NRIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.33740072
2interkinetic nuclear migration (GO:0022027)5.24613461
3carnitine transmembrane transport (GO:1902603)4.97980523
4endothelium development (GO:0003158)4.91008018
5definitive hemopoiesis (GO:0060216)4.82313916
6carnitine transport (GO:0015879)4.76957700
7amino-acid betaine transport (GO:0015838)4.76957700
8monoubiquitinated protein deubiquitination (GO:0035520)4.72749967
9epithelial cell differentiation involved in kidney development (GO:0035850)4.44977899
10carnitine shuttle (GO:0006853)4.37519478
11positive regulation of vasculogenesis (GO:2001214)4.26464957
12aggressive behavior (GO:0002118)4.21428784
13urate metabolic process (GO:0046415)4.09562304
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.08107695
15negative regulation of cell killing (GO:0031342)4.08107695
16positive regulation of gamma-delta T cell activation (GO:0046645)3.96365816
17CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.95743693
18T-helper cell differentiation (GO:0042093)3.95743693
19quaternary ammonium group transport (GO:0015697)3.80385166
20CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.75249338
21thyroid gland development (GO:0030878)3.70502968
22face development (GO:0060324)3.70377234
23fatty acid transmembrane transport (GO:1902001)3.66765616
24CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.65158824
25regulation of gamma-delta T cell differentiation (GO:0045586)3.64056338
26cellular response to antibiotic (GO:0071236)3.61065104
27negative regulation of granulocyte differentiation (GO:0030853)3.58925664
28response to vitamin E (GO:0033197)3.57708827
29interferon-gamma production (GO:0032609)3.57394157
30response to interleukin-15 (GO:0070672)3.54225053
31glycoprotein catabolic process (GO:0006516)3.52066974
32alpha-beta T cell differentiation (GO:0046632)3.51206468
33thrombin receptor signaling pathway (GO:0070493)3.48444738
34regulation of erythrocyte differentiation (GO:0045646)3.48158690
35antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.45662415
36antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.45662415
37regulation of integrin activation (GO:0033623)3.45253494
38alpha-beta T cell activation (GO:0046631)3.44656660
39negative regulation of nitric oxide biosynthetic process (GO:0045019)3.44251180
40regulation of sarcomere organization (GO:0060297)3.42999959
41positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.42847906
42growth hormone receptor signaling pathway (GO:0060396)3.42762863
43embryonic viscerocranium morphogenesis (GO:0048703)3.38986144
44regulation of interleukin-12 biosynthetic process (GO:0045075)3.37052810
45alpha-beta T cell differentiation involved in immune response (GO:0002293)3.36378050
46alpha-beta T cell activation involved in immune response (GO:0002287)3.36378050
47T cell differentiation involved in immune response (GO:0002292)3.36378050
48cellular response to interleukin-15 (GO:0071350)3.34656490
49regulation of alkaline phosphatase activity (GO:0010692)3.33518879
50regulation of gamma-delta T cell activation (GO:0046643)3.30519815
51negative T cell selection (GO:0043383)3.29387127
52regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.29323242
53stress granule assembly (GO:0034063)3.26863330
54cellular response to fluid shear stress (GO:0071498)3.23613376
55positive regulation of natural killer cell differentiation (GO:0032825)3.22961760
56CD4-positive, alpha-beta T cell activation (GO:0035710)3.21946068
57regulation of regulatory T cell differentiation (GO:0045589)3.21609759
58tolerance induction (GO:0002507)3.21117481
59lymph node development (GO:0048535)3.19510531
60intracellular lipid transport (GO:0032365)3.14765182
61JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.13169768
62positive T cell selection (GO:0043368)3.12043579
63regulation of histone H3-K9 methylation (GO:0051570)3.10856848
64megakaryocyte development (GO:0035855)3.09903108
65cellular response to osmotic stress (GO:0071470)3.09329130
66negative thymic T cell selection (GO:0045060)3.08870816
67cartilage morphogenesis (GO:0060536)3.07618663
68T cell differentiation (GO:0030217)3.07503641
69cellular response to growth hormone stimulus (GO:0071378)3.03033805
70T cell selection (GO:0045058)3.01861067
71hepatocyte differentiation (GO:0070365)3.01561178
72antigen processing and presentation of endogenous antigen (GO:0019883)3.00814911
73mature B cell differentiation (GO:0002335)3.00586601
74hemopoiesis (GO:0030097)2.99822305
75embryonic hemopoiesis (GO:0035162)2.98591773
76positive regulation of cardiac muscle hypertrophy (GO:0010613)2.98428843
77positive regulation of muscle hypertrophy (GO:0014742)2.98428843
78cellular response to ethanol (GO:0071361)2.97574288
79tyrosine phosphorylation of STAT protein (GO:0007260)2.97553350
80segment specification (GO:0007379)2.97346757
81T cell lineage commitment (GO:0002360)2.96585115
82ribosome assembly (GO:0042255)2.96152144
83cellular response to arsenic-containing substance (GO:0071243)2.96039448
84mature B cell differentiation involved in immune response (GO:0002313)2.94991412
85negative regulation of erythrocyte differentiation (GO:0045647)2.94921421
86positive regulation of cell size (GO:0045793)2.91234372
87G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.90527201
88hepatocyte apoptotic process (GO:0097284)2.90090212
89embryonic process involved in female pregnancy (GO:0060136)2.88840069
90myeloid dendritic cell activation (GO:0001773)2.87037610
91epithelial cell maturation (GO:0002070)2.86813983
92regulation of T cell tolerance induction (GO:0002664)2.86200992
93receptor recycling (GO:0001881)2.85581882
94response to muramyl dipeptide (GO:0032495)2.84358538
95antigen processing and presentation via MHC class Ib (GO:0002475)2.83020045
96T cell homeostasis (GO:0043029)2.82588498
97regulation of vasculogenesis (GO:2001212)2.82134550
98regulation of establishment of cell polarity (GO:2000114)2.80707965
99positive regulation of nitric-oxide synthase activity (GO:0051000)2.80265853
100activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.78479385
101positive regulation of B cell differentiation (GO:0045579)2.77667431
102heparin metabolic process (GO:0030202)2.77154374
103heparin biosynthetic process (GO:0030210)2.77154374
104regulation of chronic inflammatory response (GO:0002676)2.76749447
105histone H3-K9 demethylation (GO:0033169)2.76177782
106positive regulation of transforming growth factor beta production (GO:0071636)2.73328854
107phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.72436870
108positive thymic T cell selection (GO:0045059)2.70823411
109poly(A)+ mRNA export from nucleus (GO:0016973)2.70801787
110mucosal-associated lymphoid tissue development (GO:0048537)2.68329578
111Peyers patch development (GO:0048541)2.68329578
112dentate gyrus development (GO:0021542)2.68286899
113pinocytosis (GO:0006907)2.67712183
114positive regulation of erythrocyte differentiation (GO:0045648)2.66761402
115thymic T cell selection (GO:0045061)2.66721580
116regulation of B cell receptor signaling pathway (GO:0050855)2.66617320
117regulation of granulocyte differentiation (GO:0030852)2.66309627
118B cell homeostasis (GO:0001782)2.66175262
119negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.65742621
120regulation of T cell mediated cytotoxicity (GO:0001914)2.65127534
121lymphoid progenitor cell differentiation (GO:0002320)2.64694963
122hypotonic response (GO:0006971)2.63109767
123positive regulation of granulocyte differentiation (GO:0030854)2.60803113
124negative regulation of protein autophosphorylation (GO:0031953)2.59766250
125lymphocyte differentiation (GO:0030098)2.58486260
126negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.57607173
127negative regulation of B cell proliferation (GO:0030889)2.57596645
128regulation of female receptivity (GO:0045924)2.57232783
129negative regulation of DNA repair (GO:0045738)2.56483451
130bundle of His cell to Purkinje myocyte communication (GO:0086069)2.55231870
131regulation of B cell proliferation (GO:0030888)2.55007508
132energy homeostasis (GO:0097009)2.54032075
133T cell differentiation in thymus (GO:0033077)2.53944995
134neuron remodeling (GO:0016322)2.53650551
135regulation of transforming growth factor beta2 production (GO:0032909)2.53235994
136nerve growth factor signaling pathway (GO:0038180)2.51976425
137positive regulation of B cell proliferation (GO:0030890)2.50832179
138Rap protein signal transduction (GO:0032486)2.50354294
139positive regulation of T cell mediated cytotoxicity (GO:0001916)2.50189526
140positive regulation of macrophage differentiation (GO:0045651)2.50048117
141positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.49670458
142regulation of B cell differentiation (GO:0045577)2.49547368
143myeloid dendritic cell differentiation (GO:0043011)2.48791181
144positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.48144416
145regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.48144416
146negative regulation of neurotransmitter secretion (GO:0046929)2.47855522
147positive regulation of respiratory burst (GO:0060267)2.47041936
148regulation of cardiac muscle hypertrophy (GO:0010611)2.46836983
149negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.46261941
150lymphocyte homeostasis (GO:0002260)2.45374549
151regulation of natural killer cell differentiation (GO:0032823)2.45073486
152cranial nerve morphogenesis (GO:0021602)2.44913321
153negative regulation of T-helper cell differentiation (GO:0045623)2.44635936
154negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.44635936
155negative regulation of gluconeogenesis (GO:0045721)2.44003877
156negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.42701074
157regulation of T cell receptor signaling pathway (GO:0050856)2.42116601
158mitotic sister chromatid cohesion (GO:0007064)2.41695710
159regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.41644325
160regulation of germinal center formation (GO:0002634)2.41539742
161hemidesmosome assembly (GO:0031581)2.41260337
162positive regulation of protein import into nucleus, translocation (GO:0033160)2.41108504
163dendritic cell chemotaxis (GO:0002407)2.40877972
164angiogenesis involved in wound healing (GO:0060055)2.40828902
165regulation of muscle hypertrophy (GO:0014743)2.40343203
166germinal center formation (GO:0002467)2.40178367
167cell morphogenesis involved in neuron differentiation (GO:0048667)2.39977468
168positive regulation of phosphatase activity (GO:0010922)2.39849583
169cellular response to thyroid hormone stimulus (GO:0097067)2.39702948
170regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.39510233
171dendritic cell migration (GO:0036336)2.38588624
172peptidyl-lysine dimethylation (GO:0018027)2.38581184
173response to type I interferon (GO:0034340)2.38310958
174positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)2.38239886
175negative regulation of osteoclast differentiation (GO:0045671)2.37284883
176regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.35360296
177T cell activation involved in immune response (GO:0002286)2.34742327
178regulation of interferon-beta biosynthetic process (GO:0045357)2.34536856
179dosage compensation (GO:0007549)2.34307373
180positive regulation of cell cycle G1/S phase transition (GO:1902808)2.34266275
181negative regulation of thymocyte apoptotic process (GO:0070244)2.34201526
182melanocyte differentiation (GO:0030318)2.34047479
183positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.32854260
184positive regulation of protein homodimerization activity (GO:0090073)2.31467001
185regulation of transforming growth factor beta production (GO:0071634)2.30926664
186regulation of establishment or maintenance of cell polarity (GO:0032878)2.28787628

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.00587166
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.92218333
3STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.09611888
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.01190192
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.00174260
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.93363245
7SCL_19346495_ChIP-Seq_HPC-7_Human2.89922832
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.88271547
9RUNX_20019798_ChIP-Seq_JUKART_Human2.87871005
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.73156408
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.65895067
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.61900211
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.54914494
14* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.44412269
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.31528022
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.27404396
17GATA1_22025678_ChIP-Seq_K562_Human2.24984071
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.17471473
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.16805948
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03776277
21NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.95495606
22NRF2_20460467_ChIP-Seq_MEFs_Mouse1.95495606
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.94240381
24* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.90055776
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.85070974
26MYB_26560356_Chip-Seq_TH2_Human1.84686562
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.84560506
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.82099798
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81350068
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.78821308
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.73800429
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.64191347
33* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63489419
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.62152799
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.58367436
36* VDR_24787735_ChIP-Seq_THP-1_Human1.56704816
37ESR1_15608294_ChIP-ChIP_MCF-7_Human1.55588042
38CDX2_20551321_ChIP-Seq_CACO-2_Human1.49962562
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.47518462
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46759400
41* TCF7_22412390_ChIP-Seq_EML_Mouse1.44927207
42RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.44890972
43MYB_26560356_Chip-Seq_TH1_Human1.44503178
44FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.40449378
45TCF4_18268006_ChIP-ChIP_LS174T_Human1.40004957
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38818883
47TAF15_26573619_Chip-Seq_HEK293_Human1.38268754
48SALL4_18804426_ChIP-ChIP_XEN_Mouse1.37172215
49TP53_16413492_ChIP-PET_HCT116_Human1.35933309
50CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.34833909
51ER_23166858_ChIP-Seq_MCF-7_Human1.34665718
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.33340561
53* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31773393
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30301837
55IRF8_21731497_ChIP-ChIP_J774_Mouse1.29975763
56* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29305387
57EP300_21415370_ChIP-Seq_HL-1_Mouse1.25511240
58MAF_26560356_Chip-Seq_TH1_Human1.22765368
59CDX2_22108803_ChIP-Seq_LS180_Human1.21696598
60CJUN_26792858_Chip-Seq_BT549_Human1.20125965
61CLOCK_20551151_ChIP-Seq_293T_Human1.19857736
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19511095
63PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19473864
64ZNF263_19887448_ChIP-Seq_K562_Human1.18633225
65* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18070169
66TP63_23658742_ChIP-Seq_EP156T_Human1.17738355
67FOXO3_23340844_ChIP-Seq_DLD1_Human1.17641057
68TP53_18474530_ChIP-ChIP_U2OS_Human1.17542333
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14813372
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14091736
71* VDR_24763502_ChIP-Seq_THP-1_Human1.13192320
72LXR_22158963_ChIP-Seq_LIVER_Mouse1.13147956
73FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.13016083
74* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12430552
75FOXA2_19822575_ChIP-Seq_HepG2_Human1.11834619
76IGF1R_20145208_ChIP-Seq_DFB_Human1.11606835
77SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11585322
78SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11585322
79RXR_22108803_ChIP-Seq_LS180_Human1.11218924
80BCAT_22108803_ChIP-Seq_LS180_Human1.11088284
81* BRD4_25478319_ChIP-Seq_HGPS_Human1.09873997
82GATA2_19941826_ChIP-Seq_K562_Human1.09852795
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.09682725
84GATA3_27048872_Chip-Seq_THYMUS_Human1.09532751
85TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09334750
86CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09159499
87* AHR_22903824_ChIP-Seq_MCF-7_Human1.07536964
88* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07267969
89* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07227420
90* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07081508
91FLI1_21867929_ChIP-Seq_TH2_Mouse1.05495095
92* ESR1_21235772_ChIP-Seq_MCF-7_Human1.04436842
93NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04040869
94P300_19829295_ChIP-Seq_ESCs_Human1.03761650
95TRIM28_21343339_ChIP-Seq_HEK293_Human1.03338569
96* ARNT_22903824_ChIP-Seq_MCF-7_Human1.03034958
97RUNX1_22412390_ChIP-Seq_EML_Mouse1.01723024
98* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01701998
99* PU_27001747_Chip-Seq_BMDM_Mouse1.01554247
100STAT3_23295773_ChIP-Seq_U87_Human1.01170522
101AR_21572438_ChIP-Seq_LNCaP_Human1.00928535
102GBX2_23144817_ChIP-Seq_PC3_Human0.99587833
103* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99293275
104* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98720448
105SPI1_23127762_ChIP-Seq_K562_Human0.98368653
106SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98220237
107HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97452570
108ESR1_20079471_ChIP-ChIP_T-47D_Human0.97080214
109KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96591667
110BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95956906
111SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94683632
112RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94407053
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94075746
114LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93985242
115PRDM14_20953172_ChIP-Seq_ESCs_Human0.93691455
116* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93455043
117OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93204223
118PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93196524
119AR_25329375_ChIP-Seq_VCAP_Human0.91766409
120FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.91435951
121ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90260653
122* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90099988
123* SMAD4_21799915_ChIP-Seq_A2780_Human0.90099485
124SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89130025
125EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88391207
126* SOX2_20726797_ChIP-Seq_SW620_Human0.87605912
127GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87582100
128GATA1_19941826_ChIP-Seq_K562_Human0.87272268
129NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86225758
130* ESR2_21235772_ChIP-Seq_MCF-7_Human0.86017169
131SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.84588665
132EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84460124
133* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.83720066
134FUS_26573619_Chip-Seq_HEK293_Human0.83519659
135EWS_26573619_Chip-Seq_HEK293_Human0.83260147

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000013_abnormal_adipose_tissue3.72568908
2MP0002166_altered_tumor_susceptibility3.22228590
3MP0003724_increased_susceptibility_to3.18650756
4MP0002009_preneoplasia3.00103991
5MP0005671_abnormal_response_to2.97836929
6MP0001835_abnormal_antigen_presentation2.80891476
7MP0001873_stomach_inflammation2.78977403
8MP0003763_abnormal_thymus_physiology2.77050971
9MP0008057_abnormal_DNA_replication2.72388211
10MP0003300_gastrointestinal_ulcer2.64977618
11MP0002006_tumorigenesis2.62207233
12MP0004084_abnormal_cardiac_muscle2.31347905
13MP0003183_abnormal_peptide_metabolism2.24296694
14MP0003191_abnormal_cellular_cholesterol2.16019700
15MP0001800_abnormal_humoral_immune2.15445890
16MP0009697_abnormal_copulation2.13822423
17MP0000685_abnormal_immune_system2.12351889
18MP0004808_abnormal_hematopoietic_stem2.11760321
19MP0000465_gastrointestinal_hemorrhage2.07493034
20MP0001790_abnormal_immune_system2.07126794
21MP0005387_immune_system_phenotype2.07126794
22MP0001853_heart_inflammation1.96076236
23MP0009785_altered_susceptibility_to1.94833590
24MP0005000_abnormal_immune_tolerance1.92603427
25MP0002452_abnormal_antigen_presenting1.89706374
26MP0010155_abnormal_intestine_physiology1.89007736
27MP0002723_abnormal_immune_serum1.88170006
28MP0002420_abnormal_adaptive_immunity1.84886982
29MP0001819_abnormal_immune_cell1.84296996
30MP0002148_abnormal_hypersensitivity_rea1.83558358
31MP0000681_abnormal_thyroid_gland1.82429202
32MP0005397_hematopoietic_system_phenotyp1.81992405
33MP0001545_abnormal_hematopoietic_system1.81992405
34MP0004510_myositis1.81429357
35MP0003828_pulmonary_edema1.80184001
36MP0004947_skin_inflammation1.79393064
37MP0005174_abnormal_tail_pigmentation1.77621726
38MP0005409_darkened_coat_color1.76345245
39MP0002398_abnormal_bone_marrow1.73855070
40MP0002396_abnormal_hematopoietic_system1.73585106
41MP0005375_adipose_tissue_phenotype1.72455393
42MP0009384_cardiac_valve_regurgitation1.71909292
43MP0002405_respiratory_system_inflammati1.68125425
44MP0004036_abnormal_muscle_relaxation1.64351501
45MP0003172_abnormal_lysosome_physiology1.62795080
46MP0003866_abnormal_defecation1.59981694
47MP0003436_decreased_susceptibility_to1.58799496
48MP0005464_abnormal_platelet_physiology1.58138231
49MP0005025_abnormal_response_to1.56556737
50MP0001849_ear_inflammation1.55655680
51MP0010234_abnormal_vibrissa_follicle1.50006797
52MP0002971_abnormal_brown_adipose1.49149670
53MP0003303_peritoneal_inflammation1.48926852
54MP0000716_abnormal_immune_system1.48766789
55MP0002419_abnormal_innate_immunity1.48483769
56MP0005075_abnormal_melanosome_morpholog1.47704436
57MP0001851_eye_inflammation1.46751103
58MP0000003_abnormal_adipose_tissue1.45091405
59MP0000703_abnormal_thymus_morphology1.42949268
60MP0005670_abnormal_white_adipose1.42555042
61MP0008007_abnormal_cellular_replicative1.42042715
62MP0000569_abnormal_digit_pigmentation1.34244996
63MP0003941_abnormal_skin_development1.33292178
64MP0003045_fibrosis1.32384219
65MP0009278_abnormal_bone_marrow1.31824549
66MP0004264_abnormal_extraembryonic_tissu1.30501629
67MP0002254_reproductive_system_inflammat1.29811610
68MP0002722_abnormal_immune_system1.28384298
69MP0000490_abnormal_crypts_of1.27986181
70MP0002998_abnormal_bone_remodeling1.27004787
71MP0001533_abnormal_skeleton_physiology1.24727586
72MP0003943_abnormal_hepatobiliary_system1.24699678
73MP0001879_abnormal_lymphatic_vessel1.23455222
74MP0005310_abnormal_salivary_gland1.20404785
75MP0002933_joint_inflammation1.20034738
76MP0002060_abnormal_skin_morphology1.19732495
77MP0003868_abnormal_feces_composition1.19214328
78MP0004185_abnormal_adipocyte_glucose1.18398517
79MP0004381_abnormal_hair_follicle1.17699021
80MP0004782_abnormal_surfactant_physiolog1.17434911
81MP0006054_spinal_hemorrhage1.16136573
82MP0006138_congestive_heart_failure1.15886858
83MP0000689_abnormal_spleen_morphology1.15862797
84MP0005535_abnormal_body_temperature1.15394635
85MP0002429_abnormal_blood_cell1.14706800
86MP0001845_abnormal_inflammatory_respons1.14375475
87MP0000383_abnormal_hair_follicle1.14288701
88MP0004147_increased_porphyrin_level1.12094909
89MP0008004_abnormal_stomach_pH1.12091590
90MP0008961_abnormal_basal_metabolism1.11942972
91MP0005666_abnormal_adipose_tissue1.11929623
92MP0004134_abnormal_chest_morphology1.11226536
93MP0010352_gastrointestinal_tract_polyps1.10479300
94MP0002277_abnormal_respiratory_mucosa1.09251329
95MP0004130_abnormal_muscle_cell1.07524882
96MP0001216_abnormal_epidermal_layer1.05792755
97MP0005360_urolithiasis1.04545339
98MP0005076_abnormal_cell_differentiation1.04426800
99MP0002138_abnormal_hepatobiliary_system1.03888534
100MP0001666_abnormal_nutrient_absorption1.03237033
101MP0009115_abnormal_fat_cell1.02779780
102MP0010678_abnormal_skin_adnexa1.01412058
103MP0002132_abnormal_respiratory_system1.00016147
104MP0009764_decreased_sensitivity_to0.98823351
105MP0000462_abnormal_digestive_system0.97248289
106MP0000015_abnormal_ear_pigmentation0.96482778
107MP0000627_abnormal_mammary_gland0.95080427
108MP0001664_abnormal_digestion0.94731285
109MP0009379_abnormal_foot_pigmentation0.94664382
110MP0003566_abnormal_cell_adhesion0.92553249
111MP0001881_abnormal_mammary_gland0.92427908
112MP0005646_abnormal_pituitary_gland0.91807241
113MP0006082_CNS_inflammation0.90228868
114MP0003453_abnormal_keratinocyte_physiol0.89155281
115MP0005084_abnormal_gallbladder_morpholo0.88566804
116MP0009840_abnormal_foam_cell0.88544682
117MP0003448_altered_tumor_morphology0.88315896
118MP0002095_abnormal_skin_pigmentation0.87531313
119MP0010630_abnormal_cardiac_muscle0.87354426
120MP0003252_abnormal_bile_duct0.86883002
121MP0006292_abnormal_olfactory_placode0.86604712
122MP0005220_abnormal_exocrine_pancreas0.85070386
123MP0005334_abnormal_fat_pad0.85056127
124MP0001663_abnormal_digestive_system0.84319702
125MP0002128_abnormal_blood_circulation0.84192032
126MP0001501_abnormal_sleep_pattern0.83706201
127MP0002127_abnormal_cardiovascular_syste0.83373404
128MP0000427_abnormal_hair_cycle0.82587255
129MP0001191_abnormal_skin_condition0.82537458
130MP0001188_hyperpigmentation0.82483062
131MP0002796_impaired_skin_barrier0.81157344
132MP0002139_abnormal_hepatobiliary_system0.80892475
133MP0002160_abnormal_reproductive_system0.80184065
134MP0000230_abnormal_systemic_arterial0.80100422
135MP0005275_abnormal_skin_tensile0.79637970
136MP0000858_altered_metastatic_potential0.77712556
137MP0004484_altered_response_of0.76408341
138MP0003656_abnormal_erythrocyte_physiolo0.75494041
139MP0001661_extended_life_span0.75475482
140MP0000249_abnormal_blood_vessel0.74508193
141MP0010368_abnormal_lymphatic_system0.73632256
142MP0009931_abnormal_skin_appearance0.73306550
143MP0005319_abnormal_enzyme/_coenzyme0.72804328
144MP0002098_abnormal_vibrissa_morphology0.72478678
145MP0000470_abnormal_stomach_morphology0.72112135
146MP0000733_abnormal_muscle_development0.71252644
147MP0002837_dystrophic_cardiac_calcinosis0.68575263
148MP0000598_abnormal_liver_morphology0.66972930
149MP0008775_abnormal_heart_ventricle0.66962290
150MP0001784_abnormal_fluid_regulation0.65625355
151MP0002086_abnormal_extraembryonic_tissu0.64941335
152MP0003806_abnormal_nucleotide_metabolis0.63802401
153MP0009250_abnormal_appendicular_skeleto0.63336683
154MP0004087_abnormal_muscle_fiber0.63055283
155MP0005023_abnormal_wound_healing0.63020790
156MP0010329_abnormal_lipoprotein_level0.62797927
157MP0001915_intracranial_hemorrhage0.61747467

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)5.23895385
2Optic neuritis (HP:0100653)5.23895385
3Myositis (HP:0100614)5.14579049
4Orchitis (HP:0100796)4.91787851
5Papillary thyroid carcinoma (HP:0002895)4.24555263
6Keratoconjunctivitis sicca (HP:0001097)4.08026923
7Abnormality of the fingertips (HP:0001211)4.04534941
8Keratoconjunctivitis (HP:0001096)3.61948591
9Ankyloglossia (HP:0010296)3.58881208
10Lip pit (HP:0100267)3.46835014
11J-shaped sella turcica (HP:0002680)3.38674258
12IgM deficiency (HP:0002850)3.38179067
13Thyroiditis (HP:0100646)3.35030482
14Gingival bleeding (HP:0000225)3.34719509
15Acute lymphatic leukemia (HP:0006721)3.29890070
16Arterial thrombosis (HP:0004420)3.26378929
17Cervical subluxation (HP:0003308)3.23398105
18Abnormality of the prostate (HP:0008775)3.15135510
19Prostate neoplasm (HP:0100787)3.10398030
20Elevated erythrocyte sedimentation rate (HP:0003565)3.06548076
21Right ventricular cardiomyopathy (HP:0011663)3.05641109
22Pulmonary infiltrates (HP:0002113)2.97288400
23Rhabdomyolysis (HP:0003201)2.96442429
24T lymphocytopenia (HP:0005403)2.96378270
25Thyroid carcinoma (HP:0002890)2.92936951
26Acute myeloid leukemia (HP:0004808)2.91808488
27Abnormality of T cell number (HP:0011839)2.91273094
28Dyschromatopsia (HP:0007641)2.90626669
29Prolonged bleeding time (HP:0003010)2.89217549
30Exercise-induced myalgia (HP:0003738)2.88728844
31Cone-rod dystrophy (HP:0000548)2.88038073
32Thrombocytosis (HP:0001894)2.85175654
33Autoimmune thrombocytopenia (HP:0001973)2.82219477
34B lymphocytopenia (HP:0010976)2.81668096
35Abnormality of B cell number (HP:0010975)2.81668096
36Metaphyseal dysplasia (HP:0100255)2.79567585
37Increased mean platelet volume (HP:0011877)2.78124167
38Abnormality of the intrinsic pathway (HP:0010989)2.73132576
39Recurrent viral infections (HP:0004429)2.73104395
40Recurrent fungal infections (HP:0002841)2.72814818
41Distal arthrogryposis (HP:0005684)2.71442583
42Abnormality of the nasal septum (HP:0000419)2.70755526
43Persistence of primary teeth (HP:0006335)2.68502643
44Pigmentary retinal degeneration (HP:0001146)2.68004236
45Flat acetabular roof (HP:0003180)2.67509433
46Vasculitis (HP:0002633)2.67025854
47Panhypogammaglobulinemia (HP:0003139)2.61961822
48Autoimmune hemolytic anemia (HP:0001890)2.61751178
49Subaortic stenosis (HP:0001682)2.56519134
50Abnormality of the left ventricular outflow tract (HP:0011103)2.56519134
51Abnormality of oral frenula (HP:0000190)2.54396353
52Increased density of long bones (HP:0006392)2.54162994
53Severe combined immunodeficiency (HP:0004430)2.52752476
54Chronic otitis media (HP:0000389)2.50471026
55Hematochezia (HP:0002573)2.49326266
56Central scotoma (HP:0000603)2.49075937
57Hemoptysis (HP:0002105)2.47326543
58Eczematoid dermatitis (HP:0000976)2.47141238
59Deformed sella turcica (HP:0002681)2.45988239
60IgA deficiency (HP:0002720)2.44495999
61Myoglobinuria (HP:0002913)2.43462265
62Menorrhagia (HP:0000132)2.42728742
63Aortic aneurysm (HP:0004942)2.41565873
64Flared iliac wings (HP:0002869)2.41358785
65Pustule (HP:0200039)2.40856707
66Broad face (HP:0000283)2.40770373
67Abnormality of eosinophils (HP:0001879)2.40735509
68Recurrent bronchitis (HP:0002837)2.37403171
69Curly hair (HP:0002212)2.36243278
70Volvulus (HP:0002580)2.35749442
71Muscle fiber inclusion bodies (HP:0100299)2.32117272
72Viral hepatitis (HP:0006562)2.30645216
73Meningitis (HP:0001287)2.30130663
74Nemaline bodies (HP:0003798)2.29009165
75Chronic diarrhea (HP:0002028)2.27996439
76Menstrual irregularities (HP:0000858)2.27369180
77Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.26906068
78Heterotopia (HP:0002282)2.25541751
79Eosinophilia (HP:0001880)2.24169226
80Spinal cord lesions (HP:0100561)2.24134867
81Syringomyelia (HP:0003396)2.24134867
82IgG deficiency (HP:0004315)2.22306454
83Hyperkalemia (HP:0002153)2.20497820
84Onycholysis (HP:0001806)2.19293838
85Glomerulopathy (HP:0100820)2.14359204
86Mucopolysacchariduria (HP:0008155)2.13403059
87Urinary glycosaminoglycan excretion (HP:0003541)2.13403059
88Thickened calvaria (HP:0002684)2.13398214
89Truncal obesity (HP:0001956)2.12300687
90Absent frontal sinuses (HP:0002688)2.10760314
91Abnormality of T cells (HP:0002843)2.10303446
92Encephalitis (HP:0002383)2.09212465
93Coarse hair (HP:0002208)2.07874869
94Abnormality of the sella turcica (HP:0002679)2.06478845
95Gangrene (HP:0100758)2.06220891
96Periodontitis (HP:0000704)2.02530580
97Palmar hyperkeratosis (HP:0010765)2.02530170
98Amniotic constriction ring (HP:0009775)2.01095523
99Abnormality of placental membranes (HP:0011409)2.01095523
100Abnormality of nail color (HP:0100643)2.00931839
101Xerostomia (HP:0000217)2.00847608
102Leukocytosis (HP:0001974)2.00557092
103Combined immunodeficiency (HP:0005387)2.00035220
104Plantar hyperkeratosis (HP:0007556)2.00016438
105Interstitial pulmonary disease (HP:0006530)1.99625792
106Keratitis (HP:0000491)1.99595145
107Abnormality of the wing of the ilium (HP:0011867)1.98376042
108Popliteal pterygium (HP:0009756)1.97769385
109Thoracolumbar scoliosis (HP:0002944)1.97522550
110Epistaxis (HP:0000421)1.96308077
111Wide nose (HP:0000445)1.93731801
112Abnormal delayed hypersensitivity skin test (HP:0002963)1.92888681
113Spondylolisthesis (HP:0003302)1.92116457
114Mediastinal lymphadenopathy (HP:0100721)1.92036790
115Pulmonary embolism (HP:0002204)1.91572343
116Ureteral stenosis (HP:0000071)1.90593869
117Abnormality of the pleura (HP:0002103)1.89955488
118Premature loss of primary teeth (HP:0006323)1.88549284
119Palmoplantar hyperkeratosis (HP:0000972)1.87523702
120Depressed nasal tip (HP:0000437)1.87247090
121Hypoproteinemia (HP:0003075)1.86327095
122Oligodontia (HP:0000677)1.84216024
123Abnormal biliary tract morphology (HP:0012440)1.83705294
124Abnormality of the pericardium (HP:0001697)1.82595278
125Inflammation of the large intestine (HP:0002037)1.82553633
126Chest pain (HP:0100749)1.82179467
127Hypoplasia of the thymus (HP:0000778)1.81928245
128Ureteral obstruction (HP:0006000)1.81669899
129Renal cortical cysts (HP:0000803)1.81549827
130Increased IgE level (HP:0003212)1.80285644
131Deep philtrum (HP:0002002)1.80132367
132Impaired platelet aggregation (HP:0003540)1.79437413
133Abnormal platelet function (HP:0011869)1.79437413
134Agammaglobulinemia (HP:0004432)1.79223630
135Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.78919546
136Urethral obstruction (HP:0000796)1.78217479
137Chronic mucocutaneous candidiasis (HP:0002728)1.77399688
138Recurrent cutaneous fungal infections (HP:0011370)1.77399688
139Asymmetry of the thorax (HP:0001555)1.77033088
140Acanthocytosis (HP:0001927)1.76752449
141Abnormality of macular pigmentation (HP:0008002)1.76242402
142Narrow palate (HP:0000189)1.76189248
143Granulocytopenia (HP:0001913)1.75583379
144Lymphopenia (HP:0001888)1.74594997
145Abnormality of polysaccharide metabolism (HP:0011012)1.74529153
146Abnormality of glycosaminoglycan metabolism (HP:0004371)1.74529153
147Abnormality of mucopolysaccharide metabolism (HP:0011020)1.74529153
148Abnormality of male internal genitalia (HP:0000022)1.73606993
149Arterial tortuosity (HP:0005116)1.73102255
150Recurrent bacterial skin infections (HP:0005406)1.72623927
151Aortic dissection (HP:0002647)1.71325114
152Subacute progressive viral hepatitis (HP:0006572)1.70784010
153Ectropion (HP:0000656)1.70333724
154Scapular winging (HP:0003691)1.70269610
155Fatigue (HP:0012378)1.70151970
156Dysostosis multiplex (HP:0000943)1.69398484
157Abnormal platelet volume (HP:0011876)1.69266326
158Reduced antithrombin III activity (HP:0001976)1.69215986
159Milia (HP:0001056)1.68372649
160Scanning speech (HP:0002168)1.68267743
161Gastrointestinal inflammation (HP:0004386)1.67713342
162Cystic hygroma (HP:0000476)1.67621918
163Macroorchidism (HP:0000053)1.67396934
164Aplasia cutis congenita (HP:0001057)1.67082245
165Abnormal hair whorl (HP:0010721)1.66907244
166Cranial hyperostosis (HP:0004437)1.66624294
167Decreased central vision (HP:0007663)1.66037741
168Biliary tract neoplasm (HP:0100574)1.65966725
169Facial hemangioma (HP:0000329)1.65913107
170Stomach cancer (HP:0012126)1.65437074
171Abnormality of the common coagulation pathway (HP:0010990)1.63838108
172Spinal canal stenosis (HP:0003416)1.63199229
173Sandal gap (HP:0001852)1.62543064
174Neonatal respiratory distress (HP:0002643)1.62312523
175Fragile skin (HP:0001030)1.61133101
176Spontaneous abortion (HP:0005268)1.60320898
177Thick eyebrow (HP:0000574)1.60226266

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.32879890
2SCYL23.65369325
3TGFBR22.73054605
4MAP4K12.67476882
5OBSCN2.63609457
6AKT32.42668102
7FGFR32.39216476
8MAP3K142.21538626
9PIK3CG2.15766669
10RIPK42.11321018
11LATS12.10690486
12SIK32.07001879
13TEC2.05035336
14TAOK32.03502295
15JAK31.99915401
16MAPK151.99098153
17FLT31.97349782
18BRD41.92339333
19CAMK1D1.88088027
20TBK11.82347072
21IKBKE1.80176029
22JAK11.72932983
23EPHA31.72851856
24MAP2K31.69741280
25CAMK1G1.66768820
26ZAP701.58260818
27SIK21.57858015
28EIF2AK31.55512616
29TYK21.53645288
30CHUK1.53557265
31BRSK21.45607816
32PINK11.45457120
33CLK11.43808937
34MAP3K61.41063104
35IKBKB1.40496790
36FRK1.38361703
37IRAK31.38171712
38ACVR1B1.37216197
39PBK1.35488148
40KIT1.33208678
41MAPK71.31346207
42STK391.30480038
43ITK1.27722254
44NUAK11.24382304
45MST41.22794948
46NLK1.22237654
47SIK11.22131154
48BTK1.17304869
49STK101.16775817
50CDK91.14121294
51PDGFRA1.11384640
52CDK61.11097137
53LCK1.09417105
54IRAK11.06958907
55PIK3CA1.01810285
56RIPK11.00597322
57MAP2K60.99462695
58FGFR40.96446567
59HIPK20.94425598
60HCK0.93731069
61TGFBR10.93381685
62PDGFRB0.92850826
63TIE10.92776226
64EPHB10.91258317
65* SYK0.90409517
66PIM10.85880014
67JAK20.84694467
68TRPM70.82094352
69CSF1R0.81799717
70CDK30.81641577
71BMPR20.80028843
72MAP3K120.79602833
73MATK0.79115148
74GRK70.78625695
75IRAK40.78381642
76MET0.77556663
77YES10.74355727
78MKNK20.73164192
79RPS6KA40.71132480
80STK30.70898618
81EEF2K0.70670068
82PRKG20.70564097
83NEK90.70387427
84DMPK0.70062948
85GRK60.69573156
86STK240.69502368
87BMPR1B0.68210681
88CASK0.67933926
89TNIK0.67323646
90ERBB30.67281402
91TNK20.66722887
92MST1R0.64989829
93MAPK100.64159579
94SGK20.63920740
95MAP2K40.63653572
96MAP3K10.63618739
97SGK30.62603954
98STK38L0.61185981
99WNK10.59746381
100FER0.59589587
101NEK60.58946313
102AKT20.58427489
103TTN0.57995470
104CAMKK20.57732000
105BCKDK0.57725907
106RPS6KB10.57263558
107MKNK10.56546213
108PRKCQ0.55921337
109MAP2K10.55643866
110MTOR0.54675113
111MAPK30.54463672
112RPS6KC10.54087652
113RPS6KL10.54087652
114MAP3K70.53367170
115CDK70.53115755
116MAP3K20.53080299
117RET0.52758653
118IGF1R0.52652558
119TAF10.52094031
120FES0.52043614
121IRAK20.51398826
122MAPKAPK50.51364552
123CDK120.50895005
124PAK20.50804954
125MARK30.49422344
126EIF2AK20.48548359
127MAPK120.48537924
128PRKAA20.48458372
129PTK60.48356251
130FGFR20.48266119
131CDK80.47216938
132MAP3K130.46718527
133ATM0.46219374
134LYN0.45379765
135CAMK10.45151519
136RPS6KB20.44718598
137RPS6KA50.43969310
138VRK10.43601666
139RPS6KA60.43467623
140CAMK40.43258678
141TSSK60.41505320
142ABL10.36277086

Predicted pathways (KEGG)

RankGene SetZ-score
1Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.78727867
2Osteoclast differentiation_Homo sapiens_hsa043802.13289671
3Primary immunodeficiency_Homo sapiens_hsa053402.09052690
4T cell receptor signaling pathway_Homo sapiens_hsa046602.05999991
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.04616855
6Leishmaniasis_Homo sapiens_hsa051401.96055592
7NF-kappa B signaling pathway_Homo sapiens_hsa040641.81851773
8Jak-STAT signaling pathway_Homo sapiens_hsa046301.72024182
9Hematopoietic cell lineage_Homo sapiens_hsa046401.69711146
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.65631632
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.64845331
12B cell receptor signaling pathway_Homo sapiens_hsa046621.64169485
13Measles_Homo sapiens_hsa051621.63022863
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.59384312
15Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.57024413
16Toxoplasmosis_Homo sapiens_hsa051451.55610993
17Autoimmune thyroid disease_Homo sapiens_hsa053201.51395505
18Allograft rejection_Homo sapiens_hsa053301.50753791
19Platelet activation_Homo sapiens_hsa046111.47162156
20TNF signaling pathway_Homo sapiens_hsa046681.44205573
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38886618
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.37602180
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.36684875
24Inositol phosphate metabolism_Homo sapiens_hsa005621.33402345
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33063948
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.30706903
27Transcriptional misregulation in cancer_Homo sapiens_hsa052021.30217068
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28049174
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28003823
30Acute myeloid leukemia_Homo sapiens_hsa052211.26288788
31mTOR signaling pathway_Homo sapiens_hsa041501.26154780
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.25944136
33Hepatitis B_Homo sapiens_hsa051611.24826264
34Chronic myeloid leukemia_Homo sapiens_hsa052201.18455869
35Pancreatic secretion_Homo sapiens_hsa049721.17538222
36Prolactin signaling pathway_Homo sapiens_hsa049171.17083923
37Pertussis_Homo sapiens_hsa051331.14823556
38Renin secretion_Homo sapiens_hsa049241.13708915
39Amoebiasis_Homo sapiens_hsa051461.13699131
40Other glycan degradation_Homo sapiens_hsa005111.12423954
41Influenza A_Homo sapiens_hsa051641.09751252
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.09415018
43Circadian rhythm_Homo sapiens_hsa047101.09326265
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09036960
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04545502
46Chemokine signaling pathway_Homo sapiens_hsa040621.04332881
47Vitamin digestion and absorption_Homo sapiens_hsa049771.03719546
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.03628630
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03443322
50Leukocyte transendothelial migration_Homo sapiens_hsa046701.01487860
51Glycerophospholipid metabolism_Homo sapiens_hsa005641.00505596
52Asthma_Homo sapiens_hsa053100.98966618
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98452842
54Long-term depression_Homo sapiens_hsa047300.98207028
55African trypanosomiasis_Homo sapiens_hsa051430.97722577
56Herpes simplex infection_Homo sapiens_hsa051680.96565232
57Small cell lung cancer_Homo sapiens_hsa052220.95874963
58Malaria_Homo sapiens_hsa051440.95122256
59Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.95039881
60Ovarian steroidogenesis_Homo sapiens_hsa049130.94956068
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.94561711
62Antigen processing and presentation_Homo sapiens_hsa046120.93900600
63Phototransduction_Homo sapiens_hsa047440.92181880
64Pancreatic cancer_Homo sapiens_hsa052120.89074109
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87128419
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86225341
67Systemic lupus erythematosus_Homo sapiens_hsa053220.86179593
68Tuberculosis_Homo sapiens_hsa051520.84826311
69Glycerolipid metabolism_Homo sapiens_hsa005610.84237692
70Colorectal cancer_Homo sapiens_hsa052100.83893767
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83511031
72Renin-angiotensin system_Homo sapiens_hsa046140.83417542
73Retinol metabolism_Homo sapiens_hsa008300.83342658
74Hepatitis C_Homo sapiens_hsa051600.83264628
75HTLV-I infection_Homo sapiens_hsa051660.81310467
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80686713
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.79673725
78MAPK signaling pathway_Homo sapiens_hsa040100.79623657
79Fat digestion and absorption_Homo sapiens_hsa049750.79508916
80Viral myocarditis_Homo sapiens_hsa054160.79116741
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78959708
82Salmonella infection_Homo sapiens_hsa051320.78796328
83Adherens junction_Homo sapiens_hsa045200.77102062
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76959257
85Pentose phosphate pathway_Homo sapiens_hsa000300.76710233
86Shigellosis_Homo sapiens_hsa051310.76604613
87FoxO signaling pathway_Homo sapiens_hsa040680.75119270
88Focal adhesion_Homo sapiens_hsa045100.74073271
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73955110
90Apoptosis_Homo sapiens_hsa042100.73606931
91Proteoglycans in cancer_Homo sapiens_hsa052050.73453065
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73247111
93Staphylococcus aureus infection_Homo sapiens_hsa051500.72194975
94VEGF signaling pathway_Homo sapiens_hsa043700.71444643
95Dilated cardiomyopathy_Homo sapiens_hsa054140.71292415
96Glucagon signaling pathway_Homo sapiens_hsa049220.70843174
97Prostate cancer_Homo sapiens_hsa052150.70842248
98Salivary secretion_Homo sapiens_hsa049700.70738626
99Fatty acid degradation_Homo sapiens_hsa000710.70717509
100MicroRNAs in cancer_Homo sapiens_hsa052060.70189683
101cAMP signaling pathway_Homo sapiens_hsa040240.70163218
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70133888
103ErbB signaling pathway_Homo sapiens_hsa040120.70052765
104Rheumatoid arthritis_Homo sapiens_hsa053230.69269456
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67854860
106Lysosome_Homo sapiens_hsa041420.66478003
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.66045376
108ECM-receptor interaction_Homo sapiens_hsa045120.65654120
109Pathways in cancer_Homo sapiens_hsa052000.65408897
110Insulin resistance_Homo sapiens_hsa049310.65303751
111Long-term potentiation_Homo sapiens_hsa047200.64480649
112Arachidonic acid metabolism_Homo sapiens_hsa005900.64021709
113Legionellosis_Homo sapiens_hsa051340.63005218
114Insulin signaling pathway_Homo sapiens_hsa049100.62193903
115Graft-versus-host disease_Homo sapiens_hsa053320.61964338
116Rap1 signaling pathway_Homo sapiens_hsa040150.61569899
117Non-small cell lung cancer_Homo sapiens_hsa052230.61382379
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.61336692
119Protein digestion and absorption_Homo sapiens_hsa049740.60195996
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59412415
121HIF-1 signaling pathway_Homo sapiens_hsa040660.59385454
122Olfactory transduction_Homo sapiens_hsa047400.58072083
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57829239
124Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57665237
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57201776
126GnRH signaling pathway_Homo sapiens_hsa049120.57044431
127Choline metabolism in cancer_Homo sapiens_hsa052310.56951817
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56785264
129Glioma_Homo sapiens_hsa052140.56643169
130Gap junction_Homo sapiens_hsa045400.56319931
131PPAR signaling pathway_Homo sapiens_hsa033200.56037524
132Endometrial cancer_Homo sapiens_hsa052130.55903805
133Oxytocin signaling pathway_Homo sapiens_hsa049210.55828083
134Sphingolipid metabolism_Homo sapiens_hsa006000.55113647
135Dorso-ventral axis formation_Homo sapiens_hsa043200.55000047
136Fatty acid biosynthesis_Homo sapiens_hsa000610.54083785
137Mineral absorption_Homo sapiens_hsa049780.54034863
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53341971
139Renal cell carcinoma_Homo sapiens_hsa052110.53091988
140Starch and sucrose metabolism_Homo sapiens_hsa005000.52337744
141Caffeine metabolism_Homo sapiens_hsa002320.52078621
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51872657
143Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51462710
144Wnt signaling pathway_Homo sapiens_hsa043100.51019642
145Melanoma_Homo sapiens_hsa052180.50835362
146Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50803626
147Type II diabetes mellitus_Homo sapiens_hsa049300.50738192
148Thyroid cancer_Homo sapiens_hsa052160.49847909

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