NSF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.72342490
2synaptic vesicle maturation (GO:0016188)5.92914787
3synaptic vesicle exocytosis (GO:0016079)5.89561583
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.78198006
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.66282639
6glutamate secretion (GO:0014047)5.65312479
7locomotory exploration behavior (GO:0035641)5.58042035
8vocalization behavior (GO:0071625)5.44426660
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.38956582
10regulation of synaptic vesicle exocytosis (GO:2000300)5.29815642
11synaptic vesicle docking involved in exocytosis (GO:0016081)5.26702246
12ionotropic glutamate receptor signaling pathway (GO:0035235)5.19744064
13regulation of glutamate receptor signaling pathway (GO:1900449)5.14366851
14protein localization to synapse (GO:0035418)4.93267388
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.82589291
16regulation of synaptic vesicle transport (GO:1902803)4.79523428
17synaptic transmission, glutamatergic (GO:0035249)4.72455610
18glutamate receptor signaling pathway (GO:0007215)4.68436503
19regulation of neuronal synaptic plasticity (GO:0048168)4.62364973
20neuronal action potential propagation (GO:0019227)4.58699821
21neurotransmitter secretion (GO:0007269)4.58555480
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.53333492
23exploration behavior (GO:0035640)4.50537691
24neuron-neuron synaptic transmission (GO:0007270)4.49525630
25potassium ion homeostasis (GO:0055075)4.36865270
26cellular potassium ion homeostasis (GO:0030007)4.35341061
27neuron cell-cell adhesion (GO:0007158)4.35229051
28neurotransmitter-gated ion channel clustering (GO:0072578)4.22450467
29negative regulation of dendrite morphogenesis (GO:0050774)4.21781812
30cerebellar granule cell differentiation (GO:0021707)4.20976113
31long-term memory (GO:0007616)4.19626812
32positive regulation of synapse maturation (GO:0090129)4.13428686
33L-amino acid import (GO:0043092)4.10344778
34gamma-aminobutyric acid signaling pathway (GO:0007214)4.06498016
35regulation of excitatory postsynaptic membrane potential (GO:0060079)4.03530690
36regulation of synapse structural plasticity (GO:0051823)4.00435324
37potassium ion import (GO:0010107)4.00347175
38gamma-aminobutyric acid transport (GO:0015812)4.00020588
39amino acid import (GO:0043090)3.92040298
40synaptic vesicle endocytosis (GO:0048488)3.91162881
41positive regulation of membrane potential (GO:0045838)3.90660173
42regulation of postsynaptic membrane potential (GO:0060078)3.85441970
43negative regulation of synaptic transmission, GABAergic (GO:0032229)3.82932161
44regulation of synaptic plasticity (GO:0048167)3.81592028
45regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.81557703
46long-term synaptic potentiation (GO:0060291)3.78857319
47neurotransmitter transport (GO:0006836)3.78349501
48proline transport (GO:0015824)3.76026926
49layer formation in cerebral cortex (GO:0021819)3.74525401
50sodium ion export (GO:0071436)3.74524090
51membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.73893262
52response to pheromone (GO:0019236)3.68031319
53G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.59477109
54presynaptic membrane organization (GO:0097090)3.59305579
55cerebellar Purkinje cell differentiation (GO:0021702)3.57517594
56vesicle docking involved in exocytosis (GO:0006904)3.56477231
57detection of calcium ion (GO:0005513)3.56228853
58regulation of neurotransmitter secretion (GO:0046928)3.56075191
59neuron recognition (GO:0008038)3.55944488
60presynaptic membrane assembly (GO:0097105)3.53660451
61regulation of dendritic spine morphogenesis (GO:0061001)3.52161663
62regulation of synaptic transmission, glutamatergic (GO:0051966)3.52081813
63neuromuscular process controlling posture (GO:0050884)3.49869072
64cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.48821120
65behavioral defense response (GO:0002209)3.48020005
66behavioral fear response (GO:0001662)3.48020005
67dendritic spine morphogenesis (GO:0060997)3.46937544
68regulation of neurotransmitter levels (GO:0001505)3.45539463
69transmission of nerve impulse (GO:0019226)3.45389110
70positive regulation of synaptic transmission, GABAergic (GO:0032230)3.45377208
71regulation of vesicle fusion (GO:0031338)3.43502648
72positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.42066964
73activation of protein kinase A activity (GO:0034199)3.40782856
74positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.39388347
75response to histamine (GO:0034776)3.38322648
76neurotransmitter uptake (GO:0001504)3.38019252
77vesicle docking (GO:0048278)3.37048080
78neuronal ion channel clustering (GO:0045161)3.35500618
79positive regulation of neurotransmitter secretion (GO:0001956)3.31878032
80membrane depolarization (GO:0051899)3.29315860
81innervation (GO:0060384)3.28194955
82regulation of voltage-gated calcium channel activity (GO:1901385)3.27952117
83regulation of neurotransmitter transport (GO:0051588)3.27116622
84positive regulation of neurotransmitter transport (GO:0051590)3.26802303
85membrane hyperpolarization (GO:0060081)3.26637436
86acidic amino acid transport (GO:0015800)3.25659394
87membrane depolarization during action potential (GO:0086010)3.25137014
88signal release (GO:0023061)3.24878676
89neuromuscular process controlling balance (GO:0050885)3.24679972
90cell communication by electrical coupling (GO:0010644)3.22506936
91fear response (GO:0042596)3.22145062
92vesicle transport along microtubule (GO:0047496)3.21519714
93regulation of synapse maturation (GO:0090128)3.18718007
94positive regulation of synaptic transmission (GO:0050806)3.18058003
95G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.16763726
96* synaptic transmission (GO:0007268)3.16165852
97dendritic spine organization (GO:0097061)3.14765880
98regulation of synaptic transmission (GO:0050804)3.14738477
99positive regulation of dendritic spine morphogenesis (GO:0061003)3.13786119
100axonal fasciculation (GO:0007413)3.12786588
101postsynaptic membrane organization (GO:0001941)3.12715299
102long term synaptic depression (GO:0060292)3.11378958
103learning (GO:0007612)3.11348075
104relaxation of cardiac muscle (GO:0055119)3.11042910
105negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.09251043
106regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.06997047
107cell communication involved in cardiac conduction (GO:0086065)3.04392429
108* regulation of exocytosis (GO:0017157)3.00089247
109glycine transport (GO:0015816)2.99199695
110cerebellar Purkinje cell layer development (GO:0021680)2.98970167
111regulation of dendritic spine development (GO:0060998)2.97928681
112positive regulation of dendritic spine development (GO:0060999)2.95774425
113positive regulation of exocytosis (GO:0045921)2.95770302
114positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.95747349
115cellular sodium ion homeostasis (GO:0006883)2.94513079
116chemosensory behavior (GO:0007635)2.94502811
117behavioral response to cocaine (GO:0048148)2.94284787
118neuromuscular process (GO:0050905)2.93554567
119regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.93209272
120synaptic vesicle transport (GO:0048489)2.93197253
121establishment of synaptic vesicle localization (GO:0097480)2.93197253
122serotonin metabolic process (GO:0042428)2.92012789
123establishment of vesicle localization (GO:0051650)2.90639794
124regulation of ARF protein signal transduction (GO:0032012)2.89801125
125positive regulation of vesicle fusion (GO:0031340)2.88628997
126axon ensheathment in central nervous system (GO:0032291)2.86882033
127central nervous system myelination (GO:0022010)2.86882033

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.52833004
2GBX2_23144817_ChIP-Seq_PC3_Human3.88661536
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.16396867
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10368559
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03594825
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.83671057
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.71388558
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.71388558
9* RARB_27405468_Chip-Seq_BRAIN_Mouse2.66629643
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64801469
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.64438722
12DROSHA_22980978_ChIP-Seq_HELA_Human2.62134967
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54810275
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50678229
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50491039
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37909071
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.36038754
18* REST_18959480_ChIP-ChIP_MESCs_Mouse2.33714184
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.30337948
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.29137790
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19962741
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.16427713
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.13844884
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.12525881
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99798212
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.96983598
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90251088
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.86624297
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85974814
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84684317
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.83401166
32SMAD4_21799915_ChIP-Seq_A2780_Human1.80491492
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.80335727
34TAF15_26573619_Chip-Seq_HEK293_Human1.78254229
35AR_21572438_ChIP-Seq_LNCaP_Human1.78129082
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75146772
37* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75131190
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49099318
39P300_19829295_ChIP-Seq_ESCs_Human1.47260393
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44164812
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.43692670
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.41712612
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41625975
44ZNF274_21170338_ChIP-Seq_K562_Hela1.38770707
45TET1_21490601_ChIP-Seq_MESCs_Mouse1.38103222
46SOX2_21211035_ChIP-Seq_LN229_Gbm1.35324268
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35073216
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34505906
49AR_25329375_ChIP-Seq_VCAP_Human1.34159549
50RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.31615137
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.31158884
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30579522
53STAT3_23295773_ChIP-Seq_U87_Human1.28465307
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28178520
55AR_19668381_ChIP-Seq_PC3_Human1.23984739
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.23213547
57* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20903128
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20557241
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17678627
60FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17609668
61DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17177499
62ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16799537
63E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16660807
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.14703282
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14629334
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.13656933
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13397555
68TCF4_23295773_ChIP-Seq_U87_Human1.13155954
69P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13016118
70PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11468045
71* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09335158
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08856555
73TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08449063
74IGF1R_20145208_ChIP-Seq_DFB_Human1.07896448
75YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07013031
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.05084826
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.04643918
78RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03497603
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03079308
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.03023302
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02558787
82FUS_26573619_Chip-Seq_HEK293_Human1.01888817
83RNF2_27304074_Chip-Seq_NSC_Mouse1.01679201
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01588927
85CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00266558
86RING1B_27294783_Chip-Seq_NPCs_Mouse1.00019446
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99772276
88* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99491467
89VDR_22108803_ChIP-Seq_LS180_Human0.98568006
90EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97616517
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97564380
92* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97178149
93SMAD3_21741376_ChIP-Seq_HESCs_Human0.96944489
94* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96507933
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96366500
96AHR_22903824_ChIP-Seq_MCF-7_Human0.96346113
97SOX9_26525672_Chip-Seq_HEART_Mouse0.96158743
98RUNX2_22187159_ChIP-Seq_PCA_Human0.95666698
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94597728
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94597728
101NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94221427
102SMAD3_21741376_ChIP-Seq_ESCs_Human0.94156848
103CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93869382
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93752692
105TP53_16413492_ChIP-PET_HCT116_Human0.93205507
106JUN_21703547_ChIP-Seq_K562_Human0.91859128
107KDM2B_26808549_Chip-Seq_K562_Human0.91571059
108* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91452911
109PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91450987
110SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91448992
111WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90981534
112SMAD4_21741376_ChIP-Seq_HESCs_Human0.90951315
113* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89560814
114ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89471154
115CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89103522
116RXR_22108803_ChIP-Seq_LS180_Human0.88647054
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86933287
118* REST_19997604_ChIP-ChIP_NEURONS_Mouse0.85021463
119* FLI1_21867929_ChIP-Seq_TH2_Mouse0.84454480

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.95884518
2MP0003880_abnormal_central_pattern5.43596760
3MP0003635_abnormal_synaptic_transmissio4.36112643
4MP0009745_abnormal_behavioral_response3.59323079
5MP0004270_analgesia3.52427381
6MP0002063_abnormal_learning/memory/cond3.44263188
7MP0002064_seizures3.38698683
8MP0009046_muscle_twitch3.31961348
9MP0001968_abnormal_touch/_nociception3.30398501
10MP0002572_abnormal_emotion/affect_behav2.90652691
11MP0002272_abnormal_nervous_system2.77181719
12MP0002736_abnormal_nociception_after2.64685747
13MP0002734_abnormal_mechanical_nocicepti2.58483376
14MP0001486_abnormal_startle_reflex2.54182641
15MP0002735_abnormal_chemical_nociception2.53362418
16MP0005423_abnormal_somatic_nervous2.52404917
17MP0001501_abnormal_sleep_pattern2.46432123
18MP0002822_catalepsy2.39790094
19MP0001440_abnormal_grooming_behavior2.19494955
20MP0002067_abnormal_sensory_capabilities2.09595518
21MP0002733_abnormal_thermal_nociception1.98464876
22MP0001970_abnormal_pain_threshold1.97021701
23MP0008569_lethality_at_weaning1.93613808
24MP0003329_amyloid_beta_deposits1.88984756
25MP0003787_abnormal_imprinting1.75997307
26MP0002184_abnormal_innervation1.75886131
27MP0004811_abnormal_neuron_physiology1.75473588
28MP0005646_abnormal_pituitary_gland1.70792157
29MP0004924_abnormal_behavior1.69702488
30MP0005386_behavior/neurological_phenoty1.69702488
31MP0001984_abnormal_olfaction1.69228377
32MP0002557_abnormal_social/conspecific_i1.69030920
33MP0009780_abnormal_chondrocyte_physiolo1.68955041
34MP0002909_abnormal_adrenal_gland1.64713512
35MP0001348_abnormal_lacrimal_gland1.61726898
36MP0003879_abnormal_hair_cell1.60069924
37MP0006276_abnormal_autonomic_nervous1.58416391
38MP0004858_abnormal_nervous_system1.57288410
39MP0000778_abnormal_nervous_system1.53666131
40MP0000955_abnormal_spinal_cord1.44923202
41MP0004147_increased_porphyrin_level1.42877744
42MP0002066_abnormal_motor_capabilities/c1.40318603
43MP0002882_abnormal_neuron_morphology1.39970587
44MP0003633_abnormal_nervous_system1.35077436
45MP0005551_abnormal_eye_electrophysiolog1.33618970
46MP0001502_abnormal_circadian_rhythm1.29853174
47MP0001529_abnormal_vocalization1.29819203
48MP0004142_abnormal_muscle_tone1.26586585
49MP0003122_maternal_imprinting1.26123885
50MP0001905_abnormal_dopamine_level1.24873306
51MP0004885_abnormal_endolymph1.24703621
52MP0001188_hyperpigmentation1.20176237
53MP0003121_genomic_imprinting1.19670277
54MP0003631_nervous_system_phenotype1.13203067
55MP0005645_abnormal_hypothalamus_physiol1.12537484
56MP0001986_abnormal_taste_sensitivity1.05036217
57MP0002229_neurodegeneration1.04869220
58MP0008872_abnormal_physiological_respon1.04314728
59MP0010386_abnormal_urinary_bladder1.02339295
60MP0002152_abnormal_brain_morphology1.02173354
61MP0008874_decreased_physiological_sensi0.98113367
62MP0002837_dystrophic_cardiac_calcinosis0.96173070
63MP0004145_abnormal_muscle_electrophysio0.95747323
64MP0001346_abnormal_lacrimal_gland0.95072298
65MP0002069_abnormal_eating/drinking_beha0.91557602
66MP0000751_myopathy0.91424974
67MP0003075_altered_response_to0.86876494
68MP0000604_amyloidosis0.86164630
69MP0002090_abnormal_vision0.83185451
70MP0004215_abnormal_myocardial_fiber0.82963968
71MP0000569_abnormal_digit_pigmentation0.81707529
72MP0001177_atelectasis0.81200034
73MP0005535_abnormal_body_temperature0.80311658
74MP0001963_abnormal_hearing_physiology0.79831606
75MP0000013_abnormal_adipose_tissue0.79743327
76MP0005394_taste/olfaction_phenotype0.79375109
77MP0005499_abnormal_olfactory_system0.79375109
78MP0003632_abnormal_nervous_system0.78123225
79MP0002876_abnormal_thyroid_physiology0.77722895
80MP0004484_altered_response_of0.76863826
81MP0004085_abnormal_heartbeat0.76563309
82MP0002752_abnormal_somatic_nervous0.75146098
83MP0004233_abnormal_muscle_weight0.75088105
84MP0005379_endocrine/exocrine_gland_phen0.73902965
85MP0003634_abnormal_glial_cell0.73586234
86MP0004742_abnormal_vestibular_system0.72116598
87MP0008961_abnormal_basal_metabolism0.69054300
88MP0000639_abnormal_adrenal_gland0.67986874
89MP0006072_abnormal_retinal_apoptosis0.67546505
90MP0003690_abnormal_glial_cell0.67023130
91MP0004510_myositis0.66338074
92MP0003123_paternal_imprinting0.66301337
93MP0010234_abnormal_vibrissa_follicle0.64779180
94MP0002638_abnormal_pupillary_reflex0.63695045
95MP0001664_abnormal_digestion0.62006087
96MP0003283_abnormal_digestive_organ0.60126591
97MP0005171_absent_coat_pigmentation0.58497449
98MP0000920_abnormal_myelination0.58356035
99MP0000631_abnormal_neuroendocrine_gland0.57499581
100MP0005623_abnormal_meninges_morphology0.54882135
101MP0004043_abnormal_pH_regulation0.54620252
102MP0005253_abnormal_eye_physiology0.54450887
103MP0003956_abnormal_body_size0.54167111
104MP0003172_abnormal_lysosome_physiology0.53316866
105MP0005167_abnormal_blood-brain_barrier0.52488790
106MP0001485_abnormal_pinna_reflex0.52019484
107MP0001943_abnormal_respiration0.51967096
108MP0008877_abnormal_DNA_methylation0.51101340
109MP0010769_abnormal_survival0.51032592
110MP0003646_muscle_fatigue0.51013161
111MP0005187_abnormal_penis_morphology0.49497131
112MP0003137_abnormal_impulse_conducting0.46310597
113MP0002082_postnatal_lethality0.46023864
114MP0010770_preweaning_lethality0.46023864
115MP0001299_abnormal_eye_distance/0.45858763
116MP0010768_mortality/aging0.45312759
117MP0006035_abnormal_mitochondrial_morpho0.43655154

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.90565408
2Myokymia (HP:0002411)6.89752063
3Focal seizures (HP:0007359)6.24293148
4Visual hallucinations (HP:0002367)5.77997791
5Epileptic encephalopathy (HP:0200134)5.34964442
6Febrile seizures (HP:0002373)5.15314713
7Atonic seizures (HP:0010819)5.14212180
8Progressive cerebellar ataxia (HP:0002073)4.83103959
9Absence seizures (HP:0002121)4.69587433
10Dialeptic seizures (HP:0011146)4.38694855
11Generalized tonic-clonic seizures (HP:0002069)4.24188029
12Action tremor (HP:0002345)3.89098946
13Gaze-evoked nystagmus (HP:0000640)3.60631845
14Supranuclear gaze palsy (HP:0000605)3.54267596
15Cerebral hypomyelination (HP:0006808)3.49105539
16Broad-based gait (HP:0002136)3.44344677
17Impaired vibration sensation in the lower limbs (HP:0002166)3.42271156
18Hyperventilation (HP:0002883)3.35969032
19Tetraplegia (HP:0002445)3.35863696
20Depression (HP:0000716)3.33067158
21Dysdiadochokinesis (HP:0002075)3.32729776
22Poor eye contact (HP:0000817)3.25441982
23Truncal ataxia (HP:0002078)3.21379744
24Ankle clonus (HP:0011448)3.16137697
25Dysmetria (HP:0001310)3.15492873
26Abnormal eating behavior (HP:0100738)3.12622429
27Urinary bladder sphincter dysfunction (HP:0002839)3.07351328
28Postural instability (HP:0002172)3.03328472
29Amblyopia (HP:0000646)3.03303410
30Abnormality of the lower motor neuron (HP:0002366)3.03017283
31Anxiety (HP:0000739)2.99915500
32Impaired social interactions (HP:0000735)2.98097002
33Abnormal social behavior (HP:0012433)2.98097002
34Genetic anticipation (HP:0003743)2.91047479
35Impaired smooth pursuit (HP:0007772)2.89562054
36Scanning speech (HP:0002168)2.84828157
37Diplopia (HP:0000651)2.79613253
38Abnormality of binocular vision (HP:0011514)2.79613253
39Mutism (HP:0002300)2.76959907
40Epileptiform EEG discharges (HP:0011182)2.76463952
41Spinal muscular atrophy (HP:0007269)2.73471244
42Akinesia (HP:0002304)2.71800661
43Mesomelia (HP:0003027)2.68155458
44Bradykinesia (HP:0002067)2.67494689
45Excessive salivation (HP:0003781)2.66774596
46Drooling (HP:0002307)2.66774596
47Dysmetric saccades (HP:0000641)2.66317956
48Absent speech (HP:0001344)2.65656381
49Hemiparesis (HP:0001269)2.61222753
50EEG with generalized epileptiform discharges (HP:0011198)2.59951316
51Abnormality of ocular smooth pursuit (HP:0000617)2.54610383
52Hemiplegia (HP:0002301)2.52260414
53Spastic gait (HP:0002064)2.50718459
54Hand muscle atrophy (HP:0009130)2.50184949
55Papilledema (HP:0001085)2.49853210
56Progressive inability to walk (HP:0002505)2.49061261
57Degeneration of the lateral corticospinal tracts (HP:0002314)2.48832036
58Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.48832036
59Urinary urgency (HP:0000012)2.47876320
60Clonus (HP:0002169)2.41599722
61Cerebral inclusion bodies (HP:0100314)2.40162290
62CNS hypomyelination (HP:0003429)2.39840991
63Inability to walk (HP:0002540)2.39325402
64Status epilepticus (HP:0002133)2.38477506
65Hypsarrhythmia (HP:0002521)2.37157258
66Ventricular fibrillation (HP:0001663)2.35300328
67Stereotypic behavior (HP:0000733)2.33420888
68Obstructive sleep apnea (HP:0002870)2.32238099
69Agnosia (HP:0010524)2.32048841
70Impaired vibratory sensation (HP:0002495)2.31397541
71Torticollis (HP:0000473)2.30980038
72Focal dystonia (HP:0004373)2.27962972
73Intention tremor (HP:0002080)2.27811624
74Generalized myoclonic seizures (HP:0002123)2.21967756
75Amyotrophic lateral sclerosis (HP:0007354)2.20390520
76Fetal akinesia sequence (HP:0001989)2.17970366
77Apathy (HP:0000741)2.17519311
78Neurofibrillary tangles (HP:0002185)2.16169215
79Pheochromocytoma (HP:0002666)2.13296719
80Sleep apnea (HP:0010535)2.13147541
81Termporal pattern (HP:0011008)2.12241401
82Insidious onset (HP:0003587)2.12241401
83Polyphagia (HP:0002591)2.11498493
84Spastic tetraplegia (HP:0002510)2.06773093
85Lower limb muscle weakness (HP:0007340)2.06554231
86Peripheral hypomyelination (HP:0007182)2.05932512
87Annular pancreas (HP:0001734)2.03704348
88Incomplete penetrance (HP:0003829)2.03475967
89Choreoathetosis (HP:0001266)2.02826246
90Delusions (HP:0000746)2.01006098
91Morphological abnormality of the pyramidal tract (HP:0002062)2.00232675
92Gait ataxia (HP:0002066)2.00047712
93Distal upper limb amyotrophy (HP:0007149)1.96952677
94Upper limb amyotrophy (HP:0009129)1.96952677
95Central scotoma (HP:0000603)1.96232560
96Diminished motivation (HP:0000745)1.96151152
97Craniofacial dystonia (HP:0012179)1.94732376
98Pointed chin (HP:0000307)1.94203492
99Increased circulating renin level (HP:0000848)1.93882894
100Spastic tetraparesis (HP:0001285)1.91470155
101Neuronal loss in central nervous system (HP:0002529)1.91286027
102Postural tremor (HP:0002174)1.89982131
103Rapidly progressive (HP:0003678)1.88779253
104Abnormal sex determination (HP:0012244)1.86965198
105Sex reversal (HP:0012245)1.86965198
106Psychosis (HP:0000709)1.86866811
107Muscular hypotonia of the trunk (HP:0008936)1.85531465
108Agitation (HP:0000713)1.85408674
109Blue irides (HP:0000635)1.85274645
110Rigidity (HP:0002063)1.85193137
111Abnormality of saccadic eye movements (HP:0000570)1.85179232
112Megalencephaly (HP:0001355)1.84266361
113Neuroendocrine neoplasm (HP:0100634)1.82299196
114Retinal dysplasia (HP:0007973)1.82129106
115Gait imbalance (HP:0002141)1.79305320
116Arthropathy (HP:0003040)1.79094905
117Limb dystonia (HP:0002451)1.78983753
118Abnormality of salivation (HP:0100755)1.78191206
119Protruding tongue (HP:0010808)1.77129239
120Lower limb asymmetry (HP:0100559)1.76604709
121Specific learning disability (HP:0001328)1.75723830
122Abnormality of the corticospinal tract (HP:0002492)1.75265959
123Testicular neoplasm (HP:0010788)1.75043229
124Hypoventilation (HP:0002791)1.74990897
125Horizontal nystagmus (HP:0000666)1.72441711
126Insomnia (HP:0100785)1.72232450
127Type II lissencephaly (HP:0007260)1.69399382
128Abnormality of macular pigmentation (HP:0008002)1.69188592
129Inappropriate behavior (HP:0000719)1.69082141
130Abnormal EKG (HP:0003115)1.68862468

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.13744608
2EPHA44.70097575
3MAP3K93.85096489
4MAP3K43.42612733
5MAP2K72.92535602
6MINK12.74669803
7MAP3K122.48412694
8DAPK22.32817534
9KSR22.30446262
10PAK62.26912244
11RIPK42.20622924
12MARK12.18563283
13MAP2K42.12717258
14CASK1.80037532
15KSR11.77552555
16CAMKK11.76043678
17ARAF1.74957751
18PRKD31.74585165
19NTRK21.73454782
20DAPK11.72291567
21PLK21.69592938
22MAP3K131.55688863
23PRPF4B1.55251477
24STK381.53965342
25NTRK11.52958030
26PNCK1.52799731
27CDK51.50568677
28GRK51.48501730
29CDK191.46861600
30TNIK1.33224709
31PRKCG1.30929377
32BCR1.13628519
33MAP3K21.12373048
34SIK21.11707640
35LIMK11.08746413
36MAPK131.06417608
37CAMK2A1.03876047
38CAMKK21.03299057
39PTK2B1.01873412
40CAMK11.01046607
41RAF10.98877506
42SGK2230.92195203
43SGK4940.92195203
44UHMK10.90474455
45CAMK2B0.89392271
46CDK180.89370338
47BMPR20.89265923
48CDK150.86488413
49CDK140.85178281
50BRSK10.83109942
51TYRO30.82762011
52SGK20.82698498
53PINK10.82576279
54TRIM280.82331126
55LATS20.81819215
56NME10.80660796
57FRK0.80043126
58FGFR20.78530485
59RET0.75751287
60CDK11A0.74806914
61TNK20.74439583
62NEK10.74310333
63PRKCH0.73764593
64DYRK1A0.72774966
65STK110.72255711
66LMTK20.71908061
67MAP3K10.71885482
68OXSR10.71806948
69PAK30.68588724
70PDK10.67915539
71SGK10.67889385
72SGK30.67746535
73TAOK10.67078042
74PHKG20.66810394
75PHKG10.66810394
76STK390.65910247
77MAP3K60.63098841
78TESK10.62055883
79CAMK2D0.60764885
80PDPK10.58332035
81CSNK1G20.54685199
82FGR0.54667144
83ALK0.54397186
84CAMK2G0.53772427
85BRAF0.53391238
86CSNK1A10.51012256
87AKT30.50937990
88MAP3K70.50704112
89TSSK60.49989439
90MARK20.49909638
91RIPK10.48740539
92CSNK1G30.48468245
93CAMK1G0.47821553
94SIK30.47193139
95MAP2K10.46983824
96RPS6KA30.46792938
97CCNB10.46491803
98CSNK1A1L0.45739348
99CDC42BPA0.43516095
100MAPK100.43384273
101PRKCZ0.43361689
102CSNK1E0.42872805
103ERBB30.42644078
104PRKG20.41382402
105CAMK40.39318461
106WNK10.39009357
107NEK60.38708900
108FYN0.37807131
109PKN10.36253302
110DAPK30.35093227
111MAPKAPK50.34672267
112CSNK1D0.33505968
113PRKACA0.33115910
114ROCK20.32696083
115PRKG10.32290244
116PRKCB0.32109411
117PRKCA0.31201109
118* PRKCE0.30888211
119MOS0.30430407
120PLK30.30284407
121SCYL20.29746156
122WNK30.28408109

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.04802106
2* Synaptic vesicle cycle_Homo sapiens_hsa047213.53949589
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.82618731
4Circadian entrainment_Homo sapiens_hsa047132.81215679
5Long-term potentiation_Homo sapiens_hsa047202.80166819
6Olfactory transduction_Homo sapiens_hsa047402.78749035
7* GABAergic synapse_Homo sapiens_hsa047272.70244504
8Glutamatergic synapse_Homo sapiens_hsa047242.61655963
9Morphine addiction_Homo sapiens_hsa050322.56038234
10Amphetamine addiction_Homo sapiens_hsa050312.51556142
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.26629979
12Salivary secretion_Homo sapiens_hsa049702.20408064
13Dopaminergic synapse_Homo sapiens_hsa047282.16479315
14Insulin secretion_Homo sapiens_hsa049112.06774255
15Collecting duct acid secretion_Homo sapiens_hsa049661.88864652
16Gastric acid secretion_Homo sapiens_hsa049711.88048514
17Taste transduction_Homo sapiens_hsa047421.87519380
18Cholinergic synapse_Homo sapiens_hsa047251.86268050
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.85216158
20Long-term depression_Homo sapiens_hsa047301.77403121
21Renin secretion_Homo sapiens_hsa049241.70509578
22Oxytocin signaling pathway_Homo sapiens_hsa049211.68072137
23Serotonergic synapse_Homo sapiens_hsa047261.63781612
24Calcium signaling pathway_Homo sapiens_hsa040201.62715535
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57408557
26Vitamin B6 metabolism_Homo sapiens_hsa007501.49085269
27Cocaine addiction_Homo sapiens_hsa050301.47255813
28GnRH signaling pathway_Homo sapiens_hsa049121.47005817
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46708337
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31888701
31cAMP signaling pathway_Homo sapiens_hsa040241.28699949
32Gap junction_Homo sapiens_hsa045401.25673868
33Phototransduction_Homo sapiens_hsa047441.23957662
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23195630
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22896713
36Type II diabetes mellitus_Homo sapiens_hsa049301.19690963
37* Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16565110
38Vibrio cholerae infection_Homo sapiens_hsa051101.12784646
39Estrogen signaling pathway_Homo sapiens_hsa049151.12420907
40Glioma_Homo sapiens_hsa052141.07809966
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06534323
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03931993
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02106006
44ErbB signaling pathway_Homo sapiens_hsa040120.97385859
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96652708
46Cardiac muscle contraction_Homo sapiens_hsa042600.93909659
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93772082
48Melanogenesis_Homo sapiens_hsa049160.93726036
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.90729840
50Oocyte meiosis_Homo sapiens_hsa041140.89197137
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87929880
52Axon guidance_Homo sapiens_hsa043600.86507763
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83031415
54Pancreatic secretion_Homo sapiens_hsa049720.82538176
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.77973461
56Dorso-ventral axis formation_Homo sapiens_hsa043200.76227382
57Thyroid hormone synthesis_Homo sapiens_hsa049180.74815724
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74484653
59Choline metabolism in cancer_Homo sapiens_hsa052310.74107700
60MAPK signaling pathway_Homo sapiens_hsa040100.67388315
61Dilated cardiomyopathy_Homo sapiens_hsa054140.63938661
62Nitrogen metabolism_Homo sapiens_hsa009100.62208345
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.60159676
64Glucagon signaling pathway_Homo sapiens_hsa049220.58897610
65Type I diabetes mellitus_Homo sapiens_hsa049400.58600273
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58542580
67VEGF signaling pathway_Homo sapiens_hsa043700.58506744
68Inositol phosphate metabolism_Homo sapiens_hsa005620.58158689
69Circadian rhythm_Homo sapiens_hsa047100.57211022
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55969397
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54137383
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52950408
73AMPK signaling pathway_Homo sapiens_hsa041520.52778519
74Ras signaling pathway_Homo sapiens_hsa040140.52603773
75Arginine and proline metabolism_Homo sapiens_hsa003300.52588136
76Mineral absorption_Homo sapiens_hsa049780.52563729
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51317332
78mTOR signaling pathway_Homo sapiens_hsa041500.50348963
79beta-Alanine metabolism_Homo sapiens_hsa004100.50044251
80Rap1 signaling pathway_Homo sapiens_hsa040150.47772500
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47229722
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.46143451
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45988086
84Arginine biosynthesis_Homo sapiens_hsa002200.44154597
85Endocytosis_Homo sapiens_hsa041440.43207642
86Regulation of autophagy_Homo sapiens_hsa041400.42426240
87African trypanosomiasis_Homo sapiens_hsa051430.41810422
88Alcoholism_Homo sapiens_hsa050340.41546887
89Alzheimers disease_Homo sapiens_hsa050100.41256309
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37838123
91Bile secretion_Homo sapiens_hsa049760.37803170
92Prion diseases_Homo sapiens_hsa050200.37347714
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37167497
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36275019
95Wnt signaling pathway_Homo sapiens_hsa043100.35477198
96Rheumatoid arthritis_Homo sapiens_hsa053230.35466364
97Non-small cell lung cancer_Homo sapiens_hsa052230.34920989
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34863428
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34438077
100Endometrial cancer_Homo sapiens_hsa052130.33781427
101Insulin signaling pathway_Homo sapiens_hsa049100.32418967
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31984525
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30315517
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29755848
105Fatty acid elongation_Homo sapiens_hsa000620.29333916
106Chemokine signaling pathway_Homo sapiens_hsa040620.29038242
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27874993
108Renal cell carcinoma_Homo sapiens_hsa052110.26334168
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26259802
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25852193
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25817781
112Fatty acid biosynthesis_Homo sapiens_hsa000610.25106689
113Butanoate metabolism_Homo sapiens_hsa006500.24011019
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22551156
115Oxidative phosphorylation_Homo sapiens_hsa001900.22028647
116Histidine metabolism_Homo sapiens_hsa003400.21955690
117Tight junction_Homo sapiens_hsa045300.18519074
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.16574195
119Biosynthesis of amino acids_Homo sapiens_hsa012300.14913679

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