NRXN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.30992559
2locomotory exploration behavior (GO:0035641)6.25372577
3regulation of short-term neuronal synaptic plasticity (GO:0048172)6.19497010
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.77437577
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.77185800
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.63014286
7layer formation in cerebral cortex (GO:0021819)5.40506789
8* vocalization behavior (GO:0071625)5.32546542
9synaptic vesicle exocytosis (GO:0016079)5.14293680
10glutamate secretion (GO:0014047)5.12189601
11protein localization to synapse (GO:0035418)5.10110505
12regulation of glutamate receptor signaling pathway (GO:1900449)5.05688263
13regulation of synaptic vesicle exocytosis (GO:2000300)4.96967519
14exploration behavior (GO:0035640)4.94996072
15dendritic spine morphogenesis (GO:0060997)4.87100934
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.73920644
17gamma-aminobutyric acid transport (GO:0015812)4.63028788
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.52454268
19* neuron cell-cell adhesion (GO:0007158)4.48420461
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.40545270
21* neurotransmitter secretion (GO:0007269)4.36803869
22L-amino acid import (GO:0043092)4.36395897
23regulation of synapse structural plasticity (GO:0051823)4.35056962
24regulation of neuronal synaptic plasticity (GO:0048168)4.33790497
25regulation of synaptic vesicle transport (GO:1902803)4.33021698
26glutamate receptor signaling pathway (GO:0007215)4.22838775
27synaptic transmission, glutamatergic (GO:0035249)4.15883978
28axon ensheathment in central nervous system (GO:0032291)4.14163985
29central nervous system myelination (GO:0022010)4.14163985
30proline transport (GO:0015824)4.12218195
31neurotransmitter-gated ion channel clustering (GO:0072578)4.11699324
32neuronal action potential propagation (GO:0019227)4.10556200
33potassium ion homeostasis (GO:0055075)4.08768030
34neuron recognition (GO:0008038)3.98690938
35amino acid import (GO:0043090)3.98290159
36* postsynaptic membrane organization (GO:0001941)3.94086881
37cellular potassium ion homeostasis (GO:0030007)3.93116619
38dendrite morphogenesis (GO:0048813)3.91855014
39potassium ion import (GO:0010107)3.91357926
40positive regulation of membrane potential (GO:0045838)3.86422936
41long-term memory (GO:0007616)3.83868201
42sodium ion export (GO:0071436)3.79527791
43neuron-neuron synaptic transmission (GO:0007270)3.77279106
44positive regulation of synapse maturation (GO:0090129)3.76882807
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.75496489
46neuromuscular process controlling balance (GO:0050885)3.66358263
47regulation of excitatory postsynaptic membrane potential (GO:0060079)3.65942605
48transmission of nerve impulse (GO:0019226)3.65808458
49positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.64812362
50axonal fasciculation (GO:0007413)3.62506447
51regulation of dendritic spine morphogenesis (GO:0061001)3.62398769
52establishment of mitochondrion localization (GO:0051654)3.57388989
53* neurotransmitter transport (GO:0006836)3.56222513
54activation of protein kinase A activity (GO:0034199)3.56103216
55regulation of voltage-gated calcium channel activity (GO:1901385)3.52987069
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.51296288
57glycine transport (GO:0015816)3.51223721
58cell migration in hindbrain (GO:0021535)3.50364106
59regulation of postsynaptic membrane potential (GO:0060078)3.49530190
60cellular sodium ion homeostasis (GO:0006883)3.49410919
61regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.47477074
62pyrimidine nucleobase catabolic process (GO:0006208)3.47336036
63cerebellar granule cell differentiation (GO:0021707)3.41437755
64positive regulation of synaptic transmission, GABAergic (GO:0032230)3.39597772
65cerebellar Purkinje cell differentiation (GO:0021702)3.38107742
66regulation of neurotransmitter secretion (GO:0046928)3.38017727
67synaptic vesicle endocytosis (GO:0048488)3.36449999
68response to pheromone (GO:0019236)3.35795623
69positive regulation of dendritic spine development (GO:0060999)3.35603312
70regulation of synaptic plasticity (GO:0048167)3.34278174
71positive regulation of neurotransmitter transport (GO:0051590)3.33581440
72positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.33104193
73cell communication by electrical coupling (GO:0010644)3.31763223
74positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.31477242
75central nervous system projection neuron axonogenesis (GO:0021952)3.29551701
76cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.28829516
77* regulation of neurotransmitter levels (GO:0001505)3.26223428
78G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.24021293
79regulation of synaptic transmission, glutamatergic (GO:0051966)3.22814646
80presynaptic membrane assembly (GO:0097105)3.22572251
81dendritic spine organization (GO:0097061)3.22506121
82regulation of vesicle fusion (GO:0031338)3.22380966
83regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.21985893
84gamma-aminobutyric acid signaling pathway (GO:0007214)3.21372831
85cell differentiation in hindbrain (GO:0021533)3.20094624
86neuromuscular synaptic transmission (GO:0007274)3.15901252
87regulation of dendritic spine development (GO:0060998)3.15611661
88G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.15342524
89negative regulation of synaptic transmission, GABAergic (GO:0032229)3.14289244
90regulation of synaptic transmission (GO:0050804)3.13627438
91prepulse inhibition (GO:0060134)3.11626076
92establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.11185313
93mitochondrion transport along microtubule (GO:0047497)3.11185313
94* synapse assembly (GO:0007416)3.09750321
95neuronal ion channel clustering (GO:0045161)3.08057741
96regulation of neurotransmitter transport (GO:0051588)3.07318422
97negative regulation of dendrite morphogenesis (GO:0050774)3.05950353
98presynaptic membrane organization (GO:0097090)3.05859555
99positive regulation of dendritic spine morphogenesis (GO:0061003)3.05447339
100negative regulation of microtubule polymerization (GO:0031115)3.05283228
101membrane depolarization (GO:0051899)3.04192229
102membrane hyperpolarization (GO:0060081)3.02830026
103acidic amino acid transport (GO:0015800)3.02605966
104cerebellar Purkinje cell layer development (GO:0021680)3.02399650
105organelle transport along microtubule (GO:0072384)3.02073177
106regulation of ARF protein signal transduction (GO:0032012)3.00504590
107neurotransmitter uptake (GO:0001504)3.00489269
108innervation (GO:0060384)3.00351001
109clathrin coat assembly (GO:0048268)2.99616664
110vesicle transport along microtubule (GO:0047496)2.99531798
111positive regulation of dendrite development (GO:1900006)2.99156213
112cytoskeletal anchoring at plasma membrane (GO:0007016)2.97409365
113positive regulation of synapse assembly (GO:0051965)2.97192017
114membrane depolarization during action potential (GO:0086010)2.96680439
115neuromuscular process (GO:0050905)2.96471069
116long-term synaptic potentiation (GO:0060291)2.96284215
117* learning (GO:0007612)2.96120299
118axon cargo transport (GO:0008088)2.95428812
119positive regulation of neurotransmitter secretion (GO:0001956)2.95244991
120neuromuscular process controlling posture (GO:0050884)2.94973481
121* synapse organization (GO:0050808)2.93610221
122regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.91918242
123regulation of synapse maturation (GO:0090128)2.91139593
124nucleobase catabolic process (GO:0046113)2.90358838

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.17962943
2* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.17182274
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11381484
4GBX2_23144817_ChIP-Seq_PC3_Human3.10567531
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02591789
6* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80629252
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80629252
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.76350859
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.72940224
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.66314522
11DROSHA_22980978_ChIP-Seq_HELA_Human2.61245050
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58636255
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57443379
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.56710392
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56524665
16* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48993820
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.44849362
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.44094125
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.40156158
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.30580289
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.30046583
22* RNF2_27304074_Chip-Seq_ESCs_Mouse2.28295782
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.27205860
24* REST_18959480_ChIP-ChIP_MESCs_Mouse2.24884636
25* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.16571503
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.13353747
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.12144425
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03952624
29AR_21572438_ChIP-Seq_LNCaP_Human2.02518934
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96073868
31* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.90012672
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.69294947
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61765673
34RING1B_27294783_Chip-Seq_ESCs_Mouse1.47612074
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45218578
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44779347
37ZNF274_21170338_ChIP-Seq_K562_Hela1.44672474
38SMAD4_21799915_ChIP-Seq_A2780_Human1.43729037
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38409350
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34992651
41* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.33267442
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32476769
43RING1B_27294783_Chip-Seq_NPCs_Mouse1.28577490
44TAF15_26573619_Chip-Seq_HEK293_Human1.28476187
45* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28338976
46* KDM2B_26808549_Chip-Seq_K562_Human1.27927946
47SOX2_21211035_ChIP-Seq_LN229_Gbm1.26161323
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26035457
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.25634091
50* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23414924
51GATA1_26923725_Chip-Seq_HPCs_Mouse1.20683968
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20310526
53* AR_19668381_ChIP-Seq_PC3_Human1.18841756
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18484545
55* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17585127
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.14158179
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12486613
58* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12247316
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11817350
60* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11400124
61STAT3_23295773_ChIP-Seq_U87_Human1.09607945
62P300_19829295_ChIP-Seq_ESCs_Human1.09123754
63IGF1R_20145208_ChIP-Seq_DFB_Human1.08823469
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08597685
65* AR_25329375_ChIP-Seq_VCAP_Human1.08395421
66P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06633180
67* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06333175
68RNF2_27304074_Chip-Seq_NSC_Mouse1.05706951
69SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05438834
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05414958
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04377311
72* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04330805
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03375398
74* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01660214
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01602933
76YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01454653
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.01337789
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00365460
79ARNT_22903824_ChIP-Seq_MCF-7_Human0.99786301
80AHR_22903824_ChIP-Seq_MCF-7_Human0.98075759
81ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97613880
82* LXR_22292898_ChIP-Seq_THP-1_Human0.96647312
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96555063
84SMAD3_21741376_ChIP-Seq_ESCs_Human0.96235180
85TCF4_23295773_ChIP-Seq_U87_Human0.95355223
86* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94428535
87PIAS1_25552417_ChIP-Seq_VCAP_Human0.94399942
88* SMAD4_21741376_ChIP-Seq_HESCs_Human0.94304293
89* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93533700
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93360783
91RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92437833
92* OCT4_19829295_ChIP-Seq_ESCs_Human0.91357053
93TET1_21490601_ChIP-Seq_MESCs_Mouse0.91054996
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90970025
95CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90593082
96DPY_21335234_ChIP-Seq_ESCs_Mouse0.90354080
97ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89025516
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87927517
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87927517
100* CTCF_27219007_Chip-Seq_Bcells_Human0.87274339
101NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86894477
102RUNX2_22187159_ChIP-Seq_PCA_Human0.86854753
103DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86533263
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86110069
105GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85982073
106OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.85884115
107SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85416502
108TP53_20018659_ChIP-ChIP_R1E_Mouse0.84851124
109PRDM14_20953172_ChIP-Seq_ESCs_Human0.84203424
110* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83815239
111KLF4_19829295_ChIP-Seq_ESCs_Human0.83673531
112* SMC4_20622854_ChIP-Seq_HELA_Human0.83505776
113ESR2_21235772_ChIP-Seq_MCF-7_Human0.83362643
114CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83327050
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83055584
116* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82577885
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82114480
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78417356
119TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.78081622
120KDM2B_26808549_Chip-Seq_DND41_Human0.76641730
121* RUNX1_26923725_Chip-Seq_HPCs_Mouse0.73265152
122TP53_23651856_ChIP-Seq_MEFs_Mouse0.72358751
123SMAD4_21741376_ChIP-Seq_ESCs_Human0.71559937
124SRY_22984422_ChIP-ChIP_TESTIS_Rat0.70700968
125KDM2B_26808549_Chip-Seq_JURKAT_Human0.70626690

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.52957715
2MP0003880_abnormal_central_pattern4.43480092
3* MP0003635_abnormal_synaptic_transmissio4.17405202
4MP0004270_analgesia3.98093981
5MP0005423_abnormal_somatic_nervous3.49177251
6MP0002063_abnormal_learning/memory/cond3.31840540
7MP0009745_abnormal_behavioral_response3.31460630
8MP0009046_muscle_twitch3.09266597
9MP0002064_seizures3.05913428
10MP0001968_abnormal_touch/_nociception2.90751368
11MP0002734_abnormal_mechanical_nocicepti2.88389342
12MP0002572_abnormal_emotion/affect_behav2.71978254
13MP0001486_abnormal_startle_reflex2.60659699
14MP0002272_abnormal_nervous_system2.47204203
15MP0000778_abnormal_nervous_system2.28030260
16MP0002735_abnormal_chemical_nociception2.25003189
17MP0002733_abnormal_thermal_nociception2.24564846
18MP0001440_abnormal_grooming_behavior2.23398976
19MP0009780_abnormal_chondrocyte_physiolo2.18000939
20MP0002736_abnormal_nociception_after2.14280350
21MP0003329_amyloid_beta_deposits2.12698204
22MP0004858_abnormal_nervous_system2.10371744
23MP0001501_abnormal_sleep_pattern2.08816981
24MP0002184_abnormal_innervation2.06158849
25MP0001970_abnormal_pain_threshold2.05091529
26MP0008569_lethality_at_weaning2.01643653
27MP0002067_abnormal_sensory_capabilities1.96800456
28MP0002822_catalepsy1.91059870
29MP0004811_abnormal_neuron_physiology1.88858785
30MP0002557_abnormal_social/conspecific_i1.88050819
31MP0004885_abnormal_endolymph1.84688699
32MP0000955_abnormal_spinal_cord1.80404051
33MP0004924_abnormal_behavior1.73485526
34MP0005386_behavior/neurological_phenoty1.73485526
35MP0006276_abnormal_autonomic_nervous1.63751463
36MP0002909_abnormal_adrenal_gland1.57787363
37MP0002882_abnormal_neuron_morphology1.55580944
38MP0005645_abnormal_hypothalamus_physiol1.50751520
39MP0002066_abnormal_motor_capabilities/c1.49694173
40MP0003879_abnormal_hair_cell1.48302547
41MP0003123_paternal_imprinting1.43860544
42MP0004142_abnormal_muscle_tone1.36580811
43MP0003633_abnormal_nervous_system1.34540418
44MP0001984_abnormal_olfaction1.34212980
45MP0005646_abnormal_pituitary_gland1.32620965
46MP0000569_abnormal_digit_pigmentation1.27738626
47MP0002152_abnormal_brain_morphology1.27074694
48MP0001502_abnormal_circadian_rhythm1.22359679
49MP0003631_nervous_system_phenotype1.17738479
50MP0003787_abnormal_imprinting1.14745540
51MP0004742_abnormal_vestibular_system1.14270019
52MP0001905_abnormal_dopamine_level1.11374007
53MP0000920_abnormal_myelination1.07528897
54MP0003634_abnormal_glial_cell1.06839121
55MP0004145_abnormal_muscle_electrophysio1.04477536
56MP0002229_neurodegeneration1.02952036
57MP0001529_abnormal_vocalization1.01569989
58MP0003690_abnormal_glial_cell1.01364471
59MP0003122_maternal_imprinting0.97704947
60MP0003283_abnormal_digestive_organ0.96584313
61MP0003632_abnormal_nervous_system0.96199596
62MP0000604_amyloidosis0.95702144
63MP0000751_myopathy0.94935599
64MP0002069_abnormal_eating/drinking_beha0.93729378
65MP0005551_abnormal_eye_electrophysiolog0.90223699
66MP0001188_hyperpigmentation0.89241430
67MP0008872_abnormal_physiological_respon0.89033749
68MP0000631_abnormal_neuroendocrine_gland0.88665225
69MP0001177_atelectasis0.88417049
70MP0002752_abnormal_somatic_nervous0.87769412
71MP0001348_abnormal_lacrimal_gland0.86355405
72MP0003121_genomic_imprinting0.83632128
73MP0001963_abnormal_hearing_physiology0.83495326
74MP0008961_abnormal_basal_metabolism0.83407022
75MP0008874_decreased_physiological_sensi0.80241951
76MP0005394_taste/olfaction_phenotype0.78800982
77MP0005499_abnormal_olfactory_system0.78800982
78MP0003861_abnormal_nervous_system0.77488514
79MP0004085_abnormal_heartbeat0.77383362
80MP0003137_abnormal_impulse_conducting0.77187993
81MP0000579_abnormal_nail_morphology0.74418360
82MP0003075_altered_response_to0.73196458
83MP0001299_abnormal_eye_distance/0.70728722
84MP0005535_abnormal_body_temperature0.70429044
85MP0005409_darkened_coat_color0.70098265
86MP0005187_abnormal_penis_morphology0.69713311
87MP0001346_abnormal_lacrimal_gland0.69666288
88MP0005623_abnormal_meninges_morphology0.68737183
89MP0002638_abnormal_pupillary_reflex0.68302336
90MP0002090_abnormal_vision0.67233645
91MP0004130_abnormal_muscle_cell0.67142644
92MP0002249_abnormal_larynx_morphology0.64243936
93MP0003938_abnormal_ear_development0.63105833
94MP0004233_abnormal_muscle_weight0.62808450
95MP0002653_abnormal_ependyma_morphology0.62506271
96MP0001485_abnormal_pinna_reflex0.61496215
97MP0001986_abnormal_taste_sensitivity0.61151291
98MP0003172_abnormal_lysosome_physiology0.59954784
99MP0000013_abnormal_adipose_tissue0.59820637
100MP0008877_abnormal_DNA_methylation0.59262298
101MP0005167_abnormal_blood-brain_barrier0.58943270
102MP0010386_abnormal_urinary_bladder0.58555309
103* MP0010769_abnormal_survival0.58333710
104MP0002089_abnormal_postnatal_growth/wei0.57624158
105MP0004147_increased_porphyrin_level0.57602029
106* MP0001943_abnormal_respiration0.57531598
107MP0006072_abnormal_retinal_apoptosis0.57164762
108MP0004484_altered_response_of0.56052232
109* MP0010770_preweaning_lethality0.55761464
110* MP0002082_postnatal_lethality0.55761464
111* MP0010768_mortality/aging0.54536660
112MP0000566_synostosis0.54349846
113MP0000026_abnormal_inner_ear0.53107651
114* MP0003956_abnormal_body_size0.49944495

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.89970022
2Focal motor seizures (HP:0011153)6.13067104
3Visual hallucinations (HP:0002367)5.35459890
4Focal seizures (HP:0007359)5.25379248
5Progressive cerebellar ataxia (HP:0002073)4.66736728
6Action tremor (HP:0002345)4.40453621
7Supranuclear gaze palsy (HP:0000605)4.37687966
8Epileptic encephalopathy (HP:0200134)4.30221836
9Mutism (HP:0002300)4.21107677
10Ankle clonus (HP:0011448)3.87194627
11Broad-based gait (HP:0002136)3.66623820
12Atonic seizures (HP:0010819)3.62119921
13Febrile seizures (HP:0002373)3.59333957
14Absence seizures (HP:0002121)3.49122515
15Papilledema (HP:0001085)3.46615618
16Generalized tonic-clonic seizures (HP:0002069)3.43957533
17Poor eye contact (HP:0000817)3.39073902
18Neurofibrillary tangles (HP:0002185)3.35510284
19Urinary bladder sphincter dysfunction (HP:0002839)3.21807263
20Diplopia (HP:0000651)3.20388852
21Abnormality of binocular vision (HP:0011514)3.20388852
22Abnormality of the corticospinal tract (HP:0002492)3.16528922
23Depression (HP:0000716)3.16171028
24Dialeptic seizures (HP:0011146)3.15317444
25Genetic anticipation (HP:0003743)3.15225377
26Cerebral inclusion bodies (HP:0100314)3.13380335
27Dysdiadochokinesis (HP:0002075)3.12975455
28Abnormal social behavior (HP:0012433)3.07316487
29Impaired social interactions (HP:0000735)3.07316487
30Abnormal eating behavior (HP:0100738)3.02543348
31Hemiparesis (HP:0001269)3.02109856
32Impaired vibration sensation in the lower limbs (HP:0002166)3.00772827
33Dysmetria (HP:0001310)3.00547661
34Gaze-evoked nystagmus (HP:0000640)2.98930880
35Amyotrophic lateral sclerosis (HP:0007354)2.98226546
36Drooling (HP:0002307)2.96204483
37Excessive salivation (HP:0003781)2.96204483
38Postural instability (HP:0002172)2.93294899
39Cerebral hypomyelination (HP:0006808)2.92753440
40Anxiety (HP:0000739)2.90735412
41Limb dystonia (HP:0002451)2.88659408
42Hyperventilation (HP:0002883)2.88556087
43Tetraplegia (HP:0002445)2.87167834
44Megalencephaly (HP:0001355)2.83276315
45Spastic gait (HP:0002064)2.82741216
46Truncal ataxia (HP:0002078)2.79808865
47Torticollis (HP:0000473)2.79687817
48Urinary urgency (HP:0000012)2.74231202
49Intention tremor (HP:0002080)2.72633478
50Abnormality of the lower motor neuron (HP:0002366)2.69190206
51Hemiplegia (HP:0002301)2.68768930
52Progressive inability to walk (HP:0002505)2.64617888
53Obstructive sleep apnea (HP:0002870)2.60916584
54Amblyopia (HP:0000646)2.60861753
55Peripheral hypomyelination (HP:0007182)2.59938932
56Termporal pattern (HP:0011008)2.58586421
57Insidious onset (HP:0003587)2.58586421
58Polyphagia (HP:0002591)2.54652699
59Akinesia (HP:0002304)2.52983186
60Focal dystonia (HP:0004373)2.51638361
61Impaired smooth pursuit (HP:0007772)2.49158655
62Agitation (HP:0000713)2.48489999
63Insomnia (HP:0100785)2.43894351
64Stereotypic behavior (HP:0000733)2.41770079
65Delusions (HP:0000746)2.37850184
66Lower limb muscle weakness (HP:0007340)2.37685619
67Scanning speech (HP:0002168)2.36379655
68Bradykinesia (HP:0002067)2.33799200
69Spastic tetraparesis (HP:0001285)2.30746429
70EEG with generalized epileptiform discharges (HP:0011198)2.29418481
71Inappropriate behavior (HP:0000719)2.29361457
72Epileptiform EEG discharges (HP:0011182)2.28849078
73Fetal akinesia sequence (HP:0001989)2.28168495
74Craniofacial dystonia (HP:0012179)2.27764611
75Hypsarrhythmia (HP:0002521)2.23781773
76Apathy (HP:0000741)2.23704518
77Turricephaly (HP:0000262)2.23694811
78Abnormality of ocular smooth pursuit (HP:0000617)2.20887847
79Rigidity (HP:0002063)2.18124004
80Ventricular fibrillation (HP:0001663)2.15693691
81Morphological abnormality of the pyramidal tract (HP:0002062)2.15073793
82Absent speech (HP:0001344)2.13925254
83Inability to walk (HP:0002540)2.07531024
84Clonus (HP:0002169)2.05316881
85Generalized myoclonic seizures (HP:0002123)2.04134606
86Status epilepticus (HP:0002133)2.04081521
87Pointed chin (HP:0000307)2.03591693
88Pheochromocytoma (HP:0002666)2.02235136
89Neuronal loss in central nervous system (HP:0002529)1.99459159
90Impaired vibratory sensation (HP:0002495)1.96668456
91Split foot (HP:0001839)1.94411026
92Diminished motivation (HP:0000745)1.93615484
93Abnormality of salivation (HP:0100755)1.93558373
94Dysmetric saccades (HP:0000641)1.91848301
95Aqueductal stenosis (HP:0002410)1.91364350
96CNS hypomyelination (HP:0003429)1.90368401
97Choreoathetosis (HP:0001266)1.90270462
98Lower limb asymmetry (HP:0100559)1.90031724
99Lower limb amyotrophy (HP:0007210)1.87971582
100Sleep apnea (HP:0010535)1.87467464
101Hypoplasia of the brainstem (HP:0002365)1.86865678
102Aplasia/Hypoplasia of the brainstem (HP:0007362)1.86865678
103Increased circulating renin level (HP:0000848)1.83694569
104Spinal canal stenosis (HP:0003416)1.82662477
105Annular pancreas (HP:0001734)1.78800935
106Aplasia involving bones of the upper limbs (HP:0009823)1.78446995
107Aplasia of the phalanges of the hand (HP:0009802)1.78446995
108Aplasia involving bones of the extremities (HP:0009825)1.78446995
109Incomplete penetrance (HP:0003829)1.77202576
110Degeneration of the lateral corticospinal tracts (HP:0002314)1.76533686
111Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.76533686
112Rapidly progressive (HP:0003678)1.76133484
113Abnormality of saccadic eye movements (HP:0000570)1.75864036
114Bronchomalacia (HP:0002780)1.73047781
115Hypoplasia of the corpus callosum (HP:0002079)1.72016933

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.28710593
2MAP3K93.99277018
3NTRK33.79933287
4EPHA43.20499685
5MINK12.87930504
6MAP3K42.77601954
7NTRK22.68710722
8PAK62.51121059
9DAPK22.33792477
10MAP2K72.24399427
11NTRK12.03015117
12PHKG21.84203999
13PHKG11.84203999
14CAMKK11.83339594
15PRKD31.77969487
16MAPK131.69479279
17SIK21.68411091
18KSR21.67364958
19CDK51.61650132
20MAP2K41.59676037
21CASK1.59373494
22LATS21.58975497
23TNIK1.56418770
24KSR11.48397034
25PNCK1.43136751
26TAOK11.32677109
27UHMK11.31916951
28GRK51.29000218
29PLK21.24670219
30TYRO31.24436256
31PRKCG1.18041525
32STK381.16706946
33MAP3K121.15653690
34DAPK11.11634741
35RIPK41.05765203
36CDK191.05564651
37FES1.04534062
38STK111.04172112
39PRPF4B1.00939389
40ALK0.99878896
41CDK150.99455571
42CDK180.98543114
43MARK20.97683705
44CSNK1G20.97294368
45CDK140.96188430
46PAK30.92382650
47MAP3K20.92297790
48CAMKK20.91040592
49DYRK20.90656487
50CDK11A0.87778954
51CAMK10.87181918
52RET0.86209922
53CAMK2A0.86016007
54PRKCH0.84743125
55DYRK1A0.82920238
56PKN10.82908627
57LMTK20.78268530
58SGK4940.74414552
59SGK2230.74414552
60RIPK10.73260572
61CAMK1G0.70102663
62OXSR10.68928405
63BRSK10.68094446
64PRKCZ0.65536989
65CAMK2B0.61790232
66SGK10.60310357
67SCYL20.58810738
68FYN0.57769220
69ARAF0.56627921
70ICK0.54778520
71ERBB30.52937610
72CDC42BPA0.51798036
73MAPK120.50405238
74RPS6KA20.49780616
75MAP3K130.49475952
76RPS6KA30.49204119
77PDK10.48512352
78CSNK1G30.47810900
79TNK20.46796412
80WNK10.45917761
81SGK30.45836487
82LIMK10.45780969
83PDPK10.45522087
84PRKCE0.45267391
85WNK30.44122603
86SGK20.42368852
87RAF10.42025213
88ERBB20.41335708
89MAPK100.41248281
90PINK10.41244528
91CSNK1A1L0.40420721
92BRAF0.40260085
93NEK60.38517432
94FGR0.38360449
95MAP3K60.38047907
96ROCK20.37320134
97FGFR20.36563464
98ROCK10.36173748
99CAMK40.36083731
100MAPKAPK50.35766213
101CAMK2G0.35493936
102MAP2K60.35180698
103DAPK30.34514179
104MAP3K70.33890007
105MAPK80.33625742
106MAP3K110.33321025
107CAMK2D0.32589374
108CCNB10.32475836
109MAP3K10.32114270
110CSNK1D0.32009576
111RPS6KB10.28802263
112PRKCA0.27950627
113TESK10.27050023
114PRKG10.26909133
115GSK3B0.26784000

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.59478067
2Synaptic vesicle cycle_Homo sapiens_hsa047213.14387721
3GABAergic synapse_Homo sapiens_hsa047272.72060534
4Glutamatergic synapse_Homo sapiens_hsa047242.64681806
5Circadian entrainment_Homo sapiens_hsa047132.62692325
6Olfactory transduction_Homo sapiens_hsa047402.58887468
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.54471181
8Long-term potentiation_Homo sapiens_hsa047202.46786357
9Morphine addiction_Homo sapiens_hsa050322.41042753
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.38154080
11Amphetamine addiction_Homo sapiens_hsa050312.17640828
12Salivary secretion_Homo sapiens_hsa049702.14469979
13Dopaminergic synapse_Homo sapiens_hsa047282.10779433
14Cholinergic synapse_Homo sapiens_hsa047251.93999698
15Gastric acid secretion_Homo sapiens_hsa049711.91433987
16Insulin secretion_Homo sapiens_hsa049111.87232943
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80504517
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.73471494
19Long-term depression_Homo sapiens_hsa047301.72320450
20Taste transduction_Homo sapiens_hsa047421.69348757
21Cocaine addiction_Homo sapiens_hsa050301.62492931
22Oxytocin signaling pathway_Homo sapiens_hsa049211.60328710
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60010166
24Serotonergic synapse_Homo sapiens_hsa047261.59216637
25Renin secretion_Homo sapiens_hsa049241.57089035
26Axon guidance_Homo sapiens_hsa043601.51766781
27Gap junction_Homo sapiens_hsa045401.44655677
28Calcium signaling pathway_Homo sapiens_hsa040201.44536917
29GnRH signaling pathway_Homo sapiens_hsa049121.43707886
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34892572
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30623606
32Type II diabetes mellitus_Homo sapiens_hsa049301.27364421
33Estrogen signaling pathway_Homo sapiens_hsa049151.26463776
34cAMP signaling pathway_Homo sapiens_hsa040241.22871813
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21348034
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19925956
37Glioma_Homo sapiens_hsa052141.18924432
38ErbB signaling pathway_Homo sapiens_hsa040121.13453095
39Vitamin B6 metabolism_Homo sapiens_hsa007501.12138867
40Melanogenesis_Homo sapiens_hsa049161.09542421
41Nitrogen metabolism_Homo sapiens_hsa009101.08941285
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03048494
43cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98000401
44Collecting duct acid secretion_Homo sapiens_hsa049660.97471213
45Cardiac muscle contraction_Homo sapiens_hsa042600.96833626
46Phospholipase D signaling pathway_Homo sapiens_hsa040720.95638604
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92655645
48Dorso-ventral axis formation_Homo sapiens_hsa043200.89058141
49Phototransduction_Homo sapiens_hsa047440.85500119
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85216356
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85129161
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.84927612
53Oocyte meiosis_Homo sapiens_hsa041140.83961763
54Pancreatic secretion_Homo sapiens_hsa049720.79807206
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79187666
56Choline metabolism in cancer_Homo sapiens_hsa052310.76395005
57Thyroid hormone synthesis_Homo sapiens_hsa049180.76154578
58Dilated cardiomyopathy_Homo sapiens_hsa054140.74771827
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74568060
60MAPK signaling pathway_Homo sapiens_hsa040100.74275978
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73101123
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.72531447
63* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69023242
64Endometrial cancer_Homo sapiens_hsa052130.67032829
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.66190405
66VEGF signaling pathway_Homo sapiens_hsa043700.63384068
67Ras signaling pathway_Homo sapiens_hsa040140.63150502
68Vibrio cholerae infection_Homo sapiens_hsa051100.62662652
69Renal cell carcinoma_Homo sapiens_hsa052110.62537015
70Bile secretion_Homo sapiens_hsa049760.59427021
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58526568
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57451171
73Rap1 signaling pathway_Homo sapiens_hsa040150.56551310
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56241369
75Endocytosis_Homo sapiens_hsa041440.55662951
76mTOR signaling pathway_Homo sapiens_hsa041500.54798333
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54636132
78Alcoholism_Homo sapiens_hsa050340.54027282
79Wnt signaling pathway_Homo sapiens_hsa043100.50293489
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49018926
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46814091
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45930280
83Glucagon signaling pathway_Homo sapiens_hsa049220.45366610
84Insulin signaling pathway_Homo sapiens_hsa049100.45226985
85Prion diseases_Homo sapiens_hsa050200.45038930
86Colorectal cancer_Homo sapiens_hsa052100.43915835
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43877127
88Non-small cell lung cancer_Homo sapiens_hsa052230.42339824
89Circadian rhythm_Homo sapiens_hsa047100.41380515
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40472173
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40383266
92Ovarian steroidogenesis_Homo sapiens_hsa049130.39943918
93Inositol phosphate metabolism_Homo sapiens_hsa005620.39777451
94Chemokine signaling pathway_Homo sapiens_hsa040620.38036478
95Hippo signaling pathway_Homo sapiens_hsa043900.37449768
96Type I diabetes mellitus_Homo sapiens_hsa049400.36874587
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35366230
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35151137
99AMPK signaling pathway_Homo sapiens_hsa041520.33174152
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32962453
101Butanoate metabolism_Homo sapiens_hsa006500.30535572
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30406088
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30302756
104Hedgehog signaling pathway_Homo sapiens_hsa043400.29294701
105Arginine and proline metabolism_Homo sapiens_hsa003300.29269996
106Tight junction_Homo sapiens_hsa045300.28521445
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24716320
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24622265
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24362409
110Alzheimers disease_Homo sapiens_hsa050100.24219195
111Mineral absorption_Homo sapiens_hsa049780.23339580
112Fatty acid biosynthesis_Homo sapiens_hsa000610.23084235

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