP0003329_amyloid_beta_deposits1.89179651
26MP0002733_abnormal_thermal_nociception1.85259280
27MP0008569_lethality_at_weaning1.79619857
28MP0001970_abnormal_pain_threshold1.76283131
29* MP0002557_abnormal_social/conspecific_i1.74590535
30MP0004924_abnormal_behavior1.74017152
31MP0005386_behavior/neurological_phenoty1.74017152
32MP0004811_abnormal_neuron_physiology1.70872073
33MP0000955_abnormal_spinal_cord1.70411796
34MP0005646_abnormal_pituitary_gland1.70063066
35MP0004885_abnormal_endolymph1.61676392
36MP0006276_abnormal_autonomic_nervous1.55291831
37MP0003879_abnormal_hair_cell1.54753299
38MP0002909_abnormal_adrenal_gland1.53461053
39MP0001984_abnormal_olfaction1.50698346
40* MP0002882_abnormal_neuron_morphology1.50099944
41MP0003121_genomic_imprinting1.38743887
42* MP0002066_abnormal_motor_capabilities/c1.38268015
43MP0003123_paternal_imprinting1.37395959
44MP0000569_abnormal_digit_pigmentation1.37146593
45MP0001529_abnormal_vocalization1.36731803
46MP0001502_abnormal_circadian_rhythm1.28673412
47MP0003633_abnormal_nervous_system1.27027421
48MP0003283_abnormal_digestive_organ1.26552889
49MP0005171_absent_coat_pigmentation1.23225280
50MP0004142_abnormal_muscle_tone1.22697735
51MP0005645_abnormal_hypothalamus_physiol1.22151648
52* MP0002152_abnormal_brain_morphology1.21005760
53MP0001905_abnormal_dopamine_level1.17692736
54MP0003122_maternal_imprinting1.17579606
55MP0004742_abnormal_vestibular_system1.16878905
56MP0003787_abnormal_imprinting1.16342804
57MP0003631_nervous_system_phenotype1.09169840
58MP0001188_hyperpigmentation1.09076738
59MP0005551_abnormal_eye_electrophysiolog1.03387385
60MP0003634_abnormal_glial_cell1.02481167
61MP0004145_abnormal_muscle_electrophysio1.00059080
62MP0000631_abnormal_neuroendocrine_gland0.98982972
63MP0001963_abnormal_hearing_physiology0.96930875
64MP0005394_taste/olfaction_phenotype0.94509510
65MP0005499_abnormal_olfactory_system0.94509510
66MP0000751_myopathy0.90500806
67MP0003690_abnormal_glial_cell0.89224726
68MP0002229_neurodegeneration0.88770171
69MP0008872_abnormal_physiological_respon0.88347418
70MP0001485_abnormal_pinna_reflex0.88321282
71MP0002752_abnormal_somatic_nervous0.87780768
72MP0002069_abnormal_eating/drinking_beha0.86172625
73MP0005187_abnormal_penis_morphology0.84409642
74MP0002102_abnormal_ear_morphology0.83990982
75MP0003632_abnormal_nervous_system0.83002202
76MP0000026_abnormal_inner_ear0.82497299
77MP0002638_abnormal_pupillary_reflex0.82076938
78MP0001177_atelectasis0.81222665
79MP0002090_abnormal_vision0.81089524
80MP0001299_abnormal_eye_distance/0.79579205
81MP0003137_abnormal_impulse_conducting0.79459696
82MP0003861_abnormal_nervous_system0.77511801
83MP0005167_abnormal_blood-brain_barrier0.76132224
84MP0000604_amyloidosis0.75706778
85MP0004215_abnormal_myocardial_fiber0.74493452
86MP0010386_abnormal_urinary_bladder0.73721804
87MP0004233_abnormal_muscle_weight0.73527939
88MP0005248_abnormal_Harderian_gland0.72864617
89MP0004085_abnormal_heartbeat0.72380621
90MP0008877_abnormal_DNA_methylation0.70225397
91MP0002837_dystrophic_cardiac_calcinosis0.69644517
92MP0008874_decreased_physiological_sensi0.67089017
93MP0008961_abnormal_basal_metabolism0.66508860
94MP0004133_heterotaxia0.66441992
95MP0000920_abnormal_myelination0.65810784
96MP0003075_altered_response_to0.63486843
97MP0003172_abnormal_lysosome_physiology0.63433947
98MP0010770_preweaning_lethality0.62104511
99MP0002082_postnatal_lethality0.62104511
100MP0001943_abnormal_respiration0.62088313
101MP0010769_abnormal_survival0.61999346
102MP0001986_abnormal_taste_sensitivity0.61880809
103MP0002234_abnormal_pharynx_morphology0.59791315
104MP0000579_abnormal_nail_morphology0.59506050
105MP0002751_abnormal_autonomic_nervous0.59472112
106MP0000534_abnormal_ureter_morphology0.59312102
107MP0005623_abnormal_meninges_morphology0.59085631
108MP0010768_mortality/aging0.58875148
109MP0002653_abnormal_ependyma_morphology0.58708432
110MP0006292_abnormal_olfactory_placode0.58626614
111MP0005253_abnormal_eye_physiology0.58552208
112MP0005535_abnormal_body_temperature0.58547930
113MP0003938_abnormal_ear_development0.58508447
114MP0006072_abnormal_retinal_apoptosis0.58231167
115MP0003119_abnormal_digestive_system0.55721537
116MP0000462_abnormal_digestive_system0.55045141
117MP0002081_perinatal_lethality0.52970032
118MP0000639_abnormal_adrenal_gland0.52869387

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.42306654
2Myokymia (HP:0002411)6.16023280
3Focal seizures (HP:0007359)5.65641916
4Epileptic encephalopathy (HP:0200134)4.91560224
5Visual hallucinations (HP:0002367)4.74069225
6Progressive cerebellar ataxia (HP:0002073)4.22422429
7Atonic seizures (HP:0010819)4.13527740
8Febrile seizures (HP:0002373)4.07266952
9Absence seizures (HP:0002121)3.90319964
10Dialeptic seizures (HP:0011146)3.61844654
11Generalized tonic-clonic seizures (HP:0002069)3.61830404
12Supranuclear gaze palsy (HP:0000605)3.56848511
13Action tremor (HP:0002345)3.56816516
14Broad-based gait (HP:0002136)3.56371631
15Hyperventilation (HP:0002883)3.46853479
16Amblyopia (HP:0000646)3.11194235
17Impaired vibration sensation in the lower limbs (HP:0002166)3.10849558
18Poor eye contact (HP:0000817)3.10226168
19Ankle clonus (HP:0011448)3.06099225
20Truncal ataxia (HP:0002078)2.96729885
21Gaze-evoked nystagmus (HP:0000640)2.95298454
22Megalencephaly (HP:0001355)2.94985497
23Dysdiadochokinesis (HP:0002075)2.94023986
24Drooling (HP:0002307)2.92354574
25Excessive salivation (HP:0003781)2.92354574
26Depression (HP:0000716)2.89329730
27Papilledema (HP:0001085)2.88695001
28Hemiparesis (HP:0001269)2.86251607
29Mutism (HP:0002300)2.82429169
30Blue irides (HP:0000635)2.81099336
31Impaired social interactions (HP:0000735)2.79915102
32Abnormal social behavior (HP:0012433)2.79915102
33Neurofibrillary tangles (HP:0002185)2.79437871
34Abnormal eating behavior (HP:0100738)2.76932280
35Cerebral inclusion bodies (HP:0100314)2.75119187
36Diplopia (HP:0000651)2.75013553
37Abnormality of binocular vision (HP:0011514)2.75013553
38Urinary bladder sphincter dysfunction (HP:0002839)2.74965142
39Dysmetria (HP:0001310)2.74725817
40Postural instability (HP:0002172)2.65249248
41Split foot (HP:0001839)2.61351977
42Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.58964240
43Degeneration of the lateral corticospinal tracts (HP:0002314)2.58964240
44Epileptiform EEG discharges (HP:0011182)2.57106791
45Genetic anticipation (HP:0003743)2.55280836
46Scanning speech (HP:0002168)2.54425979
47Urinary urgency (HP:0000012)2.51296194
48Anxiety (HP:0000739)2.49162930
49Impaired smooth pursuit (HP:0007772)2.48943551
50EEG with generalized epileptiform discharges (HP:0011198)2.44348196
51Stereotypic behavior (HP:0000733)2.43724065
52Hemiplegia (HP:0002301)2.32965873
53Progressive inability to walk (HP:0002505)2.32264254
54Hypsarrhythmia (HP:0002521)2.31411829
55Abnormality of the lower motor neuron (HP:0002366)2.30284512
56Fetal akinesia sequence (HP:0001989)2.28969310
57Absent speech (HP:0001344)2.27064435
58Peripheral hypomyelination (HP:0007182)2.26691463
59Spastic gait (HP:0002064)2.26562338
60Termporal pattern (HP:0011008)2.24614168
61Insidious onset (HP:0003587)2.24614168
62Polyphagia (HP:0002591)2.24084321
63Abnormality of the corticospinal tract (HP:0002492)2.24032074
64Intention tremor (HP:0002080)2.22012110
65Sleep apnea (HP:0010535)2.21437779
66Torticollis (HP:0000473)2.19640683
67Abnormality of ocular smooth pursuit (HP:0000617)2.18751602
68Bradykinesia (HP:0002067)2.18581716
69Lower limb muscle weakness (HP:0007340)2.14728574
70Aplasia involving bones of the upper limbs (HP:0009823)2.12562694
71Aplasia of the phalanges of the hand (HP:0009802)2.12562694
72Aplasia involving bones of the extremities (HP:0009825)2.12562694
73Impaired vibratory sensation (HP:0002495)2.11325527
74Amyotrophic lateral sclerosis (HP:0007354)2.10280200
75Limb dystonia (HP:0002451)2.09857718
76Inability to walk (HP:0002540)2.07597196
77Generalized hypopigmentation of hair (HP:0011358)2.07382555
78Morphological abnormality of the pyramidal tract (HP:0002062)2.04333542
79Status epilepticus (HP:0002133)2.03861912
80Focal dystonia (HP:0004373)2.03808260
81Abnormality of salivation (HP:0100755)1.95452740
82Incomplete penetrance (HP:0003829)1.95378398
83Ankyloglossia (HP:0010296)1.94173948
84Gait imbalance (HP:0002141)1.92049111
85Pointed chin (HP:0000307)1.91743543
86Protruding tongue (HP:0010808)1.90405148
87Specific learning disability (HP:0001328)1.90116754
88Aqueductal stenosis (HP:0002410)1.89539463
89Spastic tetraplegia (HP:0002510)1.89442362
90Increased circulating renin level (HP:0000848)1.88776338
91Generalized myoclonic seizures (HP:0002123)1.88606510
92Agitation (HP:0000713)1.88188809
93Hypoplasia of the corpus callosum (HP:0002079)1.86698121
94Apathy (HP:0000741)1.86100759
95Inappropriate behavior (HP:0000719)1.84898872
96Congenital primary aphakia (HP:0007707)1.84491968
97Obstructive sleep apnea (HP:0002870)1.84065928
98Pheochromocytoma (HP:0002666)1.81271931
99Gait ataxia (HP:0002066)1.79355768
100Vaginal atresia (HP:0000148)1.78250769
101Akinesia (HP:0002304)1.77751369
102Narrow nasal bridge (HP:0000446)1.77266613
103Clonus (HP:0002169)1.76926250
104Neuroendocrine neoplasm (HP:0100634)1.76810082
105Genital tract atresia (HP:0001827)1.76709451
106Cutaneous finger syndactyly (HP:0010554)1.76153493
107Craniofacial dystonia (HP:0012179)1.73363883
108Anosmia (HP:0000458)1.72720739
109Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.72318939
110Nephrogenic diabetes insipidus (HP:0009806)1.71790792
111Fair hair (HP:0002286)1.71714658
112Insomnia (HP:0100785)1.71633281
113Tetraplegia (HP:0002445)1.71411279
114Postural tremor (HP:0002174)1.71266114
115Dysmetric saccades (HP:0000641)1.70466267
116Cerebral hypomyelination (HP:0006808)1.69563624
117Neuronal loss in central nervous system (HP:0002529)1.69235634
118Spastic tetraparesis (HP:0001285)1.68897946
119Medial flaring of the eyebrow (HP:0010747)1.68055899
120Hepatoblastoma (HP:0002884)1.67569002
121Esotropia (HP:0000565)1.67566596
122Autism (HP:0000717)1.67206943
123Intestinal atresia (HP:0011100)1.67168494
124Thickened helices (HP:0000391)1.65929302
125Psychosis (HP:0000709)1.62811033
126Exotropia (HP:0000577)1.62359878

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.43831247
2EPHA44.09184604
3MARK13.88885295
4MAP3K93.45346272
5NTRK23.03153121
6KSR12.96380126
7MINK12.85628153
8MAP3K42.82102952
9NTRK12.72121783
10MAP2K72.41770280
11CASK2.25789749
12DAPK22.22665694
13PAK62.09442881
14SIK32.01762546
15TNIK1.92586274
16KSR21.86131415
17MAP2K41.63552205
18MAP3K121.63149701
19PRKD31.56000906
20CAMKK11.55106263
21RIPK41.54164024
22MAPK131.53999910
23PLK21.49660489
24CDK51.49234620
25DAPK11.48072730
26PNCK1.32567373
27SIK21.28596711
28CDK191.27160974
29PHKG11.23296775
30PHKG21.23296775
31PRKCG1.20677013
32PRPF4B1.15819565
33UHMK11.14192617
34BCR1.13360005
35TYRO31.09449743
36GRK51.06180360
37STK381.02561071
38DYRK21.01232249
39PKN10.99488454
40CAMK2A0.98401721
41CDK180.98053551
42MAP3K20.95636022
43SGK4940.95336419
44SGK2230.95336419
45CSNK1G30.94545044
46FES0.93876411
47SGK20.88648779
48CSNK1A1L0.88226670
49LATS20.88144251
50EPHA30.87260947
51CAMKK20.86711507
52CDK150.86430140
53EPHB20.84626641
54CDK140.82900432
55LMTK20.82109952
56MAP3K130.81919606
57CSNK1G10.81827652
58PAK30.80273234
59ARAF0.79482301
60CAMK10.76121143
61CSNK1G20.74733327
62STK110.74592427
63CAMK2B0.73970498
64CDK11A0.73950264
65FRK0.72461743
66SGK10.71421478
67DYRK1A0.70776715
68RAF10.67873018
69RET0.66700982
70SGK30.66284695
71CAMK1G0.60763493
72PTK2B0.59235241
73BMPR20.59063072
74TAOK10.58191029
75OXSR10.57686582
76PRKCZ0.57328734
77PRKCH0.56513427
78PRKCE0.56432195
79CCNB10.55592905
80MARK20.53739730
81TRIM280.51195763
82ROCK10.49574286
83FGR0.49198218
84CSNK1D0.49166344
85LIMK10.48840030
86CDC42BPA0.48837337
87NEK60.48803028
88RPS6KA30.46357064
89DDR20.45802637
90FYN0.45474966
91ALK0.44247198
92STK390.43692549
93ERBB20.42802956
94CSNK1A10.42178553
95FGFR20.41557225
96WNK30.41487416
97PRKG10.39846689
98ROCK20.39652551
99PDK10.39270809
100MAPK100.39030307
101MAP4K20.38818647
102BRSK10.38664562
103STK38L0.38024648
104RIPK10.37364226
105PDPK10.37173595
106PDGFRA0.36859825
107CAMK40.36481968
108RPS6KB10.36068912
109DMPK0.35443105
110PRKACA0.35129574
111MAP2K10.34901474
112ERBB30.34783058
113PIK3CA0.34374436
114CSNK1E0.34365697
115CAMK2D0.34344185
116BMPR1B0.32774130
117CAMK2G0.32318216
118FER0.31681377
119CDK30.31348315
120MAP3K70.30481662
121MAP3K10.30143653
122PRKCB0.30011750
123PINK10.29432574
124ICK0.28816443

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.97161688
2Synaptic vesicle cycle_Homo sapiens_hsa047213.09256529
3Circadian entrainment_Homo sapiens_hsa047132.71469863
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.67729109
5GABAergic synapse_Homo sapiens_hsa047272.66027205
6Long-term potentiation_Homo sapiens_hsa047202.64343024
7Glutamatergic synapse_Homo sapiens_hsa047242.63225520
8Olfactory transduction_Homo sapiens_hsa047402.56253340
9Morphine addiction_Homo sapiens_hsa050322.45098595
10Amphetamine addiction_Homo sapiens_hsa050312.38861656
11Salivary secretion_Homo sapiens_hsa049702.19253208
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.11759200
13Dopaminergic synapse_Homo sapiens_hsa047282.09900172
14Insulin secretion_Homo sapiens_hsa049111.96250185
15Cholinergic synapse_Homo sapiens_hsa047251.85755933
16Gastric acid secretion_Homo sapiens_hsa049711.84498676
17Taste transduction_Homo sapiens_hsa047421.73979115
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.72236152
19Long-term depression_Homo sapiens_hsa047301.70419388
20Serotonergic synapse_Homo sapiens_hsa047261.62929715
21Cocaine addiction_Homo sapiens_hsa050301.61867997
22Renin secretion_Homo sapiens_hsa049241.59925059
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59783534
24Oxytocin signaling pathway_Homo sapiens_hsa049211.58601827
25Calcium signaling pathway_Homo sapiens_hsa040201.57497656
26Axon guidance_Homo sapiens_hsa043601.47858075
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.47068261
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38353866
29GnRH signaling pathway_Homo sapiens_hsa049121.37300190
30Gap junction_Homo sapiens_hsa045401.36977299
31Vitamin B6 metabolism_Homo sapiens_hsa007501.34536137
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.32287272
33Glioma_Homo sapiens_hsa052141.29502258
34Collecting duct acid secretion_Homo sapiens_hsa049661.28746234
35Melanogenesis_Homo sapiens_hsa049161.28447985
36cAMP signaling pathway_Homo sapiens_hsa040241.26383438
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23710685
38Estrogen signaling pathway_Homo sapiens_hsa049151.21560217
39ErbB signaling pathway_Homo sapiens_hsa040121.21526356
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20796208
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19702811
42Type II diabetes mellitus_Homo sapiens_hsa049301.18551167
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14787969
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06426744
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06092927
46Dorso-ventral axis formation_Homo sapiens_hsa043201.05420620
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99464016
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90713498
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.89454250
50Oocyte meiosis_Homo sapiens_hsa041140.88443755
51Phototransduction_Homo sapiens_hsa047440.87743485
52Nitrogen metabolism_Homo sapiens_hsa009100.85603439
53Cardiac muscle contraction_Homo sapiens_hsa042600.82251299
54Vibrio cholerae infection_Homo sapiens_hsa051100.80483680
55Pancreatic secretion_Homo sapiens_hsa049720.79228107
56Butanoate metabolism_Homo sapiens_hsa006500.79032429
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.79006853
58Choline metabolism in cancer_Homo sapiens_hsa052310.78985915
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.77081969
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75228384
61Thyroid hormone synthesis_Homo sapiens_hsa049180.73355629
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73238555
63Dilated cardiomyopathy_Homo sapiens_hsa054140.72656415
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71004080
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70858517
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69083148
67MAPK signaling pathway_Homo sapiens_hsa040100.68867216
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68699437
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63087812
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62301147
71Ras signaling pathway_Homo sapiens_hsa040140.62225784
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61348225
73* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59559722
74Wnt signaling pathway_Homo sapiens_hsa043100.59436735
75VEGF signaling pathway_Homo sapiens_hsa043700.58879044
76Alcoholism_Homo sapiens_hsa050340.58156872
77Endometrial cancer_Homo sapiens_hsa052130.58096127
78beta-Alanine metabolism_Homo sapiens_hsa004100.57550896
79Rap1 signaling pathway_Homo sapiens_hsa040150.56300455
80Renal cell carcinoma_Homo sapiens_hsa052110.56048510
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.54972314
82Circadian rhythm_Homo sapiens_hsa047100.54140411
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53772891
84Glucagon signaling pathway_Homo sapiens_hsa049220.52907062
85mTOR signaling pathway_Homo sapiens_hsa041500.49925059
86Non-small cell lung cancer_Homo sapiens_hsa052230.48064405
87Inositol phosphate metabolism_Homo sapiens_hsa005620.47033039
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44470938
89Insulin signaling pathway_Homo sapiens_hsa049100.44382763
90Prion diseases_Homo sapiens_hsa050200.43301773
91Bile secretion_Homo sapiens_hsa049760.43079974
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42614076
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42236054
94Tight junction_Homo sapiens_hsa045300.42031428
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41895823
96Colorectal cancer_Homo sapiens_hsa052100.41282849
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40910908
98AMPK signaling pathway_Homo sapiens_hsa041520.39510301
99Fatty acid biosynthesis_Homo sapiens_hsa000610.39452640
100Fatty acid metabolism_Homo sapiens_hsa012120.37739009
101Hedgehog signaling pathway_Homo sapiens_hsa043400.37217051
102Endocytosis_Homo sapiens_hsa041440.37150000
103Type I diabetes mellitus_Homo sapiens_hsa049400.36746102
104African trypanosomiasis_Homo sapiens_hsa051430.35130250
105Steroid biosynthesis_Homo sapiens_hsa001000.34504048
106ABC transporters_Homo sapiens_hsa020100.32833793
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32208449
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31315756
109Chemokine signaling pathway_Homo sapiens_hsa040620.31062505
110Histidine metabolism_Homo sapiens_hsa003400.29894542
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29575920
112Hippo signaling pathway_Homo sapiens_hsa043900.28969657
113Prolactin signaling pathway_Homo sapiens_hsa049170.26815400
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.26597619
115Ovarian steroidogenesis_Homo sapiens_hsa049130.26160672

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