NRG4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sequestering of triglyceride (GO:0010889)6.48214863
2biotin metabolic process (GO:0006768)5.26895436
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.13399600
4regulation of triglyceride catabolic process (GO:0010896)5.10740001
5brown fat cell differentiation (GO:0050873)5.02206865
6low-density lipoprotein particle clearance (GO:0034383)4.75772385
7triglyceride catabolic process (GO:0019433)4.75360838
8epithelial cilium movement (GO:0003351)4.66598367
9fatty acid transmembrane transport (GO:1902001)4.55901185
10fatty acid beta-oxidation (GO:0006635)4.55461646
11positive regulation of fatty acid beta-oxidation (GO:0032000)4.52865873
12piRNA metabolic process (GO:0034587)4.49951469
13valine metabolic process (GO:0006573)4.49551528
14urea metabolic process (GO:0019627)4.48913726
15urea cycle (GO:0000050)4.48913726
16cilium or flagellum-dependent cell motility (GO:0001539)4.41245818
17behavioral response to nicotine (GO:0035095)4.39876067
18acylglycerol catabolic process (GO:0046464)4.33709664
19neutral lipid catabolic process (GO:0046461)4.33709664
20positive regulation of fatty acid oxidation (GO:0046321)4.31513814
21alpha-linolenic acid metabolic process (GO:0036109)4.29330376
22cilium movement (GO:0003341)4.29074161
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.27077848
24fatty acid oxidation (GO:0019395)4.19175202
25carnitine shuttle (GO:0006853)4.16356441
26branched-chain amino acid catabolic process (GO:0009083)4.15410099
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.14800059
28L-phenylalanine catabolic process (GO:0006559)4.14800059
29positive regulation of lipid catabolic process (GO:0050996)4.14224721
30lipid storage (GO:0019915)4.14032167
31fatty acid catabolic process (GO:0009062)4.12611220
32regulation of cilium movement (GO:0003352)4.11257731
33nitrogen cycle metabolic process (GO:0071941)4.08721988
34lipid oxidation (GO:0034440)4.08612718
35acetyl-CoA metabolic process (GO:0006084)4.02726597
36axoneme assembly (GO:0035082)4.02129557
37L-phenylalanine metabolic process (GO:0006558)4.01522845
38erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.01522845
39protein polyglutamylation (GO:0018095)3.96871436
40response to pheromone (GO:0019236)3.90584859
41branched-chain amino acid metabolic process (GO:0009081)3.90332976
42triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.87656378
43complement activation, alternative pathway (GO:0006957)3.86774091
44triglyceride homeostasis (GO:0070328)3.83280043
45acylglycerol homeostasis (GO:0055090)3.83280043
46white fat cell differentiation (GO:0050872)3.73321590
47DNA methylation involved in gamete generation (GO:0043046)3.68417968
48aromatic amino acid family catabolic process (GO:0009074)3.67026964
49plasma lipoprotein particle clearance (GO:0034381)3.65828568
50NADH metabolic process (GO:0006734)3.64125110
51negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.58764627
52fatty-acyl-CoA biosynthetic process (GO:0046949)3.57916261
53amino-acid betaine metabolic process (GO:0006577)3.56918070
54negative regulation of lipase activity (GO:0060192)3.56513877
55fatty-acyl-CoA metabolic process (GO:0035337)3.56160255
56axonemal dynein complex assembly (GO:0070286)3.55375427
57triglyceride biosynthetic process (GO:0019432)3.55146612
58acylglycerol biosynthetic process (GO:0046463)3.54870277
59neutral lipid biosynthetic process (GO:0046460)3.54870277
60replication fork processing (GO:0031297)3.52509815
61acyl-CoA biosynthetic process (GO:0071616)3.52489719
62thioester biosynthetic process (GO:0035384)3.52489719
63monocarboxylic acid catabolic process (GO:0072329)3.52375932
64centriole replication (GO:0007099)3.51691064
65sulfur amino acid catabolic process (GO:0000098)3.50488674
66water-soluble vitamin biosynthetic process (GO:0042364)3.47834099
67glycerolipid catabolic process (GO:0046503)3.47405859
68multicellular organism reproduction (GO:0032504)3.46810653
69mannosylation (GO:0097502)3.44730275
70serine family amino acid catabolic process (GO:0009071)3.44190823
71bile acid biosynthetic process (GO:0006699)3.44145679
72sperm motility (GO:0030317)3.43739932
73short-chain fatty acid metabolic process (GO:0046459)3.43356370
74cerebral cortex radially oriented cell migration (GO:0021799)3.41361533
75oxaloacetate metabolic process (GO:0006107)3.40974232
76adaptation of signaling pathway (GO:0023058)3.39989819
77carnitine metabolic process (GO:0009437)3.37473207
78carnitine transmembrane transport (GO:1902603)3.36330559
79regulation of cholesterol storage (GO:0010885)3.34516411
80regulation of triglyceride metabolic process (GO:0090207)3.30643788
81RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.29057678
82triglyceride metabolic process (GO:0006641)3.28051345
83regulation of fatty acid oxidation (GO:0046320)3.28045572
84negative regulation of lipid storage (GO:0010888)3.27969709
85bile acid metabolic process (GO:0008206)3.24948824
86mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.24241993
87mitochondrial respiratory chain complex I assembly (GO:0032981)3.24241993
88NADH dehydrogenase complex assembly (GO:0010257)3.24241993
89pantothenate metabolic process (GO:0015939)3.23831641
90L-fucose catabolic process (GO:0042355)3.22183778
91fucose catabolic process (GO:0019317)3.22183778
92L-fucose metabolic process (GO:0042354)3.22183778
93long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.19670643
94cysteine metabolic process (GO:0006534)3.18254754
95acyl-CoA metabolic process (GO:0006637)3.15618813
96thioester metabolic process (GO:0035383)3.15618813
97ethanol oxidation (GO:0006069)3.15206880
98tryptophan catabolic process (GO:0006569)3.14788182
99indole-containing compound catabolic process (GO:0042436)3.14788182
100indolalkylamine catabolic process (GO:0046218)3.14788182
101NAD metabolic process (GO:0019674)3.14776050
102microtubule depolymerization (GO:0007019)3.14407488
103rRNA modification (GO:0000154)3.14081385
104coenzyme A biosynthetic process (GO:0015937)3.13800547
105long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.12673249
106retinal cone cell development (GO:0046549)3.12333149
107amino-acid betaine transport (GO:0015838)3.12270353
108carnitine transport (GO:0015879)3.12270353
109detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.12132542
110preassembly of GPI anchor in ER membrane (GO:0016254)3.11556535
111regulation of fatty acid beta-oxidation (GO:0031998)3.10393244
112acylglycerol metabolic process (GO:0006639)3.10301328
113cilium organization (GO:0044782)3.08386383
114rRNA methylation (GO:0031167)3.07547886
115intraciliary transport (GO:0042073)3.06539968
116homocysteine metabolic process (GO:0050667)3.06489421
117behavioral response to ethanol (GO:0048149)3.06265228
118lipid particle organization (GO:0034389)3.05896130
119phospholipid homeostasis (GO:0055091)3.05867665
120pyridine nucleotide biosynthetic process (GO:0019363)3.05776101
121nicotinamide nucleotide biosynthetic process (GO:0019359)3.05776101
122detection of light stimulus involved in visual perception (GO:0050908)3.05230284
123detection of light stimulus involved in sensory perception (GO:0050962)3.05230284
124coenzyme A metabolic process (GO:0015936)3.04541752
125neutral lipid metabolic process (GO:0006638)3.04457447
126positive regulation of fatty acid metabolic process (GO:0045923)3.03235727
127cilium assembly (GO:0042384)3.02896838
128positive regulation of triglyceride metabolic process (GO:0090208)3.02282443
129tryptophan metabolic process (GO:0006568)3.02116200
130protein complex biogenesis (GO:0070271)3.00280585
131regulation of protein activation cascade (GO:2000257)3.00199290
132organic acid catabolic process (GO:0016054)2.99059662
133carboxylic acid catabolic process (GO:0046395)2.99059662
134protein carboxylation (GO:0018214)2.97672455
135peptidyl-glutamic acid carboxylation (GO:0017187)2.97672455
136glycine metabolic process (GO:0006544)2.96895105
137cilium morphogenesis (GO:0060271)2.96150751
138lysine catabolic process (GO:0006554)2.94689005
139lysine metabolic process (GO:0006553)2.94689005
140cellular ketone body metabolic process (GO:0046950)2.93981451
141nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93047182
142tyrosine metabolic process (GO:0006570)2.92935152
143photoreceptor cell maintenance (GO:0045494)2.92572814
144negative regulation of mast cell activation (GO:0033004)2.91989031
145protein localization to cilium (GO:0061512)2.91661522
146regulation of meiosis I (GO:0060631)2.90695387
147exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.88388944
148male meiosis I (GO:0007141)2.83484463
149centriole assembly (GO:0098534)2.78724731
150mitochondrial respiratory chain complex assembly (GO:0033108)2.77433245
151male meiosis (GO:0007140)2.77274342
152regulation of heat generation (GO:0031650)2.75914837
153GPI anchor metabolic process (GO:0006505)2.75857320
154motile cilium assembly (GO:0044458)2.74284823
155respiratory chain complex IV assembly (GO:0008535)2.73914417
156nonmotile primary cilium assembly (GO:0035058)2.71077757
157gene silencing by RNA (GO:0031047)2.68358684
158DNA deamination (GO:0045006)2.68138931
159kynurenine metabolic process (GO:0070189)2.68039696
160substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.67877251
161substrate-independent telencephalic tangential migration (GO:0021826)2.67877251
162tachykinin receptor signaling pathway (GO:0007217)2.67541690
163resolution of meiotic recombination intermediates (GO:0000712)2.64411956
164regulation of microtubule-based movement (GO:0060632)2.63866123
165microtubule polymerization or depolymerization (GO:0031109)2.63099489
166C4-dicarboxylate transport (GO:0015740)2.61185131
167spermatid development (GO:0007286)2.60440065
168microtubule severing (GO:0051013)2.60011579
169DNA-dependent DNA replication (GO:0006261)2.58661550
170oxidative phosphorylation (GO:0006119)2.56802431
171G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.55064208
172indolalkylamine metabolic process (GO:0006586)2.53288041
173regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.53112132
174regulation of mitotic spindle checkpoint (GO:1903504)2.53112132
175left/right axis specification (GO:0070986)2.51552225
176negative regulation of DNA-dependent DNA replication (GO:2000104)2.51428105
177synapsis (GO:0007129)2.51196233
178establishment of protein localization to Golgi (GO:0072600)2.50844776
179C-terminal protein amino acid modification (GO:0018410)2.50482631
180ubiquinone biosynthetic process (GO:0006744)2.49368050
181cornea development in camera-type eye (GO:0061303)2.48677536
182maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.46906521
183negative regulation of cytosolic calcium ion concentration (GO:0051481)2.46537463
184recombinational repair (GO:0000725)2.46169844
185neuronal action potential (GO:0019228)2.45390631
186double-strand break repair via homologous recombination (GO:0000724)2.45157598
187single strand break repair (GO:0000012)2.42708535
188cellular component assembly involved in morphogenesis (GO:0010927)2.41654072
189C-terminal protein lipidation (GO:0006501)2.39358492
190meiotic cell cycle (GO:0051321)2.37486869
191cytochrome complex assembly (GO:0017004)2.37251758
192photoreceptor cell development (GO:0042461)2.36891494
193sulfation (GO:0051923)2.36477320
194acrosome reaction (GO:0007340)2.36228060
195DNA integration (GO:0015074)2.34710083
196dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.34307160
197ubiquinone metabolic process (GO:0006743)2.34140080

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.92903270
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.50600385
3E2F7_22180533_ChIP-Seq_HELA_Human6.09845166
4* RXR_22158963_ChIP-Seq_LIVER_Mouse4.88863848
5* EGR1_23403033_ChIP-Seq_LIVER_Mouse4.79569404
6PPARA_22158963_ChIP-Seq_LIVER_Mouse4.14915390
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.99979392
8* LXR_22158963_ChIP-Seq_LIVER_Mouse3.63206722
9* CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.61415055
10EZH2_22144423_ChIP-Seq_EOC_Human3.54291446
11GBX2_23144817_ChIP-Seq_PC3_Human3.25186411
12VDR_22108803_ChIP-Seq_LS180_Human3.16884414
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.11393839
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.06723496
15* CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.90110618
16ZNF274_21170338_ChIP-Seq_K562_Hela2.89640980
17* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.60586676
18TAF15_26573619_Chip-Seq_HEK293_Human2.51134997
19EWS_26573619_Chip-Seq_HEK293_Human2.47750225
20FUS_26573619_Chip-Seq_HEK293_Human2.46899371
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.45699321
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.34205704
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.32711607
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31881713
25IGF1R_20145208_ChIP-Seq_DFB_Human2.24488878
26* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.17872381
27CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11625129
28CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09137548
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.05824601
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.03655254
31P300_19829295_ChIP-Seq_ESCs_Human2.01867029
32KAP1_22055183_ChIP-Seq_ESCs_Mouse1.96706519
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.96639754
34ER_23166858_ChIP-Seq_MCF-7_Human1.94353768
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.92968645
36AR_21909140_ChIP-Seq_LNCAP_Human1.88091846
37CBP_20019798_ChIP-Seq_JUKART_Human1.80598422
38IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.80598422
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72565241
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72205245
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71380901
42HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.68413051
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.68251927
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62855917
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62029109
46* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58849294
47SMAD4_21799915_ChIP-Seq_A2780_Human1.58509111
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.57186306
49STAT3_23295773_ChIP-Seq_U87_Human1.56470948
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55853850
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55039986
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52240067
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50082700
54IRF8_22096565_ChIP-ChIP_GC-B_Human1.49894500
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.49740026
56TCF4_23295773_ChIP-Seq_U87_Human1.48866738
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48201940
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.48186187
59* TP53_22573176_ChIP-Seq_HFKS_Human1.47627082
60* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45050238
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43771126
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.42903104
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42190440
64MYC_18555785_ChIP-Seq_MESCs_Mouse1.41372110
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40746488
66* SOX2_19829295_ChIP-Seq_ESCs_Human1.40560236
67* NANOG_19829295_ChIP-Seq_ESCs_Human1.40560236
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37544325
69AR_25329375_ChIP-Seq_VCAP_Human1.35534278
70* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.34239837
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33634276
72BCAT_22108803_ChIP-Seq_LS180_Human1.32591169
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30956758
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.30919358
75TCF4_22108803_ChIP-Seq_LS180_Human1.30798528
76JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.30675859
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.30553554
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.30050074
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.29293231
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25324256
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25218437
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25050784
83RUNX2_22187159_ChIP-Seq_PCA_Human1.24604255
84MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23940295
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.22423513
86DCP1A_22483619_ChIP-Seq_HELA_Human1.20613349
87* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20296679
88BP1_19119308_ChIP-ChIP_Hs578T_Human1.19546641
89REST_21632747_ChIP-Seq_MESCs_Mouse1.18364263
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17296769
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17296769
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16223990
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15371354
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.15320683
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.15307112
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13389038
97ETV1_20927104_ChIP-Seq_GIST48_Human1.12883635
98HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12559707
99OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12065742
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11180343
101* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09750514
102FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09628485
103GABP_17652178_ChIP-ChIP_JURKAT_Human1.09396379
104P53_22387025_ChIP-Seq_ESCs_Mouse1.09297328
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09260215
106E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09176628
107ELK1_19687146_ChIP-ChIP_HELA_Human1.08431833
108TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.07988356
109* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06835013
110TP63_19390658_ChIP-ChIP_HaCaT_Human1.06670403
111MYC_18940864_ChIP-ChIP_HL60_Human1.06652282
112CRX_20693478_ChIP-Seq_RETINA_Mouse1.05363083
113NCOR_22424771_ChIP-Seq_293T_Human1.05114362
114SMAD4_21741376_ChIP-Seq_EPCs_Human1.05094547
115RNF2_27304074_Chip-Seq_NSC_Mouse1.04771025
116EST1_17652178_ChIP-ChIP_JURKAT_Human1.04662112
117MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04355198
118E2F1_21310950_ChIP-Seq_MCF-7_Human1.03273283
119HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.02927767
120AR_21572438_ChIP-Seq_LNCaP_Human1.02792856
121FOXP3_21729870_ChIP-Seq_TREG_Human1.02160006
122FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01869623
123E2F1_18555785_Chip-Seq_ESCs_Mouse1.01451240
124CLOCK_20551151_ChIP-Seq_293T_Human1.01051947
125TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01035329
126SOX2_21211035_ChIP-Seq_LN229_Gbm1.00514260
127TAL1_26923725_Chip-Seq_HPCs_Mouse1.00007616
128GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99994581
129STAT3_18555785_Chip-Seq_ESCs_Mouse0.99943336
130PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99701579
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99542599
132SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98341601
133FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98087629
134HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97355725
135CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97140644
136SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94598709
137EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.94327676
138PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93912904
139PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93762219
140ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92878002
141MYC_19030024_ChIP-ChIP_MESCs_Mouse0.92537276
142RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92246117
143SALL1_21062744_ChIP-ChIP_HESCs_Human0.91794240
144HNF4A_19822575_ChIP-Seq_HepG2_Human0.91095010
145* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89181938
146PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86522001
147IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.84647768
148SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84280525
149STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83943811
150STAT1_17558387_ChIP-Seq_HELA_Human0.83671603
151ETS1_20019798_ChIP-Seq_JURKAT_Human0.83634280
152VDR_23849224_ChIP-Seq_CD4+_Human0.82793111
153IRF1_19129219_ChIP-ChIP_H3396_Human0.81856275
154FLI1_27457419_Chip-Seq_LIVER_Mouse0.81073371
155SCL_19346495_ChIP-Seq_HPC-7_Human0.80798269
156GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80738733
157IRF8_21731497_ChIP-ChIP_J774_Mouse0.80266192
158NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.79257666
159HTT_18923047_ChIP-ChIP_STHdh_Human0.78946348
160CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.78942464
161BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77498487
162NFE2_27457419_Chip-Seq_LIVER_Mouse0.77383649
163NELFA_20434984_ChIP-Seq_ESCs_Mouse0.74387310
164PCGF2_27294783_Chip-Seq_ESCs_Mouse0.74078138
165CREB1_15753290_ChIP-ChIP_HEK293T_Human0.73938319
166CEBPB_22108803_ChIP-Seq_LS180_Human0.73794225
167FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.72276433
168GABP_19822575_ChIP-Seq_HepG2_Human0.71642701
169ERG_20517297_ChIP-Seq_VCAP_Human0.69507294
170FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.68633348
171MYC_19079543_ChIP-ChIP_MESCs_Mouse0.68488734
172CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.67986224
173ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.67788004
174ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.67426924
175SPI1_23547873_ChIP-Seq_NB4_Human0.66725016
176XRN2_22483619_ChIP-Seq_HELA_Human0.65862657
177PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.65520096
178FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.65159398
179AR_20517297_ChIP-Seq_VCAP_Human0.64352307
180SALL4_22934838_ChIP-ChIP_CD34+_Human0.64045295
181SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.63556541
182SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.63342574
183CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.63154378
184CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.62924119

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose5.91344278
2MP0002139_abnormal_hepatobiliary_system4.53235884
3MP0005360_urolithiasis4.52519405
4MP0005365_abnormal_bile_salt3.86655994
5MP0005666_abnormal_adipose_tissue3.78851289
6MP0004185_abnormal_adipocyte_glucose3.69521915
7MP0005085_abnormal_gallbladder_physiolo3.29613963
8MP0010329_abnormal_lipoprotein_level3.15513845
9MP0003011_delayed_dark_adaptation3.04125004
10MP0006292_abnormal_olfactory_placode2.92649678
11MP0000569_abnormal_digit_pigmentation2.71758282
12MP0008875_abnormal_xenobiotic_pharmacok2.71010848
13MP0004130_abnormal_muscle_cell2.62875532
14MP0002971_abnormal_brown_adipose2.60895213
15MP0008877_abnormal_DNA_methylation2.55125214
16MP0002234_abnormal_pharynx_morphology2.47502960
17MP0003191_abnormal_cellular_cholesterol2.45267805
18MP0003646_muscle_fatigue2.43206838
19MP0005551_abnormal_eye_electrophysiolog2.33189717
20MP0002653_abnormal_ependyma_morphology2.31310239
21MP0002876_abnormal_thyroid_physiology2.28816620
22MP0001968_abnormal_touch/_nociception2.27650357
23MP0002736_abnormal_nociception_after2.20341488
24MP0002118_abnormal_lipid_homeostasis2.18484290
25MP0004043_abnormal_pH_regulation2.17929354
26MP0008789_abnormal_olfactory_epithelium2.17215895
27MP0005375_adipose_tissue_phenotype2.17060665
28MP0003880_abnormal_central_pattern2.16715219
29MP0005451_abnormal_body_composition2.12539977
30MP0009697_abnormal_copulation2.10848263
31MP0000631_abnormal_neuroendocrine_gland2.04617762
32MP0003186_abnormal_redox_activity2.01330162
33MP0005646_abnormal_pituitary_gland1.98293894
34MP0009115_abnormal_fat_cell1.97093149
35MP0000609_abnormal_liver_physiology1.96786220
36MP0001984_abnormal_olfaction1.93326017
37MP0005334_abnormal_fat_pad1.91331775
38MP0006072_abnormal_retinal_apoptosis1.90596626
39MP0005332_abnormal_amino_acid1.86857864
40MP0001986_abnormal_taste_sensitivity1.85182119
41MP0005410_abnormal_fertilization1.83253009
42MP0002272_abnormal_nervous_system1.80874831
43MP0003718_maternal_effect1.76347277
44MP0006036_abnormal_mitochondrial_physio1.75263592
45MP0002970_abnormal_white_adipose1.75007270
46MP0001764_abnormal_homeostasis1.74461633
47MP0002735_abnormal_chemical_nociception1.72465547
48MP0003724_increased_susceptibility_to1.71535624
49MP0005253_abnormal_eye_physiology1.69450589
50MP0003806_abnormal_nucleotide_metabolis1.67554314
51MP0005535_abnormal_body_temperature1.65860456
52MP0002837_dystrophic_cardiac_calcinosis1.64555963
53MP0003252_abnormal_bile_duct1.62955153
54MP0009745_abnormal_behavioral_response1.62826480
55MP0005645_abnormal_hypothalamus_physiol1.61952599
56MP0009046_muscle_twitch1.59035569
57MP0005379_endocrine/exocrine_gland_phen1.56559265
58MP0005174_abnormal_tail_pigmentation1.56539956
59MP0001486_abnormal_startle_reflex1.54198354
60MP0001485_abnormal_pinna_reflex1.53698362
61MP0005394_taste/olfaction_phenotype1.53161824
62MP0005499_abnormal_olfactory_system1.53161824
63MP0003136_yellow_coat_color1.49911934
64MP0009379_abnormal_foot_pigmentation1.45475381
65MP0000372_irregular_coat_pigmentation1.42954667
66MP0003693_abnormal_embryo_hatching1.39854200
67MP0000049_abnormal_middle_ear1.37890950
68MP0005584_abnormal_enzyme/coenzyme_acti1.37883647
69MP0006276_abnormal_autonomic_nervous1.36951021
70MP0002160_abnormal_reproductive_system1.36264156
71MP0001929_abnormal_gametogenesis1.36093530
72MP0001293_anophthalmia1.36073803
73MP0001661_extended_life_span1.34797162
74MP0004019_abnormal_vitamin_homeostasis1.30274464
75MP0005319_abnormal_enzyme/_coenzyme1.29278322
76MP0005647_abnormal_sex_gland1.28633569
77MP0009840_abnormal_foam_cell1.28412420
78MP0003698_abnormal_male_reproductive1.27637658
79MP0004885_abnormal_endolymph1.26896614
80MP0002163_abnormal_gland_morphology1.24479960
81MP0003787_abnormal_imprinting1.24144123
82MP0001529_abnormal_vocalization1.23429274
83MP0002928_abnormal_bile_duct1.22237482
84MP0002095_abnormal_skin_pigmentation1.22100173
85MP0001666_abnormal_nutrient_absorption1.20990373
86MP0005448_abnormal_energy_balance1.20976541
87MP0008058_abnormal_DNA_repair1.19249220
88MP0002233_abnormal_nose_morphology1.18734881
89MP0004147_increased_porphyrin_level1.15007460
90MP0002751_abnormal_autonomic_nervous1.13588874
91MP0002210_abnormal_sex_determination1.12868458
92MP0004742_abnormal_vestibular_system1.11249565
93MP0000003_abnormal_adipose_tissue1.10828428
94MP0000778_abnormal_nervous_system1.10825906
95MP0009763_increased_sensitivity_to1.10199580
96MP0005377_hearing/vestibular/ear_phenot1.09982518
97MP0003878_abnormal_ear_physiology1.09982518
98MP0002734_abnormal_mechanical_nocicepti1.08505519
99MP0002249_abnormal_larynx_morphology1.08324033
100MP0005408_hypopigmentation1.07963551
101MP0002572_abnormal_emotion/affect_behav1.07757245
102MP0002078_abnormal_glucose_homeostasis1.07300831
103MP0004142_abnormal_muscle_tone1.07249747
104MP0001501_abnormal_sleep_pattern1.07099606
105MP0002557_abnormal_social/conspecific_i1.06904080
106MP0001970_abnormal_pain_threshold1.06060283
107MP0008995_early_reproductive_senescence1.04596230
108MP0005389_reproductive_system_phenotype1.02913585
109MP0002938_white_spotting1.02128979
110MP0005187_abnormal_penis_morphology1.00382916
111MP0002064_seizures1.00146737
112MP0004145_abnormal_muscle_electrophysio0.99862014
113MP0000653_abnormal_sex_gland0.99002548
114MP0000598_abnormal_liver_morphology0.97941116
115MP0002138_abnormal_hepatobiliary_system0.97872828
116MP0004782_abnormal_surfactant_physiolog0.97538369
117MP0002822_catalepsy0.96643333
118MP0001324_abnormal_eye_pigmentation0.96334370
119MP0005395_other_phenotype0.96179896
120MP0000613_abnormal_salivary_gland0.96138190
121MP0005452_abnormal_adipose_tissue0.95409810
122MP0001119_abnormal_female_reproductive0.93077836
123MP0001145_abnormal_male_reproductive0.92763397
124MP0001963_abnormal_hearing_physiology0.91559831
125MP0002752_abnormal_somatic_nervous0.91424978
126MP0004924_abnormal_behavior0.91338630
127MP0005386_behavior/neurological_phenoty0.91338630
128MP0004484_altered_response_of0.90877959
129MP0003635_abnormal_synaptic_transmissio0.89516737
130MP0003699_abnormal_female_reproductive0.89145246
131MP0005195_abnormal_posterior_eye0.88358646
132MP0000026_abnormal_inner_ear0.87190836
133MP0010386_abnormal_urinary_bladder0.86489097
134MP0002733_abnormal_thermal_nociception0.86174454
135MP0009643_abnormal_urine_homeostasis0.85904492
136MP0009764_decreased_sensitivity_to0.85585049
137MP0004381_abnormal_hair_follicle0.85578090
138MP0001853_heart_inflammation0.84015027
139MP0002067_abnormal_sensory_capabilities0.84010159
140MP0000013_abnormal_adipose_tissue0.83010942
141MP0002184_abnormal_innervation0.82912071
142MP0003656_abnormal_erythrocyte_physiolo0.82093719
143MP0003123_paternal_imprinting0.82062819
144MP0000383_abnormal_hair_follicle0.81731014
145MP0004133_heterotaxia0.81270923
146MP0006138_congestive_heart_failure0.80932476
147MP0005171_absent_coat_pigmentation0.80135039
148MP0005391_vision/eye_phenotype0.79478433
149MP0008469_abnormal_protein_level0.79290413
150MP0001502_abnormal_circadian_rhythm0.78944009
151MP0003868_abnormal_feces_composition0.78746342
152MP0010094_abnormal_chromosome_stability0.78549963
153MP0000427_abnormal_hair_cycle0.78387152
154MP0008872_abnormal_physiological_respon0.78260953
155MP0003436_decreased_susceptibility_to0.78256352
156MP0001881_abnormal_mammary_gland0.75765367
157MP0003959_abnormal_lean_body0.75480282
158MP0005266_abnormal_metabolism0.74982734
159MP0005464_abnormal_platelet_physiology0.73365936
160MP0005376_homeostasis/metabolism_phenot0.72597877
161MP0009642_abnormal_blood_homeostasis0.72520385
162MP0003111_abnormal_nucleus_morphology0.71579069
163MP0009765_abnormal_xenobiotic_induced0.69491058
164MP0003953_abnormal_hormone_level0.69437958
165MP0002396_abnormal_hematopoietic_system0.68356005
166MP0005397_hematopoietic_system_phenotyp0.68000842
167MP0001545_abnormal_hematopoietic_system0.68000842
168MP0005220_abnormal_exocrine_pancreas0.66945625
169MP0002638_abnormal_pupillary_reflex0.62179804
170MP0001663_abnormal_digestive_system0.61713410
171MP0001756_abnormal_urination0.61342413
172MP0005083_abnormal_biliary_tract0.61299213
173MP0009785_altered_susceptibility_to0.60782081
174MP0000490_abnormal_crypts_of0.60245658
175MP0002254_reproductive_system_inflammat0.59374473
176MP0002006_tumorigenesis0.59351373
177MP0000639_abnormal_adrenal_gland0.58603465
178MP0003195_calcinosis0.58183443
179MP0002332_abnormal_exercise_endurance0.57867914
180MP0002060_abnormal_skin_morphology0.56164852
181MP0005075_abnormal_melanosome_morpholog0.54759323
182MP0003786_premature_aging0.54128541
183MP0001845_abnormal_inflammatory_respons0.54024836
184MP0002102_abnormal_ear_morphology0.53766314

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)5.66967923
2Abnormality of glycine metabolism (HP:0010895)4.92887683
3Abnormality of serine family amino acid metabolism (HP:0010894)4.92887683
4Pancreatic cysts (HP:0001737)4.34059130
5Pancreatic fibrosis (HP:0100732)4.32038310
6Hyperglycinemia (HP:0002154)4.31558320
7Oligomenorrhea (HP:0000876)4.28906516
8Hyperammonemia (HP:0001987)4.19200405
9Intrahepatic cholestasis (HP:0001406)4.03939965
10Molar tooth sign on MRI (HP:0002419)3.95328498
11Abnormality of midbrain morphology (HP:0002418)3.95328498
12True hermaphroditism (HP:0010459)3.93326242
13Abnormality of aromatic amino acid family metabolism (HP:0004338)3.88189945
14Abnormality of fatty-acid metabolism (HP:0004359)3.87038206
15Dynein arm defect of respiratory motile cilia (HP:0012255)3.84042053
16Absent/shortened dynein arms (HP:0200106)3.84042053
17Hypoglycemic coma (HP:0001325)3.79973109
18Hypertriglyceridemia (HP:0002155)3.76196675
19Increased muscle lipid content (HP:0009058)3.70193073
20Nephronophthisis (HP:0000090)3.66845510
21Ketosis (HP:0001946)3.56687574
22Hypoalphalipoproteinemia (HP:0003233)3.54179278
23Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.52197567
24Abnormality of dicarboxylic acid metabolism (HP:0010995)3.52023392
25Dicarboxylic aciduria (HP:0003215)3.52023392
26Prolonged partial thromboplastin time (HP:0003645)3.51901301
27Complement deficiency (HP:0004431)3.49642021
28Hepatic necrosis (HP:0002605)3.43008957
29Abnormality of serum amino acid levels (HP:0003112)3.39386466
30Abnormal ciliary motility (HP:0012262)3.32561120
31Broad-based gait (HP:0002136)3.26009933
32Cerebral edema (HP:0002181)3.25479326
33Deep venous thrombosis (HP:0002625)3.23090350
34Medial flaring of the eyebrow (HP:0010747)3.21954389
35Lethargy (HP:0001254)3.20959767
36Abnormality of the renal medulla (HP:0100957)3.20366192
37Abnormality of the renal cortex (HP:0011035)3.20094912
38Abnormality of monocarboxylic acid metabolism (HP:0010996)3.18060391
39Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.17063713
40Chronic hepatic failure (HP:0100626)3.16799354
41Insulin-resistant diabetes mellitus (HP:0000831)3.16178285
42Joint hemorrhage (HP:0005261)3.16112785
43Xanthomatosis (HP:0000991)3.16097662
44Hypolipoproteinemia (HP:0010981)3.14740237
45Acanthosis nigricans (HP:0000956)3.14722699
46Epidermoid cyst (HP:0200040)3.14582071
47Abnormality of methionine metabolism (HP:0010901)3.06716498
48Abnormal respiratory motile cilium morphology (HP:0005938)3.05329643
49Abnormal respiratory epithelium morphology (HP:0012253)3.05329643
50Cystic liver disease (HP:0006706)3.04771423
51Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.04002515
52Abnormality of pyrimidine metabolism (HP:0004353)3.03985902
53Abnormal respiratory motile cilium physiology (HP:0012261)3.03279958
54Hypobetalipoproteinemia (HP:0003563)3.02908233
55Type I transferrin isoform profile (HP:0003642)3.02045875
56Hyperlipoproteinemia (HP:0010980)2.99438290
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.98203381
58Autoimmune thrombocytopenia (HP:0001973)2.97487580
59Nausea (HP:0002018)2.97412995
60Renal cortical cysts (HP:0000803)2.94284015
61Abnormality of glutamine family amino acid metabolism (HP:0010902)2.94110265
62Ketoacidosis (HP:0001993)2.93011025
63Generalized aminoaciduria (HP:0002909)2.92950626
64Attenuation of retinal blood vessels (HP:0007843)2.92142289
65Congenital stationary night blindness (HP:0007642)2.87465213
66Rhabdomyolysis (HP:0003201)2.76121485
67Acute encephalopathy (HP:0006846)2.75509284
68Lipid accumulation in hepatocytes (HP:0006561)2.75335444
69Rhinitis (HP:0012384)2.72941311
70Hyperventilation (HP:0002883)2.70765712
71Neonatal hypoglycemia (HP:0001998)2.68715821
72Reduced antithrombin III activity (HP:0001976)2.67958597
73Tubular atrophy (HP:0000092)2.63720535
74Aplasia/Hypoplasia of the tongue (HP:0010295)2.63605389
75Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.62129959
76Decreased activity of mitochondrial respiratory chain (HP:0008972)2.62129959
77Hepatocellular necrosis (HP:0001404)2.62112819
78Insulin resistance (HP:0000855)2.61169564
79Hypercholesterolemia (HP:0003124)2.59182419
80Abnormal protein glycosylation (HP:0012346)2.51496298
81Abnormal glycosylation (HP:0012345)2.51496298
82Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.51496298
83Abnormal protein N-linked glycosylation (HP:0012347)2.51496298
84Type II lissencephaly (HP:0007260)2.50621699
85Gait imbalance (HP:0002141)2.49615087
86Increased intramyocellular lipid droplets (HP:0012240)2.48904120
87Abnormality of complement system (HP:0005339)2.47059091
88Pancreatitis (HP:0001733)2.46941959
89Congenital primary aphakia (HP:0007707)2.46223870
90Proximal tubulopathy (HP:0000114)2.45161983
91Abnormality of the common coagulation pathway (HP:0010990)2.43610529
92Polydipsia (HP:0001959)2.42361459
93Abnormal drinking behavior (HP:0030082)2.42361459
94Recurrent gram-negative bacterial infections (HP:0005420)2.42220866
95Congenital hepatic fibrosis (HP:0002612)2.42017517
96Abnormality of the labia minora (HP:0012880)2.38201407
97Chromsome breakage (HP:0040012)2.37973378
98Metabolic acidosis (HP:0001942)2.36762016
99Abnormality of nucleobase metabolism (HP:0010932)2.36710131
100Focal motor seizures (HP:0011153)2.34808411
101Septo-optic dysplasia (HP:0100842)2.33462938
102Abnormality of alanine metabolism (HP:0010916)2.32603461
103Hyperalaninemia (HP:0003348)2.32603461
104Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32603461
105Postaxial foot polydactyly (HP:0001830)2.31648008
106Spontaneous abortion (HP:0005268)2.31237452
107Lactic acidosis (HP:0003128)2.31210655
108Abnormal hemoglobin (HP:0011902)2.30174214
109Gaze-evoked nystagmus (HP:0000640)2.29678954
110Long foot (HP:0001833)2.29641536
111Sclerocornea (HP:0000647)2.29588838
112Brushfield spots (HP:0001088)2.29234957
113Abnormal rod and cone electroretinograms (HP:0008323)2.28748371
114Hydroxyprolinuria (HP:0003080)2.28728626
115Abnormality of proline metabolism (HP:0010907)2.28728626
116Pendular nystagmus (HP:0012043)2.27534933
117Myocardial infarction (HP:0001658)2.25897428
118Thyroid-stimulating hormone excess (HP:0002925)2.25709189
119Occipital encephalocele (HP:0002085)2.24848712
120Decreased central vision (HP:0007663)2.23976757
121Increased hepatocellular lipid droplets (HP:0006565)2.22975815
122Abolished electroretinogram (ERG) (HP:0000550)2.22583369
123Anencephaly (HP:0002323)2.22560161
124Elevated hepatic transaminases (HP:0002910)2.21280405
125Abnormality of sulfur amino acid metabolism (HP:0004339)2.20762668
126Aplasia/Hypoplasia of the tibia (HP:0005772)2.19388045
127Genital tract atresia (HP:0001827)2.19231330
128Nephrogenic diabetes insipidus (HP:0009806)2.18482699
129Increased CSF lactate (HP:0002490)2.17846633
130Hyperglycemia (HP:0003074)2.17817193
131Oligodactyly (hands) (HP:0001180)2.17083719
132Abnormal mitochondria in muscle tissue (HP:0008316)2.16782022
133Vomiting (HP:0002013)2.15993866
134Abnormality of the intrinsic pathway (HP:0010989)2.15155239
135Abnormality of lateral ventricle (HP:0030047)2.13714748
136Abnormality of glycolysis (HP:0004366)2.13142633
137Increased serum pyruvate (HP:0003542)2.13142633
138Glycosuria (HP:0003076)2.13123071
139Abnormality of urine glucose concentration (HP:0011016)2.13123071
140Bony spicule pigmentary retinopathy (HP:0007737)2.12062187
141Methylmalonic acidemia (HP:0002912)2.11502036
142Respiratory difficulties (HP:0002880)2.09370897
143Progressive inability to walk (HP:0002505)2.09304168
144Bile duct proliferation (HP:0001408)2.09098791
145Abnormal biliary tract physiology (HP:0012439)2.09098791
146Abnormality of macular pigmentation (HP:0008002)2.09048119
147Mitochondrial inheritance (HP:0001427)2.06708680
148Acute necrotizing encephalopathy (HP:0006965)2.06686135
149Vaginal atresia (HP:0000148)2.05738930
150Polyuria (HP:0000103)2.04731237
151Optic nerve hypoplasia (HP:0000609)2.04621976
152Postaxial hand polydactyly (HP:0001162)2.04430105
153Supernumerary spleens (HP:0009799)2.03223651
154Abnormality of purine metabolism (HP:0004352)2.03072246
155Aplastic anemia (HP:0001915)2.02823411
156Renal Fanconi syndrome (HP:0001994)2.01868594
157Fat malabsorption (HP:0002630)2.01064737
158Cerebellar dysplasia (HP:0007033)2.00694453
159Furrowed tongue (HP:0000221)2.00254806
1603-Methylglutaconic aciduria (HP:0003535)1.99112027
161Hypergonadotropic hypogonadism (HP:0000815)1.99018441
162Chromosomal breakage induced by crosslinking agents (HP:0003221)1.98280984
163Cortical dysplasia (HP:0002539)1.95883777
164Inability to walk (HP:0002540)1.95432813
165Azoospermia (HP:0000027)1.95152759
166Progressive macrocephaly (HP:0004481)1.94780196
167Aplasia/Hypoplasia of the uvula (HP:0010293)1.94751232
168Decreased electroretinogram (ERG) amplitude (HP:0000654)1.93752141
169Pachygyria (HP:0001302)1.93681162
170Febrile seizures (HP:0002373)1.93509835
171Lissencephaly (HP:0001339)1.91019770
172Male pseudohermaphroditism (HP:0000037)1.90289994
173Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88565209
174Tubulointerstitial nephritis (HP:0001970)1.87089831
175Short tibia (HP:0005736)1.86103379
176Colon cancer (HP:0003003)1.82196743
177Long nose (HP:0003189)1.81449225
178Conical tooth (HP:0000698)1.78532972
179Preaxial hand polydactyly (HP:0001177)1.78484540
180Poor coordination (HP:0002370)1.78026301
181Absent speech (HP:0001344)1.74013318
182Abnormality of the ileum (HP:0001549)1.73811330
183Severe visual impairment (HP:0001141)1.73115642
184Growth hormone deficiency (HP:0000824)1.72565499

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.60932182
2CAMK1D3.76361066
3ERBB43.10805278
4MAP4K23.03220120
5MAP3K62.88849032
6BMPR1B2.82238404
7CDK82.69155555
8EIF2AK12.68212942
9TAOK32.66163193
10IRAK32.46632383
11ADRBK22.32887879
12CAMK1G2.30145530
13BRAF2.27934364
14TNIK2.22628168
15WNK32.19939097
16PDK32.17524931
17PDK42.17524931
18WEE12.06677726
19MAP3K132.03380924
20TTK2.00425402
21STK38L1.87272210
22GRK11.83134729
23SIK11.82131258
24MAPK111.77576066
25LATS11.75499469
26PRKAA21.70195895
27MST1R1.69542830
28PLK41.68562109
29STK391.65675749
30LMTK21.65522512
31MAPK131.65227058
32CDK91.59529435
33OXSR11.58032304
34CDK41.55608042
35NEK91.53590993
36ACVR1B1.53277466
37ABL21.51879282
38TLK11.47986846
39BCR1.45322117
40EIF2AK21.40574351
41PBK1.39906175
42WNK41.37489574
43MUSK1.37114658
44PLK21.27872105
45CDK31.22436136
46CDK61.19538889
47MAPK151.19530038
48TEC1.18830277
49BUB11.14447229
50BRSK21.14153715
51MAP3K41.12996249
52CASK1.12333671
53SRPK11.12292603
54ERN11.11692534
55TRIM281.08259478
56OBSCN1.08074403
57TAOK11.04841855
58NLK1.04130230
59MST41.02423959
60NME11.01687568
61TYK21.01177849
62AKT30.96182657
63PRKCE0.94852493
64PDK20.94469174
65DYRK20.94203287
66MAPKAPK50.93536602
67IRAK40.92376603
68MAP2K70.91395820
69VRK20.91390819
70MKNK10.90778121
71CHEK20.90686143
72MARK10.90636830
73PLK10.90132797
74NME20.89838965
75FGFR40.87654272
76TIE10.87596094
77FLT30.86620218
78BMPR20.86191213
79CSNK1G30.85991310
80IRAK10.85688728
81FRK0.84917440
82ADRBK10.84019337
83MAPK40.82880806
84TRIB30.82336852
85INSRR0.82122137
86LATS20.82053095
87ARAF0.81738378
88CAMK2A0.81414532
89PHKG10.80511585
90PHKG20.80511585
91PRKCG0.80243727
92STK160.79400933
93TGFBR20.79231967
94NEK20.79112817
95CDK70.78540118
96JAK20.78184880
97ERBB30.77552242
98KIT0.76999031
99CSNK1G20.76052930
100TGFBR10.72968961
101FGFR30.71398985
102EPHA40.71281608
103CAMKK20.71143472
104GRK50.70169788
105PIK3CG0.69276865
106VRK10.67642008
107CDC70.66440437
108DMPK0.65945196
109AURKB0.65885433
110MAP3K80.64870039
111ATR0.64685418
112MKNK20.64283153
113PAK30.64066523
114CSNK1A1L0.62383996
115RAF10.62252868
116EEF2K0.62194164
117PINK10.62070955
118MAP3K140.61534486
119SGK20.60691366
120TXK0.59952038
121PRKAA10.59717166
122CSF1R0.59302326
123IKBKB0.56435181
124PRKCQ0.55533599
125STK380.52814958
126CSNK1G10.50397360
127MOS0.49661018
128DYRK30.48873108
129PTK2B0.48275663
130PLK30.48158136
131STK30.48138704
132CCNB10.47898671
133NUAK10.47469823
134STK110.46181413
135ATM0.46096748
136CDC42BPA0.45907890
137PRKACA0.45825262
138NEK60.44819600
139JAK30.44579419
140NTRK30.44100589
141MAP4K10.42706393
142CSNK1A10.41744531
143MAP2K60.40921915
144NTRK20.40869277
145EPHA30.40592752
146SGK4940.40492023
147SGK2230.40492023
148DAPK20.40051188
149RPS6KA40.39293972
150PNCK0.38932659
151RPS6KA50.38582258
152PKN10.38241527
153BTK0.36868196
154EIF2AK30.35813185
155JAK10.35601664
156PDK10.34935904
157MAPKAPK30.34244115
158PDPK10.32952451
159TRPM70.30977188
160AURKA0.30906704
161ZAK0.30367305
162ABL10.30190783
163CSNK2A10.27339980
164MELK0.26365001
165MAP3K50.23931221

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.54048090
2Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.21701081
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.21626878
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.09267434
5Fatty acid degradation_Homo sapiens_hsa000713.06693536
6PPAR signaling pathway_Homo sapiens_hsa033203.01291916
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.94944810
8Fatty acid metabolism_Homo sapiens_hsa012122.83243866
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55859460
10Phototransduction_Homo sapiens_hsa047442.38033032
11Fatty acid biosynthesis_Homo sapiens_hsa000612.31722694
12Nicotine addiction_Homo sapiens_hsa050332.29205355
13Peroxisome_Homo sapiens_hsa041462.19744901
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.18742113
15Pyruvate metabolism_Homo sapiens_hsa006202.16441228
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.14968085
17beta-Alanine metabolism_Homo sapiens_hsa004102.03413664
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.97246741
19Vitamin B6 metabolism_Homo sapiens_hsa007501.94056762
20Tryptophan metabolism_Homo sapiens_hsa003801.93002881
21Arginine biosynthesis_Homo sapiens_hsa002201.90423569
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.87790449
23Fatty acid elongation_Homo sapiens_hsa000621.87568990
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.81549070
25Taste transduction_Homo sapiens_hsa047421.80235196
26Nitrogen metabolism_Homo sapiens_hsa009101.79635625
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.79322040
28Complement and coagulation cascades_Homo sapiens_hsa046101.74399907
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69563402
30Butanoate metabolism_Homo sapiens_hsa006501.65378623
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.62716609
32Ether lipid metabolism_Homo sapiens_hsa005651.61498526
33Glycerolipid metabolism_Homo sapiens_hsa005611.60596873
34Olfactory transduction_Homo sapiens_hsa047401.57535338
35Carbon metabolism_Homo sapiens_hsa012001.56942114
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.55242960
37Retinol metabolism_Homo sapiens_hsa008301.53906592
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.50192357
39Staphylococcus aureus infection_Homo sapiens_hsa051501.46390696
40Regulation of autophagy_Homo sapiens_hsa041401.45866081
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.37846737
42Homologous recombination_Homo sapiens_hsa034401.34712531
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.33174186
44Histidine metabolism_Homo sapiens_hsa003401.32615739
45Caffeine metabolism_Homo sapiens_hsa002321.31911020
46Phenylalanine metabolism_Homo sapiens_hsa003601.31177282
47Tyrosine metabolism_Homo sapiens_hsa003501.29320186
48Morphine addiction_Homo sapiens_hsa050321.29094309
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28494446
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25438823
51Pentose phosphate pathway_Homo sapiens_hsa000301.24265293
52Steroid hormone biosynthesis_Homo sapiens_hsa001401.21841933
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.18662358
54Chemical carcinogenesis_Homo sapiens_hsa052041.17049689
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.16545359
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.15173519
57Selenocompound metabolism_Homo sapiens_hsa004501.14552679
58DNA replication_Homo sapiens_hsa030301.10544196
59Fat digestion and absorption_Homo sapiens_hsa049751.08282697
60One carbon pool by folate_Homo sapiens_hsa006701.07446286
61Alzheimers disease_Homo sapiens_hsa050101.06827384
62Folate biosynthesis_Homo sapiens_hsa007901.06600391
63Cysteine and methionine metabolism_Homo sapiens_hsa002701.02892053
64ABC transporters_Homo sapiens_hsa020101.01273616
65Biosynthesis of amino acids_Homo sapiens_hsa012300.99918241
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99065831
67Mismatch repair_Homo sapiens_hsa034300.96252359
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94605759
69Circadian rhythm_Homo sapiens_hsa047100.94144084
70Cardiac muscle contraction_Homo sapiens_hsa042600.89576887
71Pancreatic secretion_Homo sapiens_hsa049720.85748353
72RNA transport_Homo sapiens_hsa030130.85284920
73Pyrimidine metabolism_Homo sapiens_hsa002400.85250301
74Starch and sucrose metabolism_Homo sapiens_hsa005000.85211710
75Ribosome_Homo sapiens_hsa030100.85071678
76RNA polymerase_Homo sapiens_hsa030200.84725445
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83894839
78Glutamatergic synapse_Homo sapiens_hsa047240.83536695
79Circadian entrainment_Homo sapiens_hsa047130.82916927
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.81832772
81GABAergic synapse_Homo sapiens_hsa047270.81177348
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79987114
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76227121
84Fanconi anemia pathway_Homo sapiens_hsa034600.75977138
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74711917
86Glutathione metabolism_Homo sapiens_hsa004800.73215622
87Insulin secretion_Homo sapiens_hsa049110.72082545
88Metabolic pathways_Homo sapiens_hsa011000.69494570
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69463189
90AMPK signaling pathway_Homo sapiens_hsa041520.69358665
91Salivary secretion_Homo sapiens_hsa049700.67393322
92N-Glycan biosynthesis_Homo sapiens_hsa005100.66291678
93Proteasome_Homo sapiens_hsa030500.64466323
94Lysine degradation_Homo sapiens_hsa003100.63799776
95Serotonergic synapse_Homo sapiens_hsa047260.59685228
96Asthma_Homo sapiens_hsa053100.59383826
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57805616
98Calcium signaling pathway_Homo sapiens_hsa040200.57626143
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55591629
100Oocyte meiosis_Homo sapiens_hsa041140.54813533
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.54787826
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.54680967
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52980590
104Base excision repair_Homo sapiens_hsa034100.52720850
105Sulfur metabolism_Homo sapiens_hsa009200.51919216
106Nucleotide excision repair_Homo sapiens_hsa034200.50765718
107Linoleic acid metabolism_Homo sapiens_hsa005910.50466042
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47696624
109Non-homologous end-joining_Homo sapiens_hsa034500.47248461
110RNA degradation_Homo sapiens_hsa030180.46216343
111Cell cycle_Homo sapiens_hsa041100.46138539
112Steroid biosynthesis_Homo sapiens_hsa001000.45486479
113Arginine and proline metabolism_Homo sapiens_hsa003300.45214083
114Vitamin digestion and absorption_Homo sapiens_hsa049770.45195932
115Oxidative phosphorylation_Homo sapiens_hsa001900.44824288
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.43697558
117Cocaine addiction_Homo sapiens_hsa050300.43401042
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43056713
119Huntingtons disease_Homo sapiens_hsa050160.41860316
120Arachidonic acid metabolism_Homo sapiens_hsa005900.41316368
121Collecting duct acid secretion_Homo sapiens_hsa049660.41035605
122Dopaminergic synapse_Homo sapiens_hsa047280.40823796
123Insulin resistance_Homo sapiens_hsa049310.39912805
124Amphetamine addiction_Homo sapiens_hsa050310.39718411
125Ovarian steroidogenesis_Homo sapiens_hsa049130.39531259
126Purine metabolism_Homo sapiens_hsa002300.37665080
127Hedgehog signaling pathway_Homo sapiens_hsa043400.37627109
128Glucagon signaling pathway_Homo sapiens_hsa049220.35016523
129Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.33574788
130Sulfur relay system_Homo sapiens_hsa041220.33055756
131Parkinsons disease_Homo sapiens_hsa050120.28373713
132Basal transcription factors_Homo sapiens_hsa030220.27819922
133Protein export_Homo sapiens_hsa030600.25828201
134Insulin signaling pathway_Homo sapiens_hsa049100.22678518
135Cyanoamino acid metabolism_Homo sapiens_hsa004600.22143335
136Bile secretion_Homo sapiens_hsa049760.21443386
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20190750

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