NRF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for 'nuclear factor (erythroid-derived 2)-like 1' which has an official symbol of NFE2L1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sister chromatid segregation (GO:0000819)4.64021252
2DNA topological change (GO:0006265)4.53760325
3mitotic sister chromatid cohesion (GO:0007064)4.48409050
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.44056451
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.38827620
6ribosomal small subunit biogenesis (GO:0042274)4.28576757
7DNA replication initiation (GO:0006270)4.05502932
8mitotic chromosome condensation (GO:0007076)4.00276619
9maturation of SSU-rRNA (GO:0030490)3.93901101
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.83953267
11negative regulation of cell killing (GO:0031342)3.83953267
12viral transcription (GO:0019083)3.76856303
13antigen processing and presentation of endogenous antigen (GO:0019883)3.74846149
14ribosomal large subunit biogenesis (GO:0042273)3.74653636
15DNA strand elongation involved in DNA replication (GO:0006271)3.71604010
16CENP-A containing nucleosome assembly (GO:0034080)3.65729606
17translational termination (GO:0006415)3.65200700
18telomere maintenance via semi-conservative replication (GO:0032201)3.61730736
19positive regulation of gamma-delta T cell activation (GO:0046645)3.59833705
20DNA strand elongation (GO:0022616)3.58983717
21termination of RNA polymerase III transcription (GO:0006386)3.56291855
22transcription elongation from RNA polymerase III promoter (GO:0006385)3.56291855
23proteasome assembly (GO:0043248)3.56046559
24chromatin remodeling at centromere (GO:0031055)3.50101537
25DNA unwinding involved in DNA replication (GO:0006268)3.46600413
26ribosomal small subunit assembly (GO:0000028)3.43264152
27DNA ligation (GO:0006266)3.38442842
28mitotic metaphase plate congression (GO:0007080)3.31278235
29ribonucleoprotein complex biogenesis (GO:0022613)3.27446578
30regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.25871454
31telomere maintenance via recombination (GO:0000722)3.23807884
32mRNA splice site selection (GO:0006376)3.20828953
33DNA replication checkpoint (GO:0000076)3.20273883
34DNA replication-independent nucleosome organization (GO:0034724)3.16380701
35DNA replication-independent nucleosome assembly (GO:0006336)3.16380701
36V(D)J recombination (GO:0033151)3.14636460
37mitotic recombination (GO:0006312)3.13540638
38NIK/NF-kappaB signaling (GO:0038061)3.13454026
39negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.11728243
40regulation of B cell receptor signaling pathway (GO:0050855)3.11102057
41rRNA processing (GO:0006364)3.09091711
42establishment of integrated proviral latency (GO:0075713)3.08034860
43translational initiation (GO:0006413)3.07351457
44microtubule depolymerization (GO:0007019)3.04496586
45regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.04097686
46nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.03719710
47metaphase plate congression (GO:0051310)3.02988601
48kinetochore organization (GO:0051383)3.02865160
49positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.02454978
50positive regulation of mitotic sister chromatid separation (GO:1901970)3.02454978
51positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.02454978
523-UTR-mediated mRNA stabilization (GO:0070935)3.00858711
53negative T cell selection (GO:0043383)3.00690097
54transcription elongation from RNA polymerase I promoter (GO:0006362)3.00304195
55rRNA metabolic process (GO:0016072)3.00279229
56translational elongation (GO:0006414)2.99124672
57nuclear pore complex assembly (GO:0051292)2.98807981
58telomere maintenance via telomere lengthening (GO:0010833)2.98207733
59spliceosomal tri-snRNP complex assembly (GO:0000244)2.97870805
60poly(A)+ mRNA export from nucleus (GO:0016973)2.97368172
61histone H3-K36 demethylation (GO:0070544)2.95928474
62N-terminal protein amino acid acetylation (GO:0006474)2.94811485
63cotranslational protein targeting to membrane (GO:0006613)2.94665075
64SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.93962661
65nucleotide-excision repair, DNA gap filling (GO:0006297)2.93650736
66viral mRNA export from host cell nucleus (GO:0046784)2.93343752
67positive T cell selection (GO:0043368)2.92293322
68antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.91599865
69protein targeting to ER (GO:0045047)2.91211850
70histone H2A acetylation (GO:0043968)2.90408326
71regulation of double-strand break repair via homologous recombination (GO:0010569)2.90067373
72termination of RNA polymerase I transcription (GO:0006363)2.89979869
73kinetochore assembly (GO:0051382)2.89434520
74histone exchange (GO:0043486)2.88963857
75protein localization to kinetochore (GO:0034501)2.88893447
76regulation of histone H3-K27 methylation (GO:0061085)2.88870283
77protein K6-linked ubiquitination (GO:0085020)2.88797520
78ribosome assembly (GO:0042255)2.88579568
79spliceosomal snRNP assembly (GO:0000387)2.86998419
80negative thymic T cell selection (GO:0045060)2.86232038
81viral life cycle (GO:0019058)2.85948724
82T cell migration (GO:0072678)2.84776263
83positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.83968398
84protein localization to chromosome (GO:0034502)2.83685559
85regulation of DNA endoreduplication (GO:0032875)2.83663826
86cellular protein complex disassembly (GO:0043624)2.81889567
87regulation of nuclear cell cycle DNA replication (GO:0033262)2.81103230
88positive regulation of granulocyte differentiation (GO:0030854)2.78571662
89spindle checkpoint (GO:0031577)2.78188121
90transcription-coupled nucleotide-excision repair (GO:0006283)2.77939510
91mitotic nuclear envelope disassembly (GO:0007077)2.77902503
92neutrophil activation involved in immune response (GO:0002283)2.77831433
93establishment of protein localization to endoplasmic reticulum (GO:0072599)2.77263073
94membrane disassembly (GO:0030397)2.75875381
95nuclear envelope disassembly (GO:0051081)2.75875381
96spliceosomal complex assembly (GO:0000245)2.75552055
97GMP metabolic process (GO:0046037)2.75290092
98ribosome biogenesis (GO:0042254)2.73105311
99exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.73095966
100protein localization to endoplasmic reticulum (GO:0070972)2.72482472
101tolerance induction (GO:0002507)2.72069768
102chromosome segregation (GO:0007059)2.71851047
103positive thymic T cell selection (GO:0045059)2.71515432
104DNA damage response, detection of DNA damage (GO:0042769)2.70511779
105nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.69973653
106establishment of chromosome localization (GO:0051303)2.69700464
107leukocyte aggregation (GO:0070486)2.69242803
108deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.69066618
109tRNA modification (GO:0006400)2.67968592
110pseudouridine synthesis (GO:0001522)2.67637973
111nuclear pore organization (GO:0006999)2.67520525
112protein localization to chromosome, centromeric region (GO:0071459)2.67079742
113intra-S DNA damage checkpoint (GO:0031573)2.66212632
114attachment of spindle microtubules to kinetochore (GO:0008608)2.65450491
115mitotic sister chromatid segregation (GO:0000070)2.65383517
116negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.64190748
117histone H3-K4 trimethylation (GO:0080182)2.64187005
118DNA replication-dependent nucleosome assembly (GO:0006335)2.64157218
119DNA replication-dependent nucleosome organization (GO:0034723)2.64157218
120histone H4 deacetylation (GO:0070933)2.62729596
121DNA-templated transcription, termination (GO:0006353)2.62286677
122histone mRNA catabolic process (GO:0071044)2.60756544
1237-methylguanosine mRNA capping (GO:0006370)2.60713885
124DNA-dependent DNA replication (GO:0006261)2.60562181
125positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.60373850
126mismatch repair (GO:0006298)2.60239188
127negative regulation of DNA-dependent DNA replication (GO:2000104)2.60170696
128mitotic spindle checkpoint (GO:0071174)2.59692359
129regulation of retinoic acid receptor signaling pathway (GO:0048385)2.59408034
130DNA deamination (GO:0045006)2.58817604
131RNA capping (GO:0036260)2.58507770
1327-methylguanosine RNA capping (GO:0009452)2.58507770
133nucleobase biosynthetic process (GO:0046112)2.57551155
134maturation of 5.8S rRNA (GO:0000460)2.57049000
135megakaryocyte development (GO:0035855)2.56262752
136ncRNA processing (GO:0034470)2.56108902
137histone H2B ubiquitination (GO:0033523)2.55698209
138T cell homeostasis (GO:0043029)2.55488727
139regulation of chromosome segregation (GO:0051983)2.55480837
140positive regulation of chromosome segregation (GO:0051984)2.54618202
141protein complex disassembly (GO:0043241)2.54140790
142nuclear-transcribed mRNA catabolic process (GO:0000956)2.53669724
143transcription from RNA polymerase I promoter (GO:0006360)2.51579963
144establishment of viral latency (GO:0019043)2.51412158
145RNA splicing, via transesterification reactions (GO:0000375)2.51338571
146DNA-templated transcription, elongation (GO:0006354)2.51011431
147regulation of spindle organization (GO:0090224)2.50925135
148RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.50327612
149mRNA splicing, via spliceosome (GO:0000398)2.50327612
150peptidyl-lysine trimethylation (GO:0018023)2.49757626
151T cell selection (GO:0045058)2.49570128
152B cell homeostasis (GO:0001782)2.46552436
153centriole replication (GO:0007099)2.45852272
154rRNA modification (GO:0000154)2.45684372
155anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.45141321
156regulation of sister chromatid cohesion (GO:0007063)2.44931631
157mRNA catabolic process (GO:0006402)2.44900439
158histone H3-K9 modification (GO:0061647)2.44774049
159cellular component biogenesis (GO:0044085)2.44610767
160alternative mRNA splicing, via spliceosome (GO:0000380)2.44487887
161RNA destabilization (GO:0050779)2.41201450
162negative regulation of chromosome segregation (GO:0051985)2.40159601
163intracellular estrogen receptor signaling pathway (GO:0030520)2.40101213
164negative regulation of lymphocyte mediated immunity (GO:0002707)2.40068596
165microtubule polymerization or depolymerization (GO:0031109)2.39535848
166non-recombinational repair (GO:0000726)2.39287687
167double-strand break repair via nonhomologous end joining (GO:0006303)2.39287687
168negative regulation of cell cycle G2/M phase transition (GO:1902750)2.37877326
169negative regulation of T cell mediated immunity (GO:0002710)2.37846489
170sister chromatid cohesion (GO:0007062)2.37731080
171thymic T cell selection (GO:0045061)2.36356798
172negative regulation of erythrocyte differentiation (GO:0045647)2.36009808
173negative regulation of sister chromatid segregation (GO:0033046)2.35851981
174negative regulation of mitotic sister chromatid segregation (GO:0033048)2.35851981

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.05990631
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.63028658
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.02309737
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.94359952
5* MYC_18555785_ChIP-Seq_MESCs_Mouse3.60606833
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.47181904
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.32521996
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.26038046
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.22571494
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.05926540
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.94669813
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.77960318
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.73934452
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.72759851
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.68693858
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.64412614
17* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.59822211
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.59140356
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53179314
20ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.52980858
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.52547905
22TP63_19390658_ChIP-ChIP_HaCaT_Human2.42229519
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.41333209
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.39438436
25MYC_18358816_ChIP-ChIP_MESCs_Mouse2.39401717
26VDR_23849224_ChIP-Seq_CD4+_Human2.28622524
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.27565244
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25809184
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.12526641
30* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.09296384
31IRF1_19129219_ChIP-ChIP_H3396_Human2.06961881
32FOXP3_21729870_ChIP-Seq_TREG_Human2.06825268
33MYB_26560356_Chip-Seq_TH2_Human2.01500884
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.00709666
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.97603945
36XRN2_22483619_ChIP-Seq_HELA_Human1.89687602
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88254585
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82699512
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.80357543
40TTF2_22483619_ChIP-Seq_HELA_Human1.80312777
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.80309604
42IRF8_22096565_ChIP-ChIP_GC-B_Human1.78995782
43DCP1A_22483619_ChIP-Seq_HELA_Human1.77240907
44MYB_26560356_Chip-Seq_TH1_Human1.72208418
45MAF_26560356_Chip-Seq_TH1_Human1.71949765
46ELK1_19687146_ChIP-ChIP_HELA_Human1.71864139
47IRF8_21731497_ChIP-ChIP_J774_Mouse1.71717180
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65479400
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.62794894
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62189457
51FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.62078892
52CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.61169781
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.59594254
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59355629
55KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.58528982
56KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.58528982
57KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.58528982
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.58086612
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57564308
60SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55347147
61* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54736588
62* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54126211
63VDR_21846776_ChIP-Seq_THP-1_Human1.53858345
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53542958
65* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53166042
66* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52995608
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51467989
68STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.51169799
69* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50780747
70UTX_26944678_Chip-Seq_JUKART_Human1.49809032
71* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45255211
72* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42489075
73RUNX_20019798_ChIP-Seq_JUKART_Human1.42207482
74TCF7_22412390_ChIP-Seq_EML_Mouse1.40264243
75* CIITA_25753668_ChIP-Seq_RAJI_Human1.39521731
76AR_21909140_ChIP-Seq_LNCAP_Human1.39219956
77GABP_19822575_ChIP-Seq_HepG2_Human1.37419534
78MYC_18940864_ChIP-ChIP_HL60_Human1.33958290
79RUNX1_22412390_ChIP-Seq_EML_Mouse1.33522022
80GATA3_27048872_Chip-Seq_THYMUS_Human1.32803358
81NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32677144
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31536923
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.31105589
84CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.31091713
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30234329
86MAF_26560356_Chip-Seq_TH2_Human1.29711571
87* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22912496
88SRF_21415370_ChIP-Seq_HL-1_Mouse1.22366687
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21835528
90MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19652177
91E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18853937
92IRF8_27001747_Chip-Seq_BMDM_Mouse1.18517572
93STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16739956
94KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14839304
95* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14749833
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14205644
97* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13871827
98PKCTHETA_26484144_Chip-Seq_BREAST_Human1.11040765
99PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10768468
100BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08993578
101SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08711277
102TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06975420
103EWS_26573619_Chip-Seq_HEK293_Human1.06492064
104SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06035360
105SOX2_16153702_ChIP-ChIP_HESCs_Human1.05169982
106PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05105937
107TFEB_21752829_ChIP-Seq_HELA_Human1.04715406
108KDM5A_27292631_Chip-Seq_BREAST_Human1.04557534
109SPI1_23127762_ChIP-Seq_K562_Human1.03867860
110FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00738091
111PU_27001747_Chip-Seq_BMDM_Mouse1.00173780
112FLI1_27457419_Chip-Seq_LIVER_Mouse0.99988328
113PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99801731
114SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99133175
115ELK1_22589737_ChIP-Seq_MCF10A_Human0.98384096
116GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97445182
117E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97138746
118* KDM2B_26808549_Chip-Seq_DND41_Human0.96636318
119SPI1_23547873_ChIP-Seq_NB4_Human0.88825305
120CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86507831
121NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.84289268
122SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82961507
123SALL1_21062744_ChIP-ChIP_HESCs_Human0.82513436
124* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.78817980
125CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.75672994
126PCGF2_27294783_Chip-Seq_NPCs_Mouse0.73097982
127* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.71971121
128FUS_26573619_Chip-Seq_HEK293_Human0.71202332
129GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.71027157
130IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.69403048
131NANOG_16153702_ChIP-ChIP_HESCs_Human0.67337027
132SCL_19346495_ChIP-Seq_HPC-7_Human0.66818526
133NFE2_27457419_Chip-Seq_LIVER_Mouse0.65987577
134* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.64738232
135MYC_22102868_ChIP-Seq_BL_Human0.61089079
136* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.60611190
137FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.60423234
138SUZ12_27294783_Chip-Seq_NPCs_Mouse0.58498971
139CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.58045201

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.27827714
2MP0003693_abnormal_embryo_hatching4.09825572
3MP0008057_abnormal_DNA_replication3.50216798
4MP0010094_abnormal_chromosome_stability3.18673707
5MP0003111_abnormal_nucleus_morphology3.11895384
6MP0006292_abnormal_olfactory_placode3.05998217
7MP0004957_abnormal_blastocyst_morpholog2.78896636
8MP0003077_abnormal_cell_cycle2.68548994
9MP0004381_abnormal_hair_follicle2.66920448
10MP0001188_hyperpigmentation2.64862599
11MP0008058_abnormal_DNA_repair2.63248744
12MP0001835_abnormal_antigen_presentation2.57911810
13MP0003303_peritoneal_inflammation2.28842580
14MP0003656_abnormal_erythrocyte_physiolo2.28375195
15MP0009278_abnormal_bone_marrow2.24448470
16MP0000569_abnormal_digit_pigmentation2.20861258
17MP0005409_darkened_coat_color2.19993077
18MP0003221_abnormal_cardiomyocyte_apopto2.12767041
19MP0003646_muscle_fatigue2.07643565
20MP0008932_abnormal_embryonic_tissue2.05065167
21MP0003718_maternal_effect1.97870869
22MP0008007_abnormal_cellular_replicative1.96808452
23MP0005397_hematopoietic_system_phenotyp1.87962312
24MP0001545_abnormal_hematopoietic_system1.87962312
25MP0003436_decreased_susceptibility_to1.72978402
26MP0000566_synostosis1.70862104
27MP0003315_abnormal_perineum_morphology1.68802678
28MP0002723_abnormal_immune_serum1.67002357
29MP0008260_abnormal_autophagy1.66617934
30MP0003763_abnormal_thymus_physiology1.66213558
31MP0005310_abnormal_salivary_gland1.66007307
32MP0003938_abnormal_ear_development1.64631562
33MP0009379_abnormal_foot_pigmentation1.63331698
34MP0002009_preneoplasia1.61491603
35MP0002396_abnormal_hematopoietic_system1.58392700
36MP0002102_abnormal_ear_morphology1.58010867
37MP0005000_abnormal_immune_tolerance1.54485411
38MP0002653_abnormal_ependyma_morphology1.54444687
39MP0003724_increased_susceptibility_to1.51010438
40MP0003786_premature_aging1.50994722
41MP0009333_abnormal_splenocyte_physiolog1.46994363
42MP0008877_abnormal_DNA_methylation1.44048910
43MP0003937_abnormal_limbs/digits/tail_de1.42800437
44MP0002405_respiratory_system_inflammati1.41712350
45MP0005451_abnormal_body_composition1.39179753
46MP0003787_abnormal_imprinting1.38316125
47MP0002638_abnormal_pupillary_reflex1.34038650
48MP0002132_abnormal_respiratory_system1.33517755
49MP0003880_abnormal_central_pattern1.30463484
50MP0001293_anophthalmia1.30311322
51MP0004185_abnormal_adipocyte_glucose1.29833195
52MP0002163_abnormal_gland_morphology1.29581173
53* MP0000350_abnormal_cell_proliferation1.29220477
54MP0002419_abnormal_innate_immunity1.28526255
55MP0000490_abnormal_crypts_of1.28307256
56MP0000015_abnormal_ear_pigmentation1.27387196
57MP0002938_white_spotting1.25973862
58MP0005174_abnormal_tail_pigmentation1.24357980
59MP0003172_abnormal_lysosome_physiology1.22509113
60MP0005387_immune_system_phenotype1.21331615
61MP0001790_abnormal_immune_system1.21331615
62MP0005025_abnormal_response_to1.20890512
63MP0006054_spinal_hemorrhage1.19917032
64MP0000383_abnormal_hair_follicle1.19896843
65MP0000049_abnormal_middle_ear1.17049251
66MP0002751_abnormal_autonomic_nervous1.15780494
67MP0002277_abnormal_respiratory_mucosa1.15595667
68MP0001853_heart_inflammation1.14054433
69MP0010307_abnormal_tumor_latency1.13325511
70MP0001730_embryonic_growth_arrest1.12392634
71MP0000465_gastrointestinal_hemorrhage1.10267887
72MP0002095_abnormal_skin_pigmentation1.09665745
73MP0003941_abnormal_skin_development1.08466222
74MP0000703_abnormal_thymus_morphology1.07812689
75MP0003943_abnormal_hepatobiliary_system1.04916189
76MP0002210_abnormal_sex_determination1.04372650
77MP0002085_abnormal_embryonic_tissue1.02913813
78MP0001286_abnormal_eye_development1.02871036
79MP0004147_increased_porphyrin_level1.02335736
80MP0002398_abnormal_bone_marrow1.01989746
81MP0003121_genomic_imprinting1.00749326
82MP0005671_abnormal_response_to1.00701887
83MP0005076_abnormal_cell_differentiation0.99790832
84MP0005248_abnormal_Harderian_gland0.99196614
85MP0005075_abnormal_melanosome_morpholog0.97204626
86MP0000685_abnormal_immune_system0.95188265
87MP0004742_abnormal_vestibular_system0.93092520
88MP0002138_abnormal_hepatobiliary_system0.90805267
89MP0010030_abnormal_orbit_morphology0.90135885
90MP0003984_embryonic_growth_retardation0.89135289
91MP0002722_abnormal_immune_system0.87987795
92MP0001672_abnormal_embryogenesis/_devel0.87922784
93MP0005380_embryogenesis_phenotype0.87922784
94MP0009785_altered_susceptibility_to0.87677611
95MP0001697_abnormal_embryo_size0.87468026
96MP0002019_abnormal_tumor_incidence0.86957750
97MP0002148_abnormal_hypersensitivity_rea0.86673044
98* MP0006035_abnormal_mitochondrial_morpho0.86403028
99MP0008789_abnormal_olfactory_epithelium0.86337057
100MP0000689_abnormal_spleen_morphology0.86243973
101MP0002088_abnormal_embryonic_growth/wei0.86194023
102MP0006072_abnormal_retinal_apoptosis0.85614501
103MP0004233_abnormal_muscle_weight0.85596833
104MP0000313_abnormal_cell_death0.85327615
105MP0003123_paternal_imprinting0.85237105
106MP0000631_abnormal_neuroendocrine_gland0.83769627
107MP0001929_abnormal_gametogenesis0.83102202
108MP0001145_abnormal_male_reproductive0.83013708
109MP0005171_absent_coat_pigmentation0.81650654
110MP0001529_abnormal_vocalization0.80132160
111MP0002249_abnormal_larynx_morphology0.80039682
112MP0000432_abnormal_head_morphology0.77921431
113MP0002177_abnormal_outer_ear0.77541422
114* MP0002080_prenatal_lethality0.77170336
115MP0002086_abnormal_extraembryonic_tissu0.76995763
116MP0001800_abnormal_humoral_immune0.76907990
117MP0003861_abnormal_nervous_system0.76552288
118MP0004197_abnormal_fetal_growth/weight/0.76380805
119MP0004808_abnormal_hematopoietic_stem0.76202205
120MP0001485_abnormal_pinna_reflex0.74926678
121MP0002420_abnormal_adaptive_immunity0.74696191
122MP0005621_abnormal_cell_physiology0.74611947
123MP0000716_abnormal_immune_system0.74360391
124MP0001819_abnormal_immune_cell0.73565433
125MP0000647_abnormal_sebaceous_gland0.73539591
126MP0005391_vision/eye_phenotype0.73373401
127MP0002084_abnormal_developmental_patter0.72992671
128MP0000653_abnormal_sex_gland0.72865107
129MP0002429_abnormal_blood_cell0.72209312
130MP0003567_abnormal_fetal_cardiomyocyte0.71836615
131MP0003755_abnormal_palate_morphology0.71607831
132MP0010155_abnormal_intestine_physiology0.71186577
133MP0000372_irregular_coat_pigmentation0.70603778
134MP0009250_abnormal_appendicular_skeleto0.70534290
135MP0001919_abnormal_reproductive_system0.70378453
136MP0002092_abnormal_eye_morphology0.69864376
137MP0003119_abnormal_digestive_system0.68730409
138MP0005379_endocrine/exocrine_gland_phen0.67554424
139MP0003890_abnormal_embryonic-extraembry0.67372570
140MP0002452_abnormal_antigen_presenting0.67341426
141MP0009115_abnormal_fat_cell0.66846741
142MP0004133_heterotaxia0.66643660
143* MP0005384_cellular_phenotype0.65910553
144MP0000026_abnormal_inner_ear0.65620701
145MP0008995_early_reproductive_senescence0.65157733
146MP0001845_abnormal_inflammatory_respons0.64368038
147MP0000858_altered_metastatic_potential0.63450378
148MP0005666_abnormal_adipose_tissue0.63410549

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)4.94912850
2Abnormality of the fingertips (HP:0001211)4.28584034
3Nasal polyposis (HP:0100582)4.11669663
4Progressive external ophthalmoplegia (HP:0000590)4.03538931
5Recurrent bacterial skin infections (HP:0005406)3.83730051
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.72184033
7Birth length less than 3rd percentile (HP:0003561)3.68196942
8Chromsome breakage (HP:0040012)3.58036910
9Reticulocytopenia (HP:0001896)3.57852586
10Abnormality of cells of the erythroid lineage (HP:0012130)3.54554272
11Recurrent abscess formation (HP:0002722)3.31003179
12Abnormal number of erythroid precursors (HP:0012131)3.28589856
13Recurrent bronchitis (HP:0002837)3.21850807
14Abnormality of the nasal mucosa (HP:0000433)3.12484040
15Breast hypoplasia (HP:0003187)3.12046502
16Chronic sinusitis (HP:0011109)3.09675638
17Patellar aplasia (HP:0006443)2.98769578
18IgM deficiency (HP:0002850)2.92791202
19Panhypogammaglobulinemia (HP:0003139)2.88049270
20Supernumerary spleens (HP:0009799)2.86346678
21Abnormal lung lobation (HP:0002101)2.86264414
22Deep palmar crease (HP:0006191)2.84165074
23Aplasia/Hypoplasia of the patella (HP:0006498)2.81182658
24Absent rod-and cone-mediated responses on ERG (HP:0007688)2.78578055
25Macrocytic anemia (HP:0001972)2.70723365
26Duplicated collecting system (HP:0000081)2.68613352
27Absent radius (HP:0003974)2.68036531
28Abnormality of the preputium (HP:0100587)2.65618486
29Meckel diverticulum (HP:0002245)2.63686645
30Aplasia involving forearm bones (HP:0009822)2.63008822
31Absent forearm bone (HP:0003953)2.63008822
32Eczematoid dermatitis (HP:0000976)2.60777874
33Abnormality of lateral ventricle (HP:0030047)2.57177452
34Abnormality of the ileum (HP:0001549)2.52843469
35Impaired proprioception (HP:0010831)2.51317497
36Recurrent viral infections (HP:0004429)2.51241564
37Combined immunodeficiency (HP:0005387)2.51185168
38Increased density of long bones (HP:0006392)2.47360598
39Severe combined immunodeficiency (HP:0004430)2.44629031
40Ectopic kidney (HP:0000086)2.44477368
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.43028178
42Basal cell carcinoma (HP:0002671)2.41143655
43Hypochromic microcytic anemia (HP:0004840)2.37636532
44Asplenia (HP:0001746)2.37165479
45Volvulus (HP:0002580)2.36788842
46Cafe-au-lait spot (HP:0000957)2.36063750
47Bronchitis (HP:0012387)2.35753266
48Disinhibition (HP:0000734)2.35224478
49Pallor (HP:0000980)2.34623155
50Cerebral hypomyelination (HP:0006808)2.31156656
51Abnormality of the renal collecting system (HP:0004742)2.31040386
52Triphalangeal thumb (HP:0001199)2.30787619
53Aplasia/Hypoplasia of the sacrum (HP:0008517)2.29894799
54Lymphopenia (HP:0001888)2.29531070
55Bronchiectasis (HP:0002110)2.29387477
56Abnormality of chromosome stability (HP:0003220)2.28036415
57Impulsivity (HP:0100710)2.27906900
58Encephalitis (HP:0002383)2.24328893
59Cleft eyelid (HP:0000625)2.24287813
60Progressive muscle weakness (HP:0003323)2.23186110
61Abnormality of the left ventricular outflow tract (HP:0011103)2.21932277
62Subaortic stenosis (HP:0001682)2.21932277
63Agnosia (HP:0010524)2.21010112
64T lymphocytopenia (HP:0005403)2.20910619
65Recurrent sinusitis (HP:0011108)2.18662808
66Microvesicular hepatic steatosis (HP:0001414)2.18139063
67Dyschromatopsia (HP:0007641)2.17909124
68Duplication of thumb phalanx (HP:0009942)2.17577563
69Abnormality of the axillary hair (HP:0100134)2.17410655
70Abnormality of secondary sexual hair (HP:0009888)2.17410655
71Abnormal rod and cone electroretinograms (HP:0008323)2.17256722
72Abnormality of the columella (HP:0009929)2.17010442
73Hypoplasia of the radius (HP:0002984)2.16537606
74Bone marrow hypocellularity (HP:0005528)2.15839413
75Absent thumb (HP:0009777)2.15421906
76Aplasia/Hypoplasia of the spleen (HP:0010451)2.14791879
77Fatigue (HP:0012378)2.14760884
7811 pairs of ribs (HP:0000878)2.14392483
79Hypoplastic iliac wings (HP:0002866)2.12124509
80Abnormal number of incisors (HP:0011064)2.12075481
81Chin dimple (HP:0010751)2.10820765
82Recurrent fungal infections (HP:0002841)2.07647345
83Type I transferrin isoform profile (HP:0003642)2.07416945
84Abnormality of cells of the lymphoid lineage (HP:0012140)2.06709045
85Osteomyelitis (HP:0002754)2.04745591
86Stenosis of the external auditory canal (HP:0000402)2.04441082
87Duodenal stenosis (HP:0100867)2.03788895
88Small intestinal stenosis (HP:0012848)2.03788895
89Optic neuritis (HP:0100653)2.03426943
90Retrobulbar optic neuritis (HP:0100654)2.03426943
91Mediastinal lymphadenopathy (HP:0100721)2.03245824
92Granulocytopenia (HP:0001913)2.02627914
93Progressive inability to walk (HP:0002505)2.02196956
94Rough bone trabeculation (HP:0100670)2.00314502
95Anhidrosis (HP:0000970)2.00055019
96Abnormality of the septum pellucidum (HP:0007375)1.99931320
97Spontaneous hematomas (HP:0007420)1.99463894
98Short thumb (HP:0009778)1.99363854
99Myelodysplasia (HP:0002863)1.99146264
100Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.98965089
101Abnormal sex determination (HP:0012244)1.98431667
102Sex reversal (HP:0012245)1.98431667
103Selective tooth agenesis (HP:0001592)1.96943880
104Parakeratosis (HP:0001036)1.96617539
105Neoplasm of the adrenal cortex (HP:0100641)1.95917940
106Prominent nose (HP:0000448)1.95861948
107Meningitis (HP:0001287)1.95560745
108Abnormal delayed hypersensitivity skin test (HP:0002963)1.95328703
109Nephroblastoma (Wilms tumor) (HP:0002667)1.93332379
110Ragged-red muscle fibers (HP:0003200)1.93070842
111Embryonal renal neoplasm (HP:0011794)1.90239029
112Carpal bone hypoplasia (HP:0001498)1.89549719
113Acute myeloid leukemia (HP:0004808)1.89542018
114Recurrent skin infections (HP:0001581)1.88699306
115Myositis (HP:0100614)1.88029945
116Absent septum pellucidum (HP:0001331)1.87929894
117Agammaglobulinemia (HP:0004432)1.87068562
118Eosinophilia (HP:0001880)1.86782025
119Abnormality of T cell number (HP:0011839)1.85968332
120Elevated erythrocyte sedimentation rate (HP:0003565)1.85276523
121Leukocytosis (HP:0001974)1.83712655
122Premature graying of hair (HP:0002216)1.82742786
1233-Methylglutaconic aciduria (HP:0003535)1.81186335
124Acute hepatic failure (HP:0006554)1.80988090
125Dysphonia (HP:0001618)1.80641495
126Aplasia/Hypoplasia of the sternum (HP:0006714)1.79710252
127Abnormality of eosinophils (HP:0001879)1.78774207
128Lymphoma (HP:0002665)1.78748443
129Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.78584937
130Medulloblastoma (HP:0002885)1.78570470
131Aplasia/Hypoplasia of the earlobes (HP:0009906)1.78445525
132Deep philtrum (HP:0002002)1.78323097
133Preaxial hand polydactyly (HP:0001177)1.78091752
134Cellular immunodeficiency (HP:0005374)1.78085872
135Facial cleft (HP:0002006)1.77949798
136Atresia of the external auditory canal (HP:0000413)1.77849396
137Midline defect of the nose (HP:0004122)1.77531652
138Cupped ear (HP:0000378)1.77432625
139Abnormal respiratory epithelium morphology (HP:0012253)1.77363590
140Abnormal respiratory motile cilium morphology (HP:0005938)1.77363590
141Absent eyebrow (HP:0002223)1.76809033
142Horseshoe kidney (HP:0000085)1.75620370
143Capillary hemangiomas (HP:0005306)1.75528338
144Abnormality of macrophages (HP:0004311)1.75423423
145Abnormal hair whorl (HP:0010721)1.75256674
146Intestinal atresia (HP:0011100)1.75018157
147Septo-optic dysplasia (HP:0100842)1.74655743
148Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.74489999
149Slow saccadic eye movements (HP:0000514)1.73550881
150Decreased central vision (HP:0007663)1.73437987
151Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.73170680
152Keratoconjunctivitis sicca (HP:0001097)1.73136609
153Progressive hearing impairment (HP:0001730)1.72461015
154Abnormality of the labia minora (HP:0012880)1.72339950
155Orchitis (HP:0100796)1.72152401
156Partial duplication of thumb phalanx (HP:0009944)1.72056006
157Sparse lateral eyebrow (HP:0005338)1.72049227
158Clubbing of toes (HP:0100760)1.71103710
159Abnormality of the duodenum (HP:0002246)1.71012093
160Oligodactyly (hands) (HP:0001180)1.70585382
161Pustule (HP:0200039)1.70526035
162Abnormality of T cells (HP:0002843)1.70481781
163Optic nerve coloboma (HP:0000588)1.68544507
164Sloping forehead (HP:0000340)1.68091602
165Short middle phalanx of the 5th finger (HP:0004220)1.67792381
166Amaurosis fugax (HP:0100576)1.67636852
167Rhabdomyosarcoma (HP:0002859)1.66374606
168Adrenal hypoplasia (HP:0000835)1.66040952
169Anophthalmia (HP:0000528)1.66019468
170Concave nail (HP:0001598)1.65683305
171CNS hypomyelination (HP:0003429)1.65657464
172Abnormality of the lacrimal duct (HP:0011481)1.65025170
173Abnormality of DNA repair (HP:0003254)1.64999213
174Pancreatic cysts (HP:0001737)1.61204444
175Tracheoesophageal fistula (HP:0002575)1.60911577
176Rib fusion (HP:0000902)1.60802694
177Hypoplastic pelvis (HP:0008839)1.59834012
178Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.59313927
179Abnormality of abdominal situs (HP:0011620)1.58089813
180Abdominal situs inversus (HP:0003363)1.58089813
181Supernumerary bones of the axial skeleton (HP:0009144)1.57409390
182True hermaphroditism (HP:0010459)1.57194904
183Stomatitis (HP:0010280)1.56712188
184Prolonged neonatal jaundice (HP:0006579)1.55945141
185Neoplasm of the pancreas (HP:0002894)1.55258573

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.19393684
2MAP3K133.93873408
3NEK13.29754697
4WEE12.96537228
5SRPK12.76895609
6CASK2.75318197
7AKT32.63150171
8ACVR1B2.50639299
9MKNK22.48994865
10TAOK12.34041608
11MKNK12.33940171
12CDC72.32180379
13STK162.22222722
14VRK12.20601950
15TLK12.15968910
16NME22.11238109
17CLK12.03604518
18MAP3K102.01693312
19NLK1.94612841
20MAP2K31.91465578
21MARK31.87657198
22EIF2AK11.78687232
23TTK1.77002876
24NEK21.72670791
25MAP3K141.72397423
26BRSK11.71642826
27DYRK31.68293804
28TNK21.60641056
29PLK41.54291027
30BRAF1.50593576
31TAOK31.50590826
32MUSK1.50044021
33TNIK1.49395220
34EIF2AK31.46565021
35RIPK41.45899308
36EIF2AK21.45143286
37SIK31.42074223
38PBK1.40830274
39CDK71.36366466
40TSSK61.36020939
41PLK11.33908569
42STK101.31387392
43YES11.30713486
44BMPR1B1.30400765
45KSR21.30302089
46TXK1.29273778
47CSK1.28991700
48BLK1.27216110
49BRSK21.25703079
50AURKB1.20942994
51CHEK21.19573939
52DYRK21.18192982
53CSNK1G11.17401143
54MST41.17168338
55FGR1.15894772
56FES1.15784719
57SMG11.15110205
58RPS6KA51.14370692
59MARK21.13815493
60TYK21.09751132
61AURKA1.07469827
62MAP4K11.05768954
63CDK41.05661894
64PASK1.05350423
65HCK1.02792654
66IRAK41.02418499
67MELK1.01415516
68PNCK0.99865808
69TESK20.95901181
70ATR0.93166506
71PIM10.92923990
72STK40.91403503
73MAP3K60.90387171
74STK38L0.90199215
75STK390.89211334
76PLK30.87883698
77BRD40.87513972
78EEF2K0.85099209
79CDK60.81569766
80CHEK10.79789483
81IRAK30.79698174
82ZAK0.79454281
83CSNK1G30.77354651
84MAP2K40.77261134
85RAF10.76346466
86CDK30.75843645
87CDK190.74072916
88MAPK150.72317618
89MAP3K70.71127002
90RPS6KA40.71009683
91MAP3K50.68962718
92MAP3K80.68318566
93PAK10.68177806
94CAMK1D0.67777486
95CDK120.66916164
96JAK20.65487701
97PRPF4B0.64943925
98NUAK10.64689933
99MAP3K110.64216924
100RPS6KB20.63940876
101CAMK40.63763430
102GRK60.63232613
103CSNK1A1L0.62829008
104TGFBR10.61619777
105KSR10.61472633
106IRAK10.60580049
107CDK80.59458890
108MAP3K10.59438575
109IRAK20.57244085
110ATM0.56916391
111MAP3K30.56455580
112CSNK2A20.54152489
113TEC0.53666943
114EPHA20.53655231
115CHUK0.53311915
116BTK0.53181277
117CDK20.53052549
118CSNK2A10.51354802
119PRKD20.50874783
120CDK10.50820758
121GRK10.49983918
122ADRBK20.49357937
123MAPKAPK50.48294579
124CAMKK20.48240047
125LYN0.48155172
126UHMK10.47936013
127WNK10.47538657
128DYRK1A0.47197979
129JAK30.46579604
130SYK0.46380263
131NME10.46068242
132MAP2K70.45934471
133CDK90.45811943
134KDR0.45796552
135NEK90.45687014
136MAPK110.44810873
137NEK60.43508183
138BMPR20.43311564
139CCNB10.43217707
140ITK0.43095041
141ZAP700.42794752
142DYRK1B0.41526452
143PRKCI0.41394673
144ICK0.41053424
145EPHB10.40846799
146PIM20.38846689
147LCK0.38121868
148SGK20.36247480
149MAPK130.36025666
150GRK70.35089356
151IKBKB0.34530137

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.67511723
2Ribosome_Homo sapiens_hsa030103.49130607
3RNA polymerase_Homo sapiens_hsa030203.44722483
4Mismatch repair_Homo sapiens_hsa034303.21178218
5Spliceosome_Homo sapiens_hsa030403.03106951
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.95369306
7Homologous recombination_Homo sapiens_hsa034402.85752187
8Fanconi anemia pathway_Homo sapiens_hsa034602.55875610
9Base excision repair_Homo sapiens_hsa034102.50174625
10Proteasome_Homo sapiens_hsa030502.37604117
11Nucleotide excision repair_Homo sapiens_hsa034202.34754963
12Non-homologous end-joining_Homo sapiens_hsa034502.26780387
13Cell cycle_Homo sapiens_hsa041102.26706916
14RNA transport_Homo sapiens_hsa030132.26090234
15Basal transcription factors_Homo sapiens_hsa030222.19766274
16Pyrimidine metabolism_Homo sapiens_hsa002402.16763895
17Osteoclast differentiation_Homo sapiens_hsa043801.98160898
18RNA degradation_Homo sapiens_hsa030181.72422510
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.65449447
20mRNA surveillance pathway_Homo sapiens_hsa030151.58852967
21Non-small cell lung cancer_Homo sapiens_hsa052231.55454459
22Chronic myeloid leukemia_Homo sapiens_hsa052201.45707226
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45555172
24Leishmaniasis_Homo sapiens_hsa051401.45108107
25Vitamin B6 metabolism_Homo sapiens_hsa007501.42961891
26Primary immunodeficiency_Homo sapiens_hsa053401.41600294
27Pancreatic cancer_Homo sapiens_hsa052121.40214154
28One carbon pool by folate_Homo sapiens_hsa006701.40170792
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37049478
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36091862
31Systemic lupus erythematosus_Homo sapiens_hsa053221.33460733
32p53 signaling pathway_Homo sapiens_hsa041151.32088465
33Purine metabolism_Homo sapiens_hsa002301.29155411
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26555994
35Viral myocarditis_Homo sapiens_hsa054161.17828223
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16007823
37Epstein-Barr virus infection_Homo sapiens_hsa051691.14450999
38FoxO signaling pathway_Homo sapiens_hsa040681.14325818
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12669049
40Endometrial cancer_Homo sapiens_hsa052131.09608561
41Tuberculosis_Homo sapiens_hsa051521.03657808
42Chemokine signaling pathway_Homo sapiens_hsa040621.03440741
43Ether lipid metabolism_Homo sapiens_hsa005651.01161022
44Herpes simplex infection_Homo sapiens_hsa051680.98904034
45Shigellosis_Homo sapiens_hsa051310.96121234
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94900069
47Protein export_Homo sapiens_hsa030600.94806903
48Basal cell carcinoma_Homo sapiens_hsa052170.92984135
49TNF signaling pathway_Homo sapiens_hsa046680.88912271
50VEGF signaling pathway_Homo sapiens_hsa043700.87534815
51NF-kappa B signaling pathway_Homo sapiens_hsa040640.87380021
52Legionellosis_Homo sapiens_hsa051340.86055430
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85980963
54Measles_Homo sapiens_hsa051620.84862772
55Hematopoietic cell lineage_Homo sapiens_hsa046400.82649061
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.82581841
57Autoimmune thyroid disease_Homo sapiens_hsa053200.82234891
58Sphingolipid metabolism_Homo sapiens_hsa006000.81937447
59Hepatitis C_Homo sapiens_hsa051600.80064956
60Lysine degradation_Homo sapiens_hsa003100.79852683
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.79802677
62Graft-versus-host disease_Homo sapiens_hsa053320.79102215
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78619815
64Phototransduction_Homo sapiens_hsa047440.77659645
65Viral carcinogenesis_Homo sapiens_hsa052030.77388795
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.74396812
67Alcoholism_Homo sapiens_hsa050340.72946869
68Toxoplasmosis_Homo sapiens_hsa051450.72404880
69Inositol phosphate metabolism_Homo sapiens_hsa005620.70085381
70Allograft rejection_Homo sapiens_hsa053300.69511439
71Prolactin signaling pathway_Homo sapiens_hsa049170.68911993
72Circadian rhythm_Homo sapiens_hsa047100.67498218
73Arachidonic acid metabolism_Homo sapiens_hsa005900.67395613
74Dorso-ventral axis formation_Homo sapiens_hsa043200.67030717
75mTOR signaling pathway_Homo sapiens_hsa041500.66039278
76Hedgehog signaling pathway_Homo sapiens_hsa043400.64322975
77MicroRNAs in cancer_Homo sapiens_hsa052060.64101229
78Asthma_Homo sapiens_hsa053100.64089565
79HTLV-I infection_Homo sapiens_hsa051660.63827017
80ErbB signaling pathway_Homo sapiens_hsa040120.63480788
81Antigen processing and presentation_Homo sapiens_hsa046120.63270408
82Prostate cancer_Homo sapiens_hsa052150.62668727
83Wnt signaling pathway_Homo sapiens_hsa043100.62568014
84Adherens junction_Homo sapiens_hsa045200.61074621
85Type I diabetes mellitus_Homo sapiens_hsa049400.60684251
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60522118
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58663783
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58254020
89Thyroid cancer_Homo sapiens_hsa052160.57501450
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57135071
91Colorectal cancer_Homo sapiens_hsa052100.56751314
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56400401
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56358207
94Glioma_Homo sapiens_hsa052140.56077477
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56008368
96Oocyte meiosis_Homo sapiens_hsa041140.55858748
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55613579
98HIF-1 signaling pathway_Homo sapiens_hsa040660.54507326
99T cell receptor signaling pathway_Homo sapiens_hsa046600.54436382
100Choline metabolism in cancer_Homo sapiens_hsa052310.53049997
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52570122
102Bladder cancer_Homo sapiens_hsa052190.51053011
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49811897
104Folate biosynthesis_Homo sapiens_hsa007900.49761396
105Notch signaling pathway_Homo sapiens_hsa043300.48665843
106Pathways in cancer_Homo sapiens_hsa052000.48435038
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48416094
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48395097
109Linoleic acid metabolism_Homo sapiens_hsa005910.48196955
110Olfactory transduction_Homo sapiens_hsa047400.47851116
111MAPK signaling pathway_Homo sapiens_hsa040100.47421941
112Staphylococcus aureus infection_Homo sapiens_hsa051500.47000593
113Huntingtons disease_Homo sapiens_hsa050160.45813200
114Small cell lung cancer_Homo sapiens_hsa052220.45365281
115Regulation of autophagy_Homo sapiens_hsa041400.41664885
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41620533
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.40876287
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40684711
119Oxidative phosphorylation_Homo sapiens_hsa001900.40073603
120Acute myeloid leukemia_Homo sapiens_hsa052210.39981208
121Hippo signaling pathway_Homo sapiens_hsa043900.39298462
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37885725
123Sulfur relay system_Homo sapiens_hsa041220.37079020
124TGF-beta signaling pathway_Homo sapiens_hsa043500.34188913
125Malaria_Homo sapiens_hsa051440.33093355
126B cell receptor signaling pathway_Homo sapiens_hsa046620.32734061
127Hepatitis B_Homo sapiens_hsa051610.32354024
128Other glycan degradation_Homo sapiens_hsa005110.30944693
129Melanoma_Homo sapiens_hsa052180.30899643
130Apoptosis_Homo sapiens_hsa042100.29972731
131Renal cell carcinoma_Homo sapiens_hsa052110.28804303
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28142698
133RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26878900
134Axon guidance_Homo sapiens_hsa043600.26730019
135Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25752534
136Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25693738
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.23961358
138Parkinsons disease_Homo sapiens_hsa050120.23791586
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23589007
140Influenza A_Homo sapiens_hsa051640.23403686
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21620429
142PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19958022
143Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19569582

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