NSRP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sarcomere organization (GO:0060297)5.33460868
2kinetochore organization (GO:0051383)4.72906619
3behavioral response to nicotine (GO:0035095)4.72839652
4ribonucleoprotein complex disassembly (GO:0032988)4.54257325
5plasma membrane repair (GO:0001778)4.51101820
6organelle disassembly (GO:1903008)4.50186296
7kinetochore assembly (GO:0051382)4.43796583
8maturation of SSU-rRNA (GO:0030490)4.39234971
9ribosomal small subunit biogenesis (GO:0042274)4.28728366
10regulation of action potential (GO:0098900)4.28461596
11attachment of spindle microtubules to kinetochore (GO:0008608)4.27817554
12regulation of skeletal muscle contraction (GO:0014819)4.20198372
13negative regulation of protein localization to cell surface (GO:2000009)4.12970551
14protein complex biogenesis (GO:0070271)4.02882419
15negative regulation of nitric-oxide synthase activity (GO:0051001)3.99219996
16CENP-A containing nucleosome assembly (GO:0034080)3.96127909
17protein neddylation (GO:0045116)3.91139659
18proteasome assembly (GO:0043248)3.89241826
19chromatin remodeling at centromere (GO:0031055)3.82359294
20ubiquinone metabolic process (GO:0006743)3.79551196
21mitochondrial respiratory chain complex assembly (GO:0033108)3.79273445
22meiotic chromosome segregation (GO:0045132)3.66033103
23DNA replication checkpoint (GO:0000076)3.62874316
24ribosomal small subunit assembly (GO:0000028)3.59704473
25mitotic metaphase plate congression (GO:0007080)3.59572448
26viral transcription (GO:0019083)3.54386387
27DNA ligation (GO:0006266)3.52418275
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.52146129
29piRNA metabolic process (GO:0034587)3.50481922
30DNA deamination (GO:0045006)3.48270730
31translational termination (GO:0006415)3.46898191
32negative regulation of organelle assembly (GO:1902116)3.44466285
33postreplication repair (GO:0006301)3.41760514
34DNA replication-independent nucleosome organization (GO:0034724)3.36162210
35DNA replication-independent nucleosome assembly (GO:0006336)3.36162210
36establishment of integrated proviral latency (GO:0075713)3.34667919
37water-soluble vitamin biosynthetic process (GO:0042364)3.34277988
38ribosomal large subunit biogenesis (GO:0042273)3.34216716
39negative regulation of muscle hypertrophy (GO:0014741)3.31880752
40kidney morphogenesis (GO:0060993)3.28933408
41termination of RNA polymerase III transcription (GO:0006386)3.27155045
42transcription elongation from RNA polymerase III promoter (GO:0006385)3.27155045
43metaphase plate congression (GO:0051310)3.27019233
44cotranslational protein targeting to membrane (GO:0006613)3.21130856
45RNA capping (GO:0036260)3.19415764
467-methylguanosine RNA capping (GO:0009452)3.19415764
47histone exchange (GO:0043486)3.19191737
48negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.19191346
49DNA methylation involved in gamete generation (GO:0043046)3.17839894
50SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.17839484
51transcription elongation from RNA polymerase I promoter (GO:0006362)3.13807427
527-methylguanosine mRNA capping (GO:0006370)3.13601385
53protein targeting to ER (GO:0045047)3.13436533
54negative regulation of DNA-dependent DNA replication (GO:2000104)3.12875027
55maturation of 5.8S rRNA (GO:0000460)3.11883699
56nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.08831152
57cytochrome complex assembly (GO:0017004)3.08588687
58neuron remodeling (GO:0016322)3.07865268
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.07836775
60regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.07218461
61regulation of mitotic spindle checkpoint (GO:1903504)3.07218461
62protein-cofactor linkage (GO:0018065)3.06297189
63cullin deneddylation (GO:0010388)3.05491146
64kynurenine metabolic process (GO:0070189)3.03811842
65positive regulation of microtubule polymerization (GO:0031116)3.03461304
66regulation of pigment cell differentiation (GO:0050932)3.00854037
67protein deneddylation (GO:0000338)2.97163878
68positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.96079446
69establishment of protein localization to endoplasmic reticulum (GO:0072599)2.96068698
70protein localization to endoplasmic reticulum (GO:0070972)2.95768696
71spinal cord motor neuron differentiation (GO:0021522)2.95721330
72termination of RNA polymerase I transcription (GO:0006363)2.94927514
73establishment of viral latency (GO:0019043)2.94094102
74mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.94017946
75rRNA processing (GO:0006364)2.91090422
76cellular ketone body metabolic process (GO:0046950)2.90170940
77translational initiation (GO:0006413)2.89528184
78electron transport chain (GO:0022900)2.89198642
79L-fucose metabolic process (GO:0042354)2.88224215
80L-fucose catabolic process (GO:0042355)2.88224215
81fucose catabolic process (GO:0019317)2.88224215
82establishment of chromosome localization (GO:0051303)2.87292614
83GTP biosynthetic process (GO:0006183)2.85648235
84nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.85391734
85negative regulation of cardiac muscle tissue growth (GO:0055022)2.85192233
86negative regulation of heart growth (GO:0061117)2.85192233
87spliceosomal complex assembly (GO:0000245)2.84930444
88ribonucleoprotein complex biogenesis (GO:0022613)2.84322379
89respiratory electron transport chain (GO:0022904)2.82551483
90endosome to pigment granule transport (GO:0043485)2.80839083
91endosome to melanosome transport (GO:0035646)2.80839083
92tryptophan catabolic process (GO:0006569)2.79477666
93indole-containing compound catabolic process (GO:0042436)2.79477666
94indolalkylamine catabolic process (GO:0046218)2.79477666
95telomere maintenance via recombination (GO:0000722)2.79447971
96rRNA metabolic process (GO:0016072)2.79331297
97RNA-dependent DNA replication (GO:0006278)2.79315833
98regulation of membrane repolarization (GO:0060306)2.79097616
99telomere maintenance via telomerase (GO:0007004)2.77988404
100negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.77457355
101negative regulation of potassium ion transmembrane transport (GO:1901380)2.77103628
102negative regulation of cardiac muscle hypertrophy (GO:0010614)2.76255727
103cellular protein complex disassembly (GO:0043624)2.75669926
104transcription elongation from RNA polymerase II promoter (GO:0006368)2.75548867
105indolalkylamine metabolic process (GO:0006586)2.74975198
106mitochondrial respiratory chain complex I assembly (GO:0032981)2.73766884
107NADH dehydrogenase complex assembly (GO:0010257)2.73766884
108mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.73766884
109telomere maintenance via semi-conservative replication (GO:0032201)2.73235296
110peptidyl-histidine modification (GO:0018202)2.72122983
111ATP synthesis coupled proton transport (GO:0015986)2.71618992
112energy coupled proton transport, down electrochemical gradient (GO:0015985)2.71618992
113translational elongation (GO:0006414)2.70896671
114anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.70668482
115viral life cycle (GO:0019058)2.70116253
116maternal behavior (GO:0042711)2.69997992
117DNA replication initiation (GO:0006270)2.69923748
118transcription-coupled nucleotide-excision repair (GO:0006283)2.69083981
119detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.68831745
120platelet dense granule organization (GO:0060155)2.68676038
121intestinal epithelial cell development (GO:0060576)2.67882957
122positive regulation of skeletal muscle tissue development (GO:0048643)2.67294384
123microtubule depolymerization (GO:0007019)2.66736485
124positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.66116726
125DNA-templated transcription, elongation (GO:0006354)2.66039940
126transcription from RNA polymerase I promoter (GO:0006360)2.65597205
127negative regulation of telomere maintenance (GO:0032205)2.64950690
128parental behavior (GO:0060746)2.64473825
129viral mRNA export from host cell nucleus (GO:0046784)2.64359347
130centriole replication (GO:0007099)2.63325811
131regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.62243512
132DNA strand elongation involved in DNA replication (GO:0006271)2.61257990
133mitotic recombination (GO:0006312)2.61242666
134ketone body metabolic process (GO:1902224)2.60825272
135translation (GO:0006412)2.60587081
136spindle checkpoint (GO:0031577)2.60022619
137respiratory chain complex IV assembly (GO:0008535)2.59816348
138regulation of hippo signaling (GO:0035330)2.58961212
139histone mRNA metabolic process (GO:0008334)2.58911629
140positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.58739934
141telomere maintenance via telomere lengthening (GO:0010833)2.58186921
142lens fiber cell differentiation (GO:0070306)2.55992132
143negative regulation of T cell differentiation in thymus (GO:0033085)2.55876461
144negative regulation of ligase activity (GO:0051352)2.55667578
145negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.55667578
146epithelial cilium movement (GO:0003351)2.55386728
147chaperone-mediated protein transport (GO:0072321)2.54817896
148spliceosomal snRNP assembly (GO:0000387)2.53950278
149recombinational repair (GO:0000725)2.53663156
150regulation of glucokinase activity (GO:0033131)2.52771284
151regulation of hexokinase activity (GO:1903299)2.52771284
152double-strand break repair via homologous recombination (GO:0000724)2.52559946
153behavioral response to ethanol (GO:0048149)2.52342944
154negative regulation of transcription regulatory region DNA binding (GO:2000678)2.52247044
155regulation of nuclear cell cycle DNA replication (GO:0033262)2.51359202
156cellular component biogenesis (GO:0044085)2.50379164
157DNA strand elongation (GO:0022616)2.49824546
158nonmotile primary cilium assembly (GO:0035058)2.49578532
159replication fork processing (GO:0031297)2.49200067
160regulation of double-strand break repair via homologous recombination (GO:0010569)2.48602935
161cell fate commitment involved in formation of primary germ layer (GO:0060795)2.48443150
162detection of light stimulus involved in sensory perception (GO:0050962)2.48426514
163detection of light stimulus involved in visual perception (GO:0050908)2.48426514
164mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.48269882
165positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.47748541
166regulation of mesoderm development (GO:2000380)2.47487178
167maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.47340065
168deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.46551473
169establishment of protein localization to mitochondrial membrane (GO:0090151)2.46472939
170spindle assembly checkpoint (GO:0071173)2.45875241
171pseudouridine synthesis (GO:0001522)2.45560287
172intracellular protein transmembrane import (GO:0044743)2.44551142
173preassembly of GPI anchor in ER membrane (GO:0016254)2.43477073
174reciprocal DNA recombination (GO:0035825)2.43347939
175reciprocal meiotic recombination (GO:0007131)2.43347939
176oxidative demethylation (GO:0070989)2.43028793
177Sertoli cell development (GO:0060009)2.41609790
178protein K6-linked ubiquitination (GO:0085020)2.38600196
179negative regulation of cardiac muscle tissue development (GO:0055026)2.37711804
180hydrogen ion transmembrane transport (GO:1902600)2.35449073

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.63239640
2ZNF274_21170338_ChIP-Seq_K562_Hela4.30588013
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.02652658
4E2F7_22180533_ChIP-Seq_HELA_Human4.02475160
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.62267380
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.55281321
7EZH2_22144423_ChIP-Seq_EOC_Human3.13930586
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.00249436
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.98276851
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.92331576
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.91630596
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.91377441
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.83078613
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.72537742
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.62082762
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.59837401
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.56580988
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.54086421
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.52051992
20GBX2_23144817_ChIP-Seq_PC3_Human2.45504821
21ELK1_19687146_ChIP-ChIP_HELA_Human2.45293203
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.31296060
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.29329481
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.28856443
25VDR_23849224_ChIP-Seq_CD4+_Human2.18237618
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.16199711
27FUS_26573619_Chip-Seq_HEK293_Human2.08741842
28CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03956669
29TP63_19390658_ChIP-ChIP_HaCaT_Human2.03656716
30ELF1_17652178_ChIP-ChIP_JURKAT_Human2.00966906
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.98959309
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98914939
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.95707386
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94736267
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.83633396
36P300_19829295_ChIP-Seq_ESCs_Human1.81727658
37TTF2_22483619_ChIP-Seq_HELA_Human1.79691251
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79044056
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75903130
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.74793558
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74008046
42DCP1A_22483619_ChIP-Seq_HELA_Human1.70367101
43FOXP3_21729870_ChIP-Seq_TREG_Human1.70353489
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.68670694
45MYC_18358816_ChIP-ChIP_MESCs_Mouse1.67877823
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66958450
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.65774729
48BCAT_22108803_ChIP-Seq_LS180_Human1.65510698
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.65177887
50XRN2_22483619_ChIP-Seq_HELA_Human1.59346388
51NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.58995194
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58809103
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58243531
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58187491
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58054822
56TAF15_26573619_Chip-Seq_HEK293_Human1.57302635
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54767549
58IRF1_19129219_ChIP-ChIP_H3396_Human1.53790305
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53359252
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.53182127
61EWS_26573619_Chip-Seq_HEK293_Human1.52953977
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51458956
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50625131
64VDR_22108803_ChIP-Seq_LS180_Human1.50062085
65E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48897300
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47756750
67CBP_20019798_ChIP-Seq_JUKART_Human1.47745949
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47745949
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47484234
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.47484234
71TP53_22573176_ChIP-Seq_HFKS_Human1.46735563
72MYC_18940864_ChIP-ChIP_HL60_Human1.43973378
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43508864
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40945722
75NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39760669
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37461777
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.36625622
78KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36459816
79STAT3_23295773_ChIP-Seq_U87_Human1.36385418
80ELK1_22589737_ChIP-Seq_MCF10A_Human1.35744495
81AR_21909140_ChIP-Seq_LNCAP_Human1.35636599
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.35151592
83IGF1R_20145208_ChIP-Seq_DFB_Human1.34347231
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31301773
85YY1_21170310_ChIP-Seq_MESCs_Mouse1.31291368
86SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31047925
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30466628
88FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27420292
89FOXA1_25329375_ChIP-Seq_VCAP_Human1.27420292
90TCF4_23295773_ChIP-Seq_U87_Human1.26162688
91AR_25329375_ChIP-Seq_VCAP_Human1.25372138
92RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25136093
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24365020
94THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24053824
95NANOG_19829295_ChIP-Seq_ESCs_Human1.24034109
96SOX2_19829295_ChIP-Seq_ESCs_Human1.24034109
97SMAD4_21799915_ChIP-Seq_A2780_Human1.21744903
98RNF2_27304074_Chip-Seq_NSC_Mouse1.20779149
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18622410
100PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18284269
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17976273
102PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17830507
103KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17351721
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17073288
105MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16068048
106NOTCH1_21737748_ChIP-Seq_TLL_Human1.15462939
107PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14568941
108SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13464838
109ER_23166858_ChIP-Seq_MCF-7_Human1.13099171
110NCOR_22424771_ChIP-Seq_293T_Human1.12591349
111NFE2_27457419_Chip-Seq_LIVER_Mouse1.11821504
112SMAD4_21741376_ChIP-Seq_EPCs_Human1.11676562
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11586878
114GABP_19822575_ChIP-Seq_HepG2_Human1.11279705
115SMAD3_21741376_ChIP-Seq_EPCs_Human1.10413737
116E2F1_21310950_ChIP-Seq_MCF-7_Human1.09860890
117ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09846913
118SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09524448
119TCF4_22108803_ChIP-Seq_LS180_Human1.07856385
120GATA3_21878914_ChIP-Seq_MCF-7_Human1.06499548
121KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06159077
122KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06159077
123KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06159077
124JUN_21703547_ChIP-Seq_K562_Human1.06063479
125AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05988548
126FLI1_21867929_ChIP-Seq_TH2_Mouse1.05537845
127TDRD3_21172665_ChIP-Seq_MCF-7_Human1.03626624
128IRF8_21731497_ChIP-ChIP_J774_Mouse1.02873415
129EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01995551
130IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00924551
131FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99820540
132OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99447500
133PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98339760
134ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98269684
135SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98152879
136P53_22387025_ChIP-Seq_ESCs_Mouse0.96669292
137POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95290843
138REST_21632747_ChIP-Seq_MESCs_Mouse0.95070553
139TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94135508
140HOXB7_26014856_ChIP-Seq_BT474_Human0.94031495
141FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93738925
142POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93679542
143CBX2_27304074_Chip-Seq_ESCs_Mouse0.93582849
144EZH2_27294783_Chip-Seq_NPCs_Mouse0.93297938
145AR_20517297_ChIP-Seq_VCAP_Human0.93078886
146CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92561087
147CDX2_22108803_ChIP-Seq_LS180_Human0.92263414
148SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91861661
149TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91684799
150FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.90877757
151EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.90566764
152EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90075874
153NANOG_18555785_Chip-Seq_ESCs_Mouse0.88796402
154NANOG_18555785_ChIP-Seq_MESCs_Mouse0.88006723
155EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87766736
156KAP1_22055183_ChIP-Seq_ESCs_Mouse0.87380092
157STAT3_18555785_Chip-Seq_ESCs_Mouse0.86661038
158CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.84532862
159FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84517144
160SPI1_23547873_ChIP-Seq_NB4_Human0.84431009
161E2F1_18555785_Chip-Seq_ESCs_Mouse0.84367264

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.78658174
2MP0008057_abnormal_DNA_replication3.63037005
3MP0003136_yellow_coat_color3.22844346
4MP0003693_abnormal_embryo_hatching2.98234949
5MP0008058_abnormal_DNA_repair2.90343418
6MP0006292_abnormal_olfactory_placode2.86445924
7MP0010094_abnormal_chromosome_stability2.86196615
8MP0002837_dystrophic_cardiac_calcinosis2.57903555
9MP0003195_calcinosis2.48271950
10MP0000569_abnormal_digit_pigmentation2.47360832
11MP0003077_abnormal_cell_cycle2.41785271
12MP0003718_maternal_effect2.41347804
13MP0004957_abnormal_blastocyst_morpholog2.40880071
14MP0009379_abnormal_foot_pigmentation2.29921757
15MP0005187_abnormal_penis_morphology2.26961927
16MP0003111_abnormal_nucleus_morphology2.15049649
17MP0008932_abnormal_embryonic_tissue2.03524364
18MP0003787_abnormal_imprinting2.03080115
19MP0001188_hyperpigmentation2.00665684
20MP0001968_abnormal_touch/_nociception1.98134200
21MP0002163_abnormal_gland_morphology1.89505965
22MP0005409_darkened_coat_color1.88954173
23MP0008007_abnormal_cellular_replicative1.86116714
24MP0003283_abnormal_digestive_organ1.81080554
25MP0002277_abnormal_respiratory_mucosa1.81013775
26MP0001529_abnormal_vocalization1.79200419
27MP0005171_absent_coat_pigmentation1.77404226
28MP0008872_abnormal_physiological_respon1.72575403
29MP0002736_abnormal_nociception_after1.69313042
30MP0003123_paternal_imprinting1.65839712
31MP0009046_muscle_twitch1.65144715
32MP0003121_genomic_imprinting1.63099293
33MP0003786_premature_aging1.63048951
34MP0000647_abnormal_sebaceous_gland1.60986529
35MP0004885_abnormal_endolymph1.57010645
36MP0009697_abnormal_copulation1.52981007
37MP0002210_abnormal_sex_determination1.48159306
38MP0001986_abnormal_taste_sensitivity1.48028166
39MP0005551_abnormal_eye_electrophysiolog1.46393661
40MP0002102_abnormal_ear_morphology1.45553492
41MP0003011_delayed_dark_adaptation1.43920322
42MP0004145_abnormal_muscle_electrophysio1.43360708
43MP0004133_heterotaxia1.40162969
44MP0002938_white_spotting1.39683839
45MP0004043_abnormal_pH_regulation1.38631287
46MP0002638_abnormal_pupillary_reflex1.38488630
47MP0004381_abnormal_hair_follicle1.37461242
48MP0000566_synostosis1.36704247
49MP0000383_abnormal_hair_follicle1.36271588
50MP0001905_abnormal_dopamine_level1.34851078
51MP0000015_abnormal_ear_pigmentation1.33248081
52MP0003646_muscle_fatigue1.32214333
53MP0003950_abnormal_plasma_membrane1.31493683
54MP0009745_abnormal_behavioral_response1.31425272
55MP0002272_abnormal_nervous_system1.30773644
56MP0008995_early_reproductive_senescence1.29179700
57MP0001293_anophthalmia1.27469192
58MP0003938_abnormal_ear_development1.24887595
59MP0002396_abnormal_hematopoietic_system1.24300835
60MP0005379_endocrine/exocrine_gland_phen1.24226212
61MP0000749_muscle_degeneration1.23984914
62MP0001486_abnormal_startle_reflex1.22539776
63MP0003937_abnormal_limbs/digits/tail_de1.22413762
64MP0005671_abnormal_response_to1.21458272
65MP0003315_abnormal_perineum_morphology1.20465288
66MP0005645_abnormal_hypothalamus_physiol1.20065316
67MP0003806_abnormal_nucleotide_metabolis1.19929622
68MP0005408_hypopigmentation1.19872172
69MP0001929_abnormal_gametogenesis1.18967335
70MP0000427_abnormal_hair_cycle1.18191865
71MP0002148_abnormal_hypersensitivity_rea1.17012697
72MP0002234_abnormal_pharynx_morphology1.16782592
73MP0000653_abnormal_sex_gland1.16714540
74MP0003941_abnormal_skin_development1.16559277
75MP0001346_abnormal_lacrimal_gland1.15979174
76MP0001835_abnormal_antigen_presentation1.15887042
77MP0002876_abnormal_thyroid_physiology1.15227891
78MP0004147_increased_porphyrin_level1.14890886
79MP0005075_abnormal_melanosome_morpholog1.14646902
80MP0005174_abnormal_tail_pigmentation1.14203033
81MP0004142_abnormal_muscle_tone1.13666825
82MP0008875_abnormal_xenobiotic_pharmacok1.13047838
83MP0001145_abnormal_male_reproductive1.11912131
84MP0008789_abnormal_olfactory_epithelium1.11214730
85MP0001119_abnormal_female_reproductive1.09315959
86MP0009333_abnormal_splenocyte_physiolog1.09046927
87MP0005253_abnormal_eye_physiology1.08937479
88MP0002928_abnormal_bile_duct1.08701085
89MP0000631_abnormal_neuroendocrine_gland1.06885327
90MP0009785_altered_susceptibility_to1.04721775
91MP0003252_abnormal_bile_duct1.04525804
92MP0000350_abnormal_cell_proliferation1.02629121
93MP0000372_irregular_coat_pigmentation1.01819315
94MP0005646_abnormal_pituitary_gland1.01689175
95MP0008260_abnormal_autophagy1.00160795
96MP0002734_abnormal_mechanical_nocicepti0.98496597
97MP0002751_abnormal_autonomic_nervous0.95728966
98MP0000049_abnormal_middle_ear0.95154832
99MP0001727_abnormal_embryo_implantation0.94517575
100MP0004742_abnormal_vestibular_system0.94439801
101MP0005389_reproductive_system_phenotype0.94366029
102MP0009250_abnormal_appendicular_skeleto0.93522882
103MP0002160_abnormal_reproductive_system0.92738192
104MP0002735_abnormal_chemical_nociception0.92478887
105MP0002653_abnormal_ependyma_morphology0.92333455
106MP0002095_abnormal_skin_pigmentation0.91884933
107MP0003880_abnormal_central_pattern0.90653456
108MP0003724_increased_susceptibility_to0.90337330
109MP0004215_abnormal_myocardial_fiber0.90328219
110MP0005386_behavior/neurological_phenoty0.89009187
111MP0004924_abnormal_behavior0.89009187
112MP0002557_abnormal_social/conspecific_i0.88810406
113MP0002067_abnormal_sensory_capabilities0.88773805
114MP0001919_abnormal_reproductive_system0.88770810
115MP0000490_abnormal_crypts_of0.87677169
116MP0005084_abnormal_gallbladder_morpholo0.86218322
117MP0002177_abnormal_outer_ear0.84993602
118MP0005000_abnormal_immune_tolerance0.83778258
119MP0000313_abnormal_cell_death0.83565502
120MP0002282_abnormal_trachea_morphology0.83559228
121MP0003122_maternal_imprinting0.83342527
122MP0001501_abnormal_sleep_pattern0.83223898
123MP0003890_abnormal_embryonic-extraembry0.82880171
124MP0002138_abnormal_hepatobiliary_system0.81776650
125MP0005451_abnormal_body_composition0.80050601
126MP0002452_abnormal_antigen_presenting0.78869267
127MP0003763_abnormal_thymus_physiology0.78651289
128MP0002184_abnormal_innervation0.78030331
129MP0001485_abnormal_pinna_reflex0.77632720
130MP0001286_abnormal_eye_development0.77271072
131MP0002733_abnormal_thermal_nociception0.76327253
132MP0003119_abnormal_digestive_system0.75951823
133MP0000026_abnormal_inner_ear0.75506960
134MP0002723_abnormal_immune_serum0.74813107
135MP0005195_abnormal_posterior_eye0.73220746
136MP0003186_abnormal_redox_activity0.73177076
137MP0002420_abnormal_adaptive_immunity0.72076090
138MP0003698_abnormal_male_reproductive0.71892509
139MP0001800_abnormal_humoral_immune0.71545264
140MP0000230_abnormal_systemic_arterial0.71372543
141MP0001819_abnormal_immune_cell0.71122882
142MP0001730_embryonic_growth_arrest0.70940443
143MP0001324_abnormal_eye_pigmentation0.70275609
144MP0002572_abnormal_emotion/affect_behav0.70155995
145MP0010030_abnormal_orbit_morphology0.69282641
146MP0001853_heart_inflammation0.68484663
147MP0003755_abnormal_palate_morphology0.68260981
148MP0002752_abnormal_somatic_nervous0.67771803
149MP0002398_abnormal_bone_marrow0.67672029
150MP0006072_abnormal_retinal_apoptosis0.67221326
151MP0002085_abnormal_embryonic_tissue0.67197181
152MP0005025_abnormal_response_to0.66132669
153MP0001970_abnormal_pain_threshold0.66085899
154MP0005395_other_phenotype0.65984597
155MP0002419_abnormal_innate_immunity0.63828017
156MP0006276_abnormal_autonomic_nervous0.63683625
157MP0003385_abnormal_body_wall0.62890171
158MP0000703_abnormal_thymus_morphology0.62302727
159MP0000716_abnormal_immune_system0.61963763

Predicted human phenotypes

RankGene SetZ-score
1Calf muscle hypertrophy (HP:0008981)4.10793084
2Molar tooth sign on MRI (HP:0002419)3.86881494
3Abnormality of midbrain morphology (HP:0002418)3.86881494
4Renal cortical cysts (HP:0000803)3.78981250
5Abnormality of the renal cortex (HP:0011035)3.78822263
6Muscle hypertrophy of the lower extremities (HP:0008968)3.62158749
7Chromsome breakage (HP:0040012)3.59158595
8Birth length less than 3rd percentile (HP:0003561)3.46148583
9Increased hepatocellular lipid droplets (HP:0006565)3.28339240
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.24085916
11Nephronophthisis (HP:0000090)3.23198829
12Patellar aplasia (HP:0006443)3.07033028
13Reticulocytopenia (HP:0001896)3.05593153
14Abnormal biliary tract physiology (HP:0012439)2.97725752
15Bile duct proliferation (HP:0001408)2.97725752
16Acute necrotizing encephalopathy (HP:0006965)2.96553709
17Congenital, generalized hypertrichosis (HP:0004540)2.92959782
18Aplasia/Hypoplasia of the patella (HP:0006498)2.88023547
19Abnormality of the renal medulla (HP:0100957)2.80163862
20Exertional dyspnea (HP:0002875)2.79715527
21Mitochondrial inheritance (HP:0001427)2.76808167
22Congenital stationary night blindness (HP:0007642)2.73705857
23Renal Fanconi syndrome (HP:0001994)2.70057051
24Cystic liver disease (HP:0006706)2.69519775
25Lipid accumulation in hepatocytes (HP:0006561)2.66731589
26Chronic hepatic failure (HP:0100626)2.64300546
27Absent radius (HP:0003974)2.64236133
28Abnormality of cells of the erythroid lineage (HP:0012130)2.60232578
29Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.59367535
30Tubular atrophy (HP:0000092)2.58399894
31Parakeratosis (HP:0001036)2.55339780
32Oligodactyly (hands) (HP:0001180)2.54320616
33Aplasia involving forearm bones (HP:0009822)2.53430984
34Absent forearm bone (HP:0003953)2.53430984
35Progressive macrocephaly (HP:0004481)2.51705790
36Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.50333442
37Supernumerary spleens (HP:0009799)2.49328283
38Abnormal drinking behavior (HP:0030082)2.48791323
39Polydipsia (HP:0001959)2.48791323
40Sclerocornea (HP:0000647)2.48226648
41Aplastic anemia (HP:0001915)2.44829740
42Type II lissencephaly (HP:0007260)2.44113832
43Hepatocellular necrosis (HP:0001404)2.41672553
44Abnormality of the preputium (HP:0100587)2.41534804
45Abnormal number of erythroid precursors (HP:0012131)2.40331354
46Macrocytic anemia (HP:0001972)2.39341594
47Cleft eyelid (HP:0000625)2.39160891
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.38466790
49Pendular nystagmus (HP:0012043)2.38032824
50Horseshoe kidney (HP:0000085)2.37856970
51Rib fusion (HP:0000902)2.36880168
52Concave nail (HP:0001598)2.36243681
53Increased corneal curvature (HP:0100692)2.35941890
54Keratoconus (HP:0000563)2.35941890
55Prolonged QT interval (HP:0001657)2.35833047
56Carpal bone hypoplasia (HP:0001498)2.33816945
57Triphalangeal thumb (HP:0001199)2.32363204
58Inability to walk (HP:0002540)2.30632364
59Congenital hepatic fibrosis (HP:0002612)2.30586954
60Abnormal mitochondria in muscle tissue (HP:0008316)2.28907265
61Nephroblastoma (Wilms tumor) (HP:0002667)2.25903810
62Large for gestational age (HP:0001520)2.25597076
63Increased CSF lactate (HP:0002490)2.22213267
64Metaphyseal dysplasia (HP:0100255)2.21228027
65Abnormality of chromosome stability (HP:0003220)2.20872359
66True hermaphroditism (HP:0010459)2.19998369
67Increased IgM level (HP:0003496)2.18906761
68Attenuation of retinal blood vessels (HP:0007843)2.17591608
69Abnormality of the columella (HP:0009929)2.16090709
70Hepatic necrosis (HP:0002605)2.15204237
71Meckel diverticulum (HP:0002245)2.14258335
72Abnormality of alanine metabolism (HP:0010916)2.13933365
73Hyperalaninemia (HP:0003348)2.13933365
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13933365
75Abolished electroretinogram (ERG) (HP:0000550)2.12873709
76Embryonal renal neoplasm (HP:0011794)2.12675926
77Medial flaring of the eyebrow (HP:0010747)2.11878894
78Aplasia/Hypoplasia of the tibia (HP:0005772)2.11668448
79Adrenal hypoplasia (HP:0000835)2.11567065
80Stenosis of the external auditory canal (HP:0000402)2.11197822
81Pancreatic fibrosis (HP:0100732)2.10500727
82Abnormal lung lobation (HP:0002101)2.10450224
83Aplasia/Hypoplasia of the tongue (HP:0010295)2.10047502
84Breast hypoplasia (HP:0003187)2.09802629
85Rough bone trabeculation (HP:0100670)2.08265316
86Abnormality of the ileum (HP:0001549)2.06568944
87Abnormal ciliary motility (HP:0012262)2.04867756
88Pancreatic cysts (HP:0001737)2.04666581
89Pallor (HP:0000980)2.04569447
90Myotonia (HP:0002486)2.04536715
91Furrowed tongue (HP:0000221)2.04015145
92Abnormality of the labia minora (HP:0012880)2.03175746
93Male pseudohermaphroditism (HP:0000037)2.02427307
94Hyperventilation (HP:0002883)2.01675638
95Oligodactyly (HP:0012165)2.01169840
96Subaortic stenosis (HP:0001682)2.00808458
97Abnormality of the left ventricular outflow tract (HP:0011103)2.00808458
98Aplasia/Hypoplasia of the sacrum (HP:0008517)1.99981104
99Exercise-induced muscle cramps (HP:0003710)1.98021050
100Optic nerve hypoplasia (HP:0000609)1.97241872
101Preaxial hand polydactyly (HP:0001177)1.96237490
102Type I transferrin isoform profile (HP:0003642)1.95820670
103Facial hemangioma (HP:0000329)1.94695269
104Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.94028241
105Absent thumb (HP:0009777)1.93842757
106Small hand (HP:0200055)1.93745165
107Methylmalonic acidemia (HP:0002912)1.93649608
108Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92825031
109Capillary hemangiomas (HP:0005306)1.92049806
110Abnormal respiratory motile cilium physiology (HP:0012261)1.91378390
111Abnormal rod and cone electroretinograms (HP:0008323)1.91214540
112Absent/shortened dynein arms (HP:0200106)1.90743530
113Dynein arm defect of respiratory motile cilia (HP:0012255)1.90743530
114Anencephaly (HP:0002323)1.90476484
115Acute encephalopathy (HP:0006846)1.90153153
116Absent rod-and cone-mediated responses on ERG (HP:0007688)1.90092578
117Septo-optic dysplasia (HP:0100842)1.89597464
118Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.89506665
119Hemiparesis (HP:0001269)1.89084813
120Myelodysplasia (HP:0002863)1.88499730
121Abnormality of the septum pellucidum (HP:0007375)1.88397450
122Abnormal trabecular bone morphology (HP:0100671)1.87356260
123Aplasia/Hypoplasia involving the musculature (HP:0001460)1.86636596
124Premature graying of hair (HP:0002216)1.86276641
125Respiratory difficulties (HP:0002880)1.86250928
126Intestinal atresia (HP:0011100)1.85952236
127Congenital primary aphakia (HP:0007707)1.85632066
128Aplasia cutis congenita (HP:0001057)1.85080826
129Optic disc pallor (HP:0000543)1.85036522
130Impulsivity (HP:0100710)1.83978788
131Gaze-evoked nystagmus (HP:0000640)1.83854769
132Abnormality of renal resorption (HP:0011038)1.83780280
133Polyuria (HP:0000103)1.82263511
134Aplasia/Hypoplasia of the uvula (HP:0010293)1.81468402
135Nephrogenic diabetes insipidus (HP:0009806)1.78788430
136Abnormal respiratory epithelium morphology (HP:0012253)1.78292253
137Abnormal respiratory motile cilium morphology (HP:0005938)1.78292253
138Abnormal hair whorl (HP:0010721)1.77914967
139Ectopic kidney (HP:0000086)1.77050147
140Oral leukoplakia (HP:0002745)1.76396073
141Small epiphyses (HP:0010585)1.75366086
142Hypoplasia of the capital femoral epiphysis (HP:0003090)1.75235036
143Duplicated collecting system (HP:0000081)1.74685633
144Small intestinal stenosis (HP:0012848)1.74676600
145Duodenal stenosis (HP:0100867)1.74676600
146Volvulus (HP:0002580)1.74531242
147Gait imbalance (HP:0002141)1.74504624
148Type 2 muscle fiber atrophy (HP:0003554)1.74446140
149Abnormality of the pons (HP:0007361)1.74414688
150Aplasia/hypoplasia of the uterus (HP:0008684)1.74027695
151Hypothermia (HP:0002045)1.73943490
152Aplasia of the musculature (HP:0100854)1.73141112
153Cerebral edema (HP:0002181)1.72929621
1543-Methylglutaconic aciduria (HP:0003535)1.71500391
155Tachypnea (HP:0002789)1.71451751
156Thyroiditis (HP:0100646)1.71218874
157Median cleft lip (HP:0000161)1.71069557
158Recurrent abscess formation (HP:0002722)1.71063714
159Hypoplasia of the pons (HP:0012110)1.70803783
160Abnormality of the renal collecting system (HP:0004742)1.70602420
161Abnormal EKG (HP:0003115)1.70419426
162Brushfield spots (HP:0001088)1.68235569
163Anophthalmia (HP:0000528)1.67908447
164Progressive inability to walk (HP:0002505)1.65592945
165Febrile seizures (HP:0002373)1.65489842
166Choroideremia (HP:0001139)1.65403035
167Poor suck (HP:0002033)1.64219339
168Increased serum lactate (HP:0002151)1.62725007
169Dandy-Walker malformation (HP:0001305)1.61240208
170Decreased central vision (HP:0007663)1.60590925
171Neonatal respiratory distress (HP:0002643)1.59576542
172Glioma (HP:0009733)1.59182995

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.86018585
2PINK13.36827699
3PBK3.23022458
4SRPK13.14972177
5MKNK22.73258955
6WNK42.66975339
7MKNK12.57096845
8EIF2AK12.50901241
9CDC72.50844960
10PLK42.41391338
11IRAK42.37426666
12EIF2AK32.26442769
13CASK2.22875034
14BUB12.19742053
15WNK32.08095900
16VRK11.99566428
17NUAK11.96715080
18WEE11.95371212
19MST41.92396039
20CDK81.88333364
21PNCK1.83689157
22INSRR1.79009757
23STK161.69641093
24MUSK1.62698584
25IRAK31.56593301
26PLK11.52438269
27VRK21.52119268
28MELK1.51151018
29EIF2AK21.47689881
30TLK11.46507508
31BMPR21.41630436
32TTK1.40073536
33TAOK31.39787504
34TNIK1.32349900
35PAK31.31461461
36TRIM281.26918607
37PLK31.25848477
38BMPR1B1.22499471
39PIM21.21801166
40MAPK131.21649326
41RPS6KA41.20208138
42BRSK21.18158392
43TXK1.16526015
44DMPK1.16493253
45MAP4K21.13018788
46DYRK31.11882233
47NME21.10677064
48AURKB1.09242469
49CCNB11.08915418
50DAPK21.06756109
51ATR1.06292652
52CDK31.05447745
53PRKCG1.05347747
54BCR1.05060099
55ADRBK21.04303082
56STK391.03120913
57ADRBK11.01567628
58PLK21.00812041
59RPS6KA51.00626564
60IKBKB0.99905616
61NME10.94327114
62IRAK20.93278899
63MAP2K70.92970160
64MAP3K120.92353403
65NTRK30.91942200
66GRK70.90614870
67MAP3K40.89911513
68OXSR10.89270545
69BLK0.88759718
70CDK70.84392895
71TGFBR10.83987387
72CHEK20.83910678
73PIK3CA0.83683971
74IRAK10.83474915
75MAPK150.81937463
76DYRK20.79543066
77CSNK1G20.78634792
78AURKA0.77883865
79MAP3K140.77819888
80TEC0.77441824
81CLK10.77181474
82AKT30.76175735
83ZAK0.75570024
84STK38L0.75015832
85STK40.74968320
86YES10.74657151
87NLK0.73827892
88ACVR1B0.71887320
89PRKCE0.71581444
90CSNK2A10.70872239
91CHUK0.69045451
92NEK20.67246956
93ATM0.66522981
94TSSK60.66173203
95NEK10.65825828
96NEK60.65593552
97BRD40.65048400
98BRAF0.63680059
99CHEK10.62362008
100CSNK2A20.62075326
101PAK60.61158068
102BRSK10.60505122
103PKN10.59269182
104PIM10.57673968
105PIK3CG0.56067424
106CSNK1A10.54850689
107PRKACB0.53736006
108PHKG20.52892505
109PHKG10.52892505
110IKBKE0.52618509
111TAF10.51745987
112CAMK2A0.51570597
113CSNK1D0.50514132
114MAP3K60.50507087
115MARK10.49765195
116CAMK1G0.49483830
117LYN0.49231914
118NTRK20.48928937
119EPHA20.47747378
120CSNK1E0.47674130
121PRKACA0.46466381
122CDK190.46440908
123STK30.46162092
124SIK30.45225522
125PRKCI0.44680936
126CSNK1G30.44086058
127CDK10.42381694
128CSNK1G10.40945058
129ERBB40.40559910
130FGR0.40041376
131GRK10.39188566
132PTK2B0.39093531
133MAPKAPK50.38868946
134PRKG10.38842487
135KIT0.38738697
136ABL20.38685149
137CDK20.37077520
138CAMK2D0.36210704
139STK100.36129935
140CAMK10.36056698
141WNK10.35017954
142PASK0.34986594
143STK110.34943918
144CSNK1A1L0.34205315
145PRKCQ0.34185428
146CDK90.31894966
147OBSCN0.31389003

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.76547292
2RNA polymerase_Homo sapiens_hsa030203.45855021
3Proteasome_Homo sapiens_hsa030503.37909176
4Homologous recombination_Homo sapiens_hsa034402.92158713
5DNA replication_Homo sapiens_hsa030302.78383852
6Protein export_Homo sapiens_hsa030602.75090225
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.73754831
8Basal transcription factors_Homo sapiens_hsa030222.73750673
9Non-homologous end-joining_Homo sapiens_hsa034502.69537548
10Spliceosome_Homo sapiens_hsa030402.63077551
11Oxidative phosphorylation_Homo sapiens_hsa001902.44927812
12Mismatch repair_Homo sapiens_hsa034302.41840913
13Selenocompound metabolism_Homo sapiens_hsa004502.18339497
14Nucleotide excision repair_Homo sapiens_hsa034202.10986173
15Fanconi anemia pathway_Homo sapiens_hsa034602.09183852
16RNA transport_Homo sapiens_hsa030132.08200563
17RNA degradation_Homo sapiens_hsa030182.05899948
18Pyrimidine metabolism_Homo sapiens_hsa002402.02191526
19Tryptophan metabolism_Homo sapiens_hsa003801.96927890
20Cell cycle_Homo sapiens_hsa041101.92287020
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.89642576
22Parkinsons disease_Homo sapiens_hsa050121.87513788
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.83968491
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.83301635
25Huntingtons disease_Homo sapiens_hsa050161.81148762
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.80696552
27Nitrogen metabolism_Homo sapiens_hsa009101.79396209
28Base excision repair_Homo sapiens_hsa034101.79248472
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.65614949
30Butanoate metabolism_Homo sapiens_hsa006501.59667211
31Nicotine addiction_Homo sapiens_hsa050331.43113866
32Caffeine metabolism_Homo sapiens_hsa002321.39199590
33Allograft rejection_Homo sapiens_hsa053301.36341168
34Alzheimers disease_Homo sapiens_hsa050101.36093035
35Propanoate metabolism_Homo sapiens_hsa006401.34770597
36Graft-versus-host disease_Homo sapiens_hsa053321.27248112
37beta-Alanine metabolism_Homo sapiens_hsa004101.26899050
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23246086
39Histidine metabolism_Homo sapiens_hsa003401.22861027
40mRNA surveillance pathway_Homo sapiens_hsa030151.20561149
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17769536
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17627391
43Purine metabolism_Homo sapiens_hsa002301.15839229
44Autoimmune thyroid disease_Homo sapiens_hsa053201.14654839
45Asthma_Homo sapiens_hsa053101.12868393
46Primary bile acid biosynthesis_Homo sapiens_hsa001201.12396166
47Pentose and glucuronate interconversions_Homo sapiens_hsa000401.09024664
48p53 signaling pathway_Homo sapiens_hsa041151.08604460
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08281890
50Epstein-Barr virus infection_Homo sapiens_hsa051691.07507564
51Herpes simplex infection_Homo sapiens_hsa051681.02561842
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01572635
53Taste transduction_Homo sapiens_hsa047420.97187432
54Peroxisome_Homo sapiens_hsa041460.95603553
55Rheumatoid arthritis_Homo sapiens_hsa053230.92914544
56Pyruvate metabolism_Homo sapiens_hsa006200.91312540
57Primary immunodeficiency_Homo sapiens_hsa053400.90750638
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.90362604
59Arachidonic acid metabolism_Homo sapiens_hsa005900.89993039
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.87787111
61Ether lipid metabolism_Homo sapiens_hsa005650.87220485
62Insulin secretion_Homo sapiens_hsa049110.86069551
63Chemical carcinogenesis_Homo sapiens_hsa052040.86023253
64Olfactory transduction_Homo sapiens_hsa047400.85916237
65Retinol metabolism_Homo sapiens_hsa008300.84578822
66ABC transporters_Homo sapiens_hsa020100.84328824
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84304437
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.80507285
69Sphingolipid metabolism_Homo sapiens_hsa006000.80101279
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78689151
71Fatty acid degradation_Homo sapiens_hsa000710.77470758
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76790185
73Hematopoietic cell lineage_Homo sapiens_hsa046400.76443577
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73388795
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69251113
76Phototransduction_Homo sapiens_hsa047440.67963906
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.66730943
78Collecting duct acid secretion_Homo sapiens_hsa049660.66628842
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66357269
80Glycerolipid metabolism_Homo sapiens_hsa005610.65242246
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65107105
82Morphine addiction_Homo sapiens_hsa050320.65069514
83Circadian entrainment_Homo sapiens_hsa047130.64971538
84Regulation of autophagy_Homo sapiens_hsa041400.64872703
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62391532
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62017071
87Type I diabetes mellitus_Homo sapiens_hsa049400.61492527
88Mineral absorption_Homo sapiens_hsa049780.60637966
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60632836
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60034586
91Cardiac muscle contraction_Homo sapiens_hsa042600.58899700
92Lysine degradation_Homo sapiens_hsa003100.58810765
93Measles_Homo sapiens_hsa051620.58068622
94Malaria_Homo sapiens_hsa051440.57823303
95Linoleic acid metabolism_Homo sapiens_hsa005910.57567323
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57536670
97Phagosome_Homo sapiens_hsa041450.57492853
98Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56908131
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54952829
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53919390
101Glutamatergic synapse_Homo sapiens_hsa047240.52334291
102Antigen processing and presentation_Homo sapiens_hsa046120.51921572
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51903452
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51800636
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50997919
106GABAergic synapse_Homo sapiens_hsa047270.50517543
107Calcium signaling pathway_Homo sapiens_hsa040200.49983676
108Oocyte meiosis_Homo sapiens_hsa041140.49803782
109Folate biosynthesis_Homo sapiens_hsa007900.49366045
110Leishmaniasis_Homo sapiens_hsa051400.47611799
111One carbon pool by folate_Homo sapiens_hsa006700.46792522
112HTLV-I infection_Homo sapiens_hsa051660.44853967
113Salivary secretion_Homo sapiens_hsa049700.42265400
114TGF-beta signaling pathway_Homo sapiens_hsa043500.41545297
115Systemic lupus erythematosus_Homo sapiens_hsa053220.39781417
116Dopaminergic synapse_Homo sapiens_hsa047280.39631654
117MicroRNAs in cancer_Homo sapiens_hsa052060.38998712
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38949221
119Steroid biosynthesis_Homo sapiens_hsa001000.38073984
120Wnt signaling pathway_Homo sapiens_hsa043100.37542214
121Viral carcinogenesis_Homo sapiens_hsa052030.36890500
122Arginine and proline metabolism_Homo sapiens_hsa003300.36352938
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36280420
124Serotonergic synapse_Homo sapiens_hsa047260.35657297
125Vibrio cholerae infection_Homo sapiens_hsa051100.35378194
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35293603
127Long-term depression_Homo sapiens_hsa047300.35015482
128Shigellosis_Homo sapiens_hsa051310.34484453
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.33559922
130Circadian rhythm_Homo sapiens_hsa047100.33281541
131African trypanosomiasis_Homo sapiens_hsa051430.32312892
132Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31613122
133Influenza A_Homo sapiens_hsa051640.31554345
134Cocaine addiction_Homo sapiens_hsa050300.31524023
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31021149
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30832907
137Glutathione metabolism_Homo sapiens_hsa004800.30455472
138Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30301739
139Basal cell carcinoma_Homo sapiens_hsa052170.30128573
140Legionellosis_Homo sapiens_hsa051340.30023467
141Pertussis_Homo sapiens_hsa051330.28720588
142Prostate cancer_Homo sapiens_hsa052150.27108937
143Pancreatic secretion_Homo sapiens_hsa049720.25958132
144Hedgehog signaling pathway_Homo sapiens_hsa043400.25422428
145Hepatitis B_Homo sapiens_hsa051610.24455578
146Vitamin digestion and absorption_Homo sapiens_hsa049770.24381879
147Pathways in cancer_Homo sapiens_hsa052000.24130657
148Apoptosis_Homo sapiens_hsa042100.22835193
149T cell receptor signaling pathway_Homo sapiens_hsa046600.21168654
150Metabolic pathways_Homo sapiens_hsa011000.20365101
151Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.20185927
152Tuberculosis_Homo sapiens_hsa051520.18534608

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