

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit assembly (GO:0000028) | 5.64076790 |
| 2 | viral transcription (GO:0019083) | 5.39357765 |
| 3 | DNA deamination (GO:0045006) | 5.32519103 |
| 4 | translational termination (GO:0006415) | 5.21990209 |
| 5 | ribosomal small subunit biogenesis (GO:0042274) | 5.17668965 |
| 6 | protein complex biogenesis (GO:0070271) | 4.79155491 |
| 7 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.72338543 |
| 8 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.67525000 |
| 9 | cotranslational protein targeting to membrane (GO:0006613) | 4.65147803 |
| 10 | maturation of SSU-rRNA (GO:0030490) | 4.65035274 |
| 11 | translational elongation (GO:0006414) | 4.61288498 |
| 12 | protein targeting to ER (GO:0045047) | 4.59826450 |
| 13 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.55429048 |
| 14 | respiratory electron transport chain (GO:0022904) | 4.49494317 |
| 15 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.44716392 |
| 16 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.44599370 |
| 17 | electron transport chain (GO:0022900) | 4.43191855 |
| 18 | proteasome assembly (GO:0043248) | 4.38407344 |
| 19 | protein localization to endoplasmic reticulum (GO:0070972) | 4.37659796 |
| 20 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.35456894 |
| 21 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.34427260 |
| 22 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.34427260 |
| 23 | NADH dehydrogenase complex assembly (GO:0010257) | 4.34427260 |
| 24 | DNA strand elongation (GO:0022616) | 4.34123793 |
| 25 | translational initiation (GO:0006413) | 4.30139046 |
| 26 | telomere maintenance via recombination (GO:0000722) | 4.27836715 |
| 27 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.23469220 |
| 28 | chaperone-mediated protein transport (GO:0072321) | 4.20959801 |
| 29 | ribosomal large subunit biogenesis (GO:0042273) | 4.19564253 |
| 30 | cellular protein complex disassembly (GO:0043624) | 4.12440517 |
| 31 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.11864542 |
| 32 | viral life cycle (GO:0019058) | 4.11627733 |
| 33 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.98076457 |
| 34 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.94587746 |
| 35 | formation of translation preinitiation complex (GO:0001731) | 3.92939624 |
| 36 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.92518471 |
| 37 | negative regulation of ligase activity (GO:0051352) | 3.91520604 |
| 38 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.91520604 |
| 39 | mitotic recombination (GO:0006312) | 3.89353512 |
| 40 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.77000618 |
| 41 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.76246829 |
| 42 | respiratory chain complex IV assembly (GO:0008535) | 3.74947306 |
| 43 | translation (GO:0006412) | 3.73704646 |
| 44 | protein neddylation (GO:0045116) | 3.72928006 |
| 45 | DNA replication initiation (GO:0006270) | 3.70682322 |
| 46 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.70265830 |
| 47 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.70181982 |
| 48 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.70181982 |
| 49 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.68431109 |
| 50 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.68431109 |
| 51 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.68431109 |
| 52 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.66317470 |
| 53 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.66134373 |
| 54 | cytochrome complex assembly (GO:0017004) | 3.63259408 |
| 55 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.63000205 |
| 56 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.62860159 |
| 57 | base-excision repair, AP site formation (GO:0006285) | 3.61482466 |
| 58 | protein complex disassembly (GO:0043241) | 3.61129865 |
| 59 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.60422356 |
| 60 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.59918446 |
| 61 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.59918446 |
| 62 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.56335391 |
| 63 | DNA replication checkpoint (GO:0000076) | 3.55667035 |
| 64 | telomere maintenance via telomere lengthening (GO:0010833) | 3.50845558 |
| 65 | CENP-A containing nucleosome assembly (GO:0034080) | 3.50434909 |
| 66 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.44203150 |
| 67 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.44203150 |
| 68 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.41985960 |
| 69 | termination of RNA polymerase III transcription (GO:0006386) | 3.41985960 |
| 70 | macromolecular complex disassembly (GO:0032984) | 3.41688379 |
| 71 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.40761819 |
| 72 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.39248112 |
| 73 | rRNA processing (GO:0006364) | 3.37940667 |
| 74 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.36574870 |
| 75 | chromatin remodeling at centromere (GO:0031055) | 3.34843708 |
| 76 | deoxyribonucleotide catabolic process (GO:0009264) | 3.30637523 |
| 77 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.29313276 |
| 78 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.29035442 |
| 79 | regulation of mitochondrial translation (GO:0070129) | 3.28663239 |
| 80 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.26579394 |
| 81 | positive regulation of ligase activity (GO:0051351) | 3.26333929 |
| 82 | rRNA metabolic process (GO:0016072) | 3.26306526 |
| 83 | spliceosomal snRNP assembly (GO:0000387) | 3.26239234 |
| 84 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.24881086 |
| 85 | deoxyribose phosphate catabolic process (GO:0046386) | 3.24019374 |
| 86 | ATP synthesis coupled proton transport (GO:0015986) | 3.21395584 |
| 87 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.21395584 |
| 88 | cullin deneddylation (GO:0010388) | 3.18595765 |
| 89 | purine deoxyribonucleotide catabolic process (GO:0009155) | 3.15579531 |
| 90 | oxidative phosphorylation (GO:0006119) | 3.15256910 |
| 91 | protein deneddylation (GO:0000338) | 3.13335420 |
| 92 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.11756175 |
| 93 | protein-cofactor linkage (GO:0018065) | 3.11616005 |
| 94 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.11163893 |
| 95 | DNA replication-independent nucleosome organization (GO:0034724) | 3.11163893 |
| 96 | ATP biosynthetic process (GO:0006754) | 3.10252017 |
| 97 | viral mRNA export from host cell nucleus (GO:0046784) | 3.09808467 |
| 98 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.09474037 |
| 99 | mRNA catabolic process (GO:0006402) | 3.09472940 |
| 100 | 7-methylguanosine mRNA capping (GO:0006370) | 3.08641294 |
| 101 | preassembly of GPI anchor in ER membrane (GO:0016254) | 3.08390988 |
| 102 | GTP biosynthetic process (GO:0006183) | 3.08060727 |
| 103 | hydrogen ion transmembrane transport (GO:1902600) | 3.05747543 |
| 104 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.04670591 |
| 105 | purine nucleobase biosynthetic process (GO:0009113) | 3.03914268 |
| 106 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.03706615 |
| 107 | cell cycle G1/S phase transition (GO:0044843) | 3.03625119 |
| 108 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.03625119 |
| 109 | cellular component biogenesis (GO:0044085) | 3.03507922 |
| 110 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.02498243 |
| 111 | 7-methylguanosine RNA capping (GO:0009452) | 3.02326076 |
| 112 | RNA capping (GO:0036260) | 3.02326076 |
| 113 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.02213897 |
| 114 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.00681385 |
| 115 | regulation of ligase activity (GO:0051340) | 2.99913602 |
| 116 | nucleobase biosynthetic process (GO:0046112) | 2.98776932 |
| 117 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.98654021 |
| 118 | histone exchange (GO:0043486) | 2.98624116 |
| 119 | positive regulation of cell cycle arrest (GO:0071158) | 2.97362681 |
| 120 | protein targeting to membrane (GO:0006612) | 2.97296335 |
| 121 | RNA catabolic process (GO:0006401) | 2.96525163 |
| 122 | attachment of spindle microtubules to kinetochore (GO:0008608) | 2.95922748 |
| 123 | mannosylation (GO:0097502) | 2.94079132 |
| 124 | ribosome biogenesis (GO:0042254) | 2.93065484 |
| 125 | mitotic metaphase plate congression (GO:0007080) | 2.92779737 |
| 126 | protein localization to kinetochore (GO:0034501) | 2.90956716 |
| 127 | 2-deoxyribonucleotide metabolic process (GO:0009394) | 2.90246549 |
| 128 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.90232894 |
| 129 | rRNA modification (GO:0000154) | 2.88688603 |
| 130 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.86909608 |
| 131 | UTP biosynthetic process (GO:0006228) | 2.85858390 |
| 132 | GPI anchor biosynthetic process (GO:0006506) | 2.85131629 |
| 133 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.84795453 |
| 134 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.84795453 |
| 135 | proton transport (GO:0015992) | 2.84371432 |
| 136 | protein targeting to mitochondrion (GO:0006626) | 2.83728529 |
| 137 | hydrogen transport (GO:0006818) | 2.82543722 |
| 138 | adenosine metabolic process (GO:0046085) | 2.81462496 |
| 139 | deoxyribose phosphate metabolic process (GO:0019692) | 2.81203139 |
| 140 | mast cell activation (GO:0045576) | 2.80958886 |
| 141 | spliceosomal complex assembly (GO:0000245) | 2.80951742 |
| 142 | cytidine deamination (GO:0009972) | 2.79482387 |
| 143 | cytidine metabolic process (GO:0046087) | 2.79482387 |
| 144 | cytidine catabolic process (GO:0006216) | 2.79482387 |
| 145 | aldehyde catabolic process (GO:0046185) | 2.78513535 |
| 146 | regulation of memory T cell differentiation (GO:0043380) | 2.77799416 |
| 147 | purine deoxyribonucleotide metabolic process (GO:0009151) | 2.72769978 |
| 148 | response to interferon-beta (GO:0035456) | 2.72545790 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.00565733 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.05518128 |
| 3 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.80700940 |
| 4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.78931981 |
| 5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.76642392 |
| 6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.67333786 |
| 7 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.50850459 |
| 8 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.31024857 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.28619586 |
| 10 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.07460617 |
| 11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.04406836 |
| 12 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.98967879 |
| 13 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.95020016 |
| 14 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.91148226 |
| 15 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.86252109 |
| 16 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.76891459 |
| 17 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.76375533 |
| 18 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.70310941 |
| 19 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.68090332 |
| 20 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.61328714 |
| 21 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.61321501 |
| 22 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.60176462 |
| 23 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.59372272 |
| 24 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.52677549 |
| 25 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.42510636 |
| 26 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.37373589 |
| 27 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.23169326 |
| 28 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.21074216 |
| 29 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.16974917 |
| 30 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.15465716 |
| 31 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.14350648 |
| 32 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.11184557 |
| 33 | * GABP_19822575_ChIP-Seq_HepG2_Human | 2.02044652 |
| 34 | * SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.97785493 |
| 35 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.96427415 |
| 36 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.90544759 |
| 37 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.85839431 |
| 38 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.83872386 |
| 39 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.80441638 |
| 40 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.80104313 |
| 41 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.78004845 |
| 42 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.77907768 |
| 43 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.77787107 |
| 44 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.70971111 |
| 45 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.67806794 |
| 46 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.67296122 |
| 47 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.63823382 |
| 48 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.60344752 |
| 49 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.59066209 |
| 50 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.56035463 |
| 51 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.55038630 |
| 52 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.54301777 |
| 53 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.52531875 |
| 54 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.42883802 |
| 55 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.42878771 |
| 56 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.40661110 |
| 57 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.40454796 |
| 58 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.37673935 |
| 59 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.35920055 |
| 60 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.35730892 |
| 61 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.34518877 |
| 62 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.28184776 |
| 63 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.27833547 |
| 64 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.27437575 |
| 65 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.26993926 |
| 66 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.26924206 |
| 67 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.23058530 |
| 68 | * ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.22081699 |
| 69 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.20195660 |
| 70 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.18552258 |
| 71 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.18366103 |
| 72 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.18025727 |
| 73 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.14640260 |
| 74 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.14414437 |
| 75 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.13886979 |
| 76 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.13747279 |
| 77 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.12243778 |
| 78 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.12173641 |
| 79 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.11864969 |
| 80 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.08205129 |
| 81 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.07777314 |
| 82 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.06915245 |
| 83 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.06128960 |
| 84 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.06005650 |
| 85 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.05914195 |
| 86 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.04724359 |
| 87 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.02640761 |
| 88 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.02246852 |
| 89 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.01864457 |
| 90 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.00252448 |
| 91 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.00066724 |
| 92 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.99039492 |
| 93 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.98567890 |
| 94 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.98498894 |
| 95 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.96795524 |
| 96 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.96722190 |
| 97 | * MYB_26560356_Chip-Seq_TH2_Human | 0.96626307 |
| 98 | * LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.96412245 |
| 99 | GATA3_26560356_Chip-Seq_TH2_Human | 0.95807630 |
| 100 | AR_20517297_ChIP-Seq_VCAP_Human | 0.94831448 |
| 101 | MYC_22102868_ChIP-Seq_BL_Human | 0.93801529 |
| 102 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.93060328 |
| 103 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.92475672 |
| 104 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.92246243 |
| 105 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.90678203 |
| 106 | * STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.90504881 |
| 107 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.89763063 |
| 108 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.89460323 |
| 109 | * STAT1_20625510_ChIP-Seq_HELA_Human | 0.89376967 |
| 110 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.88805711 |
| 111 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.88364801 |
| 112 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.88282309 |
| 113 | P300_27268052_Chip-Seq_Bcells_Human | 0.87881114 |
| 114 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.86356891 |
| 115 | * RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 0.85967605 |
| 116 | * PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.84281529 |
| 117 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.84052755 |
| 118 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.82509041 |
| 119 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.80454108 |
| 120 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.80268077 |
| 121 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.80074040 |
| 122 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.76351262 |
| 123 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.76108066 |
| 124 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.75109965 |
| 125 | * MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 0.72443536 |
| 126 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.71865924 |
| 127 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 0.71003067 |
| 128 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.70769741 |
| 129 | * TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.66833436 |
| 130 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.66398337 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.27761993 |
| 2 | MP0010094_abnormal_chromosome_stability | 3.84704294 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 3.82065444 |
| 4 | MP0003111_abnormal_nucleus_morphology | 3.50492773 |
| 5 | MP0003077_abnormal_cell_cycle | 3.38031844 |
| 6 | MP0008057_abnormal_DNA_replication | 3.23990069 |
| 7 | MP0008058_abnormal_DNA_repair | 3.11585372 |
| 8 | MP0009379_abnormal_foot_pigmentation | 2.70239267 |
| 9 | MP0008007_abnormal_cellular_replicative | 2.67477812 |
| 10 | MP0008932_abnormal_embryonic_tissue | 2.39085642 |
| 11 | MP0001835_abnormal_antigen_presentation | 2.33754977 |
| 12 | MP0002396_abnormal_hematopoietic_system | 2.30414785 |
| 13 | MP0003763_abnormal_thymus_physiology | 2.16388963 |
| 14 | MP0008875_abnormal_xenobiotic_pharmacok | 2.11282330 |
| 15 | MP0003011_delayed_dark_adaptation | 2.08900790 |
| 16 | MP0005410_abnormal_fertilization | 2.07417793 |
| 17 | MP0003786_premature_aging | 2.05803516 |
| 18 | MP0009333_abnormal_splenocyte_physiolog | 2.03787471 |
| 19 | MP0003195_calcinosis | 1.97378530 |
| 20 | MP0000685_abnormal_immune_system | 1.97186915 |
| 21 | MP0003718_maternal_effect | 1.94483563 |
| 22 | MP0000490_abnormal_crypts_of | 1.83226721 |
| 23 | MP0002837_dystrophic_cardiac_calcinosis | 1.80396749 |
| 24 | MP0005377_hearing/vestibular/ear_phenot | 1.79958212 |
| 25 | MP0003878_abnormal_ear_physiology | 1.79958212 |
| 26 | MP0008877_abnormal_DNA_methylation | 1.79517861 |
| 27 | MP0009764_decreased_sensitivity_to | 1.73859597 |
| 28 | MP0005671_abnormal_response_to | 1.70379997 |
| 29 | MP0008995_early_reproductive_senescence | 1.70079941 |
| 30 | MP0006072_abnormal_retinal_apoptosis | 1.67665621 |
| 31 | MP0002132_abnormal_respiratory_system | 1.60408897 |
| 32 | MP0002876_abnormal_thyroid_physiology | 1.60403624 |
| 33 | MP0002398_abnormal_bone_marrow | 1.55635876 |
| 34 | MP0003186_abnormal_redox_activity | 1.54157407 |
| 35 | MP0001929_abnormal_gametogenesis | 1.54060530 |
| 36 | MP0001853_heart_inflammation | 1.50061861 |
| 37 | MP0002210_abnormal_sex_determination | 1.49954468 |
| 38 | MP0001730_embryonic_growth_arrest | 1.48595017 |
| 39 | MP0003315_abnormal_perineum_morphology | 1.47218965 |
| 40 | MP0000350_abnormal_cell_proliferation | 1.41806604 |
| 41 | MP0009785_altered_susceptibility_to | 1.39294983 |
| 42 | MP0002722_abnormal_immune_system | 1.38296472 |
| 43 | MP0003724_increased_susceptibility_to | 1.38134262 |
| 44 | MP0001800_abnormal_humoral_immune | 1.37316908 |
| 45 | MP0002148_abnormal_hypersensitivity_rea | 1.36728271 |
| 46 | MP0005084_abnormal_gallbladder_morpholo | 1.36701880 |
| 47 | MP0000703_abnormal_thymus_morphology | 1.36174066 |
| 48 | MP0003806_abnormal_nucleotide_metabolis | 1.35746267 |
| 49 | MP0006036_abnormal_mitochondrial_physio | 1.32979193 |
| 50 | MP0000313_abnormal_cell_death | 1.32969400 |
| 51 | MP0003436_decreased_susceptibility_to | 1.32678932 |
| 52 | MP0000689_abnormal_spleen_morphology | 1.32454534 |
| 53 | MP0002429_abnormal_blood_cell | 1.31282631 |
| 54 | MP0002019_abnormal_tumor_incidence | 1.30862327 |
| 55 | MP0002420_abnormal_adaptive_immunity | 1.29916570 |
| 56 | MP0000716_abnormal_immune_system | 1.28948771 |
| 57 | MP0001545_abnormal_hematopoietic_system | 1.28455167 |
| 58 | MP0005397_hematopoietic_system_phenotyp | 1.28455167 |
| 59 | MP0001873_stomach_inflammation | 1.28450701 |
| 60 | MP0001819_abnormal_immune_cell | 1.28215338 |
| 61 | MP0001968_abnormal_touch/_nociception | 1.27335597 |
| 62 | MP0001145_abnormal_male_reproductive | 1.24699410 |
| 63 | MP0002452_abnormal_antigen_presenting | 1.24414565 |
| 64 | MP0001905_abnormal_dopamine_level | 1.24115650 |
| 65 | MP0005379_endocrine/exocrine_gland_phen | 1.23258139 |
| 66 | MP0004808_abnormal_hematopoietic_stem | 1.21627551 |
| 67 | MP0002736_abnormal_nociception_after | 1.21128500 |
| 68 | MP0002160_abnormal_reproductive_system | 1.20504643 |
| 69 | MP0001986_abnormal_taste_sensitivity | 1.20224356 |
| 70 | MP0002405_respiratory_system_inflammati | 1.19302253 |
| 71 | MP0005551_abnormal_eye_electrophysiolog | 1.19301767 |
| 72 | MP0002163_abnormal_gland_morphology | 1.17898001 |
| 73 | MP0002723_abnormal_immune_serum | 1.17688608 |
| 74 | MP0005025_abnormal_response_to | 1.16404228 |
| 75 | MP0008872_abnormal_physiological_respon | 1.16084939 |
| 76 | MP0003567_abnormal_fetal_cardiomyocyte | 1.14418075 |
| 77 | MP0005075_abnormal_melanosome_morpholog | 1.13046744 |
| 78 | MP0005000_abnormal_immune_tolerance | 1.09211852 |
| 79 | MP0008469_abnormal_protein_level | 1.08337210 |
| 80 | MP0000653_abnormal_sex_gland | 1.07476890 |
| 81 | MP0004147_increased_porphyrin_level | 1.05117691 |
| 82 | MP0003698_abnormal_male_reproductive | 1.03448905 |
| 83 | MP0002080_prenatal_lethality | 1.02407671 |
| 84 | MP0002095_abnormal_skin_pigmentation | 1.02065277 |
| 85 | MP0001697_abnormal_embryo_size | 1.01908350 |
| 86 | MP0001529_abnormal_vocalization | 1.01495371 |
| 87 | MP0002638_abnormal_pupillary_reflex | 0.98689191 |
| 88 | MP0005253_abnormal_eye_physiology | 0.97889044 |
| 89 | MP0005636_abnormal_mineral_homeostasis | 0.97836046 |
| 90 | MP0006054_spinal_hemorrhage | 0.97737037 |
| 91 | MP0001919_abnormal_reproductive_system | 0.97319617 |
| 92 | MP0005389_reproductive_system_phenotype | 0.96132455 |
| 93 | MP0009765_abnormal_xenobiotic_induced | 0.96113201 |
| 94 | MP0001501_abnormal_sleep_pattern | 0.95837399 |
| 95 | MP0005319_abnormal_enzyme/_coenzyme | 0.94604062 |
| 96 | MP0005332_abnormal_amino_acid | 0.94225915 |
| 97 | MP0003252_abnormal_bile_duct | 0.92918026 |
| 98 | MP0000358_abnormal_cell_content/ | 0.91223885 |
| 99 | MP0000015_abnormal_ear_pigmentation | 0.88722199 |
| 100 | MP0001764_abnormal_homeostasis | 0.87853645 |
| 101 | MP0003638_abnormal_response/metabolism_ | 0.86595988 |
| 102 | MP0002234_abnormal_pharynx_morphology | 0.85000502 |
| 103 | MP0004043_abnormal_pH_regulation | 0.84814404 |
| 104 | MP0005360_urolithiasis | 0.84752755 |
| 105 | MP0005387_immune_system_phenotype | 0.84677687 |
| 106 | MP0001790_abnormal_immune_system | 0.84677687 |
| 107 | MP0005408_hypopigmentation | 0.83940078 |
| 108 | MP0008789_abnormal_olfactory_epithelium | 0.83602645 |
| 109 | MP0008260_abnormal_autophagy | 0.83453210 |
| 110 | MP0001533_abnormal_skeleton_physiology | 0.83222188 |
| 111 | MP0003136_yellow_coat_color | 0.83023840 |
| 112 | MP0004142_abnormal_muscle_tone | 0.82837474 |
| 113 | MP0009697_abnormal_copulation | 0.82075752 |
| 114 | MP0001672_abnormal_embryogenesis/_devel | 0.81448826 |
| 115 | MP0005380_embryogenesis_phenotype | 0.81448826 |
| 116 | MP0003866_abnormal_defecation | 0.80763916 |
| 117 | MP0000372_irregular_coat_pigmentation | 0.80729334 |
| 118 | MP0002938_white_spotting | 0.79620783 |
| 119 | MP0000858_altered_metastatic_potential | 0.79313776 |
| 120 | MP0002102_abnormal_ear_morphology | 0.78649429 |
| 121 | MP0005646_abnormal_pituitary_gland | 0.78187514 |
| 122 | MP0006292_abnormal_olfactory_placode | 0.77763518 |
| 123 | MP0009763_increased_sensitivity_to | 0.77079608 |
| 124 | MP0005645_abnormal_hypothalamus_physiol | 0.77058064 |
| 125 | MP0005464_abnormal_platelet_physiology | 0.76908645 |
| 126 | MP0006035_abnormal_mitochondrial_morpho | 0.76598757 |
| 127 | MP0002277_abnormal_respiratory_mucosa | 0.75695807 |
| 128 | MP0004145_abnormal_muscle_electrophysio | 0.75524377 |
| 129 | MP0003984_embryonic_growth_retardation | 0.74722523 |
| 130 | MP0001119_abnormal_female_reproductive | 0.74472577 |
| 131 | MP0010155_abnormal_intestine_physiology | 0.73646821 |
| 132 | MP0003221_abnormal_cardiomyocyte_apopto | 0.71413445 |
| 133 | MP0002088_abnormal_embryonic_growth/wei | 0.70988165 |
| 134 | MP0002085_abnormal_embryonic_tissue | 0.70666902 |
| 135 | MP0002419_abnormal_innate_immunity | 0.69895161 |
| 136 | MP0003656_abnormal_erythrocyte_physiolo | 0.68522662 |
| 137 | MP0005174_abnormal_tail_pigmentation | 0.68166125 |
| 138 | MP0001727_abnormal_embryo_implantation | 0.66212687 |
| 139 | MP0001845_abnormal_inflammatory_respons | 0.66099223 |
| 140 | MP0002161_abnormal_fertility/fecundity | 0.65697650 |
| 141 | MP0003646_muscle_fatigue | 0.63882039 |
| 142 | MP0001348_abnormal_lacrimal_gland | 0.62371081 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 5.59663868 |
| 2 | Abnormal number of erythroid precursors (HP:0012131) | 5.32170399 |
| 3 | Reticulocytopenia (HP:0001896) | 4.93538187 |
| 4 | Macrocytic anemia (HP:0001972) | 3.74417510 |
| 5 | Hepatocellular necrosis (HP:0001404) | 3.51392143 |
| 6 | Pallor (HP:0000980) | 3.48221776 |
| 7 | Acute necrotizing encephalopathy (HP:0006965) | 3.47919413 |
| 8 | Aplastic anemia (HP:0001915) | 3.45205443 |
| 9 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.44848914 |
| 10 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.44848914 |
| 11 | Mitochondrial inheritance (HP:0001427) | 3.41443719 |
| 12 | Birth length less than 3rd percentile (HP:0003561) | 3.38575845 |
| 13 | Cerebral edema (HP:0002181) | 3.32086091 |
| 14 | Hepatic necrosis (HP:0002605) | 3.27812947 |
| 15 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.19822688 |
| 16 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.09976585 |
| 17 | Severe combined immunodeficiency (HP:0004430) | 3.09115704 |
| 18 | Increased CSF lactate (HP:0002490) | 3.04128161 |
| 19 | Increased hepatocellular lipid droplets (HP:0006565) | 3.00623414 |
| 20 | 3-Methylglutaconic aciduria (HP:0003535) | 2.98463743 |
| 21 | Abnormality of the anterior horn cell (HP:0006802) | 2.97771708 |
| 22 | Degeneration of anterior horn cells (HP:0002398) | 2.97771708 |
| 23 | Oral leukoplakia (HP:0002745) | 2.89208617 |
| 24 | Breast hypoplasia (HP:0003187) | 2.88560065 |
| 25 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.79271082 |
| 26 | 11 pairs of ribs (HP:0000878) | 2.78264629 |
| 27 | Rough bone trabeculation (HP:0100670) | 2.75890560 |
| 28 | Lipid accumulation in hepatocytes (HP:0006561) | 2.70014411 |
| 29 | Type I transferrin isoform profile (HP:0003642) | 2.69397671 |
| 30 | Exertional dyspnea (HP:0002875) | 2.68203271 |
| 31 | Increased serum lactate (HP:0002151) | 2.67531861 |
| 32 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.66638708 |
| 33 | IgM deficiency (HP:0002850) | 2.59806638 |
| 34 | Progressive macrocephaly (HP:0004481) | 2.58701625 |
| 35 | Cerebral hypomyelination (HP:0006808) | 2.58019005 |
| 36 | Carpal bone hypoplasia (HP:0001498) | 2.57389788 |
| 37 | Acute encephalopathy (HP:0006846) | 2.57111763 |
| 38 | Optic disc pallor (HP:0000543) | 2.56318561 |
| 39 | Multiple enchondromatosis (HP:0005701) | 2.50526027 |
| 40 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.49793836 |
| 41 | Combined immunodeficiency (HP:0005387) | 2.48207887 |
| 42 | Microretrognathia (HP:0000308) | 2.42598542 |
| 43 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.42351160 |
| 44 | Congenital stationary night blindness (HP:0007642) | 2.41835946 |
| 45 | Dicarboxylic aciduria (HP:0003215) | 2.40596189 |
| 46 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.40596189 |
| 47 | Thrombocytosis (HP:0001894) | 2.36934756 |
| 48 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.34924200 |
| 49 | Pancreatic cysts (HP:0001737) | 2.33771323 |
| 50 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.33360850 |
| 51 | Poor head control (HP:0002421) | 2.32881223 |
| 52 | Renal cortical cysts (HP:0000803) | 2.32611755 |
| 53 | Abnormality of T cells (HP:0002843) | 2.31247566 |
| 54 | Generalized aminoaciduria (HP:0002909) | 2.30504622 |
| 55 | Pancreatic fibrosis (HP:0100732) | 2.30462780 |
| 56 | Type 2 muscle fiber atrophy (HP:0003554) | 2.28945265 |
| 57 | Patellar aplasia (HP:0006443) | 2.27623012 |
| 58 | Muscle fiber atrophy (HP:0100295) | 2.26868507 |
| 59 | Methylmalonic aciduria (HP:0012120) | 2.25360083 |
| 60 | Lethargy (HP:0001254) | 2.23474393 |
| 61 | Recurrent bronchitis (HP:0002837) | 2.23301904 |
| 62 | Abnormality of the preputium (HP:0100587) | 2.22525165 |
| 63 | Abnormality of T cell physiology (HP:0011840) | 2.20901223 |
| 64 | Pancytopenia (HP:0001876) | 2.20854309 |
| 65 | Exercise intolerance (HP:0003546) | 2.20740220 |
| 66 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.20293765 |
| 67 | Molar tooth sign on MRI (HP:0002419) | 2.19726535 |
| 68 | Abnormality of midbrain morphology (HP:0002418) | 2.19726535 |
| 69 | Agammaglobulinemia (HP:0004432) | 2.17070036 |
| 70 | Methylmalonic acidemia (HP:0002912) | 2.15995603 |
| 71 | Abnormality of the ileum (HP:0001549) | 2.14527533 |
| 72 | Meckel diverticulum (HP:0002245) | 2.13272151 |
| 73 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.13158524 |
| 74 | Increased serum pyruvate (HP:0003542) | 2.13118830 |
| 75 | Abnormality of glycolysis (HP:0004366) | 2.13118830 |
| 76 | Increased intramyocellular lipid droplets (HP:0012240) | 2.12589634 |
| 77 | Renal Fanconi syndrome (HP:0001994) | 2.12426394 |
| 78 | Respiratory difficulties (HP:0002880) | 2.12084777 |
| 79 | Abnormal trabecular bone morphology (HP:0100671) | 2.11864255 |
| 80 | Trismus (HP:0000211) | 2.11722680 |
| 81 | Progressive microcephaly (HP:0000253) | 2.10852756 |
| 82 | Respiratory failure (HP:0002878) | 2.08533900 |
| 83 | Petechiae (HP:0000967) | 2.07829738 |
| 84 | Lactic acidosis (HP:0003128) | 2.06066018 |
| 85 | Abnormal lung lobation (HP:0002101) | 2.05179285 |
| 86 | Nephronophthisis (HP:0000090) | 2.04132463 |
| 87 | Abnormal spermatogenesis (HP:0008669) | 2.03859221 |
| 88 | Leukodystrophy (HP:0002415) | 2.03693641 |
| 89 | Cleft eyelid (HP:0000625) | 2.03101192 |
| 90 | True hermaphroditism (HP:0010459) | 2.02773742 |
| 91 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.02676735 |
| 92 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.02676735 |
| 93 | Congenital, generalized hypertrichosis (HP:0004540) | 2.01689782 |
| 94 | Colon cancer (HP:0003003) | 2.01391947 |
| 95 | Secondary amenorrhea (HP:0000869) | 1.99352442 |
| 96 | Absent thumb (HP:0009777) | 1.98988224 |
| 97 | Delayed CNS myelination (HP:0002188) | 1.98659912 |
| 98 | Selective tooth agenesis (HP:0001592) | 1.98113392 |
| 99 | Tongue fasciculations (HP:0001308) | 1.97748709 |
| 100 | Abnormality of renal resorption (HP:0011038) | 1.97250301 |
| 101 | Chronic otitis media (HP:0000389) | 1.97248579 |
| 102 | Myositis (HP:0100614) | 1.96305564 |
| 103 | Bone marrow hypocellularity (HP:0005528) | 1.95645548 |
| 104 | Abolished electroretinogram (ERG) (HP:0000550) | 1.95510746 |
| 105 | CNS demyelination (HP:0007305) | 1.94527552 |
| 106 | Depressed nasal ridge (HP:0000457) | 1.93334995 |
| 107 | Emotional lability (HP:0000712) | 1.93018285 |
| 108 | Bronchitis (HP:0012387) | 1.92323276 |
| 109 | Nasal polyposis (HP:0100582) | 1.92198864 |
| 110 | T lymphocytopenia (HP:0005403) | 1.91328603 |
| 111 | Sparse eyelashes (HP:0000653) | 1.91289167 |
| 112 | Abnormality of urine glucose concentration (HP:0011016) | 1.91269743 |
| 113 | Glycosuria (HP:0003076) | 1.91269743 |
| 114 | Brittle hair (HP:0002299) | 1.90957834 |
| 115 | Neutropenia (HP:0001875) | 1.90916381 |
| 116 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.89951422 |
| 117 | Thyroiditis (HP:0100646) | 1.89569834 |
| 118 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.89542713 |
| 119 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.89542713 |
| 120 | Abnormal protein glycosylation (HP:0012346) | 1.89542713 |
| 121 | Abnormal glycosylation (HP:0012345) | 1.89542713 |
| 122 | Absent epiphyses (HP:0010577) | 1.88311168 |
| 123 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.88311168 |
| 124 | Chronic mucocutaneous candidiasis (HP:0002728) | 1.88271541 |
| 125 | Recurrent cutaneous fungal infections (HP:0011370) | 1.88271541 |
| 126 | IgG deficiency (HP:0004315) | 1.87922508 |
| 127 | Hyperglycinemia (HP:0002154) | 1.87783469 |
| 128 | Triphalangeal thumb (HP:0001199) | 1.87519971 |
| 129 | Premature graying of hair (HP:0002216) | 1.87204185 |
| 130 | Myelodysplasia (HP:0002863) | 1.85246979 |
| 131 | Panhypogammaglobulinemia (HP:0003139) | 1.84992159 |
| 132 | Duodenal stenosis (HP:0100867) | 1.84096213 |
| 133 | Small intestinal stenosis (HP:0012848) | 1.84096213 |
| 134 | Increased muscle lipid content (HP:0009058) | 1.83964110 |
| 135 | Chromsome breakage (HP:0040012) | 1.83482165 |
| 136 | Reduced antithrombin III activity (HP:0001976) | 1.82904240 |
| 137 | Rhinitis (HP:0012384) | 1.81996299 |
| 138 | Anhidrosis (HP:0000970) | 1.80901616 |
| 139 | B lymphocytopenia (HP:0010976) | 1.79003502 |
| 140 | Abnormality of eosinophils (HP:0001879) | 1.77888738 |
| 141 | Encephalitis (HP:0002383) | 1.76749808 |
| 142 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.76702707 |
| 143 | Cerebral palsy (HP:0100021) | 1.76255016 |
| 144 | Abnormality of T cell number (HP:0011839) | 1.74268000 |
| 145 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 1.73175817 |
| 146 | Abnormality of the renal cortex (HP:0011035) | 1.69978653 |
| 147 | Nausea (HP:0002018) | 1.69414441 |
| 148 | Abnormality of fatty-acid metabolism (HP:0004359) | 1.69086701 |
| 149 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.67338844 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 5.28103904 |
| 2 | VRK2 | 5.22643130 |
| 3 | WEE1 | 4.19037808 |
| 4 | NME2 | 3.65183206 |
| 5 | STK16 | 3.52028915 |
| 6 | MAP4K2 | 2.88613137 |
| 7 | NUAK1 | 2.66220674 |
| 8 | EIF2AK1 | 2.61544765 |
| 9 | ACVR1B | 2.53726849 |
| 10 | VRK1 | 2.35780213 |
| 11 | SRPK1 | 2.34985549 |
| 12 | EIF2AK3 | 2.22338246 |
| 13 | BRSK2 | 2.21773293 |
| 14 | PIM2 | 2.12316041 |
| 15 | CDC7 | 2.03835374 |
| 16 | TESK2 | 1.91944759 |
| 17 | MUSK | 1.88943847 |
| 18 | CCNB1 | 1.84015833 |
| 19 | ADRBK2 | 1.83644353 |
| 20 | DYRK3 | 1.82798465 |
| 21 | PLK4 | 1.79851116 |
| 22 | KDR | 1.79516177 |
| 23 | TAOK3 | 1.72773995 |
| 24 | GRK6 | 1.64693854 |
| 25 | TLK1 | 1.63880315 |
| 26 | NEK2 | 1.57938441 |
| 27 | TESK1 | 1.56778489 |
| 28 | TSSK6 | 1.53850312 |
| 29 | MAP4K1 | 1.44839257 |
| 30 | PASK | 1.44649209 |
| 31 | PLK1 | 1.40949750 |
| 32 | AURKB | 1.31172670 |
| 33 | GRK1 | 1.29259309 |
| 34 | BRSK1 | 1.26134781 |
| 35 | MST4 | 1.22175536 |
| 36 | TTK | 1.21029850 |
| 37 | TEC | 1.20060753 |
| 38 | NLK | 1.18658528 |
| 39 | MKNK1 | 1.18562653 |
| 40 | IRAK4 | 1.18433831 |
| 41 | TGFBR1 | 1.15294433 |
| 42 | RPS6KA4 | 1.14906948 |
| 43 | RPS6KB2 | 1.13923713 |
| 44 | NME1 | 1.13462564 |
| 45 | AURKA | 1.11215924 |
| 46 | DYRK2 | 1.07089191 |
| 47 | BRAF | 1.04679351 |
| 48 | ZAP70 | 1.03600463 |
| 49 | MAPKAPK3 | 0.98352613 |
| 50 | CDK7 | 0.97242375 |
| 51 | BTK | 0.96374772 |
| 52 | BLK | 0.96186365 |
| 53 | PDK3 | 0.94871590 |
| 54 | PDK4 | 0.94871590 |
| 55 | ZAK | 0.93927194 |
| 56 | PLK3 | 0.91615900 |
| 57 | ARAF | 0.91333732 |
| 58 | CHEK2 | 0.90784260 |
| 59 | ATR | 0.89839988 |
| 60 | BMPR1B | 0.87655382 |
| 61 | CSNK1G3 | 0.86444852 |
| 62 | MAP3K14 | 0.85344991 |
| 63 | DAPK1 | 0.82179064 |
| 64 | PRKCQ | 0.81118159 |
| 65 | EPHA2 | 0.77176221 |
| 66 | LRRK2 | 0.76919031 |
| 67 | CDK8 | 0.76347991 |
| 68 | STK10 | 0.75849383 |
| 69 | PIM1 | 0.75717071 |
| 70 | EIF2AK2 | 0.75550893 |
| 71 | LIMK1 | 0.73653890 |
| 72 | RPS6KA5 | 0.73607338 |
| 73 | NEK1 | 0.73169233 |
| 74 | PAK1 | 0.72094757 |
| 75 | ILK | 0.71943216 |
| 76 | MYLK | 0.71615813 |
| 77 | KIT | 0.70531352 |
| 78 | CSNK2A1 | 0.70254108 |
| 79 | MATK | 0.68993932 |
| 80 | CLK1 | 0.68736148 |
| 81 | FES | 0.67656172 |
| 82 | PBK | 0.67440774 |
| 83 | STK4 | 0.65454694 |
| 84 | TBK1 | 0.64867773 |
| 85 | PAK4 | 0.64693737 |
| 86 | MAP3K8 | 0.63757749 |
| 87 | IKBKB | 0.63516497 |
| 88 | CSNK1G2 | 0.61164051 |
| 89 | PRKCI | 0.60593449 |
| 90 | CSNK2A2 | 0.59477212 |
| 91 | TXK | 0.59128228 |
| 92 | GRK7 | 0.58974623 |
| 93 | PINK1 | 0.58880283 |
| 94 | SYK | 0.56734904 |
| 95 | IRAK3 | 0.56149392 |
| 96 | PHKG1 | 0.55339140 |
| 97 | PHKG2 | 0.55339140 |
| 98 | DAPK3 | 0.55036199 |
| 99 | TNK2 | 0.54311111 |
| 100 | MARK3 | 0.52396549 |
| 101 | CSF1R | 0.51975301 |
| 102 | TYK2 | 0.51957239 |
| 103 | MAP3K11 | 0.51534756 |
| 104 | BCKDK | 0.51502125 |
| 105 | CHEK1 | 0.51258034 |
| 106 | SCYL2 | 0.50843947 |
| 107 | LCK | 0.50836652 |
| 108 | MKNK2 | 0.49748485 |
| 109 | ERN1 | 0.49300345 |
| 110 | WNK3 | 0.49038483 |
| 111 | MAPKAPK5 | 0.48370132 |
| 112 | BMPR2 | 0.47698239 |
| 113 | LYN | 0.45474419 |
| 114 | CSNK1G1 | 0.44524983 |
| 115 | IKBKE | 0.44353021 |
| 116 | CDK4 | 0.43964692 |
| 117 | ADRBK1 | 0.43748687 |
| 118 | CSNK1A1L | 0.43675059 |
| 119 | PDK2 | 0.42954813 |
| 120 | MAP3K12 | 0.42066623 |
| 121 | GRK5 | 0.40983415 |
| 122 | DYRK1B | 0.40707583 |
| 123 | JAK3 | 0.40176549 |
| 124 | MAP2K3 | 0.39468444 |
| 125 | OXSR1 | 0.39421915 |
| 126 | WNK4 | 0.37284404 |
| 127 | MAPK13 | 0.36793762 |
| 128 | IGF1R | 0.36511671 |
| 129 | ABL2 | 0.36232367 |
| 130 | MAPK15 | 0.35987652 |
| 131 | YES1 | 0.35915973 |
| 132 | MELK | 0.35261000 |
| 133 | FLT3 | 0.35175986 |
| 134 | TAF1 | 0.35150349 |
| 135 | CDK19 | 0.33306952 |
| 136 | MAP2K2 | 0.32354764 |
| 137 | ITK | 0.31898004 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 4.89477709 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 4.64621464 |
| 3 | DNA replication_Homo sapiens_hsa03030 | 4.55862984 |
| 4 | Mismatch repair_Homo sapiens_hsa03430 | 3.73258352 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 3.34462497 |
| 6 | Homologous recombination_Homo sapiens_hsa03440 | 3.02927542 |
| 7 | Base excision repair_Homo sapiens_hsa03410 | 2.85624500 |
| 8 | Spliceosome_Homo sapiens_hsa03040 | 2.85435548 |
| 9 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.67778732 |
| 10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.64471283 |
| 11 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.58785099 |
| 12 | RNA transport_Homo sapiens_hsa03013 | 2.26359929 |
| 13 | Parkinsons disease_Homo sapiens_hsa05012 | 2.10388819 |
| 14 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.09251132 |
| 15 | Protein export_Homo sapiens_hsa03060 | 2.07067530 |
| 16 | Cell cycle_Homo sapiens_hsa04110 | 1.97248213 |
| 17 | Basal transcription factors_Homo sapiens_hsa03022 | 1.85184378 |
| 18 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.79761506 |
| 19 | Huntingtons disease_Homo sapiens_hsa05016 | 1.78030213 |
| 20 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.75247281 |
| 21 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.65880180 |
| 22 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.64511901 |
| 23 | RNA degradation_Homo sapiens_hsa03018 | 1.62052112 |
| 24 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.57274049 |
| 25 | Purine metabolism_Homo sapiens_hsa00230 | 1.49235585 |
| 26 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.47756061 |
| 27 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.41937140 |
| 28 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.37588500 |
| 29 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.30119022 |
| 30 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.28199455 |
| 31 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.22878888 |
| 32 | Alzheimers disease_Homo sapiens_hsa05010 | 1.21968097 |
| 33 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.20591015 |
| 34 | Peroxisome_Homo sapiens_hsa04146 | 1.18895661 |
| 35 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.17419698 |
| 36 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.17051811 |
| 37 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.16254835 |
| 38 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.12552771 |
| 39 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.06120809 |
| 40 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.03794715 |
| 41 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.03785697 |
| 42 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.02984999 |
| 43 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.96659072 |
| 44 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.91106858 |
| 45 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.90988181 |
| 46 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.88618764 |
| 47 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.88148347 |
| 48 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.85088620 |
| 49 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.81980568 |
| 50 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.81099965 |
| 51 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.77523138 |
| 52 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.77188809 |
| 53 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.76999980 |
| 54 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.72470259 |
| 55 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.71907904 |
| 56 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.71209075 |
| 57 | Phototransduction_Homo sapiens_hsa04744 | 0.71174458 |
| 58 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.69165148 |
| 59 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.68138324 |
| 60 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.68093665 |
| 61 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.67541154 |
| 62 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.66357374 |
| 63 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.65996607 |
| 64 | Sulfur relay system_Homo sapiens_hsa04122 | 0.65454049 |
| 65 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.65102617 |
| 66 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.65062555 |
| 67 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.62644527 |
| 68 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.59989328 |
| 69 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.59890434 |
| 70 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.59027938 |
| 71 | Allograft rejection_Homo sapiens_hsa05330 | 0.57881251 |
| 72 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.54738105 |
| 73 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.54465022 |
| 74 | Asthma_Homo sapiens_hsa05310 | 0.54383753 |
| 75 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.54112283 |
| 76 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.53979128 |
| 77 | Metabolic pathways_Homo sapiens_hsa01100 | 0.51165796 |
| 78 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.50985755 |
| 79 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.50068416 |
| 80 | Legionellosis_Homo sapiens_hsa05134 | 0.49751863 |
| 81 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.49650257 |
| 82 | Shigellosis_Homo sapiens_hsa05131 | 0.49270710 |
| 83 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.49037783 |
| 84 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.48949781 |
| 85 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.48239339 |
| 86 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.47771053 |
| 87 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.46711457 |
| 88 | Measles_Homo sapiens_hsa05162 | 0.45035264 |
| 89 | HTLV-I infection_Homo sapiens_hsa05166 | 0.44468012 |
| 90 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.44209559 |
| 91 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.43591381 |
| 92 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.43584032 |
| 93 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.38805744 |
| 94 | Retinol metabolism_Homo sapiens_hsa00830 | 0.38725949 |
| 95 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.37922431 |
| 96 | Carbon metabolism_Homo sapiens_hsa01200 | 0.37131368 |
| 97 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.36990188 |
| 98 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.36264923 |
| 99 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.36238122 |
| 100 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.35952125 |
| 101 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.34947334 |
| 102 | Apoptosis_Homo sapiens_hsa04210 | 0.34835553 |
| 103 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.34762586 |
| 104 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.34499383 |
| 105 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.33956992 |
| 106 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.30728289 |
| 107 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.30117878 |
| 108 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.28822139 |
| 109 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.27757679 |
| 110 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.27669348 |
| 111 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.25086956 |
| 112 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.24883751 |
| 113 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.23859612 |
| 114 | Viral myocarditis_Homo sapiens_hsa05416 | 0.23746967 |
| 115 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.23637151 |
| 116 | Alcoholism_Homo sapiens_hsa05034 | 0.23407345 |
| 117 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.23263234 |
| 118 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.22730270 |
| 119 | Thyroid cancer_Homo sapiens_hsa05216 | 0.22496757 |
| 120 | Other glycan degradation_Homo sapiens_hsa00511 | 0.20358197 |
| 121 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.20116206 |
| 122 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.19588943 |
| 123 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.18384003 |
| 124 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.18381619 |
| 125 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.17949252 |
| 126 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.17128922 |
| 127 | Leishmaniasis_Homo sapiens_hsa05140 | 0.16881272 |
| 128 | Hepatitis B_Homo sapiens_hsa05161 | 0.16377927 |
| 129 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.15745771 |
| 130 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.13661882 |
| 131 | Galactose metabolism_Homo sapiens_hsa00052 | 0.13133742 |
| 132 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.12961851 |
| 133 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.12657118 |
| 134 | Influenza A_Homo sapiens_hsa05164 | 0.11099139 |

