NSFP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of isotype switching to IgG isotypes (GO:0048302)5.18958213
2regulation of B cell receptor signaling pathway (GO:0050855)4.91005863
3activated T cell proliferation (GO:0050798)4.76464892
4rRNA catabolic process (GO:0016075)4.63974431
5dosage compensation (GO:0007549)4.48770401
6establishment of protein localization to Golgi (GO:0072600)4.25138282
7protein K11-linked deubiquitination (GO:0035871)4.24177055
8neural tube formation (GO:0001841)4.23060970
9nuclear pore complex assembly (GO:0051292)4.18909656
10pyrimidine dimer repair (GO:0006290)4.18184818
11histone mRNA catabolic process (GO:0071044)4.16318480
12protein targeting to Golgi (GO:0000042)4.13315900
13phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.99118793
14positive regulation of gamma-delta T cell activation (GO:0046645)3.84401097
15retrograde transport, vesicle recycling within Golgi (GO:0000301)3.78871030
16interferon-gamma production (GO:0032609)3.74698633
17negative T cell selection (GO:0043383)3.72020751
18cellular response to ethanol (GO:0071361)3.68547121
19nuclear pore organization (GO:0006999)3.62605472
20pore complex assembly (GO:0046931)3.54576749
21positive regulation of isotype switching (GO:0045830)3.49886553
22positive regulation of granulocyte differentiation (GO:0030854)3.49678238
23negative thymic T cell selection (GO:0045060)3.47803817
24pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.40357662
25UMP biosynthetic process (GO:0006222)3.40357662
26pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.40357662
27UMP metabolic process (GO:0046049)3.40357662
28cytoplasmic mRNA processing body assembly (GO:0033962)3.38141763
29dopamine transport (GO:0015872)3.33975956
30hepatocyte apoptotic process (GO:0097284)3.33883411
31positive regulation of DNA recombination (GO:0045911)3.31632971
32monoubiquitinated protein deubiquitination (GO:0035520)3.27688092
33regulation of gamma-delta T cell differentiation (GO:0045586)3.25097977
34ncRNA catabolic process (GO:0034661)3.22569595
35negative regulation of B cell proliferation (GO:0030889)3.22332418
36regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.20807197
37mast cell activation involved in immune response (GO:0002279)3.17440664
38mast cell degranulation (GO:0043303)3.17440664
39protein localization to Golgi apparatus (GO:0034067)3.16009985
40cellular extravasation (GO:0045123)3.10574951
41regulation of germinal center formation (GO:0002634)3.09879802
42negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.09450431
43mast cell activation (GO:0045576)3.06298406
44RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.01774635
45peptidyl-lysine trimethylation (GO:0018023)2.97219284
46positive T cell selection (GO:0043368)2.96900779
47B cell receptor signaling pathway (GO:0050853)2.89896385
48positive regulation of defense response to virus by host (GO:0002230)2.89150368
49positive regulation of mRNA catabolic process (GO:0061014)2.88869940
50regulation of gamma-delta T cell activation (GO:0046643)2.88761421
51lens fiber cell development (GO:0070307)2.87981876
52leukotriene biosynthetic process (GO:0019370)2.87896525
53protein K48-linked deubiquitination (GO:0071108)2.86266411
54histone mRNA metabolic process (GO:0008334)2.84043634
55CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.77417066
56T-helper cell differentiation (GO:0042093)2.77417066
57positive regulation of protein import into nucleus, translocation (GO:0033160)2.77239664
58positive regulation of B cell mediated immunity (GO:0002714)2.74420862
59positive regulation of immunoglobulin mediated immune response (GO:0002891)2.74420862
60regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.73554467
61positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.73554467
62centriole replication (GO:0007099)2.72690257
63histone H3-K36 demethylation (GO:0070544)2.71333016
64regulation of protein glycosylation (GO:0060049)2.70225333
65histone H3-K4 trimethylation (GO:0080182)2.69447042
66interkinetic nuclear migration (GO:0022027)2.68282878
67regulation of mRNA catabolic process (GO:0061013)2.68245684
68ovulation from ovarian follicle (GO:0001542)2.68151437
69regulation of DNA endoreduplication (GO:0032875)2.67987627
70regulation of protein polyubiquitination (GO:1902914)2.65472452
71replicative senescence (GO:0090399)2.64737725
72DNA synthesis involved in DNA repair (GO:0000731)2.64239653
73positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.64084463
74protein targeting to vacuole (GO:0006623)2.63602972
75protein targeting to lysosome (GO:0006622)2.63602972
76establishment of protein localization to vacuole (GO:0072666)2.63602972
77I-kappaB phosphorylation (GO:0007252)2.63341840
78acrosome assembly (GO:0001675)2.63240230
79regulation of relaxation of muscle (GO:1901077)2.61513691
80protein K63-linked deubiquitination (GO:0070536)2.61091758
81positive regulation of B cell differentiation (GO:0045579)2.61083011
82pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.60982481
83intra-Golgi vesicle-mediated transport (GO:0006891)2.59686441
84positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.59524127
85protein prenylation (GO:0018342)2.56718077
86prenylation (GO:0097354)2.56718077
87positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.51613625
88cellular response to interleukin-15 (GO:0071350)2.50715104
89CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.50481647
90regulation of centriole replication (GO:0046599)2.47386723
91regulation of fibroblast apoptotic process (GO:2000269)2.46677918
92pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.46334293
93positive regulation of alpha-beta T cell proliferation (GO:0046641)2.45710271
94regulation of isotype switching (GO:0045191)2.45575992
95lymphocyte activation involved in immune response (GO:0002285)2.45003646
96positive regulation of mitotic sister chromatid separation (GO:1901970)2.44768859
97positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.44768859
98positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.44768859
99negative regulation of cell killing (GO:0031342)2.44393568
100negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.44393568

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.01795807
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.59225821
3IRF8_22096565_ChIP-ChIP_GC-B_Human2.88397041
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.87531496
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.66817685
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.55595969
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.54319381
8TAF15_26573619_Chip-Seq_HEK293_Human2.41024624
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.27714002
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.24895812
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.20326513
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.20161200
13IGF1R_20145208_ChIP-Seq_DFB_Human2.08584738
14RUNX_20019798_ChIP-Seq_JUKART_Human2.03766020
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.01300209
16GBX2_23144817_ChIP-Seq_PC3_Human2.00714596
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96350847
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.95228135
19FUS_26573619_Chip-Seq_HEK293_Human1.89612866
20E2F4_17652178_ChIP-ChIP_JURKAT_Human1.83325253
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.82964989
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.82646105
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.77091558
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.74147900
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.70195543
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66462838
27CBP_20019798_ChIP-Seq_JUKART_Human1.66333715
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.66333715
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66092595
30EZH2_27294783_Chip-Seq_NPCs_Mouse1.66050540
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.63721070
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61275591
33GATA3_26560356_Chip-Seq_TH2_Human1.60389142
34EWS_26573619_Chip-Seq_HEK293_Human1.58894446
35E2F7_22180533_ChIP-Seq_HELA_Human1.58428567
36MYB_26560356_Chip-Seq_TH2_Human1.57796097
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57313065
38ZNF274_21170338_ChIP-Seq_K562_Hela1.48820637
39ER_23166858_ChIP-Seq_MCF-7_Human1.47199494
40NFE2_27457419_Chip-Seq_LIVER_Mouse1.47037601
41CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.44815316
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.44036758
43RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.43454927
44NANOG_18555785_Chip-Seq_ESCs_Mouse1.43038752
45GATA1_22025678_ChIP-Seq_K562_Human1.39407659
46VDR_23849224_ChIP-Seq_CD4+_Human1.38613547
47GATA3_27048872_Chip-Seq_THYMUS_Human1.38460324
48CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.38156566
49P300_19829295_ChIP-Seq_ESCs_Human1.38064932
50E2F1_18555785_Chip-Seq_ESCs_Mouse1.35684687
51STAT3_23295773_ChIP-Seq_U87_Human1.35359705
52SMAD4_21799915_ChIP-Seq_A2780_Human1.33457512
53ELK1_19687146_ChIP-ChIP_HELA_Human1.32781932
54TCF4_23295773_ChIP-Seq_U87_Human1.32662167
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31407082
56CRX_20693478_ChIP-Seq_RETINA_Mouse1.30760294
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29123208
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28297057
59BCAT_22108803_ChIP-Seq_LS180_Human1.27661940
60EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27438925
61AR_21572438_ChIP-Seq_LNCaP_Human1.26964930
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26277838
63P53_22387025_ChIP-Seq_ESCs_Mouse1.25797448
64TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24334061
65FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24229697
66FLI1_21867929_ChIP-Seq_TH2_Mouse1.23926526
67KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23136092
68CMYC_18555785_Chip-Seq_ESCs_Mouse1.22847718
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22826094
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21914874
71P300_18555785_Chip-Seq_ESCs_Mouse1.20362071
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20282184
73OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20226191
74MYB_26560356_Chip-Seq_TH1_Human1.19527940
75VDR_22108803_ChIP-Seq_LS180_Human1.17718086
76STAT3_18555785_Chip-Seq_ESCs_Mouse1.17579541
77SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17224954
78NMYC_18555785_Chip-Seq_ESCs_Mouse1.16397680
79OCT4_18555785_Chip-Seq_ESCs_Mouse1.15135798
80SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.14958700
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14949798
82SOX2_18555785_Chip-Seq_ESCs_Mouse1.14063204
83IRF1_19129219_ChIP-ChIP_H3396_Human1.12400491
84PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09675426
85Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.08757610
86SALL4_22934838_ChIP-ChIP_CD34+_Human1.08294684
87MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.08165640
88FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05811128
89CDX2_22108803_ChIP-Seq_LS180_Human1.04195577
90KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.03959609
91IRF8_27001747_Chip-Seq_BMDM_Mouse1.03042082
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02853716
93SMAD1_18555785_Chip-Seq_ESCs_Mouse1.01559265
94EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00921201
95TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00250992
96MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98630022
97VDR_24787735_ChIP-Seq_THP-1_Human0.98074971
98CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96409028
99TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96261442
100PRDM14_20953172_ChIP-Seq_ESCs_Human0.96235840

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.79770488
2MP0008057_abnormal_DNA_replication4.30478634
3MP0006082_CNS_inflammation3.27524133
4MP0002132_abnormal_respiratory_system2.77620362
5MP0003763_abnormal_thymus_physiology2.69587373
6MP0001835_abnormal_antigen_presentation2.43918443
7MP0002009_preneoplasia2.35908279
8MP0002166_altered_tumor_susceptibility2.26479277
9MP0003656_abnormal_erythrocyte_physiolo2.22905637
10MP0000015_abnormal_ear_pigmentation2.21858197
11MP0005671_abnormal_response_to2.20854721
12MP0005408_hypopigmentation2.17313876
13MP0008058_abnormal_DNA_repair2.16201302
14MP0009697_abnormal_copulation2.13185238
15MP0003828_pulmonary_edema2.11088656
16MP0001800_abnormal_humoral_immune2.07194058
17MP0002405_respiratory_system_inflammati1.96676554
18MP0008877_abnormal_DNA_methylation1.92240964
19MP0010234_abnormal_vibrissa_follicle1.81806238
20MP0003252_abnormal_bile_duct1.78293493
21MP0003950_abnormal_plasma_membrane1.74127251
22MP0010094_abnormal_chromosome_stability1.71703600
23MP0003724_increased_susceptibility_to1.70540238
24MP0005000_abnormal_immune_tolerance1.65536961
25MP0010307_abnormal_tumor_latency1.62296962
26MP0005075_abnormal_melanosome_morpholog1.62227348
27MP0000465_gastrointestinal_hemorrhage1.52485132
28MP0003646_muscle_fatigue1.51943998
29MP0000685_abnormal_immune_system1.47517240
30MP0005310_abnormal_salivary_gland1.43681303
31MP0002452_abnormal_antigen_presenting1.43611909
32MP0005174_abnormal_tail_pigmentation1.42467807
33MP0002928_abnormal_bile_duct1.42029839
34MP0000749_muscle_degeneration1.41250808
35MP0002398_abnormal_bone_marrow1.40122110
36MP0002006_tumorigenesis1.38528357
37MP0002723_abnormal_immune_serum1.35220512
38MP0002420_abnormal_adaptive_immunity1.33877832
39MP0001819_abnormal_immune_cell1.31398249
40MP0003221_abnormal_cardiomyocyte_apopto1.30949162
41MP0001873_stomach_inflammation1.26303716
42MP0003787_abnormal_imprinting1.24829616
43MP0000689_abnormal_spleen_morphology1.23940629
44MP0009785_altered_susceptibility_to1.22152431
45MP0004084_abnormal_cardiac_muscle1.20873411
46MP0002396_abnormal_hematopoietic_system1.20564691
47MP0000716_abnormal_immune_system1.18426944
48MP0010352_gastrointestinal_tract_polyps1.17983840
49MP0000703_abnormal_thymus_morphology1.13858977
50MP0004808_abnormal_hematopoietic_stem1.11094519
51MP0000372_irregular_coat_pigmentation1.10312974
52MP0004036_abnormal_muscle_relaxation1.09921125
53MP0002332_abnormal_exercise_endurance1.08844890
54MP0002722_abnormal_immune_system1.08149204
55MP0003077_abnormal_cell_cycle1.08063786
56MP0008007_abnormal_cellular_replicative1.06570968
57MP0003866_abnormal_defecation1.04653614
58MP0002419_abnormal_innate_immunity1.03620236
59MP0005645_abnormal_hypothalamus_physiol1.03534274
60MP0000858_altered_metastatic_potential1.01290404
61MP0001845_abnormal_inflammatory_respons0.98180243
62MP0010155_abnormal_intestine_physiology0.97882334
63MP0005397_hematopoietic_system_phenotyp0.97755062
64MP0001545_abnormal_hematopoietic_system0.97755062
65MP0002019_abnormal_tumor_incidence0.97393668
66MP0000427_abnormal_hair_cycle0.96813980
67MP0003045_fibrosis0.96625232
68MP0003868_abnormal_feces_composition0.93241192
69MP0001853_heart_inflammation0.92474506
70MP0003690_abnormal_glial_cell0.91650676
71MP0002269_muscular_atrophy0.89790484
72MP0009764_decreased_sensitivity_to0.89340046
73MP0005025_abnormal_response_to0.88901421
74MP0002429_abnormal_blood_cell0.88241408
75MP0004883_abnormal_blood_vessel0.86158989
76MP0003718_maternal_effect0.85463498
77MP0006035_abnormal_mitochondrial_morpho0.83960998
78MP0000371_diluted_coat_color0.83070938
79MP0006072_abnormal_retinal_apoptosis0.81422487
80MP0010678_abnormal_skin_adnexa0.81414892
81MP0005266_abnormal_metabolism0.79715926
82MP0003786_premature_aging0.76708838
83MP0001984_abnormal_olfaction0.75438786
84MP0005410_abnormal_fertilization0.75346789
85MP0003633_abnormal_nervous_system0.73328897
86MP0002876_abnormal_thyroid_physiology0.73099098
87MP0005253_abnormal_eye_physiology0.71765531
88MP0005167_abnormal_blood-brain_barrier0.69812695
89MP0005647_abnormal_sex_gland0.69199512
90MP0008770_decreased_survivor_rate0.68248417
91MP0003195_calcinosis0.65988753
92MP0004142_abnormal_muscle_tone0.65590453
93MP0008469_abnormal_protein_level0.64181522
94MP0003631_nervous_system_phenotype0.64053030
95MP0005464_abnormal_platelet_physiology0.62462618
96MP0002148_abnormal_hypersensitivity_rea0.61793462
97MP0003300_gastrointestinal_ulcer0.61314771
98MP0004484_altered_response_of0.61019181
99MP0008873_increased_physiological_sensi0.58309999
100MP0002127_abnormal_cardiovascular_syste0.57675346

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.22060945
2Abnormality of pyrimidine metabolism (HP:0004353)3.97238189
3Thyroiditis (HP:0100646)3.68253783
4Spinal muscular atrophy (HP:0007269)3.50598753
5IgM deficiency (HP:0002850)3.45790892
6Thrombocytosis (HP:0001894)3.40054666
7Volvulus (HP:0002580)3.39493259
8Degeneration of anterior horn cells (HP:0002398)3.31030609
9Abnormality of the anterior horn cell (HP:0006802)3.31030609
10Fair hair (HP:0002286)3.27006369
11Stomach cancer (HP:0012126)3.22078816
12Abnormality of T cell number (HP:0011839)3.21008291
13T lymphocytopenia (HP:0005403)3.20461671
14Gaze-evoked nystagmus (HP:0000640)3.17640088
15Abnormality of T cell physiology (HP:0011840)3.12435018
16Abnormality of T cells (HP:0002843)3.10136923
17Prominent nose (HP:0000448)2.95367633
18Autoimmune hemolytic anemia (HP:0001890)2.90847105
19Renal cortical cysts (HP:0000803)2.85222796
20Facial diplegia (HP:0001349)2.81465926
21Severe combined immunodeficiency (HP:0004430)2.71372136
22Myositis (HP:0100614)2.69831383
23Cutaneous melanoma (HP:0012056)2.69816678
24IgG deficiency (HP:0004315)2.67432187
25Fatigue (HP:0012378)2.65322524
26Abnormality of chromosome stability (HP:0003220)2.62608275
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.60902609
28Generalized hypopigmentation of hair (HP:0011358)2.60202917
29Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.56075247
30Papillary thyroid carcinoma (HP:0002895)2.55918113
31Chromsome breakage (HP:0040012)2.54305390
32Chronic diarrhea (HP:0002028)2.51820272
33Chest pain (HP:0100749)2.37499511
34Tubulointerstitial nephritis (HP:0001970)2.37456028
35Abnormality of the prostate (HP:0008775)2.35276866
36Megaloblastic anemia (HP:0001889)2.30312711
37Recurrent bacterial skin infections (HP:0005406)2.28214350
38Abnormal hair whorl (HP:0010721)2.27102898
39Neoplasm of the tracheobronchial system (HP:0100552)2.26465015
40Hyperventilation (HP:0002883)2.25478402
41Acute hepatic failure (HP:0006554)2.25323644
42Thyroid carcinoma (HP:0002890)2.20905522
43Recurrent cutaneous fungal infections (HP:0011370)2.18316889
44Chronic mucocutaneous candidiasis (HP:0002728)2.18316889
45Acute myeloid leukemia (HP:0004808)2.15741920
46Abnormality of eosinophils (HP:0001879)2.15515117
47Combined immunodeficiency (HP:0005387)2.14182891
48IgA deficiency (HP:0002720)2.12798538
49Febrile seizures (HP:0002373)2.10753179
50Amaurosis fugax (HP:0100576)2.10173348
51Arterial thrombosis (HP:0004420)2.07196246
52Hypoplasia of the thymus (HP:0000778)2.07015024
53Poikilocytosis (HP:0004447)2.06894940
54Gastrointestinal infarctions (HP:0005244)2.05294926
55Albinism (HP:0001022)2.02483826
56Zonular cataract (HP:0010920)2.02408643
57Asthma (HP:0002099)1.99904127
58Progressive inability to walk (HP:0002505)1.98607957
59Prostate neoplasm (HP:0100787)1.97358860
60Recurrent fungal infections (HP:0002841)1.96692575
61Leukocytosis (HP:0001974)1.96641843
62Hypoproteinemia (HP:0003075)1.94961040
63Cerebellar dysplasia (HP:0007033)1.94513589
64Abnormality of the renal cortex (HP:0011035)1.93931729
65Erythema (HP:0010783)1.93061007
66Myelodysplasia (HP:0002863)1.91262401
67Subacute progressive viral hepatitis (HP:0006572)1.90623658
68Atrophy/Degeneration involving motor neurons (HP:0007373)1.89793846
69Hip dysplasia (HP:0001385)1.89724731
70Protruding tongue (HP:0010808)1.87896282
71Menstrual irregularities (HP:0000858)1.84892316
72Heterotopia (HP:0002282)1.84523290
73Ectropion (HP:0000656)1.84350003
74Recurrent bronchitis (HP:0002837)1.83004226
75Abnormal spermatogenesis (HP:0008669)1.82170958
76Nasal polyposis (HP:0100582)1.80967776
773-Methylglutaconic aciduria (HP:0003535)1.80709116
78Alveolar cell carcinoma (HP:0006519)1.79885224
79Neonatal respiratory distress (HP:0002643)1.79169060
80Abnormality of B cell number (HP:0010975)1.78712732
81Eosinophilia (HP:0001880)1.76532209
82Glucose intolerance (HP:0000833)1.76356319
83Hypsarrhythmia (HP:0002521)1.76081460
84Gingival bleeding (HP:0000225)1.75364804
85Truncal obesity (HP:0001956)1.73602858
86Interstitial pulmonary disease (HP:0006530)1.72611087
87Hypothermia (HP:0002045)1.72541654
88Attenuation of retinal blood vessels (HP:0007843)1.69482700
89Clubbing of toes (HP:0100760)1.67207294
90Inability to walk (HP:0002540)1.66847710
91EEG with generalized epileptiform discharges (HP:0011198)1.65803615
92Chronic hepatic failure (HP:0100626)1.65365717
93Hypoplastic iliac wings (HP:0002866)1.65295401
94Aplasia/Hypoplasia of the uvula (HP:0010293)1.64474442
95Abnormality of the fingertips (HP:0001211)1.63576127
96Epileptiform EEG discharges (HP:0011182)1.61861222
97Recurrent skin infections (HP:0001581)1.61673762
98Metaphyseal dysplasia (HP:0100255)1.59621488
99Conjugated hyperbilirubinemia (HP:0002908)1.59558492
100Retrobulbar optic neuritis (HP:0100654)1.59176920

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.10094811
2EIF2AK32.97813081
3ITK2.94650191
4TAOK32.84806485
5STK392.83999739
6BMPR22.22780436
7PIK3CG2.10008182
8MAP3K122.09667007
9MAP3K142.06770396
10MAP4K22.01768644
11TXK1.93614547
12TEC1.83063546
13PTK2B1.77786098
14ZAP701.75119291
15BRD41.66827998
16FES1.66735242
17ZAK1.64608572
18ERBB31.58527448
19JAK11.57367720
20BLK1.57276197
21TRPM71.56400262
22WNK11.52777776
23OBSCN1.52706490
24WNK41.50476068
25BTK1.47281876
26OXSR11.45084786
27MAP3K41.41014494
28PDK21.40688227
29AKT31.40535608
30SCYL21.33104326
31PIM11.29563044
32BRSK21.27194268
33SYK1.25986729
34CDK121.24304105
35GRK61.21453002
36CAMKK21.19460788
37MST41.18837140
38ADRBK21.09004202
39TLK11.04384830
40BMPR1B1.00786299
41TRIM280.99212334
42PLK20.96064839
43JAK30.88281663
44IKBKE0.84542847
45FER0.84010410
46NEK60.83845893
47DYRK30.82813159
48LCK0.79531329
49TBK10.79170405
50MAPK70.78653305
51CASK0.74679536
52PLK40.73898685
53LYN0.73383724
54MAP3K70.71619392
55FGFR30.70977854
56HCK0.70822368
57ATM0.69539541
58RPS6KA40.68659654
59IKBKB0.66331871
60PDGFRB0.65032475
61DYRK1A0.62427171
62CCNB10.60388579
63STK38L0.59145156
64MAP2K20.58541511
65JAK20.58501533
66CHEK20.58349246
67RPS6KA50.55740887
68TNIK0.54462442
69SGK20.54364640
70CSF1R0.53591004
71IGF1R0.53341803
72ATR0.52868340
73PAK30.52196284
74PRKACB0.51110722
75EGFR0.50972211
76ACVR1B0.50520683
77SRPK10.50050276
78KIT0.49848279
79PINK10.49697466
80CDK40.49609523
81FLT30.48398671
82CAMK1G0.48083510
83NUAK10.47702834
84TYK20.47125610
85MAPK110.45807993
86CSK0.44868722
87MAP4K10.43968931
88MAP2K40.43777196
89CAMK40.41774840
90CHEK10.39876839
91MUSK0.38406099
92MKNK20.38373375
93FGR0.38188764
94CSNK1A1L0.37828151
95MARK30.37580764
96NEK90.37146777
97EIF2AK10.36097221
98GSK3A0.36004679
99CSNK1D0.35967954
100PRKCE0.35880495

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053322.95747919
2Non-homologous end-joining_Homo sapiens_hsa034502.93491747
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.39423639
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.39296255
5Primary immunodeficiency_Homo sapiens_hsa053402.17905317
6Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.15115891
7RNA degradation_Homo sapiens_hsa030182.13798947
8Fanconi anemia pathway_Homo sapiens_hsa034602.07900440
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.04418624
10T cell receptor signaling pathway_Homo sapiens_hsa046601.95759802
11Systemic lupus erythematosus_Homo sapiens_hsa053221.90667000
12Basal transcription factors_Homo sapiens_hsa030221.90371361
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.80241650
14Type I diabetes mellitus_Homo sapiens_hsa049401.72198458
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.67392295
16Legionellosis_Homo sapiens_hsa051341.66900197
17Measles_Homo sapiens_hsa051621.66719434
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.63751758
19Antigen processing and presentation_Homo sapiens_hsa046121.60073506
20Autoimmune thyroid disease_Homo sapiens_hsa053201.57429907
21Leishmaniasis_Homo sapiens_hsa051401.57005023
22Regulation of autophagy_Homo sapiens_hsa041401.52106764
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.51933263
24Allograft rejection_Homo sapiens_hsa053301.49266833
25Protein export_Homo sapiens_hsa030601.49051814
26Viral myocarditis_Homo sapiens_hsa054161.49018453
27Homologous recombination_Homo sapiens_hsa034401.41708578
28B cell receptor signaling pathway_Homo sapiens_hsa046621.38714750
29Asthma_Homo sapiens_hsa053101.37183421
30Hematopoietic cell lineage_Homo sapiens_hsa046401.30327419
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27151681
32Circadian rhythm_Homo sapiens_hsa047101.26721686
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.26388986
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.25397983
35Spliceosome_Homo sapiens_hsa030401.22045154
36Olfactory transduction_Homo sapiens_hsa047401.21347874
37RNA transport_Homo sapiens_hsa030131.20102785
38Phototransduction_Homo sapiens_hsa047441.18646421
39Herpes simplex infection_Homo sapiens_hsa051681.15909883
40Selenocompound metabolism_Homo sapiens_hsa004501.14238456
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.11568753
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10991376
43Dorso-ventral axis formation_Homo sapiens_hsa043201.07866356
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.06593852
45Osteoclast differentiation_Homo sapiens_hsa043801.01785104
46Platelet activation_Homo sapiens_hsa046111.01095682
47Staphylococcus aureus infection_Homo sapiens_hsa051501.00822888
48Inositol phosphate metabolism_Homo sapiens_hsa005621.00262820
49Tuberculosis_Homo sapiens_hsa051520.97688554
50Toxoplasmosis_Homo sapiens_hsa051450.97214656
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96072616
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93390779
53Influenza A_Homo sapiens_hsa051640.89739563
54TNF signaling pathway_Homo sapiens_hsa046680.89470549
55Apoptosis_Homo sapiens_hsa042100.87513236
56mRNA surveillance pathway_Homo sapiens_hsa030150.85117666
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.85045235
58FoxO signaling pathway_Homo sapiens_hsa040680.83316568
59Nucleotide excision repair_Homo sapiens_hsa034200.83025362
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81399701
61Oocyte meiosis_Homo sapiens_hsa041140.80937892
62Hepatitis B_Homo sapiens_hsa051610.79744292
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75982821
64Viral carcinogenesis_Homo sapiens_hsa052030.71779915
65Rheumatoid arthritis_Homo sapiens_hsa053230.70957892
66Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68345584
67Alcoholism_Homo sapiens_hsa050340.62724328
68Ether lipid metabolism_Homo sapiens_hsa005650.62108350
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60388100
70Base excision repair_Homo sapiens_hsa034100.59617727
71p53 signaling pathway_Homo sapiens_hsa041150.57980417
72Non-small cell lung cancer_Homo sapiens_hsa052230.57960298
73ABC transporters_Homo sapiens_hsa020100.56783379
74Epstein-Barr virus infection_Homo sapiens_hsa051690.55275278
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.52493383
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52403189
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52237538
78MicroRNAs in cancer_Homo sapiens_hsa052060.48786190
79mTOR signaling pathway_Homo sapiens_hsa041500.48778826
80Mismatch repair_Homo sapiens_hsa034300.48503742
81Insulin resistance_Homo sapiens_hsa049310.46685564
82RNA polymerase_Homo sapiens_hsa030200.46182770
83Prolactin signaling pathway_Homo sapiens_hsa049170.46061111
84Propanoate metabolism_Homo sapiens_hsa006400.45105530
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44577596
86Purine metabolism_Homo sapiens_hsa002300.43412993
87Pyrimidine metabolism_Homo sapiens_hsa002400.43246265
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42527455
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42088731
90Chemokine signaling pathway_Homo sapiens_hsa040620.39374039
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38540137
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.38344474
93Lysine degradation_Homo sapiens_hsa003100.34795392
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33661283
95Colorectal cancer_Homo sapiens_hsa052100.32952944
96Malaria_Homo sapiens_hsa051440.32951208
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32651729
98Choline metabolism in cancer_Homo sapiens_hsa052310.31928699
99HIF-1 signaling pathway_Homo sapiens_hsa040660.30869702
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.30588626

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