NSG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.71672163
2synaptic vesicle maturation (GO:0016188)5.57939060
3vocalization behavior (GO:0071625)5.52387371
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.42305534
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.37152808
6locomotory exploration behavior (GO:0035641)5.36682197
7synaptic vesicle exocytosis (GO:0016079)5.15365392
8neuron cell-cell adhesion (GO:0007158)5.11778723
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.11004927
10layer formation in cerebral cortex (GO:0021819)4.93206120
11regulation of synaptic vesicle exocytosis (GO:2000300)4.86072115
12regulation of glutamate receptor signaling pathway (GO:1900449)4.85800437
13glutamate secretion (GO:0014047)4.80486685
14neurofilament cytoskeleton organization (GO:0060052)4.75504698
15protein localization to synapse (GO:0035418)4.74846606
16establishment of mitochondrion localization (GO:0051654)4.74551317
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.52534523
18exploration behavior (GO:0035640)4.51983741
19neurotransmitter secretion (GO:0007269)4.51738943
20regulation of synapse structural plasticity (GO:0051823)4.50861602
21behavioral response to nicotine (GO:0035095)4.32902671
22regulation of synaptic vesicle transport (GO:1902803)4.24231447
23synaptic vesicle docking involved in exocytosis (GO:0016081)4.23976058
24gamma-aminobutyric acid transport (GO:0015812)4.15395446
25glutamate receptor signaling pathway (GO:0007215)4.14996055
26neuron recognition (GO:0008038)4.11985266
27dendritic spine morphogenesis (GO:0060997)4.10318495
28pyrimidine nucleobase catabolic process (GO:0006208)4.06829107
29synaptic transmission, glutamatergic (GO:0035249)4.06005352
30regulation of long-term neuronal synaptic plasticity (GO:0048169)4.01591423
31neurotransmitter-gated ion channel clustering (GO:0072578)3.97349767
32neuronal action potential propagation (GO:0019227)3.97173510
33positive regulation of synapse maturation (GO:0090129)3.96760717
34proline transport (GO:0015824)3.91035913
35regulation of neuronal synaptic plasticity (GO:0048168)3.90662845
36axonal fasciculation (GO:0007413)3.90350230
37cell migration in hindbrain (GO:0021535)3.89393209
38neuron-neuron synaptic transmission (GO:0007270)3.88847463
39regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.86887311
40dendrite morphogenesis (GO:0048813)3.86460464
41postsynaptic membrane organization (GO:0001941)3.80902423
42cerebellar granule cell differentiation (GO:0021707)3.78494559
43negative regulation of microtubule polymerization (GO:0031115)3.73034129
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.70895300
45activation of protein kinase A activity (GO:0034199)3.70753138
46response to pheromone (GO:0019236)3.69589789
47mitochondrion transport along microtubule (GO:0047497)3.66220705
48establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.66220705
49cerebellar Purkinje cell differentiation (GO:0021702)3.63972237
50long-term memory (GO:0007616)3.63364227
51neurotransmitter transport (GO:0006836)3.62656255
52short-term memory (GO:0007614)3.61079869
53auditory behavior (GO:0031223)3.59052137
54regulation of excitatory postsynaptic membrane potential (GO:0060079)3.51234771
55transmission of nerve impulse (GO:0019226)3.48565381
56cellular potassium ion homeostasis (GO:0030007)3.43389890
57positive regulation of membrane potential (GO:0045838)3.43344277
58positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.41824881
59nucleobase catabolic process (GO:0046113)3.41586267
60regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.40627657
61G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.40577133
62prepulse inhibition (GO:0060134)3.37838159
63regulation of neurotransmitter levels (GO:0001505)3.36952942
64regulation of postsynaptic membrane potential (GO:0060078)3.36245852
65gamma-aminobutyric acid signaling pathway (GO:0007214)3.36103519
66regulation of neurotransmitter secretion (GO:0046928)3.35439692
67regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.32323311
68synapse assembly (GO:0007416)3.32266135
69positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.32068110
70neuromuscular process controlling balance (GO:0050885)3.29927397
71response to auditory stimulus (GO:0010996)3.29185244
72central nervous system projection neuron axonogenesis (GO:0021952)3.27921133
73regulation of dendritic spine morphogenesis (GO:0061001)3.27011286
74adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.23784517
75regulation of synaptic transmission, glutamatergic (GO:0051966)3.23161108
76positive regulation of synaptic transmission, GABAergic (GO:0032230)3.21414221
77regulation of vesicle fusion (GO:0031338)3.21399513
78synaptic vesicle endocytosis (GO:0048488)3.17653659
79regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.17128787
80neuromuscular synaptic transmission (GO:0007274)3.17092912
81neuronal ion channel clustering (GO:0045161)3.15515243
82axon extension (GO:0048675)3.15320564
83positive regulation of synapse assembly (GO:0051965)3.15047346
84presynaptic membrane assembly (GO:0097105)3.14874011
85regulation of synaptic plasticity (GO:0048167)3.14600697
86sodium ion export (GO:0071436)3.14344722
87negative regulation of synaptic transmission, GABAergic (GO:0032229)3.14238848
88presynaptic membrane organization (GO:0097090)3.13564368
89regulation of neurotransmitter transport (GO:0051588)3.13491342
90regulation of synapse maturation (GO:0090128)3.12434217
91positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.06989874
92mating behavior (GO:0007617)3.06013648
93cell differentiation in hindbrain (GO:0021533)3.03976698
94cell communication by electrical coupling (GO:0010644)3.03265977
95cerebellar Purkinje cell layer development (GO:0021680)3.02554289
96positive regulation of dendritic spine development (GO:0060999)3.01806326
97organelle transport along microtubule (GO:0072384)3.00500661
98membrane depolarization (GO:0051899)3.00475732
99long-term synaptic potentiation (GO:0060291)3.00114209
100membrane depolarization during action potential (GO:0086010)2.99674056
101mechanosensory behavior (GO:0007638)2.99561524
102intraspecies interaction between organisms (GO:0051703)2.99336802
103social behavior (GO:0035176)2.99336802
104positive regulation of dendritic spine morphogenesis (GO:0061003)2.98063590
105neuromuscular process controlling posture (GO:0050884)2.97288511
106synapse organization (GO:0050808)2.96755666
107negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.96115411
108substrate-independent telencephalic tangential migration (GO:0021826)2.95306123
109substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.95306123
110membrane hyperpolarization (GO:0060081)2.95305934
111adult walking behavior (GO:0007628)2.94916918
112learning (GO:0007612)2.94778308
113glycosphingolipid biosynthetic process (GO:0006688)2.91446112
114cerebral cortex radially oriented cell migration (GO:0021799)2.88967649
115synaptic transmission, cholinergic (GO:0007271)2.88642185
116retinal ganglion cell axon guidance (GO:0031290)2.85825337
117regulation of dopamine secretion (GO:0014059)2.84939382
118dendritic spine organization (GO:0097061)2.82048362
119hippocampus development (GO:0021766)2.82009526
120positive regulation of action potential (GO:0045760)2.79935607
121adult behavior (GO:0030534)2.78161347
122positive regulation of potassium ion transmembrane transport (GO:1901381)2.77031091
123startle response (GO:0001964)2.76967304
124regulation of synapse assembly (GO:0051963)2.76964663
125dendrite development (GO:0016358)2.72704227
126synaptic transmission (GO:0007268)2.72117030
127regulation of feeding behavior (GO:0060259)2.72104522
128neuron projection extension (GO:1990138)2.71374892
129regulation of synaptic transmission, GABAergic (GO:0032228)2.70433580

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.30711888
2GBX2_23144817_ChIP-Seq_PC3_Human3.44595643
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15706578
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10513743
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.10280317
6REST_21632747_ChIP-Seq_MESCs_Mouse2.84013251
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.79378101
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.79378101
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.68935622
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.68801714
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60910438
12* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58944622
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.58011688
14* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.56055218
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.54475908
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51785172
17DROSHA_22980978_ChIP-Seq_HELA_Human2.45470927
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.42958143
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.40275503
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.39103029
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.38537462
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33063528
23* REST_18959480_ChIP-ChIP_MESCs_Mouse2.31282897
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.22645104
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.11297139
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08088552
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.96548503
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90435108
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90187761
30AR_21572438_ChIP-Seq_LNCaP_Human1.83359695
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80828072
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75681939
33TAF15_26573619_Chip-Seq_HEK293_Human1.75368924
34VDR_22108803_ChIP-Seq_LS180_Human1.75262793
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.64737815
36ZNF274_21170338_ChIP-Seq_K562_Hela1.64399303
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61601867
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.61026293
39SMAD4_21799915_ChIP-Seq_A2780_Human1.53404907
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50711630
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50503526
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.46493592
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45818761
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43240780
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42733201
46RING1B_27294783_Chip-Seq_ESCs_Mouse1.42045439
47FUS_26573619_Chip-Seq_HEK293_Human1.39370407
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37443654
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32588700
50RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30960207
51RNF2_27304074_Chip-Seq_NSC_Mouse1.30480052
52P300_19829295_ChIP-Seq_ESCs_Human1.29383934
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.29272764
54IGF1R_20145208_ChIP-Seq_DFB_Human1.26690455
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22967253
56* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22407728
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.22269903
58RING1B_27294783_Chip-Seq_NPCs_Mouse1.22084738
59DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19314078
60AR_19668381_ChIP-Seq_PC3_Human1.18163295
61GATA1_26923725_Chip-Seq_HPCs_Mouse1.16867929
62AR_25329375_ChIP-Seq_VCAP_Human1.16320875
63ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15807825
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13465255
65* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13255287
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11885934
67* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11024992
68STAT3_23295773_ChIP-Seq_U87_Human1.09469081
69KDM2B_26808549_Chip-Seq_K562_Human1.09322061
70ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07994197
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06587539
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.06069790
73P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05417210
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04593094
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04506128
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04157440
77MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03031277
78* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02879834
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02334263
80EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01690803
81ARNT_22903824_ChIP-Seq_MCF-7_Human0.99591697
82TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98532838
83* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98380754
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98347544
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98180529
86CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97759899
87SMAD3_21741376_ChIP-Seq_ESCs_Human0.97619807
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97612407
89POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97601879
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96796546
91RUNX2_22187159_ChIP-Seq_PCA_Human0.96329534
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95890026
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95890026
94TCF4_23295773_ChIP-Seq_U87_Human0.95832821
95BCAT_22108803_ChIP-Seq_LS180_Human0.95740093
96* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94406568
97AHR_22903824_ChIP-Seq_MCF-7_Human0.94180464
98NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93268643
99* TAL1_26923725_Chip-Seq_HPCs_Mouse0.93081130
100SMAD4_21741376_ChIP-Seq_HESCs_Human0.92891468
101EWS_26573619_Chip-Seq_HEK293_Human0.92766988
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92539069
103ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91578516
104CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91117073
105CBP_20019798_ChIP-Seq_JUKART_Human0.90150909
106IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90150909
107PRDM14_20953172_ChIP-Seq_ESCs_Human0.88862903
108RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88544500
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88460895
110JUN_21703547_ChIP-Seq_K562_Human0.88048915
111POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87944618
112SMAD_19615063_ChIP-ChIP_OVARY_Human0.87936605
113OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87504498
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85701077
115NANOG_18555785_Chip-Seq_ESCs_Mouse0.85691795
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85626359
117STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.85197877
118* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84832914
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.84717624
120ER_23166858_ChIP-Seq_MCF-7_Human0.84322763
121TP53_22573176_ChIP-Seq_HFKS_Human0.83841693
122TET1_21490601_ChIP-Seq_MESCs_Mouse0.81803861
123CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.80297998

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.81295992
2MP0003880_abnormal_central_pattern4.43721367
3MP0003635_abnormal_synaptic_transmissio4.07922129
4MP0004270_analgesia3.54197336
5MP0002063_abnormal_learning/memory/cond3.28865775
6MP0009745_abnormal_behavioral_response3.26695636
7MP0005423_abnormal_somatic_nervous3.24150603
8MP0009046_muscle_twitch3.23664788
9MP0002064_seizures2.99879151
10MP0002734_abnormal_mechanical_nocicepti2.79350563
11MP0001968_abnormal_touch/_nociception2.79244709
12MP0002572_abnormal_emotion/affect_behav2.76566074
13MP0002822_catalepsy2.71371947
14MP0001984_abnormal_olfaction2.69991193
15MP0002272_abnormal_nervous_system2.47449687
16MP0001486_abnormal_startle_reflex2.46789922
17MP0001440_abnormal_grooming_behavior2.32629091
18MP0000778_abnormal_nervous_system2.32028879
19MP0002184_abnormal_innervation2.29864162
20MP0002733_abnormal_thermal_nociception2.18475196
21MP0002735_abnormal_chemical_nociception2.14315752
22MP0002736_abnormal_nociception_after2.12216014
23MP0006276_abnormal_autonomic_nervous2.11729128
24MP0002067_abnormal_sensory_capabilities2.05071287
25MP0001501_abnormal_sleep_pattern2.04648648
26MP0001970_abnormal_pain_threshold2.02822223
27MP0002557_abnormal_social/conspecific_i1.97894826
28MP0003121_genomic_imprinting1.95344047
29MP0008569_lethality_at_weaning1.93244335
30MP0004924_abnormal_behavior1.92642844
31MP0005386_behavior/neurological_phenoty1.92642844
32MP0004811_abnormal_neuron_physiology1.86533245
33MP0003329_amyloid_beta_deposits1.82487655
34MP0004858_abnormal_nervous_system1.78076827
35MP0000955_abnormal_spinal_cord1.71412616
36MP0009780_abnormal_chondrocyte_physiolo1.70721499
37MP0002909_abnormal_adrenal_gland1.66742865
38MP0001529_abnormal_vocalization1.62064175
39MP0002882_abnormal_neuron_morphology1.54832012
40MP0002066_abnormal_motor_capabilities/c1.47713221
41MP0005646_abnormal_pituitary_gland1.46694714
42MP0008877_abnormal_DNA_methylation1.44324268
43MP0005645_abnormal_hypothalamus_physiol1.43822548
44MP0003122_maternal_imprinting1.43749007
45MP0004885_abnormal_endolymph1.42394472
46MP0004142_abnormal_muscle_tone1.41729926
47MP0003787_abnormal_imprinting1.31264850
48MP0001905_abnormal_dopamine_level1.31090401
49MP0002152_abnormal_brain_morphology1.30657824
50MP0003879_abnormal_hair_cell1.28675098
51MP0001188_hyperpigmentation1.19096280
52MP0001502_abnormal_circadian_rhythm1.19013705
53MP0005499_abnormal_olfactory_system1.14983049
54MP0005394_taste/olfaction_phenotype1.14983049
55MP0003633_abnormal_nervous_system1.14483888
56MP0001986_abnormal_taste_sensitivity1.12859863
57MP0004742_abnormal_vestibular_system1.11346287
58MP0000569_abnormal_digit_pigmentation1.10714821
59MP0003011_delayed_dark_adaptation1.07798129
60MP0000751_myopathy1.06300898
61MP0003631_nervous_system_phenotype1.04131837
62MP0004145_abnormal_muscle_electrophysio1.03469160
63MP0002653_abnormal_ependyma_morphology1.01112926
64MP0004133_heterotaxia0.98220335
65MP0000631_abnormal_neuroendocrine_gland0.95565032
66MP0002752_abnormal_somatic_nervous0.93557814
67MP0002069_abnormal_eating/drinking_beha0.93511226
68MP0010386_abnormal_urinary_bladder0.93177020
69MP0002638_abnormal_pupillary_reflex0.91005456
70MP0002229_neurodegeneration0.90933022
71MP0000566_synostosis0.89926061
72MP0008872_abnormal_physiological_respon0.87825136
73MP0003634_abnormal_glial_cell0.87517555
74MP0000013_abnormal_adipose_tissue0.86635031
75MP0003632_abnormal_nervous_system0.85225630
76MP0005551_abnormal_eye_electrophysiolog0.84259576
77MP0005253_abnormal_eye_physiology0.83528504
78MP0003861_abnormal_nervous_system0.82185150
79MP0003123_paternal_imprinting0.81271876
80MP0001177_atelectasis0.79852028
81MP0004085_abnormal_heartbeat0.79679653
82MP0002234_abnormal_pharynx_morphology0.79029000
83MP0001963_abnormal_hearing_physiology0.78235346
84MP0005187_abnormal_penis_morphology0.76996320
85MP0003890_abnormal_embryonic-extraembry0.76258219
86MP0003119_abnormal_digestive_system0.75577251
87MP0003137_abnormal_impulse_conducting0.75569619
88MP0005171_absent_coat_pigmentation0.74866189
89MP0001299_abnormal_eye_distance/0.74684266
90MP0000049_abnormal_middle_ear0.73924911
91MP0000604_amyloidosis0.73758853
92MP0005623_abnormal_meninges_morphology0.72742326
93MP0003283_abnormal_digestive_organ0.70717503
94MP0000372_irregular_coat_pigmentation0.69311609
95MP0003938_abnormal_ear_development0.68956388
96MP0005195_abnormal_posterior_eye0.67909239
97MP0008874_decreased_physiological_sensi0.67700903
98MP0005535_abnormal_body_temperature0.67216292
99MP0002837_dystrophic_cardiac_calcinosis0.65674884
100MP0008789_abnormal_olfactory_epithelium0.64437574
101MP0001348_abnormal_lacrimal_gland0.63914547
102MP0004215_abnormal_myocardial_fiber0.63266728
103MP0001943_abnormal_respiration0.61370893
104MP0010769_abnormal_survival0.61147406
105MP0010770_preweaning_lethality0.61058353
106MP0002082_postnatal_lethality0.61058353
107MP0006292_abnormal_olfactory_placode0.61028760
108MP0003136_yellow_coat_color0.60963340
109MP0004233_abnormal_muscle_weight0.60796768
110MP0008995_early_reproductive_senescence0.60555758
111MP0001485_abnormal_pinna_reflex0.59881676
112MP0008961_abnormal_basal_metabolism0.59090523
113MP0002102_abnormal_ear_morphology0.58572627
114MP0010768_mortality/aging0.57467105
115MP0000920_abnormal_myelination0.56657657
116MP0002090_abnormal_vision0.56133740
117MP0003690_abnormal_glial_cell0.55956608
118MP0000026_abnormal_inner_ear0.55081510
119MP0002751_abnormal_autonomic_nervous0.54480730
120MP0006072_abnormal_retinal_apoptosis0.54454710

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.44511592
2Focal motor seizures (HP:0011153)6.19812032
3Focal seizures (HP:0007359)5.19454921
4Visual hallucinations (HP:0002367)5.12923823
5Progressive cerebellar ataxia (HP:0002073)4.42125769
6Atonic seizures (HP:0010819)4.29976172
7Epileptic encephalopathy (HP:0200134)4.27344776
8Febrile seizures (HP:0002373)3.96206477
9Action tremor (HP:0002345)3.92756521
10Limb dystonia (HP:0002451)3.87591538
11Absence seizures (HP:0002121)3.83861525
12Mutism (HP:0002300)3.83003858
13Broad-based gait (HP:0002136)3.68804004
14Supranuclear gaze palsy (HP:0000605)3.64931521
15Ankle clonus (HP:0011448)3.45693163
16Generalized tonic-clonic seizures (HP:0002069)3.40415466
17Dialeptic seizures (HP:0011146)3.38728148
18Poor eye contact (HP:0000817)3.18884104
19Amyotrophic lateral sclerosis (HP:0007354)3.12421277
20Abnormal eating behavior (HP:0100738)3.04744921
21Depression (HP:0000716)3.04685456
22Abnormality of the labia minora (HP:0012880)3.02454861
23Impaired vibration sensation in the lower limbs (HP:0002166)2.97593429
24Abnormality of the corticospinal tract (HP:0002492)2.94473052
25Gaze-evoked nystagmus (HP:0000640)2.94112521
26Excessive salivation (HP:0003781)2.93553204
27Drooling (HP:0002307)2.93553204
28Truncal ataxia (HP:0002078)2.92498186
29Pachygyria (HP:0001302)2.91290067
30Anxiety (HP:0000739)2.90887356
31Dysdiadochokinesis (HP:0002075)2.90536490
32Polyphagia (HP:0002591)2.88003899
33Progressive inability to walk (HP:0002505)2.86222982
34Abnormal social behavior (HP:0012433)2.85217082
35Impaired social interactions (HP:0000735)2.85217082
36Degeneration of the lateral corticospinal tracts (HP:0002314)2.82890037
37Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.82890037
38Torticollis (HP:0000473)2.82555579
39Amblyopia (HP:0000646)2.81301139
40Type II lissencephaly (HP:0007260)2.80214058
41Genetic anticipation (HP:0003743)2.79835307
42Hemiparesis (HP:0001269)2.79561218
43Hyperventilation (HP:0002883)2.79532166
44Abnormality of binocular vision (HP:0011514)2.78860150
45Diplopia (HP:0000651)2.78860150
46Papilledema (HP:0001085)2.73775460
47Urinary bladder sphincter dysfunction (HP:0002839)2.70973257
48Ulnar claw (HP:0001178)2.68474960
49Dysmetria (HP:0001310)2.68330280
50Agitation (HP:0000713)2.65341234
51Urinary urgency (HP:0000012)2.65270700
52Abnormality of the lower motor neuron (HP:0002366)2.65223226
53Focal dystonia (HP:0004373)2.60919883
54Termporal pattern (HP:0011008)2.59919227
55Insidious onset (HP:0003587)2.59919227
56Spastic gait (HP:0002064)2.56728573
57Poor suck (HP:0002033)2.55060459
58Neurofibrillary tangles (HP:0002185)2.54902332
59Cerebral inclusion bodies (HP:0100314)2.51581253
60Cortical dysplasia (HP:0002539)2.50463615
61Spastic tetraplegia (HP:0002510)2.50221824
62Pheochromocytoma (HP:0002666)2.47077089
63Megalencephaly (HP:0001355)2.46852308
64Scanning speech (HP:0002168)2.46521949
65Esotropia (HP:0000565)2.45158692
66Impaired smooth pursuit (HP:0007772)2.42683190
67Craniofacial dystonia (HP:0012179)2.40044964
68Intention tremor (HP:0002080)2.34090005
69Epileptiform EEG discharges (HP:0011182)2.33914294
70Peripheral hypomyelination (HP:0007182)2.33534518
71Medial flaring of the eyebrow (HP:0010747)2.31953843
72EEG with generalized epileptiform discharges (HP:0011198)2.31514532
73Stereotypic behavior (HP:0000733)2.29777126
74Fetal akinesia sequence (HP:0001989)2.29537389
75Akinesia (HP:0002304)2.29236641
76Hemiplegia (HP:0002301)2.25471806
77Hypsarrhythmia (HP:0002521)2.24476297
78Inappropriate behavior (HP:0000719)2.23638532
79Postural instability (HP:0002172)2.20956597
80Abnormality of ocular smooth pursuit (HP:0000617)2.20122221
81Gait imbalance (HP:0002141)2.19383319
82Neuroendocrine neoplasm (HP:0100634)2.19180880
83Nephrogenic diabetes insipidus (HP:0009806)2.17996942
84Abnormal hair whorl (HP:0010721)2.16695883
85Inability to walk (HP:0002540)2.13645443
86Lower limb muscle weakness (HP:0007340)2.13007869
87Morphological abnormality of the pyramidal tract (HP:0002062)2.12828480
88Congenital primary aphakia (HP:0007707)2.12726999
89Bradykinesia (HP:0002067)2.09887830
90Failure to thrive in infancy (HP:0001531)2.07759987
91Absent speech (HP:0001344)2.05892489
92Hypoplasia of the brainstem (HP:0002365)2.05783253
93Aplasia/Hypoplasia of the brainstem (HP:0007362)2.05783253
94Apathy (HP:0000741)2.04433183
95Specific learning disability (HP:0001328)2.03334159
96Neuronal loss in central nervous system (HP:0002529)1.98758153
97Lissencephaly (HP:0001339)1.98087025
98Vaginal atresia (HP:0000148)1.97946857
99Genital tract atresia (HP:0001827)1.97634162
100Hypoventilation (HP:0002791)1.96040943
101Acute necrotizing encephalopathy (HP:0006965)1.94219505
102Status epilepticus (HP:0002133)1.93513103
103Insomnia (HP:0100785)1.92633317
104Atrophy/Degeneration involving motor neurons (HP:0007373)1.91530421
105Dysmetric saccades (HP:0000641)1.91446909
106Abnormality of salivation (HP:0100755)1.90132152
107Pointed chin (HP:0000307)1.88904941
108Retinal dysplasia (HP:0007973)1.88591310
109Ventricular fibrillation (HP:0001663)1.87856665
110Hypoplasia of the corpus callosum (HP:0002079)1.86543492
111Obstructive sleep apnea (HP:0002870)1.86436837
112Incomplete penetrance (HP:0003829)1.83917918
113Sleep apnea (HP:0010535)1.83882013
114Neoplasm of the peripheral nervous system (HP:0100007)1.82993372
115Gait ataxia (HP:0002066)1.82604847
116Hypothermia (HP:0002045)1.82386773
117Clonus (HP:0002169)1.82176084
118Protruding tongue (HP:0010808)1.81939104
119Abnormal mitochondria in muscle tissue (HP:0008316)1.81063235
120Impaired vibratory sensation (HP:0002495)1.81059052
121Psychosis (HP:0000709)1.80200139
122Diminished motivation (HP:0000745)1.80024773
123Polymicrogyria (HP:0002126)1.77706895
124Hip dysplasia (HP:0001385)1.77396251
125Cerebral hypomyelination (HP:0006808)1.77382286
126Narrow nasal bridge (HP:0000446)1.76165300
127Labial hypoplasia (HP:0000066)1.75101920
128Nephronophthisis (HP:0000090)1.74439487
129Split foot (HP:0001839)1.72304218
130Progressive macrocephaly (HP:0004481)1.71461987
131Anterior segment dysgenesis (HP:0007700)1.71003335
132Oligodactyly (hands) (HP:0001180)1.70449664
133Paraplegia (HP:0010550)1.70246360
134Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.69688479
135Muscular hypotonia of the trunk (HP:0008936)1.68656194
136Abnormality of midbrain morphology (HP:0002418)1.67632377

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.49266105
2NTRK33.69488634
3MAP3K93.56379780
4MAP3K43.03974604
5MINK12.88993885
6EPHA42.81842792
7NTRK22.60404993
8MAP2K72.55908683
9DAPK22.20120248
10CASK2.18668930
11PHKG12.04392822
12PHKG22.04392822
13PAK62.01115514
14MAP3K122.00051781
15MAPK131.93499637
16MAP2K41.81812361
17CAMKK11.74095532
18KSR11.62018571
19SIK21.59698335
20MAP4K21.57871314
21NTRK11.56764982
22CDK51.52580282
23PNCK1.50863562
24CAMKK21.48400603
25KSR21.41309563
26TRIM281.39740458
27PLK21.37932151
28TNIK1.37913370
29CDK191.35212749
30LATS21.32879662
31PRKCG1.32152473
32GRK51.28794241
33DAPK11.26283142
34UHMK11.26159626
35ERBB31.22977158
36DYRK21.18284005
37CSNK1G11.17577248
38TYRO31.15376027
39PRPF4B1.12844846
40PRKD31.11484530
41CSNK1G21.06637778
42CDK181.04662338
43CDK151.02535823
44CDK141.00931535
45STK380.97502843
46PAK30.94731352
47CAMK2A0.90499131
48CDK11A0.90183843
49DYRK1A0.89631000
50STK110.87993764
51CAMK2B0.85620468
52ARAF0.84506828
53LIMK10.83231029
54MARK20.81499838
55TESK10.81464168
56SGK4940.79766465
57SGK2230.79766465
58FES0.79578365
59MAP3K20.76743564
60RET0.75229387
61RIPK40.74382520
62TAOK10.72443800
63ADRBK20.72149276
64TLK10.69860943
65PRKCH0.66667154
66CAMK10.66192608
67PRKCZ0.66162850
68ALK0.65679200
69CSNK1G30.65027312
70OXSR10.63365545
71LMTK20.63219972
72DYRK30.62117003
73EPHA30.62058954
74WNK40.61803889
75CAMK1G0.60211818
76RIPK10.58045055
77RPS6KA20.57633275
78GRK70.56411412
79PKN10.56354693
80DYRK1B0.56029748
81PRKCE0.54545052
82INSRR0.54428183
83PRKACA0.54281812
84TAOK30.53806113
85SGK20.52529855
86TESK20.52100296
87PRKG10.51347148
88BCR0.51258430
89SGK10.50755399
90CAMK2G0.50270500
91FYN0.49875199
92CAMK2D0.47810307
93CSNK1D0.47520837
94CSNK1E0.47369359
95SCYL20.46923503
96BMPR1B0.45966511
97MAPK120.45305678
98CSNK1A1L0.45235945
99WNK10.45000834
100WNK30.43953569
101CCNB10.42465849
102RPS6KA30.41882143
103CAMK40.41724140
104MAP3K60.41472259
105ADRBK10.41200726
106PINK10.40780585
107NEK10.40404291
108SGK30.40042078
109FGFR20.39114455
110CDC42BPA0.38289247
111GRK10.38010716
112MAP3K110.38004630
113CSNK1A10.37171016
114RAF10.36623009
115MAPK90.35984185
116SIK30.35743791
117DAPK30.35483307
118PRKAA10.35130469
119ROCK20.34880673
120EPHB20.34742248
121RPS6KA50.34028118
122PDPK10.33234500
123MAPK100.32977920
124ICK0.32966744
125PTK2B0.32715574
126STK390.32315925
127PRKCA0.32245546
128FRK0.32027399
129PDK10.31816976

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.81720582
2Synaptic vesicle cycle_Homo sapiens_hsa047213.32727524
3Olfactory transduction_Homo sapiens_hsa047403.25316020
4GABAergic synapse_Homo sapiens_hsa047272.75888853
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.67900057
6Circadian entrainment_Homo sapiens_hsa047132.65218128
7Glutamatergic synapse_Homo sapiens_hsa047242.56698879
8Morphine addiction_Homo sapiens_hsa050322.49529742
9Long-term potentiation_Homo sapiens_hsa047202.47716295
10Amphetamine addiction_Homo sapiens_hsa050312.30036281
11Dopaminergic synapse_Homo sapiens_hsa047282.27602584
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.12019637
13Salivary secretion_Homo sapiens_hsa049701.97570812
14Cholinergic synapse_Homo sapiens_hsa047251.96957265
15Taste transduction_Homo sapiens_hsa047421.90219673
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.82664828
17Long-term depression_Homo sapiens_hsa047301.81627006
18Insulin secretion_Homo sapiens_hsa049111.79216474
19Gastric acid secretion_Homo sapiens_hsa049711.75979650
20Cocaine addiction_Homo sapiens_hsa050301.75288250
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73712322
22Serotonergic synapse_Homo sapiens_hsa047261.67040352
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63617664
24Renin secretion_Homo sapiens_hsa049241.61257686
25Oxytocin signaling pathway_Homo sapiens_hsa049211.55784165
26Gap junction_Homo sapiens_hsa045401.55242858
27Collecting duct acid secretion_Homo sapiens_hsa049661.49812631
28Axon guidance_Homo sapiens_hsa043601.44089029
29Calcium signaling pathway_Homo sapiens_hsa040201.41970581
30GnRH signaling pathway_Homo sapiens_hsa049121.40364191
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28176013
32Estrogen signaling pathway_Homo sapiens_hsa049151.24406299
33cAMP signaling pathway_Homo sapiens_hsa040241.20177164
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12451529
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11304446
36Cardiac muscle contraction_Homo sapiens_hsa042601.09572478
37Type II diabetes mellitus_Homo sapiens_hsa049301.08168236
38Vibrio cholerae infection_Homo sapiens_hsa051101.06912105
39Glioma_Homo sapiens_hsa052141.04144147
40Melanogenesis_Homo sapiens_hsa049161.03188450
41ErbB signaling pathway_Homo sapiens_hsa040120.99688200
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99451512
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98957534
44Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95970832
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95233847
46Phototransduction_Homo sapiens_hsa047440.93848558
47Oocyte meiosis_Homo sapiens_hsa041140.92146937
48Nitrogen metabolism_Homo sapiens_hsa009100.85016794
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.77969514
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77868179
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.77060375
52Thyroid hormone synthesis_Homo sapiens_hsa049180.76435833
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75888588
54Regulation of autophagy_Homo sapiens_hsa041400.75143873
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75083095
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74815162
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74487688
58Ether lipid metabolism_Homo sapiens_hsa005650.73291172
59Alcoholism_Homo sapiens_hsa050340.73203114
60Steroid biosynthesis_Homo sapiens_hsa001000.71452274
61Pancreatic secretion_Homo sapiens_hsa049720.70930318
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70773354
63Dilated cardiomyopathy_Homo sapiens_hsa054140.70002280
64Protein export_Homo sapiens_hsa030600.69030224
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.68698515
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67887836
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67802931
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67585081
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67104684
70Alzheimers disease_Homo sapiens_hsa050100.66829914
71MAPK signaling pathway_Homo sapiens_hsa040100.66232717
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65547365
73Endometrial cancer_Homo sapiens_hsa052130.64971839
74Dorso-ventral axis formation_Homo sapiens_hsa043200.63784580
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63375284
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63010151
77Choline metabolism in cancer_Homo sapiens_hsa052310.63005633
78Linoleic acid metabolism_Homo sapiens_hsa005910.62819277
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60912452
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60248167
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59831950
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57502727
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56336268
84Ras signaling pathway_Homo sapiens_hsa040140.55864445
85VEGF signaling pathway_Homo sapiens_hsa043700.55421900
86Renal cell carcinoma_Homo sapiens_hsa052110.54423963
87Parkinsons disease_Homo sapiens_hsa050120.53846486
88Oxidative phosphorylation_Homo sapiens_hsa001900.53003550
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.51397541
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51031919
91Glucagon signaling pathway_Homo sapiens_hsa049220.50941373
92Rap1 signaling pathway_Homo sapiens_hsa040150.50858030
93Colorectal cancer_Homo sapiens_hsa052100.50580503
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48886385
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48011408
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47304514
97Wnt signaling pathway_Homo sapiens_hsa043100.46570219
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46131092
99Insulin signaling pathway_Homo sapiens_hsa049100.46037403
100mTOR signaling pathway_Homo sapiens_hsa041500.44924511
101Endocytosis_Homo sapiens_hsa041440.43850720
102Bile secretion_Homo sapiens_hsa049760.42427028
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42367750
104Prion diseases_Homo sapiens_hsa050200.40801667
105Hippo signaling pathway_Homo sapiens_hsa043900.39857552
106Ovarian steroidogenesis_Homo sapiens_hsa049130.39705470
107Non-small cell lung cancer_Homo sapiens_hsa052230.38869270
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37659498
109Basal transcription factors_Homo sapiens_hsa030220.35622287
110Circadian rhythm_Homo sapiens_hsa047100.33872245
111Type I diabetes mellitus_Homo sapiens_hsa049400.33816462
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33269786
113Inositol phosphate metabolism_Homo sapiens_hsa005620.32552689
114Huntingtons disease_Homo sapiens_hsa050160.32437456
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31762756
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31298210
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31119824
118Butanoate metabolism_Homo sapiens_hsa006500.30706090
119Hedgehog signaling pathway_Homo sapiens_hsa043400.29919565
120Phagosome_Homo sapiens_hsa041450.29428179
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.21795625
122AMPK signaling pathway_Homo sapiens_hsa041520.19620632

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