NRGN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.50024628
2synaptic vesicle maturation (GO:0016188)6.44568513
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.44039070
4locomotory exploration behavior (GO:0035641)6.18980105
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.98950619
6vocalization behavior (GO:0071625)5.95846061
7synaptic vesicle exocytosis (GO:0016079)5.86409584
8glutamate secretion (GO:0014047)5.84902059
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.67089729
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.66601159
11regulation of glutamate receptor signaling pathway (GO:1900449)5.57015150
12regulation of synaptic vesicle exocytosis (GO:2000300)5.34308506
13protein localization to synapse (GO:0035418)5.24107049
14regulation of long-term neuronal synaptic plasticity (GO:0048169)5.17020886
15neuronal action potential propagation (GO:0019227)5.16854074
16regulation of neuronal synaptic plasticity (GO:0048168)5.12433227
17ionotropic glutamate receptor signaling pathway (GO:0035235)5.01977368
18regulation of synaptic vesicle transport (GO:1902803)4.83689523
19exploration behavior (GO:0035640)4.81984809
20regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.71791092
21cerebellar granule cell differentiation (GO:0021707)4.69663381
22dendritic spine morphogenesis (GO:0060997)4.66499036
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.54522782
24regulation of synapse structural plasticity (GO:0051823)4.49562287
25glutamate receptor signaling pathway (GO:0007215)4.48880861
26regulation of dendritic spine morphogenesis (GO:0061001)4.48709295
27synaptic transmission, glutamatergic (GO:0035249)4.46039004
28regulation of excitatory postsynaptic membrane potential (GO:0060079)4.40684309
29neurotransmitter secretion (GO:0007269)4.39097483
30layer formation in cerebral cortex (GO:0021819)4.33161979
31neurotransmitter-gated ion channel clustering (GO:0072578)4.32946424
32positive regulation of membrane potential (GO:0045838)4.32798095
33G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.32290784
34amino acid import (GO:0043090)4.31638951
35long-term memory (GO:0007616)4.27981625
36neuron cell-cell adhesion (GO:0007158)4.24020459
37regulation of synaptic plasticity (GO:0048167)4.22108250
38neuron-neuron synaptic transmission (GO:0007270)4.18813973
39regulation of postsynaptic membrane potential (GO:0060078)4.11727981
40negative regulation of dendrite morphogenesis (GO:0050774)4.11205370
41positive regulation of neurotransmitter secretion (GO:0001956)4.07112818
42long-term synaptic potentiation (GO:0060291)3.89460774
43dendritic spine organization (GO:0097061)3.86061613
44regulation of dendritic spine development (GO:0060998)3.85435548
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.82814067
46positive regulation of synapse maturation (GO:0090129)3.82470221
47cerebellar Purkinje cell differentiation (GO:0021702)3.78540748
48positive regulation of neurotransmitter transport (GO:0051590)3.76180095
49cellular potassium ion homeostasis (GO:0030007)3.75366462
50regulation of neurotransmitter secretion (GO:0046928)3.68372225
51synaptic vesicle endocytosis (GO:0048488)3.65746743
52positive regulation of dendritic spine development (GO:0060999)3.61657665
53neuromuscular process controlling balance (GO:0050885)3.59556212
54gamma-aminobutyric acid signaling pathway (GO:0007214)3.58932164
55potassium ion homeostasis (GO:0055075)3.56782492
56regulation of vesicle fusion (GO:0031338)3.56180353
57vesicle docking involved in exocytosis (GO:0006904)3.55881470
58positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.55443556
59central nervous system myelination (GO:0022010)3.55401781
60axon ensheathment in central nervous system (GO:0032291)3.55401781
61activation of protein kinase A activity (GO:0034199)3.55216162
62regulation of synapse maturation (GO:0090128)3.52830803
63neuron recognition (GO:0008038)3.51334579
64potassium ion import (GO:0010107)3.50501766
65negative regulation of synaptic transmission, GABAergic (GO:0032229)3.48827158
66positive regulation of dendritic spine morphogenesis (GO:0061003)3.48242062
67proline transport (GO:0015824)3.48129896
68neurotransmitter transport (GO:0006836)3.46926351
69regulation of synaptic transmission, glutamatergic (GO:0051966)3.46302248
70gamma-aminobutyric acid transport (GO:0015812)3.37640489
71regulation of exocytosis (GO:0017157)3.37106372
72regulation of neurotransmitter transport (GO:0051588)3.36407451
73sodium ion export (GO:0071436)3.35573768
74transmission of nerve impulse (GO:0019226)3.35033408
75behavioral fear response (GO:0001662)3.34731596
76behavioral defense response (GO:0002209)3.34731596
77membrane depolarization (GO:0051899)3.33657174
78chemosensory behavior (GO:0007635)3.32508354
79regulation of voltage-gated calcium channel activity (GO:1901385)3.32440394
80cell communication by electrical coupling (GO:0010644)3.32079563
81regulation of neurotransmitter levels (GO:0001505)3.27558421
82negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.27117956
83regulation of glutamate secretion (GO:0014048)3.25701379
84learning (GO:0007612)3.25330385
85auditory behavior (GO:0031223)3.24630405
86cytoskeletal anchoring at plasma membrane (GO:0007016)3.23401365
87long term synaptic depression (GO:0060292)3.23090369
88regulation of synaptic transmission (GO:0050804)3.22431081
89regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.22302854
90positive regulation of synaptic transmission (GO:0050806)3.21878375
91neuromuscular process controlling posture (GO:0050884)3.21295094
92behavioral response to cocaine (GO:0048148)3.20742622
93fear response (GO:0042596)3.19281052
94vesicle docking (GO:0048278)3.18562256
95postsynaptic membrane organization (GO:0001941)3.16602623
96acidic amino acid transport (GO:0015800)3.15731961
97axonal fasciculation (GO:0007413)3.15156780
98response to histamine (GO:0034776)3.15121002
99L-amino acid import (GO:0043092)3.14606959
100positive regulation of synaptic transmission, GABAergic (GO:0032230)3.14098424
101negative regulation of amino acid transport (GO:0051956)3.10917135
102membrane depolarization during action potential (GO:0086010)3.08718783
103establishment of synaptic vesicle localization (GO:0097480)3.07754773
104synaptic vesicle transport (GO:0048489)3.07754773
105intraspecies interaction between organisms (GO:0051703)3.07020500
106social behavior (GO:0035176)3.07020500
107G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.06910183
108presynaptic membrane assembly (GO:0097105)3.06289023
109neuronal ion channel clustering (GO:0045161)3.06187227
110response to auditory stimulus (GO:0010996)3.05198635
111membrane hyperpolarization (GO:0060081)3.04148153
112regulation of female receptivity (GO:0045924)3.03631124
113positive regulation of fibroblast migration (GO:0010763)3.03387365
114synaptic transmission (GO:0007268)3.02425946
115cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.02392152
116phosphorelay signal transduction system (GO:0000160)3.01294591
117regulation of ARF protein signal transduction (GO:0032012)3.01258061
118neurotransmitter uptake (GO:0001504)3.00304447
119positive regulation of exocytosis (GO:0045921)2.98885600
120detection of calcium ion (GO:0005513)2.98261967
121prepulse inhibition (GO:0060134)2.96093177
122innervation (GO:0060384)2.95990703
123neuromuscular process (GO:0050905)2.94386993
124cell differentiation in hindbrain (GO:0021533)2.93493959
125positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.93257313
126cellular sodium ion homeostasis (GO:0006883)2.91205169
127neuromuscular synaptic transmission (GO:0007274)2.89129371
128dicarboxylic acid transport (GO:0006835)2.87729778
129positive regulation of dendrite development (GO:1900006)2.87235440

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.69761821
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.36506470
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.35075784
4GBX2_23144817_ChIP-Seq_PC3_Human3.30716587
5* RARB_27405468_Chip-Seq_BRAIN_Mouse3.24575880
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.19258675
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.92369446
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.92369446
9REST_21632747_ChIP-Seq_MESCs_Mouse2.91830837
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.85830023
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.80307433
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.69192254
13DROSHA_22980978_ChIP-Seq_HELA_Human2.67547442
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.65784689
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.63397734
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.61821668
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.56274036
18IKZF1_21737484_ChIP-ChIP_HCT116_Human2.43677560
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.41439705
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.36586196
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.35965372
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.33912245
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.31702791
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.30603430
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06091492
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.90966000
27AR_21572438_ChIP-Seq_LNCaP_Human1.82623318
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79017687
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.78742742
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72869295
31LXR_22292898_ChIP-Seq_THP-1_Human1.67923158
32* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66501033
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59826162
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59054755
35* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.56003534
36TAF15_26573619_Chip-Seq_HEK293_Human1.55266695
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54487209
38SRY_22984422_ChIP-ChIP_TESTIS_Rat1.51179543
39SMAD4_21799915_ChIP-Seq_A2780_Human1.48676326
40DNAJC2_21179169_ChIP-ChIP_NT2_Human1.40872717
41RING1B_27294783_Chip-Seq_ESCs_Mouse1.40181712
42RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.39745097
43SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39213232
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31946696
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.29578268
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28744872
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28681795
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27246394
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24607550
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.22914685
51* SOX2_21211035_ChIP-Seq_LN229_Gbm1.20502475
52P300_19829295_ChIP-Seq_ESCs_Human1.20465021
53ZNF274_21170338_ChIP-Seq_K562_Hela1.20432376
54* KDM2B_26808549_Chip-Seq_DND41_Human1.20048135
55* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19926045
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.19617909
57* KDM2B_26808549_Chip-Seq_K562_Human1.18871197
58* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18792403
59OCT4_19829295_ChIP-Seq_ESCs_Human1.18338257
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17172284
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16791521
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.16074797
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14927922
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14770607
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14654536
66AR_25329375_ChIP-Seq_VCAP_Human1.14622082
67RING1B_27294783_Chip-Seq_NPCs_Mouse1.14426482
68AR_19668381_ChIP-Seq_PC3_Human1.14409229
69SMC4_20622854_ChIP-Seq_HELA_Human1.14032088
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13129752
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12175478
72P68_20966046_ChIP-Seq_HELA_Human1.09056162
73PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09035058
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07935688
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06754711
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06458143
77KLF4_19829295_ChIP-Seq_ESCs_Human1.06268999
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.04425435
79DPY_21335234_ChIP-Seq_ESCs_Mouse1.03788762
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02906906
81STAT3_23295773_ChIP-Seq_U87_Human1.02828954
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01967478
83RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01916797
84SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01229083
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01199693
86KDM2B_26808549_Chip-Seq_JURKAT_Human1.01126456
87OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99763965
88TP53_16413492_ChIP-PET_HCT116_Human0.99107499
89THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98622522
90PRDM14_20953172_ChIP-Seq_ESCs_Human0.97576945
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97502859
92ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96378186
93SMAD3_21741376_ChIP-Seq_HESCs_Human0.96161302
94CREB1_26743006_Chip-Seq_LNCaP_Human0.95883470
95MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95599018
96TCF4_23295773_ChIP-Seq_U87_Human0.94861338
97CBX2_27304074_Chip-Seq_ESCs_Mouse0.94752200
98ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94596455
99RXR_22108803_ChIP-Seq_LS180_Human0.94450128
100YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93519299
101TCF7_22412390_ChIP-Seq_EML_Mouse0.92681451
102EGR1_19032775_ChIP-ChIP_M12_Human0.91411969
103CTCF_27219007_Chip-Seq_Bcells_Human0.91281012
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91117710
105PIAS1_25552417_ChIP-Seq_VCAP_Human0.91105462
106TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91029201
107ARNT_22903824_ChIP-Seq_MCF-7_Human0.90751767
108ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89799849
109CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89262928
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89223955
111SMAD3_21741376_ChIP-Seq_ESCs_Human0.88627265
112SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86219921
113NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85155093
114* TET1_21490601_ChIP-Seq_MESCs_Mouse0.84859130
115UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.84799129
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84613654
117SMAD4_21741376_ChIP-Seq_ESCs_Human0.84610971
118FUS_26573619_Chip-Seq_HEK293_Human0.84317415
119GATA1_26923725_Chip-Seq_HPCs_Mouse0.84280758
120TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84204050
121CTCF_27219007_Chip-Seq_ERYTHROID_Human0.84135474
122RUNX2_22187159_ChIP-Seq_PCA_Human0.83546922
123BMI1_23680149_ChIP-Seq_NPCS_Mouse0.83210734
124JUN_21703547_ChIP-Seq_K562_Human0.83138408
125TET1_21451524_ChIP-Seq_MESCs_Mouse0.82703240
126* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82663520
127RNF2_27304074_Chip-Seq_NSC_Mouse0.82391101
128* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.82318428
129SMAD4_21741376_ChIP-Seq_HESCs_Human0.81841062
130AHR_22903824_ChIP-Seq_MCF-7_Human0.81354919
131GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81280260
132SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.80767932
133GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.79911577
134SA1_27219007_Chip-Seq_Bcells_Human0.79567114
135KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.79016584
136MYC_19915707_ChIP-ChIP_AK7_Human0.77385310
137SA1_27219007_Chip-Seq_ERYTHROID_Human0.76986132
138DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.76074316
139CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.74170576
140GATA1_19941826_ChIP-Seq_K562_Human0.73394947
141SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.72719099
142MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.71664657

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0004859_abnormal_synaptic_plasticity7.51372350
2MP0003880_abnormal_central_pattern5.56972738
3* MP0003635_abnormal_synaptic_transmissio4.56867870
4MP0004270_analgesia3.95608686
5MP0009745_abnormal_behavioral_response3.79802242
6* MP0002063_abnormal_learning/memory/cond3.69911559
7MP0002822_catalepsy3.45227049
8MP0002064_seizures3.39822038
9MP0001968_abnormal_touch/_nociception3.08531061
10MP0002572_abnormal_emotion/affect_behav2.98751684
11MP0009046_muscle_twitch2.81293493
12MP0001486_abnormal_startle_reflex2.72969914
13MP0002272_abnormal_nervous_system2.68694364
14MP0001501_abnormal_sleep_pattern2.52853151
15MP0002734_abnormal_mechanical_nocicepti2.46160938
16MP0005423_abnormal_somatic_nervous2.39930174
17MP0002736_abnormal_nociception_after2.37398484
18MP0001440_abnormal_grooming_behavior2.22259862
19MP0009780_abnormal_chondrocyte_physiolo2.09156112
20MP0003329_amyloid_beta_deposits2.05751264
21MP0002735_abnormal_chemical_nociception1.90345499
22MP0008569_lethality_at_weaning1.89975930
23MP0001970_abnormal_pain_threshold1.87654164
24MP0003879_abnormal_hair_cell1.86428479
25MP0002733_abnormal_thermal_nociception1.85141180
26MP0004811_abnormal_neuron_physiology1.80065413
27MP0002067_abnormal_sensory_capabilities1.78802943
28MP0004858_abnormal_nervous_system1.75581180
29MP0002557_abnormal_social/conspecific_i1.68942858
30MP0002909_abnormal_adrenal_gland1.67089010
31MP0004924_abnormal_behavior1.62983036
32MP0005386_behavior/neurological_phenoty1.62983036
33MP0000778_abnormal_nervous_system1.53986815
34MP0002184_abnormal_innervation1.50834680
35MP0005646_abnormal_pituitary_gland1.48551324
36MP0003075_altered_response_to1.46495095
37MP0003633_abnormal_nervous_system1.45636611
38MP0000955_abnormal_spinal_cord1.40585393
39MP0002066_abnormal_motor_capabilities/c1.40463338
40MP0003123_paternal_imprinting1.39282800
41MP0001984_abnormal_olfaction1.35142946
42MP0002882_abnormal_neuron_morphology1.32032593
43MP0004885_abnormal_endolymph1.30128226
44MP0001905_abnormal_dopamine_level1.29546760
45MP0003787_abnormal_imprinting1.26455506
46MP0001529_abnormal_vocalization1.25450529
47MP0008872_abnormal_physiological_respon1.21548417
48MP0003631_nervous_system_phenotype1.18696709
49MP0001502_abnormal_circadian_rhythm1.16250551
50MP0008874_decreased_physiological_sensi1.15824328
51MP0003172_abnormal_lysosome_physiology1.11195112
52MP0004510_myositis1.09420384
53MP0005464_abnormal_platelet_physiology1.06031279
54MP0003183_abnormal_peptide_metabolism1.05933476
55MP0002152_abnormal_brain_morphology1.04208626
56MP0006276_abnormal_autonomic_nervous1.01680371
57MP0005535_abnormal_body_temperature0.99345849
58MP0000604_amyloidosis0.98432551
59MP0000751_myopathy0.97828345
60MP0001188_hyperpigmentation0.96701249
61MP0002069_abnormal_eating/drinking_beha0.96582300
62MP0005167_abnormal_blood-brain_barrier0.96359553
63MP0004130_abnormal_muscle_cell0.94482801
64MP0010234_abnormal_vibrissa_follicle0.93777951
65MP0002837_dystrophic_cardiac_calcinosis0.91667726
66MP0001986_abnormal_taste_sensitivity0.91118680
67MP0004145_abnormal_muscle_electrophysio0.90163278
68MP0001177_atelectasis0.90014869
69MP0004142_abnormal_muscle_tone0.87845006
70MP0005409_darkened_coat_color0.86900064
71MP0008961_abnormal_basal_metabolism0.86292484
72MP0000013_abnormal_adipose_tissue0.85311609
73MP0001346_abnormal_lacrimal_gland0.84328087
74MP0005645_abnormal_hypothalamus_physiol0.83680320
75MP0004484_altered_response_of0.82705244
76MP0010386_abnormal_urinary_bladder0.82377711
77MP0000920_abnormal_myelination0.80309821
78MP0002229_neurodegeneration0.78981886
79MP0004085_abnormal_heartbeat0.78907804
80MP0003303_peritoneal_inflammation0.76762844
81MP0001963_abnormal_hearing_physiology0.75274327
82MP0001664_abnormal_digestion0.72407601
83MP0002090_abnormal_vision0.71785448
84MP0003690_abnormal_glial_cell0.71504815
85MP0004742_abnormal_vestibular_system0.71102433
86MP0003632_abnormal_nervous_system0.68796782
87MP0005166_decreased_susceptibility_to0.68077021
88MP0005394_taste/olfaction_phenotype0.67268624
89MP0005499_abnormal_olfactory_system0.67268624
90MP0005551_abnormal_eye_electrophysiolog0.67099141
91MP0001348_abnormal_lacrimal_gland0.63972245
92MP0004147_increased_porphyrin_level0.63957992
93MP0004215_abnormal_myocardial_fiber0.63540315
94MP0002876_abnormal_thyroid_physiology0.61637492
95MP0001485_abnormal_pinna_reflex0.61534399
96MP0003634_abnormal_glial_cell0.61319135
97MP0003283_abnormal_digestive_organ0.60936094
98MP0003045_fibrosis0.59469012
99MP0000631_abnormal_neuroendocrine_gland0.58702575
100MP0001765_abnormal_ion_homeostasis0.57475994
101MP0008260_abnormal_autophagy0.56676877
102MP0008004_abnormal_stomach_pH0.56523661
103MP0005623_abnormal_meninges_morphology0.56474898
104MP0002752_abnormal_somatic_nervous0.54055662
105MP0008877_abnormal_DNA_methylation0.53736968
106MP0003122_maternal_imprinting0.52298367
107MP0002638_abnormal_pupillary_reflex0.50158962
108MP0005310_abnormal_salivary_gland0.50118841
109MP0002133_abnormal_respiratory_system0.49580186
110MP0005388_respiratory_system_phenotype0.49580186
111MP0003956_abnormal_body_size0.49182229
112MP0001943_abnormal_respiration0.48540355
113MP0004233_abnormal_muscle_weight0.47667191
114MP0010769_abnormal_survival0.47473457
115MP0002873_normal_phenotype0.46653794
116MP0003137_abnormal_impulse_conducting0.45544661
117MP0002234_abnormal_pharynx_morphology0.45534031
118MP0002169_no_abnormal_phenotype0.45070565
119MP0010768_mortality/aging0.44589239
120MP0002083_premature_death0.41193965
121MP0002089_abnormal_postnatal_growth/wei0.40804898
122MP0003638_abnormal_response/metabolism_0.39539912
123MP0001851_eye_inflammation0.38922194

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.99776851
2Myokymia (HP:0002411)8.03909690
3Focal seizures (HP:0007359)6.49148744
4Visual hallucinations (HP:0002367)5.97906820
5Epileptic encephalopathy (HP:0200134)5.54195216
6Atonic seizures (HP:0010819)5.22537396
7Febrile seizures (HP:0002373)4.78989363
8Absence seizures (HP:0002121)4.63308469
9Dialeptic seizures (HP:0011146)4.25652973
10Generalized tonic-clonic seizures (HP:0002069)4.23915337
11Poor eye contact (HP:0000817)4.10195256
12Progressive cerebellar ataxia (HP:0002073)3.97217099
13Broad-based gait (HP:0002136)3.84962236
14Action tremor (HP:0002345)3.84308794
15Impaired vibration sensation in the lower limbs (HP:0002166)3.82381667
16Amblyopia (HP:0000646)3.79803286
17Tetraplegia (HP:0002445)3.66651858
18Hyperventilation (HP:0002883)3.63282509
19Gaze-evoked nystagmus (HP:0000640)3.56944860
20Impaired social interactions (HP:0000735)3.56907367
21Abnormal social behavior (HP:0012433)3.56907367
22Depression (HP:0000716)3.51608171
23Anxiety (HP:0000739)3.41639647
24Supranuclear gaze palsy (HP:0000605)3.41261340
25Neuronal loss in central nervous system (HP:0002529)3.40696564
26Dysmetria (HP:0001310)3.39745601
27Dysdiadochokinesis (HP:0002075)3.31407444
28Ankle clonus (HP:0011448)3.25647196
29Cerebral hypomyelination (HP:0006808)3.22638055
30Urinary bladder sphincter dysfunction (HP:0002839)3.21145305
31Papilledema (HP:0001085)3.12265677
32Postural instability (HP:0002172)3.08676812
33Annular pancreas (HP:0001734)3.07519013
34Stereotypic behavior (HP:0000733)2.98437352
35Cerebral inclusion bodies (HP:0100314)2.98431894
36Abnormality of the lower motor neuron (HP:0002366)2.97467954
37Impaired smooth pursuit (HP:0007772)2.94959901
38Truncal ataxia (HP:0002078)2.92067385
39Limb dystonia (HP:0002451)2.86021285
40Urinary urgency (HP:0000012)2.82797632
41Torticollis (HP:0000473)2.81104593
42Abnormal eating behavior (HP:0100738)2.80679991
43Focal dystonia (HP:0004373)2.76776241
44Neurofibrillary tangles (HP:0002185)2.71474184
45Impaired vibratory sensation (HP:0002495)2.65936224
46Akinesia (HP:0002304)2.65417149
47Bradykinesia (HP:0002067)2.65208596
48Delusions (HP:0000746)2.61304498
49Hemiparesis (HP:0001269)2.60428907
50Peripheral hypomyelination (HP:0007182)2.59407267
51Genetic anticipation (HP:0003743)2.58222527
52Status epilepticus (HP:0002133)2.57775098
53Abnormality of binocular vision (HP:0011514)2.57243652
54Diplopia (HP:0000651)2.57243652
55Megalencephaly (HP:0001355)2.55576657
56Mutism (HP:0002300)2.54831389
57Epileptiform EEG discharges (HP:0011182)2.53390621
58Excessive salivation (HP:0003781)2.52246103
59Drooling (HP:0002307)2.52246103
60Scanning speech (HP:0002168)2.51444563
61Diminished motivation (HP:0000745)2.51139553
62Ventricular fibrillation (HP:0001663)2.49610919
63Absent speech (HP:0001344)2.49591904
64Intention tremor (HP:0002080)2.48492342
65Spastic gait (HP:0002064)2.45394715
66Abnormality of ocular smooth pursuit (HP:0000617)2.43418992
67Dysmetric saccades (HP:0000641)2.42373041
68Craniofacial dystonia (HP:0012179)2.37310665
69EEG with generalized epileptiform discharges (HP:0011198)2.36817624
70Hemiplegia (HP:0002301)2.34789483
71Generalized myoclonic seizures (HP:0002123)2.33536424
72Pointed chin (HP:0000307)2.32295317
73Prolonged bleeding time (HP:0003010)2.30833854
74Progressive inability to walk (HP:0002505)2.29845081
75Inability to walk (HP:0002540)2.29554551
76Memory impairment (HP:0002354)2.28839886
77Termporal pattern (HP:0011008)2.25199916
78Insidious onset (HP:0003587)2.25199916
79Sleep apnea (HP:0010535)2.23766029
80Bundle branch block (HP:0011710)2.22993293
81Hypsarrhythmia (HP:0002521)2.21220407
82Ankyloglossia (HP:0010296)2.20785449
83Abnormality of the corticospinal tract (HP:0002492)2.20081981
84Obstructive sleep apnea (HP:0002870)2.19526956
85Spastic tetraparesis (HP:0001285)2.18525384
86Lower limb asymmetry (HP:0100559)2.18196915
87Incomplete penetrance (HP:0003829)2.18147964
88Slow saccadic eye movements (HP:0000514)2.15136334
89Resting tremor (HP:0002322)2.15037777
90Spinal canal stenosis (HP:0003416)2.14439263
91Choreoathetosis (HP:0001266)2.10027845
92Polyphagia (HP:0002591)2.09880354
93Lower limb amyotrophy (HP:0007210)2.06097447
94Dementia (HP:0000726)2.05851802
95Purpura (HP:0000979)2.05296933
96Lower limb muscle weakness (HP:0007340)2.02969272
97Abnormality of the periventricular white matter (HP:0002518)2.02365811
98Fetal akinesia sequence (HP:0001989)2.01723212
99Gait ataxia (HP:0002066)2.00782497
100Insomnia (HP:0100785)1.98279487
101Rapidly progressive (HP:0003678)1.97387850
102Menorrhagia (HP:0000132)1.90190667
103Hydroureter (HP:0000072)1.87447063
104Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.86669844
105Degeneration of the lateral corticospinal tracts (HP:0002314)1.86669844
106CNS hypomyelination (HP:0003429)1.84920906
107Psychosis (HP:0000709)1.82700461
108Protruding tongue (HP:0010808)1.82348183
109Ocular albinism (HP:0001107)1.81731590
110Split foot (HP:0001839)1.81123239
111Rigidity (HP:0002063)1.80541296
112Thickened helices (HP:0000391)1.80482481
113Iris hypopigmentation (HP:0007730)1.79325698
114Deep palmar crease (HP:0006191)1.78721877
115Apathy (HP:0000741)1.77846272
116Abnormality of salivation (HP:0100755)1.77068077
117Morphological abnormality of the pyramidal tract (HP:0002062)1.76693617
118Abnormal platelet volume (HP:0011876)1.76233847
119Achilles tendon contracture (HP:0001771)1.74696544
120Truncus arteriosus (HP:0001660)1.73819908
121Petechiae (HP:0000967)1.72885614
122Deeply set eye (HP:0000490)1.72208485
123Abnormal EKG (HP:0003115)1.71284844
124Blue irides (HP:0000635)1.70770094
125Palpebral edema (HP:0100540)1.69909617
126Abnormality of saccadic eye movements (HP:0000570)1.69736988
127Clonus (HP:0002169)1.69629459
128Heart block (HP:0012722)1.69412882
129Increased circulating renin level (HP:0000848)1.69237364
130Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.68705872
131Inappropriate behavior (HP:0000719)1.67823998

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.16899052
2NTRK34.30604389
3MAP3K93.70834608
4DAPK23.38485118
5RIPK43.37418090
6MAP3K42.65443662
7PRKD32.50713797
8KSR22.49092389
9MINK12.46944154
10PAK62.37520555
11MAP2K72.25619093
12DAPK12.16860359
13CAMKK12.04356250
14MAP3K122.01505924
15MAP2K41.75524976
16ARAF1.75075209
17KSR11.73002659
18MAP3K131.72303125
19NTRK11.69494986
20PLK21.69298246
21CDK191.67405092
22CDK51.58619903
23SIK21.53777593
24MARK11.51550270
25GRK51.47846389
26PRPF4B1.45816283
27NTRK21.44371676
28FES1.43645920
29BMPR21.42510804
30MAP3K111.36604066
31PNCK1.32530317
32STK381.29456910
33RAF11.27505255
34PTK2B1.24855893
35MAP3K21.24516262
36CASK1.18733157
37TYRO31.17128320
38TAOK11.16733266
39CAMK11.09406212
40TNIK1.08749115
41UHMK10.97565344
42CAMKK20.92088030
43CAMK2A0.91674285
44* PRKCG0.91054167
45PINK10.88640044
46STK110.88243066
47CCNB10.87866344
48CDK180.85555470
49CDK150.84665539
50NME10.82249217
51PDK10.81993069
52CDK140.80534329
53PDPK10.77219579
54DAPK30.76745702
55MAPK130.75800166
56CDK11A0.75533188
57CAMK2B0.75201245
58MAP3K10.72190230
59PRKCH0.71705614
60RET0.69362617
61OXSR10.68756058
62TNK20.66315019
63SGK10.65349754
64FGR0.63309885
65ALK0.62453482
66PKN10.61931207
67SGK2230.61566579
68SGK4940.61566579
69MAP3K70.57877310
70PAK30.56104669
71MARK20.55488975
72DYRK1A0.55080448
73BMX0.54971195
74LATS20.53601261
75SYK0.53355517
76PRKG20.50480304
77DMPK0.50042349
78IRAK20.49979907
79MAP2K10.48966937
80JAK20.47552428
81CAMK40.46870764
82BRSK10.46525052
83SGK30.45971172
84SGK20.45310988
85TAOK20.45056389
86RPS6KA30.42626153
87PRKCZ0.41686317
88TESK10.41252553
89JAK10.40926182
90LIMK10.40416201
91PRKD20.39308455
92FYN0.38869755
93BRAF0.38516896
94NEK60.37338884
95MAP2K60.37118054
96MAPK100.37081301
97MOS0.36523367
98RIPK10.35266878
99PRKCE0.34558606
100CAMK2G0.34052811
101MAPK120.33562067
102* PRKCA0.32029005
103CAMK2D0.31541540
104FER0.31343686
105CAMK1G0.30853608
106CSNK1G20.30565713
107NEK10.30481154
108PAK10.30015554
109GRK60.29840449
110MAP3K60.28582401
111ERBB20.27773072
112ROCK20.26366841
113LMTK20.25808018
114PHKG20.25041017
115PHKG10.25041017
116SRC0.23820597
117MAPK40.22705638
118ROCK10.21535506

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.45730969
2Synaptic vesicle cycle_Homo sapiens_hsa047213.13995171
3Long-term potentiation_Homo sapiens_hsa047203.04535646
4Olfactory transduction_Homo sapiens_hsa047402.98008707
5Circadian entrainment_Homo sapiens_hsa047132.79419005
6Amphetamine addiction_Homo sapiens_hsa050312.71073275
7Glutamatergic synapse_Homo sapiens_hsa047242.68298362
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.67033951
9Morphine addiction_Homo sapiens_hsa050322.47679565
10GABAergic synapse_Homo sapiens_hsa047272.47244364
11Salivary secretion_Homo sapiens_hsa049702.43128134
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.24672395
13Dopaminergic synapse_Homo sapiens_hsa047282.19367906
14Gastric acid secretion_Homo sapiens_hsa049712.12106319
15Insulin secretion_Homo sapiens_hsa049112.02280642
16Aldosterone synthesis and secretion_Homo sapiens_hsa049252.01740274
17Cholinergic synapse_Homo sapiens_hsa047251.94375661
18Oxytocin signaling pathway_Homo sapiens_hsa049211.88794446
19Renin secretion_Homo sapiens_hsa049241.86307457
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.76177865
21Calcium signaling pathway_Homo sapiens_hsa040201.74975016
22Long-term depression_Homo sapiens_hsa047301.70545913
23GnRH signaling pathway_Homo sapiens_hsa049121.61978312
24Taste transduction_Homo sapiens_hsa047421.58267370
25Serotonergic synapse_Homo sapiens_hsa047261.51707903
26Cocaine addiction_Homo sapiens_hsa050301.50501586
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41576758
28Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.39468302
29Vitamin B6 metabolism_Homo sapiens_hsa007501.37762515
30Collecting duct acid secretion_Homo sapiens_hsa049661.37662025
31Gap junction_Homo sapiens_hsa045401.35819111
32Glioma_Homo sapiens_hsa052141.34351161
33cAMP signaling pathway_Homo sapiens_hsa040241.30444638
34Nitrogen metabolism_Homo sapiens_hsa009101.26511492
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19123214
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18985075
37Estrogen signaling pathway_Homo sapiens_hsa049151.16937799
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15904205
39Melanogenesis_Homo sapiens_hsa049161.12840727
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12273466
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05770112
42ErbB signaling pathway_Homo sapiens_hsa040121.03977051
43Vascular smooth muscle contraction_Homo sapiens_hsa042701.03068040
44Type II diabetes mellitus_Homo sapiens_hsa049301.02546317
45Cardiac muscle contraction_Homo sapiens_hsa042601.00245884
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99969558
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98779134
48Oocyte meiosis_Homo sapiens_hsa041140.96633425
49Axon guidance_Homo sapiens_hsa043600.93315385
50VEGF signaling pathway_Homo sapiens_hsa043700.92475616
51Pancreatic secretion_Homo sapiens_hsa049720.91719820
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87486515
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86820602
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.85794958
55Vibrio cholerae infection_Homo sapiens_hsa051100.78574009
56Dorso-ventral axis formation_Homo sapiens_hsa043200.78285098
57Thyroid hormone synthesis_Homo sapiens_hsa049180.77940123
58Choline metabolism in cancer_Homo sapiens_hsa052310.76071345
59Phototransduction_Homo sapiens_hsa047440.75334332
60African trypanosomiasis_Homo sapiens_hsa051430.70072084
61MAPK signaling pathway_Homo sapiens_hsa040100.68843631
62Dilated cardiomyopathy_Homo sapiens_hsa054140.67415741
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67063183
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.66420008
65Glucagon signaling pathway_Homo sapiens_hsa049220.66416000
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65538211
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61801351
68Rap1 signaling pathway_Homo sapiens_hsa040150.61498998
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.60261604
70Non-small cell lung cancer_Homo sapiens_hsa052230.56532694
71Ras signaling pathway_Homo sapiens_hsa040140.56486341
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52104053
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51457008
74mTOR signaling pathway_Homo sapiens_hsa041500.50785910
75Alzheimers disease_Homo sapiens_hsa050100.49226663
76Inositol phosphate metabolism_Homo sapiens_hsa005620.47572652
77Endocytosis_Homo sapiens_hsa041440.46921148
78Alcoholism_Homo sapiens_hsa050340.43998768
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43354151
80Prion diseases_Homo sapiens_hsa050200.42938507
81B cell receptor signaling pathway_Homo sapiens_hsa046620.42685299
82Bile secretion_Homo sapiens_hsa049760.42439981
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42138203
84Type I diabetes mellitus_Homo sapiens_hsa049400.41954159
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41948154
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40317224
87Wnt signaling pathway_Homo sapiens_hsa043100.39749769
88Chemokine signaling pathway_Homo sapiens_hsa040620.39252387
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37351866
90Tuberculosis_Homo sapiens_hsa051520.37142901
91Renal cell carcinoma_Homo sapiens_hsa052110.35981768
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35563711
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33420135
94Osteoclast differentiation_Homo sapiens_hsa043800.33314474
95HIF-1 signaling pathway_Homo sapiens_hsa040660.33274875
96Circadian rhythm_Homo sapiens_hsa047100.32724888
97Platelet activation_Homo sapiens_hsa046110.32421709
98Insulin signaling pathway_Homo sapiens_hsa049100.31854425
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30760839
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29595336
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29179169
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28611645
103Endometrial cancer_Homo sapiens_hsa052130.27709171
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.25053942
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24525715
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24397475
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23728329
108T cell receptor signaling pathway_Homo sapiens_hsa046600.23622390
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23387690
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.22155959

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