NRDE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.56547351
2response to pheromone (GO:0019236)4.38800549
3nuclear pore organization (GO:0006999)4.27757078
4DNA unwinding involved in DNA replication (GO:0006268)4.24142677
5ribosomal small subunit assembly (GO:0000028)4.21458917
6L-fucose catabolic process (GO:0042355)4.20448803
7fucose catabolic process (GO:0019317)4.20448803
8L-fucose metabolic process (GO:0042354)4.20448803
9nuclear pore complex assembly (GO:0051292)4.08365025
10maturation of SSU-rRNA (GO:0030490)4.06952911
11mitotic nuclear envelope disassembly (GO:0007077)3.95577163
12DNA strand elongation involved in DNA replication (GO:0006271)3.95382506
13folic acid-containing compound biosynthetic process (GO:0009396)3.88519887
14DNA replication initiation (GO:0006270)3.85425461
15neural tube formation (GO:0001841)3.79818093
16DNA strand elongation (GO:0022616)3.78329946
17protein complex biogenesis (GO:0070271)3.74987724
18regulation of gene silencing by RNA (GO:0060966)3.74121308
19regulation of posttranscriptional gene silencing (GO:0060147)3.74121308
20regulation of gene silencing by miRNA (GO:0060964)3.74121308
21mitochondrial respiratory chain complex I assembly (GO:0032981)3.69817433
22NADH dehydrogenase complex assembly (GO:0010257)3.69817433
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.69817433
24protein localization to kinetochore (GO:0034501)3.61923689
25telomere maintenance via semi-conservative replication (GO:0032201)3.61758314
26viral transcription (GO:0019083)3.60884356
27membrane disassembly (GO:0030397)3.60743300
28nuclear envelope disassembly (GO:0051081)3.60743300
29ribosomal small subunit biogenesis (GO:0042274)3.59405232
30DNA replication-dependent nucleosome assembly (GO:0006335)3.57363750
31DNA replication-dependent nucleosome organization (GO:0034723)3.57363750
32DNA deamination (GO:0045006)3.53628279
33IMP biosynthetic process (GO:0006188)3.49148925
34mitochondrial respiratory chain complex assembly (GO:0033108)3.46931528
35translational termination (GO:0006415)3.46767080
36indolalkylamine metabolic process (GO:0006586)3.44406980
37translesion synthesis (GO:0019985)3.42173994
38respiratory chain complex IV assembly (GO:0008535)3.35976597
39water-soluble vitamin biosynthetic process (GO:0042364)3.33718040
40detection of light stimulus involved in sensory perception (GO:0050962)3.30710012
41detection of light stimulus involved in visual perception (GO:0050908)3.30710012
42ribosome biogenesis (GO:0042254)3.28070583
43telomere maintenance via recombination (GO:0000722)3.26066857
44tryptophan catabolic process (GO:0006569)3.22577968
45indole-containing compound catabolic process (GO:0042436)3.22577968
46indolalkylamine catabolic process (GO:0046218)3.22577968
47DNA geometric change (GO:0032392)3.22474223
48formation of translation preinitiation complex (GO:0001731)3.21908612
49epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.21871250
50negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.21225779
51negative regulation of translation, ncRNA-mediated (GO:0040033)3.21225779
52regulation of translation, ncRNA-mediated (GO:0045974)3.21225779
53cytochrome complex assembly (GO:0017004)3.20103669
54DNA duplex unwinding (GO:0032508)3.18978916
55detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.18037104
56ribonucleoprotein complex biogenesis (GO:0022613)3.17425780
57regulation of histone H3-K9 methylation (GO:0051570)3.16718062
58translational elongation (GO:0006414)3.14981992
59mitotic recombination (GO:0006312)3.13412321
60pore complex assembly (GO:0046931)3.12964680
61cornea development in camera-type eye (GO:0061303)3.11217527
62kynurenine metabolic process (GO:0070189)3.08612775
63telomere maintenance via telomere lengthening (GO:0010833)3.08085493
64mitotic G1 DNA damage checkpoint (GO:0031571)3.06060449
65nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.05538047
66protein localization to chromosome, centromeric region (GO:0071459)3.04632629
67spliceosomal tri-snRNP complex assembly (GO:0000244)3.03482409
68nucleobase biosynthetic process (GO:0046112)3.02930557
69translational initiation (GO:0006413)3.02583870
70histone H2A monoubiquitination (GO:0035518)3.02064219
71DNA replication checkpoint (GO:0000076)2.97706871
72IMP metabolic process (GO:0046040)2.95055659
73mRNA cleavage (GO:0006379)2.94710734
74preassembly of GPI anchor in ER membrane (GO:0016254)2.91890301
75double-strand break repair via homologous recombination (GO:0000724)2.91472068
76recombinational repair (GO:0000725)2.91042057
77cellular ketone body metabolic process (GO:0046950)2.90032294
78meiotic chromosome segregation (GO:0045132)2.88955698
79mitotic chromosome condensation (GO:0007076)2.88591755
80oxidative demethylation (GO:0070989)2.87409881
81ribosomal large subunit biogenesis (GO:0042273)2.86734378
82nucleotide-excision repair, DNA gap filling (GO:0006297)2.85186461
83negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.84144159
84mismatch repair (GO:0006298)2.82863392
85regulation of nuclear cell cycle DNA replication (GO:0033262)2.81573727
86regulation of gene silencing (GO:0060968)2.81477728
87attachment of spindle microtubules to kinetochore (GO:0008608)2.81112391
88heterochromatin organization (GO:0070828)2.80240572
89spinal cord motor neuron differentiation (GO:0021522)2.80112895
90tryptophan metabolic process (GO:0006568)2.79141755
91nonmotile primary cilium assembly (GO:0035058)2.78755143
92postreplication repair (GO:0006301)2.78208296
93ncRNA 3-end processing (GO:0043628)2.78121447
94ribosome assembly (GO:0042255)2.77833343
95telomere organization (GO:0032200)2.77206903
96telomere maintenance (GO:0000723)2.76431579
97regulation of helicase activity (GO:0051095)2.75148254
98maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.74586651
99nuclear envelope organization (GO:0006998)2.74183357
100chromatin assembly (GO:0031497)2.73750315
101pre-miRNA processing (GO:0031054)2.73277544
102SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.72415628
103negative regulation of histone methylation (GO:0031061)2.71427669
104regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.71422398
105protein-cofactor linkage (GO:0018065)2.71141995
106regulation of hippo signaling (GO:0035330)2.70971395
107negative regulation of DNA-dependent DNA replication (GO:2000104)2.70697427
108male meiosis I (GO:0007141)2.70612680
109axoneme assembly (GO:0035082)2.70590108
110rRNA processing (GO:0006364)2.70516859
111rRNA catabolic process (GO:0016075)2.70406735
112cellular protein complex disassembly (GO:0043624)2.70193249
113regulation of spindle organization (GO:0090224)2.70063638
114replication fork processing (GO:0031297)2.69770001
115epithelial cilium movement (GO:0003351)2.69031729
116DNA conformation change (GO:0071103)2.69016495
117positive regulation of fatty acid transport (GO:2000193)2.68356627
118regulation of translational fidelity (GO:0006450)2.67654801
119rRNA metabolic process (GO:0016072)2.66863828
120positive regulation of chromosome segregation (GO:0051984)2.66676135
121RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.65529296
122mRNA splicing, via spliceosome (GO:0000398)2.65529296
123G1 DNA damage checkpoint (GO:0044783)2.64403360
124RNA splicing, via transesterification reactions (GO:0000375)2.63635766
125protein targeting to ER (GO:0045047)2.63321858
126cotranslational protein targeting to membrane (GO:0006613)2.62870035
127cell proliferation in forebrain (GO:0021846)2.62838006
128mitotic G1/S transition checkpoint (GO:0044819)2.62356204
129mitotic metaphase plate congression (GO:0007080)2.61827658
130protein K11-linked deubiquitination (GO:0035871)2.61764299
131positive regulation of defense response to virus by host (GO:0002230)2.61504112
132ketone body metabolic process (GO:1902224)2.60837900
133viral life cycle (GO:0019058)2.60804798
134negative regulation of RNA splicing (GO:0033119)2.60589875
135somite development (GO:0061053)2.59325544
136mannosylation (GO:0097502)2.57731644
137sulfation (GO:0051923)2.57555456
138base-excision repair (GO:0006284)2.57345965
139protein complex disassembly (GO:0043241)2.56498260
140mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.56222310
141regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.55428866
142regulation of mitotic spindle checkpoint (GO:1903504)2.55428866
143neuronal action potential (GO:0019228)2.55402505
144exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.55280350
145somatic hypermutation of immunoglobulin genes (GO:0016446)2.55188522
146somatic diversification of immune receptors via somatic mutation (GO:0002566)2.55188522
147kidney morphogenesis (GO:0060993)2.54889540
148mitotic sister chromatid segregation (GO:0000070)2.54455330
149nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.54353406
150protein polyglutamylation (GO:0018095)2.53413537
151cilium organization (GO:0044782)2.52188366
152nuclear-transcribed mRNA catabolic process (GO:0000956)2.52010026
153proteasome assembly (GO:0043248)2.51705267
154reciprocal DNA recombination (GO:0035825)2.51685864
155reciprocal meiotic recombination (GO:0007131)2.51685864
156regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.51454485
157regulation of DNA damage checkpoint (GO:2000001)2.51411789
158DNA demethylation (GO:0080111)2.51323992
159establishment of protein localization to endoplasmic reticulum (GO:0072599)2.51008172
160cilium or flagellum-dependent cell motility (GO:0001539)2.50819158
161positive regulation of gamma-delta T cell activation (GO:0046645)2.50410703
162chromatin assembly or disassembly (GO:0006333)2.49592686
163pseudouridine synthesis (GO:0001522)2.48360968
164indole-containing compound metabolic process (GO:0042430)2.48281864
165negative regulation of gene silencing (GO:0060969)2.48068988
166histone H3-K4 trimethylation (GO:0080182)2.44450449
167nephron epithelium morphogenesis (GO:0072088)2.44111299
168nephron tubule morphogenesis (GO:0072078)2.44111299
169cilium morphogenesis (GO:0060271)2.42252922
170mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.42114616
171rhodopsin mediated signaling pathway (GO:0016056)2.42008619
172piRNA metabolic process (GO:0034587)2.41948234
173cilium assembly (GO:0042384)2.41890183
174histone H3-K9 methylation (GO:0051567)2.41328803
175dopamine transport (GO:0015872)2.39830886
176regulation of rhodopsin mediated signaling pathway (GO:0022400)2.39570393
177rRNA modification (GO:0000154)2.38641594
178regulation of memory T cell differentiation (GO:0043380)2.38483499
179cardiovascular system development (GO:0072358)2.37715378
180synaptic transmission, cholinergic (GO:0007271)2.37586830
181RNA destabilization (GO:0050779)2.37434554
182DNA methylation involved in gamete generation (GO:0043046)2.36826550
183photoreceptor cell maintenance (GO:0045494)2.36504844
184positive regulation of icosanoid secretion (GO:0032305)2.35032466
185signal peptide processing (GO:0006465)2.34939021
186regulation of action potential (GO:0098900)2.34858398
187transmission of nerve impulse (GO:0019226)2.34170954
188multicellular organism reproduction (GO:0032504)2.33275085
189ATP synthesis coupled proton transport (GO:0015986)2.32841366
190energy coupled proton transport, down electrochemical gradient (GO:0015985)2.32841366
191GPI anchor metabolic process (GO:0006505)2.32442724
192embryonic epithelial tube formation (GO:0001838)2.32160713
193regulation of telomere maintenance (GO:0032204)2.30945043
194centriole replication (GO:0007099)2.30288392
195cilium movement (GO:0003341)2.29401802

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.39149095
2ZNF274_21170338_ChIP-Seq_K562_Hela4.12561753
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.58850383
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.44668765
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.32481459
6VDR_22108803_ChIP-Seq_LS180_Human3.28734565
7EZH2_22144423_ChIP-Seq_EOC_Human3.22730273
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.01532969
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.74721707
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.56061323
11GBX2_23144817_ChIP-Seq_PC3_Human2.49338606
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.47102517
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.42370052
14IGF1R_20145208_ChIP-Seq_DFB_Human2.42297747
15MYC_22102868_ChIP-Seq_BL_Human2.40100420
16EWS_26573619_Chip-Seq_HEK293_Human2.35465085
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.34819169
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33032554
19FUS_26573619_Chip-Seq_HEK293_Human2.28860041
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26372857
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.23262645
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.18834552
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.17659269
24CTBP1_25329375_ChIP-Seq_LNCAP_Human2.14086007
25TAF15_26573619_Chip-Seq_HEK293_Human2.10675425
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09810888
27POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08614608
28CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06721660
29SALL1_21062744_ChIP-ChIP_HESCs_Human2.04800105
30ER_23166858_ChIP-Seq_MCF-7_Human2.01913591
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.96889150
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.96339545
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.94280235
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.92506211
35XRN2_22483619_ChIP-Seq_HELA_Human1.91417124
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88894988
37VDR_23849224_ChIP-Seq_CD4+_Human1.81215635
38P300_19829295_ChIP-Seq_ESCs_Human1.80762658
39CIITA_25753668_ChIP-Seq_RAJI_Human1.79812296
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.79438485
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75636102
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.74584677
43FOXP3_21729870_ChIP-Seq_TREG_Human1.73757241
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73643838
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.73301920
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.72033898
47SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.70018428
48VDR_21846776_ChIP-Seq_THP-1_Human1.68321102
49MYC_18940864_ChIP-ChIP_HL60_Human1.67274141
50IRF8_22096565_ChIP-ChIP_GC-B_Human1.65971178
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.64141755
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.62034054
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61895170
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61817509
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61271780
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.60042210
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59805323
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.58901219
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58619840
60TP53_22573176_ChIP-Seq_HFKS_Human1.58308667
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57405833
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56304113
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55637762
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55126750
65KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.53602357
66IRF1_19129219_ChIP-ChIP_H3396_Human1.52087849
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51377670
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51377670
69AR_21909140_ChIP-Seq_LNCAP_Human1.50554527
70STAT3_23295773_ChIP-Seq_U87_Human1.49730835
71ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49174814
72E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48630778
73DCP1A_22483619_ChIP-Seq_HELA_Human1.46594906
74BCAT_22108803_ChIP-Seq_LS180_Human1.46463155
75MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45938871
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45467057
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44173131
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43407183
79NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.42769997
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42167764
81CBP_20019798_ChIP-Seq_JUKART_Human1.42097699
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42097699
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42067378
84TCF4_23295773_ChIP-Seq_U87_Human1.41248300
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.41144590
86HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41123033
87KDM5A_27292631_Chip-Seq_BREAST_Human1.39948031
88NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.39174355
89TFEB_21752829_ChIP-Seq_HELA_Human1.36956493
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35491965
91REST_21632747_ChIP-Seq_MESCs_Mouse1.35454415
92KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.35098926
93KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.35098926
94KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.35098926
95GABP_19822575_ChIP-Seq_HepG2_Human1.34433706
96SMAD4_21799915_ChIP-Seq_A2780_Human1.33789960
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33146621
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32117944
99FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32072226
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31951873
101AR_25329375_ChIP-Seq_VCAP_Human1.31598346
102YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31002351
103AR_21572438_ChIP-Seq_LNCaP_Human1.30099946
104MAF_26560356_Chip-Seq_TH1_Human1.29693518
105CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.29134838
106PIAS1_25552417_ChIP-Seq_VCAP_Human1.27453471
107MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.27018173
108SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26631696
109ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24970339
110THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24004068
111HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23698704
112ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23665098
113TP63_19390658_ChIP-ChIP_HaCaT_Human1.23481478
114YY1_21170310_ChIP-Seq_MESCs_Mouse1.23328254
115IRF8_21731497_ChIP-ChIP_J774_Mouse1.23220796
116GATA3_21878914_ChIP-Seq_MCF-7_Human1.22116406
117GATA1_22025678_ChIP-Seq_K562_Human1.22006492
118CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21698471
119SPI1_23547873_ChIP-Seq_NB4_Human1.21665855
120NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20641681
121FLI1_21867929_ChIP-Seq_TH2_Mouse1.20407239
122FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19739079
123RNF2_27304074_Chip-Seq_NSC_Mouse1.19219325
124KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17991704
125* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17783738
126TTF2_22483619_ChIP-Seq_HELA_Human1.16630661
127GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16496615
128FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16273442
129FOXA1_25329375_ChIP-Seq_VCAP_Human1.16273442
130MYB_26560356_Chip-Seq_TH1_Human1.15598919
131ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15294593
132ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15253956
133UTX_26944678_Chip-Seq_JUKART_Human1.15013963
134NANOG_19829295_ChIP-Seq_ESCs_Human1.14825766
135SOX2_19829295_ChIP-Seq_ESCs_Human1.14825766
136PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14386379
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13848464
138SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13426872
139ELK1_19687146_ChIP-ChIP_HELA_Human1.12496853
140NCOR_22424771_ChIP-Seq_293T_Human1.12238322
141AR_20517297_ChIP-Seq_VCAP_Human1.10954614
142TCF7_22412390_ChIP-Seq_EML_Mouse1.10174281
143PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09018848
144STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08926314
145SCL_19346495_ChIP-Seq_HPC-7_Human1.08611404
146MYB_26560356_Chip-Seq_TH2_Human1.08349096
147SMAD3_21741376_ChIP-Seq_EPCs_Human1.08094638
148MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07780900
149TCF4_22108803_ChIP-Seq_LS180_Human1.07444492
150SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07393725
151RUNX2_22187159_ChIP-Seq_PCA_Human1.07304690
152PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07062693
153E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06527098
154EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05661077
155EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05464816
156PRDM14_20953172_ChIP-Seq_ESCs_Human1.05292685
157TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04941342
158RUNX1_22412390_ChIP-Seq_EML_Mouse1.04480403
159NFE2_27457419_Chip-Seq_LIVER_Mouse1.04369088
160DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03835058
161HOXB7_26014856_ChIP-Seq_BT474_Human1.03709850
162STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03683054
163NOTCH1_21737748_ChIP-Seq_TLL_Human1.03427623
164RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02250142
165GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02118679
166CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01426707
167BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00988234
168HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99811900
169BP1_19119308_ChIP-ChIP_Hs578T_Human0.98980681
170KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98844882
171TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98390629
172FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98363191
173POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98268994
174EZH2_27294783_Chip-Seq_NPCs_Mouse0.98187550
175KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97484861
176TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97475764
177NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.97077421
178TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96826887
179ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96741271
180GATA3_26560356_Chip-Seq_TH2_Human0.94476321
181STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.93674542
182MAF_26560356_Chip-Seq_TH2_Human0.92239724
183ERA_21632823_ChIP-Seq_H3396_Human0.91550435
184TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91369767
185CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90733048
186SMAD4_21741376_ChIP-Seq_EPCs_Human0.90596756
187DROSHA_22980978_ChIP-Seq_HELA_Human0.89727188
188MYC_19829295_ChIP-Seq_ESCs_Human0.89144849

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.83249370
2MP0008057_abnormal_DNA_replication3.68935713
3MP0003111_abnormal_nucleus_morphology3.62760175
4MP0004957_abnormal_blastocyst_morpholog3.16448287
5MP0003077_abnormal_cell_cycle3.06176894
6MP0003693_abnormal_embryo_hatching3.05367941
7MP0002396_abnormal_hematopoietic_system2.98079708
8MP0008058_abnormal_DNA_repair2.68654563
9MP0003136_yellow_coat_color2.65182020
10MP0003646_muscle_fatigue2.45657495
11MP0010352_gastrointestinal_tract_polyps2.41845157
12MP0001835_abnormal_antigen_presentation2.35593544
13MP0004142_abnormal_muscle_tone2.35534405
14MP0003195_calcinosis2.33917110
15MP0008007_abnormal_cellular_replicative2.25879720
16MP0008877_abnormal_DNA_methylation2.24668150
17MP0002638_abnormal_pupillary_reflex2.16128715
18MP0005646_abnormal_pituitary_gland2.15732474
19MP0005551_abnormal_eye_electrophysiolog2.13229602
20MP0003763_abnormal_thymus_physiology2.11168522
21MP0001730_embryonic_growth_arrest1.90357890
22MP0001968_abnormal_touch/_nociception1.89722713
23MP0006072_abnormal_retinal_apoptosis1.86384517
24MP0005645_abnormal_hypothalamus_physiol1.84997389
25MP0001800_abnormal_humoral_immune1.83062387
26MP0004808_abnormal_hematopoietic_stem1.82366386
27MP0009046_muscle_twitch1.82087960
28MP0003787_abnormal_imprinting1.81423859
29MP0002398_abnormal_bone_marrow1.80896543
30MP0000350_abnormal_cell_proliferation1.78690891
31MP0005076_abnormal_cell_differentiation1.77019357
32MP0000631_abnormal_neuroendocrine_gland1.76817961
33MP0000685_abnormal_immune_system1.76626943
34MP0000372_irregular_coat_pigmentation1.75753945
35MP0009278_abnormal_bone_marrow1.74634686
36MP0002837_dystrophic_cardiac_calcinosis1.74589662
37MP0000383_abnormal_hair_follicle1.73412619
38MP0003786_premature_aging1.73174671
39MP0000703_abnormal_thymus_morphology1.72685017
40MP0010307_abnormal_tumor_latency1.71501355
41MP0002102_abnormal_ear_morphology1.69565791
42MP0001545_abnormal_hematopoietic_system1.66505915
43MP0005397_hematopoietic_system_phenotyp1.66505915
44MP0002938_white_spotting1.66081156
45MP0001986_abnormal_taste_sensitivity1.63636122
46MP0002722_abnormal_immune_system1.63091970
47MP0008872_abnormal_physiological_respon1.62930608
48MP0000490_abnormal_crypts_of1.62678191
49MP0004043_abnormal_pH_regulation1.60068834
50MP0008995_early_reproductive_senescence1.59132808
51MP0005671_abnormal_response_to1.58503643
52MP0000689_abnormal_spleen_morphology1.58317757
53MP0009745_abnormal_behavioral_response1.56298312
54MP0001485_abnormal_pinna_reflex1.56076148
55MP0000427_abnormal_hair_cycle1.55331135
56MP0002452_abnormal_antigen_presenting1.52848384
57MP0002876_abnormal_thyroid_physiology1.52248401
58MP0001672_abnormal_embryogenesis/_devel1.51216207
59MP0005380_embryogenesis_phenotype1.51216207
60MP0005253_abnormal_eye_physiology1.50665896
61MP0002723_abnormal_immune_serum1.50603527
62MP0000716_abnormal_immune_system1.48332166
63MP0002420_abnormal_adaptive_immunity1.47953852
64MP0002019_abnormal_tumor_incidence1.47492842
65MP0001819_abnormal_immune_cell1.46698524
66MP0002736_abnormal_nociception_after1.43648786
67MP0001697_abnormal_embryo_size1.41752373
68MP0003890_abnormal_embryonic-extraembry1.41139085
69MP0002429_abnormal_blood_cell1.40297549
70MP0008932_abnormal_embryonic_tissue1.39568627
71MP0004145_abnormal_muscle_electrophysio1.37136085
72MP0009333_abnormal_splenocyte_physiolog1.36723102
73MP0003984_embryonic_growth_retardation1.36059121
74MP0005389_reproductive_system_phenotype1.36047541
75MP0004147_increased_porphyrin_level1.35552769
76MP0002160_abnormal_reproductive_system1.34996585
77MP0002086_abnormal_extraembryonic_tissu1.34676212
78MP0005000_abnormal_immune_tolerance1.32825357
79MP0002138_abnormal_hepatobiliary_system1.32584215
80MP0005387_immune_system_phenotype1.32410997
81MP0001790_abnormal_immune_system1.32410997
82MP0002088_abnormal_embryonic_growth/wei1.32067258
83MP0000313_abnormal_cell_death1.31912173
84MP0006276_abnormal_autonomic_nervous1.31295977
85MP0003436_decreased_susceptibility_to1.30654153
86MP0002095_abnormal_skin_pigmentation1.30545805
87MP0002277_abnormal_respiratory_mucosa1.29966428
88MP0002080_prenatal_lethality1.29542121
89MP0001873_stomach_inflammation1.25882852
90MP0002163_abnormal_gland_morphology1.25284682
91MP0001919_abnormal_reproductive_system1.24649910
92MP0009785_altered_susceptibility_to1.23637514
93MP0004510_myositis1.23180382
94MP0002272_abnormal_nervous_system1.22736772
95MP0002084_abnormal_developmental_patter1.21033788
96MP0004197_abnormal_fetal_growth/weight/1.20413597
97MP0001293_anophthalmia1.19382798
98MP0002085_abnormal_embryonic_tissue1.19324429
99MP0002928_abnormal_bile_duct1.18622703
100MP0008875_abnormal_xenobiotic_pharmacok1.18396496
101MP0002132_abnormal_respiratory_system1.17140224
102MP0002877_abnormal_melanocyte_morpholog1.17074690
103MP0002254_reproductive_system_inflammat1.16907994
104MP0004885_abnormal_endolymph1.16547787
105MP0005084_abnormal_gallbladder_morpholo1.15826770
106MP0001486_abnormal_startle_reflex1.15295091
107MP0002148_abnormal_hypersensitivity_rea1.12618163
108MP0005025_abnormal_response_to1.12233107
109MP0004742_abnormal_vestibular_system1.12199351
110MP0001501_abnormal_sleep_pattern1.10921949
111MP0005379_endocrine/exocrine_gland_phen1.09884916
112MP0003566_abnormal_cell_adhesion1.07498047
113MP0002405_respiratory_system_inflammati1.07377185
114MP0002166_altered_tumor_susceptibility1.07374264
115MP0002064_seizures1.07152526
116MP0002733_abnormal_thermal_nociception1.06981524
117MP0001348_abnormal_lacrimal_gland1.06823983
118MP0000858_altered_metastatic_potential1.06528503
119MP0002557_abnormal_social/conspecific_i1.06065007
120MP0003880_abnormal_central_pattern1.05999941
121MP0008961_abnormal_basal_metabolism1.05927837
122MP0003878_abnormal_ear_physiology1.03028975
123MP0005377_hearing/vestibular/ear_phenot1.03028975
124MP0005075_abnormal_melanosome_morpholog1.02101466
125MP0003121_genomic_imprinting1.01572492
126MP0003011_delayed_dark_adaptation1.01241976
127MP0002735_abnormal_chemical_nociception1.00848818
128MP0002210_abnormal_sex_determination1.00484143
129MP0001970_abnormal_pain_threshold1.00233110
130MP0002572_abnormal_emotion/affect_behav0.99684968
131MP0005195_abnormal_posterior_eye0.99557256
132MP0005386_behavior/neurological_phenoty0.98983220
133MP0004924_abnormal_behavior0.98983220
134MP0002067_abnormal_sensory_capabilities0.97491486
135MP0010155_abnormal_intestine_physiology0.95491789
136MP0002006_tumorigenesis0.95290677
137MP0002419_abnormal_innate_immunity0.95225420
138MP0001145_abnormal_male_reproductive0.94845545
139MP0006292_abnormal_olfactory_placode0.94554422
140MP0004947_skin_inflammation0.94391789
141MP0003698_abnormal_male_reproductive0.92186120
142MP0009379_abnormal_foot_pigmentation0.91032957
143MP0000569_abnormal_digit_pigmentation0.90309081
144MP0004130_abnormal_muscle_cell0.90263901
145MP0000371_diluted_coat_color0.90042389
146MP0002653_abnormal_ependyma_morphology0.87572358
147MP0004133_heterotaxia0.87150073
148MP0003283_abnormal_digestive_organ0.86376196
149MP0001324_abnormal_eye_pigmentation0.85714078
150MP0003252_abnormal_bile_duct0.85642203
151MP0002092_abnormal_eye_morphology0.84556715
152MP0003091_abnormal_cell_migration0.83328165
153MP0010386_abnormal_urinary_bladder0.82671269
154MP0005621_abnormal_cell_physiology0.82543369
155MP0001849_ear_inflammation0.82280767
156MP0003718_maternal_effect0.81873505
157MP0001984_abnormal_olfaction0.81859326
158MP0003705_abnormal_hypodermis_morpholog0.81735424
159MP0000015_abnormal_ear_pigmentation0.80569756
160MP0002752_abnormal_somatic_nervous0.79692310
161MP0003938_abnormal_ear_development0.78791370
162MP0005464_abnormal_platelet_physiology0.78739472
163MP0001915_intracranial_hemorrhage0.78547690
164MP0005174_abnormal_tail_pigmentation0.78501769
165MP0000358_abnormal_cell_content/0.78438303
166MP0001944_abnormal_pancreas_morphology0.78413830
167MP0001502_abnormal_circadian_rhythm0.77810367
168MP0001845_abnormal_inflammatory_respons0.77480764
169MP0001929_abnormal_gametogenesis0.77266548
170MP0003172_abnormal_lysosome_physiology0.77032212
171MP0002063_abnormal_learning/memory/cond0.76954019
172MP0005410_abnormal_fertilization0.76771677
173MP0000470_abnormal_stomach_morphology0.76622979
174MP0000778_abnormal_nervous_system0.76059013
175MP0003448_altered_tumor_morphology0.75680952
176MP0005384_cellular_phenotype0.74348661
177MP0005391_vision/eye_phenotype0.73986938
178MP0005023_abnormal_wound_healing0.72799088
179MP0001529_abnormal_vocalization0.72303749
180MP0000026_abnormal_inner_ear0.71868684
181MP0003635_abnormal_synaptic_transmissio0.71807738
182MP0002075_abnormal_coat/hair_pigmentati0.70896355
183MP0005187_abnormal_penis_morphology0.70873584

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.12937353
2Pancreatic cysts (HP:0001737)4.01148792
3Abnormality of midbrain morphology (HP:0002418)3.85996585
4Molar tooth sign on MRI (HP:0002419)3.85996585
5Pancreatic fibrosis (HP:0100732)3.65887302
6Nephronophthisis (HP:0000090)3.64103063
7Abnormality of cells of the erythroid lineage (HP:0012130)3.57763689
8True hermaphroditism (HP:0010459)3.43457402
9Congenital stationary night blindness (HP:0007642)3.39394268
10Abnormal number of erythroid precursors (HP:0012131)3.38212266
11Chromsome breakage (HP:0040012)3.34045256
12Ependymoma (HP:0002888)3.17224430
13Hyperventilation (HP:0002883)3.16921007
14Abnormality of the renal medulla (HP:0100957)3.16653405
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.09153163
16Abnormality of the renal cortex (HP:0011035)3.07678453
17Abnormality of the fingertips (HP:0001211)3.00498004
18Chronic hepatic failure (HP:0100626)2.98954825
19Hypochromic anemia (HP:0001931)2.87173093
20Poikiloderma (HP:0001029)2.87123924
21Abnormality of DNA repair (HP:0003254)2.86709494
22Agnosia (HP:0010524)2.84738038
23Abnormal delayed hypersensitivity skin test (HP:0002963)2.83599124
24Genetic anticipation (HP:0003743)2.83175982
25Recurrent viral infections (HP:0004429)2.75878691
26Thrombocytosis (HP:0001894)2.74464768
27Absent thumb (HP:0009777)2.74391704
28Abnormality of chromosome stability (HP:0003220)2.70595326
29Attenuation of retinal blood vessels (HP:0007843)2.68179590
30Granulocytopenia (HP:0001913)2.67371501
31Medial flaring of the eyebrow (HP:0010747)2.66313233
32Polydipsia (HP:0001959)2.63570223
33Abnormal drinking behavior (HP:0030082)2.63570223
34Gaze-evoked nystagmus (HP:0000640)2.62307833
35Selective tooth agenesis (HP:0001592)2.60454128
36Pallor (HP:0000980)2.58917297
37Basal cell carcinoma (HP:0002671)2.58743802
3811 pairs of ribs (HP:0000878)2.57435247
39Tubular atrophy (HP:0000092)2.55546331
40Abnormality of T cells (HP:0002843)2.54236829
41Myelodysplasia (HP:0002863)2.54091073
42Abnormality of alanine metabolism (HP:0010916)2.53552221
43Hyperalaninemia (HP:0003348)2.53552221
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.53552221
45Amaurosis fugax (HP:0100576)2.53462683
46Squamous cell carcinoma (HP:0002860)2.52425500
47Absent radius (HP:0003974)2.51462781
48Eosinophilia (HP:0001880)2.50225030
49Duplicated collecting system (HP:0000081)2.48430974
50Prominent nose (HP:0000448)2.47622145
51Cystic liver disease (HP:0006706)2.47408809
52Progressive cerebellar ataxia (HP:0002073)2.47116046
53Cutaneous melanoma (HP:0012056)2.46984531
54Aplasia/Hypoplasia of the uvula (HP:0010293)2.45739433
55Abdominal situs inversus (HP:0003363)2.45036520
56Abnormality of abdominal situs (HP:0011620)2.45036520
57Patellar aplasia (HP:0006443)2.43954603
58Meckel diverticulum (HP:0002245)2.43530852
59T lymphocytopenia (HP:0005403)2.42039738
60Panhypogammaglobulinemia (HP:0003139)2.41047373
61Entropion (HP:0000621)2.41003435
62Type II lissencephaly (HP:0007260)2.40877861
63Abnormality of T cell physiology (HP:0011840)2.40320032
64Multiple enchondromatosis (HP:0005701)2.38324963
65Abnormality of pyrimidine metabolism (HP:0004353)2.37663924
66Recurrent fungal infections (HP:0002841)2.36704829
67Leukopenia (HP:0001882)2.36303977
68Impulsivity (HP:0100710)2.35786979
69Abnormality of T cell number (HP:0011839)2.34785600
70Aplasia involving forearm bones (HP:0009822)2.34136948
71Absent forearm bone (HP:0003953)2.34136948
72Abnormality of the ileum (HP:0001549)2.33861299
73Acute necrotizing encephalopathy (HP:0006965)2.32086597
74Abnormal rod and cone electroretinograms (HP:0008323)2.31294110
75Oral leukoplakia (HP:0002745)2.30506320
76Mitochondrial inheritance (HP:0001427)2.30041912
77Birth length less than 3rd percentile (HP:0003561)2.29973773
78Volvulus (HP:0002580)2.29973227
79Aplasia/Hypoplasia of the patella (HP:0006498)2.28011795
80Stomach cancer (HP:0012126)2.26017257
81Breast hypoplasia (HP:0003187)2.25444983
82Abnormality of the preputium (HP:0100587)2.24585385
83Colon cancer (HP:0003003)2.24456799
84Protruding tongue (HP:0010808)2.24369456
85IgM deficiency (HP:0002850)2.22109069
86Increased CSF lactate (HP:0002490)2.19884443
87Congenital hepatic fibrosis (HP:0002612)2.19380315
88Lymphoma (HP:0002665)2.17933698
89Abnormality of the pons (HP:0007361)2.16578010
90Broad-based gait (HP:0002136)2.16195622
91Macrocytic anemia (HP:0001972)2.14668848
92Sclerocornea (HP:0000647)2.13930369
93Abolished electroretinogram (ERG) (HP:0000550)2.13460475
94Hypoplasia of the pons (HP:0012110)2.11419407
95Anencephaly (HP:0002323)2.10974011
96Pustule (HP:0200039)2.10511902
97Bone marrow hypocellularity (HP:0005528)2.10494272
98Oligodactyly (hands) (HP:0001180)2.09777602
99Large for gestational age (HP:0001520)2.08642314
100Cellular immunodeficiency (HP:0005374)2.06632466
101Cerebral hypomyelination (HP:0006808)2.06343321
102Missing ribs (HP:0000921)2.05700386
103Rib fusion (HP:0000902)2.05478504
104Progressive macrocephaly (HP:0004481)2.03298462
105Congenital, generalized hypertrichosis (HP:0004540)2.03274818
106Male pseudohermaphroditism (HP:0000037)2.03258806
107Abnormality of cells of the lymphoid lineage (HP:0012140)2.02582132
108Medulloblastoma (HP:0002885)2.01319694
109Aplasia/Hypoplasia of the sacrum (HP:0008517)2.01269208
110Gait imbalance (HP:0002141)2.01122128
111Ectopic kidney (HP:0000086)2.00945348
112Rough bone trabeculation (HP:0100670)2.00917227
113Hepatocellular necrosis (HP:0001404)1.99457802
114Abnormal mitochondria in muscle tissue (HP:0008316)1.99072065
115Renal cortical cysts (HP:0000803)1.98675189
116Aplasia/Hypoplasia of the tibia (HP:0005772)1.98534328
117Cleft eyelid (HP:0000625)1.96600928
118Abnormality of eosinophils (HP:0001879)1.95751855
119Clumsiness (HP:0002312)1.95408321
120Limb hypertonia (HP:0002509)1.95048004
121Proximal placement of thumb (HP:0009623)1.94749904
122Abnormality of the renal collecting system (HP:0004742)1.94699828
123Polyuria (HP:0000103)1.94645628
124Duodenal stenosis (HP:0100867)1.94438921
125Small intestinal stenosis (HP:0012848)1.94438921
126Pendular nystagmus (HP:0012043)1.93763736
127Long eyelashes (HP:0000527)1.92741810
128Cerebellar dysplasia (HP:0007033)1.92717256
129Acute encephalopathy (HP:0006846)1.92322698
130Bilateral microphthalmos (HP:0007633)1.91690576
131Bony spicule pigmentary retinopathy (HP:0007737)1.91508873
132Lissencephaly (HP:0001339)1.91396631
133Congenital primary aphakia (HP:0007707)1.91114585
134Lymphopenia (HP:0001888)1.91104012
135Combined immunodeficiency (HP:0005387)1.89254178
136Absent/shortened dynein arms (HP:0200106)1.88860594
137Dynein arm defect of respiratory motile cilia (HP:0012255)1.88860594
138Shawl scrotum (HP:0000049)1.88391857
139Abnormal number of incisors (HP:0011064)1.87753641
140Febrile seizures (HP:0002373)1.87416148
141Bicuspid aortic valve (HP:0001647)1.87060491
142Supernumerary bones of the axial skeleton (HP:0009144)1.86376337
143Furrowed tongue (HP:0000221)1.86002140
144Deviation of the thumb (HP:0009603)1.85031205
145Tracheoesophageal fistula (HP:0002575)1.84993405
146Personality changes (HP:0000751)1.84722246
147Thyroiditis (HP:0100646)1.84345298
1483-Methylglutaconic aciduria (HP:0003535)1.83608991
149Absent rod-and cone-mediated responses on ERG (HP:0007688)1.82807041
150Neoplasm of the pancreas (HP:0002894)1.82271389
151Inability to walk (HP:0002540)1.81445187
152Optic disc pallor (HP:0000543)1.80754109
153Nephrogenic diabetes insipidus (HP:0009806)1.80684541
154Hepatic necrosis (HP:0002605)1.79161091
155Abnormality of the lower motor neuron (HP:0002366)1.79094884
156Leukocytosis (HP:0001974)1.77515931
157Clubbing of toes (HP:0100760)1.77454648
158Ureteral duplication (HP:0000073)1.77121171
159Concave nail (HP:0001598)1.76995838
160Abnormality of reticulocytes (HP:0004312)1.76121836
161Poor coordination (HP:0002370)1.75469870
162Aplasia/hypoplasia of the humerus (HP:0006507)1.75443654
163Aplasia/Hypoplasia of the tongue (HP:0010295)1.74534831
164Eczematoid dermatitis (HP:0000976)1.74340536
165Absent hand (HP:0004050)1.74278267
166Cafe-au-lait spot (HP:0000957)1.74264472
167Abnormal platelet volume (HP:0011876)1.74245426
168Hypoplastic iliac wings (HP:0002866)1.73793859
169Methylmalonic acidemia (HP:0002912)1.73544670
170High pitched voice (HP:0001620)1.72943475
171Abnormal spermatogenesis (HP:0008669)1.72905842
172Genital tract atresia (HP:0001827)1.72445899
173Optic nerve hypoplasia (HP:0000609)1.72288467
174Abnormality of the nasal septum (HP:0000419)1.71871538
175Bile duct proliferation (HP:0001408)1.69658467
176Abnormal biliary tract physiology (HP:0012439)1.69658467
177Lipid accumulation in hepatocytes (HP:0006561)1.69377216
178Postaxial foot polydactyly (HP:0001830)1.68534032
179Vaginal atresia (HP:0000148)1.66764235
180Tubulointerstitial nephritis (HP:0001970)1.66669932
181Abnormality of the labia minora (HP:0012880)1.66347381
182Decreased central vision (HP:0007663)1.66146763
183Partial agenesis of the corpus callosum (HP:0001338)1.64151483
184Hypothermia (HP:0002045)1.63069561
185IgG deficiency (HP:0004315)1.61815348

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.91448023
2BRD43.94151078
3CDK123.57381140
4CDC73.28796558
5BMPR1B3.08688483
6BUB12.94602497
7TAOK32.87501128
8ADRBK22.85183380
9MAP3K102.80353502
10TLK12.64770665
11MAP4K22.47368658
12WEE12.42747050
13WNK32.35010795
14MAP4K12.19682289
15CASK2.19258095
16NUAK12.18534846
17EEF2K2.13303640
18SRPK12.05591702
19INSRR1.92890516
20JAK31.89088930
21GRK11.87742310
22MAPK131.87687657
23TNIK1.86994824
24NEK21.84913570
25PKN21.81463456
26MAP3K141.80902960
27STK101.77490296
28NME21.74726377
29FLT31.66797495
30RPS6KB21.65257704
31CDK71.63513246
32PNCK1.59510096
33TYK21.56286818
34STK41.56110705
35TTK1.53682526
36WNK41.53590638
37DAPK21.53000786
38EPHA21.49874511
39ATR1.45933485
40EIF2AK11.44343891
41PASK1.43781977
42GRK61.43134069
43PINK11.40771031
44CDK41.39167246
45PLK11.37478917
46FGFR41.37337370
47TXK1.37308335
48NEK11.34169462
49PIM11.33917385
50TSSK61.31929568
51CHUK1.26867011
52MAPK151.25558565
53IKBKB1.23909741
54TNK21.20245084
55ACVR1B1.17480417
56CDK91.16423469
57TAOK21.16226450
58ALK1.16076280
59MAP3K81.15051216
60CHEK11.14964841
61TESK21.14681529
62MAP2K31.13970998
63PAK31.13327705
64CLK11.13232205
65CSF1R1.12568957
66CAMK1G1.11785896
67OXSR11.10683258
68ADRBK11.09953208
69AURKB1.07574244
70MAP3K41.03452465
71CHEK21.03274510
72SGK21.02127400
73VRK11.02072098
74AKT30.99765110
75TRIB30.98949129
76DYRK20.98594837
77KIT0.96217972
78ICK0.95836442
79MKNK10.95409858
80SIK20.94815203
81FGFR20.94209309
82TGFBR10.93239306
83TYRO30.90307881
84CAMK1D0.90099235
85ATM0.88704781
86NME10.85974802
87TEC0.85698150
88NEK90.84896689
89BRSK20.82976787
90MAP3K110.82953251
91CDK20.79745320
92PRKCG0.78959161
93MAP2K60.78850490
94STK390.78433487
95PLK40.77176130
96PAK40.76287411
97MAP3K130.75184656
98STK30.72634047
99CAMK10.71648603
100CAMKK20.71474886
101TTN0.69435361
102SGK2230.68777477
103SGK4940.68777477
104MELK0.68262691
105LRRK20.67056928
106MAP3K30.66232105
107PRKCQ0.65301707
108FGFR30.64970097
109PHKG20.63692136
110PHKG10.63692136
111BTK0.63668280
112MTOR0.63381209
113PIK3CA0.63058624
114STK160.62643859
115CSK0.62597418
116NTRK20.62042587
117SGK10.61365882
118BRSK10.61205020
119RPS6KA50.60787431
120BLK0.60097417
121SYK0.59768390
122PRKCE0.59489761
123CDK30.59220931
124MARK30.58754030
125ZAK0.58365043
126JAK10.58299656
127OBSCN0.58154361
128ITK0.57902244
129AURKA0.57433439
130MKNK20.56976059
131DYRK30.56793779
132ZAP700.56205024
133SCYL20.55452067
134TBK10.55444802
135EPHB10.54823716
136STK110.54442413
137CAMK40.53423870
138MARK10.53212428
139PKN10.52613131
140NLK0.52545224
141STK38L0.52171739
142MAP2K70.52030769
143CSNK2A20.51910571
144RPS6KA60.50945983
145CSNK1A10.50505032
146LCK0.50368943
147PTK2B0.48742546
148PDGFRA0.48171888
149CSNK1G10.47479455
150EIF2AK30.46298992
151PRKAA10.45974439
152PRKCZ0.45570984
153PLK20.44535459
154MAP3K70.44428763
155CSNK1D0.44200663
156IKBKE0.43181024
157PIK3CG0.43040056
158MUSK0.42747525
159CDK10.42683517
160PRKACA0.41950513
161HCK0.40862477
162PRKCH0.40702383
163RPS6KA40.40283846
164BMX0.39718301
165PRKAA20.39528063
166EPHA40.38860562
167LYN0.37613645
168CAMK2A0.37122622
169EIF2AK20.36863054
170TGFBR20.36447805
171PRKACB0.36255401
172TRIM280.36016575
173CSNK1G20.34926584
174WNK10.32193304

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.28437604
2Mismatch repair_Homo sapiens_hsa034303.55472250
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.29676237
4Base excision repair_Homo sapiens_hsa034103.10698807
5Ribosome_Homo sapiens_hsa030102.98181362
6Spliceosome_Homo sapiens_hsa030402.97694419
7One carbon pool by folate_Homo sapiens_hsa006702.90510209
8Oxidative phosphorylation_Homo sapiens_hsa001902.63396458
9RNA polymerase_Homo sapiens_hsa030202.54506852
10RNA transport_Homo sapiens_hsa030132.53102818
11Homologous recombination_Homo sapiens_hsa034402.47674202
12Phototransduction_Homo sapiens_hsa047442.45586821
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.45291335
14Non-homologous end-joining_Homo sapiens_hsa034502.39354957
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.38406435
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.35810964
17Nucleotide excision repair_Homo sapiens_hsa034202.34829515
18Linoleic acid metabolism_Homo sapiens_hsa005912.34226098
19Nitrogen metabolism_Homo sapiens_hsa009102.30742980
20Cell cycle_Homo sapiens_hsa041102.28428386
21Parkinsons disease_Homo sapiens_hsa050122.02039713
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.02028690
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.96066822
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.79415787
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.78649054
26Nicotine addiction_Homo sapiens_hsa050331.77487719
27Fanconi anemia pathway_Homo sapiens_hsa034601.77016419
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74889688
29Pyrimidine metabolism_Homo sapiens_hsa002401.74318741
30Proteasome_Homo sapiens_hsa030501.71872916
31Butanoate metabolism_Homo sapiens_hsa006501.66486632
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66409994
33RNA degradation_Homo sapiens_hsa030181.65795067
34Primary immunodeficiency_Homo sapiens_hsa053401.65419544
35Tryptophan metabolism_Homo sapiens_hsa003801.63304459
36mRNA surveillance pathway_Homo sapiens_hsa030151.59478712
37Huntingtons disease_Homo sapiens_hsa050161.55979784
38Herpes simplex infection_Homo sapiens_hsa051681.55918662
39Ether lipid metabolism_Homo sapiens_hsa005651.55835753
40Systemic lupus erythematosus_Homo sapiens_hsa053221.49426188
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.49227314
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.49216595
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49013480
44p53 signaling pathway_Homo sapiens_hsa041151.37297482
45Alzheimers disease_Homo sapiens_hsa050101.36657767
46Epstein-Barr virus infection_Homo sapiens_hsa051691.36620987
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34729500
48Measles_Homo sapiens_hsa051621.34242015
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33479808
50NF-kappa B signaling pathway_Homo sapiens_hsa040641.30322688
51Antigen processing and presentation_Homo sapiens_hsa046121.26015040
52Taste transduction_Homo sapiens_hsa047421.25377724
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.20165982
54Basal transcription factors_Homo sapiens_hsa030221.19733619
55ABC transporters_Homo sapiens_hsa020101.17867127
56Viral carcinogenesis_Homo sapiens_hsa052031.17144662
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16830949
58Protein export_Homo sapiens_hsa030601.15909917
59Small cell lung cancer_Homo sapiens_hsa052221.11463931
60Notch signaling pathway_Homo sapiens_hsa043301.08932229
61Morphine addiction_Homo sapiens_hsa050321.08351684
62Steroid hormone biosynthesis_Homo sapiens_hsa001401.06855408
63Chemical carcinogenesis_Homo sapiens_hsa052041.05233529
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01487927
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00874247
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98604616
67Cardiac muscle contraction_Homo sapiens_hsa042600.98232367
68B cell receptor signaling pathway_Homo sapiens_hsa046620.96794328
69Olfactory transduction_Homo sapiens_hsa047400.96330514
70HTLV-I infection_Homo sapiens_hsa051660.96187036
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94893799
72Acute myeloid leukemia_Homo sapiens_hsa052210.94878738
73Chronic myeloid leukemia_Homo sapiens_hsa052200.92457866
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92231159
75Caffeine metabolism_Homo sapiens_hsa002320.91747588
76Dorso-ventral axis formation_Homo sapiens_hsa043200.90124936
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89926068
78Retinol metabolism_Homo sapiens_hsa008300.87306187
79Apoptosis_Homo sapiens_hsa042100.87193183
80Regulation of autophagy_Homo sapiens_hsa041400.84711355
81Glycerolipid metabolism_Homo sapiens_hsa005610.84253072
82Peroxisome_Homo sapiens_hsa041460.83747008
83Arachidonic acid metabolism_Homo sapiens_hsa005900.82436397
84Influenza A_Homo sapiens_hsa051640.81383642
85Serotonergic synapse_Homo sapiens_hsa047260.80527117
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.80194092
87Leishmaniasis_Homo sapiens_hsa051400.79830992
88T cell receptor signaling pathway_Homo sapiens_hsa046600.79127026
89Selenocompound metabolism_Homo sapiens_hsa004500.79106832
90Ovarian steroidogenesis_Homo sapiens_hsa049130.77969365
91Lysine degradation_Homo sapiens_hsa003100.77115753
92Legionellosis_Homo sapiens_hsa051340.76110612
93Propanoate metabolism_Homo sapiens_hsa006400.75435378
94Purine metabolism_Homo sapiens_hsa002300.75291296
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.74324935
96Insulin secretion_Homo sapiens_hsa049110.73706192
97Biosynthesis of amino acids_Homo sapiens_hsa012300.72481814
98Circadian entrainment_Homo sapiens_hsa047130.71885663
99Glutamatergic synapse_Homo sapiens_hsa047240.71648636
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71036446
101Asthma_Homo sapiens_hsa053100.68426526
102MicroRNAs in cancer_Homo sapiens_hsa052060.68026621
103Toxoplasmosis_Homo sapiens_hsa051450.66352976
104Calcium signaling pathway_Homo sapiens_hsa040200.65696858
105Hepatitis B_Homo sapiens_hsa051610.64914709
106Thyroid cancer_Homo sapiens_hsa052160.64177258
107Non-small cell lung cancer_Homo sapiens_hsa052230.63523061
108Drug metabolism - other enzymes_Homo sapiens_hsa009830.63241187
109Pentose phosphate pathway_Homo sapiens_hsa000300.62671733
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61889659
111Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61523986
112Sulfur relay system_Homo sapiens_hsa041220.60714833
113GABAergic synapse_Homo sapiens_hsa047270.60253831
114mTOR signaling pathway_Homo sapiens_hsa041500.58798991
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.58420586
116Viral myocarditis_Homo sapiens_hsa054160.56038928
117Circadian rhythm_Homo sapiens_hsa047100.55554784
118Histidine metabolism_Homo sapiens_hsa003400.54912650
119Allograft rejection_Homo sapiens_hsa053300.54905533
120Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54662098
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52980103
122Metabolic pathways_Homo sapiens_hsa011000.52916060
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51323335
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.50800590
125Hedgehog signaling pathway_Homo sapiens_hsa043400.50185521
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49556967
127Osteoclast differentiation_Homo sapiens_hsa043800.49542731
128Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49022476
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47604560
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47306772
131Cocaine addiction_Homo sapiens_hsa050300.47181120
132Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44438321
133Cholinergic synapse_Homo sapiens_hsa047250.43924650
134Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43751659
135HIF-1 signaling pathway_Homo sapiens_hsa040660.41616822
136Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41616747
137Vitamin digestion and absorption_Homo sapiens_hsa049770.40455582
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40232533
139Colorectal cancer_Homo sapiens_hsa052100.39974835
140Cysteine and methionine metabolism_Homo sapiens_hsa002700.38288948
141Graft-versus-host disease_Homo sapiens_hsa053320.36879052
142Pancreatic cancer_Homo sapiens_hsa052120.36638421
143Pathways in cancer_Homo sapiens_hsa052000.36583426
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.36050601
145Shigellosis_Homo sapiens_hsa051310.35490317
146Type I diabetes mellitus_Homo sapiens_hsa049400.34759946
147Carbon metabolism_Homo sapiens_hsa012000.34607459
148Type II diabetes mellitus_Homo sapiens_hsa049300.33078928
149Salivary secretion_Homo sapiens_hsa049700.32930642
150Oocyte meiosis_Homo sapiens_hsa041140.32823487
151TNF signaling pathway_Homo sapiens_hsa046680.32406261
152Prostate cancer_Homo sapiens_hsa052150.31604934
153beta-Alanine metabolism_Homo sapiens_hsa004100.31382099
154Hematopoietic cell lineage_Homo sapiens_hsa046400.31181673
155Cyanoamino acid metabolism_Homo sapiens_hsa004600.31010924
156Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29634206
157Leukocyte transendothelial migration_Homo sapiens_hsa046700.28722501
158Folate biosynthesis_Homo sapiens_hsa007900.28697066
159Alcoholism_Homo sapiens_hsa050340.28696261
160Chemokine signaling pathway_Homo sapiens_hsa040620.28220311
161Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27893422
162Fructose and mannose metabolism_Homo sapiens_hsa000510.27869298
163Vascular smooth muscle contraction_Homo sapiens_hsa042700.27482683
164Dopaminergic synapse_Homo sapiens_hsa047280.26121381
165Basal cell carcinoma_Homo sapiens_hsa052170.25222610
166Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24050718
167Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23559489
168Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23442823
169Glycosaminoglycan degradation_Homo sapiens_hsa005310.21983152

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