NSMF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is involved in guidance of olfactory axon projections and migration of luteinizing hormone-releasing hormone neurons. Defects in this gene are a cause of idiopathic hypogonadotropic hypogonadism (IHH). Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.26475230
2locomotory exploration behavior (GO:0035641)6.06963357
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.99523214
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.68898446
5glutamate secretion (GO:0014047)5.30099515
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.29461678
7vocalization behavior (GO:0071625)5.22460886
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.15794900
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.12018607
10synaptic vesicle exocytosis (GO:0016079)4.99505929
11regulation of glutamate receptor signaling pathway (GO:1900449)4.93026558
12exploration behavior (GO:0035640)4.61502216
13regulation of synaptic vesicle exocytosis (GO:2000300)4.61042923
14* regulation of neuronal synaptic plasticity (GO:0048168)4.60616863
15regulation of long-term neuronal synaptic plasticity (GO:0048169)4.44324367
16cerebellar granule cell differentiation (GO:0021707)4.42682006
17protein localization to synapse (GO:0035418)4.41279398
18regulation of synapse structural plasticity (GO:0051823)4.37047685
19neurotransmitter-gated ion channel clustering (GO:0072578)4.36603593
20layer formation in cerebral cortex (GO:0021819)4.34388823
21dendritic spine morphogenesis (GO:0060997)4.29369343
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.28600980
23regulation of synaptic vesicle transport (GO:1902803)4.20051521
24neurotransmitter secretion (GO:0007269)4.17508348
25axon ensheathment in central nervous system (GO:0032291)4.17069703
26central nervous system myelination (GO:0022010)4.17069703
27cytoskeletal anchoring at plasma membrane (GO:0007016)4.02581194
28synaptic transmission, glutamatergic (GO:0035249)3.92353705
29gamma-aminobutyric acid transport (GO:0015812)3.89438600
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.86781095
31proline transport (GO:0015824)3.85564086
32neuronal action potential propagation (GO:0019227)3.84793490
33sodium ion export (GO:0071436)3.84558318
34long-term memory (GO:0007616)3.77508826
35regulation of dendritic spine morphogenesis (GO:0061001)3.76794171
36neuron cell-cell adhesion (GO:0007158)3.72415854
37cellular potassium ion homeostasis (GO:0030007)3.71565703
38regulation of synapse maturation (GO:0090128)3.70954657
39positive regulation of membrane potential (GO:0045838)3.70650167
40glutamate receptor signaling pathway (GO:0007215)3.66542221
41regulation of excitatory postsynaptic membrane potential (GO:0060079)3.56407437
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.54368182
43* regulation of synaptic plasticity (GO:0048167)3.53217653
44potassium ion homeostasis (GO:0055075)3.53196280
45positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.50185663
46positive regulation of synapse maturation (GO:0090129)3.48004171
47neuromuscular process controlling balance (GO:0050885)3.45322287
48negative regulation of dendrite morphogenesis (GO:0050774)3.43949303
49neuron-neuron synaptic transmission (GO:0007270)3.42455769
50activation of protein kinase A activity (GO:0034199)3.39940945
51dendrite morphogenesis (GO:0048813)3.37549008
52L-amino acid import (GO:0043092)3.36583527
53cell communication by electrical coupling (GO:0010644)3.36151058
54cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.34924025
55cell migration in hindbrain (GO:0021535)3.32723233
56regulation of postsynaptic membrane potential (GO:0060078)3.31656864
57positive regulation of dendritic spine development (GO:0060999)3.31128527
58dendritic spine organization (GO:0097061)3.26943098
59neurotransmitter transport (GO:0006836)3.25647204
60regulation of ARF protein signal transduction (GO:0032012)3.23229625
61synaptic vesicle endocytosis (GO:0048488)3.20816731
62regulation of dendritic spine development (GO:0060998)3.16786975
63neuron recognition (GO:0008038)3.16215924
64alanine transport (GO:0032328)3.15079348
65negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.14543733
66long-term synaptic potentiation (GO:0060291)3.13700112
67regulation of neurotransmitter levels (GO:0001505)3.11983721
68negative regulation of catenin import into nucleus (GO:0035414)3.11868712
69auditory behavior (GO:0031223)3.11364989
70G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.10966466
71positive regulation of dendrite development (GO:1900006)3.10200352
72regulation of neurotransmitter secretion (GO:0046928)3.08586344
73axonal fasciculation (GO:0007413)3.06887512
74mating behavior (GO:0007617)3.04741967
75glycine transport (GO:0015816)3.04459407
76positive regulation of synaptic transmission, GABAergic (GO:0032230)3.04006406
77transmission of nerve impulse (GO:0019226)3.03272511
78neuronal ion channel clustering (GO:0045161)3.03197737
79positive regulation of dendritic spine morphogenesis (GO:0061003)3.02337012
80cellular sodium ion homeostasis (GO:0006883)3.02091563
81regulation of synaptic transmission, glutamatergic (GO:0051966)3.01423605
82response to auditory stimulus (GO:0010996)3.00750594
83regulation of female receptivity (GO:0045924)2.95910004
84innervation (GO:0060384)2.94694088
85positive regulation of neurotransmitter secretion (GO:0001956)2.94421828
86regulation of vesicle fusion (GO:0031338)2.93553374
87dicarboxylic acid transport (GO:0006835)2.91880329
88postsynaptic membrane organization (GO:0001941)2.88687039
89regulation of neurotransmitter transport (GO:0051588)2.84392399
90neuromuscular process controlling posture (GO:0050884)2.84239043
91regulation of voltage-gated calcium channel activity (GO:1901385)2.83460836
92cerebellar Purkinje cell layer development (GO:0021680)2.82555690
93prepulse inhibition (GO:0060134)2.82071012
94positive regulation of synaptic transmission (GO:0050806)2.82010754
95cell-cell junction maintenance (GO:0045217)2.81111571
96positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.80487144
97regulation of mammary gland epithelial cell proliferation (GO:0033599)2.80170259
98* regulation of synaptic transmission (GO:0050804)2.79381199
99membrane depolarization (GO:0051899)2.79213391
100positive regulation of neurotransmitter transport (GO:0051590)2.78731566
101vesicle transport along microtubule (GO:0047496)2.78005784
102regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.75975356
103negative regulation of synaptic transmission, GABAergic (GO:0032229)2.75961688
104learning (GO:0007612)2.75710069
105acidic amino acid transport (GO:0015800)2.75552406
106chemosensory behavior (GO:0007635)2.73837387
107social behavior (GO:0035176)2.73385206
108intraspecies interaction between organisms (GO:0051703)2.73385206
109establishment of mitochondrion localization (GO:0051654)2.72307524
110dopamine receptor signaling pathway (GO:0007212)2.71724819
111behavioral fear response (GO:0001662)2.71453361
112behavioral defense response (GO:0002209)2.71453361
113membrane depolarization during action potential (GO:0086010)2.71205725
114neuromuscular process (GO:0050905)2.70466875
115regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.69970252
116regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.68932417
117regulation of ARF GTPase activity (GO:0032312)2.68828701
118cerebellar Purkinje cell differentiation (GO:0021702)2.68415036
119potassium ion import (GO:0010107)2.64846748
120peptidyl-tyrosine autophosphorylation (GO:0038083)2.64592033
121protein targeting to plasma membrane (GO:0072661)2.63381829
122regulation of early endosome to late endosome transport (GO:2000641)2.62425851
123amino acid import (GO:0043090)2.61648922
124* regulation of dendrite morphogenesis (GO:0048814)2.61636982
125positive regulation of fibroblast migration (GO:0010763)2.61184378
126mitochondrion transport along microtubule (GO:0047497)2.55617197
127establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.55617197
128myelin maintenance (GO:0043217)2.53335385
129* regulation of dendrite development (GO:0050773)2.51187376

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.34274759
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.94108284
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.90268794
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.85720672
5DROSHA_22980978_ChIP-Seq_HELA_Human2.71067847
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69813002
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69813002
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.67669314
9GBX2_23144817_ChIP-Seq_PC3_Human2.67454721
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58151626
11REST_21632747_ChIP-Seq_MESCs_Mouse2.55849810
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53562516
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.53325660
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47635894
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47120703
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.44245013
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.32573154
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31622646
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28880848
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.28672420
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.26373882
22TP63_17297297_ChIP-ChIP_HaCaT_Human2.17517044
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.17308233
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.15606824
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.14342435
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.14030036
27ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.04482301
28IKZF1_21737484_ChIP-ChIP_HCT116_Human2.03849942
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.88152628
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.84801777
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.80863088
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.77673078
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77027821
34KDM2B_26808549_Chip-Seq_DND41_Human1.75880057
35SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.75811308
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.74354085
37AR_21572438_ChIP-Seq_LNCaP_Human1.74040175
38RACK7_27058665_Chip-Seq_MCF-7_Human1.66717206
39P68_20966046_ChIP-Seq_HELA_Human1.59813841
40UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.59529327
41TET1_21451524_ChIP-Seq_MESCs_Mouse1.57196236
42SRY_22984422_ChIP-ChIP_TESTIS_Rat1.56003166
43TCF7_22412390_ChIP-Seq_EML_Mouse1.54075401
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53937298
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52940324
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.52536529
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.52092019
48CREB1_26743006_Chip-Seq_LNCaP_Human1.45513083
49KDM2B_26808549_Chip-Seq_JURKAT_Human1.44257757
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.42383400
51SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41192183
52KDM2B_26808549_Chip-Seq_K562_Human1.39505213
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34761849
54ZNF263_19887448_ChIP-Seq_K562_Human1.33829885
55MYC_22102868_ChIP-Seq_BL_Human1.32387972
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32062731
57EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31086750
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30796880
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30678934
60SA1_27219007_Chip-Seq_ERYTHROID_Human1.30428051
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29968334
62RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29954755
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28733980
64WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28540109
65WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28222681
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27643845
67SMAD4_21799915_ChIP-Seq_A2780_Human1.24589981
68VDR_21846776_ChIP-Seq_THP-1_Human1.24403109
69CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23525225
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22174700
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20028793
72CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19761530
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19104388
74PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18628978
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17967538
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.17030548
77AR_19668381_ChIP-Seq_PC3_Human1.15863675
78ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14547495
79SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.14522851
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14389495
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13797938
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13490803
83RING1B_27294783_Chip-Seq_NPCs_Mouse1.13150283
84MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.12373055
85PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11422486
86P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09712301
87TP53_20018659_ChIP-ChIP_R1E_Mouse1.09298482
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09100447
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08903835
90SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05929441
91OCT4_19829295_ChIP-Seq_ESCs_Human1.05519676
92ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05290047
93KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05233481
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05157204
95CTCF_27219007_Chip-Seq_Bcells_Human1.03587236
96RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03251451
97CLOCK_20551151_ChIP-Seq_293T_Human1.01795808
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01384616
99ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01277194
100TRIM28_21343339_ChIP-Seq_HEK293_Human1.01178821
101CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00737689
102CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00242951
103AR_25329375_ChIP-Seq_VCAP_Human0.99411424
104ZNF274_21170338_ChIP-Seq_K562_Hela0.99250387
105NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97863658
106LXR_22292898_ChIP-Seq_THP-1_Human0.97567743
107ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97458160
108KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97040386
109TP53_23651856_ChIP-Seq_MEFs_Mouse0.96251349
110ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.95920927
111NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95876817
112ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95874027
113SMAD3_21741376_ChIP-Seq_EPCs_Human0.95777854
114SMAD4_21741376_ChIP-Seq_HESCs_Human0.95054833
115VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94690128
116GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.94634541
117TET1_21490601_ChIP-Seq_MESCs_Mouse0.93621160
118TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.93113492
119STAT3_23295773_ChIP-Seq_U87_Human0.93108819
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91296462
121P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90894276
122ARNT_22903824_ChIP-Seq_MCF-7_Human0.90159511
123CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89796904
124NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89122113
125PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88517027
126AHR_22903824_ChIP-Seq_MCF-7_Human0.87350367
127YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87298367
128P300_19829295_ChIP-Seq_ESCs_Human0.87000455
129RXR_22108803_ChIP-Seq_LS180_Human0.86823251
130MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86821581
131SMAD3_21741376_ChIP-Seq_HESCs_Human0.86757753
132TAF15_26573619_Chip-Seq_HEK293_Human0.86706585
133FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86481531
134BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86108319
135RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85275503
136TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85019006
137SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84258892
138ESR2_21235772_ChIP-Seq_MCF-7_Human0.84051005
139CBX2_27304074_Chip-Seq_ESCs_Mouse0.83698427
140PIAS1_25552417_ChIP-Seq_VCAP_Human0.83557265
141DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83469783
142SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83378321
143KLF4_19829295_ChIP-Seq_ESCs_Human0.83114301
144OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81774071
145TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81331351
146SMAD3_21741376_ChIP-Seq_ESCs_Human0.81038813
147SMC4_20622854_ChIP-Seq_HELA_Human0.80138352
148OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.79556937

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.73877440
2MP0003880_abnormal_central_pattern4.26111310
3MP0003635_abnormal_synaptic_transmissio4.22419369
4MP0004270_analgesia3.75642591
5MP0002063_abnormal_learning/memory/cond3.41515037
6MP0009745_abnormal_behavioral_response3.27248908
7MP0002064_seizures3.06886573
8MP0002822_catalepsy2.83919001
9MP0005423_abnormal_somatic_nervous2.67728795
10MP0002572_abnormal_emotion/affect_behav2.60874887
11MP0001968_abnormal_touch/_nociception2.54640301
12MP0001486_abnormal_startle_reflex2.53112764
13MP0009780_abnormal_chondrocyte_physiolo2.49785966
14MP0009046_muscle_twitch2.46837681
15MP0003329_amyloid_beta_deposits2.43105469
16MP0003705_abnormal_hypodermis_morpholog2.41814144
17MP0002734_abnormal_mechanical_nocicepti2.36637253
18MP0003123_paternal_imprinting2.33598470
19MP0002272_abnormal_nervous_system2.31861015
20MP0004858_abnormal_nervous_system2.20165155
21MP0001501_abnormal_sleep_pattern2.05383866
22MP0001440_abnormal_grooming_behavior1.90547760
23MP0008569_lethality_at_weaning1.86232914
24MP0002909_abnormal_adrenal_gland1.85170144
25MP0002736_abnormal_nociception_after1.85053403
26MP0002735_abnormal_chemical_nociception1.82750718
27MP0004885_abnormal_endolymph1.81887460
28MP0004811_abnormal_neuron_physiology1.81159063
29MP0002733_abnormal_thermal_nociception1.80194706
30MP0005409_darkened_coat_color1.79605296
31MP0002249_abnormal_larynx_morphology1.76525017
32MP0000566_synostosis1.74631478
33MP0000778_abnormal_nervous_system1.74141003
34MP0001348_abnormal_lacrimal_gland1.70977682
35MP0001970_abnormal_pain_threshold1.69472589
36MP0002557_abnormal_social/conspecific_i1.63076948
37MP0005646_abnormal_pituitary_gland1.62705389
38MP0003879_abnormal_hair_cell1.61675202
39MP0002067_abnormal_sensory_capabilities1.58725850
40MP0003075_altered_response_to1.54265170
41MP0003633_abnormal_nervous_system1.52149928
42MP0000955_abnormal_spinal_cord1.52015821
43MP0002184_abnormal_innervation1.50857096
44MP0003690_abnormal_glial_cell1.41558463
45MP0004924_abnormal_behavior1.41511523
46MP0005386_behavior/neurological_phenoty1.41511523
47MP0001984_abnormal_olfaction1.40781604
48MP0001346_abnormal_lacrimal_gland1.38277531
49MP0000604_amyloidosis1.37442749
50MP0002882_abnormal_neuron_morphology1.34959413
51MP0002066_abnormal_motor_capabilities/c1.33981539
52MP0003631_nervous_system_phenotype1.26445911
53MP0001502_abnormal_circadian_rhythm1.25192211
54MP0005645_abnormal_hypothalamus_physiol1.22934236
55MP0002139_abnormal_hepatobiliary_system1.20696767
56MP0005085_abnormal_gallbladder_physiolo1.10120341
57MP0001849_ear_inflammation1.08756104
58MP0005360_urolithiasis1.07784622
59MP0008961_abnormal_basal_metabolism1.07690290
60MP0010234_abnormal_vibrissa_follicle1.06541899
61MP0002152_abnormal_brain_morphology1.04947686
62MP0000678_abnormal_parathyroid_gland1.04480286
63MP0001177_atelectasis1.04180177
64MP0008874_decreased_physiological_sensi1.01426548
65MP0002069_abnormal_eating/drinking_beha1.01131824
66MP0005076_abnormal_cell_differentiation1.00522014
67MP0000920_abnormal_myelination0.99840330
68MP0006276_abnormal_autonomic_nervous0.99006293
69MP0005167_abnormal_blood-brain_barrier0.98621594
70MP0005535_abnormal_body_temperature0.97686641
71MP0003283_abnormal_digestive_organ0.97530058
72MP0003787_abnormal_imprinting0.95539183
73MP0008872_abnormal_physiological_respon0.93944936
74MP0003634_abnormal_glial_cell0.93754107
75MP0000579_abnormal_nail_morphology0.93198155
76MP0003632_abnormal_nervous_system0.92617001
77MP0000751_myopathy0.92566693
78MP0002090_abnormal_vision0.89916642
79MP0000537_abnormal_urethra_morphology0.88401838
80MP0002229_neurodegeneration0.87867725
81MP0001905_abnormal_dopamine_level0.85930131
82MP0004142_abnormal_muscle_tone0.85587395
83MP0003861_abnormal_nervous_system0.85344598
84MP0010329_abnormal_lipoprotein_level0.84485616
85MP0004130_abnormal_muscle_cell0.83193750
86MP0005365_abnormal_bile_salt0.82494378
87MP0000534_abnormal_ureter_morphology0.81862891
88MP0008260_abnormal_autophagy0.81270480
89MP0005058_abnormal_lysosome_morphology0.78059271
90MP0003172_abnormal_lysosome_physiology0.77145462
91MP0009672_abnormal_birth_weight0.76110731
92MP0000569_abnormal_digit_pigmentation0.73752301
93MP0003938_abnormal_ear_development0.73074167
94MP0004085_abnormal_heartbeat0.72357546
95MP0005166_decreased_susceptibility_to0.71452890
96MP0003183_abnormal_peptide_metabolism0.70159399
97MP0008875_abnormal_xenobiotic_pharmacok0.70121315
98MP0009379_abnormal_foot_pigmentation0.68606479
99MP0005551_abnormal_eye_electrophysiolog0.68541385
100MP0001943_abnormal_respiration0.68372025
101MP0004510_myositis0.67937126
102MP0004185_abnormal_adipocyte_glucose0.66894953
103MP0001963_abnormal_hearing_physiology0.65967082
104MP0003942_abnormal_urinary_system0.65098717
105MP0003252_abnormal_bile_duct0.62910223
106MP0000013_abnormal_adipose_tissue0.62847764
107MP0005257_abnormal_intraocular_pressure0.62381240
108MP0003137_abnormal_impulse_conducting0.62022920
109MP0001731_abnormal_postnatal_growth0.61202031
110MP0010769_abnormal_survival0.61135440
111MP0003115_abnormal_respiratory_system0.61030709
112MP0005499_abnormal_olfactory_system0.60331448
113MP0005394_taste/olfaction_phenotype0.60331448
114MP0000762_abnormal_tongue_morphology0.58725196
115MP0003122_maternal_imprinting0.58624764
116MP0003566_abnormal_cell_adhesion0.57569661
117MP0005623_abnormal_meninges_morphology0.57494932
118MP0001299_abnormal_eye_distance/0.57183816
119MP0010770_preweaning_lethality0.56998120
120MP0002082_postnatal_lethality0.56998120
121MP0000003_abnormal_adipose_tissue0.56868751
122MP0005584_abnormal_enzyme/coenzyme_acti0.56720458
123MP0001529_abnormal_vocalization0.56622940
124MP0000681_abnormal_thyroid_gland0.56425732
125MP0000747_muscle_weakness0.56257877
126MP0003385_abnormal_body_wall0.55982780
127MP0002118_abnormal_lipid_homeostasis0.55804078
128MP0002752_abnormal_somatic_nervous0.55540169
129MP0001664_abnormal_digestion0.55404173
130MP0004043_abnormal_pH_regulation0.54498924
131MP0002089_abnormal_postnatal_growth/wei0.52009133
132MP0001485_abnormal_pinna_reflex0.51572353
133MP0002837_dystrophic_cardiac_calcinosis0.51404413
134MP0005187_abnormal_penis_morphology0.51398485
135MP0000631_abnormal_neuroendocrine_gland0.49652821
136MP0004742_abnormal_vestibular_system0.48916691

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.64464606
2Focal motor seizures (HP:0011153)6.68335757
3Focal seizures (HP:0007359)5.17227344
4Visual hallucinations (HP:0002367)4.97449190
5Hyperacusis (HP:0010780)4.06003970
6Epileptic encephalopathy (HP:0200134)4.02816123
7Action tremor (HP:0002345)4.01079940
8Supranuclear gaze palsy (HP:0000605)3.88689931
9Ankle clonus (HP:0011448)3.72493063
10Progressive cerebellar ataxia (HP:0002073)3.71987190
11Impaired vibration sensation in the lower limbs (HP:0002166)3.58754243
12Generalized tonic-clonic seizures (HP:0002069)3.54968620
13Abnormality of the lower motor neuron (HP:0002366)3.52475622
14Atonic seizures (HP:0010819)3.46139452
15Absence seizures (HP:0002121)3.43882286
16Neurofibrillary tangles (HP:0002185)3.39234547
17Febrile seizures (HP:0002373)3.38984211
18Depression (HP:0000716)3.37307946
19Postural instability (HP:0002172)3.28853220
20Torticollis (HP:0000473)3.28709814
21Poor eye contact (HP:0000817)3.27618694
22Megalencephaly (HP:0001355)3.22043033
23Cerebral inclusion bodies (HP:0100314)3.19411612
24Dialeptic seizures (HP:0011146)3.17202067
25Focal dystonia (HP:0004373)3.13388515
26Papilledema (HP:0001085)3.12676959
27Dysmetria (HP:0001310)3.12555479
28Impaired social interactions (HP:0000735)3.09615103
29Abnormal social behavior (HP:0012433)3.09615103
30Urinary bladder sphincter dysfunction (HP:0002839)3.04291543
31Dysdiadochokinesis (HP:0002075)3.01037236
32Abnormal eating behavior (HP:0100738)2.99557104
33Anxiety (HP:0000739)2.96990614
34Intention tremor (HP:0002080)2.96882471
35Mutism (HP:0002300)2.92075859
36Bronchomalacia (HP:0002780)2.82000277
37Urinary urgency (HP:0000012)2.80507066
38Craniofacial dystonia (HP:0012179)2.78855018
39Broad-based gait (HP:0002136)2.78237801
40Spastic gait (HP:0002064)2.75673287
41Hemiplegia (HP:0002301)2.75457789
42Overriding aorta (HP:0002623)2.75075807
43Hyperventilation (HP:0002883)2.69306625
44Elfin facies (HP:0004428)2.62862242
45Gaze-evoked nystagmus (HP:0000640)2.60519139
46Ventricular fibrillation (HP:0001663)2.58402408
47Upper limb amyotrophy (HP:0009129)2.58040291
48Distal upper limb amyotrophy (HP:0007149)2.58040291
49Status epilepticus (HP:0002133)2.57848878
50Amblyopia (HP:0000646)2.56622347
51Renal duplication (HP:0000075)2.55313354
52Genetic anticipation (HP:0003743)2.53585419
53Bradykinesia (HP:0002067)2.52064940
54Insomnia (HP:0100785)2.51789089
55Impaired vibratory sensation (HP:0002495)2.50300097
56Hemiparesis (HP:0001269)2.49166408
57Truncal ataxia (HP:0002078)2.45449296
58Lower limb amyotrophy (HP:0007210)2.43398331
59Peripheral hypomyelination (HP:0007182)2.37317771
60Shallow orbits (HP:0000586)2.35995145
61Annular pancreas (HP:0001734)2.35889135
62Stereotypic behavior (HP:0000733)2.33839415
63Epileptiform EEG discharges (HP:0011182)2.33420382
64Scanning speech (HP:0002168)2.32971281
65Drooling (HP:0002307)2.32768875
66Excessive salivation (HP:0003781)2.32768875
67Akinesia (HP:0002304)2.32720991
68Lower limb muscle weakness (HP:0007340)2.30221162
69Bundle branch block (HP:0011710)2.30116271
70EEG with generalized epileptiform discharges (HP:0011198)2.29256186
71Insidious onset (HP:0003587)2.28415860
72Termporal pattern (HP:0011008)2.28415860
73Hypsarrhythmia (HP:0002521)2.26448563
74Renovascular hypertension (HP:0100817)2.24549659
75Cerebral aneurysm (HP:0004944)2.23029631
76Generalized myoclonic seizures (HP:0002123)2.22256010
77Impaired smooth pursuit (HP:0007772)2.22250837
78Broad face (HP:0000283)2.21479274
79Abnormality of binocular vision (HP:0011514)2.19397580
80Diplopia (HP:0000651)2.19397580
81Pointed chin (HP:0000307)2.18805310
82Clonus (HP:0002169)2.14011595
83Obstructive sleep apnea (HP:0002870)2.12772957
84Hand muscle atrophy (HP:0009130)2.12192510
85Abnormality of the corticospinal tract (HP:0002492)2.11165701
86Truncus arteriosus (HP:0001660)2.08966915
87Agitation (HP:0000713)2.04854364
88Abnormality of the periventricular white matter (HP:0002518)2.03880726
89Ulnar bowing (HP:0003031)2.03290540
90Rigidity (HP:0002063)1.98740261
91Premature skin wrinkling (HP:0100678)1.98083341
92Abnormality of ocular smooth pursuit (HP:0000617)1.97678980
93Arnold-Chiari malformation (HP:0002308)1.95376783
94Spinal canal stenosis (HP:0003416)1.94893267
95Aplasia involving bones of the extremities (HP:0009825)1.94670933
96Aplasia involving bones of the upper limbs (HP:0009823)1.94670933
97Aplasia of the phalanges of the hand (HP:0009802)1.94670933
98Deep venous thrombosis (HP:0002625)1.93568907
99Sleep apnea (HP:0010535)1.92726383
100Diminished motivation (HP:0000745)1.92670957
101Hyperparathyroidism (HP:0000843)1.91374180
102Progressive inability to walk (HP:0002505)1.91125114
103Spastic tetraparesis (HP:0001285)1.89412953
104Fetal akinesia sequence (HP:0001989)1.88371544
105Abnormality of the Achilles tendon (HP:0005109)1.87473564
106Neuronal loss in central nervous system (HP:0002529)1.84173461
107Rapidly progressive (HP:0003678)1.82236861
108Delusions (HP:0000746)1.81687965
109Dysmetric saccades (HP:0000641)1.81646922
110Gait ataxia (HP:0002066)1.81608594
111Flat cornea (HP:0007720)1.81296102
112Polyphagia (HP:0002591)1.81281639
113Protrusio acetabuli (HP:0003179)1.80254651
114Lower limb asymmetry (HP:0100559)1.80249313
115Blue irides (HP:0000635)1.80116621
116Achilles tendon contracture (HP:0001771)1.79221811
117Turricephaly (HP:0000262)1.78467832
118Apathy (HP:0000741)1.77009057
119Abnormality of the aortic arch (HP:0012303)1.76017320
120Incomplete penetrance (HP:0003829)1.75523330
121Mitral regurgitation (HP:0001653)1.75088336
122Cerebral hypomyelination (HP:0006808)1.74732316
123Bowel incontinence (HP:0002607)1.74628932
124Tetraplegia (HP:0002445)1.73852668
125Distal sensory impairment (HP:0002936)1.72350923
126Intellectual disability, profound (HP:0002187)1.71634849
127Abnormality of saccadic eye movements (HP:0000570)1.71530125
128Pheochromocytoma (HP:0002666)1.71468158
129Foot dorsiflexor weakness (HP:0009027)1.71242550
130Hammertoe (HP:0001765)1.71198524
131Amyotrophic lateral sclerosis (HP:0007354)1.70334648
132Ankyloglossia (HP:0010296)1.70126147
133Increased nuchal translucency (HP:0010880)1.68382629
134Distal lower limb amyotrophy (HP:0008944)1.67931772
135Precocious puberty (HP:0000826)1.67854779
136Abnormality of the diencephalon (HP:0010662)1.65288691

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.72360821
2NTRK34.18908038
3MAP3K93.85894933
4PRKD33.07302563
5DAPK22.99942870
6MARK12.98145349
7MINK12.62114692
8KSR22.52150811
9PAK62.51701552
10MAP3K42.50344402
11CAMKK12.06866013
12NTRK22.05532267
13MAP2K71.88868276
14NTRK11.87604361
15SMG11.84165041
16MAP2K41.76788830
17KSR11.65817038
18PRPF4B1.61013111
19CDK51.56425635
20STK381.52384531
21EEF2K1.49225540
22DAPK11.47630222
23MAP3K131.43822141
24IRAK31.40264417
25SIK11.40071224
26TNIK1.38128758
27TYRO31.36053029
28CDK121.33989743
29MAP3K21.32000259
30ARAF1.31482073
31PHKG21.29220581
32PHKG11.29220581
33FGFR41.23274810
34SIK21.21746351
35PRKCG1.20206288
36RIPK41.18956755
37LMTK21.18914418
38TAOK11.17067146
39FES1.09219739
40LATS21.04873910
41CAMK11.03674542
42UHMK11.02641868
43MAPK131.02640692
44PRKCH1.02048321
45GRK51.01953500
46MAP3K121.00971297
47PAK30.99350590
48MAP3K110.97632839
49SGK4940.97257137
50SGK2230.97257137
51PTK2B0.95253956
52MAP3K70.94449158
53IRAK20.93995224
54PLK20.93258364
55CDK190.93099849
56RET0.93005262
57PKN20.91420498
58PINK10.87341389
59RIPK10.87099241
60STK110.86789099
61RAF10.84211510
62CAMK2A0.83956435
63CDK150.83473395
64CDK180.82521282
65TAOK20.81302161
66ALK0.81146622
67TESK10.80763392
68BRAF0.80083922
69PDK10.79128901
70MARK20.77331821
71CDK140.76039711
72PDPK10.75861166
73SGK30.75511075
74PTK20.75140640
75TRIB30.73689155
76CAMK2B0.72510067
77CDK11A0.71181796
78MAP3K10.69416294
79CAMK1D0.67862264
80PRKCZ0.66277517
81SGK20.66136324
82DDR20.65191840
83SGK10.62433989
84DYRK1A0.62253986
85CSNK1G20.61274903
86PRKG20.60687292
87MTOR0.57298419
88LIMK10.56658078
89CAMK40.56284189
90ERN10.55079649
91FER0.54244967
92OXSR10.51415835
93DAPK30.51306474
94NEK10.51254819
95RPS6KA30.50959086
96FGFR20.50238674
97EPHA20.49598728
98MAP2K10.49115412
99CAMKK20.48479875
100FYN0.48236580
101CAMK1G0.48021605
102ROCK20.46549397
103PRKD20.46164107
104PTK60.45592594
105CAMK2G0.45329024
106CDC42BPA0.45100781
107CASK0.44389199
108DYRK1B0.44312857
109ERBB20.42606848
110PDGFRA0.42354656
111TNK20.42029034
112DMPK0.41271150
113ICK0.40565986
114MAPK100.40112417
115FGFR30.39238476
116BRSK10.39052306
117PKN10.36995263
118RPS6KA20.36763504
119PNCK0.36313299
120CAMK2D0.36273285
121BMX0.35186151
122PRKCE0.34714535
123NEK60.34609482
124MAPK80.33907077
125MAPK120.33834603
126MAP3K100.33236612
127FGR0.32542169

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.33110944
2Nicotine addiction_Homo sapiens_hsa050332.88620839
3Synaptic vesicle cycle_Homo sapiens_hsa047212.81252921
4Olfactory transduction_Homo sapiens_hsa047402.67156499
5Circadian entrainment_Homo sapiens_hsa047132.45992076
6GABAergic synapse_Homo sapiens_hsa047272.39930105
7Long-term potentiation_Homo sapiens_hsa047202.34306552
8Glutamatergic synapse_Homo sapiens_hsa047242.33910286
9Vitamin B6 metabolism_Homo sapiens_hsa007502.27554402
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.17871641
11Amphetamine addiction_Homo sapiens_hsa050312.14984648
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.11326989
13Morphine addiction_Homo sapiens_hsa050322.07005983
14Salivary secretion_Homo sapiens_hsa049701.95548823
15Insulin secretion_Homo sapiens_hsa049111.93580511
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.85750469
17Dopaminergic synapse_Homo sapiens_hsa047281.82378085
18Gastric acid secretion_Homo sapiens_hsa049711.81791822
19Cholinergic synapse_Homo sapiens_hsa047251.72476784
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.61873450
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56453830
22Oxytocin signaling pathway_Homo sapiens_hsa049211.45086027
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.43311127
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42407728
25Cocaine addiction_Homo sapiens_hsa050301.35920129
26Calcium signaling pathway_Homo sapiens_hsa040201.35055395
27GnRH signaling pathway_Homo sapiens_hsa049121.34566837
28Arginine biosynthesis_Homo sapiens_hsa002201.34459137
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31024297
30Renin secretion_Homo sapiens_hsa049241.30489937
31Long-term depression_Homo sapiens_hsa047301.23330484
32Bile secretion_Homo sapiens_hsa049761.23276614
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.21295912
34Glioma_Homo sapiens_hsa052141.19532171
35Type II diabetes mellitus_Homo sapiens_hsa049301.16581222
36Taste transduction_Homo sapiens_hsa047421.16223090
37cAMP signaling pathway_Homo sapiens_hsa040241.13205308
38Gap junction_Homo sapiens_hsa045401.12751099
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11374987
40Serotonergic synapse_Homo sapiens_hsa047261.08810742
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08623273
42Estrogen signaling pathway_Homo sapiens_hsa049151.02872086
43Axon guidance_Homo sapiens_hsa043601.01980109
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01637593
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99933950
46Central carbon metabolism in cancer_Homo sapiens_hsa052300.98109837
47Melanogenesis_Homo sapiens_hsa049160.96484290
48ErbB signaling pathway_Homo sapiens_hsa040120.96179409
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94668919
50Chronic myeloid leukemia_Homo sapiens_hsa052200.88369230
51cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86416087
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84920284
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.82803275
54Notch signaling pathway_Homo sapiens_hsa043300.81398082
55Butanoate metabolism_Homo sapiens_hsa006500.80962872
56Thyroid hormone synthesis_Homo sapiens_hsa049180.78772023
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.77375232
58Wnt signaling pathway_Homo sapiens_hsa043100.77171624
59Hippo signaling pathway_Homo sapiens_hsa043900.75707010
60Dorso-ventral axis formation_Homo sapiens_hsa043200.75472194
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.73422092
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71001744
63Prion diseases_Homo sapiens_hsa050200.68616300
64Glucagon signaling pathway_Homo sapiens_hsa049220.68584413
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68290618
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68230930
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67813995
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67669327
69Pancreatic secretion_Homo sapiens_hsa049720.67598119
70Collecting duct acid secretion_Homo sapiens_hsa049660.67287105
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67278809
72AMPK signaling pathway_Homo sapiens_hsa041520.66826666
73Choline metabolism in cancer_Homo sapiens_hsa052310.65358405
74Fatty acid biosynthesis_Homo sapiens_hsa000610.61348167
75VEGF signaling pathway_Homo sapiens_hsa043700.59672133
76Colorectal cancer_Homo sapiens_hsa052100.59618393
77Biosynthesis of amino acids_Homo sapiens_hsa012300.59008844
78Arginine and proline metabolism_Homo sapiens_hsa003300.58135311
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.56678865
80Dilated cardiomyopathy_Homo sapiens_hsa054140.56597127
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56445687
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56088848
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54475008
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54318256
85Oocyte meiosis_Homo sapiens_hsa041140.53641217
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51845537
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49826773
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48603843
89Cardiac muscle contraction_Homo sapiens_hsa042600.48554738
90MAPK signaling pathway_Homo sapiens_hsa040100.47868194
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47731910
92Rap1 signaling pathway_Homo sapiens_hsa040150.47365538
93Endocytosis_Homo sapiens_hsa041440.47247402
94Focal adhesion_Homo sapiens_hsa045100.46995117
95Basal cell carcinoma_Homo sapiens_hsa052170.46761967
96Bladder cancer_Homo sapiens_hsa052190.46406043
97Proteoglycans in cancer_Homo sapiens_hsa052050.45926268
98Pancreatic cancer_Homo sapiens_hsa052120.45501399
99mTOR signaling pathway_Homo sapiens_hsa041500.45469718
100HIF-1 signaling pathway_Homo sapiens_hsa040660.44174744
101Insulin signaling pathway_Homo sapiens_hsa049100.43962122
102Ras signaling pathway_Homo sapiens_hsa040140.43588329
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.43499230
104Tight junction_Homo sapiens_hsa045300.42319893
105Endometrial cancer_Homo sapiens_hsa052130.42239738
106Thyroid cancer_Homo sapiens_hsa052160.41964641
107Non-small cell lung cancer_Homo sapiens_hsa052230.41803116
108Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40199176
109Vibrio cholerae infection_Homo sapiens_hsa051100.40140882
110PPAR signaling pathway_Homo sapiens_hsa033200.39031552
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38838447
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36687077
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35879131
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35829258
115Fatty acid metabolism_Homo sapiens_hsa012120.33458498
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33413221
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.32791526
118Ovarian steroidogenesis_Homo sapiens_hsa049130.31673486
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30843496
120Inositol phosphate metabolism_Homo sapiens_hsa005620.30705558
121Renal cell carcinoma_Homo sapiens_hsa052110.28147974
122Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28119649
123Circadian rhythm_Homo sapiens_hsa047100.27789147
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.27439848
125Glycerolipid metabolism_Homo sapiens_hsa005610.27119697

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