NSRP1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.38876814
2protein complex biogenesis (GO:0070271)4.79905506
3cytochrome complex assembly (GO:0017004)4.57138580
4mitochondrial respiratory chain complex assembly (GO:0033108)4.50702008
5respiratory chain complex IV assembly (GO:0008535)4.37468581
6synaptic transmission, cholinergic (GO:0007271)4.29470980
7mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.66569635
8mitochondrial respiratory chain complex I assembly (GO:0032981)3.66569635
9NADH dehydrogenase complex assembly (GO:0010257)3.66569635
10fucose catabolic process (GO:0019317)3.64012434
11L-fucose metabolic process (GO:0042354)3.64012434
12L-fucose catabolic process (GO:0042355)3.64012434
13negative regulation of translation, ncRNA-mediated (GO:0040033)3.63653851
14regulation of translation, ncRNA-mediated (GO:0045974)3.63653851
15negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.63653851
16response to pheromone (GO:0019236)3.59790373
17head development (GO:0060322)3.59725471
18alanine transport (GO:0032328)3.59547568
19regulation of hexokinase activity (GO:1903299)3.54284511
20regulation of glucokinase activity (GO:0033131)3.54284511
21ATP synthesis coupled proton transport (GO:0015986)3.53530843
22energy coupled proton transport, down electrochemical gradient (GO:0015985)3.53530843
23detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.51099460
24detection of light stimulus involved in visual perception (GO:0050908)3.46117318
25detection of light stimulus involved in sensory perception (GO:0050962)3.46117318
26intraciliary transport (GO:0042073)3.45775259
27proline transport (GO:0015824)3.42519503
28mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.41839953
29epithelial cilium movement (GO:0003351)3.37532767
30protein-cofactor linkage (GO:0018065)3.31437886
31auditory receptor cell differentiation (GO:0042491)3.23808396
32establishment of protein localization to Golgi (GO:0072600)3.12754117
33water-soluble vitamin biosynthetic process (GO:0042364)3.04881896
34protein polyglutamylation (GO:0018095)3.00426842
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.00275030
36postsynaptic membrane organization (GO:0001941)2.97185587
37protein localization to cilium (GO:0061512)2.94630830
38endoderm formation (GO:0001706)2.93622200
39DNA deamination (GO:0045006)2.93315500
40axoneme assembly (GO:0035082)2.87960562
41transmission of nerve impulse (GO:0019226)2.85586779
42Sertoli cell development (GO:0060009)2.84266994
43epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.83572051
44negative regulation of cytosolic calcium ion concentration (GO:0051481)2.78546780
45respiratory electron transport chain (GO:0022904)2.77987128
46retinal cone cell development (GO:0046549)2.77448582
47electron transport chain (GO:0022900)2.77194145
48somite development (GO:0061053)2.75878379
49cellular ketone body metabolic process (GO:0046950)2.74166168
50replication fork processing (GO:0031297)2.73970342
51protein K6-linked ubiquitination (GO:0085020)2.71860048
52negative regulation of reactive oxygen species metabolic process (GO:2000378)2.69460471
53cilium movement (GO:0003341)2.67926428
54adaptation of signaling pathway (GO:0023058)2.66793514
55startle response (GO:0001964)2.64403332
56photoreceptor cell development (GO:0042461)2.63196155
57protein targeting to Golgi (GO:0000042)2.61701967
58regulation of mitochondrial translation (GO:0070129)2.60850927
59ATP biosynthetic process (GO:0006754)2.60516491
60platelet dense granule organization (GO:0060155)2.60276727
61purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.58774409
62dopamine transport (GO:0015872)2.58391381
63peptidyl-histidine modification (GO:0018202)2.57180102
64behavioral response to ethanol (GO:0048149)2.57045061
65retina development in camera-type eye (GO:0060041)2.56232947
66retrograde transport, vesicle recycling within Golgi (GO:0000301)2.56203325
67response to nitrosative stress (GO:0051409)2.55119728
68purine nucleoside triphosphate biosynthetic process (GO:0009145)2.54881961
69cilium morphogenesis (GO:0060271)2.54475497
70GTP biosynthetic process (GO:0006183)2.53257816
71retinal rod cell development (GO:0046548)2.53216726
72olfactory bulb development (GO:0021772)2.51210139
73regulation of action potential (GO:0098900)2.51135036
74hindbrain development (GO:0030902)2.49758702
75N-glycan processing (GO:0006491)2.49730729
76ubiquinone metabolic process (GO:0006743)2.48068628
77regulation of calcium ion-dependent exocytosis (GO:0017158)2.47053071
78piRNA metabolic process (GO:0034587)2.46317710
79snRNA transcription (GO:0009301)2.45451331
80cilium organization (GO:0044782)2.44063938
81indolalkylamine metabolic process (GO:0006586)2.42980273
82primary amino compound metabolic process (GO:1901160)2.42818770
83preassembly of GPI anchor in ER membrane (GO:0016254)2.42493112
84hydrogen ion transmembrane transport (GO:1902600)2.41718363
85renal tubule morphogenesis (GO:0061333)2.41584542
86proton transport (GO:0015992)2.40509489
87positive regulation of histone H3-K4 methylation (GO:0051571)2.40306915
88kidney morphogenesis (GO:0060993)2.38465308
89neuronal action potential (GO:0019228)2.38435392
90DNA-dependent DNA replication (GO:0006261)2.37869751
91protein localization to Golgi apparatus (GO:0034067)2.37380818
92ketone body metabolic process (GO:1902224)2.36730040
93retina layer formation (GO:0010842)2.36706732
94spinal cord motor neuron differentiation (GO:0021522)2.35855809
95regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.34368516
96hydrogen transport (GO:0006818)2.33615145
97photoreceptor cell maintenance (GO:0045494)2.33563936
98eye photoreceptor cell development (GO:0042462)2.32874227
99cilium assembly (GO:0042384)2.31664714
100substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.31546917

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.42387135
2ZNF274_21170338_ChIP-Seq_K562_Hela3.30019915
3VDR_22108803_ChIP-Seq_LS180_Human3.17765724
4EZH2_22144423_ChIP-Seq_EOC_Human2.73376360
5GBX2_23144817_ChIP-Seq_PC3_Human2.51410094
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.24045193
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23534175
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.19182787
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.14676368
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13140481
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.08705469
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.05012526
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.03020867
14CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96480621
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95636147
16POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89533467
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87505650
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.79350855
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77151504
20BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73148431
21REST_21632747_ChIP-Seq_MESCs_Mouse1.70804098
22P300_19829295_ChIP-Seq_ESCs_Human1.70670839
23FUS_26573619_Chip-Seq_HEK293_Human1.70161282
24IGF1R_20145208_ChIP-Seq_DFB_Human1.66273806
25ER_23166858_ChIP-Seq_MCF-7_Human1.61905005
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59956790
27TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56085995
28POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.56085995
29GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.55508890
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.55116832
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52968230
32MYC_18940864_ChIP-ChIP_HL60_Human1.49851609
33STAT3_23295773_ChIP-Seq_U87_Human1.44107092
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43206934
35SMAD4_21799915_ChIP-Seq_A2780_Human1.42451925
36TP53_22573176_ChIP-Seq_HFKS_Human1.40944341
37ETV2_25802403_ChIP-Seq_MESCs_Mouse1.38274644
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37217461
39EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.37092501
40ELK1_19687146_ChIP-ChIP_HELA_Human1.35524380
41BCAT_22108803_ChIP-Seq_LS180_Human1.35522429
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34138388
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33893797
44CBP_20019798_ChIP-Seq_JUKART_Human1.33672644
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33672644
46NCOR_22424771_ChIP-Seq_293T_Human1.33568767
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32614126
48TAF15_26573619_Chip-Seq_HEK293_Human1.32036772
49TCF4_23295773_ChIP-Seq_U87_Human1.29962158
50SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.29538571
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.28411860
52RNF2_27304074_Chip-Seq_NSC_Mouse1.28342683
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28243577
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27874278
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.26981634
56NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23961505
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23768258
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.23489016
59AR_25329375_ChIP-Seq_VCAP_Human1.22885128
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22423061
61EWS_26573619_Chip-Seq_HEK293_Human1.22200992
62DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.21001925
63EST1_17652178_ChIP-ChIP_JURKAT_Human1.20074448
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19666964
65ETS1_20019798_ChIP-Seq_JURKAT_Human1.19640338
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19240390
67REST_18959480_ChIP-ChIP_MESCs_Mouse1.18911703
68EZH2_27304074_Chip-Seq_ESCs_Mouse1.18782463
69JARID2_20064375_ChIP-Seq_MESCs_Mouse1.17222420
70NANOG_19829295_ChIP-Seq_ESCs_Human1.16510699
71SOX2_19829295_ChIP-Seq_ESCs_Human1.16510699
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16306215
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.15127518
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12174803
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.12174803
76AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11990951
77JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11773707
78CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11671387
79P53_22387025_ChIP-Seq_ESCs_Mouse1.11505298
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10735930
81CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.10727133
82HTT_18923047_ChIP-ChIP_STHdh_Human1.10557585
83STAT3_18555785_Chip-Seq_ESCs_Mouse1.08462904
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07292224
85EZH2_27294783_Chip-Seq_NPCs_Mouse1.06319793
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06016849
87EZH2_27294783_Chip-Seq_ESCs_Mouse1.04303407
88TCF4_22108803_ChIP-Seq_LS180_Human1.03660820
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.02488566
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.02151622
91JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01765430
92NFE2_27457419_Chip-Seq_LIVER_Mouse1.01644386
93EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01402620
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01242945
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00610780
96P300_18555785_Chip-Seq_ESCs_Mouse1.00593964
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00544258
98EED_16625203_ChIP-ChIP_MESCs_Mouse1.00356127
99AR_20517297_ChIP-Seq_VCAP_Human1.00342226
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00311288

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006072_abnormal_retinal_apoptosis3.48535237
2MP0003787_abnormal_imprinting3.24380107
3MP0002837_dystrophic_cardiac_calcinosis2.98132587
4MP0008877_abnormal_DNA_methylation2.77815184
5MP0009046_muscle_twitch2.67988665
6MP0004147_increased_porphyrin_level2.40654087
7MP0004885_abnormal_endolymph2.28946349
8MP0003121_genomic_imprinting2.28859465
9MP0003195_calcinosis2.12420283
10MP0005551_abnormal_eye_electrophysiolog2.11081315
11MP0003283_abnormal_digestive_organ2.07171918
12MP0002138_abnormal_hepatobiliary_system2.06014939
13MP0002638_abnormal_pupillary_reflex2.01076343
14MP0009745_abnormal_behavioral_response1.96236512
15MP0002272_abnormal_nervous_system1.93170721
16MP0006292_abnormal_olfactory_placode1.89774720
17MP0009379_abnormal_foot_pigmentation1.88767283
18MP0001968_abnormal_touch/_nociception1.86677703
19MP0001485_abnormal_pinna_reflex1.83973339
20MP0003879_abnormal_hair_cell1.82179255
21MP0002876_abnormal_thyroid_physiology1.79187506
22MP0005645_abnormal_hypothalamus_physiol1.76136324
23MP0003122_maternal_imprinting1.75037268
24MP0005253_abnormal_eye_physiology1.73509853
25MP0003880_abnormal_central_pattern1.67624171
26MP0000569_abnormal_digit_pigmentation1.66158334
27MP0002557_abnormal_social/conspecific_i1.65916775
28MP0004142_abnormal_muscle_tone1.65120105
29MP0005174_abnormal_tail_pigmentation1.64001229
30MP0000778_abnormal_nervous_system1.62543318
31MP0002102_abnormal_ear_morphology1.60161000
32MP0003646_muscle_fatigue1.57468308
33MP0001486_abnormal_startle_reflex1.56888409
34MP0008875_abnormal_xenobiotic_pharmacok1.53921583
35MP0002938_white_spotting1.52496615
36MP0005084_abnormal_gallbladder_morpholo1.47415329
37MP0002572_abnormal_emotion/affect_behav1.47385014
38MP0002064_seizures1.45434698
39MP0004924_abnormal_behavior1.40216530
40MP0005386_behavior/neurological_phenoty1.40216530
41MP0002736_abnormal_nociception_after1.39422571
42MP0003635_abnormal_synaptic_transmissio1.38141183
43MP0008995_early_reproductive_senescence1.37959315
44MP0001984_abnormal_olfaction1.36879485
45MP0001986_abnormal_taste_sensitivity1.35785222
46MP0004145_abnormal_muscle_electrophysio1.35510122
47MP0001905_abnormal_dopamine_level1.32349398
48MP0006276_abnormal_autonomic_nervous1.28983222
49MP0004133_heterotaxia1.25802802
50MP0002067_abnormal_sensory_capabilities1.22688435
51MP0005379_endocrine/exocrine_gland_phen1.21355582
52MP0001963_abnormal_hearing_physiology1.20842499
53MP0002063_abnormal_learning/memory/cond1.19475128
54MP0002752_abnormal_somatic_nervous1.19465820
55MP0008872_abnormal_physiological_respon1.18494903
56MP0002733_abnormal_thermal_nociception1.17906151
57MP0005195_abnormal_posterior_eye1.16649505
58MP0002184_abnormal_innervation1.16490751
59MP0002160_abnormal_reproductive_system1.16332113
60MP0002095_abnormal_skin_pigmentation1.15363769
61MP0001970_abnormal_pain_threshold1.14224161
62MP0004043_abnormal_pH_regulation1.12868528
63MP0001529_abnormal_vocalization1.12631637
64MP0001188_hyperpigmentation1.11804378
65MP0002734_abnormal_mechanical_nocicepti1.11720026
66MP0002735_abnormal_chemical_nociception1.11603349
67MP0002822_catalepsy1.10934441
68MP0000026_abnormal_inner_ear1.09462997
69MP0003011_delayed_dark_adaptation1.08499858
70MP0003186_abnormal_redox_activity1.08073503
71MP0000647_abnormal_sebaceous_gland1.07989368
72MP0002909_abnormal_adrenal_gland1.07338443
73MP0001501_abnormal_sleep_pattern1.06059714
74MP0000955_abnormal_spinal_cord1.05999321
75MP0001944_abnormal_pancreas_morphology1.04905486
76MP0002928_abnormal_bile_duct1.00864940
77MP0003633_abnormal_nervous_system1.00462759
78MP0001324_abnormal_eye_pigmentation0.99703579
79MP0000015_abnormal_ear_pigmentation0.99248878
80MP0000427_abnormal_hair_cycle0.97843244
81MP0002229_neurodegeneration0.97091273
82MP0002234_abnormal_pharynx_morphology0.96490511
83MP0002882_abnormal_neuron_morphology0.95284928
84MP0002693_abnormal_pancreas_physiology0.94261184
85MP0000631_abnormal_neuroendocrine_gland0.94124123
86MP0006036_abnormal_mitochondrial_physio0.93337239
87MP0000049_abnormal_middle_ear0.91507761
88MP0008775_abnormal_heart_ventricle0.90930606
89MP0005646_abnormal_pituitary_gland0.90837452
90MP0004742_abnormal_vestibular_system0.87125015
91MP0001440_abnormal_grooming_behavior0.86527448
92MP0005389_reproductive_system_phenotype0.85282135
93MP0002163_abnormal_gland_morphology0.81538971
94MP0003937_abnormal_limbs/digits/tail_de0.76696216
95MP0003718_maternal_effect0.75460580
96MP0001502_abnormal_circadian_rhythm0.73635379
97MP0003123_paternal_imprinting0.73489254
98MP0003890_abnormal_embryonic-extraembry0.73099180
99MP0003567_abnormal_fetal_cardiomyocyte0.72753611
100MP0003252_abnormal_bile_duct0.72435929

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic fibrosis (HP:0100732)4.07547593
2Papilledema (HP:0001085)3.92351477
3Congenital stationary night blindness (HP:0007642)3.83795133
4Nephronophthisis (HP:0000090)3.82970729
5Pancreatic cysts (HP:0001737)3.73497264
6Acute necrotizing encephalopathy (HP:0006965)3.51913425
7Molar tooth sign on MRI (HP:0002419)3.48655890
8Abnormality of midbrain morphology (HP:0002418)3.48655890
9Severe visual impairment (HP:0001141)3.43489195
10Abnormal rod and cone electroretinograms (HP:0008323)3.34765734
11True hermaphroditism (HP:0010459)3.31804427
12Volvulus (HP:0002580)3.30113787
13Abnormality of the renal medulla (HP:0100957)3.23629158
14Genetic anticipation (HP:0003743)3.16034091
15Progressive macrocephaly (HP:0004481)3.11744857
16Abnormality of the renal cortex (HP:0011035)3.09750105
17Mitochondrial inheritance (HP:0001427)2.95921935
18Tubular atrophy (HP:0000092)2.92995055
19Abnormal mitochondria in muscle tissue (HP:0008316)2.90580759
20Type II lissencephaly (HP:0007260)2.83431675
21Acute encephalopathy (HP:0006846)2.81940184
22Intestinal atresia (HP:0011100)2.74530566
23Large for gestational age (HP:0001520)2.69337617
24Absent speech (HP:0001344)2.67583538
25Renal cortical cysts (HP:0000803)2.66233722
26Bile duct proliferation (HP:0001408)2.64135071
27Abnormal biliary tract physiology (HP:0012439)2.64135071
28Increased CSF lactate (HP:0002490)2.60173293
29Shawl scrotum (HP:0000049)2.58904117
30Aplasia/Hypoplasia of the fovea (HP:0008060)2.55840701
31Hypoplasia of the fovea (HP:0007750)2.55840701
32Cystic liver disease (HP:0006706)2.53243859
33Hemiparesis (HP:0001269)2.51724975
34Hepatic necrosis (HP:0002605)2.50279921
35Increased hepatocellular lipid droplets (HP:0006565)2.48805361
36Hepatocellular necrosis (HP:0001404)2.48099457
37Lipid accumulation in hepatocytes (HP:0006561)2.46903327
38Abnormal drinking behavior (HP:0030082)2.44325458
39Polydipsia (HP:0001959)2.44325458
40Medial flaring of the eyebrow (HP:0010747)2.44109555
41Hyperventilation (HP:0002883)2.37896064
42Optic nerve hypoplasia (HP:0000609)2.37837531
43Polyphagia (HP:0002591)2.34694828
44Chronic hepatic failure (HP:0100626)2.30119922
45Aplasia/Hypoplasia of the spleen (HP:0010451)2.27017868
46Severe muscular hypotonia (HP:0006829)2.24178748
47Focal seizures (HP:0007359)2.23047282
48Small hand (HP:0200055)2.21589207
49Gaze-evoked nystagmus (HP:0000640)2.19939245
50Abnormality of macular pigmentation (HP:0008002)2.19674083
51Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.19303576
52Congenital hepatic fibrosis (HP:0002612)2.18934913
53Progressive cerebellar ataxia (HP:0002073)2.17943933
543-Methylglutaconic aciduria (HP:0003535)2.17410768
55Cerebellar dysplasia (HP:0007033)2.16768104
56Pendular nystagmus (HP:0012043)2.16394899
57Congenital sensorineural hearing impairment (HP:0008527)2.13687444
58Sclerocornea (HP:0000647)2.12117928
59Absent rod-and cone-mediated responses on ERG (HP:0007688)2.11056431
60Aplasia/Hypoplasia of the tongue (HP:0010295)2.08993456
61Abnormality of the fovea (HP:0000493)2.05328939
62Asplenia (HP:0001746)2.04393075
63Cerebral edema (HP:0002181)2.04124747
64Attenuation of retinal blood vessels (HP:0007843)2.00773446
65Optic disc pallor (HP:0000543)1.99326055
66Glycosuria (HP:0003076)1.99124325
67Abnormality of urine glucose concentration (HP:0011016)1.99124325
68Prolonged QT interval (HP:0001657)1.98947498
69Aplasia/Hypoplasia of the tibia (HP:0005772)1.95832105
70Pachygyria (HP:0001302)1.95060767
71Congenital, generalized hypertrichosis (HP:0004540)1.93013737
72Febrile seizures (HP:0002373)1.89091756
73Anencephaly (HP:0002323)1.86097106
74Oligodactyly (hands) (HP:0001180)1.84892043
75Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83576804
76Abnormal pancreas size (HP:0012094)1.82982247
77Polyuria (HP:0000103)1.82622663
78Methylmalonic acidemia (HP:0002912)1.82255536
79Male pseudohermaphroditism (HP:0000037)1.81270970
80Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.80064687
81Disproportionate short-trunk short stature (HP:0003521)1.79807094
82Lissencephaly (HP:0001339)1.79608448
83Dialeptic seizures (HP:0011146)1.79033765
84Gait imbalance (HP:0002141)1.78319396
85Abolished electroretinogram (ERG) (HP:0000550)1.77044541
86Ectopic kidney (HP:0000086)1.76760277
87Constricted visual fields (HP:0001133)1.75162135
88Methylmalonic aciduria (HP:0012120)1.73703903
89Abnormality of renal resorption (HP:0011038)1.73284312
90Hypothermia (HP:0002045)1.71646839
91Furrowed tongue (HP:0000221)1.70979429
92Albinism (HP:0001022)1.70281148
93Rib fusion (HP:0000902)1.70225796
94Type 2 muscle fiber atrophy (HP:0003554)1.67630789
95Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.66191808
96Degeneration of the lateral corticospinal tracts (HP:0002314)1.66191808
97Ketosis (HP:0001946)1.64657635
98Anophthalmia (HP:0000528)1.63960258
99Abnormality of the pons (HP:0007361)1.63117146
100Broad-based gait (HP:0002136)1.62732540

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.34624445
2PINK13.88402764
3CASK2.72246027
4STK162.68467170
5NUAK12.54505667
6ADRBK22.44351830
7BMPR1B2.42142765
8PAK32.31314512
9WNK32.26950355
10EPHB22.24030287
11NTRK32.16156355
12GRK12.07158127
13WNK41.88783329
14OXSR11.68107334
15MAPK131.57875320
16STK241.52655618
17MAP4K21.42923773
18PLK21.40499943
19MUSK1.40191961
20STK31.39545161
21MARK11.37812053
22PHKG21.31859846
23PHKG11.31859846
24DYRK1B1.30911872
25PTK2B1.30192805
26DYRK21.29103286
27CSNK1G21.26759995
28ZAK1.24244387
29NTRK21.19594455
30EPHA41.18924470
31STK111.13264789
32STK391.10185631
33MAP3K41.10145492
34CSNK1G31.09291161
35PRKCG1.08857123
36PAK61.07277791
37CDK191.04476735
38TXK1.04156206
39PRKCE1.01070296
40DAPK20.98010033
41CSNK1G10.97492880
42NME10.94892776
43CSNK1A1L0.93621366
44PRKCI0.90718397
45MAPKAPK50.87278584
46ADRBK10.80379028
47CAMK2D0.80101166
48TLK10.79705882
49TRPM70.77886520
50TAF10.76687011
51PRKCZ0.74651240
52TAOK30.73469025
53CSNK1E0.70852776
54CSNK1A10.70458356
55DYRK1A0.69342980
56CAMK2A0.66143670
57PRKCQ0.66078350
58CAMK10.66043424
59PRKACA0.65012529
60CAMKK20.63589334
61PRKG10.63568478
62MARK30.63430681
63SGK10.62608701
64ACVR1B0.62395531
65INSRR0.61373093
66MAP2K60.61104290
67VRK20.60430819
68MARK20.58014141
69PNCK0.56858012
70BCKDK0.54989449
71PIK3CA0.54880217
72MINK10.54684541
73MAP3K90.52975318
74PRKACB0.47937438
75LIMK10.47339979
76MAP2K70.46677536
77CHEK20.43440462
78KSR10.43076984
79CAMK1G0.42601667
80CDK30.41810458
81PLK30.41288894
82SGK2230.41237025
83SGK4940.41237025
84CDK50.40924953
85CSNK1D0.40854093
86PRKAA10.39987309
87ATR0.39898617
88MST40.39507416
89MKNK20.39244110
90PASK0.39110789
91CDK140.39089463
92CHUK0.39042189
93CSNK2A20.38975213
94FER0.38864578
95SGK20.37775897
96DMPK0.37014794
97PRKAA20.36910616
98GRK50.36722731
99RPS6KA30.36465914
100ATM0.35812958

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.41831225
2Protein export_Homo sapiens_hsa030603.27160247
3Homologous recombination_Homo sapiens_hsa034402.79037762
4Parkinsons disease_Homo sapiens_hsa050122.44800008
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.38653275
6Nicotine addiction_Homo sapiens_hsa050332.28059527
7RNA polymerase_Homo sapiens_hsa030202.23512390
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.08888561
9Phototransduction_Homo sapiens_hsa047442.08720625
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.99951836
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.94457101
12Alzheimers disease_Homo sapiens_hsa050101.89716224
13Collecting duct acid secretion_Homo sapiens_hsa049661.88040367
14Huntingtons disease_Homo sapiens_hsa050161.82543180
15Insulin secretion_Homo sapiens_hsa049111.80263109
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.74766772
17Ribosome_Homo sapiens_hsa030101.74474344
18Cardiac muscle contraction_Homo sapiens_hsa042601.71969626
19Butanoate metabolism_Homo sapiens_hsa006501.70949484
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70142955
21Selenocompound metabolism_Homo sapiens_hsa004501.67130590
22Linoleic acid metabolism_Homo sapiens_hsa005911.61523532
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54384107
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.53930946
25Dorso-ventral axis formation_Homo sapiens_hsa043201.51798501
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46487399
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.46107303
28Vitamin B6 metabolism_Homo sapiens_hsa007501.39670056
29Basal transcription factors_Homo sapiens_hsa030221.37490491
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31756776
31Fanconi anemia pathway_Homo sapiens_hsa034601.29269016
32Tryptophan metabolism_Homo sapiens_hsa003801.27080182
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25730945
34Morphine addiction_Homo sapiens_hsa050321.24382668
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21225922
36Nitrogen metabolism_Homo sapiens_hsa009101.18186306
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17094786
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.16647832
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14486772
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12550451
41Taste transduction_Homo sapiens_hsa047421.12134214
42Peroxisome_Homo sapiens_hsa041461.11327328
43Folate biosynthesis_Homo sapiens_hsa007901.10412679
44Sulfur metabolism_Homo sapiens_hsa009201.07412218
45Ether lipid metabolism_Homo sapiens_hsa005651.03312620
46GABAergic synapse_Homo sapiens_hsa047271.03289340
47Olfactory transduction_Homo sapiens_hsa047400.98526225
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98479211
49Serotonergic synapse_Homo sapiens_hsa047260.97905463
50Synaptic vesicle cycle_Homo sapiens_hsa047210.96343636
51Propanoate metabolism_Homo sapiens_hsa006400.93214329
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91118944
53Caffeine metabolism_Homo sapiens_hsa002320.90441125
54Dopaminergic synapse_Homo sapiens_hsa047280.88586283
55Chemical carcinogenesis_Homo sapiens_hsa052040.86440232
56ABC transporters_Homo sapiens_hsa020100.86100902
57Pyrimidine metabolism_Homo sapiens_hsa002400.82897546
58Circadian entrainment_Homo sapiens_hsa047130.81003274
59Purine metabolism_Homo sapiens_hsa002300.80814628
60Glutamatergic synapse_Homo sapiens_hsa047240.77997402
61Fatty acid elongation_Homo sapiens_hsa000620.77494098
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.76448761
63RNA degradation_Homo sapiens_hsa030180.76132592
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74441385
65beta-Alanine metabolism_Homo sapiens_hsa004100.70723270
66Mineral absorption_Homo sapiens_hsa049780.69859708
67Metabolic pathways_Homo sapiens_hsa011000.69245023
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68744031
69Fatty acid metabolism_Homo sapiens_hsa012120.67509916
70Glycerolipid metabolism_Homo sapiens_hsa005610.67443947
71One carbon pool by folate_Homo sapiens_hsa006700.67411412
72Retinol metabolism_Homo sapiens_hsa008300.65095568
73Fatty acid degradation_Homo sapiens_hsa000710.62816555
74Amphetamine addiction_Homo sapiens_hsa050310.60202115
75Fat digestion and absorption_Homo sapiens_hsa049750.58327855
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57887714
77Non-homologous end-joining_Homo sapiens_hsa034500.56903246
78Calcium signaling pathway_Homo sapiens_hsa040200.56187646
79Proteasome_Homo sapiens_hsa030500.56130406
80Long-term depression_Homo sapiens_hsa047300.55576115
81Oxytocin signaling pathway_Homo sapiens_hsa049210.55197318
82Salivary secretion_Homo sapiens_hsa049700.51014177
83Glutathione metabolism_Homo sapiens_hsa004800.50731602
84Arachidonic acid metabolism_Homo sapiens_hsa005900.49336360
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49301285
86Cholinergic synapse_Homo sapiens_hsa047250.49244935
87RNA transport_Homo sapiens_hsa030130.47569293
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46658422
89Mismatch repair_Homo sapiens_hsa034300.43633853
90Renin secretion_Homo sapiens_hsa049240.43486565
91Cocaine addiction_Homo sapiens_hsa050300.42841256
92cAMP signaling pathway_Homo sapiens_hsa040240.42772695
93Lysine degradation_Homo sapiens_hsa003100.42133946
94Gastric acid secretion_Homo sapiens_hsa049710.41306624
95Steroid biosynthesis_Homo sapiens_hsa001000.40761895
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38863740
97Axon guidance_Homo sapiens_hsa043600.38813651
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38406579
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.35526541
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33559627

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