NSUN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1folic acid-containing compound biosynthetic process (GO:0009396)5.41929182
2DNA unwinding involved in DNA replication (GO:0006268)5.15763399
3nucleobase biosynthetic process (GO:0046112)4.79222355
4DNA replication initiation (GO:0006270)4.63686955
5formation of translation preinitiation complex (GO:0001731)4.62010829
6nuclear pore organization (GO:0006999)4.59841920
7IMP biosynthetic process (GO:0006188)4.55908946
8maturation of SSU-rRNA (GO:0030490)4.54732944
9DNA strand elongation involved in DNA replication (GO:0006271)4.47711602
10nuclear pore complex assembly (GO:0051292)4.39887614
11purine nucleobase biosynthetic process (GO:0009113)4.37510503
12ribosome assembly (GO:0042255)4.35348226
13protein localization to kinetochore (GO:0034501)4.30022097
14spliceosomal tri-snRNP complex assembly (GO:0000244)4.28097917
15mitotic nuclear envelope disassembly (GO:0007077)4.26842201
16DNA strand elongation (GO:0022616)4.24132980
17COPI coating of Golgi vesicle (GO:0048205)4.20962838
18Golgi transport vesicle coating (GO:0048200)4.20962838
19IMP metabolic process (GO:0046040)4.14042566
20DNA replication-dependent nucleosome assembly (GO:0006335)4.12246939
21DNA replication-dependent nucleosome organization (GO:0034723)4.12246939
22ribosomal small subunit assembly (GO:0000028)4.08691290
23mitotic sister chromatid cohesion (GO:0007064)4.03406590
24folic acid metabolic process (GO:0046655)3.98758373
25nuclear envelope disassembly (GO:0051081)3.97920465
26membrane disassembly (GO:0030397)3.97920465
27translational termination (GO:0006415)3.97850971
28viral transcription (GO:0019083)3.97673105
29ribosome biogenesis (GO:0042254)3.97303941
30telomere maintenance via semi-conservative replication (GO:0032201)3.92647694
31ribosomal large subunit biogenesis (GO:0042273)3.87097117
32regulation of translational termination (GO:0006449)3.79043140
33translational initiation (GO:0006413)3.76279416
34ribonucleoprotein complex biogenesis (GO:0022613)3.74965076
35translational elongation (GO:0006414)3.72236981
36regulation of RNA export from nucleus (GO:0046831)3.70061425
37protein localization to chromosome, centromeric region (GO:0071459)3.66612877
38regulation of translational fidelity (GO:0006450)3.65623556
39protein complex localization (GO:0031503)3.61323056
40mitotic metaphase plate congression (GO:0007080)3.60875249
41cellular protein complex localization (GO:0034629)3.60297842
42DNA replication checkpoint (GO:0000076)3.59601486
43DNA duplex unwinding (GO:0032508)3.57691090
44DNA geometric change (GO:0032392)3.54774703
45nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.52059789
46DNA deamination (GO:0045006)3.48027131
47telomere maintenance via recombination (GO:0000722)3.41881916
48rRNA processing (GO:0006364)3.41400931
49protein export from nucleus (GO:0006611)3.40506230
50pteridine-containing compound biosynthetic process (GO:0042559)3.37368252
51ribosomal small subunit biogenesis (GO:0042274)3.35786036
52regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.35435036
53tetrahydrofolate metabolic process (GO:0046653)3.34820433
54nucleobase-containing small molecule interconversion (GO:0015949)3.34156938
55regulation of spindle organization (GO:0090224)3.31783890
56rRNA metabolic process (GO:0016072)3.31195689
57chromosome condensation (GO:0030261)3.30314133
58mitotic recombination (GO:0006312)3.30197968
59pore complex assembly (GO:0046931)3.26968627
60DNA topological change (GO:0006265)3.25880964
61telomere maintenance via telomere lengthening (GO:0010833)3.22341116
62regulation of nucleobase-containing compound transport (GO:0032239)3.21090462
63SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.21009087
64regulation of DNA damage checkpoint (GO:2000001)3.16663636
65spliceosomal snRNP assembly (GO:0000387)3.14792497
66chromatin remodeling at centromere (GO:0031055)3.14009917
67negative regulation of mRNA processing (GO:0050686)3.13270776
68regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.13145688
69nuclear envelope organization (GO:0006998)3.12752390
70protein targeting to ER (GO:0045047)3.12041802
71proline biosynthetic process (GO:0006561)3.11902368
72metaphase plate congression (GO:0051310)3.11844276
73cellular protein complex disassembly (GO:0043624)3.11687602
74heterochromatin organization (GO:0070828)3.11471412
75negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.10942283
76cotranslational protein targeting to membrane (GO:0006613)3.10191582
77chaperone-mediated protein complex assembly (GO:0051131)3.09855579
78mRNA stabilization (GO:0048255)3.08716245
79RNA stabilization (GO:0043489)3.08716245
80folic acid-containing compound metabolic process (GO:0006760)3.08692727
81viral life cycle (GO:0019058)3.06373101
82glycine metabolic process (GO:0006544)3.05603997
83regulation of histone H3-K9 methylation (GO:0051570)3.03534420
84mitotic sister chromatid segregation (GO:0000070)3.03361692
85CENP-A containing nucleosome assembly (GO:0034080)3.03358953
86mitotic chromosome condensation (GO:0007076)3.01922835
87negative regulation of mRNA metabolic process (GO:1903312)3.01714737
88translesion synthesis (GO:0019985)3.00708056
89nucleotide-excision repair, DNA gap filling (GO:0006297)3.00245518
90DNA replication-independent nucleosome organization (GO:0034724)3.00114052
91DNA replication-independent nucleosome assembly (GO:0006336)3.00114052
92pseudouridine synthesis (GO:0001522)2.99802886
93peptidyl-arginine omega-N-methylation (GO:0035247)2.98162797
94somatic hypermutation of immunoglobulin genes (GO:0016446)2.97552544
95somatic diversification of immune receptors via somatic mutation (GO:0002566)2.97552544
96establishment of protein localization to endoplasmic reticulum (GO:0072599)2.97354882
97positive regulation of chromosome segregation (GO:0051984)2.92468671
98protein localization to endoplasmic reticulum (GO:0070972)2.91950762
99tRNA aminoacylation for protein translation (GO:0006418)2.91590199
100DNA synthesis involved in DNA repair (GO:0000731)2.91488004
101negative regulation of RNA splicing (GO:0033119)2.91287682
102regulation of posttranscriptional gene silencing (GO:0060147)2.90212783
103regulation of gene silencing by miRNA (GO:0060964)2.90212783
104regulation of gene silencing by RNA (GO:0060966)2.90212783
105sister chromatid segregation (GO:0000819)2.89870463
106regulation of mitotic spindle organization (GO:0060236)2.88873351
107DNA packaging (GO:0006323)2.88489312
108chromatin assembly or disassembly (GO:0006333)2.88445159
109protein complex disassembly (GO:0043241)2.88359982
110L-serine metabolic process (GO:0006563)2.85010604
111positive regulation of cell cycle checkpoint (GO:1901978)2.84827919
112mitotic G1 DNA damage checkpoint (GO:0031571)2.84626709
113nuclear-transcribed mRNA catabolic process (GO:0000956)2.83016830
114DNA conformation change (GO:0071103)2.82249267
115pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.82204434
116tRNA aminoacylation (GO:0043039)2.80793162
117amino acid activation (GO:0043038)2.80793162
118regulation of sister chromatid cohesion (GO:0007063)2.79568910
119activation of Rac GTPase activity (GO:0032863)2.79321251
120non-recombinational repair (GO:0000726)2.78588198
121double-strand break repair via nonhomologous end joining (GO:0006303)2.78588198
122regulation of histone H3-K27 methylation (GO:0061085)2.77965449
123mRNA transport (GO:0051028)2.77309417
124regulation of centrosome cycle (GO:0046605)2.74668672
125RNA catabolic process (GO:0006401)2.74195287
126pentose-phosphate shunt (GO:0006098)2.73407486
127establishment of viral latency (GO:0019043)2.73393294
128regulation of translational elongation (GO:0006448)2.73192435
129establishment of integrated proviral latency (GO:0075713)2.72262010
130postreplication repair (GO:0006301)2.72075532
131rRNA transcription (GO:0009303)2.64136954
132retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.64039375
133peptidyl-arginine N-methylation (GO:0035246)2.61464898
134peptidyl-arginine methylation (GO:0018216)2.61464898
135regulation of cell cycle checkpoint (GO:1901976)2.57359514
136histone arginine methylation (GO:0034969)2.56827457
137mitochondrial DNA metabolic process (GO:0032042)2.56725155
1383-UTR-mediated mRNA stabilization (GO:0070935)2.56292417
139viral mRNA export from host cell nucleus (GO:0046784)2.54116076
140positive regulation of DNA-dependent DNA replication (GO:2000105)2.53458013
141glucocorticoid receptor signaling pathway (GO:0042921)2.52636356
142regulation of chromosome segregation (GO:0051983)2.52356219
143mRNA export from nucleus (GO:0006406)2.51005691
144chromosome segregation (GO:0007059)2.50140645
145dosage compensation (GO:0007549)2.50048722
146RNA export from nucleus (GO:0006405)2.47149469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.33389126
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.43201554
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.95220896
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.67332592
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.30136336
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.12543203
7* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.77960076
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.72006366
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.70200622
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.43373198
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.33815881
12XRN2_22483619_ChIP-Seq_HELA_Human2.28329653
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.27969390
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.26047022
15* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.23455316
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.21781681
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.21671262
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.19036772
19AR_21909140_ChIP-Seq_LNCAP_Human2.18655057
20MYC_22102868_ChIP-Seq_BL_Human2.16248542
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.13867918
22TP63_17297297_ChIP-ChIP_HaCaT_Human2.05940301
23E2F1_21310950_ChIP-Seq_MCF-7_Human1.92587285
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.91347432
25* VDR_23849224_ChIP-Seq_CD4+_Human1.90413453
26* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84337845
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82871391
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82337857
29FOXP3_21729870_ChIP-Seq_TREG_Human1.76362556
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73729120
31* DCP1A_22483619_ChIP-Seq_HELA_Human1.71896189
32* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.71823912
33* GABP_19822575_ChIP-Seq_HepG2_Human1.71515251
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69940586
35ZFX_18555785_ChIP-Seq_MESCs_Mouse1.67427793
36TTF2_22483619_ChIP-Seq_HELA_Human1.63108142
37* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62855204
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60445820
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.59655647
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.58965536
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57929571
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54794083
43KDM5A_27292631_Chip-Seq_BREAST_Human1.54689624
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54502271
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.52403490
46SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.47054209
47CIITA_25753668_ChIP-Seq_RAJI_Human1.46837682
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45900971
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43450654
50CLOCK_20551151_ChIP-Seq_293T_Human1.40512452
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37952143
52* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35505490
53* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35271095
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30993039
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30264880
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28262897
57ELK1_19687146_ChIP-ChIP_HELA_Human1.27451739
58* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27331907
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25422636
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.25347605
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.24903545
62* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23492854
63* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22598814
64SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.22551558
65* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22355738
66VDR_21846776_ChIP-Seq_THP-1_Human1.21900233
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21850504
68TFEB_21752829_ChIP-Seq_HELA_Human1.20817453
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19459035
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.17482426
71ZNF263_19887448_ChIP-Seq_K562_Human1.17207497
72* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16725202
73* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14242471
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13250134
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13021477
76RACK7_27058665_Chip-Seq_MCF-7_Human1.12605024
77ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12415023
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.11834954
79E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11804520
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11271769
81* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09927595
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09076188
83TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08667941
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.08440776
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07551284
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06639888
87CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05605731
88SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05431356
89E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05398287
90NCOR1_26117541_ChIP-Seq_K562_Human1.04199275
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02877796
92TCF7_22412390_ChIP-Seq_EML_Mouse1.02293828
93* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01198270
94PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00833934
95PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00147884
96P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98886115
97SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97878838
98MAF_26560356_Chip-Seq_TH1_Human0.97817050
99KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96242731
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93916271
101NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93749435
102RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92497790
103* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.91260216
104BRD4_27068464_Chip-Seq_AML-cells_Mouse0.90800052
105SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.89812354
106TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89672077
107SRF_21415370_ChIP-Seq_HL-1_Mouse0.89475648
108SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89218040
109EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.88478691
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88002266
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87862324
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87460416
113GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86419255
114TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86017680
115MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.84772503
116ATF3_27146783_Chip-Seq_COLON_Human0.84194596
117CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82147236
118SPI1_23547873_ChIP-Seq_NB4_Human0.80702911
119MYC_18940864_ChIP-ChIP_HL60_Human0.79971406
120NANOG_21062744_ChIP-ChIP_HESCs_Human0.79535491
121OCT4_18692474_ChIP-Seq_MEFs_Mouse0.78856106
122CHD1_26751641_Chip-Seq_LNCaP_Human0.78472276
123TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77308242
124NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.76698108
125CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.76148675

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.89817678
2MP0004957_abnormal_blastocyst_morpholog4.35505464
3MP0010094_abnormal_chromosome_stability4.19438745
4MP0003111_abnormal_nucleus_morphology4.06807033
5MP0003077_abnormal_cell_cycle3.59284694
6MP0008057_abnormal_DNA_replication3.32308753
7MP0010352_gastrointestinal_tract_polyps3.08094098
8MP0003806_abnormal_nucleotide_metabolis2.74225241
9MP0005451_abnormal_body_composition2.65960294
10MP0001730_embryonic_growth_arrest2.62157620
11MP0008058_abnormal_DNA_repair2.61236139
12MP0008007_abnormal_cellular_replicative2.50954861
13MP0002396_abnormal_hematopoietic_system2.50077140
14MP0010307_abnormal_tumor_latency2.42510089
15MP0000350_abnormal_cell_proliferation2.30317846
16MP0003123_paternal_imprinting2.24941251
17MP0008932_abnormal_embryonic_tissue2.20841746
18MP0003705_abnormal_hypodermis_morpholog2.18204822
19MP0002009_preneoplasia2.16562684
20MP0001672_abnormal_embryogenesis/_devel1.84715900
21MP0005380_embryogenesis_phenotype1.84715900
22MP0001697_abnormal_embryo_size1.81801471
23MP0002080_prenatal_lethality1.76755666
24MP0000490_abnormal_crypts_of1.76571748
25MP0003984_embryonic_growth_retardation1.70810765
26MP0001661_extended_life_span1.69646990
27MP0002088_abnormal_embryonic_growth/wei1.68148351
28MP0004197_abnormal_fetal_growth/weight/1.63885988
29MP0002086_abnormal_extraembryonic_tissu1.63276078
30MP0008260_abnormal_autophagy1.63207899
31MP0002084_abnormal_developmental_patter1.60694101
32MP0002796_impaired_skin_barrier1.60226777
33MP0004808_abnormal_hematopoietic_stem1.60008515
34MP0002085_abnormal_embryonic_tissue1.51764801
35MP0003786_premature_aging1.50759874
36MP0002019_abnormal_tumor_incidence1.49002038
37MP0005076_abnormal_cell_differentiation1.47104464
38MP0003453_abnormal_keratinocyte_physiol1.44009303
39MP0000313_abnormal_cell_death1.39233254
40MP0003567_abnormal_fetal_cardiomyocyte1.38685562
41MP0005623_abnormal_meninges_morphology1.35077678
42MP0009333_abnormal_splenocyte_physiolog1.34105803
43MP0005397_hematopoietic_system_phenotyp1.28807408
44MP0001545_abnormal_hematopoietic_system1.28807408
45MP0001348_abnormal_lacrimal_gland1.28531185
46MP0002060_abnormal_skin_morphology1.24711652
47MP0009697_abnormal_copulation1.23347226
48MP0002006_tumorigenesis1.22244916
49MP0008877_abnormal_DNA_methylation1.21283427
50MP0003941_abnormal_skin_development1.21082706
51MP0003763_abnormal_thymus_physiology1.20733183
52MP0001216_abnormal_epidermal_layer1.18120829
53MP0003718_maternal_effect1.14546593
54MP0000537_abnormal_urethra_morphology1.14180777
55MP0000579_abnormal_nail_morphology1.13530822
56MP0005023_abnormal_wound_healing1.13469245
57MP0000703_abnormal_thymus_morphology1.12640401
58MP0010234_abnormal_vibrissa_follicle1.12505134
59MP0000358_abnormal_cell_content/1.11857464
60MP0001293_anophthalmia1.11180897
61MP0003566_abnormal_cell_adhesion1.10809758
62MP0006054_spinal_hemorrhage1.09332793
63MP0002722_abnormal_immune_system1.08188651
64MP0000003_abnormal_adipose_tissue1.06547199
65MP0009840_abnormal_foam_cell1.05800899
66MP0002398_abnormal_bone_marrow1.05699030
67MP0000689_abnormal_spleen_morphology1.02568268
68MP0001915_intracranial_hemorrhage0.95869035
69MP0009672_abnormal_birth_weight0.95116372
70MP0003091_abnormal_cell_migration0.94285228
71MP0001727_abnormal_embryo_implantation0.93706754
72MP0009053_abnormal_anal_canal0.93481678
73MP0002210_abnormal_sex_determination0.92853835
74MP0003221_abnormal_cardiomyocyte_apopto0.92638099
75MP0001145_abnormal_male_reproductive0.91774294
76MP0003890_abnormal_embryonic-extraembry0.88910225
77MP0000627_abnormal_mammary_gland0.88642444
78MP0006035_abnormal_mitochondrial_morpho0.87129081
79MP0000477_abnormal_intestine_morphology0.86386100
80MP0003315_abnormal_perineum_morphology0.85399984
81MP0001849_ear_inflammation0.85267550
82MP0004947_skin_inflammation0.82929149
83MP0005666_abnormal_adipose_tissue0.82709273
84MP0002429_abnormal_blood_cell0.82211902
85MP0005058_abnormal_lysosome_morphology0.80872975
86MP0000678_abnormal_parathyroid_gland0.80569591
87MP0004264_abnormal_extraembryonic_tissu0.80339712
88MP0001929_abnormal_gametogenesis0.80296508
89MP0000858_altered_metastatic_potential0.79973140
90MP0005384_cellular_phenotype0.78869442
91MP0000598_abnormal_liver_morphology0.78761610
92MP0005501_abnormal_skin_physiology0.78715009
93MP0003186_abnormal_redox_activity0.78550597
94MP0004782_abnormal_surfactant_physiolog0.77785687
95MP0002877_abnormal_melanocyte_morpholog0.77291748
96MP0005375_adipose_tissue_phenotype0.76532357
97MP0005621_abnormal_cell_physiology0.76127381
98MP0010678_abnormal_skin_adnexa0.76033153
99MP0002111_abnormal_tail_morphology0.75267746
100MP0010630_abnormal_cardiac_muscle0.74942935
101MP0001881_abnormal_mammary_gland0.74924797
102MP0001873_stomach_inflammation0.74174210
103MP0002092_abnormal_eye_morphology0.73836624
104MP0003119_abnormal_digestive_system0.73399184
105MP0004272_abnormal_basement_membrane0.73050523
106MP0000653_abnormal_sex_gland0.72966633
107MP0009931_abnormal_skin_appearance0.72962974
108MP0000371_diluted_coat_color0.72636155
109MP0004185_abnormal_adipocyte_glucose0.71430308
110MP0009278_abnormal_bone_marrow0.71252906
111MP0002160_abnormal_reproductive_system0.70000787
112MP0008770_decreased_survivor_rate0.69334904
113MP0000747_muscle_weakness0.68111498
114MP0010030_abnormal_orbit_morphology0.67713288
115MP0002139_abnormal_hepatobiliary_system0.66945823
116MP0008438_abnormal_cutaneous_collagen0.66648751
117MP0004087_abnormal_muscle_fiber0.65874999
118MP0003115_abnormal_respiratory_system0.65850911
119MP0000762_abnormal_tongue_morphology0.65724012
120MP0002098_abnormal_vibrissa_morphology0.65463877
121MP0001853_heart_inflammation0.64669295
122MP0000759_abnormal_skeletal_muscle0.64494443
123MP0000716_abnormal_immune_system0.64228978
124MP0009703_decreased_birth_body0.62790436
125MP0003656_abnormal_erythrocyte_physiolo0.62702039
126MP0003121_genomic_imprinting0.60587358
127MP0003300_gastrointestinal_ulcer0.59957075
128MP0000733_abnormal_muscle_development0.59754688
129MP0005266_abnormal_metabolism0.58689879
130MP0002166_altered_tumor_susceptibility0.57413982
131MP0000428_abnormal_craniofacial_morphol0.56592506
132MP0002269_muscular_atrophy0.56554737
133MP0000685_abnormal_immune_system0.56486930
134MP0000609_abnormal_liver_physiology0.56370938
135MP0004233_abnormal_muscle_weight0.56174102
136MP0001243_abnormal_dermal_layer0.55528953
137MP0002697_abnormal_eye_size0.54540387
138MP0005389_reproductive_system_phenotype0.54362657
139MP0000377_abnormal_hair_follicle0.54043667

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.34764834
2Birth length less than 3rd percentile (HP:0003561)4.17818768
3Reticulocytopenia (HP:0001896)4.13980954
4Ependymoma (HP:0002888)4.04474631
5Abnormal number of erythroid precursors (HP:0012131)4.01871160
6Oral leukoplakia (HP:0002745)3.71459577
7Selective tooth agenesis (HP:0001592)3.55778206
8Colon cancer (HP:0003003)3.47604194
9Hyperacusis (HP:0010780)3.45745446
10Breast hypoplasia (HP:0003187)3.25775263
11Medulloblastoma (HP:0002885)3.24317676
12Degeneration of anterior horn cells (HP:0002398)3.13988848
13Abnormality of the anterior horn cell (HP:0006802)3.13988848
14Basal cell carcinoma (HP:0002671)3.13290881
15Microvesicular hepatic steatosis (HP:0001414)3.09297883
16Rhabdomyosarcoma (HP:0002859)3.04375385
17Macrocytic anemia (HP:0001972)2.96989981
18Ankyloglossia (HP:0010296)2.92397505
19Agnosia (HP:0010524)2.89408471
20Progressive external ophthalmoplegia (HP:0000590)2.76473078
21Pallor (HP:0000980)2.76376999
22Abnormality of oral frenula (HP:0000190)2.71766213
23Aplastic anemia (HP:0001915)2.71588963
24Ragged-red muscle fibers (HP:0003200)2.69774180
25Multiple enchondromatosis (HP:0005701)2.68093637
26Abnormality of pyrimidine metabolism (HP:0004353)2.64368262
27Thrombocytosis (HP:0001894)2.62328510
28Rough bone trabeculation (HP:0100670)2.60193155
29Deep philtrum (HP:0002002)2.60036999
30Abnormality of the astrocytes (HP:0100707)2.59208964
31Astrocytoma (HP:0009592)2.59208964
32Trismus (HP:0000211)2.56712695
33Asymmetry of the thorax (HP:0001555)2.56656434
34Neoplasm of the pancreas (HP:0002894)2.56290014
35Absent thumb (HP:0009777)2.55338164
36Termporal pattern (HP:0011008)2.53700812
37Insidious onset (HP:0003587)2.53700812
38Spastic diplegia (HP:0001264)2.52510224
39Impulsivity (HP:0100710)2.50149205
40Abnormality of chromosome stability (HP:0003220)2.49500736
41Squamous cell carcinoma (HP:0002860)2.47670429
42Distal lower limb amyotrophy (HP:0008944)2.46227881
43Insomnia (HP:0100785)2.44476610
44Abnormality of reticulocytes (HP:0004312)2.42849101
45Dysmetric saccades (HP:0000641)2.42812430
46Chromsome breakage (HP:0040012)2.42487354
47Proximal placement of thumb (HP:0009623)2.41388272
48Microretrognathia (HP:0000308)2.35935365
49Neoplasm of striated muscle (HP:0009728)2.35340683
50Deviation of the thumb (HP:0009603)2.34529747
51Progressive muscle weakness (HP:0003323)2.34500368
52Myelodysplasia (HP:0002863)2.34150618
53Patellar aplasia (HP:0006443)2.32032581
54Short nail (HP:0001799)2.31779029
55Biliary tract neoplasm (HP:0100574)2.31357989
56Cerebral hypomyelination (HP:0006808)2.30073888
57Adenoma sebaceum (HP:0009720)2.27586970
58Angiofibromas (HP:0010615)2.27586970
59Amaurosis fugax (HP:0100576)2.27517056
60Glioma (HP:0009733)2.23961957
61Carpal bone hypoplasia (HP:0001498)2.22878639
6211 pairs of ribs (HP:0000878)2.22772832
63Missing ribs (HP:0000921)2.22204141
64Aplasia/Hypoplasia of the patella (HP:0006498)2.19278735
65Abnormality of the preputium (HP:0100587)2.18986421
66Premature graying of hair (HP:0002216)2.18400293
67Ulnar bowing (HP:0003031)2.17631843
68Increased connective tissue (HP:0009025)2.15210491
69Orthostatic hypotension (HP:0001278)2.14213161
70Megaloblastic anemia (HP:0001889)2.13640881
71Overlapping toe (HP:0001845)2.13431627
72Abnormality of the labia minora (HP:0012880)2.12156673
73Abnormality of the calcaneus (HP:0008364)2.11595766
74Chromosomal breakage induced by crosslinking agents (HP:0003221)2.10173736
75Centrally nucleated skeletal muscle fibers (HP:0003687)2.09937001
76Atrophy/Degeneration involving motor neurons (HP:0007373)2.09756493
77Long palpebral fissure (HP:0000637)2.09184497
78Premature rupture of membranes (HP:0001788)2.07153735
79Neoplasm of the oral cavity (HP:0100649)2.06366510
80Absent radius (HP:0003974)2.05567600
81Entropion (HP:0000621)2.04588101
82Meckel diverticulum (HP:0002245)2.03616524
83Vertebral compression fractures (HP:0002953)2.03238621
84Abnormality of the distal phalanges of the toes (HP:0010182)2.03168395
85Abnormality of glycolysis (HP:0004366)2.02688005
86High pitched voice (HP:0001620)2.01570887
87Fatigue (HP:0012378)2.01086979
88Premature ovarian failure (HP:0008209)2.00682117
89Pelvic girdle muscle weakness (HP:0003749)2.00387635
90Back pain (HP:0003418)1.98680663
91Poikiloderma (HP:0001029)1.97965709
92Overriding aorta (HP:0002623)1.96772063
93Cutaneous melanoma (HP:0012056)1.96771819
94Atresia of the external auditory canal (HP:0000413)1.96662905
95Septate vagina (HP:0001153)1.96515632
96Abnormality of the ileum (HP:0001549)1.96486280
97Cortical dysplasia (HP:0002539)1.96480465
98Elbow flexion contracture (HP:0002987)1.95724090
99Cafe-au-lait spot (HP:0000957)1.95506513
100Deep palmar crease (HP:0006191)1.94539256
101Osteolytic defects of the phalanges of the hand (HP:0009771)1.92752604
102Osteolytic defects of the hand bones (HP:0009699)1.92752604
103Syringomyelia (HP:0003396)1.91410954
104Spinal cord lesions (HP:0100561)1.91410954
105Hypobetalipoproteinemia (HP:0003563)1.90208838
106Relative macrocephaly (HP:0004482)1.88007130
107Abnormal number of incisors (HP:0011064)1.87680209
108Ridged nail (HP:0001807)1.86322015
109Absent forearm bone (HP:0003953)1.86003977
110Aplasia involving forearm bones (HP:0009822)1.86003977
111Elfin facies (HP:0004428)1.85616889
112Increased nuchal translucency (HP:0010880)1.85087613
113Patellar dislocation (HP:0002999)1.84913987
114Glossoptosis (HP:0000162)1.84638260
115Aplasia/Hypoplasia of the uvula (HP:0010293)1.83934842
116Subacute progressive viral hepatitis (HP:0006572)1.83337856
117Bone marrow hypocellularity (HP:0005528)1.83334530
118Cellular immunodeficiency (HP:0005374)1.82289971
119Slender long bone (HP:0003100)1.81737797
120Flat acetabular roof (HP:0003180)1.79317780
121Supernumerary spleens (HP:0009799)1.79302003
122Shoulder girdle muscle weakness (HP:0003547)1.78992225
123Micronodular cirrhosis (HP:0001413)1.78865963
124Facial hemangioma (HP:0000329)1.78811966
125Neoplasm of the colon (HP:0100273)1.78153327
126Duodenal stenosis (HP:0100867)1.77901294
127Small intestinal stenosis (HP:0012848)1.77901294
128Personality changes (HP:0000751)1.77849294
129Abnormality of monocarboxylic acid metabolism (HP:0010996)1.77583561
130Horseshoe kidney (HP:0000085)1.77341485
131Abnormal trabecular bone morphology (HP:0100671)1.76561976
132Freckling (HP:0001480)1.75443825
133Ovarian neoplasm (HP:0100615)1.74021562
134IgM deficiency (HP:0002850)1.73029061
135Natal tooth (HP:0000695)1.72631015
136Renal duplication (HP:0000075)1.72401643
137Increased density of long bones (HP:0006392)1.72397976
138Tracheoesophageal fistula (HP:0002575)1.71439083
139Broad face (HP:0000283)1.70700861
140Unilateral renal agenesis (HP:0000122)1.70005105
141Progressive hearing impairment (HP:0001730)1.69249737
142Urethral obstruction (HP:0000796)1.69019923
143Abnormality of the umbilical cord (HP:0010881)1.68773494
144Ureteral duplication (HP:0000073)1.67818424
145Neoplasm of the rectum (HP:0100743)1.67693962
146Reticulocytosis (HP:0001923)1.67525580
147Heterotopia (HP:0002282)1.67348215
148Secondary amenorrhea (HP:0000869)1.67201113
149Ankle contracture (HP:0006466)1.67124852
150Aplasia cutis congenita (HP:0001057)1.66756317
151Lower limb amyotrophy (HP:0007210)1.66024048
152Aplasia/hypoplasia of the humerus (HP:0006507)1.65851129
153Pseudobulbar signs (HP:0002200)1.65575602
154Increased serum pyruvate (HP:0003542)1.64809100
155Pancytopenia (HP:0001876)1.64557481
156Abnormality of pain sensation (HP:0010832)1.63960081
157Impaired pain sensation (HP:0007328)1.63960081
158Reduced subcutaneous adipose tissue (HP:0003758)1.63066095
159Abnormality of the salivary glands (HP:0010286)1.62078930
160* Prominent nose (HP:0000448)1.61158972
161Viral hepatitis (HP:0006562)1.60926846
162Long eyelashes (HP:0000527)1.60751308
163Calcaneovalgus deformity (HP:0001848)1.60108143
164Abnormal gallbladder physiology (HP:0012438)1.57259571
165Cholecystitis (HP:0001082)1.57259571
166Dislocated radial head (HP:0003083)1.57232451
167Autoamputation (HP:0001218)1.56705641
168Advanced eruption of teeth (HP:0006288)1.54202331
169Pointed chin (HP:0000307)1.53432219
170Abnormalities of placenta or umbilical cord (HP:0001194)1.49560443

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.02556981
2CDC73.73351666
3BUB13.52023143
4SMG13.17101244
5EEF2K3.03288573
6EIF2AK12.87822213
7IRAK32.80419586
8NEK22.68262641
9MST1R2.67537046
10PKN22.59930828
11SCYL22.33048400
12ICK2.29592896
13TSSK62.29313415
14NME22.22889476
15NEK12.15955411
16RPS6KB22.12942324
17TESK22.08721833
18PBK2.06599919
19TTK2.05810946
20PASK2.00825024
21PRPF4B1.91436518
22CDK121.79074476
23SRPK11.77181629
24BRSK21.72383385
25ACVR1B1.71284206
26FLT31.68324350
27EPHA21.64155186
28TRIB31.62906957
29PLK11.58782783
30MAP3K81.58500013
31MAP3K101.54827374
32RPS6KA41.54236110
33CDK71.53172416
34CDK41.50141532
35EIF2AK31.49394256
36TLK11.45741850
37ATR1.45085944
38STK101.43630666
39TGFBR11.39536331
40DYRK31.34243832
41* AURKB1.33341352
42ALK1.30002343
43MAP4K11.29794172
44MAP3K141.25556252
45CHEK11.19302309
46MKNK11.17367238
47LRRK21.15840572
48FGFR41.11064321
49PAK41.10542425
50CHEK21.09402547
51AURKA1.07505741
52MAP2K31.06972425
53PLK31.05174011
54MAP3K111.03318584
55ERBB41.01304286
56MAPKAPK30.99816159
57TESK10.98424524
58SIK10.97517805
59BCKDK0.97358082
60PDGFRA0.97187904
61PLK40.94583439
62VRK10.91220500
63TAF10.90631773
64CDK80.90417317
65PIM10.90341798
66BRAF0.88151700
67CLK10.87825046
68CDK60.85805463
69PDK40.85581440
70PDK30.85581440
71BRSK10.84635532
72KDR0.83647928
73KSR20.83108612
74PIM20.81589509
75MAP3K130.79720818
76IRAK40.79429298
77CDK20.79358133
78CAMK1D0.76941220
79ZAP700.76152799
80MKNK20.75491166
81ATM0.75166818
82MTOR0.73731850
83PAK20.71819874
84CSNK2A20.71071677
85PTK20.71037849
86STK40.68469936
87STK160.65974393
88TTN0.60745031
89PAK10.59717658
90CDK90.58459469
91ARAF0.57437822
92PNCK0.57092738
93JAK30.57045713
94IRAK20.56385281
95GRK60.55649333
96STK30.55627988
97MAP3K90.53251402
98BRD40.52630847
99CAMK1G0.50095292
100ILK0.49567264
101AKT20.48366666
102CSNK1E0.48261111
103CSNK2A10.48115812
104CDK10.47746222
105MAP3K30.45417511
106EIF2AK20.44732502
107MELK0.44112980
108FGFR10.41964962
109PRKCI0.41658789
110BTK0.40641493
111PTK60.40180674
112RAF10.40060448
113RIPK10.39123150
114LATS20.38472853
115SIK30.37949778
116NEK60.37538326
117BMX0.36889320
118MAPK110.35343624
119NME10.34705876
120ERN10.34420163
121MAP2K20.33883065
122TAOK20.33258936
123MAP3K50.33164659
124RPS6KA50.32833580
125KSR10.32582334
126CSF1R0.31880186
127PRKDC0.31043883
128MET0.30260714
129CSNK1D0.29449327
130LATS10.28921953
131BLK0.25353580
132PDK20.25035892
133NEK90.24890159
134TAOK10.23416283

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.63652962
2Mismatch repair_Homo sapiens_hsa034303.79750777
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.78544717
4One carbon pool by folate_Homo sapiens_hsa006703.47155617
5RNA transport_Homo sapiens_hsa030133.19641448
6Ribosome_Homo sapiens_hsa030103.10816538
7Spliceosome_Homo sapiens_hsa030403.03869772
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.98777195
9Base excision repair_Homo sapiens_hsa034102.60057058
10Nucleotide excision repair_Homo sapiens_hsa034202.53313847
11Proteasome_Homo sapiens_hsa030502.47967488
12RNA polymerase_Homo sapiens_hsa030202.42500947
13Cell cycle_Homo sapiens_hsa041102.38313486
14Homologous recombination_Homo sapiens_hsa034402.28135088
15Pyrimidine metabolism_Homo sapiens_hsa002402.12456534
16Selenocompound metabolism_Homo sapiens_hsa004501.62890583
17Non-homologous end-joining_Homo sapiens_hsa034501.62888459
18Biosynthesis of amino acids_Homo sapiens_hsa012301.60830729
19RNA degradation_Homo sapiens_hsa030181.58513029
20mRNA surveillance pathway_Homo sapiens_hsa030151.58053932
21Fanconi anemia pathway_Homo sapiens_hsa034601.54389781
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.47988814
23p53 signaling pathway_Homo sapiens_hsa041151.45702863
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.44840026
25Systemic lupus erythematosus_Homo sapiens_hsa053221.43635421
26Sulfur relay system_Homo sapiens_hsa041221.39837495
27Pancreatic cancer_Homo sapiens_hsa052121.39508260
28Pentose phosphate pathway_Homo sapiens_hsa000301.38318629
29Folate biosynthesis_Homo sapiens_hsa007901.24434824
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.23535332
31Basal transcription factors_Homo sapiens_hsa030221.21903547
32Antigen processing and presentation_Homo sapiens_hsa046121.11680269
33Viral carcinogenesis_Homo sapiens_hsa052031.10756573
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09165582
35Carbon metabolism_Homo sapiens_hsa012001.08184255
36Vitamin B6 metabolism_Homo sapiens_hsa007501.05042694
37Epstein-Barr virus infection_Homo sapiens_hsa051691.01191688
38Purine metabolism_Homo sapiens_hsa002300.97635527
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95884136
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92207453
41Prostate cancer_Homo sapiens_hsa052150.92060143
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90883311
43Endometrial cancer_Homo sapiens_hsa052130.90154995
44Adherens junction_Homo sapiens_hsa045200.86120853
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84049666
46Renal cell carcinoma_Homo sapiens_hsa052110.83664963
47Herpes simplex infection_Homo sapiens_hsa051680.81069676
48Thyroid cancer_Homo sapiens_hsa052160.79202083
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77284230
50Other glycan degradation_Homo sapiens_hsa005110.75740245
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73844877
52Glioma_Homo sapiens_hsa052140.72565812
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71716799
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69465270
55Proteoglycans in cancer_Homo sapiens_hsa052050.69087050
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.68860463
57B cell receptor signaling pathway_Homo sapiens_hsa046620.68849645
58Oocyte meiosis_Homo sapiens_hsa041140.68197024
59HTLV-I infection_Homo sapiens_hsa051660.68046111
60Insulin signaling pathway_Homo sapiens_hsa049100.67113525
61VEGF signaling pathway_Homo sapiens_hsa043700.66657406
62Small cell lung cancer_Homo sapiens_hsa052220.66585056
63Legionellosis_Homo sapiens_hsa051340.64738972
64ErbB signaling pathway_Homo sapiens_hsa040120.63726714
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63487376
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63384393
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60561763
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60307935
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59807560
70Hepatitis C_Homo sapiens_hsa051600.59532222
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59403582
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59384504
73MicroRNAs in cancer_Homo sapiens_hsa052060.57211338
74Prion diseases_Homo sapiens_hsa050200.57064895
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56587540
76Glutathione metabolism_Homo sapiens_hsa004800.56279388
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56008635
78Bladder cancer_Homo sapiens_hsa052190.52470251
79Fructose and mannose metabolism_Homo sapiens_hsa000510.51429761
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46794579
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45701669
82Chronic myeloid leukemia_Homo sapiens_hsa052200.45538837
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.45182884
84Galactose metabolism_Homo sapiens_hsa000520.44777055
85Prolactin signaling pathway_Homo sapiens_hsa049170.44479535
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44014001
87Apoptosis_Homo sapiens_hsa042100.43772803
88AMPK signaling pathway_Homo sapiens_hsa041520.42127469
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42107751
90Primary immunodeficiency_Homo sapiens_hsa053400.41332330
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40700739
92N-Glycan biosynthesis_Homo sapiens_hsa005100.39523658
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38601086
94Focal adhesion_Homo sapiens_hsa045100.38579425
95Pyruvate metabolism_Homo sapiens_hsa006200.37170066
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36329922
97Arginine and proline metabolism_Homo sapiens_hsa003300.35798915
98Acute myeloid leukemia_Homo sapiens_hsa052210.35471531
99Lysine degradation_Homo sapiens_hsa003100.35203199
100Alcoholism_Homo sapiens_hsa050340.35071532
101Toxoplasmosis_Homo sapiens_hsa051450.34639882
102Shigellosis_Homo sapiens_hsa051310.34572863
103TNF signaling pathway_Homo sapiens_hsa046680.34416917
104HIF-1 signaling pathway_Homo sapiens_hsa040660.34092302
105Nitrogen metabolism_Homo sapiens_hsa009100.32910471
106Hepatitis B_Homo sapiens_hsa051610.32080994
107mTOR signaling pathway_Homo sapiens_hsa041500.31736709
108Colorectal cancer_Homo sapiens_hsa052100.30064866
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29762660
110Measles_Homo sapiens_hsa051620.29011843
111Arginine biosynthesis_Homo sapiens_hsa002200.28055717
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25601113
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23842021
114Caffeine metabolism_Homo sapiens_hsa002320.20746337
115TGF-beta signaling pathway_Homo sapiens_hsa043500.19513077
116Hippo signaling pathway_Homo sapiens_hsa043900.19371873
117NF-kappa B signaling pathway_Homo sapiens_hsa040640.18081344
118Metabolic pathways_Homo sapiens_hsa011000.16851399
119Non-small cell lung cancer_Homo sapiens_hsa052230.16008621
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.14801566
121Notch signaling pathway_Homo sapiens_hsa043300.12916061
122Renin-angiotensin system_Homo sapiens_hsa046140.12449467
123Viral myocarditis_Homo sapiens_hsa054160.11413142
124Influenza A_Homo sapiens_hsa051640.11251671
125Fat digestion and absorption_Homo sapiens_hsa049750.09907635
126Pathways in cancer_Homo sapiens_hsa052000.07244181
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.06126431

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