NSMCE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of E3 small ubiquitin-related modifier (SUMO) ligases that mediates the attachment of a SUMO protein to proteins involved in nuclear transport, transcription, chromosome segregation and DNA repair. The encoded protein is part of the structural maintenance of chromosomes (SMC) 5/6 complex which plays a key role genome maintenance, facilitating chromosome segregation and suppressing mitotic recombination. A knockout of the orthologous mouse gene is lethal prior to embryonic day 10.5. Naturally occurring mutations in this gene, that abolish the SUMO ligase activity, are associated with primordial dwarfism and extreme insulin resistance. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein prenylation (GO:0018342)7.59833910
2prenylation (GO:0097354)7.59833910
3L-fucose catabolic process (GO:0042355)5.22326754
4fucose catabolic process (GO:0019317)5.22326754
5L-fucose metabolic process (GO:0042354)5.22326754
6negative regulation of Ras GTPase activity (GO:0034261)5.07515677
7CENP-A containing nucleosome assembly (GO:0034080)4.93857768
8eosinophil chemotaxis (GO:0048245)4.92796070
9mitotic metaphase plate congression (GO:0007080)4.82003038
10kinetochore organization (GO:0051383)4.80042573
11kinetochore assembly (GO:0051382)4.72936598
12chromatin remodeling at centromere (GO:0031055)4.67892204
13attachment of spindle microtubules to kinetochore (GO:0008608)4.55235581
14eosinophil migration (GO:0072677)4.43635127
15proteasome assembly (GO:0043248)4.30736206
16DNA replication checkpoint (GO:0000076)4.25319967
17metaphase plate congression (GO:0051310)4.18842574
18vesicle fusion (GO:0006906)4.16773483
19telomere maintenance via semi-conservative replication (GO:0032201)4.11178915
20DNA replication-independent nucleosome assembly (GO:0006336)4.09559088
21DNA replication-independent nucleosome organization (GO:0034724)4.09559088
22mitochondrial RNA metabolic process (GO:0000959)4.06369221
23negative regulation of T cell receptor signaling pathway (GO:0050860)4.04709882
24establishment of chromosome localization (GO:0051303)4.04538843
25DNA strand elongation involved in DNA replication (GO:0006271)4.02139929
26maturation of 5.8S rRNA (GO:0000460)3.93634712
27anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.91668846
28histone exchange (GO:0043486)3.91099437
29negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.89771183
30DNA strand elongation (GO:0022616)3.86977353
31* telomere maintenance via recombination (GO:0000722)3.86921737
32regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.84971234
33positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.82355993
34regulation of mononuclear cell migration (GO:0071675)3.82187105
35protein localization to kinetochore (GO:0034501)3.80759489
36branch elongation of an epithelium (GO:0060602)3.80016826
37rRNA modification (GO:0000154)3.79765175
387-methylguanosine RNA capping (GO:0009452)3.79653969
39RNA capping (GO:0036260)3.79653969
407-methylguanosine mRNA capping (GO:0006370)3.79299184
41preassembly of GPI anchor in ER membrane (GO:0016254)3.74090424
42organelle membrane fusion (GO:0090174)3.65000325
43* mitotic recombination (GO:0006312)3.64815474
44cullin deneddylation (GO:0010388)3.64525210
45protein deneddylation (GO:0000338)3.64470541
46DNA replication initiation (GO:0006270)3.56296075
47mitotic sister chromatid segregation (GO:0000070)3.55443095
48autophagic vacuole fusion (GO:0000046)3.55338039
49negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.54543917
50negative regulation of ligase activity (GO:0051352)3.54543917
51protein-cofactor linkage (GO:0018065)3.50268524
52transcription-coupled nucleotide-excision repair (GO:0006283)3.47251767
53telomere maintenance via telomere lengthening (GO:0010833)3.45191937
54establishment of protein localization to mitochondrial membrane (GO:0090151)3.44854046
55purine nucleobase biosynthetic process (GO:0009113)3.41247011
56nucleotide-excision repair, DNA gap filling (GO:0006297)3.39424057
57mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.39315453
58protein localization to chromosome, centromeric region (GO:0071459)3.38009871
59nucleobase biosynthetic process (GO:0046112)3.36587628
60DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.36292229
61positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.36234956
62meiotic chromosome segregation (GO:0045132)3.35925622
63signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.32243833
64signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.32243833
65signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.32243833
66regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.31310418
67intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.31091316
68signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.31091316
69spindle checkpoint (GO:0031577)3.29925877
70maturation of SSU-rRNA (GO:0030490)3.29723648
71regulation of spindle organization (GO:0090224)3.29151122
72termination of RNA polymerase III transcription (GO:0006386)3.26616653
73transcription elongation from RNA polymerase III promoter (GO:0006385)3.26616653
74intracellular protein transmembrane import (GO:0044743)3.26373271
75rRNA methylation (GO:0031167)3.24807818
76spliceosomal snRNP assembly (GO:0000387)3.24619652
77signal transduction involved in DNA damage checkpoint (GO:0072422)3.24042290
78signal transduction involved in DNA integrity checkpoint (GO:0072401)3.24042290
79negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.23322587
80water-soluble vitamin biosynthetic process (GO:0042364)3.23031947
81DNA integration (GO:0015074)3.22744883
82signal transduction involved in cell cycle checkpoint (GO:0072395)3.22665297
83negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.22356694
84positive regulation of ligase activity (GO:0051351)3.21987595
85regulation of double-strand break repair via homologous recombination (GO:0010569)3.20972789
86formation of translation preinitiation complex (GO:0001731)3.20691924
87protein neddylation (GO:0045116)3.19869749
88regulation of cellular amino acid metabolic process (GO:0006521)3.18451404
89mitotic chromosome condensation (GO:0007076)3.18230667
90microtubule depolymerization (GO:0007019)3.18041054
91metallo-sulfur cluster assembly (GO:0031163)3.17990207
92iron-sulfur cluster assembly (GO:0016226)3.17990207
93protein complex biogenesis (GO:0070271)3.14917904
94chaperone-mediated protein transport (GO:0072321)3.14030182
95antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.13707651
96positive regulation of calcium ion import (GO:0090280)3.13529019
97negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.12230020
98chromosome segregation (GO:0007059)3.12158246
99ribosomal small subunit assembly (GO:0000028)3.11895214
100cell cycle G1/S phase transition (GO:0044843)3.11263024
101G1/S transition of mitotic cell cycle (GO:0000082)3.11263024
102mitochondrial respiratory chain complex assembly (GO:0033108)3.11217978
103coenzyme A biosynthetic process (GO:0015937)3.07527284
104L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.06268561
105negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.05463604
106negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.03981107
107negative regulation of sister chromatid segregation (GO:0033046)3.03981107
108negative regulation of mitotic sister chromatid separation (GO:2000816)3.03981107
109negative regulation of mitotic sister chromatid segregation (GO:0033048)3.03981107
110RNA methylation (GO:0001510)3.02544236
111regulation of ubiquitin-protein transferase activity (GO:0051438)3.01999191
112DNA deamination (GO:0045006)3.01637241
113mitotic nuclear envelope disassembly (GO:0007077)3.01549171
114transcription elongation from RNA polymerase II promoter (GO:0006368)3.00706867
115sister chromatid segregation (GO:0000819)2.99890816
116oxidative demethylation (GO:0070989)2.99819413
117negative regulation of chromosome segregation (GO:0051985)2.99697572
118antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.99650382
119spliceosomal complex assembly (GO:0000245)2.99179306
120spindle assembly checkpoint (GO:0071173)2.98635308
121mitotic spindle checkpoint (GO:0071174)2.97938444
122mitochondrial respiratory chain complex I assembly (GO:0032981)2.97805391
123NADH dehydrogenase complex assembly (GO:0010257)2.97805391
124mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.97805391
125regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.97371547
126mitotic spindle assembly checkpoint (GO:0007094)2.96699597
127DNA double-strand break processing (GO:0000729)2.96214256
128regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.95978453
129C-terminal protein lipidation (GO:0006501)2.95544105
130exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.94613478
131DNA catabolic process, exonucleolytic (GO:0000738)2.94000450
132ATP synthesis coupled proton transport (GO:0015986)2.93996832
133energy coupled proton transport, down electrochemical gradient (GO:0015985)2.93996832
134transcription elongation from RNA polymerase I promoter (GO:0006362)2.93648565
135seminiferous tubule development (GO:0072520)2.93295900
136nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.92766158
137respiratory chain complex IV assembly (GO:0008535)2.92728825
138regulation of mitotic spindle organization (GO:0060236)2.92594856
139regulation of ligase activity (GO:0051340)2.91517269
140regulation of nuclear cell cycle DNA replication (GO:0033262)2.89625930
141regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.89588946
142regulation of mitotic spindle checkpoint (GO:1903504)2.89588946
143DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.89478350
144organelle fusion (GO:0048284)2.87889498
145fucose metabolic process (GO:0006004)2.87470067
146DNA demethylation (GO:0080111)2.86595173
147acrosome assembly (GO:0001675)2.85333989
148folic acid-containing compound biosynthetic process (GO:0009396)2.84785097
149platelet dense granule organization (GO:0060155)2.84325077
150mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.81638125
151protein import into peroxisome matrix (GO:0016558)2.81194462
152GPI anchor metabolic process (GO:0006505)2.80383728
153protein K6-linked ubiquitination (GO:0085020)2.79705868
154peptidyl-lysine dimethylation (GO:0018027)2.79256861
155GPI anchor biosynthetic process (GO:0006506)2.77273709
156tRNA processing (GO:0008033)2.76231325
157pteridine-containing compound biosynthetic process (GO:0042559)2.76087963
158detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.75991178
159protein targeting to mitochondrion (GO:0006626)2.75020601
160pseudouridine synthesis (GO:0001522)2.74572054
161piRNA metabolic process (GO:0034587)2.74042116
162replication fork processing (GO:0031297)2.73282918
163regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.71401336
164methionine biosynthetic process (GO:0009086)2.69408997
165tRNA modification (GO:0006400)2.68460783

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.07448463
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.67831787
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.97132655
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.86004701
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.78429300
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.77839190
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.66248996
8GATA1_22025678_ChIP-Seq_K562_Human3.63075818
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.47257605
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.41840083
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.19660403
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.18709243
13ETS1_20019798_ChIP-Seq_JURKAT_Human3.10325899
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.88962706
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.70256653
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.67721447
17* VDR_22108803_ChIP-Seq_LS180_Human2.63596990
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.61953304
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59856186
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58952250
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.56859531
22VDR_23849224_ChIP-Seq_CD4+_Human2.50519526
23ZNF274_21170338_ChIP-Seq_K562_Hela2.48322303
24ELK1_19687146_ChIP-ChIP_HELA_Human2.37394142
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.36019876
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35593931
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.33148049
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.32677232
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.30576020
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29466137
31E2F1_18555785_ChIP-Seq_MESCs_Mouse2.17634885
32SRF_21415370_ChIP-Seq_HL-1_Mouse2.16371523
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.10131579
34DCP1A_22483619_ChIP-Seq_HELA_Human2.09369308
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.09365810
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.07509739
37FOXP3_21729870_ChIP-Seq_TREG_Human2.07147060
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05995009
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04596044
40THAP11_20581084_ChIP-Seq_MESCs_Mouse2.03078093
41AR_21909140_ChIP-Seq_LNCAP_Human1.98971022
42XRN2_22483619_ChIP-Seq_HELA_Human1.98662022
43* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.97711088
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95377711
45GABP_19822575_ChIP-Seq_HepG2_Human1.88650972
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84991210
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.84689774
48* TTF2_22483619_ChIP-Seq_HELA_Human1.82632518
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.75626433
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.74215726
51TAF15_26573619_Chip-Seq_HEK293_Human1.73891812
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68893547
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.67102080
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.65175940
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62989022
56KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.62178030
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.61579053
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60662261
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58811151
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50002960
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46734722
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38863107
63IGF1R_20145208_ChIP-Seq_DFB_Human1.38719908
64P300_19829295_ChIP-Seq_ESCs_Human1.38640974
65ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.37837041
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37776228
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35174622
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32231984
69MYC_18940864_ChIP-ChIP_HL60_Human1.29734664
70ELK1_22589737_ChIP-Seq_MCF10A_Human1.24009706
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.23306146
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21253328
73* TP53_22573176_ChIP-Seq_HFKS_Human1.20766718
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20734242
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19359592
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17351061
77SALL1_21062744_ChIP-ChIP_HESCs_Human1.16509400
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13521869
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12942436
80BCAT_22108803_ChIP-Seq_LS180_Human1.12485591
81SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11256699
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11177354
83KDM5A_27292631_Chip-Seq_BREAST_Human1.11023514
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10117084
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09762295
86CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07767877
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06561019
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06407791
89CIITA_25753668_ChIP-Seq_RAJI_Human1.06291424
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06197528
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05266116
92BP1_19119308_ChIP-ChIP_Hs578T_Human1.05239589
93NFE2_27457419_Chip-Seq_LIVER_Mouse1.04299587
94IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03831398
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02637356
96EZH2_27294783_Chip-Seq_NPCs_Mouse1.02568297
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01681688
98CBP_20019798_ChIP-Seq_JUKART_Human1.01681688
99KAP1_22055183_ChIP-Seq_ESCs_Mouse1.01499746
100* ER_23166858_ChIP-Seq_MCF-7_Human1.00661503
101NANOG_19829295_ChIP-Seq_ESCs_Human0.99467812
102SOX2_19829295_ChIP-Seq_ESCs_Human0.99467812
103IRF8_21731497_ChIP-ChIP_J774_Mouse0.98553776
104HTT_18923047_ChIP-ChIP_STHdh_Human0.98061352
105TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97075969
106FUS_26573619_Chip-Seq_HEK293_Human0.96018225
107CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95933040
108EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94779568
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94425552
110EWS_26573619_Chip-Seq_HEK293_Human0.93100477
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92920216
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92920216
113FOXA1_25329375_ChIP-Seq_VCAP_Human0.92104171
114FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92104171
115SOX17_20123909_ChIP-Seq_XEN_Mouse0.90845648
116TFEB_21752829_ChIP-Seq_HELA_Human0.88702938
117AR_20517297_ChIP-Seq_VCAP_Human0.87587022
118ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86861132
119CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86550924
120SPI1_23547873_ChIP-Seq_NB4_Human0.86078091
121NOTCH1_21737748_ChIP-Seq_TLL_Human0.85444611
122TCF4_22108803_ChIP-Seq_LS180_Human0.85167694
123CRX_20693478_ChIP-Seq_RETINA_Mouse0.85143608
124EGR1_23403033_ChIP-Seq_LIVER_Mouse0.85059512
125PCGF2_27294783_Chip-Seq_NPCs_Mouse0.84796660
126NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84575261
127DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84384443
128TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.83966913
129* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83801703
130* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83764696
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82920755
132FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.82247487
133TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81111278
134NANOG_16153702_ChIP-ChIP_HESCs_Human0.80897643
135NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.78913154
136FLI1_27457419_Chip-Seq_LIVER_Mouse0.78168834
137* NANOG_21062744_ChIP-ChIP_HESCs_Human0.75706333
138POU5F1_16153702_ChIP-ChIP_HESCs_Human0.75146593
139GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.73304837
140NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.72262972
141SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.69921912
142PCGF2_27294783_Chip-Seq_ESCs_Mouse0.68736722
143* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68487629
144* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.67131118
145* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.65930751

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.08397694
2MP0010094_abnormal_chromosome_stability4.20529540
3MP0008057_abnormal_DNA_replication3.91763187
4MP0004957_abnormal_blastocyst_morpholog3.79523356
5MP0003111_abnormal_nucleus_morphology3.74385080
6MP0003077_abnormal_cell_cycle3.72158056
7MP0008058_abnormal_DNA_repair3.48503129
8MP0003718_maternal_effect3.06150581
9MP0008877_abnormal_DNA_methylation3.05148544
10MP0008932_abnormal_embryonic_tissue2.95487726
11MP0003303_peritoneal_inflammation2.84403899
12MP0008007_abnormal_cellular_replicative2.72994993
13MP0003195_calcinosis2.39618483
14MP0003123_paternal_imprinting2.32714841
15MP0002837_dystrophic_cardiac_calcinosis2.26089055
16MP0000383_abnormal_hair_follicle2.23981938
17MP0006292_abnormal_olfactory_placode2.21679729
18MP0006082_CNS_inflammation2.06837434
19MP0004147_increased_porphyrin_level2.02250745
20MP0003786_premature_aging1.97283319
21MP0003121_genomic_imprinting1.95926822
22MP0006072_abnormal_retinal_apoptosis1.93751107
23MP0008995_early_reproductive_senescence1.88445814
24MP0003806_abnormal_nucleotide_metabolis1.82819644
25MP0002102_abnormal_ear_morphology1.79621553
26MP0005084_abnormal_gallbladder_morpholo1.77323720
27MP0005253_abnormal_eye_physiology1.72541740
28MP0002876_abnormal_thyroid_physiology1.71280221
29MP0003011_delayed_dark_adaptation1.70768272
30MP0003941_abnormal_skin_development1.70574888
31MP0009697_abnormal_copulation1.66473801
32MP0001764_abnormal_homeostasis1.57726389
33MP0000350_abnormal_cell_proliferation1.57644660
34MP0003315_abnormal_perineum_morphology1.56825012
35MP0001529_abnormal_vocalization1.56773311
36MP0000566_synostosis1.53706756
37MP0001730_embryonic_growth_arrest1.52495903
38MP0010678_abnormal_skin_adnexa1.50284763
39MP0002396_abnormal_hematopoietic_system1.46632852
40MP0002234_abnormal_pharynx_morphology1.40568715
41MP0001119_abnormal_female_reproductive1.40032296
42MP0002210_abnormal_sex_determination1.38585869
43MP0009333_abnormal_splenocyte_physiolog1.37754009
44MP0003186_abnormal_redox_activity1.37030540
45MP0001664_abnormal_digestion1.36633117
46MP0000358_abnormal_cell_content/1.35605788
47MP0003787_abnormal_imprinting1.34468934
48MP0005551_abnormal_eye_electrophysiolog1.33670267
49MP0002938_white_spotting1.32094875
50MP0005379_endocrine/exocrine_gland_phen1.31285450
51MP0003136_yellow_coat_color1.28109336
52MP0002653_abnormal_ependyma_morphology1.22090247
53MP0000372_irregular_coat_pigmentation1.19244945
54MP0001697_abnormal_embryo_size1.18667778
55MP0005408_hypopigmentation1.17079546
56MP0000490_abnormal_crypts_of1.16673753
57MP0000569_abnormal_digit_pigmentation1.16162741
58MP0002277_abnormal_respiratory_mucosa1.15083312
59MP0002160_abnormal_reproductive_system1.14813915
60MP0002163_abnormal_gland_morphology1.12804997
61MP0000427_abnormal_hair_cycle1.09908027
62MP0000313_abnormal_cell_death1.09199823
63MP0001929_abnormal_gametogenesis1.09095297
64MP0006035_abnormal_mitochondrial_morpho1.08593364
65MP0008875_abnormal_xenobiotic_pharmacok1.08459047
66MP0004145_abnormal_muscle_electrophysio1.08338455
67MP0000653_abnormal_sex_gland1.07501263
68MP0001672_abnormal_embryogenesis/_devel1.07169206
69MP0005380_embryogenesis_phenotype1.07169206
70MP0001835_abnormal_antigen_presentation1.07157519
71MP0000647_abnormal_sebaceous_gland1.05508885
72MP0002638_abnormal_pupillary_reflex1.05283986
73MP0002085_abnormal_embryonic_tissue1.04114510
74MP0005075_abnormal_melanosome_morpholog1.02878841
75MP0000467_abnormal_esophagus_morphology1.02740697
76MP0002132_abnormal_respiratory_system1.02092521
77MP0003890_abnormal_embryonic-extraembry1.01627469
78MP0001145_abnormal_male_reproductive1.01471749
79MP0001663_abnormal_digestive_system1.01341586
80MP0002019_abnormal_tumor_incidence1.00961942
81MP0008789_abnormal_olfactory_epithelium1.00521707
82MP0000631_abnormal_neuroendocrine_gland1.00002544
83MP0001188_hyperpigmentation0.99870201
84MP0005646_abnormal_pituitary_gland0.99773503
85MP0005171_absent_coat_pigmentation0.99169618
86MP0008872_abnormal_physiological_respon0.97699828
87MP0005394_taste/olfaction_phenotype0.96707456
88MP0005499_abnormal_olfactory_system0.96707456
89MP0003937_abnormal_limbs/digits/tail_de0.96183528
90MP0003763_abnormal_thymus_physiology0.94928227
91MP0005174_abnormal_tail_pigmentation0.94608343
92MP0004215_abnormal_myocardial_fiber0.94464720
93MP0003880_abnormal_central_pattern0.94169891
94MP0002736_abnormal_nociception_after0.93858638
95MP0005391_vision/eye_phenotype0.93222281
96MP0005389_reproductive_system_phenotype0.92947412
97MP0008260_abnormal_autophagy0.92696161
98MP0002080_prenatal_lethality0.90858926
99MP0002148_abnormal_hypersensitivity_rea0.89968821
100MP0005395_other_phenotype0.89954655
101MP0000015_abnormal_ear_pigmentation0.88695807
102MP0003984_embryonic_growth_retardation0.87525876
103MP0005410_abnormal_fertilization0.87030613
104MP0003646_muscle_fatigue0.85629234
105MP0001293_anophthalmia0.85616562
106MP0004782_abnormal_surfactant_physiolog0.83736795
107MP0005671_abnormal_response_to0.83502209
108MP0004133_heterotaxia0.82766747
109MP0002088_abnormal_embryonic_growth/wei0.82699502
110MP0002928_abnormal_bile_duct0.78794816
111MP0002095_abnormal_skin_pigmentation0.77928404
112MP0010307_abnormal_tumor_latency0.76607117
113MP0002084_abnormal_developmental_patter0.75369252
114MP0001905_abnormal_dopamine_level0.74180689
115MP0003950_abnormal_plasma_membrane0.73913231
116MP0001286_abnormal_eye_development0.73346659
117MP0009785_altered_susceptibility_to0.72543436
118MP0005451_abnormal_body_composition0.72475056
119MP0001324_abnormal_eye_pigmentation0.71972873
120MP0003755_abnormal_palate_morphology0.71056152
121MP0002109_abnormal_limb_morphology0.70971149
122MP0004142_abnormal_muscle_tone0.70858451
123MP0002398_abnormal_bone_marrow0.70791835
124MP0006276_abnormal_autonomic_nervous0.70109124
125MP0001986_abnormal_taste_sensitivity0.70084715
126MP0003698_abnormal_male_reproductive0.69913001
127MP0000049_abnormal_middle_ear0.69763832
128MP0004808_abnormal_hematopoietic_stem0.69682126
129MP0005195_abnormal_posterior_eye0.69027481
130MP0001984_abnormal_olfaction0.68395468
131MP0001542_abnormal_bone_strength0.67715165
132MP0003699_abnormal_female_reproductive0.67533561
133MP0002751_abnormal_autonomic_nervous0.65571309
134MP0005381_digestive/alimentary_phenotyp0.64988479
135MP0003936_abnormal_reproductive_system0.64825937
136MP0002722_abnormal_immune_system0.63911139
137MP0003567_abnormal_fetal_cardiomyocyte0.63308541
138MP0000689_abnormal_spleen_morphology0.63149399
139MP0000703_abnormal_thymus_morphology0.63041041
140MP0006036_abnormal_mitochondrial_physio0.62621845
141MP0010030_abnormal_orbit_morphology0.61542367
142MP0000026_abnormal_inner_ear0.60853369
143MP0001186_pigmentation_phenotype0.59391031
144MP0003221_abnormal_cardiomyocyte_apopto0.58920157
145MP0000516_abnormal_urinary_system0.58602509
146MP0005367_renal/urinary_system_phenotyp0.58602509
147MP0000858_altered_metastatic_potential0.58015121
148MP0003942_abnormal_urinary_system0.57586256
149MP0005384_cellular_phenotype0.57410242
150MP0002429_abnormal_blood_cell0.57064187
151MP0003122_maternal_imprinting0.56156986
152MP0001919_abnormal_reproductive_system0.56100834
153MP0001853_heart_inflammation0.55745323

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.79897918
2Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.23748506
3Breast hypoplasia (HP:0003187)4.02764418
4Large for gestational age (HP:0001520)4.02388206
5Chromsome breakage (HP:0040012)3.99211429
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.68580597
7Pancreatic fibrosis (HP:0100732)3.49839490
8Long foot (HP:0001833)3.43035480
9True hermaphroditism (HP:0010459)3.41226847
10Pancreatic cysts (HP:0001737)3.36188414
11Patellar aplasia (HP:0006443)3.30200264
12Hypoplastic pelvis (HP:0008839)3.28933380
13Meckel diverticulum (HP:0002245)3.07361571
14Aplasia/Hypoplasia of the patella (HP:0006498)3.05427050
15Acute necrotizing encephalopathy (HP:0006965)3.01403898
16Cerebral hypomyelination (HP:0006808)3.00259410
17Abnormality of the ileum (HP:0001549)2.90063027
18Adrenal hypoplasia (HP:0000835)2.89048024
19Carpal bone hypoplasia (HP:0001498)2.78803203
20Lactic acidosis (HP:0003128)2.78562487
21Abnormality of the preputium (HP:0100587)2.76671449
22Acute lymphatic leukemia (HP:0006721)2.71536766
23Abnormality of fatty-acid metabolism (HP:0004359)2.71311176
24Abnormality of chromosome stability (HP:0003220)2.71202962
25Supernumerary spleens (HP:0009799)2.70324660
26Methylmalonic acidemia (HP:0002912)2.65389698
27Mitochondrial inheritance (HP:0001427)2.65094443
28Abnormality of glycolysis (HP:0004366)2.64563113
29Increased serum pyruvate (HP:0003542)2.64563113
30Aplasia/Hypoplasia of the uvula (HP:0010293)2.64302265
31Progressive muscle weakness (HP:0003323)2.63702762
32Abnormal mitochondria in muscle tissue (HP:0008316)2.62588234
33Brushfield spots (HP:0001088)2.59379095
34Cerebral edema (HP:0002181)2.58277072
35Increased CSF lactate (HP:0002490)2.57548627
36Abnormal lung lobation (HP:0002101)2.56507422
37Rough bone trabeculation (HP:0100670)2.55635052
38Degeneration of anterior horn cells (HP:0002398)2.50534393
39Abnormality of the anterior horn cell (HP:0006802)2.50534393
40Severe muscular hypotonia (HP:0006829)2.48398629
41Reticulocytopenia (HP:0001896)2.45184906
42Hepatocellular necrosis (HP:0001404)2.45175681
43Oral leukoplakia (HP:0002745)2.43140613
44Adactyly (HP:0009776)2.40880973
453-Methylglutaconic aciduria (HP:0003535)2.37650005
46Duodenal stenosis (HP:0100867)2.37122223
47Small intestinal stenosis (HP:0012848)2.37122223
48Methylmalonic aciduria (HP:0012120)2.34702504
49Abnormality of the labia minora (HP:0012880)2.33351980
50Absent radius (HP:0003974)2.33085325
51Progressive macrocephaly (HP:0004481)2.30418213
52Sloping forehead (HP:0000340)2.29959568
53Increased hepatocellular lipid droplets (HP:0006565)2.28583671
54Aplastic anemia (HP:0001915)2.28450577
55Cleft eyelid (HP:0000625)2.26729816
56Respiratory failure (HP:0002878)2.23150549
57Nephronophthisis (HP:0000090)2.22424388
58Type I transferrin isoform profile (HP:0003642)2.21417212
59Broad-based gait (HP:0002136)2.19510107
60Exertional dyspnea (HP:0002875)2.19090480
61Medial flaring of the eyebrow (HP:0010747)2.15687306
62Hyperglycinemia (HP:0002154)2.15550781
63Impulsivity (HP:0100710)2.15045461
64Bone marrow hypocellularity (HP:0005528)2.15019187
65Aplasia involving forearm bones (HP:0009822)2.14794277
66Absent forearm bone (HP:0003953)2.14794277
67Dry hair (HP:0011359)2.13937548
68Renal Fanconi syndrome (HP:0001994)2.13676079
69Aplasia/Hypoplasia of the tongue (HP:0010295)2.13643088
70Abnormal trabecular bone morphology (HP:0100671)2.12779738
71Congenital primary aphakia (HP:0007707)2.12642075
72Premature graying of hair (HP:0002216)2.12589419
73Autoamputation (HP:0001218)2.12357908
74Poor head control (HP:0002421)2.11046915
75Aplasia/Hypoplasia involving the musculature (HP:0001460)2.10272257
76Nephrogenic diabetes insipidus (HP:0009806)2.10256436
77Abnormality of the renal cortex (HP:0011035)2.09810359
78Occipital encephalocele (HP:0002085)2.09077515
79Hepatic necrosis (HP:0002605)2.08091538
80Ureteral duplication (HP:0000073)2.07323224
81Agnosia (HP:0010524)2.06424592
82Type 2 muscle fiber atrophy (HP:0003554)2.05509267
83Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.04970426
84Aplasia/Hypoplasia of the sacrum (HP:0008517)2.04729541
85Optic disc pallor (HP:0000543)2.04538208
86Increased serum lactate (HP:0002151)2.03333702
87Abnormal number of erythroid precursors (HP:0012131)2.03331403
88Abnormality of cells of the erythroid lineage (HP:0012130)2.02583515
89Molar tooth sign on MRI (HP:0002419)2.02544598
90Abnormality of midbrain morphology (HP:0002418)2.02544598
91Triphalangeal thumb (HP:0001199)2.02377883
92Acute encephalopathy (HP:0006846)2.02129734
93Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.01499003
94Preaxial hand polydactyly (HP:0001177)2.01143491
95Secondary amenorrhea (HP:0000869)1.99000856
96Optic nerve coloboma (HP:0000588)1.98206246
97Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.97881642
98Poor coordination (HP:0002370)1.97060091
99Ectopic kidney (HP:0000086)1.96693834
100CNS demyelination (HP:0007305)1.96420237
101Nephroblastoma (Wilms tumor) (HP:0002667)1.96122281
102Gait imbalance (HP:0002141)1.96103791
103Myelodysplasia (HP:0002863)1.95825162
104Horseshoe kidney (HP:0000085)1.95415428
105Anencephaly (HP:0002323)1.94763572
106Respiratory difficulties (HP:0002880)1.93797348
107Abnormality of the renal medulla (HP:0100957)1.92811940
108Aplasia/Hypoplasia of the tibia (HP:0005772)1.91130005
109Pendular nystagmus (HP:0012043)1.90500878
110Colon cancer (HP:0003003)1.89872676
111Short tibia (HP:0005736)1.89740171
112Lipid accumulation in hepatocytes (HP:0006561)1.87146988
113Muscle fiber atrophy (HP:0100295)1.87032101
114Duplicated collecting system (HP:0000081)1.86762837
115Intestinal atresia (HP:0011100)1.86043331
116Volvulus (HP:0002580)1.86041651
117Clubbing of toes (HP:0100760)1.85578436
118Embryonal renal neoplasm (HP:0011794)1.85080807
119Chorioretinal coloboma (HP:0000567)1.84414603
120Sclerocornea (HP:0000647)1.84346803
121Abnormality of the renal collecting system (HP:0004742)1.84090001
122Female pseudohermaphroditism (HP:0010458)1.83375543
123Tongue fasciculations (HP:0001308)1.81621469
124Medulloblastoma (HP:0002885)1.81600500
125Abnormality of the duodenum (HP:0002246)1.81582666
126Hypoplasia of the capital femoral epiphysis (HP:0003090)1.81184521
127Abnormal umbilical cord blood vessels (HP:0011403)1.81027333
128Single umbilical artery (HP:0001195)1.81027333
129Abnormality of the fetal cardiovascular system (HP:0010948)1.81027333
130Microretrognathia (HP:0000308)1.80894847
131Renal cortical cysts (HP:0000803)1.80496580
132Abnormality of methionine metabolism (HP:0010901)1.80447950
133Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79980751
134Abnormal protein glycosylation (HP:0012346)1.79339404
135Abnormal glycosylation (HP:0012345)1.79339404
136Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79339404
137Abnormal protein N-linked glycosylation (HP:0012347)1.79339404
138Selective tooth agenesis (HP:0001592)1.79267317
139Pulmonary artery stenosis (HP:0004415)1.78703451
140Exercise intolerance (HP:0003546)1.78696611
141Hypoplasia of the fovea (HP:0007750)1.78691492
142Aplasia/Hypoplasia of the fovea (HP:0008060)1.78691492
143Lethargy (HP:0001254)1.78532063
144Abnormality of the fovea (HP:0000493)1.78326832
145Amniotic constriction ring (HP:0009775)1.77869456
146Steatorrhea (HP:0002570)1.76258635
147Congenital stationary night blindness (HP:0007642)1.75222220
148Hypoplastic iliac wings (HP:0002866)1.72489934
149Epiphyseal stippling (HP:0010655)1.72083137
150Abnormal auditory evoked potentials (HP:0006958)1.70515833
151Type II lissencephaly (HP:0007260)1.68641460
152Absent rod-and cone-mediated responses on ERG (HP:0007688)1.67566400
153Male pseudohermaphroditism (HP:0000037)1.66299720
154Abnormal rod and cone electroretinograms (HP:0008323)1.65833449
155Increased number of teeth (HP:0011069)1.64893609
156Concave nail (HP:0001598)1.64374985
157Absent thumb (HP:0009777)1.63401890

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.06561552
2PLK43.65326434
3WEE13.37598166
4SRPK13.32815998
5EIF2AK13.25423880
6TAOK23.09595637
7TAOK13.03096672
8CDC73.00452542
9NEK12.42814531
10STK162.34041494
11PBK2.31001763
12TTK2.13281985
13ZAK2.11688161
14EIF2AK32.10642960
15FRK2.09479493
16VRK12.06886850
17BRSK22.04727544
18MAP3K32.03301821
19ACVR1B2.02332755
20MAP3K112.00218395
21PLK11.96912690
22NEK21.94682722
23PLK31.80286841
24CCNB11.77671535
25TRIM281.74779471
26MAP2K31.73709593
27MKNK11.71497596
28BRAF1.60037663
29MAP4K21.58519702
30NME21.57459270
31BMPR21.54752189
32TSSK61.53326751
33AURKB1.52365069
34VRK21.51295072
35BRSK11.49306009
36STK38L1.48631116
37ERBB31.48083556
38WNK31.46961864
39CHEK21.38512952
40PIM21.35327856
41CDK81.35296786
42IRAK41.34053907
43EIF2AK21.26900617
44PLK21.22071331
45ARAF1.21568474
46MST41.21467905
47AURKA1.16087768
48ATR1.12248120
49BMPR1B1.08983908
50INSRR1.08471599
51TLK11.08131113
52DYRK21.06135324
53DYRK31.05181529
54MKNK21.04900873
55CDK71.03776620
56DYRK1A1.02827176
57BCR1.02497201
58GRK11.00794959
59AKT30.97604731
60NUAK10.96945451
61MELK0.95710236
62MAP3K50.93057907
63STK390.92753806
64STK40.89545923
65CASK0.88247426
66TXK0.87014191
67RPS6KA40.85815569
68CHEK10.81384990
69NME10.75621335
70MUSK0.74229289
71BCKDK0.74104339
72IRAK30.73059656
73NEK60.71155802
74PASK0.69199873
75MAP3K40.68178467
76STK240.67803989
77PINK10.67726916
78OXSR10.67633904
79ABL20.67060613
80CSNK2A10.67041902
81TESK20.66328357
82MAP3K120.65738792
83RPS6KB20.65055234
84TNIK0.64825977
85WNK40.64228608
86TGFBR10.63580810
87YES10.60135637
88MAP3K140.59909720
89MAPK130.59890518
90LIMK10.58898695
91ATM0.58460764
92TEC0.58023095
93CDK30.57983360
94LATS20.57149217
95TESK10.55585638
96NEK90.55268927
97MAP3K80.54767311
98STK100.54013029
99CSNK1G10.52583299
100STK30.52445379
101RPS6KA50.51102897
102MAP3K60.50174306
103OBSCN0.49137870
104PDK20.47793290
105PAK10.47675247
106IKBKB0.47072715
107CDK10.47047961
108MOS0.46839296
109PRKCQ0.46318150
110TAF10.46032436
111MYLK0.45417840
112CSNK1G30.45309935
113PIM10.43916034
114PRKCI0.43775785
115CSNK2A20.43600315
116CDK20.43350466
117GRK70.42989768
118TRPM70.41329436
119SIK30.38837703
120CAMKK20.38253566
121ADRBK20.36722735
122MAP2K70.34538342
123CLK10.34118674
124CSNK1A10.33942041
125PRKCE0.33861726
126CSNK1G20.33660861
127JAK30.31788588
128RAF10.31302260
129CDK40.30942415
130ERBB40.27723049
131CSNK1A1L0.27425367
132PAK30.26360548
133PRKCG0.23405842
134CSNK1E0.21206361
135ADRBK10.21102311
136TIE10.18159101
137FLT30.18074760
138ABL10.17803128

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.40963171
2DNA replication_Homo sapiens_hsa030304.15407935
3Mismatch repair_Homo sapiens_hsa034303.72937084
4RNA polymerase_Homo sapiens_hsa030203.69883876
5Homologous recombination_Homo sapiens_hsa034403.19636207
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.16002729
7Ribosome_Homo sapiens_hsa030103.01315602
8Spliceosome_Homo sapiens_hsa030402.82021227
9Nucleotide excision repair_Homo sapiens_hsa034202.81201075
10RNA transport_Homo sapiens_hsa030132.65658566
11Cell cycle_Homo sapiens_hsa041102.65021516
12Base excision repair_Homo sapiens_hsa034102.64935366
13Basal transcription factors_Homo sapiens_hsa030222.51709957
14Fanconi anemia pathway_Homo sapiens_hsa034602.46815804
15Pyrimidine metabolism_Homo sapiens_hsa002402.41410960
16Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.36850546
17Non-homologous end-joining_Homo sapiens_hsa034502.29606931
18RNA degradation_Homo sapiens_hsa030182.14059029
19Butanoate metabolism_Homo sapiens_hsa006502.06920562
20Protein export_Homo sapiens_hsa030602.00536149
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98898342
22Propanoate metabolism_Homo sapiens_hsa006401.96892722
23Fatty acid elongation_Homo sapiens_hsa000621.95176067
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.75726840
25Oxidative phosphorylation_Homo sapiens_hsa001901.75172482
26Parkinsons disease_Homo sapiens_hsa050121.60772779
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51510777
28p53 signaling pathway_Homo sapiens_hsa041151.51452173
29Huntingtons disease_Homo sapiens_hsa050161.50765576
30Purine metabolism_Homo sapiens_hsa002301.47949419
31One carbon pool by folate_Homo sapiens_hsa006701.45610806
32mRNA surveillance pathway_Homo sapiens_hsa030151.36174234
33Selenocompound metabolism_Homo sapiens_hsa004501.27819324
34Tryptophan metabolism_Homo sapiens_hsa003801.25024479
35Peroxisome_Homo sapiens_hsa041461.21989584
36Epstein-Barr virus infection_Homo sapiens_hsa051691.21969326
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.21665236
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18614254
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06299259
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.04790010
41Sulfur metabolism_Homo sapiens_hsa009201.00144760
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96774122
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94536043
44Alzheimers disease_Homo sapiens_hsa050100.91644953
45Caffeine metabolism_Homo sapiens_hsa002320.91505496
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90631440
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90373919
48Oocyte meiosis_Homo sapiens_hsa041140.89043329
49Vitamin B6 metabolism_Homo sapiens_hsa007500.84931938
50Arachidonic acid metabolism_Homo sapiens_hsa005900.84900999
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84277738
52Allograft rejection_Homo sapiens_hsa053300.83925615
53Herpes simplex infection_Homo sapiens_hsa051680.82428877
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81794078
55Taste transduction_Homo sapiens_hsa047420.79558718
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78010201
57Nitrogen metabolism_Homo sapiens_hsa009100.74723009
58beta-Alanine metabolism_Homo sapiens_hsa004100.73356144
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.71996727
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.71726783
61Graft-versus-host disease_Homo sapiens_hsa053320.71451620
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67096500
63Fatty acid metabolism_Homo sapiens_hsa012120.65306840
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64707071
65Legionellosis_Homo sapiens_hsa051340.63703245
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.63527177
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62921842
68Systemic lupus erythematosus_Homo sapiens_hsa053220.62134013
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61146781
70Autoimmune thyroid disease_Homo sapiens_hsa053200.59879823
71Glutathione metabolism_Homo sapiens_hsa004800.59570449
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58412044
73Asthma_Homo sapiens_hsa053100.56964084
74Antigen processing and presentation_Homo sapiens_hsa046120.56839071
75Fatty acid degradation_Homo sapiens_hsa000710.56598017
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.55985011
77Lysine degradation_Homo sapiens_hsa003100.55449460
78Chemical carcinogenesis_Homo sapiens_hsa052040.55425090
79Primary immunodeficiency_Homo sapiens_hsa053400.55015429
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.53138448
81Viral carcinogenesis_Homo sapiens_hsa052030.51970811
82Type I diabetes mellitus_Homo sapiens_hsa049400.51745953
83Ether lipid metabolism_Homo sapiens_hsa005650.51421799
84Retinol metabolism_Homo sapiens_hsa008300.50739857
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49018562
86HTLV-I infection_Homo sapiens_hsa051660.48996207
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48807284
88Pyruvate metabolism_Homo sapiens_hsa006200.47596527
89TGF-beta signaling pathway_Homo sapiens_hsa043500.46712995
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46508273
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45725400
92Rheumatoid arthritis_Homo sapiens_hsa053230.45546858
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43316892
94Regulation of autophagy_Homo sapiens_hsa041400.42874949
95Shigellosis_Homo sapiens_hsa051310.42618337
96Measles_Homo sapiens_hsa051620.41867326
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.41263362
98Pentose phosphate pathway_Homo sapiens_hsa000300.40659936
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39763562
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39161525
101Folate biosynthesis_Homo sapiens_hsa007900.38439707
102Phagosome_Homo sapiens_hsa041450.38144935
103Glycerolipid metabolism_Homo sapiens_hsa005610.37506152
104Linoleic acid metabolism_Homo sapiens_hsa005910.37092923
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36810238
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36709754
107Steroid biosynthesis_Homo sapiens_hsa001000.36215002
108Sphingolipid metabolism_Homo sapiens_hsa006000.35510135
109Metabolic pathways_Homo sapiens_hsa011000.33922100
110Sulfur relay system_Homo sapiens_hsa041220.33214070
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32768438
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.32641873
113Olfactory transduction_Homo sapiens_hsa047400.32514247
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32413679
115MicroRNAs in cancer_Homo sapiens_hsa052060.29213104
116Cardiac muscle contraction_Homo sapiens_hsa042600.28191588
117Hematopoietic cell lineage_Homo sapiens_hsa046400.28120158
118Carbon metabolism_Homo sapiens_hsa012000.27652387
119Apoptosis_Homo sapiens_hsa042100.26789120
120Hedgehog signaling pathway_Homo sapiens_hsa043400.25156645
121Hippo signaling pathway_Homo sapiens_hsa043900.24809653
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24732101
123Influenza A_Homo sapiens_hsa051640.23849769
124Phototransduction_Homo sapiens_hsa047440.22640951
125N-Glycan biosynthesis_Homo sapiens_hsa005100.21814493
126Vibrio cholerae infection_Homo sapiens_hsa051100.21557929
127Malaria_Homo sapiens_hsa051440.21380253
128Other glycan degradation_Homo sapiens_hsa005110.20856889
129Hepatitis B_Homo sapiens_hsa051610.20562428
130Basal cell carcinoma_Homo sapiens_hsa052170.20501803
131Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.18518489
132Notch signaling pathway_Homo sapiens_hsa043300.18491333
133Collecting duct acid secretion_Homo sapiens_hsa049660.18125933
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16491603
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15843251
136Viral myocarditis_Homo sapiens_hsa054160.14375080
137Alcoholism_Homo sapiens_hsa050340.14075722
138Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.12482809
139ABC transporters_Homo sapiens_hsa020100.12446355
140Biosynthesis of amino acids_Homo sapiens_hsa012300.11558391
141Leishmaniasis_Homo sapiens_hsa051400.11407956
142Fructose and mannose metabolism_Homo sapiens_hsa000510.10404756
143Drug metabolism - other enzymes_Homo sapiens_hsa009830.09721723

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