NRP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)5.26889565
2* vascular endothelial growth factor signaling pathway (GO:0038084)5.00663801
3glomerular visceral epithelial cell development (GO:0072015)4.99077885
4endothelium development (GO:0003158)4.65376774
5glomerular epithelial cell development (GO:0072310)4.37174372
6glomerular basement membrane development (GO:0032836)4.31677318
7surfactant homeostasis (GO:0043129)4.29216698
8skin morphogenesis (GO:0043589)4.23977501
9barbed-end actin filament capping (GO:0051016)4.13497382
10lymphangiogenesis (GO:0001946)3.85353653
11* retina vasculature morphogenesis in camera-type eye (GO:0061299)3.78387106
12* substrate-dependent cell migration (GO:0006929)3.74711755
13cell adhesion mediated by integrin (GO:0033627)3.68950762
14chemical homeostasis within a tissue (GO:0048875)3.65522663
15chondrocyte proliferation (GO:0035988)3.65201139
16* cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.60186228
17glomerular filtration (GO:0003094)3.48613809
18renal filtration (GO:0097205)3.47795332
19regulation of endothelial cell differentiation (GO:0045601)3.45544714
20basement membrane organization (GO:0071711)3.38104894
21type B pancreatic cell proliferation (GO:0044342)3.25700124
22cellular response to vitamin (GO:0071295)3.24975284
23positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.19825121
24regulation of integrin-mediated signaling pathway (GO:2001044)3.19793362
25endothelial cell morphogenesis (GO:0001886)3.19656085
26low-density lipoprotein particle clearance (GO:0034383)3.19547420
27sequestering of extracellular ligand from receptor (GO:0035581)3.15805842
28collagen metabolic process (GO:0032963)3.15300676
29blood vessel maturation (GO:0001955)3.14702301
30cellular response to vitamin D (GO:0071305)3.12938593
31adhesion of symbiont to host cell (GO:0044650)3.10663622
32virion attachment to host cell (GO:0019062)3.10663622
33protein heterotrimerization (GO:0070208)3.07405725
34negative regulation of nitric-oxide synthase activity (GO:0051001)3.04783431
35keratan sulfate catabolic process (GO:0042340)3.04505392
36apoptotic cell clearance (GO:0043277)3.04054626
37regulation of sequestering of triglyceride (GO:0010889)3.03495553
38mesodermal cell differentiation (GO:0048333)3.03466961
39collagen catabolic process (GO:0030574)3.01687752
40fatty acid transmembrane transport (GO:1902001)3.01382336
41regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.01284449
42* vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.99638023
43positive regulation of vasculogenesis (GO:2001214)2.96597488
44glomerulus development (GO:0032835)2.95844523
45mesenchymal-epithelial cell signaling (GO:0060638)2.95428162
46regulation of cholesterol storage (GO:0010885)2.93419308
47multicellular organismal macromolecule metabolic process (GO:0044259)2.91174478
48plasma membrane repair (GO:0001778)2.90616955
49regulation of mononuclear cell migration (GO:0071675)2.90011713
50* patterning of blood vessels (GO:0001569)2.89989495
51* cell migration involved in sprouting angiogenesis (GO:0002042)2.87551624
52kidney mesenchyme development (GO:0072074)2.82978169
53negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.82925866
54membrane raft organization (GO:0031579)2.82844712
55negative regulation of anoikis (GO:2000811)2.82838572
56Golgi transport vesicle coating (GO:0048200)2.82477056
57COPI coating of Golgi vesicle (GO:0048205)2.82477056
58regulation of vasculogenesis (GO:2001212)2.82408804
59negative regulation of fibrinolysis (GO:0051918)2.81931637
60venous blood vessel morphogenesis (GO:0048845)2.81639035
61wound healing, spreading of cells (GO:0044319)2.79368697
62transcytosis (GO:0045056)2.78758643
63adhesion of symbiont to host (GO:0044406)2.78450915
64hemidesmosome assembly (GO:0031581)2.77907543
65substrate adhesion-dependent cell spreading (GO:0034446)2.77647762
66extracellular matrix disassembly (GO:0022617)2.76865939
67multicellular organismal metabolic process (GO:0044236)2.76753795
68muscle cell migration (GO:0014812)2.74752836
69regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.74735566
70multicellular organismal catabolic process (GO:0044243)2.73510471
71metanephric mesenchyme development (GO:0072075)2.72584882
72epithelial cell-cell adhesion (GO:0090136)2.72152574
73heart trabecula formation (GO:0060347)2.72005947
74Notch signaling involved in heart development (GO:0061314)2.70924651
75blood vessel remodeling (GO:0001974)2.70329638
76extracellular fibril organization (GO:0043206)2.69218641
77regulation of chemokine-mediated signaling pathway (GO:0070099)2.68831232
78hyaluronan catabolic process (GO:0030214)2.67925905
79positive regulation of blood vessel endothelial cell migration (GO:0043536)2.67366391
80complement activation, alternative pathway (GO:0006957)2.67125181
81negative regulation of smooth muscle cell migration (GO:0014912)2.66621019
82regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.65716203
83positive regulation of p38MAPK cascade (GO:1900745)2.63993528
84positive regulation of fatty acid beta-oxidation (GO:0032000)2.63862165
85cardiac myofibril assembly (GO:0055003)2.63850852
86stress fiber assembly (GO:0043149)2.63570202
87* blood vessel endothelial cell migration (GO:0043534)2.63383783
88extracellular regulation of signal transduction (GO:1900115)2.62211307
89extracellular negative regulation of signal transduction (GO:1900116)2.62211307
90wound healing, spreading of epidermal cells (GO:0035313)2.59946573
91positive regulation of fatty acid oxidation (GO:0046321)2.59944111
92regulation of membrane protein ectodomain proteolysis (GO:0051043)2.59125278
93negative regulation of adherens junction organization (GO:1903392)2.58094548
94negative regulation of focal adhesion assembly (GO:0051895)2.58094548
95negative regulation of cell junction assembly (GO:1901889)2.58094548
96* axon extension involved in axon guidance (GO:0048846)2.58043424
97* neuron projection extension involved in neuron projection guidance (GO:1902284)2.58043424
98protein hydroxylation (GO:0018126)2.57845774
99heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.57443756
100iron ion import (GO:0097286)2.57098160
101positive regulation of receptor recycling (GO:0001921)2.56057666
102negative regulation of chondrocyte differentiation (GO:0032331)2.55226971
103negative regulation of endothelial cell proliferation (GO:0001937)2.54411297
104extracellular matrix assembly (GO:0085029)2.54385809
105hypotonic response (GO:0006971)2.54295896
106* sprouting angiogenesis (GO:0002040)2.53555468
107negative regulation of nitric oxide biosynthetic process (GO:0045019)2.53390166
108positive regulation of endothelial cell apoptotic process (GO:2000353)2.53231323
109positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.52768956
110phagocytosis, recognition (GO:0006910)2.52089963
111glial cell migration (GO:0008347)2.51952823
112protein carboxylation (GO:0018214)2.51580794
113peptidyl-glutamic acid carboxylation (GO:0017187)2.51580794
114epithelial cell differentiation involved in kidney development (GO:0035850)2.50778889
115endothelial cell proliferation (GO:0001935)2.50304708
116regulation of fibrinolysis (GO:0051917)2.50124808
117cell-substrate junction assembly (GO:0007044)2.50053454
118regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.49157590
119fibril organization (GO:0097435)2.48050178
120positive regulation of hemostasis (GO:1900048)2.46940199
121positive regulation of blood coagulation (GO:0030194)2.46940199
122negative regulation of Rho protein signal transduction (GO:0035024)2.46422860
123cGMP-mediated signaling (GO:0019934)2.45282995
124lung vasculature development (GO:0060426)2.45061158
125* dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.44766701
126extracellular matrix organization (GO:0030198)2.43887335
127negative regulation of blood vessel endothelial cell migration (GO:0043537)2.43620842
128response to magnesium ion (GO:0032026)2.43130588
129positive regulation of cell junction assembly (GO:1901890)2.43000616
130positive regulation of focal adhesion assembly (GO:0051894)2.43000616
131extracellular structure organization (GO:0043062)2.42854538
132morphogenesis of an endothelium (GO:0003159)2.42677482
133endothelial tube morphogenesis (GO:0061154)2.42677482
134negative regulation of platelet activation (GO:0010544)2.42662169
135* positive regulation of epithelial cell migration (GO:0010634)2.42350315
136regulation of protein activation cascade (GO:2000257)2.42169884
137positive regulation of extracellular matrix organization (GO:1903055)2.42143758
138regulation of tight junction assembly (GO:2000810)2.42096572
139positive regulation of endothelial cell differentiation (GO:0045603)2.41532522
140ovulation from ovarian follicle (GO:0001542)2.41263717
141regulation of complement activation (GO:0030449)2.40611191
142cell migration involved in heart development (GO:0060973)2.37582718
143endothelial cell differentiation (GO:0045446)2.37301036
144positive regulation of adherens junction organization (GO:1903393)2.36066291
145plasma lipoprotein particle clearance (GO:0034381)2.35905215
146negative regulation of blood coagulation (GO:0030195)2.35643570
147negative regulation of hemostasis (GO:1900047)2.35643570
148negative regulation of endothelial cell migration (GO:0010596)2.35464575
149negative regulation of endothelial cell apoptotic process (GO:2000352)2.33547065
150regulation of p38MAPK cascade (GO:1900744)2.33392631
151response to fluid shear stress (GO:0034405)2.31789862
152triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.31221337
153fibrinolysis (GO:0042730)2.31202142
154smooth muscle tissue development (GO:0048745)2.30913902
155vasculogenesis (GO:0001570)2.28093876
156carnitine shuttle (GO:0006853)2.27987355
157negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.27813866
158regulation of endothelial cell apoptotic process (GO:2000351)2.27728668
159positive regulation of macrophage cytokine production (GO:0060907)2.27464645
160* endothelial cell migration (GO:0043542)2.26269760
161positive regulation of coagulation (GO:0050820)2.25355757
162positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.24771564
163insulin-like growth factor receptor signaling pathway (GO:0048009)2.22746692
164collagen fibril organization (GO:0030199)2.22183322
165regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.21784405
166endodermal cell differentiation (GO:0035987)2.20901874
167regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.20613338
168alpha-linolenic acid metabolic process (GO:0036109)2.20427179
169negative regulation of coagulation (GO:0050819)2.20247200
170positive regulation of lipid storage (GO:0010884)2.18876217
171* blood vessel morphogenesis (GO:0048514)2.17978866

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.88211939
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.54983855
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.97105759
4CLOCK_20551151_ChIP-Seq_293T_Human2.77383463
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.54934538
6* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.34659855
7LXR_22158963_ChIP-Seq_LIVER_Mouse2.26199051
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.23212586
9* EP300_21415370_ChIP-Seq_HL-1_Mouse2.23085384
10GATA2_21666600_ChIP-Seq_HMVEC_Human2.22117008
11ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.21508798
12* RXR_22158963_ChIP-Seq_LIVER_Mouse2.18909051
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.12125402
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.07034221
15* WT1_19549856_ChIP-ChIP_CCG9911_Human1.99354611
16* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.91057960
17JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.89504170
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.83289114
19* CJUN_26792858_Chip-Seq_BT549_Human1.81576368
20* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.80202821
21GATA1_22025678_ChIP-Seq_K562_Human1.74777878
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.68016312
23* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67227347
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.62938857
25* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.62511005
26* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61630957
27* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.61028701
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60495990
29NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.59933788
30NRF2_20460467_ChIP-Seq_MEFs_Mouse1.59933788
31TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58995907
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.56219954
33SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.56107526
34ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.55642442
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55569992
36* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.53918885
37* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.52651799
38NFIB_24661679_ChIP-Seq_LUNG_Mouse1.50501279
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49417741
40* FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.48139334
41* EED_16625203_ChIP-ChIP_MESCs_Mouse1.45880679
42* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.45126082
43* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.43846520
44* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42908350
45* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42908350
46* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41327610
47* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40512800
48* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.40230044
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39513017
50* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37707230
51* TP53_18474530_ChIP-ChIP_U2OS_Human1.37550923
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.36364924
53* TBX20_22080862_ChIP-Seq_HEART_Mouse1.36129569
54* TBX20_22328084_ChIP-Seq_HEART_Mouse1.36129569
55* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.35163450
56STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.32253769
57* UBF1/2_26484160_Chip-Seq_HMECs_Human1.32140270
58SALL4_18804426_ChIP-ChIP_XEN_Mouse1.31449998
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30931670
60* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28883622
61BCAT_22108803_ChIP-Seq_LS180_Human1.28724652
62* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.27471270
63* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27456661
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26684716
65CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.26621838
66TP63_17297297_ChIP-ChIP_HaCaT_Human1.24237513
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23736377
68FOXO3_23340844_ChIP-Seq_DLD1_Human1.22583774
69* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21342318
70VDR_24787735_ChIP-Seq_THP-1_Human1.20556499
71* AHR_22903824_ChIP-Seq_MCF-7_Human1.20266183
72* GBX2_23144817_ChIP-Seq_PC3_Human1.19742612
73TP53_16413492_ChIP-PET_HCT116_Human1.19475148
74SOX2_20726797_ChIP-Seq_SW620_Human1.19183946
75* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.18054638
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.16812260
77* BRD4_25478319_ChIP-Seq_HGPS_Human1.13708314
78* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12378519
79CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12001622
80WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08898953
81* FOXA2_19822575_ChIP-Seq_HepG2_Human1.06913150
82CDX2_20551321_ChIP-Seq_CACO-2_Human1.05185970
83* ARNT_22903824_ChIP-Seq_MCF-7_Human1.05131934
84NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03136571
85SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03061379
86WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02992446
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02788187
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02684536
89TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02668420
90HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02644053
91* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.02348691
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01676043
93* TP53_23651856_ChIP-Seq_MEFs_Mouse1.01626383
94* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01214151
95* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00783778
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99895755
97* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99667457
98* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99410358
99EZH2_22144423_ChIP-Seq_EOC_Human0.99184810
100PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98390836
101* SA1_22415368_ChIP-Seq_MEFs_Mouse0.98371712
102NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98271696
103SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98031657
104NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97808927
105TP53_22127205_ChIP-Seq_IMR90_Human0.97216975
106* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97185882
107* IRF8_27001747_Chip-Seq_BMDM_Mouse0.96826752
108RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96365109
109TCF4_18268006_ChIP-ChIP_LS174T_Human0.96290771
110* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95757532
111HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94277729
112JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94276601
113CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94269011
114RXR_22108803_ChIP-Seq_LS180_Human0.93780024
115* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92953799
116* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92581487
117* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92491603
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.91650721
119RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91577584
120TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91477855
121* ELK3_25401928_ChIP-Seq_HUVEC_Human0.90893645
122SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90845947
123SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90845947
124EGR1_23403033_ChIP-Seq_LIVER_Mouse0.90618360
125* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90574914
126* JARID2_20064375_ChIP-Seq_MESCs_Mouse0.89870139
127* SMAD4_21741376_ChIP-Seq_HESCs_Human0.89291215
128* TP63_23658742_ChIP-Seq_EP156T_Human0.88572949
129TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88112630
130MYB_21317192_ChIP-Seq_ERMYB_Mouse0.88092259
131TP53_20018659_ChIP-ChIP_R1E_Mouse0.87384957
132* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.86900206

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system5.04913501
2MP0004272_abnormal_basement_membrane4.15105995
3MP0001879_abnormal_lymphatic_vessel4.13143653
4MP0008438_abnormal_cutaneous_collagen3.85253865
5MP0003279_aneurysm2.92054393
6MP0003705_abnormal_hypodermis_morpholog2.88255651
7MP0005167_abnormal_blood-brain_barrier2.85893680
8MP0004084_abnormal_cardiac_muscle2.67403830
9MP0005257_abnormal_intraocular_pressure2.51905134
10MP0003828_pulmonary_edema2.50630146
11MP0001958_emphysema2.38724952
12MP0005360_urolithiasis2.25291900
13MP0003724_increased_susceptibility_to2.24429217
14MP0005275_abnormal_skin_tensile2.18028700
15MP0004130_abnormal_muscle_cell2.14511010
16MP0002877_abnormal_melanocyte_morpholog2.09059114
17MP0006138_congestive_heart_failure2.04387559
18MP0005623_abnormal_meninges_morphology1.94242800
19MP0003566_abnormal_cell_adhesion1.93155958
20MP0000767_abnormal_smooth_muscle1.90658120
21MP0002295_abnormal_pulmonary_circulatio1.88667905
22MP0001542_abnormal_bone_strength1.86628957
23MP0002139_abnormal_hepatobiliary_system1.74897760
24MP0000751_myopathy1.71676009
25MP0000343_altered_response_to1.67725923
26MP0005670_abnormal_white_adipose1.65468694
27MP0005385_cardiovascular_system_phenoty1.64461383
28MP0001544_abnormal_cardiovascular_syste1.64461383
29MP0004036_abnormal_muscle_relaxation1.63654185
30MP0005503_abnormal_tendon_morphology1.62865258
31MP0002972_abnormal_cardiac_muscle1.59521730
32MP0002837_dystrophic_cardiac_calcinosis1.59346537
33MP0003252_abnormal_bile_duct1.58972883
34MP0003191_abnormal_cellular_cholesterol1.57917504
35MP0005365_abnormal_bile_salt1.55620962
36MP0005085_abnormal_gallbladder_physiolo1.54533723
37MP0005330_cardiomyopathy1.50887562
38MP0005165_increased_susceptibility_to1.49465156
39MP0003091_abnormal_cell_migration1.49111730
40MP0004215_abnormal_myocardial_fiber1.47904995
41MP0004484_altered_response_of1.47903852
42MP0009384_cardiac_valve_regurgitation1.47860681
43MP0000733_abnormal_muscle_development1.44477879
44MP0005595_abnormal_vascular_smooth1.42916633
45MP0000013_abnormal_adipose_tissue1.40150277
46* MP0002128_abnormal_blood_circulation1.37793850
47MP0008775_abnormal_heart_ventricle1.35632344
48MP0002138_abnormal_hepatobiliary_system1.35421505
49MP0010630_abnormal_cardiac_muscle1.34511037
50MP0010386_abnormal_urinary_bladder1.34263861
51MP0000249_abnormal_blood_vessel1.33090812
52MP0010352_gastrointestinal_tract_polyps1.32592614
53MP0001299_abnormal_eye_distance/1.32185065
54MP0010329_abnormal_lipoprotein_level1.30886700
55MP0005508_abnormal_skeleton_morphology1.29996081
56MP0003300_gastrointestinal_ulcer1.29501988
57MP0002332_abnormal_exercise_endurance1.29235590
58MP0005620_abnormal_muscle_contractility1.28676727
59MP0005666_abnormal_adipose_tissue1.22115346
60MP0002060_abnormal_skin_morphology1.20143078
61MP0000604_amyloidosis1.19236213
62MP0005197_abnormal_uvea_morphology1.18704902
63MP0005164_abnormal_response_to1.18252289
64MP0004087_abnormal_muscle_fiber1.15473192
65MP0004233_abnormal_muscle_weight1.15342865
66MP0000230_abnormal_systemic_arterial1.14351465
67MP0009053_abnormal_anal_canal1.13397784
68* MP0001614_abnormal_blood_vessel1.10969835
69MP0006054_spinal_hemorrhage1.10638556
70MP0009780_abnormal_chondrocyte_physiolo1.10582746
71MP0004883_abnormal_blood_vessel1.10311960
72MP0003303_peritoneal_inflammation1.10001753
73MP0004858_abnormal_nervous_system1.08809703
74MP0000537_abnormal_urethra_morphology1.08802145
75MP0000534_abnormal_ureter_morphology1.07723231
76MP0004085_abnormal_heartbeat1.05992351
77MP0001243_abnormal_dermal_layer1.04965373
78MP0004510_myositis1.04509060
79MP0005388_respiratory_system_phenotype1.02904555
80MP0002133_abnormal_respiratory_system1.02904555
81MP0004782_abnormal_surfactant_physiolog1.02656143
82MP0003329_amyloid_beta_deposits0.99466698
83MP0000749_muscle_degeneration0.98460708
84MP0008875_abnormal_xenobiotic_pharmacok0.98167134
85MP0000750_abnormal_muscle_regeneration0.95388361
86MP0005332_abnormal_amino_acid0.94026446
87MP0009840_abnormal_foam_cell0.93407128
88MP0001849_ear_inflammation0.93112249
89* MP0002925_abnormal_cardiovascular_devel0.92517172
90MP0004185_abnormal_adipocyte_glucose0.92515025
91MP0005058_abnormal_lysosome_morphology0.92416765
92MP0000759_abnormal_skeletal_muscle0.90847041
93MP0010030_abnormal_orbit_morphology0.90057446
94MP0005375_adipose_tissue_phenotype0.89434488
95MP0003690_abnormal_glial_cell0.89199321
96MP0003950_abnormal_plasma_membrane0.87768188
97MP0003075_altered_response_to0.87540353
98MP0003448_altered_tumor_morphology0.87245757
99MP0005083_abnormal_biliary_tract0.86948358
100MP0005390_skeleton_phenotype0.86901144
101MP0001533_abnormal_skeleton_physiology0.86625817
102MP0002998_abnormal_bone_remodeling0.86364082
103MP0001756_abnormal_urination0.85999333
104MP0009697_abnormal_copulation0.84963623
105MP0003045_fibrosis0.84167376
106* MP0000266_abnormal_heart_morphology0.82675585
107MP0000747_muscle_weakness0.82065196
108MP0001915_intracranial_hemorrhage0.81575783
109MP0002896_abnormal_bone_mineralization0.81213068
110MP0009764_decreased_sensitivity_to0.80764234
111MP0005193_abnormal_anterior_eye0.79578104
112MP0005023_abnormal_wound_healing0.78690538
113MP0002118_abnormal_lipid_homeostasis0.77885140
114MP0002933_joint_inflammation0.75824715
115MP0009643_abnormal_urine_homeostasis0.74890367
116MP0002971_abnormal_brown_adipose0.74637966
117MP0002108_abnormal_muscle_morphology0.74184926
118* MP0002127_abnormal_cardiovascular_syste0.73930903
119MP0002168_other_aberrant_phenotype0.73915685
120MP0009250_abnormal_appendicular_skeleto0.73720171
121MP0000003_abnormal_adipose_tissue0.73220823
122MP0000609_abnormal_liver_physiology0.72907484
123MP0000163_abnormal_cartilage_morphology0.72593570
124MP0001175_abnormal_lung_morphology0.71490667
125MP0005319_abnormal_enzyme/_coenzyme0.71460484
126MP0008004_abnormal_stomach_pH0.70543793
127MP0003137_abnormal_impulse_conducting0.69635094
128MP0002136_abnormal_kidney_physiology0.69529248
129MP0002113_abnormal_skeleton_development0.68347930
130MP0005171_absent_coat_pigmentation0.68070730
131MP0002135_abnormal_kidney_morphology0.67858057
132MP0005409_darkened_coat_color0.65458313
133MP0002282_abnormal_trachea_morphology0.64034821
134MP0002115_abnormal_skeleton_extremities0.63330932
135MP0003385_abnormal_body_wall0.62859251
136MP0003795_abnormal_bone_structure0.62122036
137MP0003941_abnormal_skin_development0.62054573
138MP0006082_CNS_inflammation0.61497503
139MP0003634_abnormal_glial_cell0.61020200

Predicted human phenotypes

RankGene SetZ-score
1Hematochezia (HP:0002573)4.01389047
2Cervical subluxation (HP:0003308)3.98449275
3Deep venous thrombosis (HP:0002625)3.96443987
4Polycythemia (HP:0001901)3.86350197
5Cerebral aneurysm (HP:0004944)3.81040850
6Broad metatarsal (HP:0001783)3.73548149
7Spontaneous hematomas (HP:0007420)3.70762827
8Abnormality of liposaccharide metabolism (HP:0010968)3.60161136
9Abnormality of glycosphingolipid metabolism (HP:0004343)3.60161136
10Abnormality of glycolipid metabolism (HP:0010969)3.60161136
11Complement deficiency (HP:0004431)3.55749911
12Protrusio acetabuli (HP:0003179)3.51420942
13Esophageal varix (HP:0002040)3.44232668
14Vertebral compression fractures (HP:0002953)3.38314697
15Aortic aneurysm (HP:0004942)3.37379225
16Lymphangioma (HP:0100764)3.33690571
17Premature rupture of membranes (HP:0001788)3.31819206
18Nephritis (HP:0000123)3.26463371
19Aortic dissection (HP:0002647)3.22040344
20Spondylolisthesis (HP:0003302)3.20742459
21Glomerulonephritis (HP:0000099)3.17808515
22Increased connective tissue (HP:0009025)3.15161616
23Short nail (HP:0001799)3.10841141
24Follicular hyperkeratosis (HP:0007502)3.06064684
25Wormian bones (HP:0002645)3.03874130
26Systemic lupus erythematosus (HP:0002725)2.90118676
27Conjunctival telangiectasia (HP:0000524)2.78552410
28Hypoalphalipoproteinemia (HP:0003233)2.76809880
29Abnormality of complement system (HP:0005339)2.76692878
30Sudden death (HP:0001699)2.74380677
31Neurofibrillary tangles (HP:0002185)2.73793595
32Myocardial infarction (HP:0001658)2.72826847
33Vascular tortuosity (HP:0004948)2.70036586
34Joint hemorrhage (HP:0005261)2.63398857
35Arterial tortuosity (HP:0005116)2.62728476
36Muscle fiber splitting (HP:0003555)2.60891981
37Mesangial abnormality (HP:0001966)2.60219435
38Focal segmental glomerulosclerosis (HP:0000097)2.59624920
39Visceral angiomatosis (HP:0100761)2.59037383
40Aneurysm (HP:0002617)2.58757915
41Hemangiomatosis (HP:0007461)2.58722702
42Fragile skin (HP:0001030)2.58105967
43Mitral valve prolapse (HP:0001634)2.52922750
44Cerebral hemorrhage (HP:0001342)2.50093431
45Shallow orbits (HP:0000586)2.49366297
46Xanthomatosis (HP:0000991)2.47832032
47Atrial fibrillation (HP:0005110)2.46912457
48Dysostosis multiplex (HP:0000943)2.44291959
49Ventricular tachycardia (HP:0004756)2.41363326
50Nuclear cataract (HP:0100018)2.40239354
51Abnormality of the vasculature of the conjunctiva (HP:0008054)2.39970672
52Venous insufficiency (HP:0005293)2.35689520
53Mucosal telangiectasiae (HP:0100579)2.35300066
54Reduced subcutaneous adipose tissue (HP:0003758)2.35280355
55Bone cyst (HP:0012062)2.35073423
56Primary atrial arrhythmia (HP:0001692)2.34888005
57Mildly elevated creatine phosphokinase (HP:0008180)2.34455357
58Right ventricular cardiomyopathy (HP:0011663)2.32068630
59Abnormality of dentin (HP:0010299)2.31643506
60Venous abnormality (HP:0002624)2.31598631
61Supraventricular arrhythmia (HP:0005115)2.30042539
62Hyperlipoproteinemia (HP:0010980)2.29508291
63Camptodactyly of toe (HP:0001836)2.28685777
64Mucopolysacchariduria (HP:0008155)2.25909793
65Urinary glycosaminoglycan excretion (HP:0003541)2.25909793
66Cardiovascular calcification (HP:0011915)2.25779263
67Abnormality of polysaccharide metabolism (HP:0011012)2.24522092
68Abnormality of glycosaminoglycan metabolism (HP:0004371)2.24522092
69Abnormality of mucopolysaccharide metabolism (HP:0011020)2.24522092
70Lipoatrophy (HP:0100578)2.24345704
71Slender build (HP:0001533)2.24102773
72Genu recurvatum (HP:0002816)2.23604571
73Tetraparesis (HP:0002273)2.23030160
74Ankle contracture (HP:0006466)2.19997264
75Hyporeflexia of lower limbs (HP:0002600)2.19877774
76Skin nodule (HP:0200036)2.19733680
77Aortic regurgitation (HP:0001659)2.18388526
78Neonatal short-limb short stature (HP:0008921)2.17377236
79Cavernous hemangioma (HP:0001048)2.17217039
80Vacuolated lymphocytes (HP:0001922)2.16333532
81Asymmetric septal hypertrophy (HP:0001670)2.15554243
82Absent frontal sinuses (HP:0002688)2.14271148
83Increased variability in muscle fiber diameter (HP:0003557)2.13186376
84Supraventricular tachycardia (HP:0004755)2.13147418
85Distal lower limb amyotrophy (HP:0008944)2.09553682
86Hemorrhage of the eye (HP:0011885)2.09303967
87Joint laxity (HP:0001388)2.09282509
88Mitral stenosis (HP:0001718)2.08341897
89Cerebral inclusion bodies (HP:0100314)2.07684921
90Hypoglycemic coma (HP:0001325)2.07143395
91Joint stiffness (HP:0001387)2.05395787
92Abnormality of the acetabulum (HP:0003170)2.05060584
93Peritonitis (HP:0002586)2.04584027
94Mitral regurgitation (HP:0001653)2.04223073
95Chondrocalcinosis (HP:0000934)2.03435948
96Aortic valve stenosis (HP:0001650)2.03084118
97Ovoid vertebral bodies (HP:0003300)2.01997052
98Glomerulosclerosis (HP:0000096)2.01963768
99Abnormality of the common coagulation pathway (HP:0010990)2.01290092
100Long toe (HP:0010511)2.01061446
101Hypoplasia of the iris (HP:0007676)2.00081005
102Elbow flexion contracture (HP:0002987)1.99904947
103Abnormality of the ischium (HP:0003174)1.99721383
104Spinal rigidity (HP:0003306)1.97711537
105Difficulty running (HP:0009046)1.97428368
106Short hallux (HP:0010109)1.96977802
107Wrist flexion contracture (HP:0001239)1.96877605
108Axonal loss (HP:0003447)1.96441757
109Hypoplastic ischia (HP:0003175)1.95802462
110Potter facies (HP:0002009)1.94909246
111Facial shape deformation (HP:0011334)1.94909246
112Difficulty climbing stairs (HP:0003551)1.94832155
113Overgrowth (HP:0001548)1.93674482
114Dilatation of the ascending aorta (HP:0005111)1.93650775
115Pulmonary hypertension (HP:0002092)1.93316543
116Striae distensae (HP:0001065)1.92960496
117Abnormality of Sharpey fibers (HP:0100685)1.92840987
118Ectopia lentis (HP:0001083)1.92021557
119Abnormality of carpal bone ossification (HP:0006257)1.91457498
120Vascular calcification (HP:0004934)1.90568691
121Distal lower limb muscle weakness (HP:0009053)1.89643111
122Natal tooth (HP:0000695)1.89103878
123Pulmonary artery stenosis (HP:0004415)1.88486043
124Disproportionate tall stature (HP:0001519)1.87642380
125Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.87058379
126Spinal cord lesions (HP:0100561)1.85723834
127Syringomyelia (HP:0003396)1.85723834
128Nonimmune hydrops fetalis (HP:0001790)1.84977217
129Aplasia/Hypoplasia of the hallux (HP:0008362)1.82474203
130Distal upper limb amyotrophy (HP:0007149)1.82411326
131Upper limb amyotrophy (HP:0009129)1.82411326
132Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.80954725
133Atrophic scars (HP:0001075)1.80658909
134Abnormality of skeletal muscle fiber size (HP:0012084)1.80192826
135Hyperextensible skin (HP:0000974)1.79941552
136Portal hypertension (HP:0001409)1.79612809
137Abnormal ossification of hand bones (HP:0005921)1.79605356
138Hypercholesterolemia (HP:0003124)1.79479042
139Broad face (HP:0000283)1.78905950
140Flexion contracture of toe (HP:0005830)1.78345402
141Joint contractures involving the joints of the feet (HP:0100492)1.78345402
142Tibial bowing (HP:0002982)1.77961225
143Limb-girdle muscle atrophy (HP:0003797)1.77226417
144Blue sclerae (HP:0000592)1.76317711
145Exotropia (HP:0000577)1.76040094
146Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.75831077
147Bladder diverticulum (HP:0000015)1.75805262
148Soft skin (HP:0000977)1.74895101
149Lower limb amyotrophy (HP:0007210)1.74762516
150Osteolytic defects of the phalanges of the hand (HP:0009771)1.74602537
151Osteolytic defects of the hand bones (HP:0009699)1.74602537
152Stroke (HP:0001297)1.74464031
153Type 1 muscle fiber predominance (HP:0003803)1.74104108
154Generalized amyotrophy (HP:0003700)1.73755251
155Bradycardia (HP:0001662)1.73740037
156Interstitial pulmonary disease (HP:0006530)1.73606719
157Hypolipoproteinemia (HP:0010981)1.73070512
158Wide anterior fontanel (HP:0000260)1.71501263
159Coxa vara (HP:0002812)1.71189483
160Flared iliac wings (HP:0002869)1.68716837
161Upper motor neuron abnormality (HP:0002127)1.67364005

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.94953479
2KDR4.51842210
3TGFBR24.28400469
4MST1R3.13071506
5INSRR2.58547279
6TTN2.57792384
7LIMK12.56352742
8TRIB32.56213949
9EPHB22.46275491
10EPHA22.38941505
11IRAK32.38760148
12MOS2.33132860
13MYLK2.29668903
14ERBB42.21917721
15TESK12.10425308
16PDGFRA2.00405019
17PTK2B1.89477539
18AKT31.89192703
19RIPK11.84571951
20TGFBR11.66792544
21ERN11.58875820
22EPHA31.58063176
23CAMK1D1.50584819
24PKN21.49759210
25DMPK1.46448274
26FGFR41.41829155
27FER1.35382833
28PTK61.32367313
29NEK91.30952450
30WNK41.28652008
31LATS11.26310442
32ICK1.23645696
33CAMK1G1.18818676
34FGFR31.18537005
35STK381.06952248
36PDK21.04550016
37NME21.01594116
38MAPK121.01548068
39JAK11.00876131
40SIK10.99510229
41PDGFRB0.98339670
42PIK3CA0.98010828
43ROCK20.96811349
44PAK60.94593246
45CDC42BPA0.93599515
46GRK70.93333837
47BCR0.92586198
48MAP2K30.91643346
49PRKD10.91523774
50OBSCN0.91375098
51PRKAA20.91051229
52CAMKK20.90608655
53FGFR20.89013893
54PRKCH0.88783642
55IGF1R0.84422183
56TYK20.84142813
57MAP3K60.82279440
58LMTK20.81818055
59MAP3K30.81762893
60PTK20.80189496
61SCYL20.80179219
62FRK0.79212371
63KIT0.78929250
64MAP3K70.77231463
65NUAK10.76836516
66PHKG10.76687806
67PHKG20.76687806
68TRPM70.73390614
69ROCK10.70426522
70DDR20.69438919
71KSR10.69406690
72GSK3A0.69082301
73PAK30.68770837
74CSK0.68349191
75PAK20.68062491
76RET0.66693944
77LATS20.66454036
78STK240.65914047
79GRK10.63912153
80RPS6KA20.63442752
81ARAF0.63387894
82LRRK20.62134206
83MAP2K70.62073013
84MAP2K10.61882403
85CAMK40.59701935
86STK100.59555659
87MTOR0.59546474
88PRKCE0.59325716
89ABL20.59137103
90TBK10.58964291
91MARK20.57922628
92PDPK10.57786963
93EGFR0.56369888
94FLT30.56351888
95PLK20.55182970
96BMX0.54500854
97INSR0.53011173
98MARK10.52861074
99MAP3K140.52832470
100ERBB30.52590062
101ILK0.52571126
102PIM20.51112115
103EPHB10.50090490
104PAK40.49823245
105BCKDK0.49146134
106MAPK70.48778883
107STK390.48244829
108SGK30.47876973
109SIK30.46809662
110STK38L0.46675379
111JAK20.46564165
112SRC0.45995920
113MAPKAPK30.42798299
114NTRK10.39376479
115FGFR10.38881952
116CDK80.38480867
117CDK60.38349131
118PRKD20.37972435
119CAMK2D0.37475166
120PRKG20.37401195
121SGK20.36433908
122CAMK2G0.35429771
123TRIM280.34967569
124MAP3K120.34513739
125ABL10.34406017
126PRKCQ0.34039460
127MELK0.32763092
128ITK0.32641891
129ADRBK10.30901550
130MARK30.30133929
131TEC0.29664467
132GRK50.29493746
133TAOK20.29271984
134HCK0.28991031
135MET0.28641512
136FGR0.28467222
137CSNK1A1L0.23505371
138CAMK2B0.22701972
139ZAP700.20511169
140CLK10.20391721

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046102.61858961
2Other glycan degradation_Homo sapiens_hsa005112.40206307
3ECM-receptor interaction_Homo sapiens_hsa045122.36154858
4Staphylococcus aureus infection_Homo sapiens_hsa051502.21051711
5Fatty acid degradation_Homo sapiens_hsa000712.18008370
6PPAR signaling pathway_Homo sapiens_hsa033202.04566607
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.01432523
8Primary bile acid biosynthesis_Homo sapiens_hsa001201.99705346
9Focal adhesion_Homo sapiens_hsa045101.95822125
10Dilated cardiomyopathy_Homo sapiens_hsa054141.81605268
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.76217640
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.73634770
13Propanoate metabolism_Homo sapiens_hsa006401.68754766
14Adherens junction_Homo sapiens_hsa045201.67435593
15Fatty acid metabolism_Homo sapiens_hsa012121.66079913
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.65993534
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60007192
18Caffeine metabolism_Homo sapiens_hsa002321.52311394
19Arginine biosynthesis_Homo sapiens_hsa002201.49502995
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.43827831
21Tryptophan metabolism_Homo sapiens_hsa003801.42205130
22Nitrogen metabolism_Homo sapiens_hsa009101.41329963
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.39654936
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.38845867
25Amoebiasis_Homo sapiens_hsa051461.36631691
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.34962225
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.33473870
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33246137
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.30155756
30Bladder cancer_Homo sapiens_hsa052191.29672338
31Bile secretion_Homo sapiens_hsa049761.29483853
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25823576
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22146316
34Vibrio cholerae infection_Homo sapiens_hsa051101.18472952
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.11249908
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.10665400
37Viral myocarditis_Homo sapiens_hsa054161.10463876
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09789762
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04993322
40Malaria_Homo sapiens_hsa051441.04305376
41TNF signaling pathway_Homo sapiens_hsa046681.03344949
42Protein digestion and absorption_Homo sapiens_hsa049741.02983832
43Rheumatoid arthritis_Homo sapiens_hsa053231.02411469
44Insulin resistance_Homo sapiens_hsa049311.00017100
45Proteoglycans in cancer_Homo sapiens_hsa052050.99869374
46Small cell lung cancer_Homo sapiens_hsa052220.99593506
47Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99369338
48Shigellosis_Homo sapiens_hsa051310.98571397
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97638226
50Sphingolipid metabolism_Homo sapiens_hsa006000.96908849
51Galactose metabolism_Homo sapiens_hsa000520.96070575
52Rap1 signaling pathway_Homo sapiens_hsa040150.93009056
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89801952
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.89135135
55Renin-angiotensin system_Homo sapiens_hsa046140.88819181
56MicroRNAs in cancer_Homo sapiens_hsa052060.88584140
57Peroxisome_Homo sapiens_hsa041460.87390088
58Pathways in cancer_Homo sapiens_hsa052000.86532838
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86261293
60Endocytosis_Homo sapiens_hsa041440.85285544
61Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84689830
62Starch and sucrose metabolism_Homo sapiens_hsa005000.84368923
63Toxoplasmosis_Homo sapiens_hsa051450.84271201
64Hippo signaling pathway_Homo sapiens_hsa043900.81195116
65PI3K-Akt signaling pathway_Homo sapiens_hsa041510.81187232
66* Axon guidance_Homo sapiens_hsa043600.81109858
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.80771649
68Butanoate metabolism_Homo sapiens_hsa006500.80222259
69Platelet activation_Homo sapiens_hsa046110.79145804
70Prion diseases_Homo sapiens_hsa050200.79065452
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78225729
72Melanoma_Homo sapiens_hsa052180.78023219
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77347910
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76773458
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.74920245
76Phagosome_Homo sapiens_hsa041450.74080000
77Osteoclast differentiation_Homo sapiens_hsa043800.73832770
78Renin secretion_Homo sapiens_hsa049240.72820755
79Dorso-ventral axis formation_Homo sapiens_hsa043200.72616291
80Lysine degradation_Homo sapiens_hsa003100.71225666
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70272348
82Tight junction_Homo sapiens_hsa045300.69826829
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69740316
84Lysosome_Homo sapiens_hsa041420.69323296
85ABC transporters_Homo sapiens_hsa020100.69269453
86beta-Alanine metabolism_Homo sapiens_hsa004100.69153741
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68083230
88Pertussis_Homo sapiens_hsa051330.67996501
89Notch signaling pathway_Homo sapiens_hsa043300.67336542
90Mineral absorption_Homo sapiens_hsa049780.65948640
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65742136
92Chronic myeloid leukemia_Homo sapiens_hsa052200.64255688
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63524538
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.62597141
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60102706
96Fatty acid biosynthesis_Homo sapiens_hsa000610.58573622
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57536944
98Sulfur metabolism_Homo sapiens_hsa009200.57484569
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.57247639
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57228775
101Fat digestion and absorption_Homo sapiens_hsa049750.55505356
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.53855960
103Ovarian steroidogenesis_Homo sapiens_hsa049130.53090022
104VEGF signaling pathway_Homo sapiens_hsa043700.52890139
105Retinol metabolism_Homo sapiens_hsa008300.52770430
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52583188
107Leishmaniasis_Homo sapiens_hsa051400.51359021
108Glycerolipid metabolism_Homo sapiens_hsa005610.50922029
109HIF-1 signaling pathway_Homo sapiens_hsa040660.50896758
110Phenylalanine metabolism_Homo sapiens_hsa003600.50168876
111Glioma_Homo sapiens_hsa052140.48788053
112GnRH signaling pathway_Homo sapiens_hsa049120.48596019
113N-Glycan biosynthesis_Homo sapiens_hsa005100.48101303
114Pancreatic cancer_Homo sapiens_hsa052120.47599922
115Salmonella infection_Homo sapiens_hsa051320.47129444
116Chemical carcinogenesis_Homo sapiens_hsa052040.46544536
117Renal cell carcinoma_Homo sapiens_hsa052110.46468350
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46398525
119Tyrosine metabolism_Homo sapiens_hsa003500.45613737
120Pyruvate metabolism_Homo sapiens_hsa006200.45611610
121TGF-beta signaling pathway_Homo sapiens_hsa043500.45430190
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45425787
123AMPK signaling pathway_Homo sapiens_hsa041520.45255639
124Basal cell carcinoma_Homo sapiens_hsa052170.45039302
125Estrogen signaling pathway_Homo sapiens_hsa049150.44508386
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.44055785
127Fructose and mannose metabolism_Homo sapiens_hsa000510.43433054
128Tuberculosis_Homo sapiens_hsa051520.43300293
129Gap junction_Homo sapiens_hsa045400.42813230
130Ras signaling pathway_Homo sapiens_hsa040140.42504081
131Fatty acid elongation_Homo sapiens_hsa000620.42329873
132cAMP signaling pathway_Homo sapiens_hsa040240.42100402
133Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41097083
134Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40964017
135Insulin signaling pathway_Homo sapiens_hsa049100.40479145
136Prostate cancer_Homo sapiens_hsa052150.40328037
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39949713
138Apoptosis_Homo sapiens_hsa042100.39818676
139Melanogenesis_Homo sapiens_hsa049160.39795129
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39590478
141Glucagon signaling pathway_Homo sapiens_hsa049220.39073987
142Carbon metabolism_Homo sapiens_hsa012000.38284913
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37739633
144Circadian rhythm_Homo sapiens_hsa047100.37497006
145Hepatitis C_Homo sapiens_hsa051600.35893430
146African trypanosomiasis_Homo sapiens_hsa051430.35659868
147Hepatitis B_Homo sapiens_hsa051610.31324133
148Endometrial cancer_Homo sapiens_hsa052130.31093795

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