NRG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurofilament cytoskeleton organization (GO:0060052)7.29475203
2cell adhesion mediated by integrin (GO:0033627)7.10907940
3negative regulation of dendrite morphogenesis (GO:0050774)6.39109220
4peripheral nervous system neuron development (GO:0048935)5.80669324
5cell-substrate junction assembly (GO:0007044)5.75491037
6negative regulation of keratinocyte proliferation (GO:0010839)5.60248276
7cell migration in hindbrain (GO:0021535)5.49763555
8desmosome organization (GO:0002934)5.22178226
9endodermal cell differentiation (GO:0035987)5.16495963
10detection of temperature stimulus involved in sensory perception of pain (GO:0050965)5.05184642
11detection of temperature stimulus involved in sensory perception (GO:0050961)5.05184642
12detection of temperature stimulus (GO:0016048)4.92661668
13mesodermal cell differentiation (GO:0048333)4.78570098
14cellular response to vitamin D (GO:0071305)4.77860535
15dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.56875768
16substrate-dependent cell migration (GO:0006929)4.48400535
17negative regulation of dendrite development (GO:2000171)4.45150218
18artery development (GO:0060840)4.14039750
19heparan sulfate proteoglycan biosynthetic process (GO:0015012)4.13268746
20regulation of NFAT protein import into nucleus (GO:0051532)4.11331864
21cellular response to vitamin (GO:0071295)3.99335565
22keratinocyte proliferation (GO:0043616)3.97998633
23negative regulation of homotypic cell-cell adhesion (GO:0034111)3.91332608
24ganglion development (GO:0061548)3.85535106
25innervation (GO:0060384)3.81468470
26negative regulation of axon extension involved in axon guidance (GO:0048843)3.73697778
27axon extension involved in axon guidance (GO:0048846)3.69590746
28neuron projection extension involved in neuron projection guidance (GO:1902284)3.69590746
29regulation of dendritic cell antigen processing and presentation (GO:0002604)3.69001743
30skin morphogenesis (GO:0043589)3.68991190
31regulation of keratinocyte proliferation (GO:0010837)3.65502141
32negative regulation of chondrocyte differentiation (GO:0032331)3.62336117
33type B pancreatic cell proliferation (GO:0044342)3.55688694
34chondrocyte proliferation (GO:0035988)3.54488726
35regulation of axon extension involved in axon guidance (GO:0048841)3.53525559
36intermediate filament organization (GO:0045109)3.49168624
37negative regulation of calcium ion transport into cytosol (GO:0010523)3.48859022
38lymphangiogenesis (GO:0001946)3.47702026
39axon extension (GO:0048675)3.40328012
40lateral sprouting from an epithelium (GO:0060601)3.38801939
41neuronal action potential (GO:0019228)3.37586531
42neuronal action potential propagation (GO:0019227)3.36117830
43cell migration involved in sprouting angiogenesis (GO:0002042)3.32668227
44cellular response to ATP (GO:0071318)3.28594529
45regulation of synaptic vesicle exocytosis (GO:2000300)3.27297016
46negative chemotaxis (GO:0050919)3.26088521
47negative regulation of axon guidance (GO:1902668)3.26022395
48regulation of axon guidance (GO:1902667)3.25049984
49serotonin receptor signaling pathway (GO:0007210)3.23840288
50neuron cell-cell adhesion (GO:0007158)3.22144120
51facial nerve structural organization (GO:0021612)3.21910204
52heparan sulfate proteoglycan metabolic process (GO:0030201)3.21412635
53calcium-mediated signaling using intracellular calcium source (GO:0035584)3.20437783
54negative regulation of microtubule polymerization (GO:0031115)3.19272076
55wound healing, spreading of epidermal cells (GO:0035313)3.18131666
56regulation of transforming growth factor beta2 production (GO:0032909)3.17026296
57DNA damage induced protein phosphorylation (GO:0006975)3.16776005
58response to prostaglandin E (GO:0034695)3.16267415
59positive regulation of monocyte chemotaxis (GO:0090026)3.12488191
60response to acidic pH (GO:0010447)3.10790079
61synaptic vesicle exocytosis (GO:0016079)3.09201047
62pericardium development (GO:0060039)3.07445572
63regulation of prostaglandin secretion (GO:0032306)3.07364846
64retinal ganglion cell axon guidance (GO:0031290)3.05391693
65inositol phosphate catabolic process (GO:0071545)3.05342064
66establishment of planar polarity (GO:0001736)3.05259935
67establishment of tissue polarity (GO:0007164)3.05259935
68neuron projection extension (GO:1990138)3.04855626
69proline transport (GO:0015824)3.04694597
70protein localization to synapse (GO:0035418)3.02503870
71positive regulation of axon extension (GO:0045773)3.02060136
72cellular response to prostaglandin stimulus (GO:0071379)3.01632440
73negative regulation of osteoblast proliferation (GO:0033689)3.01503407
74membrane depolarization during action potential (GO:0086010)3.00763041
75positive regulation of actin filament depolymerization (GO:0030836)2.99176800
76behavioral response to pain (GO:0048266)2.98680092
77vocalization behavior (GO:0071625)2.98656605
78detection of mechanical stimulus involved in sensory perception (GO:0050974)2.96768931
79semaphorin-plexin signaling pathway (GO:0071526)2.96407060
80positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.94813226
81regulation of cell communication by electrical coupling (GO:0010649)2.92748322
82mesenchymal-epithelial cell signaling (GO:0060638)2.92392008
83protein localization to endosome (GO:0036010)2.92390512
84wound healing, spreading of cells (GO:0044319)2.92171826
85synaptic vesicle maturation (GO:0016188)2.92120214
86regulation of relaxation of muscle (GO:1901077)2.92084619
87negative regulation of membrane potential (GO:0045837)2.88553749
88positive regulation of protein complex disassembly (GO:0043243)2.87925910
89layer formation in cerebral cortex (GO:0021819)2.85902698
90neuron fate specification (GO:0048665)2.85004102
91regulation of platelet aggregation (GO:0090330)2.84710471
92positive regulation of positive chemotaxis (GO:0050927)2.82356260
93regulation of T-helper 1 cell differentiation (GO:0045625)2.81901683
94positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.80410232
95regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.80410232
96renal system development (GO:0072001)2.79867557
97establishment of mitochondrion localization (GO:0051654)2.79422247
98hypotonic response (GO:0006971)2.79301955
99cell junction assembly (GO:0034329)2.79156431
100pyrimidine nucleobase catabolic process (GO:0006208)2.75217408
101planar cell polarity pathway involved in neural tube closure (GO:0090179)2.75180963
102membrane budding (GO:0006900)2.74957009
103negative regulation of protein localization to cell surface (GO:2000009)2.74785227
104regulation of monocyte chemotaxis (GO:0090025)2.74555938
105response to pain (GO:0048265)2.74180844
106regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.73601162
107positive regulation of T-helper cell differentiation (GO:0045624)2.72242459
108negative regulation of stem cell proliferation (GO:2000647)2.71465155
109glutamate secretion (GO:0014047)2.71378443
110response to prostaglandin (GO:0034694)2.70585264
111regulation of homotypic cell-cell adhesion (GO:0034110)2.70505283
112collagen fibril organization (GO:0030199)2.70315969
113sequestering of actin monomers (GO:0042989)2.70304817
114polarized epithelial cell differentiation (GO:0030859)2.70059162
115regulation of positive chemotaxis (GO:0050926)2.69672050
116bundle of His cell to Purkinje myocyte communication (GO:0086069)2.69072805
117regulation of synaptic vesicle transport (GO:1902803)2.68546251
118neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.68249266
119regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.67712330
120sympathetic nervous system development (GO:0048485)2.66412386
121mitochondrion transport along microtubule (GO:0047497)2.65695255
122establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.65695255
123extracellular matrix disassembly (GO:0022617)2.63715353
124collagen metabolic process (GO:0032963)2.63206689
125regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.62121069
126regulation of cell maturation (GO:1903429)2.60856217
127cell junction organization (GO:0034330)2.60838867
128positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.60750972
129negative regulation of cation channel activity (GO:2001258)2.59921823
130membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.59087026
131regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.58523577
132regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.58339455
133regulation of short-term neuronal synaptic plasticity (GO:0048172)2.57938968
134collagen catabolic process (GO:0030574)2.57917930
135proteoglycan biosynthetic process (GO:0030166)2.57660999
136developmental cell growth (GO:0048588)2.57321707
137regulation of glutamate secretion (GO:0014048)2.57069258
138positive regulation of blood vessel endothelial cell migration (GO:0043536)2.56882636
139negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.55637638
140regulation of cAMP-dependent protein kinase activity (GO:2000479)2.55448183
141mammary gland epithelial cell proliferation (GO:0033598)2.54004314
142synaptic vesicle docking involved in exocytosis (GO:0016081)2.53302128
143negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.51136350
144cardiac right ventricle morphogenesis (GO:0003215)2.51112524
145positive regulation of protein depolymerization (GO:1901881)2.50900672
146skin development (GO:0043588)2.50019052
147multicellular organismal macromolecule metabolic process (GO:0044259)2.49994446
148* mammary gland development (GO:0030879)2.49796155
149adherens junction organization (GO:0034332)2.47107834
150smooth muscle tissue development (GO:0048745)2.46753346
151epidermis development (GO:0008544)2.46748361
152regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.46518698
153monocyte chemotaxis (GO:0002548)2.45006051
154actin filament depolymerization (GO:0030042)2.43964958
155negative regulation of anoikis (GO:2000811)2.43886485
156developmental growth involved in morphogenesis (GO:0060560)2.43843324
157intermediate filament-based process (GO:0045103)2.43746689
158gap junction assembly (GO:0016264)2.42999099
159intermediate filament cytoskeleton organization (GO:0045104)2.42239016
160regulation of histone phosphorylation (GO:0033127)2.41528089
161regulation of activation of Janus kinase activity (GO:0010533)2.41158956
162regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.40811756
163axonal fasciculation (GO:0007413)2.40649512
164axon cargo transport (GO:0008088)2.40634957
165apical protein localization (GO:0045176)2.40225519
166limb bud formation (GO:0060174)2.40183214
167metanephric mesenchyme development (GO:0072075)2.40157472
168cerebral cortex radially oriented cell migration (GO:0021799)2.39969130
169adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.39310901
170regulation of axon extension (GO:0030516)2.38685329
171regulation of protein kinase A signaling (GO:0010738)2.38626912
172regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.38141992
173negative regulation of cartilage development (GO:0061037)2.38022437
174multicellular organismal metabolic process (GO:0044236)2.37721380
175atrioventricular valve morphogenesis (GO:0003181)2.37533824
176protein localization to microtubule (GO:0035372)2.36796095
177renal filtration (GO:0097205)2.35832899
178* wound healing (GO:0042060)2.35424872
179regulation of fever generation (GO:0031620)2.33829356
180neuron recognition (GO:0008038)2.33614111
181* neural crest cell development (GO:0014032)2.33064240
182regulation of hippo signaling (GO:0035330)2.32866396
183plasma membrane repair (GO:0001778)2.32393592
184membrane assembly (GO:0071709)2.31855058
185positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.31111858
186positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.30510631
187ribonucleoprotein complex disassembly (GO:0032988)2.29902626
188regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.29685175
189regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.27989490
190establishment or maintenance of monopolar cell polarity (GO:0061339)2.27306536
191establishment of monopolar cell polarity (GO:0061162)2.27306536
192hemidesmosome assembly (GO:0031581)13.1959976

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.20565013
2* GBX2_23144817_ChIP-Seq_PC3_Human3.15238230
3IGF1R_20145208_ChIP-Seq_DFB_Human3.11092017
4EZH2_22144423_ChIP-Seq_EOC_Human3.02098375
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.70753861
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.69798779
7BMI1_23680149_ChIP-Seq_NPCS_Mouse2.51155850
8TAF15_26573619_Chip-Seq_HEK293_Human2.46356780
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.45009763
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.43246399
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.42251318
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.35545007
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.34977346
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.30788551
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.30788551
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29853156
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.17864963
18SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.16557457
19SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.16557457
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15466514
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.08485255
22TP53_16413492_ChIP-PET_HCT116_Human2.06864663
23* BRD4_25478319_ChIP-Seq_HGPS_Human2.02457018
24STAT6_21828071_ChIP-Seq_BEAS2B_Human2.02217916
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00475319
26TP63_17297297_ChIP-ChIP_HaCaT_Human10.2830033
27* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99372669
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.99291114
29* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.97234861
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.97123851
31* SMAD4_21799915_ChIP-Seq_A2780_Human1.95663593
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93830376
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92379893
34* P300_19829295_ChIP-Seq_ESCs_Human1.92324291
35* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91330900
36* RNF2_27304074_Chip-Seq_ESCs_Mouse1.88339130
37NR3C1_23031785_ChIP-Seq_PC12_Mouse1.88103679
38* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87323111
39* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.81815381
40TP53_18474530_ChIP-ChIP_U2OS_Human1.78263806
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.76838669
42AHR_22903824_ChIP-Seq_MCF-7_Human1.74604772
43VDR_22108803_ChIP-Seq_LS180_Human1.74000735
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.72491623
45SOX9_24532713_ChIP-Seq_HFSC_Mouse1.71707942
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.68374497
47HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.65581174
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.64023817
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.61956228
50NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.61956228
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.60724255
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59036861
53AR_25329375_ChIP-Seq_VCAP_Human1.56428700
54JUN_21703547_ChIP-Seq_K562_Human1.55680393
55EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.54333252
56* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53194928
57* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52139370
58* REST_21632747_ChIP-Seq_MESCs_Mouse1.52134080
59TP63_23658742_ChIP-Seq_EP156T_Human1.50617626
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50391426
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45960860
62* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.45788984
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.45445183
64* RNF2_27304074_Chip-Seq_NSC_Mouse1.45145958
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.44750604
66BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44442206
67* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43914760
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.43480144
69AR_21572438_ChIP-Seq_LNCaP_Human1.41484469
70ER_23166858_ChIP-Seq_MCF-7_Human1.40080030
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38966800
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38776155
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37726455
74* CJUN_26792858_Chip-Seq_BT549_Human1.37435330
75SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.36724811
76* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32600376
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32134212
78* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26154410
79* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25504863
80RARG_19884340_ChIP-ChIP_MEFs_Mouse1.25305173
81TCF4_18268006_ChIP-ChIP_LS174T_Human1.24765977
82* WT1_19549856_ChIP-ChIP_CCG9911_Human1.24609011
83* UBF1/2_26484160_Chip-Seq_HMECs_Human1.24123089
84NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.22971021
85* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22511108
86PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21785143
87FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.21085851
88* STAT3_23295773_ChIP-Seq_U87_Human1.20558952
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20383175
90* SMAD3_21741376_ChIP-Seq_EPCs_Human1.20314966
91P63_26484246_Chip-Seq_KERATINOCYTES_Human1.19984576
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17602240
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17601271
94BCAT_22108803_ChIP-Seq_LS180_Human1.17134071
95RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16469319
96* PRDM14_20953172_ChIP-Seq_ESCs_Human1.16229343
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.16039476
98BP1_19119308_ChIP-ChIP_Hs578T_Human1.15899918
99SMAD3_21741376_ChIP-Seq_HESCs_Human1.14277421
100VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14233878
101CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13820539
102GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13797969
103RUNX2_22187159_ChIP-Seq_PCA_Human1.13334509
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13060195
105REST_18959480_ChIP-ChIP_MESCs_Mouse1.12899383
106E2F1_18555785_Chip-Seq_ESCs_Mouse1.12174509
107ELK4_26923725_Chip-Seq_MESODERM_Mouse1.11706275
108SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11625146
109GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09953739
110NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09380509
111TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08900784
112TP53_20018659_ChIP-ChIP_R1E_Mouse1.08888814
113EP300_21415370_ChIP-Seq_HL-1_Mouse1.08882750
114* SOX2_21211035_ChIP-Seq_LN229_Gbm1.08730974
115GATA2_21666600_ChIP-Seq_HMVEC_Human1.08262024
116ISL1_27105846_Chip-Seq_CPCs_Mouse1.07144576
117P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05634289
118KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04979193
119* KDM2B_26808549_Chip-Seq_REH_Human1.04304017
120FOXO3_23340844_ChIP-Seq_DLD1_Human1.04277471
121P53_22387025_ChIP-Seq_ESCs_Mouse1.03912534
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03786794
123* TP53_22127205_ChIP-Seq_IMR90_Human1.03467765
124STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03049423
125VDR_24787735_ChIP-Seq_THP-1_Human1.02357336
126TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00843966
127CMYC_18555785_Chip-Seq_ESCs_Mouse1.00125647
128* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99601155
129FLI1_27457419_Chip-Seq_LIVER_Mouse0.99282927
130* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98408334
131* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97793291
132SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97601395
133RXR_22108803_ChIP-Seq_LS180_Human0.97556999
134TCF4_22108803_ChIP-Seq_LS180_Human0.97422736
135* TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96655455
136TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96627958
137ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96340274
138RING1B_27294783_Chip-Seq_NPCs_Mouse0.96012363
139* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95837676
140WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95358202
141Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95155716
142TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94827916
143SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.94628988
144TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93849377
145* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93397017
146SMAD3_21741376_ChIP-Seq_ESCs_Human0.93009208
147SMAD4_21741376_ChIP-Seq_EPCs_Human0.91944872
148RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91779337
149MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90957742
150HIF1A_21447827_ChIP-Seq_MCF-7_Human0.89599384
151ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.89431292

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception6.14395002
2MP0000579_abnormal_nail_morphology5.83590328
3MP0004858_abnormal_nervous_system4.43966763
4MP0006276_abnormal_autonomic_nervous4.43921870
5MP0001348_abnormal_lacrimal_gland4.25123223
6MP0001968_abnormal_touch/_nociception3.72400725
7MP0003705_abnormal_hypodermis_morpholog3.70406578
8MP0001986_abnormal_taste_sensitivity3.64992813
9MP0004272_abnormal_basement_membrane3.59602563
10MP0002736_abnormal_nociception_after3.41660553
11MP0005275_abnormal_skin_tensile3.14893419
12* MP0002734_abnormal_mechanical_nocicepti3.03153344
13* MP0004270_analgesia3.01656699
14MP0000762_abnormal_tongue_morphology3.00182324
15MP0009053_abnormal_anal_canal2.82343501
16MP0002733_abnormal_thermal_nociception2.78795515
17MP0005257_abnormal_intraocular_pressure2.75653320
18MP0001970_abnormal_pain_threshold2.50575575
19MP0005623_abnormal_meninges_morphology2.44389950
20MP0003941_abnormal_skin_development2.37444714
21MP0004859_abnormal_synaptic_plasticity2.36039327
22MP0003880_abnormal_central_pattern2.35750499
23* MP0002184_abnormal_innervation2.34337168
24MP0010368_abnormal_lymphatic_system2.33849121
25MP0000467_abnormal_esophagus_morphology2.29112625
26MP0002876_abnormal_thyroid_physiology2.23597862
27MP0009046_muscle_twitch2.21135004
28MP0002060_abnormal_skin_morphology2.20546252
29MP0002234_abnormal_pharynx_morphology2.14403259
30MP0000537_abnormal_urethra_morphology2.08491048
31MP0009780_abnormal_chondrocyte_physiolo2.04128282
32MP0005645_abnormal_hypothalamus_physiol2.03395774
33MP0005409_darkened_coat_color2.00042642
34MP0005023_abnormal_wound_healing1.99768515
35MP0009384_cardiac_valve_regurgitation1.98119621
36MP0001346_abnormal_lacrimal_gland1.95259705
37MP0001958_emphysema1.83767366
38* MP0003635_abnormal_synaptic_transmissio1.79721703
39MP0000778_abnormal_nervous_system1.79012976
40MP0002063_abnormal_learning/memory/cond1.78111066
41MP0002067_abnormal_sensory_capabilities1.72452358
42MP0003755_abnormal_palate_morphology1.68948215
43* MP0002751_abnormal_autonomic_nervous1.66350718
44MP0010030_abnormal_orbit_morphology1.65369667
45MP0000383_abnormal_hair_follicle1.64054132
46MP0001299_abnormal_eye_distance/1.61208564
47* MP0002272_abnormal_nervous_system1.59453149
48MP0004811_abnormal_neuron_physiology1.57397465
49MP0001216_abnormal_epidermal_layer1.56255686
50MP0000566_synostosis1.53892455
51MP0003279_aneurysm1.51779316
52MP0002254_reproductive_system_inflammat1.50487010
53MP0001984_abnormal_olfaction1.49005350
54MP0003950_abnormal_plasma_membrane1.46022602
55MP0002896_abnormal_bone_mineralization1.45943970
56MP0002572_abnormal_emotion/affect_behav1.42545507
57MP0010678_abnormal_skin_adnexa1.41870983
58MP0009745_abnormal_behavioral_response1.40455446
59MP0001188_hyperpigmentation1.40302520
60MP0002148_abnormal_hypersensitivity_rea1.39395882
61MP0000372_irregular_coat_pigmentation1.38429072
62MP0002098_abnormal_vibrissa_morphology1.38304026
63MP0004142_abnormal_muscle_tone1.37919913
64MP0001440_abnormal_grooming_behavior1.36358872
65MP0002064_seizures1.35816382
66MP0002138_abnormal_hepatobiliary_system1.35310546
67MP0003315_abnormal_perineum_morphology1.30717359
68MP0002163_abnormal_gland_morphology1.29739491
69MP0001835_abnormal_antigen_presentation1.28420672
70MP0004883_abnormal_blood_vessel1.28139983
71MP0002160_abnormal_reproductive_system1.27513877
72MP0000427_abnormal_hair_cycle1.25335977
73MP0010771_integument_phenotype1.24650203
74MP0001486_abnormal_startle_reflex1.23843488
75* MP0000955_abnormal_spinal_cord1.20808738
76MP0003879_abnormal_hair_cell1.20408492
77MP0008789_abnormal_olfactory_epithelium1.19685086
78MP0002177_abnormal_outer_ear1.18102183
79MP0003091_abnormal_cell_migration1.16416764
80MP0001542_abnormal_bone_strength1.16250158
81MP0004510_myositis1.15922235
82MP0000428_abnormal_craniofacial_morphol1.15579198
83* MP0002882_abnormal_neuron_morphology1.12424650
84MP0000767_abnormal_smooth_muscle1.12108054
85MP0001879_abnormal_lymphatic_vessel1.11911752
86MP0002233_abnormal_nose_morphology1.09323313
87MP0003935_abnormal_craniofacial_develop1.08812615
88MP0005595_abnormal_vascular_smooth1.07571256
89MP0003453_abnormal_keratinocyte_physiol1.06219194
90MP0002796_impaired_skin_barrier1.06005356
91MP0005248_abnormal_Harderian_gland1.05381558
92MP0000569_abnormal_digit_pigmentation1.05006137
93MP0000534_abnormal_ureter_morphology1.04717941
94MP0004742_abnormal_vestibular_system1.03191634
95MP0006054_spinal_hemorrhage1.02044863
96MP0010386_abnormal_urinary_bladder1.01285372
97MP0003937_abnormal_limbs/digits/tail_de1.01203297
98MP0005501_abnormal_skin_physiology1.01164173
99MP0000432_abnormal_head_morphology1.01077292
100MP0009697_abnormal_copulation1.00836424
101MP0005423_abnormal_somatic_nervous1.00774118
102MP0002295_abnormal_pulmonary_circulatio0.98979187
103MP0004924_abnormal_behavior0.96325470
104MP0005386_behavior/neurological_phenoty0.96325470
105MP0002168_other_aberrant_phenotype0.94594409
106MP0000538_abnormal_urinary_bladder0.94460150
107MP0002557_abnormal_social/conspecific_i0.94243088
108MP0005187_abnormal_penis_morphology0.94050809
109MP0005508_abnormal_skeleton_morphology0.91576993
110MP0004133_heterotaxia0.91308892
111MP0002697_abnormal_eye_size0.90410474
112* MP0002752_abnormal_somatic_nervous0.89074525
113MP0000733_abnormal_muscle_development0.88744651
114MP0005360_urolithiasis0.88147081
115MP0000377_abnormal_hair_follicle0.86722641
116MP0005193_abnormal_anterior_eye0.86502123
117MP0001501_abnormal_sleep_pattern0.85885244
118MP0005310_abnormal_salivary_gland0.84473132
119MP0010352_gastrointestinal_tract_polyps0.83596602
120MP0001485_abnormal_pinna_reflex0.83389172
121MP0000647_abnormal_sebaceous_gland0.82743111
122MP0005503_abnormal_tendon_morphology0.81976252
123* MP0002066_abnormal_motor_capabilities/c0.80125018
124MP0005394_taste/olfaction_phenotype0.79720196
125MP0005499_abnormal_olfactory_system0.79720196
126* MP0000627_abnormal_mammary_gland0.77969973
127MP0010234_abnormal_vibrissa_follicle0.77251495
128MP0000678_abnormal_parathyroid_gland0.76738887
129MP0003329_amyloid_beta_deposits0.76640837
130MP0001529_abnormal_vocalization0.75176077
131MP0003942_abnormal_urinary_system0.74153388
132MP0001963_abnormal_hearing_physiology0.73201584
133MP0001502_abnormal_circadian_rhythm0.72806379
134MP0009250_abnormal_appendicular_skeleto0.71558375
135MP0001340_abnormal_eyelid_morphology0.70352899
136MP0002089_abnormal_postnatal_growth/wei0.70284675
137MP0001243_abnormal_dermal_layer0.70078817
138MP0003385_abnormal_body_wall0.69048773
139MP0009785_altered_susceptibility_to0.68889190
140MP0005000_abnormal_immune_tolerance0.68731730
141MP0000163_abnormal_cartilage_morphology0.68426621
142MP0002116_abnormal_craniofacial_bone0.68255844
143MP0005164_abnormal_response_to0.67971935
144MP0008260_abnormal_autophagy0.67594331
145MP0000462_abnormal_digestive_system0.66921009
146MP0008874_decreased_physiological_sensi0.66907510
147MP0000751_myopathy0.65840551
148MP0003890_abnormal_embryonic-extraembry0.65830511
149MP0002109_abnormal_limb_morphology0.65360640
150MP0004134_abnormal_chest_morphology0.65319161
151MP0006138_congestive_heart_failure0.65076695
152MP0003045_fibrosis0.64633725
153MP0000049_abnormal_middle_ear0.64469595
154MP0000013_abnormal_adipose_tissue0.64366838
155MP0008569_lethality_at_weaning0.64324073
156MP0000685_abnormal_immune_system0.63407640
157MP0003566_abnormal_cell_adhesion0.63118522
158MP0009764_decreased_sensitivity_to0.62688939
159MP0003122_maternal_imprinting0.60982639
160MP0005197_abnormal_uvea_morphology0.60814468
161MP0008438_abnormal_cutaneous_collagen0.59689863
162* MP0003634_abnormal_glial_cell0.57868305
163MP0005389_reproductive_system_phenotype0.57765651
164MP0006082_CNS_inflammation0.56643802
165MP0003436_decreased_susceptibility_to0.56499143
166MP0001849_ear_inflammation0.56425828
167MP0000026_abnormal_inner_ear0.56311163
168MP0002282_abnormal_trachea_morphology0.56299221
169MP0003631_nervous_system_phenotype0.56288850
170MP0001905_abnormal_dopamine_level0.54140658
171MP0000604_amyloidosis0.51292056
172MP0005084_abnormal_gallbladder_morpholo0.50630535

Predicted human phenotypes

RankGene SetZ-score
1Atrophic scars (HP:0001075)8.04171533
2Milia (HP:0001056)7.29297838
3Fragile nails (HP:0001808)6.65215993
4Myokymia (HP:0002411)6.39696200
5Ulnar claw (HP:0001178)6.08277910
6Onycholysis (HP:0001806)5.48602636
7Febrile seizures (HP:0002373)4.69486273
8Plantar hyperkeratosis (HP:0007556)4.58398889
9Hypothermia (HP:0002045)4.29551103
10Thick nail (HP:0001805)4.19822194
11Premature rupture of membranes (HP:0001788)4.19083582
12Action tremor (HP:0002345)4.19018789
13Abnormality of nail color (HP:0100643)3.70461106
14Nail dystrophy (HP:0008404)3.69933700
15Atonic seizures (HP:0010819)3.66339214
16Segmental peripheral demyelination/remyelination (HP:0003481)3.62044412
17Follicular hyperkeratosis (HP:0007502)3.60085713
18Retrobulbar optic neuritis (HP:0100654)3.59474468
19Optic neuritis (HP:0100653)3.59474468
20Pheochromocytoma (HP:0002666)3.57961093
21Neuroendocrine neoplasm (HP:0100634)3.57953868
22Failure to thrive in infancy (HP:0001531)3.36888990
23Natal tooth (HP:0000695)3.35117313
24Arterial tortuosity (HP:0005116)3.31274952
25Protrusio acetabuli (HP:0003179)3.29835402
26Pterygium (HP:0001059)3.27518245
27Progressive cerebellar ataxia (HP:0002073)3.27474610
28Alopecia of scalp (HP:0002293)3.25644713
29Focal seizures (HP:0007359)3.24802704
30Focal motor seizures (HP:0011153)3.23220307
31Orchitis (HP:0100796)3.20733381
32Vascular tortuosity (HP:0004948)3.18265104
33Hypoplasia of dental enamel (HP:0006297)3.11498622
34Impaired pain sensation (HP:0007328)2.96817857
35Abnormality of pain sensation (HP:0010832)2.96817857
36Termporal pattern (HP:0011008)2.96390514
37Insidious onset (HP:0003587)2.96390514
38Abnormal hair whorl (HP:0010721)2.94260383
39Vertebral compression fractures (HP:0002953)2.93906375
40Ankle contracture (HP:0006466)2.93382454
41Aplasia cutis congenita (HP:0001057)2.91210315
42Bradycardia (HP:0001662)2.83371613
43Ridged nail (HP:0001807)2.80407433
44Wrist flexion contracture (HP:0001239)2.79531415
45Aortic dissection (HP:0002647)2.72349350
46Shallow orbits (HP:0000586)2.70515413
47Hypoventilation (HP:0002791)2.69694114
48Hypercortisolism (HP:0001578)2.68756121
49Cervical subluxation (HP:0003308)2.68037414
50Epileptic encephalopathy (HP:0200134)2.66676362
51Palmoplantar hyperkeratosis (HP:0000972)2.66216978
52Selective tooth agenesis (HP:0001592)2.63397073
53Eczematoid dermatitis (HP:0000976)2.57530891
54Palmar hyperkeratosis (HP:0010765)2.55488903
55Genu recurvatum (HP:0002816)2.52952339
56Esophageal atresia (HP:0002032)2.45440933
57Curly hair (HP:0002212)2.45425857
58Abnormal blistering of the skin (HP:0008066)2.42609115
59Supranuclear gaze palsy (HP:0000605)2.42092787
60Hammertoe (HP:0001765)2.39510561
61Amblyopia (HP:0000646)2.38270508
62Foot dorsiflexor weakness (HP:0009027)2.37612196
63Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.36402410
64Absence seizures (HP:0002121)2.36198585
65Ankyloglossia (HP:0010296)2.34143338
66Gait imbalance (HP:0002141)2.32828810
67Neonatal short-limb short stature (HP:0008921)2.30630506
68Limb dystonia (HP:0002451)2.29856072
69Asymmetry of the thorax (HP:0001555)2.29717527
70Myositis (HP:0100614)2.29274912
71Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.28365095
72Thyroid carcinoma (HP:0002890)2.26666943
73Autoamputation (HP:0001218)2.26520997
74Broad face (HP:0000283)2.26355219
75Fetal akinesia sequence (HP:0001989)2.25052748
76Bronchomalacia (HP:0002780)2.24401346
77Tibial bowing (HP:0002982)2.24319404
78Bladder diverticulum (HP:0000015)2.23007420
79Spinal rigidity (HP:0003306)2.22610700
80Xerostomia (HP:0000217)2.22296119
81Narrow nasal bridge (HP:0000446)2.22157626
82Abnormality of the vocal cords (HP:0008777)2.21876590
83Wormian bones (HP:0002645)2.20298566
84Submucous cleft hard palate (HP:0000176)2.20021802
85Steppage gait (HP:0003376)2.19832535
86Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.18938735
87Decreased motor nerve conduction velocity (HP:0003431)2.18069575
88Ulnar bowing (HP:0003031)2.17599414
89Abnormality of oral frenula (HP:0000190)2.16648462
90Neoplasm of the peripheral nervous system (HP:0100007)2.12095829
91Broad metatarsal (HP:0001783)2.11901511
92Exotropia (HP:0000577)2.11460897
93Abnormality of the nasal septum (HP:0000419)2.10585582
94Abnormality of dentin (HP:0010299)2.10414220
95Vertebral arch anomaly (HP:0008438)2.10271086
96Medial flaring of the eyebrow (HP:0010747)2.10230020
97Overgrowth (HP:0001548)2.09835612
98Laryngomalacia (HP:0001601)2.08313124
99Keratoconjunctivitis (HP:0001096)2.07781372
100Lower limb muscle weakness (HP:0007340)2.06902268
101Myotonia (HP:0002486)2.05968542
102Peritonitis (HP:0002586)2.05106670
103Advanced eruption of teeth (HP:0006288)2.04468512
104Congenital primary aphakia (HP:0007707)2.03674914
105Recurrent abscess formation (HP:0002722)2.03229649
106Generalized tonic-clonic seizures (HP:0002069)2.01731439
107Hypodontia (HP:0000668)2.00935228
108Aortic aneurysm (HP:0004942)2.00699481
109Abnormality of the foot musculature (HP:0001436)2.00535017
110Short nail (HP:0001799)2.00526079
111Genital tract atresia (HP:0001827)1.96227998
112Fragile skin (HP:0001030)1.94123105
113Dialeptic seizures (HP:0011146)1.93696258
114Distal sensory impairment (HP:0002936)1.92651969
115Anonychia (HP:0001798)1.92049375
116Recurrent bacterial skin infections (HP:0005406)1.90473499
117Akinesia (HP:0002304)1.90066011
118Lower limb amyotrophy (HP:0007210)1.89804086
119Pili torti (HP:0003777)1.89709285
120Heterochromia iridis (HP:0001100)1.88945960
121Polyphagia (HP:0002591)1.88109804
122Nephrogenic diabetes insipidus (HP:0009806)1.87851284
123Metaphyseal dysplasia (HP:0100255)1.87394018
124Hydroureter (HP:0000072)1.87373504
125Soft skin (HP:0000977)1.86349897
126Sparse scalp hair (HP:0002209)1.86340183
127Thoracolumbar scoliosis (HP:0002944)1.85781912
128Aplasia/Hypoplasia of the brainstem (HP:0007362)1.84641680
129Hypoplasia of the brainstem (HP:0002365)1.84641680
130Ureteral stenosis (HP:0000071)1.84507930
131Fibular aplasia (HP:0002990)1.83954782
132Nuclear cataract (HP:0100018)1.83940799
133Vaginal atresia (HP:0000148)1.83400622
134Mitral valve prolapse (HP:0001634)1.83273319
135Muscle fibrillation (HP:0010546)1.81755644
136Hypoplastic labia majora (HP:0000059)1.79345121
137Fatigable weakness (HP:0003473)1.79019323
138Abnormality of the neuromuscular junction (HP:0003398)1.79019323
139Dysautonomia (HP:0002459)1.78194754
140Aplasia/Hypoplasia of the clavicles (HP:0006710)1.77948337
141Bowing of the arm (HP:0006488)1.77721748
142Bowed forearm bones (HP:0003956)1.77721748
143Spinal canal stenosis (HP:0003416)1.77285531
144Aqueductal stenosis (HP:0002410)1.76981581
145Coronal craniosynostosis (HP:0004440)1.76757691
146Slender build (HP:0001533)1.76587079
147Specific learning disability (HP:0001328)1.76361105
148Delayed gross motor development (HP:0002194)1.76337455
149Tongue fasciculations (HP:0001308)1.75906546
150Wide anterior fontanel (HP:0000260)1.75409528
151Right ventricular cardiomyopathy (HP:0011663)1.75193632
152Tetraparesis (HP:0002273)1.73702183
153Oligodontia (HP:0000677)1.72516657
154Ureteral obstruction (HP:0006000)1.72028159
155Camptodactyly of toe (HP:0001836)1.71845719
156Impaired vibration sensation in the lower limbs (HP:0002166)1.71489248
157Menstrual irregularities (HP:0000858)1.71387421
158Progressive sensorineural hearing impairment (HP:0000408)1.68774884
159Abnormal eating behavior (HP:0100738)1.68293792
160Absent phalangeal crease (HP:0006109)1.67918200
161Radial bowing (HP:0002986)1.67543001
162Microglossia (HP:0000171)1.67385061
163Aplasia/Hypoplasia of the lens (HP:0008063)1.67214536
164Onion bulb formation (HP:0003383)1.67179870
165Short clavicles (HP:0000894)1.65493867
166Abnormal ossification of hand bones (HP:0005921)1.65036983
167Achilles tendon contracture (HP:0001771)1.64984513
168Parakeratosis (HP:0001036)1.63943853
169Apathy (HP:0000741)1.63857390
170Pulmonic stenosis (HP:0001642)1.63594448
171Abnormality of carpal bone ossification (HP:0006257)1.63524630
172Distal lower limb muscle weakness (HP:0009053)1.63452805
173Mitral regurgitation (HP:0001653)1.61665106
174Cardiovascular calcification (HP:0011915)1.59367104
175Osteolytic defects of the hand bones (HP:0009699)1.59270442
176Osteolytic defects of the phalanges of the hand (HP:0009771)1.59270442
177Hypoplastic nipples (HP:0002557)1.58748167
178Abnormality of the antihelix (HP:0009738)1.58681639
179Obstructive sleep apnea (HP:0002870)1.58180535
180Abnormality of the labia majora (HP:0012881)1.57582690
181Absent frontal sinuses (HP:0002688)1.57140636
182Abnormal hair laboratory examination (HP:0003328)1.56638641
183Woolly hair (HP:0002224)1.56489347
184Hoarse voice (HP:0001609)1.55725317
185Hypoplastic toenails (HP:0001800)1.54686210
186Abnormality of the distal phalanx of the thumb (HP:0009617)1.54423155
187Recurrent corneal erosions (HP:0000495)1.54388521
188Elbow flexion contracture (HP:0002987)1.54141424
189Carious teeth (HP:0000670)1.54079488
190Corneal erosion (HP:0200020)1.53733837
191Joint laxity (HP:0001388)1.51526357
192Blue sclerae (HP:0000592)1.51472947
193Aortic regurgitation (HP:0001659)1.50097021
194Mildly elevated creatine phosphokinase (HP:0008180)1.48385443
195Gastrointestinal atresia (HP:0002589)1.46412215

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.26776630
2SIK33.93322669
3TAOK23.49660950
4MINK13.30675246
5MET3.25325978
6NTRK33.23185457
7MAP3K123.10563869
8MST1R2.81903977
9PTK22.79265868
10MAP3K142.70189171
11BMPR22.68414098
12PDGFRA2.66522036
13TTN2.61991734
14BCR2.42462485
15LIMK12.32651535
16SIK12.31078077
17PIM22.29175062
18ARAF2.15200335
19EPHA22.14503526
20MAPK132.06417672
21NTRK12.04292214
22EPHA32.03233813
23ERBB31.98031561
24PNCK1.97920778
25MARK11.95855791
26MAP2K71.81682844
27RIPK11.81138909
28LATS21.76741966
29LATS11.71821019
30SGK21.70931303
31NEK91.64235646
32CAMK1G1.61367131
33PLK21.58593285
34LMTK21.56986754
35MAP3K41.55930983
36DYRK21.54172496
37FLT31.50675786
38KSR11.44097585
39BMPR1B1.41913523
40STK241.40029060
41SGK2231.38108342
42SGK4941.38108342
43RIPK41.35089414
44TGFBR21.34876880
45MAP4K21.34521625
46RPS6KA21.34112829
47GRK51.32330816
48AKT31.31763430
49PAK21.30724940
50MAP3K91.29230066
51MYLK1.26896124
52TGFBR11.23546629
53PAK41.14797179
54PDGFRB1.12984271
55MAP2K41.12981775
56MST41.08903506
57FER1.03749072
58MATK1.03270524
59SIK21.02943087
60PRKD21.02844509
61MAP2K11.00574136
62KSR20.99165041
63TESK10.98368360
64PAK60.95657087
65BRAF0.95512825
66ADRBK10.95371300
67MAP3K80.93596201
68YES10.93555114
69SGK30.91371038
70MAPKAPK30.88277825
71STK380.87447216
72MAP2K60.86215190
73PAK30.81797718
74ABL20.80672667
75PRKCE0.80410987
76MELK0.79634817
77STK38L0.79496137
78CAMK1D0.77980136
79CHUK0.76752599
80CDK50.75246706
81RET0.74357752
82IKBKB0.72970232
83WNK10.72774636
84ICK0.72476951
85PTK2B0.71546784
86MOS0.71287431
87PRKCG0.68140331
88ERBB40.66495266
89MTOR0.63486742
90CDK140.62597662
91TRPM70.59922947
92EPHB20.57884672
93CDK180.57793396
94CAMKK20.56494907
95DAPK20.56127466
96FGFR30.55156551
97IRAK30.54557427
98ROCK10.54432350
99MAP3K20.54042455
100CSNK1A1L0.53634945
101GRK70.52555468
102MAP3K110.51939760
103MAP3K50.51928991
104ADRBK20.50745279
105GSK3A0.49853222
106ERN10.49625283
107DDR20.49498594
108RPS6KB10.49020191
109PHKG20.48320828
110PHKG10.48320828
111ERBB20.47881486
112ROCK20.45907764
113BMX0.45502059
114BLK0.45344345
115WNK40.45082874
116MAP3K60.44597775
117PRKD30.43576092
118CAMK2A0.42193244
119CAMKK10.41006340
120CDK120.40051758
121PRPF4B0.39359796
122GRK10.37497942
123PRKCZ0.37036578
124PIM10.36140771
125RPS6KA60.36101757
126PIK3CA0.35582832
127FRK0.35212797
128CAMK2G0.34954966
129CDK150.34626125
130INSR0.34355358
131CDK80.34209698
132TRIB30.34051545
133CDC42BPA0.33125084
134PRKCD0.32365177
135IRAK10.32226670
136AURKA0.31555651
137NTRK20.30714600
138IGF1R0.30240173
139RPS6KC10.29913967
140RPS6KL10.29913967
141CAMK2B0.29700148
142MARK20.29543453
143EPHB10.29063129
144TAOK10.28626660
145MAP3K10.28320487
146TBK10.27923454
147SCYL20.27851370
148PIK3CG0.26749958
149RAF10.26640208
150MAPK80.26493424
151SRC0.21513149

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.94239886
2Synaptic vesicle cycle_Homo sapiens_hsa047213.02321399
3Focal adhesion_Homo sapiens_hsa045102.72430840
4Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.28341062
5Small cell lung cancer_Homo sapiens_hsa052222.24991857
6Olfactory transduction_Homo sapiens_hsa047402.16298230
7Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.15992833
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.04105192
9Adherens junction_Homo sapiens_hsa045201.97019274
10Collecting duct acid secretion_Homo sapiens_hsa049661.93832395
11Proteoglycans in cancer_Homo sapiens_hsa052051.86905980
12Rheumatoid arthritis_Homo sapiens_hsa053231.86511765
13Phagosome_Homo sapiens_hsa041451.84001673
14Dilated cardiomyopathy_Homo sapiens_hsa054141.83093298
15Graft-versus-host disease_Homo sapiens_hsa053321.78959884
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.77746248
17Salmonella infection_Homo sapiens_hsa051321.73246234
18Hippo signaling pathway_Homo sapiens_hsa043901.65811073
19Bladder cancer_Homo sapiens_hsa052191.59490290
20Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.58433668
21Nicotine addiction_Homo sapiens_hsa050331.50885482
22MicroRNAs in cancer_Homo sapiens_hsa052061.50783664
23Type I diabetes mellitus_Homo sapiens_hsa049401.49876817
24Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.48977822
25TGF-beta signaling pathway_Homo sapiens_hsa043501.48203814
26Vibrio cholerae infection_Homo sapiens_hsa051101.43709664
27Taste transduction_Homo sapiens_hsa047421.43518978
28Cholinergic synapse_Homo sapiens_hsa047251.41305060
29Dopaminergic synapse_Homo sapiens_hsa047281.40379233
30Melanoma_Homo sapiens_hsa052181.40213911
31Neurotrophin signaling pathway_Homo sapiens_hsa047221.40207351
32Oxidative phosphorylation_Homo sapiens_hsa001901.34969101
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34042131
34Serotonergic synapse_Homo sapiens_hsa047261.33984130
35Basal cell carcinoma_Homo sapiens_hsa052171.30822414
36Hedgehog signaling pathway_Homo sapiens_hsa043401.29832366
37Allograft rejection_Homo sapiens_hsa053301.26582213
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25225064
39Leishmaniasis_Homo sapiens_hsa051401.25110400
40Tuberculosis_Homo sapiens_hsa051521.24312896
41Pathways in cancer_Homo sapiens_hsa052001.23959520
42Circadian entrainment_Homo sapiens_hsa047131.21902884
43Protein digestion and absorption_Homo sapiens_hsa049741.21622147
44Axon guidance_Homo sapiens_hsa043601.21209244
45Chronic myeloid leukemia_Homo sapiens_hsa052201.16678257
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.15961362
47Long-term potentiation_Homo sapiens_hsa047201.14775366
48p53 signaling pathway_Homo sapiens_hsa041151.12028633
49Pertussis_Homo sapiens_hsa051331.11397465
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09369008
51Shigellosis_Homo sapiens_hsa051311.08042017
52Glutamatergic synapse_Homo sapiens_hsa047241.06595510
53Parkinsons disease_Homo sapiens_hsa050121.05761917
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.05379562
55Renal cell carcinoma_Homo sapiens_hsa052111.04741125
56Prolactin signaling pathway_Homo sapiens_hsa049171.04332809
57TNF signaling pathway_Homo sapiens_hsa046681.04110299
58Morphine addiction_Homo sapiens_hsa050321.01138733
59Glioma_Homo sapiens_hsa052141.01021486
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.00972518
61Estrogen signaling pathway_Homo sapiens_hsa049151.00969516
62Alzheimers disease_Homo sapiens_hsa050101.00312250
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99183042
64Steroid biosynthesis_Homo sapiens_hsa001000.97189312
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96918315
66GnRH signaling pathway_Homo sapiens_hsa049120.96251170
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95301930
68Proteasome_Homo sapiens_hsa030500.94573571
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94288043
70Chemokine signaling pathway_Homo sapiens_hsa040620.93431540
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93324222
72GABAergic synapse_Homo sapiens_hsa047270.91929830
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91575243
74MAPK signaling pathway_Homo sapiens_hsa040100.91018531
75Endometrial cancer_Homo sapiens_hsa052130.90091838
76Amoebiasis_Homo sapiens_hsa051460.89333495
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87658819
78Amphetamine addiction_Homo sapiens_hsa050310.86656506
79Dorso-ventral axis formation_Homo sapiens_hsa043200.86345771
80Cocaine addiction_Homo sapiens_hsa050300.85909313
81African trypanosomiasis_Homo sapiens_hsa051430.85672111
82Legionellosis_Homo sapiens_hsa051340.85338989
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84720156
84Asthma_Homo sapiens_hsa053100.84511984
85Notch signaling pathway_Homo sapiens_hsa043300.84259004
86Thyroid cancer_Homo sapiens_hsa052160.83387765
87Wnt signaling pathway_Homo sapiens_hsa043100.82946717
88* ErbB signaling pathway_Homo sapiens_hsa040120.81107069
89Gap junction_Homo sapiens_hsa045400.80781568
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80641095
91Tight junction_Homo sapiens_hsa045300.80338390
92Viral myocarditis_Homo sapiens_hsa054160.80228149
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79370584
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.79161518
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78386027
96Insulin secretion_Homo sapiens_hsa049110.77672486
97Toxoplasmosis_Homo sapiens_hsa051450.76512431
98Ras signaling pathway_Homo sapiens_hsa040140.76321002
99Huntingtons disease_Homo sapiens_hsa050160.75434792
100Prostate cancer_Homo sapiens_hsa052150.75402040
101Gastric acid secretion_Homo sapiens_hsa049710.74930869
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.72238639
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71656068
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70253354
105Phototransduction_Homo sapiens_hsa047440.69036585
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69016002
107Oxytocin signaling pathway_Homo sapiens_hsa049210.67520072
108VEGF signaling pathway_Homo sapiens_hsa043700.66825564
109Cardiac muscle contraction_Homo sapiens_hsa042600.65803105
110Apoptosis_Homo sapiens_hsa042100.65134862
111Rap1 signaling pathway_Homo sapiens_hsa040150.65127233
112Prion diseases_Homo sapiens_hsa050200.64818701
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64587789
114Salivary secretion_Homo sapiens_hsa049700.64455442
115Long-term depression_Homo sapiens_hsa047300.62837525
116Melanogenesis_Homo sapiens_hsa049160.62668095
117Non-small cell lung cancer_Homo sapiens_hsa052230.61474032
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61409871
119Autoimmune thyroid disease_Homo sapiens_hsa053200.61254083
120Osteoclast differentiation_Homo sapiens_hsa043800.59630206
121Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58688678
122Endocytosis_Homo sapiens_hsa041440.58343961
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57424712
124Calcium signaling pathway_Homo sapiens_hsa040200.57362312
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56953701
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56566955
127Renin secretion_Homo sapiens_hsa049240.56040115
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55811561
129Pancreatic cancer_Homo sapiens_hsa052120.55321370
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.55278119
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52958735
132Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52809755
133Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52595176
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51800469
135Colorectal cancer_Homo sapiens_hsa052100.50320929
136Choline metabolism in cancer_Homo sapiens_hsa052310.50192213
137cAMP signaling pathway_Homo sapiens_hsa040240.47517547
138FoxO signaling pathway_Homo sapiens_hsa040680.46351362
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45814647
140Inositol phosphate metabolism_Homo sapiens_hsa005620.44536381
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43939910
142N-Glycan biosynthesis_Homo sapiens_hsa005100.42517965
143Insulin signaling pathway_Homo sapiens_hsa049100.40470791
144Sphingolipid metabolism_Homo sapiens_hsa006000.40330360
145Leukocyte transendothelial migration_Homo sapiens_hsa046700.39659827
146Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37639732

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