

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | pyrimidine nucleobase catabolic process (GO:0006208) | 8.41446231 |
| 2 | nucleobase catabolic process (GO:0046113) | 6.38601814 |
| 3 | response to pheromone (GO:0019236) | 5.87644362 |
| 4 | central nervous system projection neuron axonogenesis (GO:0021952) | 5.37994659 |
| 5 | presynaptic membrane assembly (GO:0097105) | 5.33101183 |
| 6 | cell migration in hindbrain (GO:0021535) | 4.91887480 |
| 7 | presynaptic membrane organization (GO:0097090) | 4.88746333 |
| 8 | axonal fasciculation (GO:0007413) | 4.84107045 |
| 9 | layer formation in cerebral cortex (GO:0021819) | 4.76989804 |
| 10 | neuron recognition (GO:0008038) | 4.50432567 |
| 11 | dendrite morphogenesis (GO:0048813) | 4.30714484 |
| 12 | negative regulation of axon guidance (GO:1902668) | 4.26732605 |
| 13 | central nervous system neuron axonogenesis (GO:0021955) | 4.18158273 |
| 14 | neuron cell-cell adhesion (GO:0007158) | 4.08078778 |
| 15 | negative regulation of axon extension involved in axon guidance (GO:0048843) | 4.03415916 |
| 16 | establishment of mitochondrion localization (GO:0051654) | 4.02572578 |
| 17 | establishment of nucleus localization (GO:0040023) | 3.96133210 |
| 18 | auditory behavior (GO:0031223) | 3.95793210 |
| 19 | dendritic spine morphogenesis (GO:0060997) | 3.93567397 |
| 20 | positive regulation of synapse maturation (GO:0090129) | 3.90290921 |
| 21 | vocalization behavior (GO:0071625) | 3.85013487 |
| 22 | negative regulation of microtubule polymerization (GO:0031115) | 3.74325273 |
| 23 | axon extension (GO:0048675) | 3.70642882 |
| 24 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.70448510 |
| 25 | negative regulation of catenin import into nucleus (GO:0035414) | 3.68008415 |
| 26 | synaptic vesicle maturation (GO:0016188) | 3.67316219 |
| 27 | cerebellar granule cell differentiation (GO:0021707) | 3.57635637 |
| 28 | protein localization to synapse (GO:0035418) | 3.56216404 |
| 29 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 3.51145566 |
| 30 | hippocampus development (GO:0021766) | 3.44316161 |
| 31 | cerebellum development (GO:0021549) | 3.41199113 |
| 32 | regulation of axon guidance (GO:1902667) | 3.40372688 |
| 33 | gamma-aminobutyric acid transport (GO:0015812) | 3.38927493 |
| 34 | cranial nerve morphogenesis (GO:0021602) | 3.36295098 |
| 35 | cerebral cortex radially oriented cell migration (GO:0021799) | 3.36230570 |
| 36 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.34126920 |
| 37 | regulation of synapse structural plasticity (GO:0051823) | 3.28525106 |
| 38 | mechanosensory behavior (GO:0007638) | 3.28305563 |
| 39 | regulation of synapse maturation (GO:0090128) | 3.27522697 |
| 40 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.27150729 |
| 41 | positive regulation of synapse assembly (GO:0051965) | 3.25956558 |
| 42 | regulation of synapse assembly (GO:0051963) | 3.25909950 |
| 43 | neuron migration (GO:0001764) | 3.21979399 |
| 44 | sequestering of actin monomers (GO:0042989) | 3.19972051 |
| 45 | somite development (GO:0061053) | 3.17674530 |
| 46 | limb bud formation (GO:0060174) | 3.17320775 |
| 47 | neuron projection extension (GO:1990138) | 3.15669463 |
| 48 | regulation of axon extension involved in axon guidance (GO:0048841) | 3.14868019 |
| 49 | regulation of synapse organization (GO:0050807) | 3.14658001 |
| 50 | negative regulation of axon extension (GO:0030517) | 3.13748141 |
| 51 | synaptic vesicle exocytosis (GO:0016079) | 3.12142300 |
| 52 | axon extension involved in axon guidance (GO:0048846) | 3.11860054 |
| 53 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 3.11860054 |
| 54 | response to auditory stimulus (GO:0010996) | 3.10800303 |
| 55 | neural tube formation (GO:0001841) | 3.10219932 |
| 56 | retinal ganglion cell axon guidance (GO:0031290) | 3.04862347 |
| 57 | locomotory exploration behavior (GO:0035641) | 3.03036928 |
| 58 | postsynaptic membrane organization (GO:0001941) | 3.02603054 |
| 59 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.01895851 |
| 60 | exploration behavior (GO:0035640) | 3.00784169 |
| 61 | neuronal action potential propagation (GO:0019227) | 3.00707618 |
| 62 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.99555063 |
| 63 | extracellular fibril organization (GO:0043206) | 2.98808862 |
| 64 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.98777186 |
| 65 | cellular response to prostaglandin stimulus (GO:0071379) | 2.98254193 |
| 66 | nonmotile primary cilium assembly (GO:0035058) | 2.97245704 |
| 67 | transmission of nerve impulse (GO:0019226) | 2.96232892 |
| 68 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 2.95198915 |
| 69 | mitochondrion transport along microtubule (GO:0047497) | 2.95198915 |
| 70 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 2.94083593 |
| 71 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 2.91924436 |
| 72 | dopaminergic neuron differentiation (GO:0071542) | 2.91919074 |
| 73 | cardiac ventricle formation (GO:0003211) | 2.91370047 |
| 74 | spinal cord development (GO:0021510) | 2.90760695 |
| 75 | synapse assembly (GO:0007416) | 2.90660640 |
| 76 | positive regulation of filopodium assembly (GO:0051491) | 2.89814050 |
| 77 | positive regulation of action potential (GO:0045760) | 2.88747837 |
| 78 | cell differentiation in hindbrain (GO:0021533) | 2.87787149 |
| 79 | sympathetic nervous system development (GO:0048485) | 2.87108311 |
| 80 | cardiac chamber formation (GO:0003207) | 2.87085554 |
| 81 | regulation of respiratory system process (GO:0044065) | 2.86605450 |
| 82 | positive regulation of gastrulation (GO:2000543) | 2.86103086 |
| 83 | axonogenesis (GO:0007409) | 2.85697340 |
| 84 | innervation (GO:0060384) | 2.85265566 |
| 85 | positive regulation of mitochondrial fission (GO:0090141) | 2.84376951 |
| 86 | synaptic transmission, glutamatergic (GO:0035249) | 2.83299613 |
| 87 | epithelial cell differentiation involved in kidney development (GO:0035850) | 2.83228683 |
| 88 | nucleus localization (GO:0051647) | 2.82566742 |
| 89 | cerebellar Purkinje cell differentiation (GO:0021702) | 2.81406815 |
| 90 | glial cell proliferation (GO:0014009) | 2.81082613 |
| 91 | respiratory tube development (GO:0030323) | 2.80096528 |
| 92 | neurofilament cytoskeleton organization (GO:0060052) | 2.79156498 |
| 93 | negative regulation of axonogenesis (GO:0050771) | 2.78233881 |
| 94 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157) | 2.78155313 |
| 95 | behavioral response to nicotine (GO:0035095) | 2.77573032 |
| 96 | protein localization to cilium (GO:0061512) | 2.77439267 |
| 97 | regulation of synaptic vesicle exocytosis (GO:2000300) | 2.77257948 |
| 98 | olfactory bulb development (GO:0021772) | 2.76818803 |
| 99 | homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156) | 2.76594609 |
| 100 | neurotransmitter-gated ion channel clustering (GO:0072578) | 2.75335846 |
| 101 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 2.74023630 |
| 102 | regulation of axon extension (GO:0030516) | 2.73996313 |
| 103 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 2.73901135 |
| 104 | dendrite development (GO:0016358) | 2.73707277 |
| 105 | mesenchymal cell differentiation involved in kidney development (GO:0072161) | 2.69657091 |
| 106 | mesenchymal cell differentiation involved in renal system development (GO:2001012) | 2.69657091 |
| 107 | regulation of development, heterochronic (GO:0040034) | 2.69026805 |
| 108 | facial nerve structural organization (GO:0021612) | 2.68418695 |
| 109 | intraciliary transport (GO:0042073) | 2.67981158 |
| 110 | forebrain neuron differentiation (GO:0021879) | 2.67732528 |
| 111 | neuron projection morphogenesis (GO:0048812) | 2.66747084 |
| 112 | short-term memory (GO:0007614) | 2.65081455 |
| 113 | glycosphingolipid biosynthetic process (GO:0006688) | 2.64464883 |
| 114 | glutamate secretion (GO:0014047) | 2.63457964 |
| 115 | cell differentiation involved in kidney development (GO:0061005) | 2.63189863 |
| 116 | ganglion development (GO:0061548) | 2.61855389 |
| 117 | synapse organization (GO:0050808) | 2.61736901 |
| 118 | cerebral cortex cell migration (GO:0021795) | 2.61589365 |
| 119 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339) | 2.61410228 |
| 120 | negative regulation of oligodendrocyte differentiation (GO:0048715) | 2.61245233 |
| 121 | negative chemotaxis (GO:0050919) | 2.60640527 |
| 122 | startle response (GO:0001964) | 2.60434523 |
| 123 | regulation of extent of cell growth (GO:0061387) | 2.60178256 |
| 124 | regulation of dendritic spine morphogenesis (GO:0061001) | 2.59213978 |
| 125 | regulation of alternative mRNA splicing, via spliceosome (GO:0000381) | 2.56883631 |
| 126 | glomerulus development (GO:0032835) | 2.56529580 |
| 127 | positive regulation of dendritic spine development (GO:0060999) | 2.55072653 |
| 128 | tachykinin receptor signaling pathway (GO:0007217) | 2.55026945 |
| 129 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.54631866 |
| 130 | head development (GO:0060322) | 2.54495637 |
| 131 | neuromuscular synaptic transmission (GO:0007274) | 2.54272051 |
| 132 | behavioral response to ethanol (GO:0048149) | 2.53973177 |
| 133 | regulation of neuron migration (GO:2001222) | 2.53922099 |
| 134 | glutamate receptor signaling pathway (GO:0007215) | 2.53551493 |
| 135 | neuron-neuron synaptic transmission (GO:0007270) | 2.53547952 |
| 136 | negative regulation of stem cell proliferation (GO:2000647) | 2.53044446 |
| 137 | peptidyl-arginine N-methylation (GO:0035246) | 2.52482452 |
| 138 | peptidyl-arginine methylation (GO:0018216) | 2.52482452 |
| 139 | DNA integration (GO:0015074) | 2.52276596 |
| 140 | kidney morphogenesis (GO:0060993) | 2.50963294 |
| 141 | substrate-independent telencephalic tangential interneuron migration (GO:0021843) | 2.49467559 |
| 142 | substrate-independent telencephalic tangential migration (GO:0021826) | 2.49467559 |
| 143 | adult walking behavior (GO:0007628) | 2.49405191 |
| 144 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 2.47710772 |
| 145 | regulation of collateral sprouting (GO:0048670) | 2.47246286 |
| 146 | hindbrain development (GO:0030902) | 2.46936611 |
| 147 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.46135094 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.67328735 |
| 2 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 3.60236940 |
| 3 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.22423103 |
| 4 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 3.03508568 |
| 5 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.98503437 |
| 6 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.90242985 |
| 7 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.87971928 |
| 8 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.85904179 |
| 9 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.79525446 |
| 10 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.79525446 |
| 11 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.79065051 |
| 12 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.77954985 |
| 13 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.75540210 |
| 14 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.60946453 |
| 15 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.40524330 |
| 16 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 2.40104089 |
| 17 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.38754355 |
| 18 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.33909772 |
| 19 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.33453136 |
| 20 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.33265835 |
| 21 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.30149996 |
| 22 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 2.29056876 |
| 23 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.21929327 |
| 24 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 2.14073407 |
| 25 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.01240210 |
| 26 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.00653217 |
| 27 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.98858378 |
| 28 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.94521037 |
| 29 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.88266909 |
| 30 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.87513556 |
| 31 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.87012586 |
| 32 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.86301597 |
| 33 | EWS_26573619_Chip-Seq_HEK293_Human | 1.85827839 |
| 34 | VDR_22108803_ChIP-Seq_LS180_Human | 1.83523400 |
| 35 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.83422820 |
| 36 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.75248321 |
| 37 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.74205520 |
| 38 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.71359422 |
| 39 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.61019929 |
| 40 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.60327883 |
| 41 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.60215482 |
| 42 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.60152164 |
| 43 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.59704170 |
| 44 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.53702141 |
| 45 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.53418909 |
| 46 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.51902071 |
| 47 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.51167665 |
| 48 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.50140930 |
| 49 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.50069650 |
| 50 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.47824389 |
| 51 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.45530083 |
| 52 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.45218998 |
| 53 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.41164651 |
| 54 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.37325641 |
| 55 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.36984188 |
| 56 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.33847331 |
| 57 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.33844492 |
| 58 | P300_19829295_ChIP-Seq_ESCs_Human | 1.32824233 |
| 59 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.32444755 |
| 60 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.31949030 |
| 61 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 1.31250329 |
| 62 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.28895643 |
| 63 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.28513994 |
| 64 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.27801476 |
| 65 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.25133009 |
| 66 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.25042892 |
| 67 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.22760227 |
| 68 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.22053439 |
| 69 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.22053439 |
| 70 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.21335004 |
| 71 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.20463285 |
| 72 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.20054007 |
| 73 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.18828747 |
| 74 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.18613573 |
| 75 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.18613573 |
| 76 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.18030380 |
| 77 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.17213718 |
| 78 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.16895356 |
| 79 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.16228080 |
| 80 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.15861834 |
| 81 | AR_19668381_ChIP-Seq_PC3_Human | 1.15358141 |
| 82 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.14668067 |
| 83 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.14397482 |
| 84 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.13494154 |
| 85 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.12804118 |
| 86 | SOX9_26525672_Chip-Seq_HEART_Mouse | 1.12660204 |
| 87 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.11461507 |
| 88 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 1.11153808 |
| 89 | * SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.10236161 |
| 90 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.09549283 |
| 91 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.09334560 |
| 92 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.08658625 |
| 93 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.08050885 |
| 94 | TCF4_23295773_ChIP-Seq_U87_Human | 1.08017617 |
| 95 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.06927315 |
| 96 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.06796161 |
| 97 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.06161496 |
| 98 | AR_25329375_ChIP-Seq_VCAP_Human | 1.05889752 |
| 99 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.04864968 |
| 100 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.04502701 |
| 101 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.03967120 |
| 102 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.03771092 |
| 103 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.03520147 |
| 104 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.03369429 |
| 105 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.03310377 |
| 106 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.02108412 |
| 107 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.01531125 |
| 108 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.01507364 |
| 109 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 1.01119027 |
| 110 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.00920736 |
| 111 | FUS_26573619_Chip-Seq_HEK293_Human | 1.00551353 |
| 112 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.00521051 |
| 113 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.99965146 |
| 114 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.99462910 |
| 115 | ELK4_26923725_Chip-Seq_MESODERM_Mouse | 0.99336512 |
| 116 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.98222076 |
| 117 | TBX3_20139965_ChIP-Seq_MESCs_Mouse | 0.97614767 |
| 118 | TBX3_20139965_ChIP-Seq_ESCs_Mouse | 0.97236051 |
| 119 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.97072004 |
| 120 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.96952450 |
| 121 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 0.96665669 |
| 122 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.96469441 |
| 123 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.96164365 |
| 124 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.95794254 |
| 125 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.92720990 |
| 126 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 0.92661308 |
| 127 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.92124182 |
| 128 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.91989868 |
| 129 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.91125740 |
| 130 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.90712512 |
| 131 | STAT3_23295773_ChIP-Seq_U87_Human | 0.89961112 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 3.54140575 |
| 2 | MP0000778_abnormal_nervous_system | 3.25621014 |
| 3 | MP0003122_maternal_imprinting | 2.74535291 |
| 4 | MP0000569_abnormal_digit_pigmentation | 2.72557695 |
| 5 | MP0000537_abnormal_urethra_morphology | 2.61894716 |
| 6 | MP0002822_catalepsy | 2.55831213 |
| 7 | MP0006276_abnormal_autonomic_nervous | 2.49446397 |
| 8 | MP0003880_abnormal_central_pattern | 2.44243720 |
| 9 | MP0005423_abnormal_somatic_nervous | 2.43526854 |
| 10 | MP0002184_abnormal_innervation | 2.35634000 |
| 11 | MP0003635_abnormal_synaptic_transmissio | 2.32947797 |
| 12 | MP0002653_abnormal_ependyma_morphology | 2.31980655 |
| 13 | MP0002063_abnormal_learning/memory/cond | 2.14967177 |
| 14 | MP0002638_abnormal_pupillary_reflex | 2.10172438 |
| 15 | MP0004270_analgesia | 2.04665008 |
| 16 | MP0002282_abnormal_trachea_morphology | 1.83022113 |
| 17 | MP0002938_white_spotting | 1.82690855 |
| 18 | MP0010030_abnormal_orbit_morphology | 1.82381069 |
| 19 | MP0003121_genomic_imprinting | 1.80715436 |
| 20 | MP0001188_hyperpigmentation | 1.78067629 |
| 21 | MP0003119_abnormal_digestive_system | 1.77586558 |
| 22 | MP0010386_abnormal_urinary_bladder | 1.75030356 |
| 23 | MP0002249_abnormal_larynx_morphology | 1.74026209 |
| 24 | MP0003385_abnormal_body_wall | 1.73856004 |
| 25 | MP0000566_synostosis | 1.72897892 |
| 26 | MP0003942_abnormal_urinary_system | 1.71358436 |
| 27 | MP0003890_abnormal_embryonic-extraembry | 1.67326286 |
| 28 | MP0002734_abnormal_mechanical_nocicepti | 1.67275297 |
| 29 | MP0008789_abnormal_olfactory_epithelium | 1.65664925 |
| 30 | MP0002102_abnormal_ear_morphology | 1.65183396 |
| 31 | MP0000049_abnormal_middle_ear | 1.64939890 |
| 32 | MP0005187_abnormal_penis_morphology | 1.61178498 |
| 33 | MP0002557_abnormal_social/conspecific_i | 1.59474389 |
| 34 | MP0000955_abnormal_spinal_cord | 1.59107371 |
| 35 | MP0001486_abnormal_startle_reflex | 1.55643219 |
| 36 | MP0003115_abnormal_respiratory_system | 1.53308823 |
| 37 | MP0003861_abnormal_nervous_system | 1.52559935 |
| 38 | MP0002572_abnormal_emotion/affect_behav | 1.50918325 |
| 39 | MP0004811_abnormal_neuron_physiology | 1.49101311 |
| 40 | MP0001984_abnormal_olfaction | 1.47753714 |
| 41 | MP0003787_abnormal_imprinting | 1.45563194 |
| 42 | MP0000534_abnormal_ureter_morphology | 1.45156726 |
| 43 | MP0000631_abnormal_neuroendocrine_gland | 1.44450974 |
| 44 | MP0005499_abnormal_olfactory_system | 1.43762362 |
| 45 | MP0005394_taste/olfaction_phenotype | 1.43762362 |
| 46 | MP0001529_abnormal_vocalization | 1.43137742 |
| 47 | MP0001968_abnormal_touch/_nociception | 1.41737730 |
| 48 | MP0003137_abnormal_impulse_conducting | 1.40780007 |
| 49 | MP0002152_abnormal_brain_morphology | 1.40454627 |
| 50 | MP0009250_abnormal_appendicular_skeleto | 1.40376585 |
| 51 | MP0002882_abnormal_neuron_morphology | 1.38550195 |
| 52 | MP0005248_abnormal_Harderian_gland | 1.38350678 |
| 53 | MP0008877_abnormal_DNA_methylation | 1.38097230 |
| 54 | MP0004133_heterotaxia | 1.36823604 |
| 55 | MP0002751_abnormal_autonomic_nervous | 1.34545202 |
| 56 | MP0009745_abnormal_behavioral_response | 1.32495950 |
| 57 | MP0002067_abnormal_sensory_capabilities | 1.31510525 |
| 58 | MP0004142_abnormal_muscle_tone | 1.25927597 |
| 59 | MP0002733_abnormal_thermal_nociception | 1.25226519 |
| 60 | MP0001440_abnormal_grooming_behavior | 1.24674259 |
| 61 | MP0003315_abnormal_perineum_morphology | 1.24612230 |
| 62 | MP0002064_seizures | 1.24564330 |
| 63 | MP0009046_muscle_twitch | 1.20355389 |
| 64 | MP0003755_abnormal_palate_morphology | 1.18633448 |
| 65 | MP0002735_abnormal_chemical_nociception | 1.17598194 |
| 66 | MP0002116_abnormal_craniofacial_bone | 1.16727668 |
| 67 | MP0003567_abnormal_fetal_cardiomyocyte | 1.16146104 |
| 68 | MP0004858_abnormal_nervous_system | 1.15213497 |
| 69 | MP0005645_abnormal_hypothalamus_physiol | 1.14994313 |
| 70 | MP0005367_renal/urinary_system_phenotyp | 1.14875990 |
| 71 | MP0000516_abnormal_urinary_system | 1.14875990 |
| 72 | MP0002752_abnormal_somatic_nervous | 1.12085626 |
| 73 | MP0005503_abnormal_tendon_morphology | 1.11860696 |
| 74 | MP0000026_abnormal_inner_ear | 1.11368215 |
| 75 | MP0005386_behavior/neurological_phenoty | 1.11108378 |
| 76 | MP0004924_abnormal_behavior | 1.11108378 |
| 77 | MP0001293_anophthalmia | 1.10132504 |
| 78 | MP0009780_abnormal_chondrocyte_physiolo | 1.08122220 |
| 79 | MP0002081_perinatal_lethality | 1.07709078 |
| 80 | MP0003283_abnormal_digestive_organ | 1.07352857 |
| 81 | MP0008569_lethality_at_weaning | 1.07322706 |
| 82 | MP0003938_abnormal_ear_development | 1.06363719 |
| 83 | MP0004885_abnormal_endolymph | 1.05660088 |
| 84 | MP0009053_abnormal_anal_canal | 1.05186344 |
| 85 | MP0002932_abnormal_joint_morphology | 1.04380703 |
| 86 | MP0001970_abnormal_pain_threshold | 1.02678798 |
| 87 | MP0006292_abnormal_olfactory_placode | 1.01770358 |
| 88 | MP0004742_abnormal_vestibular_system | 1.01756055 |
| 89 | MP0002234_abnormal_pharynx_morphology | 1.00091862 |
| 90 | MP0002272_abnormal_nervous_system | 0.99591793 |
| 91 | MP0001286_abnormal_eye_development | 0.97230760 |
| 92 | MP0001299_abnormal_eye_distance/ | 0.97172398 |
| 93 | MP0003935_abnormal_craniofacial_develop | 0.96135118 |
| 94 | MP0001177_atelectasis | 0.95228287 |
| 95 | MP0002233_abnormal_nose_morphology | 0.95020476 |
| 96 | MP0002909_abnormal_adrenal_gland | 0.94974997 |
| 97 | MP0006072_abnormal_retinal_apoptosis | 0.92804740 |
| 98 | MP0002066_abnormal_motor_capabilities/c | 0.91408030 |
| 99 | MP0008961_abnormal_basal_metabolism | 0.90359154 |
| 100 | MP0000751_myopathy | 0.90188204 |
| 101 | MP0004145_abnormal_muscle_electrophysio | 0.89852760 |
| 102 | MP0005253_abnormal_eye_physiology | 0.88574804 |
| 103 | MP0001905_abnormal_dopamine_level | 0.88322734 |
| 104 | MP0005551_abnormal_eye_electrophysiolog | 0.87800709 |
| 105 | MP0002736_abnormal_nociception_after | 0.87372588 |
| 106 | MP0004215_abnormal_myocardial_fiber | 0.86938343 |
| 107 | MP0002837_dystrophic_cardiac_calcinosis | 0.83964040 |
| 108 | MP0005508_abnormal_skeleton_morphology | 0.83418844 |
| 109 | MP0005391_vision/eye_phenotype | 0.81847133 |
| 110 | MP0002697_abnormal_eye_size | 0.81825719 |
| 111 | MP0003136_yellow_coat_color | 0.81558635 |
| 112 | MP0005195_abnormal_posterior_eye | 0.81549267 |
| 113 | MP0003937_abnormal_limbs/digits/tail_de | 0.81451169 |
| 114 | MP0002177_abnormal_outer_ear | 0.80292694 |
| 115 | MP0002069_abnormal_eating/drinking_beha | 0.80242268 |
| 116 | MP0000462_abnormal_digestive_system | 0.79649224 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Hepatoblastoma (HP:0002884) | 3.40679005 |
| 2 | Exotropia (HP:0000577) | 3.14264835 |
| 3 | Agitation (HP:0000713) | 3.01346835 |
| 4 | Broad-based gait (HP:0002136) | 2.96879568 |
| 5 | Renal duplication (HP:0000075) | 2.92986301 |
| 6 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.82325064 |
| 7 | Short 4th metacarpal (HP:0010044) | 2.82325064 |
| 8 | Retinal dysplasia (HP:0007973) | 2.74713872 |
| 9 | Medial flaring of the eyebrow (HP:0010747) | 2.73882444 |
| 10 | Excessive salivation (HP:0003781) | 2.72888393 |
| 11 | Drooling (HP:0002307) | 2.72888393 |
| 12 | Midline defect of the nose (HP:0004122) | 2.69299468 |
| 13 | Pachygyria (HP:0001302) | 2.68229242 |
| 14 | Congenital primary aphakia (HP:0007707) | 2.67973297 |
| 15 | Progressive cerebellar ataxia (HP:0002073) | 2.66497096 |
| 16 | Lissencephaly (HP:0001339) | 2.65230153 |
| 17 | True hermaphroditism (HP:0010459) | 2.65223320 |
| 18 | Limb dystonia (HP:0002451) | 2.64416872 |
| 19 | Vaginal atresia (HP:0000148) | 2.64253867 |
| 20 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 2.60335436 |
| 21 | Hypoplasia of the brainstem (HP:0002365) | 2.60335436 |
| 22 | Nephrogenic diabetes insipidus (HP:0009806) | 2.59674105 |
| 23 | Atonic seizures (HP:0010819) | 2.56671167 |
| 24 | Elfin facies (HP:0004428) | 2.45476117 |
| 25 | Myelomeningocele (HP:0002475) | 2.44712329 |
| 26 | Hyperventilation (HP:0002883) | 2.43051613 |
| 27 | Pancreatic fibrosis (HP:0100732) | 2.42230263 |
| 28 | Epileptic encephalopathy (HP:0200134) | 2.41926433 |
| 29 | Lymphangioma (HP:0100764) | 2.40640739 |
| 30 | Nephronophthisis (HP:0000090) | 2.37574063 |
| 31 | Pancreatic cysts (HP:0001737) | 2.36165377 |
| 32 | Tracheomalacia (HP:0002779) | 2.31324593 |
| 33 | Hyperacusis (HP:0010780) | 2.30969505 |
| 34 | Protruding tongue (HP:0010808) | 2.28912463 |
| 35 | Sacral dimple (HP:0000960) | 2.27774560 |
| 36 | Heterochromia iridis (HP:0001100) | 2.26580734 |
| 37 | Bell-shaped thorax (HP:0001591) | 2.26257619 |
| 38 | Renovascular hypertension (HP:0100817) | 2.23737475 |
| 39 | Myokymia (HP:0002411) | 2.23669514 |
| 40 | Abnormality of midbrain morphology (HP:0002418) | 2.21838412 |
| 41 | Molar tooth sign on MRI (HP:0002419) | 2.21838412 |
| 42 | Shoulder girdle muscle weakness (HP:0003547) | 2.21348835 |
| 43 | Morphological abnormality of the middle ear (HP:0008609) | 2.21318602 |
| 44 | Cutaneous finger syndactyly (HP:0010554) | 2.20429064 |
| 45 | Cortical dysplasia (HP:0002539) | 2.18447337 |
| 46 | Abnormality of the lower motor neuron (HP:0002366) | 2.18408330 |
| 47 | Rimmed vacuoles (HP:0003805) | 2.17032085 |
| 48 | Polyphagia (HP:0002591) | 2.15457861 |
| 49 | Amyotrophic lateral sclerosis (HP:0007354) | 2.14371831 |
| 50 | Ankle clonus (HP:0011448) | 2.12679601 |
| 51 | Vitreoretinal degeneration (HP:0000655) | 2.10221445 |
| 52 | Abnormality of the aortic arch (HP:0012303) | 2.09659268 |
| 53 | Gait imbalance (HP:0002141) | 2.09466108 |
| 54 | Postaxial hand polydactyly (HP:0001162) | 2.07538107 |
| 55 | Urinary urgency (HP:0000012) | 2.07456783 |
| 56 | Abnormality of the pubic bones (HP:0003172) | 2.07388788 |
| 57 | Abnormality of the 4th metacarpal (HP:0010012) | 2.06558242 |
| 58 | Narrow nasal bridge (HP:0000446) | 2.05587404 |
| 59 | Focal seizures (HP:0007359) | 2.05367809 |
| 60 | Overriding aorta (HP:0002623) | 2.03913744 |
| 61 | Flat cornea (HP:0007720) | 2.02420809 |
| 62 | Polymicrogyria (HP:0002126) | 2.01037345 |
| 63 | Wrist flexion contracture (HP:0001239) | 1.98531752 |
| 64 | Narrow forehead (HP:0000341) | 1.98201277 |
| 65 | High anterior hairline (HP:0009890) | 1.98036473 |
| 66 | Insomnia (HP:0100785) | 1.97978355 |
| 67 | Pointed chin (HP:0000307) | 1.97362604 |
| 68 | Intestinal atresia (HP:0011100) | 1.97160513 |
| 69 | Neoplasm of the heart (HP:0100544) | 1.96153927 |
| 70 | Amblyopia (HP:0000646) | 1.96148036 |
| 71 | Optic nerve hypoplasia (HP:0000609) | 1.95449151 |
| 72 | Abnormality of the intervertebral disk (HP:0005108) | 1.95063254 |
| 73 | Inability to walk (HP:0002540) | 1.94539584 |
| 74 | Chronic hepatic failure (HP:0100626) | 1.93411726 |
| 75 | Shallow orbits (HP:0000586) | 1.93366241 |
| 76 | Hypoventilation (HP:0002791) | 1.92954863 |
| 77 | Mutism (HP:0002300) | 1.92701465 |
| 78 | Back pain (HP:0003418) | 1.92404188 |
| 79 | Specific learning disability (HP:0001328) | 1.92093290 |
| 80 | Obsessive-compulsive behavior (HP:0000722) | 1.91692703 |
| 81 | Micropenis (HP:0000054) | 1.91624119 |
| 82 | Absent speech (HP:0001344) | 1.91604282 |
| 83 | Abnormality of the renal medulla (HP:0100957) | 1.91079418 |
| 84 | Hypsarrhythmia (HP:0002521) | 1.90797634 |
| 85 | Poor eye contact (HP:0000817) | 1.89274317 |
| 86 | Split foot (HP:0001839) | 1.87897946 |
| 87 | Poor coordination (HP:0002370) | 1.87654959 |
| 88 | Broad foot (HP:0001769) | 1.87513439 |
| 89 | Cutaneous syndactyly (HP:0012725) | 1.87467798 |
| 90 | Abnormal eating behavior (HP:0100738) | 1.86601500 |
| 91 | Ulnar claw (HP:0001178) | 1.86455949 |
| 92 | Occipital encephalocele (HP:0002085) | 1.85941631 |
| 93 | Abnormality of the hip-girdle musculature (HP:0001445) | 1.84371760 |
| 94 | Abnormality of the musculature of the pelvis (HP:0001469) | 1.84371760 |
| 95 | Dialeptic seizures (HP:0011146) | 1.84353704 |
| 96 | Spastic tetraplegia (HP:0002510) | 1.84332466 |
| 97 | Genetic anticipation (HP:0003743) | 1.84316961 |
| 98 | Megalocornea (HP:0000485) | 1.84309919 |
| 99 | Sleep apnea (HP:0010535) | 1.84057753 |
| 100 | Abnormality of the diencephalon (HP:0010662) | 1.83367701 |
| 101 | Impaired vibration sensation in the lower limbs (HP:0002166) | 1.83280384 |
| 102 | Patellar aplasia (HP:0006443) | 1.83276146 |
| 103 | Hip dysplasia (HP:0001385) | 1.82810314 |
| 104 | Short philtrum (HP:0000322) | 1.82621756 |
| 105 | Tented upper lip vermilion (HP:0010804) | 1.82533656 |
| 106 | Intellectual disability, moderate (HP:0002342) | 1.82473514 |
| 107 | Hypochromic microcytic anemia (HP:0004840) | 1.82343842 |
| 108 | Failure to thrive in infancy (HP:0001531) | 1.82267906 |
| 109 | Trigonocephaly (HP:0000243) | 1.82014081 |
| 110 | Action tremor (HP:0002345) | 1.81600115 |
| 111 | Abnormality of the labia minora (HP:0012880) | 1.80917898 |
| 112 | Epileptiform EEG discharges (HP:0011182) | 1.80836513 |
| 113 | Type II lissencephaly (HP:0007260) | 1.80762323 |
| 114 | Bifid tongue (HP:0010297) | 1.80551885 |
| 115 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.78959521 |
| 116 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.78959521 |
| 117 | Genital tract atresia (HP:0001827) | 1.78700422 |
| 118 | Focal motor seizures (HP:0011153) | 1.78032071 |
| 119 | Anencephaly (HP:0002323) | 1.78010111 |
| 120 | Abnormality of the corticospinal tract (HP:0002492) | 1.76038774 |
| 121 | Short foot (HP:0001773) | 1.75114702 |
| 122 | Decreased testicular size (HP:0008734) | 1.74597298 |
| 123 | Scrotal hypoplasia (HP:0000046) | 1.74593432 |
| 124 | Colon cancer (HP:0003003) | 1.74014059 |
| 125 | Omphalocele (HP:0001539) | 1.73063146 |
| 126 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.72780961 |
| 127 | Truncal ataxia (HP:0002078) | 1.72763245 |
| 128 | Febrile seizures (HP:0002373) | 1.72706863 |
| 129 | Decreased muscle mass (HP:0003199) | 1.72704895 |
| 130 | Spina bifida occulta (HP:0003298) | 1.72277292 |
| 131 | Labial hypoplasia (HP:0000066) | 1.71928406 |
| 132 | Hyperglycinemia (HP:0002154) | 1.70804006 |
| 133 | Renal hypoplasia (HP:0000089) | 1.70141312 |
| 134 | Lower limb muscle weakness (HP:0007340) | 1.69957339 |
| 135 | Progressive inability to walk (HP:0002505) | 1.69552432 |
| 136 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.69139736 |
| 137 | Optic nerve coloboma (HP:0000588) | 1.68506649 |
| 138 | Patellar dislocation (HP:0002999) | 1.68406899 |
| 139 | Cupped ear (HP:0000378) | 1.68083790 |
| 140 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.67641813 |
| 141 | Postaxial foot polydactyly (HP:0001830) | 1.67638087 |
| 142 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.66945412 |
| 143 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 1.66887297 |
| 144 | Neoplasm of the adrenal cortex (HP:0100641) | 1.66716359 |
| 145 | Hemiparesis (HP:0001269) | 1.65785825 |
| 146 | Anophthalmia (HP:0000528) | 1.64551640 |
| 147 | EEG with generalized epileptiform discharges (HP:0011198) | 1.63959759 |
| 148 | Abnormality of salivation (HP:0100755) | 1.63838491 |
| 149 | Embryonal renal neoplasm (HP:0011794) | 1.62150520 |
| 150 | Esotropia (HP:0000565) | 1.61550881 |
| 151 | Dysdiadochokinesis (HP:0002075) | 1.61315159 |
| 152 | Megalencephaly (HP:0001355) | 1.61132917 |
| 153 | Visual hallucinations (HP:0002367) | 1.61024732 |
| 154 | Asymmetry of the thorax (HP:0001555) | 1.60296411 |
| 155 | Anteriorly placed anus (HP:0001545) | 1.59587111 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MARK1 | 6.72894681 |
| 2 | SIK3 | 3.59260622 |
| 3 | ERBB3 | 3.18540337 |
| 4 | DYRK2 | 3.11595042 |
| 5 | NTRK2 | 3.09542105 |
| 6 | KSR1 | 2.69961621 |
| 7 | TRIM28 | 2.57017577 |
| 8 | BCR | 2.40552164 |
| 9 | FGFR2 | 2.34009355 |
| 10 | MAPK13 | 2.28858188 |
| 11 | MINK1 | 2.15804385 |
| 12 | MAP4K2 | 2.13969561 |
| 13 | EPHB2 | 2.13118034 |
| 14 | CASK | 2.08342468 |
| 15 | SIK2 | 1.85300322 |
| 16 | TYRO3 | 1.81507928 |
| 17 | MAP3K4 | 1.81432894 |
| 18 | LATS2 | 1.80985908 |
| 19 | UHMK1 | 1.76052052 |
| 20 | MAP2K7 | 1.65548569 |
| 21 | MAP3K9 | 1.54987288 |
| 22 | PINK1 | 1.40154474 |
| 23 | PHKG2 | 1.36760497 |
| 24 | PHKG1 | 1.36760497 |
| 25 | DDR2 | 1.31061224 |
| 26 | PDGFRA | 1.26504938 |
| 27 | LIMK1 | 1.23706703 |
| 28 | PAK6 | 1.22756886 |
| 29 | WNK3 | 1.22548875 |
| 30 | DAPK2 | 1.22255696 |
| 31 | NTRK3 | 1.22214975 |
| 32 | PRPF4B | 1.11643687 |
| 33 | RPS6KA4 | 1.08961548 |
| 34 | ICK | 1.08859062 |
| 35 | DYRK1A | 1.07652711 |
| 36 | CDK5 | 1.05202029 |
| 37 | FRK | 1.00460272 |
| 38 | CSNK1G2 | 1.00132364 |
| 39 | MKNK2 | 0.99462903 |
| 40 | CDK18 | 0.99072599 |
| 41 | PLK2 | 0.96066300 |
| 42 | INSRR | 0.90733709 |
| 43 | TAOK2 | 0.88693294 |
| 44 | MAP2K4 | 0.88119500 |
| 45 | CSNK1G3 | 0.87977961 |
| 46 | PAK3 | 0.87814249 |
| 47 | IRAK2 | 0.87307063 |
| 48 | BMPR1B | 0.86698924 |
| 49 | OBSCN | 0.86694986 |
| 50 | EPHA4 | 0.86438881 |
| 51 | EPHA3 | 0.86332581 |
| 52 | CSNK1A1L | 0.86063040 |
| 53 | SGK494 | 0.85712603 |
| 54 | SGK223 | 0.85712603 |
| 55 | BRD4 | 0.84958924 |
| 56 | ERBB2 | 0.84785771 |
| 57 | RET | 0.82482073 |
| 58 | CDK14 | 0.79885403 |
| 59 | CDK15 | 0.79519148 |
| 60 | CDK19 | 0.78057349 |
| 61 | TNIK | 0.77880268 |
| 62 | PRKCG | 0.75838725 |
| 63 | MARK2 | 0.75098908 |
| 64 | BCKDK | 0.71824333 |
| 65 | ROCK1 | 0.71330233 |
| 66 | FGFR1 | 0.71000377 |
| 67 | STK38L | 0.70636611 |
| 68 | MAP3K6 | 0.70224465 |
| 69 | CDK11A | 0.68234738 |
| 70 | NTRK1 | 0.64528852 |
| 71 | * PRKCE | 0.63702067 |
| 72 | CSNK1G1 | 0.61471787 |
| 73 | FGFR4 | 0.59212927 |
| 74 | RPS6KA2 | 0.58901189 |
| 75 | ADRBK2 | 0.57955483 |
| 76 | SGK2 | 0.56725323 |
| 77 | * PRKCZ | 0.56632251 |
| 78 | NUAK1 | 0.55941629 |
| 79 | AKT3 | 0.54493319 |
| 80 | PTK2B | 0.54065877 |
| 81 | CAMK1G | 0.53851605 |
| 82 | DYRK3 | 0.53740560 |
| 83 | FER | 0.53254855 |
| 84 | MAPK9 | 0.52967911 |
| 85 | ADRBK1 | 0.52234225 |
| 86 | MAP3K12 | 0.50962324 |
| 87 | CAMKK1 | 0.50934967 |
| 88 | FLT3 | 0.50892658 |
| 89 | YES1 | 0.50881025 |
| 90 | PNCK | 0.50687565 |
| 91 | VRK1 | 0.49699384 |
| 92 | PRKD3 | 0.49547479 |
| 93 | TIE1 | 0.49396166 |
| 94 | DYRK1B | 0.49154623 |
| 95 | CAMK4 | 0.49067559 |
| 96 | CDK3 | 0.47594312 |
| 97 | CCNB1 | 0.46598281 |
| 98 | PDGFRB | 0.46393687 |
| 99 | CSNK1D | 0.45533154 |
| 100 | MAPK15 | 0.45026727 |
| 101 | ILK | 0.44235844 |
| 102 | ROCK2 | 0.42875578 |
| 103 | CAMK2A | 0.42213925 |
| 104 | PKN1 | 0.42080968 |
| 105 | SRPK1 | 0.41974762 |
| 106 | GRK1 | 0.41759919 |
| 107 | OXSR1 | 0.41480024 |
| 108 | PLK3 | 0.40639517 |
| 109 | PRKACA | 0.40516306 |
| 110 | DMPK | 0.40494225 |
| 111 | MAP3K10 | 0.40369144 |
| 112 | FGR | 0.40182167 |
| 113 | CAMK1 | 0.39587278 |
| 114 | MKNK1 | 0.39484233 |
| 115 | PRKACB | 0.39167611 |
| 116 | ZAK | 0.38870912 |
| 117 | CSNK1E | 0.38081562 |
| 118 | CSNK1A1 | 0.36994497 |
| 119 | TGFBR1 | 0.36677889 |
| 120 | MAPK8 | 0.36159628 |
| 121 | PTK2 | 0.35921042 |
| 122 | FYN | 0.35612629 |
| 123 | DAPK1 | 0.34222890 |
| 124 | CAMKK2 | 0.33407389 |
| 125 | PLK4 | 0.33245038 |
| 126 | PRKCI | 0.33163188 |
| 127 | SGK3 | 0.32535734 |
| 128 | LATS1 | 0.32120811 |
| 129 | TSSK6 | 0.31845242 |
| 130 | AKT2 | 0.31567585 |
| 131 | RIPK1 | 0.31375476 |
| 132 | PRKAA1 | 0.31147711 |
| 133 | PKN2 | 0.30493598 |
| 134 | CAMK2B | 0.30253497 |
| 135 | PRKG1 | 0.29786093 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 3.13947637 |
| 2 | Axon guidance_Homo sapiens_hsa04360 | 2.89153046 |
| 3 | Basal cell carcinoma_Homo sapiens_hsa05217 | 2.22173683 |
| 4 | GABAergic synapse_Homo sapiens_hsa04727 | 2.16966029 |
| 5 | Circadian entrainment_Homo sapiens_hsa04713 | 2.12438376 |
| 6 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.09805630 |
| 7 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.09115891 |
| 8 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.05103701 |
| 9 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.04855463 |
| 10 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.02665057 |
| 11 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.89031436 |
| 12 | Morphine addiction_Homo sapiens_hsa05032 | 1.81839345 |
| 13 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.77381939 |
| 14 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.73845017 |
| 15 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.71547015 |
| 16 | Endometrial cancer_Homo sapiens_hsa05213 | 1.68870916 |
| 17 | Protein export_Homo sapiens_hsa03060 | 1.66406663 |
| 18 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 1.60590103 |
| 19 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.57811236 |
| 20 | Colorectal cancer_Homo sapiens_hsa05210 | 1.57609185 |
| 21 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.57021450 |
| 22 | Taste transduction_Homo sapiens_hsa04742 | 1.56696258 |
| 23 | Gap junction_Homo sapiens_hsa04540 | 1.55819186 |
| 24 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.52416491 |
| 25 | Wnt signaling pathway_Homo sapiens_hsa04310 | 1.46954071 |
| 26 | Cocaine addiction_Homo sapiens_hsa05030 | 1.46111364 |
| 27 | Parkinsons disease_Homo sapiens_hsa05012 | 1.46085117 |
| 28 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.43033130 |
| 29 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.42068214 |
| 30 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.40096021 |
| 31 | Long-term depression_Homo sapiens_hsa04730 | 1.38225351 |
| 32 | Long-term potentiation_Homo sapiens_hsa04720 | 1.38089395 |
| 33 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.37468077 |
| 34 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.37193767 |
| 35 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.36386678 |
| 36 | Melanogenesis_Homo sapiens_hsa04916 | 1.32984360 |
| 37 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.32959119 |
| 38 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.31163273 |
| 39 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.30873410 |
| 40 | Olfactory transduction_Homo sapiens_hsa04740 | 1.30552859 |
| 41 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.30151302 |
| 42 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.29219886 |
| 43 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.28310313 |
| 44 | Insulin secretion_Homo sapiens_hsa04911 | 1.24443048 |
| 45 | Renin secretion_Homo sapiens_hsa04924 | 1.21154096 |
| 46 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.20231445 |
| 47 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.19328311 |
| 48 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.13802861 |
| 49 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.12814401 |
| 50 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.10861309 |
| 51 | Renal cell carcinoma_Homo sapiens_hsa05211 | 1.09260429 |
| 52 | Basal transcription factors_Homo sapiens_hsa03022 | 1.09093338 |
| 53 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.07983465 |
| 54 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.03178445 |
| 55 | Glioma_Homo sapiens_hsa05214 | 1.02683207 |
| 56 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.02433663 |
| 57 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.02288840 |
| 58 | Phototransduction_Homo sapiens_hsa04744 | 1.02209104 |
| 59 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.01528194 |
| 60 | Huntingtons disease_Homo sapiens_hsa05016 | 1.00618137 |
| 61 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.00244511 |
| 62 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.99814272 |
| 63 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.98548006 |
| 64 | Adherens junction_Homo sapiens_hsa04520 | 0.95126243 |
| 65 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.93087773 |
| 66 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.91351880 |
| 67 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.90876195 |
| 68 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.89837814 |
| 69 | Alcoholism_Homo sapiens_hsa05034 | 0.88203397 |
| 70 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.88043243 |
| 71 | Salivary secretion_Homo sapiens_hsa04970 | 0.87103956 |
| 72 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.86813892 |
| 73 | Alzheimers disease_Homo sapiens_hsa05010 | 0.86766283 |
| 74 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.85930200 |
| 75 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.84994726 |
| 76 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.83567479 |
| 77 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.82474827 |
| 78 | Viral myocarditis_Homo sapiens_hsa05416 | 0.81839720 |
| 79 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.80818289 |
| 80 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.80770812 |
| 81 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.79546753 |
| 82 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.78491298 |
| 83 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.77523039 |
| 84 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.76900112 |
| 85 | Tight junction_Homo sapiens_hsa04530 | 0.76386642 |
| 86 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.76179257 |
| 87 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.75983019 |
| 88 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.75094800 |
| 89 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.74089542 |
| 90 | Circadian rhythm_Homo sapiens_hsa04710 | 0.71896053 |
| 91 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.71816919 |
| 92 | RNA degradation_Homo sapiens_hsa03018 | 0.69807511 |
| 93 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.69645739 |
| 94 | Pathways in cancer_Homo sapiens_hsa05200 | 0.67971429 |
| 95 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.67497460 |
| 96 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.67186310 |
| 97 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.67073923 |
| 98 | Focal adhesion_Homo sapiens_hsa04510 | 0.66801155 |
| 99 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.66466554 |
| 100 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.66419438 |
| 101 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.66294194 |
| 102 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.64078870 |
| 103 | RNA polymerase_Homo sapiens_hsa03020 | 0.62990989 |
| 104 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.62283842 |
| 105 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.61392501 |
| 106 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.61310043 |
| 107 | Lysine degradation_Homo sapiens_hsa00310 | 0.60250619 |
| 108 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.60188941 |
| 109 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.59414847 |
| 110 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.59125728 |
| 111 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.58804408 |
| 112 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.57565829 |
| 113 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.55998893 |
| 114 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.55298853 |
| 115 | Melanoma_Homo sapiens_hsa05218 | 0.54594802 |
| 116 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.53846856 |
| 117 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.53100936 |
| 118 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.52391413 |
| 119 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.52119253 |
| 120 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.51301127 |
| 121 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.50078292 |
| 122 | Endocytosis_Homo sapiens_hsa04144 | 0.49659373 |
| 123 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.49374523 |
| 124 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.49080350 |
| 125 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.48514212 |
| 126 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.45535856 |
| 127 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.44176756 |
| 128 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.40405088 |
| 129 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.40297107 |
| 130 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.39723101 |
| 131 | Peroxisome_Homo sapiens_hsa04146 | 0.37177036 |
| 132 | Spliceosome_Homo sapiens_hsa03040 | 0.35247004 |
| 133 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.33069412 |
| 134 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.32446167 |
| 135 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.31302300 |
| 136 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.30095765 |
| 137 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.27963221 |
| 138 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.27147814 |

