NRTN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)5.36946677
2response to misfolded protein (GO:0051788)5.00083629
3ribosomal small subunit assembly (GO:0000028)4.88247316
4regulation of plasminogen activation (GO:0010755)4.72982796
5viral transcription (GO:0019083)4.59204509
6bundle of His cell to Purkinje myocyte communication (GO:0086069)4.57552709
7oxidative phosphorylation (GO:0006119)4.57206646
8translational termination (GO:0006415)4.42715213
9regulation of mitochondrial translation (GO:0070129)4.40778561
10protein retention in ER lumen (GO:0006621)4.35766073
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.35719225
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.31462565
13protein targeting to ER (GO:0045047)4.21303649
14desmosome organization (GO:0002934)4.18091111
15maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.17713950
16regulation of fibrinolysis (GO:0051917)4.15395353
17cotranslational protein targeting to membrane (GO:0006613)4.15332724
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.04617746
19sarcomere organization (GO:0045214)4.02883561
20translational elongation (GO:0006414)4.00129216
21regulation of gene silencing by miRNA (GO:0060964)3.98332012
22regulation of gene silencing by RNA (GO:0060966)3.98332012
23regulation of posttranscriptional gene silencing (GO:0060147)3.98332012
24ventricular cardiac muscle cell action potential (GO:0086005)3.87613700
25protein localization to endoplasmic reticulum (GO:0070972)3.86638884
26ATP synthesis coupled proton transport (GO:0015986)3.81638595
27energy coupled proton transport, down electrochemical gradient (GO:0015985)3.81638595
28blood coagulation, intrinsic pathway (GO:0007597)3.78850599
29peptidyl-glutamic acid carboxylation (GO:0017187)3.72963594
30protein carboxylation (GO:0018214)3.72963594
31establishment of apical/basal cell polarity (GO:0035089)3.69803173
32folic acid-containing compound biosynthetic process (GO:0009396)3.69704517
33maturation of SSU-rRNA (GO:0030490)3.67339795
34negative regulation of potassium ion transmembrane transport (GO:1901380)3.66297941
35DNA deamination (GO:0045006)3.63311608
36respiratory electron transport chain (GO:0022904)3.62348733
37proline metabolic process (GO:0006560)3.60081919
38tricarboxylic acid cycle (GO:0006099)3.56873589
39electron transport chain (GO:0022900)3.56231088
40ncRNA 3-end processing (GO:0043628)3.53600509
41GDP-mannose metabolic process (GO:0019673)3.52901701
42ribosomal small subunit biogenesis (GO:0042274)3.52625679
43protein autoprocessing (GO:0016540)3.48858299
44regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.45826813
45ribosomal large subunit biogenesis (GO:0042273)3.43881899
46heterochromatin organization (GO:0070828)3.41613414
47hemidesmosome assembly (GO:0031581)3.40469571
48DNA unwinding involved in DNA replication (GO:0006268)3.39711388
49translational initiation (GO:0006413)3.39632578
50planar cell polarity pathway involved in neural tube closure (GO:0090179)3.38415841
51COPI coating of Golgi vesicle (GO:0048205)3.38225990
52Golgi transport vesicle coating (GO:0048200)3.38225990
53regulation of cholesterol biosynthetic process (GO:0045540)3.36962727
54cardiac myofibril assembly (GO:0055003)3.36121725
55viral life cycle (GO:0019058)3.35373004
56nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.33184072
57mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.32169259
584-hydroxyproline metabolic process (GO:0019471)3.27615731
59cardiac muscle cell development (GO:0055013)3.26190722
60cellular protein complex disassembly (GO:0043624)3.25167783
61fibrinolysis (GO:0042730)3.23910459
62negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.23367298
63protein maturation by protein folding (GO:0022417)3.21961390
64polarized epithelial cell differentiation (GO:0030859)3.21288460
65pteridine-containing compound biosynthetic process (GO:0042559)3.17945870
66regulation of mammary gland epithelial cell proliferation (GO:0033599)3.15225242
67erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.14301336
68L-phenylalanine metabolic process (GO:0006558)3.14301336
69cardiac muscle contraction (GO:0060048)3.07083541
70cardiac cell development (GO:0055006)3.06903831
71exocrine pancreas development (GO:0031017)3.06013503
72convergent extension (GO:0060026)3.05246652
73regulation of translational fidelity (GO:0006450)3.03713204
74growth hormone secretion (GO:0030252)3.00241686
75mitotic chromosome condensation (GO:0007076)2.98246030
76regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.97736875
77establishment or maintenance of monopolar cell polarity (GO:0061339)2.95183021
78establishment of monopolar cell polarity (GO:0061162)2.95183021
79intestinal epithelial cell development (GO:0060576)2.95176096
80protein complex disassembly (GO:0043241)2.93767744
81embryonic skeletal joint morphogenesis (GO:0060272)2.90916431
82negative regulation of DNA-templated transcription, elongation (GO:0032785)2.90548295
83negative regulation of fibrinolysis (GO:0051918)2.88991129
84protein targeting to membrane (GO:0006612)2.88293000
85NADH metabolic process (GO:0006734)2.88117035
86endocrine pancreas development (GO:0031018)2.87244445
87apoptotic process involved in morphogenesis (GO:0060561)2.86330181
88plasma lipoprotein particle assembly (GO:0034377)2.85955556
89peptidyl-arginine omega-N-methylation (GO:0035247)2.85876175
90heart trabecula formation (GO:0060347)2.85631631
91membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.84511109
92respiratory chain complex IV assembly (GO:0008535)2.80833621
93peptidyl-proline hydroxylation (GO:0019511)2.79699831
94macromolecular complex disassembly (GO:0032984)2.79121021
95potassium ion export (GO:0071435)2.78425566
96very-low-density lipoprotein particle assembly (GO:0034379)2.78411724
97translation (GO:0006412)2.77582548
98ventricular cardiac muscle cell development (GO:0055015)2.76132634
99L-serine metabolic process (GO:0006563)2.76081101
100myofibril assembly (GO:0030239)2.75520744
101basement membrane organization (GO:0071711)2.75357812
102erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.73617471
103L-phenylalanine catabolic process (GO:0006559)2.73617471
104formation of translation preinitiation complex (GO:0001731)2.72824560
105negative regulation of gene silencing (GO:0060969)2.72306079
106cell-cell junction maintenance (GO:0045217)2.71901473
107maternal placenta development (GO:0001893)2.71584700
108cytidine metabolic process (GO:0046087)2.71194107
109cytidine catabolic process (GO:0006216)2.71194107
110cytidine deamination (GO:0009972)2.71194107
111regulation of apoptotic cell clearance (GO:2000425)2.70143023
112fatty acid homeostasis (GO:0055089)2.70102368
113IMP biosynthetic process (GO:0006188)2.70089752
114regulation of apoptotic process involved in morphogenesis (GO:1902337)2.70084026
115glucose 6-phosphate metabolic process (GO:0051156)2.69973656
116regulation of cardioblast differentiation (GO:0051890)2.69748007
117atrioventricular valve morphogenesis (GO:0003181)2.68917731
118regulation of cholesterol metabolic process (GO:0090181)2.67821552
119ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.67693092
120atrial septum morphogenesis (GO:0060413)2.67603336
121pyrimidine ribonucleoside catabolic process (GO:0046133)2.66881797
122negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.66605563
123tricarboxylic acid metabolic process (GO:0072350)2.66487695
124negative regulation of catenin import into nucleus (GO:0035414)2.65387687
125nucleosome disassembly (GO:0006337)2.65208299
126protein-DNA complex disassembly (GO:0032986)2.65208299
127mitotic G1 DNA damage checkpoint (GO:0031571)2.63569627
128negative regulation of glial cell proliferation (GO:0060253)2.63493833
129cochlea morphogenesis (GO:0090103)2.60909505
130mitochondrial DNA metabolic process (GO:0032042)2.60494838
131negative regulation of myotube differentiation (GO:0010832)2.60380987
132negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.60235829
133DNA strand elongation involved in DNA replication (GO:0006271)2.59663281
134endocardial cushion development (GO:0003197)2.59299140
135epithelial cell fate commitment (GO:0072148)2.58643058
136cardiovascular system development (GO:0072358)2.57580069
137glandular epithelial cell differentiation (GO:0002067)2.57552883
138oxaloacetate metabolic process (GO:0006107)2.56258492
139plasma membrane repair (GO:0001778)2.55710151
140regulation of translational termination (GO:0006449)2.55229517
141serine family amino acid biosynthetic process (GO:0009070)2.55178422
142positive regulation of SMAD protein import into nucleus (GO:0060391)2.53456311
143regulation of proton transport (GO:0010155)2.53124731
144protein-lipid complex assembly (GO:0065005)2.52388451
145post-embryonic morphogenesis (GO:0009886)2.52328688
146cell junction maintenance (GO:0034331)2.51915209
147Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.51693692
148cardiac muscle tissue morphogenesis (GO:0055008)2.51550757
149galactose catabolic process (GO:0019388)2.51420768
150regulation of cholesterol esterification (GO:0010872)2.50841747
151membrane repolarization during action potential (GO:0086011)2.50304094
152cholesterol catabolic process (GO:0006707)2.49906937
153sterol catabolic process (GO:0016127)2.49906937
154activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.49594804
155muscle organ morphogenesis (GO:0048644)2.49515807
156regulation of protein activation cascade (GO:2000257)2.49487138
157apoptotic process involved in development (GO:1902742)2.48549112
158DNA strand elongation (GO:0022616)2.48169255
159chromatin assembly (GO:0031497)2.46773195
160regulation of glucose import in response to insulin stimulus (GO:2001273)2.46534543
161DNA replication initiation (GO:0006270)2.44708495
162protein insertion into membrane (GO:0051205)2.43127683
163pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.41119759
164outflow tract septum morphogenesis (GO:0003148)2.40970289
165regulation of cholesterol homeostasis (GO:2000188)2.40801322
166gluconeogenesis (GO:0006094)2.40349320
167regulation of complement activation (GO:0030449)2.40172653
168glycine metabolic process (GO:0006544)2.39821697
169pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.37864586
170homocysteine metabolic process (GO:0050667)2.37051295
171negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.36353897
172lung epithelium development (GO:0060428)2.35488587
173retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.35333552

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.59740394
2E2F7_22180533_ChIP-Seq_HELA_Human3.59257396
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.41117501
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.23029889
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.92813355
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.45963306
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.21692364
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.21692364
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.21692364
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.11314344
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.10535406
12ZNF263_19887448_ChIP-Seq_K562_Human1.94091015
13TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93359880
14ESR1_15608294_ChIP-ChIP_MCF-7_Human1.92262579
15MYC_19030024_ChIP-ChIP_MESCs_Mouse1.87341552
16POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.87310741
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.85186376
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78520625
19DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.71620966
20NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.71254378
21ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.69945154
22* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.67380886
23ERG_21242973_ChIP-ChIP_JURKAT_Human1.66277906
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.66077253
25E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63574061
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62483226
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.62423236
28NANOG_18555785_ChIP-Seq_MESCs_Mouse1.61098650
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.60689752
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59597388
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.58096642
32SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.57532808
33LXR_22292898_ChIP-Seq_THP-1_Human1.57419364
34RACK7_27058665_Chip-Seq_MCF-7_Human1.53688563
35* XRN2_22483619_ChIP-Seq_HELA_Human1.52742225
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51210148
37ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49276331
38KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.49236364
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.47009575
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.46222718
41SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.44858023
42MYC_22102868_ChIP-Seq_BL_Human1.43928334
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.42444414
44CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.42421855
45RXR_22158963_ChIP-Seq_LIVER_Mouse1.41815926
46* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.41757148
47ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.40953506
48* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38481839
49ATF3_27146783_Chip-Seq_COLON_Human1.37242491
50TCF3_18692474_ChIP-Seq_MEFs_Mouse1.36704428
51KDM2B_26808549_Chip-Seq_K562_Human1.35933322
52BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.35756642
53CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34987428
54ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.34676512
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.32967864
56VDR_21846776_ChIP-Seq_THP-1_Human1.31147882
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.30506227
58FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.29680745
59DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29272999
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27648074
61* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27135489
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26994997
63* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25686283
64* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25429797
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25285211
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23639614
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23541630
68* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22743853
69* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.22620200
70HIF1A_21447827_ChIP-Seq_MCF-7_Human1.22471121
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22215401
72OCT4_18692474_ChIP-Seq_MEFs_Mouse1.21948730
73CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.21648095
74SA1_27219007_Chip-Seq_ERYTHROID_Human1.20875598
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20060462
76DCP1A_22483619_ChIP-Seq_HELA_Human1.19663035
77GABP_17652178_ChIP-ChIP_JURKAT_Human1.18980485
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18391984
79SMC4_20622854_ChIP-Seq_HELA_Human1.17793455
80YY1_22570637_ChIP-Seq_MALME-3M_Human1.17730666
81UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17287363
82P68_20966046_ChIP-Seq_HELA_Human1.16046318
83NANOG_21062744_ChIP-ChIP_HESCs_Human1.15865251
84* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15732376
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15226236
86TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14523915
87* CTCF_27219007_Chip-Seq_Bcells_Human1.14382762
88SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14324765
89PPARA_22158963_ChIP-Seq_LIVER_Mouse1.14018669
90* KDM2B_26808549_Chip-Seq_DND41_Human1.13410454
91TET1_21451524_ChIP-Seq_MESCs_Mouse1.12965815
92THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12722836
93SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.12713738
94CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12289192
95* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11666783
96* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11025631
97RARA_24833708_ChIP-Seq_LIVER_Mouse1.10792805
98TBX5_21415370_ChIP-Seq_HL-1_Mouse1.10579086
99AR_21909140_ChIP-Seq_LNCAP_Human1.10451892
100YY1_21170310_ChIP-Seq_MESCs_Mouse1.09980055
101* TTF2_22483619_ChIP-Seq_HELA_Human1.09825590
102* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07789079
103ELK3_25401928_ChIP-Seq_HUVEC_Human1.07482693
104STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06659871
105MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.06347367
106CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.06150974
107* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05758369
108KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05427447
109NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04697772
110ESR2_21235772_ChIP-Seq_MCF-7_Human1.04480971
111* NCOR1_26117541_ChIP-Seq_K562_Human1.04108587
112RARB_24833708_ChIP-Seq_LIVER_Mouse1.03915285
113PHF8_20622854_ChIP-Seq_HELA_Human1.03391131
114CTCF_21964334_Chip-Seq_Bcells_Human1.02749147
115PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02214987
116TCF7_22412390_ChIP-Seq_EML_Mouse1.02008767
117* FOXP1_21924763_ChIP-Seq_HESCs_Human1.01943131
118CIITA_25753668_ChIP-Seq_RAJI_Human1.01418314
119RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00977613
120PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.00755572
121BCOR_27268052_Chip-Seq_Bcells_Human1.00110951
122GABP_19822575_ChIP-Seq_HepG2_Human0.99563976
123ELF1_20517297_ChIP-Seq_JURKAT_Human0.98796933
124HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98156001
125SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97793855
126SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97752754
127GATA6_25053715_ChIP-Seq_YYC3_Human0.97266848
128ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.96663487
129P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96559921
130SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95753885
131POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95431754
132* CREB1_26743006_Chip-Seq_LNCaP_Human0.95072422
133E2F1_21310950_ChIP-Seq_MCF-7_Human0.94473982
134RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93961601
135CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93664191

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.06353059
2MP0000566_synostosis3.87009803
3MP0004084_abnormal_cardiac_muscle3.15919128
4MP0005451_abnormal_body_composition3.07742533
5MP0003646_muscle_fatigue2.69504794
6MP0000751_myopathy2.68493155
7MP0004215_abnormal_myocardial_fiber2.65300487
8MP0005330_cardiomyopathy2.63728560
9MP0005360_urolithiasis2.57142420
10MP0003283_abnormal_digestive_organ2.56621817
11MP0003123_paternal_imprinting2.52788437
12MP0000678_abnormal_parathyroid_gland2.48782921
13MP0003705_abnormal_hypodermis_morpholog2.32641130
14MP0002089_abnormal_postnatal_growth/wei2.27804913
15MP0002163_abnormal_gland_morphology2.27210821
16MP0002877_abnormal_melanocyte_morpholog2.18810598
17MP0004858_abnormal_nervous_system2.15236941
18MP0005257_abnormal_intraocular_pressure2.15030635
19MP0003111_abnormal_nucleus_morphology2.11488035
20MP0006036_abnormal_mitochondrial_physio2.06265998
21MP0004036_abnormal_muscle_relaxation2.05487851
22MP0000750_abnormal_muscle_regeneration2.00652299
23MP0003137_abnormal_impulse_conducting1.97905356
24MP0004043_abnormal_pH_regulation1.96692215
25MP0003806_abnormal_nucleotide_metabolis1.95648688
26MP0002249_abnormal_larynx_morphology1.92954914
27MP0003941_abnormal_skin_development1.82879418
28MP0005171_absent_coat_pigmentation1.80291551
29MP0000749_muscle_degeneration1.79926589
30MP0002234_abnormal_pharynx_morphology1.79884208
31MP0008932_abnormal_embryonic_tissue1.78036115
32MP0004087_abnormal_muscle_fiber1.75997180
33MP0005058_abnormal_lysosome_morphology1.72403829
34MP0000579_abnormal_nail_morphology1.70426469
35MP0010030_abnormal_orbit_morphology1.69430992
36MP0005220_abnormal_exocrine_pancreas1.68957276
37MP0004957_abnormal_blastocyst_morpholog1.66870468
38MP0010630_abnormal_cardiac_muscle1.66852717
39MP0002269_muscular_atrophy1.66041415
40MP0004133_heterotaxia1.65648599
41MP0001849_ear_inflammation1.64043774
42MP0002139_abnormal_hepatobiliary_system1.63356581
43MP0003119_abnormal_digestive_system1.59324509
44MP0003942_abnormal_urinary_system1.56925543
45MP0010094_abnormal_chromosome_stability1.53843287
46MP0009384_cardiac_valve_regurgitation1.51766208
47MP0005083_abnormal_biliary_tract1.50932087
48MP0002972_abnormal_cardiac_muscle1.50756466
49MP0001346_abnormal_lacrimal_gland1.50722772
50MP0004264_abnormal_extraembryonic_tissu1.47117646
51MP0002796_impaired_skin_barrier1.44107868
52MP0009379_abnormal_foot_pigmentation1.41127066
53MP0004272_abnormal_basement_membrane1.39948812
54MP0005670_abnormal_white_adipose1.39145195
55MP0003566_abnormal_cell_adhesion1.38777301
56MP0006138_congestive_heart_failure1.38207498
57MP0009840_abnormal_foam_cell1.38092092
58MP0005408_hypopigmentation1.37501903
59MP0005385_cardiovascular_system_phenoty1.37426634
60MP0001544_abnormal_cardiovascular_syste1.37426634
61MP0003221_abnormal_cardiomyocyte_apopto1.36076390
62MP0002693_abnormal_pancreas_physiology1.36064548
63MP0003077_abnormal_cell_cycle1.35201803
64MP0001661_extended_life_span1.32433661
65MP0001944_abnormal_pancreas_morphology1.31407521
66MP0006072_abnormal_retinal_apoptosis1.30598011
67MP0008775_abnormal_heart_ventricle1.30182423
68MP0003385_abnormal_body_wall1.28715429
69MP0001727_abnormal_embryo_implantation1.23937345
70MP0000516_abnormal_urinary_system1.23567923
71MP0005367_renal/urinary_system_phenotyp1.23567923
72MP0010352_gastrointestinal_tract_polyps1.23336987
73MP0003315_abnormal_perineum_morphology1.23222641
74MP0003693_abnormal_embryo_hatching1.21681162
75MP0000462_abnormal_digestive_system1.19262252
76MP0003567_abnormal_fetal_cardiomyocyte1.19020136
77MP0002098_abnormal_vibrissa_morphology1.18327406
78MP0002106_abnormal_muscle_physiology1.15477986
79MP0008789_abnormal_olfactory_epithelium1.15206365
80MP0005365_abnormal_bile_salt1.14895265
81MP0000372_irregular_coat_pigmentation1.14244808
82MP0008007_abnormal_cellular_replicative1.14194733
83MP0000350_abnormal_cell_proliferation1.12845345
84MP0004185_abnormal_adipocyte_glucose1.12622910
85MP0000013_abnormal_adipose_tissue1.12169114
86* MP0005620_abnormal_muscle_contractility1.11888003
87MP0005379_endocrine/exocrine_gland_phen1.11641197
88MP0009643_abnormal_urine_homeostasis1.11275311
89MP0001666_abnormal_nutrient_absorption1.10344742
90MP0000762_abnormal_tongue_morphology1.09959055
91MP0002909_abnormal_adrenal_gland1.07416765
92MP0005666_abnormal_adipose_tissue1.06885982
93MP0002080_prenatal_lethality1.06653083
94MP0005501_abnormal_skin_physiology1.05988340
95MP0003828_pulmonary_edema1.05794239
96MP0005076_abnormal_cell_differentiation1.05563068
97MP0009672_abnormal_birth_weight1.04954089
98MP0000759_abnormal_skeletal_muscle1.04801063
99MP0008260_abnormal_autophagy1.04768739
100MP0000537_abnormal_urethra_morphology1.01351387
101MP0003868_abnormal_feces_composition0.98625499
102MP0004233_abnormal_muscle_weight0.97187515
103MP0002127_abnormal_cardiovascular_syste0.96423779
104MP0000266_abnormal_heart_morphology0.95320737
105MP0003136_yellow_coat_color0.94572599
106MP0009697_abnormal_copulation0.93097555
107MP0002653_abnormal_ependyma_morphology0.92190558
108MP0005375_adipose_tissue_phenotype0.92174657
109MP0000613_abnormal_salivary_gland0.91973202
110MP0002697_abnormal_eye_size0.91149748
111MP0002060_abnormal_skin_morphology0.90645372
112MP0003937_abnormal_limbs/digits/tail_de0.89179928
113MP0004085_abnormal_heartbeat0.89163809
114MP0005377_hearing/vestibular/ear_phenot0.89033839
115MP0003878_abnormal_ear_physiology0.89033839
116MP0005369_muscle_phenotype0.87743491
117MP0004130_abnormal_muscle_cell0.86855111
118MP0003195_calcinosis0.86528426
119MP0002085_abnormal_embryonic_tissue0.86236089
120MP0004197_abnormal_fetal_growth/weight/0.85818526
121MP0000003_abnormal_adipose_tissue0.85774686
122MP0001270_distended_abdomen0.84343234
123MP0003115_abnormal_respiratory_system0.82965390
124MP0005275_abnormal_skin_tensile0.82826932
125MP0001697_abnormal_embryo_size0.82662694
126MP0003984_embryonic_growth_retardation0.82400183
127MP0004145_abnormal_muscle_electrophysio0.82151297
128MP0002088_abnormal_embryonic_growth/wei0.82050921
129MP0006035_abnormal_mitochondrial_morpho0.81963093
130* MP0002092_abnormal_eye_morphology0.81805563
131MP0002084_abnormal_developmental_patter0.81536673
132MP0000747_muscle_weakness0.81443084
133MP0005380_embryogenesis_phenotype0.80791063
134MP0001672_abnormal_embryogenesis/_devel0.80791063
135MP0000467_abnormal_esophagus_morphology0.80541391
136MP0002254_reproductive_system_inflammat0.80054427
137MP0005499_abnormal_olfactory_system0.79672465
138MP0005394_taste/olfaction_phenotype0.79672465
139MP0001730_embryonic_growth_arrest0.79605067
140MP0000534_abnormal_ureter_morphology0.79208722
141MP0002111_abnormal_tail_morphology0.79126013
142MP0000681_abnormal_thyroid_gland0.78415675
143MP0003122_maternal_imprinting0.77969867
144MP0002078_abnormal_glucose_homeostasis0.77604104
145MP0000049_abnormal_middle_ear0.77455934
146MP0009053_abnormal_anal_canal0.76456469
147MP0001915_intracranial_hemorrhage0.75300942
148MP0002086_abnormal_extraembryonic_tissu0.72545545
149MP0002233_abnormal_nose_morphology0.70949770
150MP0005409_darkened_coat_color0.70917296

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)4.86805777
2Ventricular fibrillation (HP:0001663)4.72117021
3Deep venous thrombosis (HP:0002625)4.70049987
4Sudden death (HP:0001699)4.35151063
5Ventricular tachycardia (HP:0004756)4.34404800
6Testicular atrophy (HP:0000029)4.26139813
7Right ventricular cardiomyopathy (HP:0011663)4.03720516
8Truncus arteriosus (HP:0001660)3.97794837
9Ketoacidosis (HP:0001993)3.52633275
10Congenital malformation of the right heart (HP:0011723)3.52331220
11Double outlet right ventricle (HP:0001719)3.52331220
12Palpitations (HP:0001962)3.51776053
13Hypoglycemic coma (HP:0001325)3.40193790
14Hepatic necrosis (HP:0002605)3.26967256
15Myoglobinuria (HP:0002913)3.24341388
16Syncope (HP:0001279)3.14852316
17Abnormality of the intrinsic pathway (HP:0010989)3.07578717
18Hyperinsulinemic hypoglycemia (HP:0000825)3.06073886
19Rectal prolapse (HP:0002035)3.05325488
20Ventricular arrhythmia (HP:0004308)2.96822657
21Late onset (HP:0003584)2.93571654
22Transposition of the great arteries (HP:0001669)2.90106505
23Abnormal connection of the cardiac segments (HP:0011545)2.90106505
24Abnormal ventriculo-arterial connection (HP:0011563)2.90106505
25Prolonged QT interval (HP:0001657)2.89648820
26Progressive muscle weakness (HP:0003323)2.87396510
27Hepatocellular necrosis (HP:0001404)2.83414605
28Ulnar bowing (HP:0003031)2.79818829
29Exercise-induced muscle cramps (HP:0003710)2.79449156
30Abnormal mitochondria in muscle tissue (HP:0008316)2.75721415
31Oral leukoplakia (HP:0002745)2.75357026
32Acute encephalopathy (HP:0006846)2.74539577
33Atrial fibrillation (HP:0005110)2.74280619
34Acute necrotizing encephalopathy (HP:0006965)2.70457979
35Increased connective tissue (HP:0009025)2.69453713
36Abnormality of aromatic amino acid family metabolism (HP:0004338)2.68709569
37Hyperthyroidism (HP:0000836)2.64707362
38Lipoatrophy (HP:0100578)2.63337915
39Supraventricular arrhythmia (HP:0005115)2.62727735
40Asymmetric septal hypertrophy (HP:0001670)2.61998804
41Supraventricular tachycardia (HP:0004755)2.58305891
42Abnormality of the tricuspid valve (HP:0001702)2.57723379
43Primary atrial arrhythmia (HP:0001692)2.56217116
44Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.55443739
45Abnormality of cells of the erythroid lineage (HP:0012130)2.54720003
46Abnormal tarsal ossification (HP:0008369)2.49564965
47Abnormal EKG (HP:0003115)2.49478401
48Muscle fiber splitting (HP:0003555)2.49395254
49Premature skin wrinkling (HP:0100678)2.48123390
50Dilated cardiomyopathy (HP:0001644)2.48069023
51Abnormality of the left ventricular outflow tract (HP:0011103)2.46580805
52Subaortic stenosis (HP:0001682)2.46580805
53Ketosis (HP:0001946)2.46432971
54Mitochondrial inheritance (HP:0001427)2.45816571
55Abnormal gallbladder physiology (HP:0012438)2.44896541
56Cholecystitis (HP:0001082)2.44896541
57Calf muscle hypertrophy (HP:0008981)2.43321319
58Joint hemorrhage (HP:0005261)2.42394202
59Partial duplication of thumb phalanx (HP:0009944)2.42332614
60Dicarboxylic aciduria (HP:0003215)2.41081772
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.41081772
62Preauricular pit (HP:0004467)2.38106471
63Periauricular skin pits (HP:0100277)2.38106471
64Microretrognathia (HP:0000308)2.37496816
65Abnormality of the Achilles tendon (HP:0005109)2.37288254
66Abnormal hemoglobin (HP:0011902)2.36223368
67Pili torti (HP:0003777)2.36200259
68Posterior subcapsular cataract (HP:0007787)2.35767334
69Bundle branch block (HP:0011710)2.33859594
70Exercise-induced myalgia (HP:0003738)2.32262948
71Generalized aminoaciduria (HP:0002909)2.31524069
72Broad distal phalanx of finger (HP:0009836)2.31367062
73Hypoplastic left heart (HP:0004383)2.31102515
74Missing ribs (HP:0000921)2.30158121
75Multiple enchondromatosis (HP:0005701)2.29179652
76Microvesicular hepatic steatosis (HP:0001414)2.29111582
77Achilles tendon contracture (HP:0001771)2.23663266
78Rhabdomyolysis (HP:0003201)2.23534426
79Trismus (HP:0000211)2.23274312
80Xanthomatosis (HP:0000991)2.22928677
81Decreased activity of mitochondrial respiratory chain (HP:0008972)2.22243170
82Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.22243170
83Fragile skin (HP:0001030)2.21891455
84Adenoma sebaceum (HP:0009720)2.21865665
85Angiofibromas (HP:0010615)2.21865665
86Large for gestational age (HP:0001520)2.21250278
87Milia (HP:0001056)2.20692186
88Increased CSF lactate (HP:0002490)2.19208393
89Increased muscle lipid content (HP:0009058)2.19129855
90Abnormality of the pancreatic islet cells (HP:0006476)2.18296909
91Abnormality of endocrine pancreas physiology (HP:0012093)2.18296909
92Hypercholesterolemia (HP:0003124)2.17135431
93Aplastic anemia (HP:0001915)2.15449841
94Reticulocytopenia (HP:0001896)2.14603575
95Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.14146842
96Short 1st metacarpal (HP:0010034)2.14146842
97Ragged-red muscle fibers (HP:0003200)2.13342106
98Palmoplantar keratoderma (HP:0000982)2.12609955
99Mildly elevated creatine phosphokinase (HP:0008180)2.12511693
100Hyperacusis (HP:0010780)2.12405972
101Difficulty climbing stairs (HP:0003551)2.12082817
102Gout (HP:0001997)2.11588356
103Abnormality of the calf musculature (HP:0001430)2.10385422
104Cerebral edema (HP:0002181)2.08979209
105Disproportionate tall stature (HP:0001519)2.08655891
106Abnormality of the distal phalanges of the toes (HP:0010182)2.08372178
107Conjunctival hamartoma (HP:0100780)2.08010833
108Complement deficiency (HP:0004431)2.07042437
109Absent epiphyses (HP:0010577)2.05317470
110Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.05317470
111Partial duplication of the phalanx of hand (HP:0009999)2.03840058
112Abnormality of complement system (HP:0005339)2.02364299
113Hemorrhage of the eye (HP:0011885)2.02024107
114Alacrima (HP:0000522)2.01574505
115Aplasia/Hypoplasia of the sacrum (HP:0008517)2.01505705
116Abnormal atrioventricular conduction (HP:0005150)2.01497441
117Centrally nucleated skeletal muscle fibers (HP:0003687)2.00885133
118Lymphangioma (HP:0100764)2.00839762
119Increased intramyocellular lipid droplets (HP:0012240)2.00774279
120Heart block (HP:0012722)2.00747294
121Atrioventricular block (HP:0001678)1.98971478
122Hyperglycinuria (HP:0003108)1.98629120
123Symptomatic seizures (HP:0011145)1.98460776
124Pseudobulbar signs (HP:0002200)1.95269492
125Muscle hypertrophy of the lower extremities (HP:0008968)1.95203867
126Abnormal number of erythroid precursors (HP:0012131)1.95003939
127Progressive macrocephaly (HP:0004481)1.94147477
128Hypobetalipoproteinemia (HP:0003563)1.93659527
129Myotonia (HP:0002486)1.93406951
130Reticulocytosis (HP:0001923)1.92166422
131Hyporeflexia of lower limbs (HP:0002600)1.91330343
13211 pairs of ribs (HP:0000878)1.90936471
133Abnormality of the salivary glands (HP:0010286)1.90098835
134Exercise intolerance (HP:0003546)1.89822438
135Vaginal fistula (HP:0004320)1.89048769
136Abnormality of reticulocytes (HP:0004312)1.88200881
137Distal lower limb muscle weakness (HP:0009053)1.87428663
138Hypoglycemic seizures (HP:0002173)1.85870566
139Abnormality of the 1st metacarpal (HP:0010009)1.85833588
140Woolly hair (HP:0002224)1.85657259
141Pancreatic islet-cell hyperplasia (HP:0004510)1.85265995
142Hypercortisolism (HP:0001578)1.84739454
143Respiratory failure (HP:0002878)1.84678312
144Abnormality of the thoracic spine (HP:0100711)1.84624587
145Short phalanx of the thumb (HP:0009660)1.84511423
146Fragile nails (HP:0001808)1.84469298
147Cholelithiasis (HP:0001081)1.83834023
148Anomalous pulmonary venous return (HP:0010772)1.83531015
149Abnormal umbilical cord blood vessels (HP:0011403)1.82426563
150Single umbilical artery (HP:0001195)1.82426563
151Abnormality of the fetal cardiovascular system (HP:0010948)1.82426563
152Upper limb amyotrophy (HP:0009129)1.82320602
153Distal upper limb amyotrophy (HP:0007149)1.82320602
154Diastasis recti (HP:0001540)1.82044784
155Abnormality of the gallbladder (HP:0005264)1.81222474
156Hyperglycemia (HP:0003074)1.81217659
157Mesangial abnormality (HP:0001966)1.79168756
158Rough bone trabeculation (HP:0100670)1.78923194
159Abnormality of carpal bone ossification (HP:0006257)1.78135081
160Bifid scrotum (HP:0000048)1.75985250
161Insomnia (HP:0100785)1.74833557
162Abnormality of monocarboxylic acid metabolism (HP:0010996)1.72787227
163Epiphyseal dysplasia (HP:0002656)1.72350121
164Skin pits (HP:0100276)1.71236454
165Abnormality of the umbilical cord (HP:0010881)1.69406388
166Flat acetabular roof (HP:0003180)1.67312146
167Neonatal hypoglycemia (HP:0001998)1.66684138
168Abnormality of the pulmonary veins (HP:0011718)1.66269340
169Cerebral aneurysm (HP:0004944)1.66003713
170Asymmetry of the thorax (HP:0001555)1.64112962
171Long palpebral fissure (HP:0000637)1.63079322
172Abnormality of the aortic arch (HP:0012303)1.62704097
173Distal lower limb amyotrophy (HP:0008944)1.61464888
174Duplication of thumb phalanx (HP:0009942)1.61088913
175Abnormality of glycolysis (HP:0004366)1.61022563

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.66251824
2TRIB33.39900062
3NME23.31978136
4MAP3K103.08463876
5PKN23.05620183
6MAP2K22.87749585
7ERN12.86486986
8NEK12.69419558
9TTN2.55492748
10NME12.42471735
11FGFR42.41476124
12FLT32.35724394
13SMG12.35357621
14MAPK152.24492212
15RPS6KB22.05078644
16LMTK22.01553892
17IRAK31.98820165
18EPHA21.93272867
19MAPKAPK31.81139427
20INSRR1.78068452
21CDK81.77466715
22WNK41.76046726
23CDC71.75428716
24SCYL21.59361838
25PASK1.58210865
26CDK121.57915504
27TESK21.48898357
28PBK1.47292150
29EIF2AK11.46560262
30TYRO31.45631122
31DYRK1B1.39536710
32BRSK21.38510120
33BRAF1.33896446
34PHKG11.32880427
35PHKG21.32880427
36PRPF4B1.32000965
37MAP3K111.27294371
38PDK31.25604543
39PDK41.25604543
40EPHB21.24380645
41CHEK21.21719151
42MYLK1.16032744
43WEE11.15350186
44HIPK21.09909117
45MET1.09315081
46DYRK31.04356961
47PDGFRA1.03583894
48PLK41.02564339
49NEK21.02443556
50EIF2AK31.02175857
51ARAF1.01852931
52TTK1.01758175
53ACVR1B1.00814915
54EEF2K0.99736698
55PRKD30.96961815
56LRRK20.95178554
57KDR0.93847750
58MST1R0.91128931
59MAP3K30.90955172
60PTK60.89725816
61CAMKK20.87886403
62PRKCI0.85909548
63ILK0.85839642
64DDR20.84912025
65PAK40.80520646
66BUB10.79504607
67TESK10.79291131
68MAP3K80.78910799
69AURKB0.78226635
70CDK70.72221721
71PRKD10.69538110
72ABL20.68437624
73SIK10.68228207
74PIM20.65958823
75ATR0.65453104
76ICK0.65380430
77PRKD20.65208725
78FER0.65172120
79PINK10.64625320
80CAMK40.64232293
81PRKG20.64022736
82LATS20.63730908
83PTK20.63015676
84CDC42BPA0.61904457
85CDK20.61547857
86CSNK1G30.61246039
87CAMK1D0.61191667
88KSR20.60917283
89MAP3K10.60492027
90MTOR0.58296825
91CHEK10.58173667
92PDK20.57751885
93TIE10.56606490
94DMPK0.55789702
95STK38L0.55341111
96RIPK10.54719972
97PLK10.54708210
98MAP3K20.53984396
99AURKA0.53080632
100RPS6KC10.52879534
101RPS6KL10.52879534
102CDK10.52732356
103MAP3K60.52246647
104DAPK30.51596131
105PDPK10.51394558
106PAK30.50666525
107MAPK110.50369733
108TAOK20.50286624
109CSNK1E0.49973360
110MARK30.49481744
111MAP3K70.48765289
112TGFBR10.48297789
113CSNK2A20.47206816
114CDK11A0.46456674
115MAP2K60.46259928
116PAK10.44938666
117CDK150.44572603
118AKT20.44517579
119STK40.44079996
120VRK10.42653653
121TLK10.42375720
122FGFR30.41724208
123RPS6KA10.41644953
124PRKAA10.41453344
125CDK140.41351707
126BCR0.40920878
127RPS6KA60.40781011
128VRK20.40649696
129TGFBR20.40585902
130MAPK120.39976957
131CSNK1A1L0.39375153
132MUSK0.38548315
133BRSK10.37799390
134CDK40.37717357
135CSNK2A10.37209367
136MAP2K30.37013067
137PAK20.36325786
138CDK180.36287693
139ALK0.35767787
140CAMKK10.35714969
141UHMK10.35282609
142BMX0.35012967
143CAMK2D0.31158630

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.35301454
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.04931401
3Ribosome_Homo sapiens_hsa030103.59700790
4Oxidative phosphorylation_Homo sapiens_hsa001903.03165951
5Parkinsons disease_Homo sapiens_hsa050122.96607343
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.71503509
7Cardiac muscle contraction_Homo sapiens_hsa042602.22871654
8Arginine biosynthesis_Homo sapiens_hsa002202.16025432
9Phenylalanine metabolism_Homo sapiens_hsa003602.08463640
10DNA replication_Homo sapiens_hsa030302.08144850
11Alzheimers disease_Homo sapiens_hsa050102.06301182
12Huntingtons disease_Homo sapiens_hsa050162.03642534
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.00933131
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.97972616
15Folate biosynthesis_Homo sapiens_hsa007901.93436460
16Complement and coagulation cascades_Homo sapiens_hsa046101.86756089
17Carbon metabolism_Homo sapiens_hsa012001.83412117
18Protein export_Homo sapiens_hsa030601.82064068
19Fatty acid degradation_Homo sapiens_hsa000711.78099102
20Mismatch repair_Homo sapiens_hsa034301.76939652
21Propanoate metabolism_Homo sapiens_hsa006401.75947390
22Tyrosine metabolism_Homo sapiens_hsa003501.75914959
23Sulfur metabolism_Homo sapiens_hsa009201.57856187
24Biosynthesis of amino acids_Homo sapiens_hsa012301.50450068
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.44158523
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.42708660
27Protein digestion and absorption_Homo sapiens_hsa049741.41378460
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36093400
29Galactose metabolism_Homo sapiens_hsa000521.34999499
30Bladder cancer_Homo sapiens_hsa052191.33587137
31Fat digestion and absorption_Homo sapiens_hsa049751.31779963
32Pyruvate metabolism_Homo sapiens_hsa006201.30721558
33Other glycan degradation_Homo sapiens_hsa005111.26217948
34Vitamin B6 metabolism_Homo sapiens_hsa007501.25284625
35Arginine and proline metabolism_Homo sapiens_hsa003301.20917103
36Pyrimidine metabolism_Homo sapiens_hsa002401.19847676
37Pancreatic secretion_Homo sapiens_hsa049721.19595591
38Thyroid cancer_Homo sapiens_hsa052161.18869902
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18651204
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.17955536
41Prion diseases_Homo sapiens_hsa050201.16614409
42One carbon pool by folate_Homo sapiens_hsa006701.16360604
43Selenocompound metabolism_Homo sapiens_hsa004501.14092385
44Fructose and mannose metabolism_Homo sapiens_hsa000511.09182187
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08934091
46Homologous recombination_Homo sapiens_hsa034401.08829087
47Spliceosome_Homo sapiens_hsa030401.06401219
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.02529794
49Dilated cardiomyopathy_Homo sapiens_hsa054141.01832812
50Base excision repair_Homo sapiens_hsa034100.99512742
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.97212740
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97175669
53Fatty acid biosynthesis_Homo sapiens_hsa000610.94868473
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92806664
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92623143
56N-Glycan biosynthesis_Homo sapiens_hsa005100.92059873
57Lysine degradation_Homo sapiens_hsa003100.87390380
58Tryptophan metabolism_Homo sapiens_hsa003800.85724284
59RNA polymerase_Homo sapiens_hsa030200.82284269
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81700926
61Basal cell carcinoma_Homo sapiens_hsa052170.81545367
62Steroid biosynthesis_Homo sapiens_hsa001000.81258470
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80038764
64RNA transport_Homo sapiens_hsa030130.79391754
65Notch signaling pathway_Homo sapiens_hsa043300.78872251
66Fatty acid metabolism_Homo sapiens_hsa012120.75930750
67Pentose phosphate pathway_Homo sapiens_hsa000300.70406763
68Insulin secretion_Homo sapiens_hsa049110.69317593
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.68722356
70Purine metabolism_Homo sapiens_hsa002300.68332368
71RNA degradation_Homo sapiens_hsa030180.67172058
72Sulfur relay system_Homo sapiens_hsa041220.67009756
73Bile secretion_Homo sapiens_hsa049760.66078041
74Linoleic acid metabolism_Homo sapiens_hsa005910.65443566
75Insulin resistance_Homo sapiens_hsa049310.65376363
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64122501
77mRNA surveillance pathway_Homo sapiens_hsa030150.63665279
78Hedgehog signaling pathway_Homo sapiens_hsa043400.61830270
79Glucagon signaling pathway_Homo sapiens_hsa049220.61665236
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61431596
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60840360
82Nucleotide excision repair_Homo sapiens_hsa034200.60249725
83Metabolic pathways_Homo sapiens_hsa011000.60104165
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.60023073
85beta-Alanine metabolism_Homo sapiens_hsa004100.59658359
86Butanoate metabolism_Homo sapiens_hsa006500.59347944
87Glutathione metabolism_Homo sapiens_hsa004800.58816076
88p53 signaling pathway_Homo sapiens_hsa041150.58049286
89Tight junction_Homo sapiens_hsa045300.54618347
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54174199
91Proteasome_Homo sapiens_hsa030500.53868257
92Arachidonic acid metabolism_Homo sapiens_hsa005900.52929013
93PPAR signaling pathway_Homo sapiens_hsa033200.52130890
94Insulin signaling pathway_Homo sapiens_hsa049100.51716028
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.51635114
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48461111
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48215511
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48107241
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47644898
100Chronic myeloid leukemia_Homo sapiens_hsa052200.47463076
101Cell cycle_Homo sapiens_hsa041100.46567884
102Starch and sucrose metabolism_Homo sapiens_hsa005000.45728103
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44642308
104Small cell lung cancer_Homo sapiens_hsa052220.42435778
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42378875
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41456421
107ECM-receptor interaction_Homo sapiens_hsa045120.41180806
108VEGF signaling pathway_Homo sapiens_hsa043700.40014206
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37576954
110Vibrio cholerae infection_Homo sapiens_hsa051100.36837374
111Vitamin digestion and absorption_Homo sapiens_hsa049770.34976768
112Hippo signaling pathway_Homo sapiens_hsa043900.34374571
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33566715
114Non-small cell lung cancer_Homo sapiens_hsa052230.33409550
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33266638
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32117114
117Adherens junction_Homo sapiens_hsa045200.31777845
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30812553
119Systemic lupus erythematosus_Homo sapiens_hsa053220.27180632
120Retinol metabolism_Homo sapiens_hsa008300.27093374
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26862106
122AMPK signaling pathway_Homo sapiens_hsa041520.26688604
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.26275853
124Glycerolipid metabolism_Homo sapiens_hsa005610.25774729
125Fatty acid elongation_Homo sapiens_hsa000620.23344950
126mTOR signaling pathway_Homo sapiens_hsa041500.22574329

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