NRROS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.17021268
2negative regulation of erythrocyte differentiation (GO:0045647)4.98094162
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.84510008
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.84510008
5positive regulation of gamma-delta T cell activation (GO:0046645)4.75339493
6regulation of B cell receptor signaling pathway (GO:0050855)4.73019743
7antigen processing and presentation of endogenous antigen (GO:0019883)4.68188245
8positive regulation of B cell differentiation (GO:0045579)4.58361740
9neutrophil activation involved in immune response (GO:0002283)4.37477756
10regulation of interferon-beta biosynthetic process (GO:0045357)4.32582766
11modulation by symbiont of host defense response (GO:0052031)4.14510958
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.14510958
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.14510958
14positive regulation by organism of defense response of other organism involved in symbiotic interact4.14510958
15modulation by symbiont of host immune response (GO:0052553)4.14510958
16positive regulation by symbiont of host defense response (GO:0052509)4.14510958
17Arp2/3 complex-mediated actin nucleation (GO:0034314)4.12873195
18immunoglobulin mediated immune response (GO:0016064)4.09472704
19detection of other organism (GO:0098543)4.07023147
20detection of bacterium (GO:0016045)3.98506005
21cellular response to exogenous dsRNA (GO:0071360)3.95791378
22regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.93912146
23negative regulation of phagocytosis (GO:0050765)3.92706807
24regulation of B cell differentiation (GO:0045577)3.89998792
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.85657128
26mast cell activation (GO:0045576)3.78402299
27response to peptidoglycan (GO:0032494)3.72965143
28macrophage activation involved in immune response (GO:0002281)3.71251374
29positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.69939157
30B cell receptor signaling pathway (GO:0050853)3.67829737
31defense response to protozoan (GO:0042832)3.62013080
32respiratory burst (GO:0045730)3.59225941
33regulation of leukocyte degranulation (GO:0043300)3.54629691
34positive thymic T cell selection (GO:0045059)3.53111103
35regulation of myeloid leukocyte mediated immunity (GO:0002886)3.50678569
36pinocytosis (GO:0006907)3.50233252
37neutrophil mediated immunity (GO:0002446)3.46475487
38myeloid dendritic cell activation (GO:0001773)3.45750675
39negative thymic T cell selection (GO:0045060)3.45005535
40myeloid cell activation involved in immune response (GO:0002275)3.44438791
41regulation of MHC class II biosynthetic process (GO:0045346)3.44154061
42neutrophil activation (GO:0042119)3.41361737
43response to protozoan (GO:0001562)3.36893163
44positive regulation of antigen processing and presentation (GO:0002579)3.36886350
45germinal center formation (GO:0002467)3.30354258
46detection of external biotic stimulus (GO:0098581)3.29722372
47positive regulation of interferon-alpha production (GO:0032727)3.27828499
48regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.27004502
49response to muramyl dipeptide (GO:0032495)3.25767893
50positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.25494753
51interferon-gamma-mediated signaling pathway (GO:0060333)3.25409433
52negative T cell selection (GO:0043383)3.25264439
53ribosomal small subunit assembly (GO:0000028)3.22712029
54negative regulation of T cell mediated immunity (GO:0002710)3.22364960
55antigen processing and presentation via MHC class Ib (GO:0002475)3.21780988
56B cell mediated immunity (GO:0019724)3.20795243
57actin nucleation (GO:0045010)3.18251391
58cellular response to zinc ion (GO:0071294)3.16402851
59negative regulation of lymphocyte mediated immunity (GO:0002707)3.15702570
60myeloid dendritic cell differentiation (GO:0043011)3.14803173
61granulocyte activation (GO:0036230)3.14352464
62cellular extravasation (GO:0045123)3.13809378
63cellular response to type I interferon (GO:0071357)3.13054310
64type I interferon signaling pathway (GO:0060337)3.13054310
65response to type I interferon (GO:0034340)3.11728126
66T cell migration (GO:0072678)3.09935157
67leukocyte aggregation (GO:0070486)3.09886665
68regulation of interferon-alpha production (GO:0032647)3.09670954
69regulation of gamma-delta T cell activation (GO:0046643)3.09168545
70response to interferon-beta (GO:0035456)3.08786746
71negative regulation of leukocyte mediated immunity (GO:0002704)3.08228169
72regulation of gamma-delta T cell differentiation (GO:0045586)3.06439274
73regulation of mast cell activation (GO:0033003)3.06242005
74positive regulation of mast cell activation involved in immune response (GO:0033008)3.05000466
75positive regulation of mast cell degranulation (GO:0043306)3.05000466
76regulation of interleukin-12 biosynthetic process (GO:0045075)3.02089261
77megakaryocyte development (GO:0035855)3.02064804
78cellular response to interferon-beta (GO:0035458)2.99958049
79T cell homeostasis (GO:0043029)2.99890784
80detection of biotic stimulus (GO:0009595)2.98639270
81regulation of mast cell degranulation (GO:0043304)2.98604763
82mannose metabolic process (GO:0006013)2.97054985
83myeloid leukocyte activation (GO:0002274)2.95244060
84microglial cell activation (GO:0001774)2.94542203
85mature B cell differentiation (GO:0002335)2.94475271
86T cell selection (GO:0045058)2.94213692
87positive regulation of granulocyte differentiation (GO:0030854)2.93972464
88negative regulation of granulocyte differentiation (GO:0030853)2.93794437
89definitive hemopoiesis (GO:0060216)2.92839766
90production of molecular mediator involved in inflammatory response (GO:0002532)2.91707261
91detection of molecule of bacterial origin (GO:0032490)2.90443357
92regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.90169216
93B cell homeostasis (GO:0001782)2.88815546
94regulation of antigen processing and presentation (GO:0002577)2.87465422
95regulation of regulated secretory pathway (GO:1903305)2.86592175
96regulation of interleukin-2 biosynthetic process (GO:0045076)2.85827045
97positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.85145464
98thymic T cell selection (GO:0045061)2.84763728
99mature B cell differentiation involved in immune response (GO:0002313)2.84271062
100mast cell degranulation (GO:0043303)2.83918810
101mast cell activation involved in immune response (GO:0002279)2.83918810
102T-helper 1 type immune response (GO:0042088)2.82888727
103cellular response to thyroid hormone stimulus (GO:0097067)2.81883544
104response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.81054076
105response to host immune response (GO:0052572)2.81054076
106negative regulation of cell killing (GO:0031342)2.80764738
107negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.80764738
108lymphocyte homeostasis (GO:0002260)2.80263394
109macrophage activation (GO:0042116)2.79763844
110NIK/NF-kappaB signaling (GO:0038061)2.79501304
111regulation of dendritic cell antigen processing and presentation (GO:0002604)2.78192589
112myeloid leukocyte mediated immunity (GO:0002444)2.77585450
113leukocyte degranulation (GO:0043299)2.77045650
114dendritic cell differentiation (GO:0097028)2.75325525
115positive T cell selection (GO:0043368)2.75152925
116negative regulation of cytokine production involved in immune response (GO:0002719)2.75019620
117positive regulation of mast cell activation (GO:0033005)2.74046544
118negative regulation of interleukin-6 production (GO:0032715)2.72946986
119regulation of mast cell activation involved in immune response (GO:0033006)2.72853190
120lipopolysaccharide-mediated signaling pathway (GO:0031663)2.72768870
121regulation of alpha-beta T cell proliferation (GO:0046640)2.72468332
122positive regulation of interferon-beta production (GO:0032728)2.71813977
123leukocyte mediated cytotoxicity (GO:0001909)2.71740025
124negative regulation of innate immune response (GO:0045824)2.70580321
125negative regulation of interleukin-12 production (GO:0032695)2.62533541
126positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.61740514
127cellular response to dsRNA (GO:0071359)2.61564501
128positive regulation of B cell activation (GO:0050871)2.60489972
129negative regulation of B cell proliferation (GO:0030889)2.59090775
130response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.58930068
131response to host (GO:0075136)2.58930068
132response to host defenses (GO:0052200)2.58930068
133angiogenesis involved in wound healing (GO:0060055)2.57462360
134leukocyte homeostasis (GO:0001776)2.57200523
135negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.56346261

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.17896902
2E2F7_22180533_ChIP-Seq_HELA_Human5.02411831
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.38357178
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.21609349
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.80236684
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.77429963
7SCL_19346495_ChIP-Seq_HPC-7_Human3.40556403
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.26176504
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.24575748
10IRF8_27001747_Chip-Seq_BMDM_Mouse3.21500539
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.14469925
12MYB_21317192_ChIP-Seq_ERMYB_Mouse3.12605720
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.98646531
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.83764571
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.80229632
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.78939907
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.78147594
18SPI1_23547873_ChIP-Seq_NB4_Human2.66008569
19VDR_21846776_ChIP-Seq_THP-1_Human2.63739047
20MYC_22102868_ChIP-Seq_BL_Human2.57902893
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.44448212
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.43583163
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.29965886
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.27721730
25MYB_26560356_Chip-Seq_TH2_Human2.23898615
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.20438027
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.19477906
28BRD4_27068464_Chip-Seq_AML-cells_Mouse2.17874739
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.16850511
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.16767261
31VDR_24763502_ChIP-Seq_THP-1_Human2.15947441
32RUNX1_22412390_ChIP-Seq_EML_Mouse2.08771969
33MAF_26560356_Chip-Seq_TH1_Human2.01680876
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.97254259
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.93747529
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.93662140
37RUNX_20019798_ChIP-Seq_JUKART_Human1.92323412
38SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.91091771
39MYB_26560356_Chip-Seq_TH1_Human1.90032648
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.87868036
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.85159020
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.82488156
43KDM2B_26808549_Chip-Seq_DND41_Human1.78300624
44SPI1_23127762_ChIP-Seq_K562_Human1.75615502
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.75562167
46UTX_26944678_Chip-Seq_JUKART_Human1.72642365
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66877464
48PU_27001747_Chip-Seq_BMDM_Mouse1.63535292
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.62558070
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.61190767
51LXR_22292898_ChIP-Seq_THP-1_Human1.60951800
52VDR_24787735_ChIP-Seq_THP-1_Human1.60905971
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.60877126
54TCF7_22412390_ChIP-Seq_EML_Mouse1.58939643
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.58091806
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.57806044
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.56168232
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.55175326
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53220335
60GATA1_22383799_ChIP-Seq_G1ME_Mouse1.50921149
61FOXM1_23109430_ChIP-Seq_U2OS_Human1.47845577
62GATA1_22025678_ChIP-Seq_K562_Human1.44649224
63GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.42352785
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.38553791
65GATA1_19941826_ChIP-Seq_K562_Human1.37392334
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34712186
67PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29855740
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.29506275
69CIITA_25753668_ChIP-Seq_RAJI_Human1.26711344
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25522528
71VDR_23849224_ChIP-Seq_CD4+_Human1.24987425
72GATA3_27048872_Chip-Seq_THYMUS_Human1.24946084
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21802378
74NCOR1_26117541_ChIP-Seq_K562_Human1.20588738
75FOXP3_21729870_ChIP-Seq_TREG_Human1.18991911
76MAF_26560356_Chip-Seq_TH2_Human1.18588001
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17186449
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16581938
79CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16384757
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.15823020
81GATA1_19941827_ChIP-Seq_MEL_Mouse1.14697424
82NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.13614438
83GATA3_26560356_Chip-Seq_TH2_Human1.12044118
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09167047
85KDM2B_26808549_Chip-Seq_JURKAT_Human1.09155796
86FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.09072597
87BCOR_27268052_Chip-Seq_Bcells_Human1.06706333
88BCL6_27268052_Chip-Seq_Bcells_Human1.06508799
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05688615
90TFEB_21752829_ChIP-Seq_HELA_Human1.05124342
91GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05112025
92RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04548627
93CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03412604
94PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02986194
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02926454
96CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01697785
97IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00640816
98MYC_18555785_ChIP-Seq_MESCs_Mouse0.99448148
99SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99311722
100CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97527421
101GATA2_19941826_ChIP-Seq_K562_Human0.95431382
102PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93959741
103PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91256352
104GABP_17652178_ChIP-ChIP_JURKAT_Human0.90839285
105E2F1_21310950_ChIP-Seq_MCF-7_Human0.90592577
106SPI1_20517297_ChIP-Seq_HL60_Human0.90002135
107STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88778537
108ELK3_25401928_ChIP-Seq_HUVEC_Human0.87880400
109NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87876006
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87799956
111KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87336938
112SRF_21415370_ChIP-Seq_HL-1_Mouse0.86954819
113VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86810584
114ELK1_19687146_ChIP-ChIP_HELA_Human0.84967290
115EST1_17652178_ChIP-ChIP_JURKAT_Human0.84706724
116CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84292602
117GATA2_21666600_ChIP-Seq_HMVEC_Human0.83296853
118RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82873411
119KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.82074599
120ETS1_22383799_ChIP-Seq_G1ME_Mouse0.81945361
121P68_20966046_ChIP-Seq_HELA_Human0.81744043
122FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80525188
123MYC_18358816_ChIP-ChIP_MESCs_Mouse0.79641749

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.89589013
2MP0009785_altered_susceptibility_to3.13399747
3MP0003436_decreased_susceptibility_to3.12469180
4MP0005671_abnormal_response_to3.03083019
5MP0001800_abnormal_humoral_immune3.02011073
6MP0000685_abnormal_immune_system2.95424746
7MP0002419_abnormal_innate_immunity2.95378626
8MP0002396_abnormal_hematopoietic_system2.93675854
9MP0001790_abnormal_immune_system2.92672162
10MP0005387_immune_system_phenotype2.92672162
11MP0005000_abnormal_immune_tolerance2.89451260
12MP0002452_abnormal_antigen_presenting2.84735251
13MP0005025_abnormal_response_to2.82940404
14MP0002148_abnormal_hypersensitivity_rea2.78541858
15MP0002723_abnormal_immune_serum2.66886983
16MP0002420_abnormal_adaptive_immunity2.64290706
17MP0001819_abnormal_immune_cell2.63085168
18MP0003303_peritoneal_inflammation2.55306791
19MP0005464_abnormal_platelet_physiology2.50513121
20MP0002398_abnormal_bone_marrow2.35399385
21MP0000716_abnormal_immune_system2.17839357
22MP0003724_increased_susceptibility_to2.17136403
23MP0003763_abnormal_thymus_physiology2.14751299
24MP0005058_abnormal_lysosome_morphology2.11942932
25MP0005174_abnormal_tail_pigmentation2.09987388
26MP0002166_altered_tumor_susceptibility2.05854998
27MP0000689_abnormal_spleen_morphology2.01508753
28MP0004808_abnormal_hematopoietic_stem1.99876973
29MP0001853_heart_inflammation1.98784455
30MP0002405_respiratory_system_inflammati1.95614410
31MP0002722_abnormal_immune_system1.89785748
32MP0005397_hematopoietic_system_phenotyp1.87834981
33MP0001545_abnormal_hematopoietic_system1.87834981
34MP0002429_abnormal_blood_cell1.87296723
35MP0006082_CNS_inflammation1.82177547
36MP0003172_abnormal_lysosome_physiology1.81844786
37MP0000465_gastrointestinal_hemorrhage1.81209391
38MP0001845_abnormal_inflammatory_respons1.79604170
39MP0009333_abnormal_splenocyte_physiolog1.78895674
40MP0005451_abnormal_body_composition1.74395776
41MP0010155_abnormal_intestine_physiology1.72830353
42MP0002006_tumorigenesis1.72112682
43MP0009278_abnormal_bone_marrow1.62932241
44MP0001873_stomach_inflammation1.61107910
45MP0003183_abnormal_peptide_metabolism1.57731029
46MP0004510_myositis1.55555250
47MP0003300_gastrointestinal_ulcer1.55315468
48MP0000569_abnormal_digit_pigmentation1.51679155
49MP0005075_abnormal_melanosome_morpholog1.50188527
50MP0001533_abnormal_skeleton_physiology1.50040376
51MP0000703_abnormal_thymus_morphology1.44943847
52MP0000490_abnormal_crypts_of1.43696812
53MP0005310_abnormal_salivary_gland1.43654815
54MP0008469_abnormal_protein_level1.43256943
55MP0008057_abnormal_DNA_replication1.38358778
56MP0004947_skin_inflammation1.34315612
57MP0003191_abnormal_cellular_cholesterol1.33342839
58MP0008260_abnormal_autophagy1.32710898
59MP0000604_amyloidosis1.26325095
60MP0000015_abnormal_ear_pigmentation1.22376078
61MP0003866_abnormal_defecation1.19708346
62MP0000858_altered_metastatic_potential1.18862638
63MP0003448_altered_tumor_morphology1.18134720
64MP0000343_altered_response_to1.17962005
65MP0002019_abnormal_tumor_incidence1.01881491
66MP0002933_joint_inflammation1.01832385
67MP0001851_eye_inflammation1.01111063
68MP0002095_abnormal_skin_pigmentation0.99731515
69MP0009764_decreased_sensitivity_to0.98845403
70MP0010094_abnormal_chromosome_stability0.97134815
71MP0010307_abnormal_tumor_latency0.93702047
72MP0006054_spinal_hemorrhage0.91664648
73MP0004381_abnormal_hair_follicle0.90276110
74MP0002138_abnormal_hepatobiliary_system0.89991543
75MP0003690_abnormal_glial_cell0.89381416
76MP0002998_abnormal_bone_remodeling0.88545198
77MP0009840_abnormal_foam_cell0.88071521
78MP0003693_abnormal_embryo_hatching0.85762435
79MP0003077_abnormal_cell_cycle0.85640507
80MP0008007_abnormal_cellular_replicative0.85475150
81MP0003828_pulmonary_edema0.83732928
82MP0001986_abnormal_taste_sensitivity0.81667336
83MP0003806_abnormal_nucleotide_metabolis0.80967536
84MP0000371_diluted_coat_color0.78749219
85MP0002009_preneoplasia0.76666633
86MP0004883_abnormal_blood_vessel0.76362314
87MP0009763_increased_sensitivity_to0.75584052
88MP0008058_abnormal_DNA_repair0.74642775
89MP0003943_abnormal_hepatobiliary_system0.74332648
90MP0002132_abnormal_respiratory_system0.74305418
91MP0001879_abnormal_lymphatic_vessel0.71127049
92MP0008004_abnormal_stomach_pH0.69563200
93MP0000249_abnormal_blood_vessel0.69535781
94MP0002877_abnormal_melanocyte_morpholog0.68095802
95MP0005076_abnormal_cell_differentiation0.68060179
96MP0009765_abnormal_xenobiotic_induced0.67749762
97MP0000313_abnormal_cell_death0.66871680
98MP0003075_altered_response_to0.66046238
99MP0003111_abnormal_nucleus_morphology0.65407087
100MP0005166_decreased_susceptibility_to0.65376230
101MP0001663_abnormal_digestive_system0.64119141
102MP0005390_skeleton_phenotype0.63912882
103MP0005164_abnormal_response_to0.63843203
104MP0008874_decreased_physiological_sensi0.58400812
105MP0003091_abnormal_cell_migration0.57579918
106MP0003656_abnormal_erythrocyte_physiolo0.56983630
107MP0000609_abnormal_liver_physiology0.55176034
108MP0005167_abnormal_blood-brain_barrier0.54829938
109MP0003795_abnormal_bone_structure0.54062381
110MP0008873_increased_physiological_sensi0.53520020
111MP0004185_abnormal_adipocyte_glucose0.52804359
112MP0009115_abnormal_fat_cell0.52039987
113MP0003566_abnormal_cell_adhesion0.50561694
114MP0010352_gastrointestinal_tract_polyps0.50296658
115MP0003453_abnormal_keratinocyte_physiol0.50016014
116MP0002075_abnormal_coat/hair_pigmentati0.49846624
117MP0003045_fibrosis0.49661140
118MP0005647_abnormal_sex_gland0.49340589
119MP0002136_abnormal_kidney_physiology0.47194536
120MP0000598_abnormal_liver_morphology0.46862462
121MP0002928_abnormal_bile_duct0.46223612

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.81666169
2Recurrent bacterial skin infections (HP:0005406)5.30649407
3Eczematoid dermatitis (HP:0000976)4.86312996
4Abnormal delayed hypersensitivity skin test (HP:0002963)4.84967027
5Recurrent viral infections (HP:0004429)4.80322497
6Panhypogammaglobulinemia (HP:0003139)4.58112392
7Recurrent fungal infections (HP:0002841)4.48145731
8Elevated erythrocyte sedimentation rate (HP:0003565)4.41647388
9Chronic mucocutaneous candidiasis (HP:0002728)4.34161995
10Recurrent cutaneous fungal infections (HP:0011370)4.34161995
11Myositis (HP:0100614)4.26320768
12Recurrent skin infections (HP:0001581)4.13557789
13Chronic otitis media (HP:0000389)4.12140861
14Agammaglobulinemia (HP:0004432)4.11159553
15Colitis (HP:0002583)4.04742826
16IgM deficiency (HP:0002850)4.04550285
17Thrombocytosis (HP:0001894)3.86462017
18Meningitis (HP:0001287)3.72016884
19Inflammation of the large intestine (HP:0002037)3.65690125
20Abnormality of macrophages (HP:0004311)3.64189181
21Mediastinal lymphadenopathy (HP:0100721)3.60472074
22Abnormality of T cell physiology (HP:0011840)3.56209554
23Gastrointestinal inflammation (HP:0004386)3.51193339
24Recurrent gram-negative bacterial infections (HP:0005420)3.45371466
25Vacuolated lymphocytes (HP:0001922)3.44153229
26Cellulitis (HP:0100658)3.41818803
27Petechiae (HP:0000967)3.36098573
28Chronic obstructive pulmonary disease (HP:0006510)3.25546561
29Obstructive lung disease (HP:0006536)3.25546561
30Orchitis (HP:0100796)3.18251961
31Vasculitis (HP:0002633)3.03456958
32Recurrent bronchitis (HP:0002837)3.02124404
33Abnormality of T cells (HP:0002843)2.98667788
34Increased cerebral lipofuscin (HP:0011813)2.96960029
35Retrobulbar optic neuritis (HP:0100654)2.92019645
36Optic neuritis (HP:0100653)2.92019645
37Increased neuronal autofluorescent lipopigment (HP:0002074)2.90208087
38Spontaneous hematomas (HP:0007420)2.87213829
39Loss of speech (HP:0002371)2.86203669
40Prolonged bleeding time (HP:0003010)2.82925485
41Encephalitis (HP:0002383)2.81003394
42Purpura (HP:0000979)2.78359742
43Gingivitis (HP:0000230)2.72181965
44Periodontitis (HP:0000704)2.70067468
45Lymphopenia (HP:0001888)2.66380396
46Systemic lupus erythematosus (HP:0002725)2.65127398
47Recurrent lower respiratory tract infections (HP:0002783)2.61947391
48Gastrointestinal infarctions (HP:0005244)2.61496885
49Epistaxis (HP:0000421)2.60989063
50Type 2 muscle fiber atrophy (HP:0003554)2.59873814
51Abnormality of cells of the lymphoid lineage (HP:0012140)2.59507281
52Hepatosplenomegaly (HP:0001433)2.56983309
53Interstitial pulmonary disease (HP:0006530)2.55147531
54Abnormality of the prostate (HP:0008775)2.55018866
55Osteomyelitis (HP:0002754)2.54964464
56Muscle fiber atrophy (HP:0100295)2.54153065
57Increased serum ferritin (HP:0003281)2.49563448
58Leukocytosis (HP:0001974)2.48058394
59Eosinophilia (HP:0001880)2.47348876
60Viral hepatitis (HP:0006562)2.46331860
61Recurrent pneumonia (HP:0006532)2.44447577
62Autoimmune thrombocytopenia (HP:0001973)2.41298900
63Pustule (HP:0200039)2.39067200
64Granulocytopenia (HP:0001913)2.38788882
65Pulmonary infiltrates (HP:0002113)2.37298784
66B lymphocytopenia (HP:0010976)2.36933630
67Abnormality of B cell number (HP:0010975)2.36933630
68Increased IgM level (HP:0003496)2.35476088
69Dysostosis multiplex (HP:0000943)2.35326748
70Thyroiditis (HP:0100646)2.34894008
71Arterial thrombosis (HP:0004420)2.29946668
72Abnormality of mucopolysaccharide metabolism (HP:0011020)2.28848086
73Abnormality of polysaccharide metabolism (HP:0011012)2.28848086
74Abnormality of glycosaminoglycan metabolism (HP:0004371)2.28848086
75Agnosia (HP:0010524)2.28450306
76Abnormal platelet function (HP:0011869)2.28347566
77Impaired platelet aggregation (HP:0003540)2.28347566
78Stomatitis (HP:0010280)2.27744885
79Gingival bleeding (HP:0000225)2.27225419
80Nasal polyposis (HP:0100582)2.26678562
81Gastrointestinal stroma tumor (HP:0100723)2.25645901
82Abnormality of the nasal mucosa (HP:0000433)2.24353330
83Chest pain (HP:0100749)2.23211042
84IgG deficiency (HP:0004315)2.22563816
85Increased IgE level (HP:0003212)2.22333662
86Autoimmune hemolytic anemia (HP:0001890)2.22062714
87Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.21971887
88Hemoptysis (HP:0002105)2.21060047
89Restrictive lung disease (HP:0002091)2.18976755
90Amyloidosis (HP:0011034)2.17061153
91Keratoconjunctivitis (HP:0001096)2.16388533
92Abnormality of iron homeostasis (HP:0011031)2.14679489
93Thoracic kyphosis (HP:0002942)2.14652470
94Abnormality of glycolipid metabolism (HP:0010969)2.13455840
95Abnormality of liposaccharide metabolism (HP:0010968)2.13455840
96Abnormality of glycosphingolipid metabolism (HP:0004343)2.13455840
97Hematochezia (HP:0002573)2.13445560
98Sepsis (HP:0100806)2.12783959
99Basal ganglia calcification (HP:0002135)2.12078478
100Abnormality of eosinophils (HP:0001879)2.11364686
101Amaurosis fugax (HP:0100576)2.11002219
102Recurrent sinusitis (HP:0011108)2.10716182
103Keratoconjunctivitis sicca (HP:0001097)2.09258774
104T lymphocytopenia (HP:0005403)2.09053856
105Aplastic anemia (HP:0001915)2.08589619
106Leukopenia (HP:0001882)2.07855015
107Disinhibition (HP:0000734)2.07706908
108Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.06323600
109Hypergammaglobulinemia (HP:0010702)2.06175052
110Neutropenia (HP:0001875)2.06125464
111Abnormality of T cell number (HP:0011839)2.05896273
112Abnormal number of erythroid precursors (HP:0012131)2.05398456
113Chronic sinusitis (HP:0011109)2.04610414
114Urticaria (HP:0001025)2.03728028
115Episodic fever (HP:0001954)2.02527413
116Pulmonary embolism (HP:0002204)2.01762333
117IgA deficiency (HP:0002720)1.99123556
118Urinary glycosaminoglycan excretion (HP:0003541)1.99100620
119Mucopolysacchariduria (HP:0008155)1.99100620
120Hypertensive crisis (HP:0100735)1.98770217
121Lymphoma (HP:0002665)1.98766983
122Premature loss of primary teeth (HP:0006323)1.97822952
123Verrucae (HP:0200043)1.95010646

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.14478732
2PRPF4B3.62409871
3KIT3.30137094
4IRAK43.06560688
5TAOK32.95789769
6BLK2.77174199
7TYK22.61716819
8MAP3K142.42741714
9CSF1R2.29054782
10TBK12.24234319
11BTK2.22030103
12TXK2.15050244
13TEC2.12732900
14RIPK42.07508471
15IKBKE1.95651398
16JAK31.95054812
17IRAK31.93990844
18TGFBR21.90241311
19ZAP701.88706998
20SYK1.88179061
21FES1.81109065
22NEK91.78739595
23IKBKB1.70227144
24ERN11.55868365
25SIK21.53258767
26SMG11.51765631
27PIM21.47224980
28MAP2K31.45100000
29FLT31.41828420
30EEF2K1.41403591
31KDR1.40398111
32CLK11.37359972
33STK101.36783300
34JAK11.36389285
35HCK1.31026710
36LYN1.29296725
37FGR1.28913829
38TRIB31.25392075
39MAP3K31.21307840
40NME21.20417296
41LCK1.19502232
42GRK61.18378307
43SIK31.14949205
44TAOK11.13946585
45MAP3K131.12008286
46SCYL21.09872702
47PIM11.09378400
48RPS6KA41.07177987
49ITK1.06629393
50CDK121.05844247
51PKN21.03704202
52MAP3K11.03088452
53TGFBR11.03071211
54LRRK21.02549528
55CSK1.01881439
56BMPR21.01086385
57CHUK1.00345551
58STK40.99540207
59MATK0.94902008
60MAPK120.92405746
61EPHB10.92231888
62TAOK20.90020649
63MAP3K100.89134363
64GRK70.76286182
65CDC42BPA0.75276793
66MAPK70.74302011
67MARK20.74114076
68JAK20.72256214
69TNK20.71672070
70STK160.71603792
71PDPK10.68212373
72NLK0.66723912
73ATR0.64883536
74VRK10.62969718
75RPS6KA60.62818472
76NEK20.62262739
77YES10.62033931
78IRAK20.61400648
79CDK40.60794934
80MAP2K60.60644626
81MOS0.54104791
82MAPK40.53324764
83PAK40.52916547
84MAPK110.52877143
85TRPM70.52388234
86ADRBK20.51939456
87DYRK30.51646361
88MARK30.51461085
89RPS6KL10.50975043
90RPS6KC10.50975043
91MAP3K60.50064188
92EIF2AK30.49837485
93EIF2AK20.48581304
94KSR20.48561234
95PDK10.48125760
96FGFR40.47524262
97PRKD20.47501355
98FGFR30.47378377
99PIK3CG0.47017321
100ICK0.46429420
101CDK60.45692865
102MAP3K80.45200858
103TIE10.45117467
104HIPK20.44510767
105MAPKAPK20.43701538
106PASK0.42227046
107MAP3K110.41616531
108WEE10.40744169
109MAP3K120.40066763
110PRKCD0.39547071
111CDK70.39247502
112RPS6KB20.38716403
113CCNB10.37944445
114ABL10.36701412
115RPS6KA20.36667541
116FYN0.35952215
117IRAK10.34633002
118MAP3K70.34594554
119CAMK1D0.34541377
120SIK10.34323396
121MAP3K50.34083983
122PRKCQ0.33877792
123ACVR1B0.33789900
124ARAF0.33399367
125TESK20.33262286
126CDK90.32487671
127CDC70.31922287
128MAP2K20.29658739
129CDK190.29580559
130RAF10.28891591
131MAPK30.28721333

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.28493906
2Leishmaniasis_Homo sapiens_hsa051402.82006816
3Antigen processing and presentation_Homo sapiens_hsa046122.47638283
4B cell receptor signaling pathway_Homo sapiens_hsa046622.44725862
5DNA replication_Homo sapiens_hsa030302.35951215
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.32199547
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.27091030
8Osteoclast differentiation_Homo sapiens_hsa043802.21969826
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.17908988
10Other glycan degradation_Homo sapiens_hsa005112.15810846
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.14304201
12Measles_Homo sapiens_hsa051622.11996761
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.96025510
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.95306701
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.86514846
16Hematopoietic cell lineage_Homo sapiens_hsa046401.86011306
17Staphylococcus aureus infection_Homo sapiens_hsa051501.85484185
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.84353266
19Pertussis_Homo sapiens_hsa051331.82411962
20Herpes simplex infection_Homo sapiens_hsa051681.79001778
21Tuberculosis_Homo sapiens_hsa051521.75857079
22Legionellosis_Homo sapiens_hsa051341.67025739
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.61531710
24Influenza A_Homo sapiens_hsa051641.59841808
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.58165878
26Malaria_Homo sapiens_hsa051441.57125183
27Base excision repair_Homo sapiens_hsa034101.55945361
28Allograft rejection_Homo sapiens_hsa053301.55526178
29Toxoplasmosis_Homo sapiens_hsa051451.54428504
30Lysosome_Homo sapiens_hsa041421.49277028
31Mismatch repair_Homo sapiens_hsa034301.42470836
32Shigellosis_Homo sapiens_hsa051311.41861694
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40105471
34Graft-versus-host disease_Homo sapiens_hsa053321.39818369
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.39575492
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37175963
37Ribosome_Homo sapiens_hsa030101.36968973
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33564335
39Apoptosis_Homo sapiens_hsa042101.32386085
40Non-homologous end-joining_Homo sapiens_hsa034501.29873462
41Chemokine signaling pathway_Homo sapiens_hsa040621.22598467
42Homologous recombination_Homo sapiens_hsa034401.22587440
43Acute myeloid leukemia_Homo sapiens_hsa052211.21514055
44T cell receptor signaling pathway_Homo sapiens_hsa046601.21441156
45Hepatitis B_Homo sapiens_hsa051611.19726828
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16819101
47Asthma_Homo sapiens_hsa053101.16095937
48TNF signaling pathway_Homo sapiens_hsa046681.09238671
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05351313
50Leukocyte transendothelial migration_Homo sapiens_hsa046701.04964872
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04195078
52Salmonella infection_Homo sapiens_hsa051321.02534477
53Platelet activation_Homo sapiens_hsa046111.01083712
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96864795
55Epstein-Barr virus infection_Homo sapiens_hsa051690.96180626
56Chronic myeloid leukemia_Homo sapiens_hsa052200.94958251
57Viral myocarditis_Homo sapiens_hsa054160.92511008
58African trypanosomiasis_Homo sapiens_hsa051430.86771535
59Spliceosome_Homo sapiens_hsa030400.86596679
60Phagosome_Homo sapiens_hsa041450.85632453
61Rheumatoid arthritis_Homo sapiens_hsa053230.79723773
62Viral carcinogenesis_Homo sapiens_hsa052030.79627115
63Hepatitis C_Homo sapiens_hsa051600.79359007
64Pancreatic cancer_Homo sapiens_hsa052120.76792252
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76272319
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73994492
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72843382
68Nucleotide excision repair_Homo sapiens_hsa034200.72557898
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71654603
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.68923689
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66140799
72Pyrimidine metabolism_Homo sapiens_hsa002400.65554308
73HTLV-I infection_Homo sapiens_hsa051660.63889695
74Non-small cell lung cancer_Homo sapiens_hsa052230.63516800
75Proteasome_Homo sapiens_hsa030500.62191973
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61481890
77Systemic lupus erythematosus_Homo sapiens_hsa053220.60753972
78Fanconi anemia pathway_Homo sapiens_hsa034600.58109682
79Autoimmune thyroid disease_Homo sapiens_hsa053200.56599427
80Renal cell carcinoma_Homo sapiens_hsa052110.56040064
81RNA polymerase_Homo sapiens_hsa030200.55339322
82p53 signaling pathway_Homo sapiens_hsa041150.55249048
83Bladder cancer_Homo sapiens_hsa052190.54858292
84Cell cycle_Homo sapiens_hsa041100.53895467
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51695400
86RNA degradation_Homo sapiens_hsa030180.50718830
87N-Glycan biosynthesis_Homo sapiens_hsa005100.50301292
88Type I diabetes mellitus_Homo sapiens_hsa049400.49476795
89Caffeine metabolism_Homo sapiens_hsa002320.46929316
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.46897378
91Colorectal cancer_Homo sapiens_hsa052100.44806540
92Pentose phosphate pathway_Homo sapiens_hsa000300.44331748
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.44280805
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43975213
95Small cell lung cancer_Homo sapiens_hsa052220.43640271
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42943448
97Endocytosis_Homo sapiens_hsa041440.42193156
98mTOR signaling pathway_Homo sapiens_hsa041500.42190565
99Amoebiasis_Homo sapiens_hsa051460.42121318
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39999059
101Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.39726165
102GnRH signaling pathway_Homo sapiens_hsa049120.39141742
103Prolactin signaling pathway_Homo sapiens_hsa049170.38862638
104VEGF signaling pathway_Homo sapiens_hsa043700.38791831
105Notch signaling pathway_Homo sapiens_hsa043300.37465050
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34388625
107HIF-1 signaling pathway_Homo sapiens_hsa040660.34370454
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33345248
109Endometrial cancer_Homo sapiens_hsa052130.33237688
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32976068
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32660439
112Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32607755
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.32141285
114One carbon pool by folate_Homo sapiens_hsa006700.31578025
115Insulin resistance_Homo sapiens_hsa049310.31384016
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31136819
117Renin-angiotensin system_Homo sapiens_hsa046140.30436417
118MAPK signaling pathway_Homo sapiens_hsa040100.30152513
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28538749
120Choline metabolism in cancer_Homo sapiens_hsa052310.28530247
121Type II diabetes mellitus_Homo sapiens_hsa049300.27501067
122Collecting duct acid secretion_Homo sapiens_hsa049660.27427915
123Prostate cancer_Homo sapiens_hsa052150.26454865
124FoxO signaling pathway_Homo sapiens_hsa040680.26125693
125Inositol phosphate metabolism_Homo sapiens_hsa005620.25624075
126Prion diseases_Homo sapiens_hsa050200.24818742
127Dorso-ventral axis formation_Homo sapiens_hsa043200.24305059

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