NSA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nucleolar protein involved in cell cycle regulation and proliferation. This gene was identified based on sequence similarity to a highly conserved Saccharomyces cerevisiae gene encoding a pre-ribosomal protein, which is involved in large ribosomal subunit biogenesis. The encoded protein is found at elevated levels in diabetic nephropathy. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)8.65679139
2translational termination (GO:0006415)8.36432091
3ribosomal small subunit assembly (GO:0000028)7.43912305
4ribosomal small subunit biogenesis (GO:0042274)7.11961059
5translational elongation (GO:0006414)7.07792177
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.89724455
7protein targeting to ER (GO:0045047)6.77767364
8cotranslational protein targeting to membrane (GO:0006613)6.75132059
9nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.63149166
10ribosomal large subunit biogenesis (GO:0042273)6.53278721
11establishment of protein localization to endoplasmic reticulum (GO:0072599)6.48306980
12cellular protein complex disassembly (GO:0043624)6.39578733
13viral life cycle (GO:0019058)6.37983597
14translational initiation (GO:0006413)6.32731650
15maturation of SSU-rRNA (GO:0030490)6.28352185
16protein localization to endoplasmic reticulum (GO:0070972)6.28041722
17establishment of protein localization to mitochondrial membrane (GO:0090151)5.97276518
18chaperone-mediated protein transport (GO:0072321)5.91819732
19protein complex disassembly (GO:0043241)5.63958231
20macromolecular complex disassembly (GO:0032984)5.23450074
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.82221200
22nuclear-transcribed mRNA catabolic process (GO:0000956)4.66364344
23protein targeting to membrane (GO:0006612)4.54748032
24ribonucleoprotein complex biogenesis (GO:0022613)4.50233045
25mRNA catabolic process (GO:0006402)4.41684219
26ATP synthesis coupled proton transport (GO:0015986)4.32302225
27energy coupled proton transport, down electrochemical gradient (GO:0015985)4.32302225
28translation (GO:0006412)4.28014371
29RNA catabolic process (GO:0006401)4.17423507
30protein K11-linked deubiquitination (GO:0035871)4.05427508
31histone H3-K4 trimethylation (GO:0080182)4.00144478
32negative regulation of necroptotic process (GO:0060546)3.89299156
33cell fate commitment involved in formation of primary germ layer (GO:0060795)3.85877708
34positive regulation of histone H3-K4 methylation (GO:0051571)3.82150450
35pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.78400322
36peptidyl-histidine modification (GO:0018202)3.77256114
37mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.74482660
38behavioral response to nicotine (GO:0035095)3.73241599
39regulation of helicase activity (GO:0051095)3.71302275
40DNA deamination (GO:0045006)3.68418498
41protein targeting to mitochondrion (GO:0006626)3.64225359
42rRNA transcription (GO:0009303)3.62998950
43interferon-gamma secretion (GO:0072643)3.57390718
44detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.56848017
45maturation of 5.8S rRNA (GO:0000460)3.48969982
46ncRNA 3-end processing (GO:0043628)3.44529624
47cysteine metabolic process (GO:0006534)3.41013326
48formation of translation preinitiation complex (GO:0001731)3.36177324
49ribosome assembly (GO:0042255)3.34707761
50regulation of gamma-delta T cell differentiation (GO:0045586)3.34210282
51inner mitochondrial membrane organization (GO:0007007)3.31028539
52neural tube formation (GO:0001841)3.27949700
53respiratory electron transport chain (GO:0022904)3.27778188
54establishment of protein localization to mitochondrion (GO:0072655)3.26420108
55positive regulation of T cell cytokine production (GO:0002726)3.26171656
56electron transport chain (GO:0022900)3.26054419
57protein complex biogenesis (GO:0070271)3.25600773
58purine nucleobase biosynthetic process (GO:0009113)3.24908920
59negative regulation of thymocyte apoptotic process (GO:0070244)3.24277555
60gap junction assembly (GO:0016264)3.22228433
61mitochondrial respiratory chain complex assembly (GO:0033108)3.20523406
62protein localization to mitochondrion (GO:0070585)3.20351290
63mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.19215308
64mitochondrial respiratory chain complex I assembly (GO:0032981)3.19215308
65NADH dehydrogenase complex assembly (GO:0010257)3.19215308
66regulation of necroptotic process (GO:0060544)3.18349195
67transcytosis (GO:0045056)3.17903042
68* rRNA processing (GO:0006364)3.12782872
69nucleobase biosynthetic process (GO:0046112)3.12771878
70DNA unwinding involved in DNA replication (GO:0006268)3.12043240
71positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.11322429
72serotonin receptor signaling pathway (GO:0007210)3.10801016
73cellular component biogenesis (GO:0044085)3.10677899
74* rRNA metabolic process (GO:0016072)3.08022501
75transcription elongation from RNA polymerase III promoter (GO:0006385)3.03237909
76termination of RNA polymerase III transcription (GO:0006386)3.03237909
77regulation of mitochondrial translation (GO:0070129)3.02544836
78hematopoietic stem cell proliferation (GO:0071425)3.02125850
79receptor guanylyl cyclase signaling pathway (GO:0007168)3.00402971
80pyrimidine nucleotide catabolic process (GO:0006244)2.99106756
81regulation of gamma-delta T cell activation (GO:0046643)2.97084070
82pseudouridine synthesis (GO:0001522)2.95027192
83negative regulation of necrotic cell death (GO:0060547)2.94638868
84establishment of protein localization to membrane (GO:0090150)2.93209797
85T cell apoptotic process (GO:0070231)2.92239305
86positive regulation of hair cycle (GO:0042635)2.90639823
87positive regulation of hair follicle development (GO:0051798)2.90639823
88regulation of appetite (GO:0032098)2.89609229
89preassembly of GPI anchor in ER membrane (GO:0016254)2.87811273
90carnitine transmembrane transport (GO:1902603)2.87124822
91male meiosis I (GO:0007141)2.87112052
92establishment of viral latency (GO:0019043)2.86885289
93IMP biosynthetic process (GO:0006188)2.86315965
94mucosal-associated lymphoid tissue development (GO:0048537)2.84226445
95Peyers patch development (GO:0048541)2.84226445
96synapsis (GO:0007129)2.82163070
97base-excision repair, AP site formation (GO:0006285)2.80584637
98protein-cofactor linkage (GO:0018065)2.79546391
99mitochondrial transport (GO:0006839)2.78709122
100ribosome biogenesis (GO:0042254)2.78406304
101protein localization to kinetochore (GO:0034501)2.78100316
102regulation of histone H3-K4 methylation (GO:0051569)2.76617247
103chromatin remodeling at centromere (GO:0031055)2.76367318
104intra-S DNA damage checkpoint (GO:0031573)2.76244304
105negative regulation of translational initiation (GO:0045947)2.76143388
106DNA replication checkpoint (GO:0000076)2.73681118
107intracellular protein transmembrane import (GO:0044743)2.73182591
108mitotic G2/M transition checkpoint (GO:0044818)2.72868356
109ribonucleoprotein complex assembly (GO:0022618)2.70965399
110regulation of hair follicle development (GO:0051797)2.70549155
111water-soluble vitamin biosynthetic process (GO:0042364)2.70423811
112negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.70364926
113kinetochore organization (GO:0051383)2.70247861
114DNA strand elongation involved in DNA replication (GO:0006271)2.69900248
115establishment of protein localization to organelle (GO:0072594)2.66041421
116nuclear pore organization (GO:0006999)2.64614616
117heterochromatin organization (GO:0070828)2.64041985
118negative regulation of RNA splicing (GO:0033119)2.63184223
119alternative mRNA splicing, via spliceosome (GO:0000380)2.62466331
120oxidative phosphorylation (GO:0006119)2.61592343
121protein localization to chromosome, centromeric region (GO:0071459)2.61378852
122protein targeting (GO:0006605)2.61354147
123DNA topological change (GO:0006265)2.60294299
124dosage compensation (GO:0007549)2.58306638
125telomere maintenance via semi-conservative replication (GO:0032201)2.56542908
126regulation of interleukin-12 biosynthetic process (GO:0045075)2.56140472
127lymphocyte apoptotic process (GO:0070227)2.54981789
128regulation of chemokine secretion (GO:0090196)2.54195346
129epithelial cell-cell adhesion (GO:0090136)2.53987380
130protein localization to chromosome (GO:0034502)2.52885804
131CENP-A containing nucleosome assembly (GO:0034080)2.52320835
132DNA strand elongation (GO:0022616)2.51994573
133spliceosomal complex assembly (GO:0000245)2.48779988
134cellular component disassembly (GO:0022411)2.43986657
135spliceosomal snRNP assembly (GO:0000387)2.41119314
136pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.40387711
137termination of RNA polymerase I transcription (GO:0006363)2.39609195
138DNA replication initiation (GO:0006270)2.39564701
139positive regulation of DNA-templated transcription, elongation (GO:0032786)2.38117251
140transcription elongation from RNA polymerase I promoter (GO:0006362)2.37805381
141DNA replication-independent nucleosome organization (GO:0034724)2.32826810
142DNA replication-independent nucleosome assembly (GO:0006336)2.32826810
143regulation of translational termination (GO:0006449)2.32552093
144protein localization to membrane (GO:0072657)2.32003703
145kinetochore assembly (GO:0051382)2.30836086
146mitotic recombination (GO:0006312)2.30074967
147folic acid-containing compound biosynthetic process (GO:0009396)2.29952809
148gene expression (GO:0010467)2.29916909
149telomere maintenance via recombination (GO:0000722)2.29883694
150regulation of thymocyte apoptotic process (GO:0070243)2.28574392
151regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)2.27631196
152peptidyl-lysine trimethylation (GO:0018023)2.27164671
153deoxyribonucleotide catabolic process (GO:0009264)2.24604775
154positive regulation of histone methylation (GO:0031062)2.24445479

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.44829229
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.34287385
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.63903498
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.51428354
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.24468040
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.05757748
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.96750009
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.88943048
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.58285591
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.53978744
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.47618761
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.46427144
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.44074839
14XRN2_22483619_ChIP-Seq_HELA_Human2.41988299
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.41404894
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.39738566
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.37984064
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.31100620
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.25045255
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.23094781
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13348300
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.10375640
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.07319815
24ELK1_19687146_ChIP-ChIP_HELA_Human1.99929170
25* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.97024141
26MYC_22102868_ChIP-Seq_BL_Human1.96283183
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.93469456
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.91746306
29TTF2_22483619_ChIP-Seq_HELA_Human1.91735669
30DCP1A_22483619_ChIP-Seq_HELA_Human1.90846976
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.89565285
32* VDR_23849224_ChIP-Seq_CD4+_Human1.88881421
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.82143408
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.81336636
35AR_21909140_ChIP-Seq_LNCAP_Human1.78537078
36* FOXP3_21729870_ChIP-Seq_TREG_Human1.72011558
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69468329
38VDR_21846776_ChIP-Seq_THP-1_Human1.66933113
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.64874167
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.57741487
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.53879666
42KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.52344655
43KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.52344655
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.52344655
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.52201506
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51817909
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.48612061
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.47801040
49FUS_26573619_Chip-Seq_HEK293_Human1.44262333
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.44141149
51EWS_26573619_Chip-Seq_HEK293_Human1.43910153
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42323102
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40343458
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38556246
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38225018
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35012931
57CIITA_25753668_ChIP-Seq_RAJI_Human1.34342025
58IRF1_19129219_ChIP-ChIP_H3396_Human1.34182974
59KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.33701143
60* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33621816
61GABP_19822575_ChIP-Seq_HepG2_Human1.33602616
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32950416
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.32810848
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32610963
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.30075100
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.30050412
67KDM5A_27292631_Chip-Seq_BREAST_Human1.28939504
68SPI1_23547873_ChIP-Seq_NB4_Human1.26294297
69BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.25801857
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25409993
71ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.24428339
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24077860
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23790991
74IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22963128
75ZNF263_19887448_ChIP-Seq_K562_Human1.22582070
76MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22489798
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21128010
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20117117
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19755414
80CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.18309685
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18277646
82TP53_22573176_ChIP-Seq_HFKS_Human1.15885977
83MAF_26560356_Chip-Seq_TH1_Human1.15461630
84STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14211125
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14166012
86UTX_26944678_Chip-Seq_JUKART_Human1.13175300
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12842154
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12471146
89* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12272604
90FLI1_27457419_Chip-Seq_LIVER_Mouse1.10452985
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.09529050
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08914933
93ELF5_23300383_ChIP-Seq_T47D_Human1.08451319
94MYC_18940864_ChIP-ChIP_HL60_Human1.08233565
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07975166
96STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06893473
97IRF8_22096565_ChIP-ChIP_GC-B_Human1.04487618
98NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03508403
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03216229
100CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02898799
101POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00919561
102VDR_24763502_ChIP-Seq_THP-1_Human0.99115404
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98142990
104MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97908343
105SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97552276
106OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96884746
107HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96850832
108* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.96338265
109BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96296568
110CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94650626
111IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94224414
112RUNX1_22412390_ChIP-Seq_EML_Mouse0.92779342
113MYB_26560356_Chip-Seq_TH1_Human0.92433854
114MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92313686
115YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91885807
116GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91812551
117SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91772894
118ZNF274_21170338_ChIP-Seq_K562_Hela0.91132509
119THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90144928
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90109581
121STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.89949258
122TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89265489
123REST_19997604_ChIP-ChIP_NEURONS_Mouse0.87919244
124CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83800808
125EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.83344761
126ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82578161
127PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.81804189
128MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.80149412
129KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77120967
130TAF15_26573619_Chip-Seq_HEK293_Human0.73430295
131CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.73150211
132FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.72244836
133BMI1_23680149_ChIP-Seq_NPCS_Mouse0.70181135
134TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.69329718
135VDR_22108803_ChIP-Seq_LS180_Human0.69316360
136POU5F1_16153702_ChIP-ChIP_HESCs_Human0.68380070
137SALL1_21062744_ChIP-ChIP_HESCs_Human0.68307770
138SOX2_16153702_ChIP-ChIP_HESCs_Human0.67873096

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose3.69150071
2MP0003300_gastrointestinal_ulcer3.56386563
3MP0003806_abnormal_nucleotide_metabolis3.53606827
4MP0004957_abnormal_blastocyst_morpholog3.31595240
5MP0009379_abnormal_foot_pigmentation3.16324304
6MP0006292_abnormal_olfactory_placode3.04144996
7MP0003693_abnormal_embryo_hatching3.01391353
8MP0002009_preneoplasia2.85280769
9MP0003077_abnormal_cell_cycle2.31479864
10MP0002163_abnormal_gland_morphology2.31472795
11MP0002166_altered_tumor_susceptibility2.15522237
12MP0003183_abnormal_peptide_metabolism2.12976824
13MP0002006_tumorigenesis2.11998618
14MP0003763_abnormal_thymus_physiology2.08182884
15MP0005389_reproductive_system_phenotype2.06271798
16MP0006036_abnormal_mitochondrial_physio2.05436737
17MP0003646_muscle_fatigue2.05413499
18MP0002396_abnormal_hematopoietic_system2.04817699
19MP0001919_abnormal_reproductive_system2.04187922
20MP0003111_abnormal_nucleus_morphology2.01790838
21MP0003436_decreased_susceptibility_to2.00474475
22MP0002160_abnormal_reproductive_system1.99724111
23MP0010094_abnormal_chromosome_stability1.85564054
24MP0003566_abnormal_cell_adhesion1.83554287
25MP0010155_abnormal_intestine_physiology1.79475441
26MP0000490_abnormal_crypts_of1.79208012
27MP0008057_abnormal_DNA_replication1.74755324
28MP0003866_abnormal_defecation1.74120034
29MP0005501_abnormal_skin_physiology1.70006596
30MP0003186_abnormal_redox_activity1.67734842
31MP0008007_abnormal_cellular_replicative1.66666142
32MP0003567_abnormal_fetal_cardiomyocyte1.65850214
33MP0010352_gastrointestinal_tract_polyps1.64868455
34MP0004808_abnormal_hematopoietic_stem1.55343682
35MP0001800_abnormal_humoral_immune1.52967298
36MP0003718_maternal_effect1.52302421
37MP0003123_paternal_imprinting1.50292190
38MP0008875_abnormal_xenobiotic_pharmacok1.48310675
39MP0009697_abnormal_copulation1.46319599
40MP0010234_abnormal_vibrissa_follicle1.45710719
41MP0000350_abnormal_cell_proliferation1.44708295
42MP0005387_immune_system_phenotype1.42479174
43MP0001790_abnormal_immune_system1.42479174
44MP0008932_abnormal_embryonic_tissue1.42103559
45MP0000631_abnormal_neuroendocrine_gland1.41072577
46MP0009333_abnormal_splenocyte_physiolog1.40009488
47MP0005379_endocrine/exocrine_gland_phen1.38922083
48MP0002098_abnormal_vibrissa_morphology1.38028703
49MP0003705_abnormal_hypodermis_morpholog1.37590039
50MP0002210_abnormal_sex_determination1.34978194
51MP0008789_abnormal_olfactory_epithelium1.34479457
52MP0002796_impaired_skin_barrier1.33569863
53MP0006035_abnormal_mitochondrial_morpho1.33045139
54MP0003453_abnormal_keratinocyte_physiol1.32869444
55MP0003011_delayed_dark_adaptation1.32481026
56MP0009785_altered_susceptibility_to1.30531318
57MP0000477_abnormal_intestine_morphology1.29165283
58MP0001835_abnormal_antigen_presentation1.27034778
59MP0002398_abnormal_bone_marrow1.26509623
60MP0009053_abnormal_anal_canal1.26233608
61MP0002234_abnormal_pharynx_morphology1.24119937
62MP0001730_embryonic_growth_arrest1.23798449
63MP0005025_abnormal_response_to1.20585256
64MP0005084_abnormal_gallbladder_morpholo1.20031666
65MP0002277_abnormal_respiratory_mucosa1.19596815
66MP0002452_abnormal_antigen_presenting1.18035232
67MP0000685_abnormal_immune_system1.17386706
68MP0005408_hypopigmentation1.17125787
69MP0002722_abnormal_immune_system1.17007137
70MP0003303_peritoneal_inflammation1.16650715
71MP0004043_abnormal_pH_regulation1.16530841
72MP0000703_abnormal_thymus_morphology1.15051173
73MP0002420_abnormal_adaptive_immunity1.14864688
74MP0000613_abnormal_salivary_gland1.13585686
75MP0001819_abnormal_immune_cell1.13412031
76MP0001764_abnormal_homeostasis1.13226325
77MP0003890_abnormal_embryonic-extraembry1.12482506
78MP0003315_abnormal_perineum_morphology1.12226344
79MP0001216_abnormal_epidermal_layer1.11380141
80MP0001243_abnormal_dermal_layer1.11358688
81MP0000537_abnormal_urethra_morphology1.11339498
82MP0001873_stomach_inflammation1.11043477
83MP0003221_abnormal_cardiomyocyte_apopto1.10705725
84MP0008058_abnormal_DNA_repair1.09368024
85MP0002970_abnormal_white_adipose1.09365882
86MP0000689_abnormal_spleen_morphology1.09337344
87MP0002019_abnormal_tumor_incidence1.09222984
88MP0004264_abnormal_extraembryonic_tissu1.08693614
89MP0005000_abnormal_immune_tolerance1.07408944
90MP0002086_abnormal_extraembryonic_tissu1.06107492
91MP0001697_abnormal_embryo_size1.05483631
92MP0002723_abnormal_immune_serum1.05432614
93MP0002095_abnormal_skin_pigmentation1.05204713
94MP0001188_hyperpigmentation1.02847961
95MP0000716_abnormal_immune_system1.02465757
96MP0003786_premature_aging1.00854547
97MP0001145_abnormal_male_reproductive1.00784437
98MP0002429_abnormal_blood_cell0.99611469
99MP0002139_abnormal_hepatobiliary_system0.99020167
100MP0004036_abnormal_muscle_relaxation0.97715919
101MP0003941_abnormal_skin_development0.96921542
102MP0005380_embryogenesis_phenotype0.96494002
103MP0001672_abnormal_embryogenesis/_devel0.96494002
104MP0005310_abnormal_salivary_gland0.95582211
105MP0002148_abnormal_hypersensitivity_rea0.94748797
106MP0000377_abnormal_hair_follicle0.94728449
107MP0004185_abnormal_adipocyte_glucose0.94393717
108MP0006072_abnormal_retinal_apoptosis0.94128805
109MP0003937_abnormal_limbs/digits/tail_de0.93584716
110MP0004947_skin_inflammation0.93523698
111MP0003252_abnormal_bile_duct0.93167455
112MP0002060_abnormal_skin_morphology0.93109327
113MP0002933_joint_inflammation0.92502397
114MP0002088_abnormal_embryonic_growth/wei0.90964946
115MP0001293_anophthalmia0.90952260
116MP0002080_prenatal_lethality0.90718651
117MP0000653_abnormal_sex_gland0.89931069
118MP0003984_embryonic_growth_retardation0.89868753
119MP0002085_abnormal_embryonic_tissue0.89382927
120MP0003787_abnormal_imprinting0.88127025
121MP0001986_abnormal_taste_sensitivity0.88104884
122MP0002405_respiratory_system_inflammati0.87792656
123MP0008995_early_reproductive_senescence0.87651483
124MP0003936_abnormal_reproductive_system0.87317467
125MP0000858_altered_metastatic_potential0.86856210
126MP0004197_abnormal_fetal_growth/weight/0.86791300
127MP0000313_abnormal_cell_death0.86748212
128MP0002928_abnormal_bile_duct0.86460140
129MP0005671_abnormal_response_to0.86282515
130MP0006054_spinal_hemorrhage0.83751187
131MP0000372_irregular_coat_pigmentation0.83098919
132MP0010030_abnormal_orbit_morphology0.82796537
133MP0005174_abnormal_tail_pigmentation0.82732799
134MP0000383_abnormal_hair_follicle0.82358112
135MP0003119_abnormal_digestive_system0.82311558
136MP0010307_abnormal_tumor_latency0.80442151
137MP0002909_abnormal_adrenal_gland0.79225872
138MP0002938_white_spotting0.79137294
139MP0002138_abnormal_hepatobiliary_system0.78724998
140MP0005023_abnormal_wound_healing0.78280920
141MP0002111_abnormal_tail_morphology0.77869906
142MP0010771_integument_phenotype0.76510377
143MP0005499_abnormal_olfactory_system0.76140232
144MP0005394_taste/olfaction_phenotype0.76140232
145MP0008877_abnormal_DNA_methylation0.75310331
146MP0001929_abnormal_gametogenesis0.75221474
147MP0001845_abnormal_inflammatory_respons0.74530527
148MP0001346_abnormal_lacrimal_gland0.74501139
149MP0001186_pigmentation_phenotype0.74134296
150MP0005666_abnormal_adipose_tissue0.73754089
151MP0001545_abnormal_hematopoietic_system0.73364216
152MP0005397_hematopoietic_system_phenotyp0.73364216
153MP0001533_abnormal_skeleton_physiology0.72302766
154MP0008961_abnormal_basal_metabolism0.71737687
155MP0004233_abnormal_muscle_weight0.71587862
156MP0004145_abnormal_muscle_electrophysio0.69597082
157MP0002837_dystrophic_cardiac_calcinosis0.69304885
158MP0002233_abnormal_nose_morphology0.68832333
159MP0005187_abnormal_penis_morphology0.66092125
160MP0005647_abnormal_sex_gland0.65840700
161MP0004142_abnormal_muscle_tone0.59882863
162MP0005551_abnormal_eye_electrophysiolog0.58753182
163MP0000049_abnormal_middle_ear0.57722849
164MP0002084_abnormal_developmental_patter0.57193258
165MP0003959_abnormal_lean_body0.55492376

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)7.10154736
2Reticulocytopenia (HP:0001896)6.71692129
3Abnormal number of erythroid precursors (HP:0012131)5.82092426
4Macrocytic anemia (HP:0001972)5.46446736
5Pallor (HP:0000980)4.97160521
6Volvulus (HP:0002580)4.58907667
7Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.34993582
8Decreased activity of mitochondrial respiratory chain (HP:0008972)4.34993582
9Abnormal hemoglobin (HP:0011902)3.76021082
10Increased muscle lipid content (HP:0009058)3.70719011
11Acute encephalopathy (HP:0006846)3.49562380
12Mitochondrial inheritance (HP:0001427)3.47106187
13Acute necrotizing encephalopathy (HP:0006965)3.46696031
14Proximal placement of thumb (HP:0009623)3.34498031
15Thrombocytosis (HP:0001894)3.30075961
16Increased CSF lactate (HP:0002490)3.28514270
17Multiple enchondromatosis (HP:0005701)3.16927171
18Renal Fanconi syndrome (HP:0001994)3.14941626
19Blepharitis (HP:0000498)3.14772219
20Deviation of the thumb (HP:0009603)3.12857889
21Methylmalonic acidemia (HP:0002912)3.09694376
22Abnormal mitochondria in muscle tissue (HP:0008316)3.08896441
23Hyperglycinemia (HP:0002154)3.08106259
24Colon cancer (HP:0003003)3.04961506
25Hepatic necrosis (HP:0002605)2.95111465
26Atresia of the external auditory canal (HP:0000413)2.86817427
27Methylmalonic aciduria (HP:0012120)2.84957276
28Progressive macrocephaly (HP:0004481)2.81147991
29Vertebral clefting (HP:0008428)2.74802334
30Trismus (HP:0000211)2.73727647
31Respiratory difficulties (HP:0002880)2.70927941
32IgM deficiency (HP:0002850)2.69164045
33Aplasia/Hypoplasia of the sacrum (HP:0008517)2.66163062
34Gout (HP:0001997)2.60965804
35Respiratory failure (HP:0002878)2.59721952
36Lactic acidosis (HP:0003128)2.59437062
37Glycosuria (HP:0003076)2.59387196
38Abnormality of urine glucose concentration (HP:0011016)2.59387196
39Cerebral edema (HP:0002181)2.50028907
40Stenosis of the external auditory canal (HP:0000402)2.38760585
41Increased intramyocellular lipid droplets (HP:0012240)2.37188822
42Increased nuchal translucency (HP:0010880)2.34621213
43Abnormality of renal resorption (HP:0011038)2.30302571
44Increased serum lactate (HP:0002151)2.28851988
45Megaloblastic anemia (HP:0001889)2.25112992
46Petechiae (HP:0000967)2.23463183
47Abnormality of the preputium (HP:0100587)2.22491352
48Absent thumb (HP:0009777)2.20852934
49Lethargy (HP:0001254)2.20664230
50Abnormality of reticulocytes (HP:0004312)2.19697809
51Depressed nasal ridge (HP:0000457)2.19589549
52Tubulointerstitial nephritis (HP:0001970)2.17928704
53Hyperglycinuria (HP:0003108)2.16111439
54Ureteral duplication (HP:0000073)2.15433201
55Hypoplasia of the uterus (HP:0000013)2.15107782
56Congenital, generalized hypertrichosis (HP:0004540)2.14820862
57Pili torti (HP:0003777)2.14801347
58Abnormality of serum amino acid levels (HP:0003112)2.13226869
59Enlarged kidneys (HP:0000105)2.09981339
60Thick lower lip vermilion (HP:0000179)2.09265872
61Cerebral hypomyelination (HP:0006808)2.09043272
62Nephrogenic diabetes insipidus (HP:0009806)2.08821962
63Dicarboxylic aciduria (HP:0003215)2.06530730
64Abnormality of dicarboxylic acid metabolism (HP:0010995)2.06530730
65Chromsome breakage (HP:0040012)2.06115498
66Abnormality of the vitamin B12 metabolism (HP:0004341)2.04544997
67Spontaneous hematomas (HP:0007420)2.04052672
68Woolly hair (HP:0002224)2.03850742
69CNS demyelination (HP:0007305)2.03074407
70Oral leukoplakia (HP:0002745)2.01348288
71Exostoses (HP:0100777)2.01316706
72Exertional dyspnea (HP:0002875)2.00013803
73Cutis marmorata (HP:0000965)1.99639909
743-Methylglutaconic aciduria (HP:0003535)1.98816495
75Abnormality of T cells (HP:0002843)1.98784580
76Abnormality of the anterior horn cell (HP:0006802)1.98736873
77Degeneration of anterior horn cells (HP:0002398)1.98736873
78Conjugated hyperbilirubinemia (HP:0002908)1.98500242
79Neoplasm of the pancreas (HP:0002894)1.98450949
80Abnormality of chromosome stability (HP:0003220)1.97839563
81Elevated erythrocyte sedimentation rate (HP:0003565)1.96606228
82Abnormality of vitamin B metabolism (HP:0004340)1.95135856
83Abnormality of T cell physiology (HP:0011840)1.94531649
84Abnormality of serine family amino acid metabolism (HP:0010894)1.93733589
85Abnormality of glycine metabolism (HP:0010895)1.93733589
86Bicuspid aortic valve (HP:0001647)1.93715415
8711 pairs of ribs (HP:0000878)1.93422579
88Migraine (HP:0002076)1.93234390
89Aplastic anemia (HP:0001915)1.92517918
90Increased IgE level (HP:0003212)1.92303740
91Abnormal lung lobation (HP:0002101)1.91757103
92Metabolic acidosis (HP:0001942)1.89102150
93Aplasia/Hypoplasia of the thymus (HP:0010515)1.89003607
94Aplasia/Hypoplasia of the patella (HP:0006498)1.88992233
95Increased hepatocellular lipid droplets (HP:0006565)1.88609465
96Glossoptosis (HP:0000162)1.87686746
97Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.86398387
98Abnormal pancreas size (HP:0012094)1.86234450
99Hip dysplasia (HP:0001385)1.84114818
100Patellar aplasia (HP:0006443)1.83960394
101Hemivertebrae (HP:0002937)1.83167960
102Abnormal platelet volume (HP:0011876)1.82608384
103Recurrent bronchitis (HP:0002837)1.82189303
104Agammaglobulinemia (HP:0004432)1.82159007
105T lymphocytopenia (HP:0005403)1.80145841
106Chromosomal breakage induced by crosslinking agents (HP:0003221)1.79674653
107Cellulitis (HP:0100658)1.79501796
108Basal cell carcinoma (HP:0002671)1.77557335
109Esophageal neoplasm (HP:0100751)1.77495870
110Neoplasm of head and neck (HP:0012288)1.77495870
111Meckel diverticulum (HP:0002245)1.77374538
112Hyperammonemia (HP:0001987)1.77331534
113Pancytopenia (HP:0001876)1.77262650
114Hyperinsulinemic hypoglycemia (HP:0000825)1.77004223
115Selective tooth agenesis (HP:0001592)1.76259720
116Gonadotropin excess (HP:0000837)1.75847673
117Triphalangeal thumb (HP:0001199)1.75712046
118Cerebral hemorrhage (HP:0001342)1.75376874
119Abnormality of methionine metabolism (HP:0010901)1.75124258
120Aplasia/Hypoplasia of the uvula (HP:0010293)1.74797923
121Wide intermamillary distance (HP:0006610)1.74075066
122Abnormal delayed hypersensitivity skin test (HP:0002963)1.73213848
123Pustule (HP:0200039)1.73038546
124Aplasia/hypoplasia of the uterus (HP:0008684)1.72856807
125Congenital sensorineural hearing impairment (HP:0008527)1.72448988
126Facial cleft (HP:0002006)1.71135261
127Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.71001084
128Abnormality of placental membranes (HP:0011409)1.70768637
129Amniotic constriction ring (HP:0009775)1.70768637
130Recurrent viral infections (HP:0004429)1.70186580
131Poikiloderma (HP:0001029)1.69190789
132Fragile nails (HP:0001808)1.68785887
133Leukodystrophy (HP:0002415)1.68739815
134Low anterior hairline (HP:0000294)1.66178336
135Abnormality of T cell number (HP:0011839)1.66001189
136Breast hypoplasia (HP:0003187)1.65921624
137Chronic obstructive pulmonary disease (HP:0006510)1.64125728
138Obstructive lung disease (HP:0006536)1.64125728
139Hypochromic anemia (HP:0001931)1.64043625
140Cleft eyelid (HP:0000625)1.63993309
141Confusion (HP:0001289)1.63650593
142Submucous cleft hard palate (HP:0000176)1.63516171
143Abnormality of the ileum (HP:0001549)1.62279965
144Recurrent fungal infections (HP:0002841)1.61919299
145Rhabdomyosarcoma (HP:0002859)1.61616686
146Eczematoid dermatitis (HP:0000976)1.61135344
147Myelodysplasia (HP:0002863)1.60991148
148Lymphoma (HP:0002665)1.60984987
149Chronic otitis media (HP:0000389)1.60783534
150Prolonged bleeding time (HP:0003010)1.60646265
151Carpal bone hypoplasia (HP:0001498)1.60609781
152Sparse eyelashes (HP:0000653)1.60249205
153Small intestinal stenosis (HP:0012848)1.60085270
154IgG deficiency (HP:0004315)1.59584469
155Rectal prolapse (HP:0002035)1.58835677
156Panhypogammaglobulinemia (HP:0003139)1.58629024
157Hepatocellular necrosis (HP:0001404)1.58522041
158Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.58391504
159Hypoplasia of the radius (HP:0002984)1.57834547
160Lipid accumulation in hepatocytes (HP:0006561)1.56406687
161Abnormality of proline metabolism (HP:0010907)1.55735575
162Hydroxyprolinuria (HP:0003080)1.55735575
163Congenital ichthyosiform erythroderma (HP:0007431)1.55349898
164Entropion (HP:0000621)1.54931390
165Biliary tract neoplasm (HP:0100574)1.53527347
166Ankle contracture (HP:0006466)1.53365725
167Increased density of long bones (HP:0006392)1.52848820
168Neoplasm of the colon (HP:0100273)1.51682561
169Impulsivity (HP:0100710)1.51410135
170Squamous cell carcinoma (HP:0002860)1.51007188
171Skin ulcer (HP:0200042)1.49926626
172Abnormality of the thymus (HP:0000777)1.49687582
173Abnormal cartilage morphology (HP:0002763)1.49455029
174Abnormality of cells of the lymphoid lineage (HP:0012140)1.49439632
175Erythroderma (HP:0001019)1.46515786

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NUAK14.73976598
2MST43.75213246
3ERN13.67684297
4NME23.51728892
5CDK193.40740139
6NEK13.30682767
7DMPK3.26803569
8STK38L2.93367147
9TLK12.90952466
10TEC2.90579863
11STK162.43514929
12PIK3CA2.39047633
13BUB12.37592597
14ILK2.34220969
15WNK32.14021985
16PKN22.10555700
17EEF2K2.05582736
18RAF12.02499453
19VRK21.87186115
20CDC71.87159943
21IRAK21.85728509
22MAP4K11.85519537
23WEE11.84706170
24MAP3K71.81746924
25LRRK21.80090406
26FRK1.69399401
27TGFBR11.64004070
28MAP3K101.62329568
29RPS6KB21.61620824
30WNK41.60624919
31STK391.59669906
32SRPK11.57074418
33NEK21.53190978
34CDK41.49411167
35ADRBK21.47735497
36EPHB21.43897003
37MAP2K21.40186200
38MKNK11.39138391
39EIF2AK11.38552352
40STK101.31081606
41STK241.31069913
42DYRK21.23275697
43FLT31.21739842
44YES11.21552772
45PASK1.20927614
46RPS6KA41.17850226
47AURKB1.16165365
48EIF2AK21.12001631
49TRIB31.10815605
50TAF11.05171112
51CSNK1E0.99239763
52MKNK20.99057248
53BTK0.98461477
54ZAP700.95549709
55TESK20.93721890
56CDK70.89684185
57PNCK0.88848482
58DYRK30.85847231
59PLK10.85494746
60BLK0.84402346
61CDK60.83435857
62BRSK20.82497515
63PIM10.81213469
64PINK10.80816912
65CDK30.80778960
66PIM20.79511747
67GRK60.79505069
68IKBKB0.78730205
69ACVR1B0.78199495
70NEK90.77901207
71TYK20.77403927
72KIT0.75974758
73TTK0.75161283
74MAP3K80.73352909
75NLK0.72387007
76JAK30.72116136
77MAP2K10.70674572
78TBK10.69746809
79PAK40.68895053
80PDK20.68849849
81TXK0.68050390
82ADRBK10.67238260
83CSNK1G30.66251612
84CDK120.66239845
85STK110.65334199
86SCYL20.64007446
87KDR0.63680365
88PAK10.62990707
89CSNK1G10.60692421
90CSNK2A10.59091400
91CSNK2A20.59067654
92ITK0.58504632
93STK40.58218587
94CSK0.58064629
95ATR0.55268778
96ATM0.55079309
97OXSR10.55043004
98CHEK10.52301114
99CSNK1A1L0.51783729
100TGFBR20.51312223
101CLK10.49893800
102MAP2K30.49036598
103ALK0.48822438
104CCNB10.48773386
105EIF2AK30.48396523
106PBK0.46709093
107CSF1R0.45978153
108CSNK1G20.45531237
109VRK10.45232388
110IKBKE0.42431143
111TSSK60.41989207
112CDK10.41958435
113SYK0.41697409
114CHEK20.41513618
115LCK0.40934840
116ROCK20.40596386
117AURKA0.39703351
118FGFR40.39401631
119BMPR1B0.39374438
120PLK40.39180425
121CSNK1A10.39137718
122RPS6KA50.38948250
123LYN0.38559431
124EPHA20.38150721
125PLK30.37371469
126CHUK0.37200797
127GRK10.37139052
128CDK80.36074681
129RPS6KB10.35599879
130NME10.34769671
131MELK0.34750800
132STK380.34544214
133MAPKAPK50.34132141
134PAK20.34032133
135MARK30.33957526
136ZAK0.32771251
137CDK20.32673653
138STK30.31852952
139TNK20.31652238
140PRKDC0.30385357
141MAP2K60.29167356
142TNIK0.27515705
143MAPK140.27148084
144BCKDK0.23613214

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.20120855
2DNA replication_Homo sapiens_hsa030303.60516612
3Mismatch repair_Homo sapiens_hsa034303.35034569
4Spliceosome_Homo sapiens_hsa030402.68551328
5Homologous recombination_Homo sapiens_hsa034402.43901894
6RNA polymerase_Homo sapiens_hsa030202.41898684
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.38848366
8RNA transport_Homo sapiens_hsa030132.15572241
9Proteasome_Homo sapiens_hsa030502.07673003
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.97961448
11Pyrimidine metabolism_Homo sapiens_hsa002401.83055782
12Cell cycle_Homo sapiens_hsa041101.80342805
13Nucleotide excision repair_Homo sapiens_hsa034201.80175016
14Base excision repair_Homo sapiens_hsa034101.79993378
15Alzheimers disease_Homo sapiens_hsa050101.77611136
16Selenocompound metabolism_Homo sapiens_hsa004501.72464311
17Propanoate metabolism_Homo sapiens_hsa006401.67955754
18One carbon pool by folate_Homo sapiens_hsa006701.58461459
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.55220924
20Antigen processing and presentation_Homo sapiens_hsa046121.41711873
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38713139
22Primary immunodeficiency_Homo sapiens_hsa053401.34690538
23Adherens junction_Homo sapiens_hsa045201.32299290
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.31747063
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.30735659
26Leishmaniasis_Homo sapiens_hsa051401.29103929
27Herpes simplex infection_Homo sapiens_hsa051681.27160685
28Systemic lupus erythematosus_Homo sapiens_hsa053221.26241615
29p53 signaling pathway_Homo sapiens_hsa041151.23363729
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22456909
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21979499
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21882155
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20363855
34mRNA surveillance pathway_Homo sapiens_hsa030151.18233381
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.13466577
36Epstein-Barr virus infection_Homo sapiens_hsa051691.11223084
37Measles_Homo sapiens_hsa051621.09432863
38Non-homologous end-joining_Homo sapiens_hsa034501.08721658
39Folate biosynthesis_Homo sapiens_hsa007901.05199202
40RNA degradation_Homo sapiens_hsa030181.05077047
41Cardiac muscle contraction_Homo sapiens_hsa042601.04605410
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03040916
43Fanconi anemia pathway_Homo sapiens_hsa034601.02618250
44Maturity onset diabetes of the young_Homo sapiens_hsa049500.98233623
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95247706
46Basal transcription factors_Homo sapiens_hsa030220.92139760
47Glycosaminoglycan degradation_Homo sapiens_hsa005310.90898571
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87832348
49Cyanoamino acid metabolism_Homo sapiens_hsa004600.86643413
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85572470
51Hematopoietic cell lineage_Homo sapiens_hsa046400.84097822
52Viral carcinogenesis_Homo sapiens_hsa052030.82939069
53Glutathione metabolism_Homo sapiens_hsa004800.82908780
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.81662139
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81445721
56T cell receptor signaling pathway_Homo sapiens_hsa046600.77670224
57HTLV-I infection_Homo sapiens_hsa051660.77397392
58Acute myeloid leukemia_Homo sapiens_hsa052210.77111409
59Sulfur relay system_Homo sapiens_hsa041220.75896340
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75192428
61Thyroid cancer_Homo sapiens_hsa052160.74387570
62Toxoplasmosis_Homo sapiens_hsa051450.74319582
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74174366
64Parkinsons disease_Homo sapiens_hsa050120.72799928
65Small cell lung cancer_Homo sapiens_hsa052220.72021074
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70243108
67Autoimmune thyroid disease_Homo sapiens_hsa053200.69881319
68Legionellosis_Homo sapiens_hsa051340.69301773
69Olfactory transduction_Homo sapiens_hsa047400.68348361
70Type I diabetes mellitus_Homo sapiens_hsa049400.67318522
71Staphylococcus aureus infection_Homo sapiens_hsa051500.67136766
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66254555
73Osteoclast differentiation_Homo sapiens_hsa043800.65789842
74Purine metabolism_Homo sapiens_hsa002300.65255138
75MicroRNAs in cancer_Homo sapiens_hsa052060.64728686
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64470678
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64470130
78Metabolic pathways_Homo sapiens_hsa011000.63345244
79Protein export_Homo sapiens_hsa030600.63334571
80Tyrosine metabolism_Homo sapiens_hsa003500.60700579
81Apoptosis_Homo sapiens_hsa042100.60670953
82Chronic myeloid leukemia_Homo sapiens_hsa052200.60173430
83Oxidative phosphorylation_Homo sapiens_hsa001900.58784818
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58436125
85Vitamin B6 metabolism_Homo sapiens_hsa007500.58337020
86B cell receptor signaling pathway_Homo sapiens_hsa046620.57079123
87Shigellosis_Homo sapiens_hsa051310.56925966
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56032936
89Butanoate metabolism_Homo sapiens_hsa006500.55179183
90Endometrial cancer_Homo sapiens_hsa052130.54770221
91Fatty acid degradation_Homo sapiens_hsa000710.54461310
92Graft-versus-host disease_Homo sapiens_hsa053320.54364262
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53800641
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.53156053
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52540963
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52449895
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52163633
98Huntingtons disease_Homo sapiens_hsa050160.51996512
99Viral myocarditis_Homo sapiens_hsa054160.51917291
100Arachidonic acid metabolism_Homo sapiens_hsa005900.49981124
101Hepatitis B_Homo sapiens_hsa051610.49506458
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48949762
103Salmonella infection_Homo sapiens_hsa051320.48945507
104Vitamin digestion and absorption_Homo sapiens_hsa049770.48594721
105Bladder cancer_Homo sapiens_hsa052190.48125030
106Proteoglycans in cancer_Homo sapiens_hsa052050.45741502
107Hippo signaling pathway_Homo sapiens_hsa043900.45703856
108Carbon metabolism_Homo sapiens_hsa012000.45162805
109TNF signaling pathway_Homo sapiens_hsa046680.44081983
110Pentose phosphate pathway_Homo sapiens_hsa000300.43412930
111TGF-beta signaling pathway_Homo sapiens_hsa043500.43031892
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.42812801
113Platelet activation_Homo sapiens_hsa046110.42223399
114Basal cell carcinoma_Homo sapiens_hsa052170.41622318
115Tight junction_Homo sapiens_hsa045300.41480837
116Linoleic acid metabolism_Homo sapiens_hsa005910.40115943
117Asthma_Homo sapiens_hsa053100.39874137
118Allograft rejection_Homo sapiens_hsa053300.39086625
119HIF-1 signaling pathway_Homo sapiens_hsa040660.38536832
120Pathways in cancer_Homo sapiens_hsa052000.38157603
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37539534
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36988589
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.36015052
124Pertussis_Homo sapiens_hsa051330.35338395
125Pyruvate metabolism_Homo sapiens_hsa006200.34923674
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34229550
127Fat digestion and absorption_Homo sapiens_hsa049750.33788121
128Notch signaling pathway_Homo sapiens_hsa043300.33674339
129N-Glycan biosynthesis_Homo sapiens_hsa005100.33226657
130Fatty acid metabolism_Homo sapiens_hsa012120.32515800
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32473403
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32427522
133Tryptophan metabolism_Homo sapiens_hsa003800.32371445
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32192836
135Influenza A_Homo sapiens_hsa051640.31961884
136Phototransduction_Homo sapiens_hsa047440.29327203
137Retinol metabolism_Homo sapiens_hsa008300.28838254
138Serotonergic synapse_Homo sapiens_hsa047260.26592167
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26578277
140Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24436994
141Chemical carcinogenesis_Homo sapiens_hsa052040.22955364
142Peroxisome_Homo sapiens_hsa041460.22027771
143Caffeine metabolism_Homo sapiens_hsa002320.21773767
144Regulation of autophagy_Homo sapiens_hsa041400.21583950
145alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19742581
146SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16827811
147Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.15345137
148Primary bile acid biosynthesis_Homo sapiens_hsa001200.14131705
149Oocyte meiosis_Homo sapiens_hsa041140.13203076
150Steroid biosynthesis_Homo sapiens_hsa001000.12972102
151Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.12215910
152Sulfur metabolism_Homo sapiens_hsa009200.11816902
153Fatty acid elongation_Homo sapiens_hsa000620.11770141
154Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.11042133
155Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.10704617

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »