NSUN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of B cell differentiation (GO:0045579)4.89712850
2DNA deamination (GO:0045006)4.73500544
3protein K11-linked deubiquitination (GO:0035871)4.70712205
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.57717286
5neural tube formation (GO:0001841)4.19328724
6histamine secretion (GO:0001821)4.17696763
7positive regulation of gamma-delta T cell activation (GO:0046645)3.95035447
8regulation of B cell differentiation (GO:0045577)3.93649730
9regulation of B cell receptor signaling pathway (GO:0050855)3.86265456
10defense response to protozoan (GO:0042832)3.79206994
11histamine transport (GO:0051608)3.76360014
12polyketide metabolic process (GO:0030638)3.46059856
13doxorubicin metabolic process (GO:0044598)3.46059856
14daunorubicin metabolic process (GO:0044597)3.46059856
15regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.45891544
16histone mRNA catabolic process (GO:0071044)3.42062292
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.36697413
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.36697413
19hepatocyte apoptotic process (GO:0097284)3.34362087
20immunoglobulin mediated immune response (GO:0016064)3.31223936
21negative regulation of translation, ncRNA-mediated (GO:0040033)3.30101162
22regulation of translation, ncRNA-mediated (GO:0045974)3.30101162
23negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.30101162
24negative regulation of phagocytosis (GO:0050765)3.30050484
25cellular response to exogenous dsRNA (GO:0071360)3.29091713
26antigen processing and presentation of endogenous antigen (GO:0019883)3.27331434
27response to protozoan (GO:0001562)3.26633533
28positive regulation of interferon-alpha production (GO:0032727)3.23690127
29response to pheromone (GO:0019236)3.22383057
30modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.19735319
31positive regulation by organism of defense response of other organism involved in symbiotic interact3.19735319
32modulation by symbiont of host immune response (GO:0052553)3.19735319
33positive regulation by symbiont of host defense response (GO:0052509)3.19735319
34modulation by symbiont of host defense response (GO:0052031)3.19735319
35modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.19735319
36activated T cell proliferation (GO:0050798)3.18449779
37RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.17630163
38interferon-gamma production (GO:0032609)3.17175488
39DNA demethylation (GO:0080111)3.10490009
40positive regulation of chemokine biosynthetic process (GO:0045080)3.08173592
41regulation of chemokine biosynthetic process (GO:0045073)3.06896993
42regulation of interferon-alpha production (GO:0032647)3.03681506
43L-fucose catabolic process (GO:0042355)3.02193966
44fucose catabolic process (GO:0019317)3.02193966
45L-fucose metabolic process (GO:0042354)3.02193966
46negative regulation of growth of symbiont in host (GO:0044130)3.01524158
47negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.01524158
48modulation of growth of symbiont involved in interaction with host (GO:0044144)3.01524158
49regulation of growth of symbiont in host (GO:0044126)3.01524158
50regulation of interferon-beta biosynthetic process (GO:0045357)2.99590470
51gonadal mesoderm development (GO:0007506)2.98700620
52preassembly of GPI anchor in ER membrane (GO:0016254)2.96469058
53indolalkylamine metabolic process (GO:0006586)2.92467697
54myeloid dendritic cell activation (GO:0001773)2.92325954
55DNA double-strand break processing (GO:0000729)2.89415371
56indole-containing compound catabolic process (GO:0042436)2.88789104
57indolalkylamine catabolic process (GO:0046218)2.88789104
58tryptophan catabolic process (GO:0006569)2.88789104
59regulation of regulatory T cell differentiation (GO:0045589)2.87543041
60regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.87085502
61nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.86961305
62B cell receptor signaling pathway (GO:0050853)2.86743542
63prenylation (GO:0097354)2.86647725
64protein prenylation (GO:0018342)2.86647725
65attachment of spindle microtubules to kinetochore (GO:0008608)2.86647527
66response to xenobiotic stimulus (GO:0009410)2.86020397
67behavioral response to nicotine (GO:0035095)2.83447710
68exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.82762180
69regulation of interleukin-12 biosynthetic process (GO:0045075)2.82756074
70microglial cell activation (GO:0001774)2.82267119
71definitive hemopoiesis (GO:0060216)2.81713340
72respiratory burst (GO:0045730)2.80525279
73B cell mediated immunity (GO:0019724)2.80159042
74neutrophil activation involved in immune response (GO:0002283)2.75646299
75respiratory chain complex IV assembly (GO:0008535)2.73672196
76positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.73487351
77tryptophan metabolic process (GO:0006568)2.73204074
78positive regulation of natural killer cell differentiation (GO:0032825)2.73074511
79phenylpropanoid metabolic process (GO:0009698)2.72950034
80CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.72404762
81cellular response to interleukin-15 (GO:0071350)2.67997667
82histone mRNA metabolic process (GO:0008334)2.67331101
83protein complex biogenesis (GO:0070271)2.67302217
84leukocyte aggregation (GO:0070486)2.67003404
85Arp2/3 complex-mediated actin nucleation (GO:0034314)2.66959061
86water-soluble vitamin biosynthetic process (GO:0042364)2.65533047
87valine metabolic process (GO:0006573)2.64983403
88reactive oxygen species biosynthetic process (GO:1903409)2.64148326
89cytochrome complex assembly (GO:0017004)2.64017901
90cellular response to interferon-beta (GO:0035458)2.63462378
91platelet dense granule organization (GO:0060155)2.62812503
92lymphoid progenitor cell differentiation (GO:0002320)2.61861446
93protoporphyrinogen IX biosynthetic process (GO:0006782)2.61339328
94regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.60801318
95dopamine transport (GO:0015872)2.58611077
96positive regulation of T cell mediated cytotoxicity (GO:0001916)2.57875699
97oligosaccharide catabolic process (GO:0009313)2.57421299
98detection of other organism (GO:0098543)2.56846216
99I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.56276824
100protein localization to cilium (GO:0061512)2.55995057
101rRNA catabolic process (GO:0016075)2.54923498
102centriole replication (GO:0007099)2.54660994
103mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.54170355
104mitochondrial respiratory chain complex I assembly (GO:0032981)2.54170355
105NADH dehydrogenase complex assembly (GO:0010257)2.54170355
106pyrimidine ribonucleoside catabolic process (GO:0046133)2.53870687
107organelle disassembly (GO:1903008)2.53590109
108amine catabolic process (GO:0009310)2.53410216
109cellular biogenic amine catabolic process (GO:0042402)2.53410216
110regulation of RIG-I signaling pathway (GO:0039535)2.52948041
111mannosylation (GO:0097502)2.52803687
112mitochondrial respiratory chain complex assembly (GO:0033108)2.52398025
113RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.51947277
114tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.51947277
115protoporphyrinogen IX metabolic process (GO:0046501)2.51134861
116cytidine deamination (GO:0009972)2.50995785
117cytidine metabolic process (GO:0046087)2.50995785
118cytidine catabolic process (GO:0006216)2.50995785
119negative regulation of DNA-dependent DNA replication (GO:2000104)2.50096379
120positive regulation of granulocyte differentiation (GO:0030854)2.50050966
121response to host immune response (GO:0052572)2.49884773
122response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.49884773
123response to type I interferon (GO:0034340)2.49659328
124protein K63-linked deubiquitination (GO:0070536)2.49378171
125cellular response to type I interferon (GO:0071357)2.48272851
126type I interferon signaling pathway (GO:0060337)2.48272851
127DNA topological change (GO:0006265)2.46006953
128killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.45271219
129disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.45271219
130regulation of response to interferon-gamma (GO:0060330)2.44740297
131detection of bacterium (GO:0016045)2.43963854
132GPI anchor metabolic process (GO:0006505)2.43079009
133signal peptide processing (GO:0006465)2.42850978
134regulation of gamma-delta T cell activation (GO:0046643)2.41627614
135regulation of memory T cell differentiation (GO:0043380)2.41488890
136DNA dealkylation (GO:0035510)2.41219892
137positive regulation of alpha-beta T cell proliferation (GO:0046641)2.40328661
138T cell lineage commitment (GO:0002360)2.39532881
139regulation of B cell mediated immunity (GO:0002712)2.38640287
140negative regulation of execution phase of apoptosis (GO:1900118)2.38081913
141response to interleukin-15 (GO:0070672)2.37563164
142establishment of protein localization to Golgi (GO:0072600)2.37492645
143nucleotide transmembrane transport (GO:1901679)2.37249447
144T cell migration (GO:0072678)2.36551520
145glycosphingolipid catabolic process (GO:0046479)2.36544023
146negative regulation of telomere maintenance (GO:0032205)2.36450672
147regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.35804039
148regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.35777563
149actin nucleation (GO:0045010)2.35041333
150monoubiquitinated protein deubiquitination (GO:0035520)2.33408374
151negative T cell selection (GO:0043383)2.33045331
152regulation of natural killer cell differentiation (GO:0032823)2.32929570
153recombinational repair (GO:0000725)2.32067616
154neutrophil mediated immunity (GO:0002446)2.32062585
155regulation of B cell apoptotic process (GO:0002902)2.31999295
156transcription elongation from RNA polymerase III promoter (GO:0006385)2.31895091
157termination of RNA polymerase III transcription (GO:0006386)2.31895091
158ceramide catabolic process (GO:0046514)2.31632508
159detection of molecule of bacterial origin (GO:0032490)2.31482705
160somatic hypermutation of immunoglobulin genes (GO:0016446)2.31462624
161somatic diversification of immune receptors via somatic mutation (GO:0002566)2.31462624
162regulation of interleukin-6 biosynthetic process (GO:0045408)2.30797501
163regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.30362575
164kynurenine metabolic process (GO:0070189)2.30041395
165replicative senescence (GO:0090399)2.30004360
166regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.29528687
167regulation of mitotic spindle checkpoint (GO:1903504)2.29528687
168negative regulation of mast cell activation (GO:0033004)2.29131655
169positive regulation of B cell activation (GO:0050871)2.28406642
170double-strand break repair via homologous recombination (GO:0000724)2.28394533
171production of molecular mediator involved in inflammatory response (GO:0002532)2.27947460
172negative regulation of B cell proliferation (GO:0030889)2.27511845
173somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.27386919
174somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.27386919
175isotype switching (GO:0045190)2.27386919
176regulation of isotype switching to IgG isotypes (GO:0048302)2.27209740
177positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.26646472
178response to hydroperoxide (GO:0033194)2.26404655
179purine-containing compound salvage (GO:0043101)2.25691496
180response to host (GO:0075136)2.25559455
181response to host defenses (GO:0052200)2.25559455
182response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.25559455
183detection of external biotic stimulus (GO:0098581)2.25221616
184regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.25089599
185positive regulation of interferon-gamma production (GO:0032729)2.24288390
186positive regulation of defense response to virus by host (GO:0002230)2.23903500

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.33215537
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.69124730
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.43247189
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.12577590
5GATA1_22025678_ChIP-Seq_K562_Human3.32437620
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.27638998
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.15304345
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.05842453
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.02546493
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.94295913
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.82641859
12ZNF274_21170338_ChIP-Seq_K562_Hela2.79287331
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.59969771
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.55389350
15VDR_22108803_ChIP-Seq_LS180_Human2.49763580
16SCL_19346495_ChIP-Seq_HPC-7_Human2.45895176
17* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.30636295
18TAF15_26573619_Chip-Seq_HEK293_Human2.19862032
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.19658767
20EGR1_23403033_ChIP-Seq_LIVER_Mouse2.16102187
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15938676
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.15720834
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.11319150
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.11069788
25* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08641591
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07451923
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.00675466
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.00570299
29EWS_26573619_Chip-Seq_HEK293_Human2.00536454
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.98532258
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.98269367
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.93966621
33SPI1_23547873_ChIP-Seq_NB4_Human1.91397974
34GBX2_23144817_ChIP-Seq_PC3_Human1.88718951
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.88629467
36* FUS_26573619_Chip-Seq_HEK293_Human1.86815481
37STAT4_19710469_ChIP-ChIP_TH1__Mouse1.85620210
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80529694
39ER_23166858_ChIP-Seq_MCF-7_Human1.80413512
40CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.79381303
41RUNX_20019798_ChIP-Seq_JUKART_Human1.79303091
42P300_19829295_ChIP-Seq_ESCs_Human1.75086636
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.71173066
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70001815
45MYB_26560356_Chip-Seq_TH2_Human1.68994970
46* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68465109
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.67309333
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.67209576
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62916272
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.62103478
51ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.60320634
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.59876426
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.59632782
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.59413622
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.58273993
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.58140146
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57664600
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54684590
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.54033978
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.53774231
61* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53773340
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51951839
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.48799279
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47294051
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.46779317
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45087265
67FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.44826527
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44671978
69CBP_20019798_ChIP-Seq_JUKART_Human1.41492447
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41492447
71RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40557765
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.37873624
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36949552
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.36133965
75MYB_26560356_Chip-Seq_TH1_Human1.35617837
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.34568840
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33684139
78CRX_20693478_ChIP-Seq_RETINA_Mouse1.32891299
79BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32124263
80SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32022832
81E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31918841
82* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30306111
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30236337
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30109545
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29211744
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27489470
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26733565
88P53_22387025_ChIP-Seq_ESCs_Mouse1.26626680
89TP53_22573176_ChIP-Seq_HFKS_Human1.26237417
90EGR1_19374776_ChIP-ChIP_THP-1_Human1.24898174
91PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23508877
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23322891
93BCAT_22108803_ChIP-Seq_LS180_Human1.22370405
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22258463
95SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.22213080
96GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21713360
97IGF1R_20145208_ChIP-Seq_DFB_Human1.21642298
98STAT3_23295773_ChIP-Seq_U87_Human1.21564852
99STAT3_18555785_Chip-Seq_ESCs_Mouse1.20969727
100PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20082238
101E2F1_18555785_Chip-Seq_ESCs_Mouse1.19885151
102IRF1_19129219_ChIP-ChIP_H3396_Human1.19665784
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.19179182
104RUNX1_22412390_ChIP-Seq_EML_Mouse1.18735599
105NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.18387800
106SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17099040
107CMYC_18555785_Chip-Seq_ESCs_Mouse1.16921034
108MYC_18940864_ChIP-ChIP_HL60_Human1.15971245
109* VDR_23849224_ChIP-Seq_CD4+_Human1.15032618
110PU_27001747_Chip-Seq_BMDM_Mouse1.14771978
111NANOG_19829295_ChIP-Seq_ESCs_Human1.14385214
112SOX2_19829295_ChIP-Seq_ESCs_Human1.14385214
113GATA3_26560356_Chip-Seq_TH2_Human1.14326151
114GABP_17652178_ChIP-ChIP_JURKAT_Human1.14128153
115E2F1_21310950_ChIP-Seq_MCF-7_Human1.13515821
116RXR_22158963_ChIP-Seq_LIVER_Mouse1.12837050
117OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12250393
118* SMAD4_21799915_ChIP-Seq_A2780_Human1.12200612
119AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12123640
120* ELK1_19687146_ChIP-ChIP_HELA_Human1.11023609
121TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10935018
122FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10313445
123P300_18555785_Chip-Seq_ESCs_Mouse1.08885267
124SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08505345
125PIAS1_25552417_ChIP-Seq_VCAP_Human1.07717081
126EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07675778
127ETS1_20019798_ChIP-Seq_JURKAT_Human1.07225521
128PRDM14_20953172_ChIP-Seq_ESCs_Human1.06545401
129CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06121121
130NFE2_27457419_Chip-Seq_LIVER_Mouse1.06012655
131OCT4_18555785_Chip-Seq_ESCs_Mouse1.05885861
132* FLI1_21867929_ChIP-Seq_TH2_Mouse1.05851767
133CDX2_22108803_ChIP-Seq_LS180_Human1.05754279
134POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04204438
135SPI1_23127762_ChIP-Seq_K562_Human1.03402903
136RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02610843
137PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02154136
138KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02078561
139CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.01915274
140GATA3_27048872_Chip-Seq_THYMUS_Human1.01742505
141SALL4_22934838_ChIP-ChIP_CD34+_Human1.01435728
142SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01291788
143ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00721433
144PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98924884
145VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98614224
146PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97641607
147RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97412084
148* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96259810
149FOXP3_21729870_ChIP-Seq_TREG_Human0.95924981
150EST1_17652178_ChIP-ChIP_JURKAT_Human0.95399036
151VDR_24763502_ChIP-Seq_THP-1_Human0.95361697
152EZH2_27294783_Chip-Seq_NPCs_Mouse0.94943042
153CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94463220
154PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94181579
155PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92665091
156* JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.90032018
157GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89741458
158VDR_24787735_ChIP-Seq_THP-1_Human0.89733380
159GATA1_19941827_ChIP-Seq_MEL_Mouse0.88812940
160TP63_19390658_ChIP-ChIP_HaCaT_Human0.88569237
161PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88195724
162* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.86675612
163VDR_21846776_ChIP-Seq_THP-1_Human0.84955794
164CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84837316

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.33622398
2MP0001835_abnormal_antigen_presentation3.88573851
3MP0005671_abnormal_response_to2.81114191
4MP0009785_altered_susceptibility_to2.70143521
5MP0008877_abnormal_DNA_methylation2.69423423
6MP0002396_abnormal_hematopoietic_system2.53898385
7MP0003787_abnormal_imprinting2.48757739
8MP0003656_abnormal_erythrocyte_physiolo2.44900069
9MP0004147_increased_porphyrin_level2.40812237
10MP0002139_abnormal_hepatobiliary_system2.34157903
11MP0005360_urolithiasis2.29308919
12MP0001800_abnormal_humoral_immune2.27907050
13MP0002419_abnormal_innate_immunity2.26953938
14MP0005387_immune_system_phenotype2.21860415
15MP0001790_abnormal_immune_system2.21860415
16MP0003436_decreased_susceptibility_to2.21754274
17MP0003195_calcinosis2.20918489
18MP0002452_abnormal_antigen_presenting2.18129519
19MP0005464_abnormal_platelet_physiology2.17661363
20MP0009697_abnormal_copulation2.17279639
21MP0005365_abnormal_bile_salt2.09987216
22MP0005025_abnormal_response_to2.09648049
23MP0005000_abnormal_immune_tolerance2.08220807
24MP0002723_abnormal_immune_serum2.02460507
25MP0002420_abnormal_adaptive_immunity1.94522767
26MP0001819_abnormal_immune_cell1.94433646
27MP0003763_abnormal_thymus_physiology1.86520666
28MP0000685_abnormal_immune_system1.86412027
29MP0003183_abnormal_peptide_metabolism1.86337452
30MP0002148_abnormal_hypersensitivity_rea1.79215308
31MP0002398_abnormal_bone_marrow1.76449050
32MP0009764_decreased_sensitivity_to1.76052588
33MP0005174_abnormal_tail_pigmentation1.72309203
34MP0001529_abnormal_vocalization1.72052084
35MP0006072_abnormal_retinal_apoptosis1.70605516
36MP0004782_abnormal_surfactant_physiolog1.67334484
37MP0000427_abnormal_hair_cycle1.65660799
38MP0000015_abnormal_ear_pigmentation1.63797342
39MP0003186_abnormal_redox_activity1.62061874
40MP0010094_abnormal_chromosome_stability1.61159657
41MP0000689_abnormal_spleen_morphology1.60759553
42MP0000716_abnormal_immune_system1.59600416
43MP0010155_abnormal_intestine_physiology1.59348180
44MP0005085_abnormal_gallbladder_physiolo1.57904479
45MP0009333_abnormal_splenocyte_physiolog1.57810366
46MP0008875_abnormal_xenobiotic_pharmacok1.56628669
47MP0006082_CNS_inflammation1.56390325
48MP0003172_abnormal_lysosome_physiology1.54548137
49MP0003252_abnormal_bile_duct1.54099249
50MP0001845_abnormal_inflammatory_respons1.53116206
51MP0005253_abnormal_eye_physiology1.52049411
52MP0001853_heart_inflammation1.47989267
53MP0001764_abnormal_homeostasis1.47500978
54MP0004142_abnormal_muscle_tone1.47360083
55MP0003786_premature_aging1.46511549
56MP0002722_abnormal_immune_system1.45518092
57MP0003806_abnormal_nucleotide_metabolis1.44794882
58MP0002006_tumorigenesis1.43016768
59MP0005075_abnormal_melanosome_morpholog1.42847148
60MP0001485_abnormal_pinna_reflex1.40568747
61MP0002166_altered_tumor_susceptibility1.40174108
62MP0002095_abnormal_skin_pigmentation1.40038886
63MP0001873_stomach_inflammation1.39925939
64MP0008789_abnormal_olfactory_epithelium1.38136463
65MP0002429_abnormal_blood_cell1.38064799
66MP0003724_increased_susceptibility_to1.37624287
67MP0008469_abnormal_protein_level1.36600938
68MP0002876_abnormal_thyroid_physiology1.35485470
69MP0002933_joint_inflammation1.34861505
70MP0000490_abnormal_crypts_of1.32927862
71MP0002132_abnormal_respiratory_system1.28007967
72MP0002163_abnormal_gland_morphology1.27313445
73MP0005171_absent_coat_pigmentation1.27015521
74MP0008995_early_reproductive_senescence1.25574020
75MP0005551_abnormal_eye_electrophysiolog1.24901810
76MP0002405_respiratory_system_inflammati1.24629782
77MP0000372_irregular_coat_pigmentation1.23206086
78MP0003191_abnormal_cellular_cholesterol1.22271522
79MP0002837_dystrophic_cardiac_calcinosis1.19976331
80MP0005084_abnormal_gallbladder_morpholo1.18695564
81MP0005397_hematopoietic_system_phenotyp1.17370214
82MP0001545_abnormal_hematopoietic_system1.17370214
83MP0003136_yellow_coat_color1.17075022
84MP0005310_abnormal_salivary_gland1.16087756
85MP0003693_abnormal_embryo_hatching1.14695796
86MP0004883_abnormal_blood_vessel1.14184392
87MP0000465_gastrointestinal_hemorrhage1.14117918
88MP0006035_abnormal_mitochondrial_morpho1.12733060
89MP0003868_abnormal_feces_composition1.11579571
90MP0004808_abnormal_hematopoietic_stem1.11298518
91MP0008057_abnormal_DNA_replication1.06428699
92MP0005389_reproductive_system_phenotype1.05607444
93MP0002102_abnormal_ear_morphology1.01545296
94MP0001984_abnormal_olfaction1.01189125
95MP0005408_hypopigmentation1.00916376
96MP0004043_abnormal_pH_regulation1.00865920
97MP0002638_abnormal_pupillary_reflex0.99916326
98MP0003221_abnormal_cardiomyocyte_apopto0.98689121
99MP0008872_abnormal_physiological_respon0.95356991
100MP0003121_genomic_imprinting0.94607563
101MP0005499_abnormal_olfactory_system0.93484438
102MP0005394_taste/olfaction_phenotype0.93484438
103MP0001919_abnormal_reproductive_system0.93142958
104MP0000609_abnormal_liver_physiology0.92977551
105MP0006292_abnormal_olfactory_placode0.92128551
106MP0006276_abnormal_autonomic_nervous0.91837121
107MP0000681_abnormal_thyroid_gland0.91411672
108MP0001986_abnormal_taste_sensitivity0.91334130
109MP0002277_abnormal_respiratory_mucosa0.90977755
110MP0003011_delayed_dark_adaptation0.90003580
111MP0002928_abnormal_bile_duct0.89307222
112MP0005379_endocrine/exocrine_gland_phen0.89134527
113MP0000703_abnormal_thymus_morphology0.88209924
114MP0009763_increased_sensitivity_to0.87933286
115MP0005266_abnormal_metabolism0.86572163
116MP0009046_muscle_twitch0.85288374
117MP0008058_abnormal_DNA_repair0.84790799
118MP0001533_abnormal_skeleton_physiology0.84553117
119MP0002160_abnormal_reproductive_system0.81428186
120MP0010329_abnormal_lipoprotein_level0.81266636
121MP0003950_abnormal_plasma_membrane0.80713584
122MP0001188_hyperpigmentation0.80073498
123MP0000598_abnormal_liver_morphology0.79420447
124MP0003077_abnormal_cell_cycle0.79310981
125MP0006036_abnormal_mitochondrial_physio0.79138953
126MP0002693_abnormal_pancreas_physiology0.78897798
127MP0005058_abnormal_lysosome_morphology0.77522510
128MP0000371_diluted_coat_color0.76862162
129MP0005319_abnormal_enzyme/_coenzyme0.76718353
130MP0001119_abnormal_female_reproductive0.76415308
131MP0001881_abnormal_mammary_gland0.76306133
132MP0001501_abnormal_sleep_pattern0.75923724
133MP0005584_abnormal_enzyme/coenzyme_acti0.75508546
134MP0005645_abnormal_hypothalamus_physiol0.74668689
135MP0004742_abnormal_vestibular_system0.74211452
136MP0004947_skin_inflammation0.73935001
137MP0001663_abnormal_digestive_system0.73354852
138MP0004133_heterotaxia0.72657191
139MP0003866_abnormal_defecation0.72292960
140MP0000343_altered_response_to0.71804115
141MP0003828_pulmonary_edema0.70980357
142MP0001929_abnormal_gametogenesis0.70843802
143MP0002909_abnormal_adrenal_gland0.69289569
144MP0002138_abnormal_hepatobiliary_system0.68640540

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)5.17490540
2Recurrent bacterial skin infections (HP:0005406)4.73408126
3Recurrent abscess formation (HP:0002722)4.70561466
4Abnormality of the prostate (HP:0008775)4.01908670
5Panhypogammaglobulinemia (HP:0003139)3.59432280
6IgM deficiency (HP:0002850)3.59117960
7Recurrent viral infections (HP:0004429)3.51796394
8Molar tooth sign on MRI (HP:0002419)3.32620832
9Abnormality of midbrain morphology (HP:0002418)3.32620832
10Abnormality of the heme biosynthetic pathway (HP:0010472)3.05039365
11Stomatitis (HP:0010280)3.04606842
12Abnormality of the renal cortex (HP:0011035)3.03013723
13Recurrent skin infections (HP:0001581)3.02497773
14Reduced antithrombin III activity (HP:0001976)2.98009987
15Nephronophthisis (HP:0000090)2.91696929
16Recurrent gram-negative bacterial infections (HP:0005420)2.90118355
17Eczematoid dermatitis (HP:0000976)2.89000901
18Elevated erythrocyte sedimentation rate (HP:0003565)2.88031140
19White forelock (HP:0002211)2.84804732
20Patchy hypopigmentation of hair (HP:0011365)2.81408203
21Agammaglobulinemia (HP:0004432)2.79952664
22Abnormality of T cell number (HP:0011839)2.77822714
23Myositis (HP:0100614)2.77356813
24T lymphocytopenia (HP:0005403)2.73929604
25Absent rod-and cone-mediated responses on ERG (HP:0007688)2.70156354
26Abnormality of alanine metabolism (HP:0010916)2.65559086
27Hyperalaninemia (HP:0003348)2.65559086
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.65559086
29Hypoplasia of the thymus (HP:0000778)2.64934852
30Congenital stationary night blindness (HP:0007642)2.63003580
31Meningitis (HP:0001287)2.61699573
32Type II lissencephaly (HP:0007260)2.59916220
33Progressive inability to walk (HP:0002505)2.57896856
34Encephalitis (HP:0002383)2.56768206
35Renal cortical cysts (HP:0000803)2.53575709
36Recurrent fungal infections (HP:0002841)2.52819054
37Increased hepatocellular lipid droplets (HP:0006565)2.52648175
38Chronic diarrhea (HP:0002028)2.52438857
39Cortical dysplasia (HP:0002539)2.48845388
40Methylmalonic acidemia (HP:0002912)2.47905882
41Lipid accumulation in hepatocytes (HP:0006561)2.46338452
42Abnormality of the renal medulla (HP:0100957)2.45977959
43Abnormal rod and cone electroretinograms (HP:0008323)2.43280681
44Chronic hepatic failure (HP:0100626)2.42471329
45Petechiae (HP:0000967)2.41963972
46Abnormality of B cell number (HP:0010975)2.40993413
47B lymphocytopenia (HP:0010976)2.40993413
48Mitochondrial inheritance (HP:0001427)2.40988981
49Increased CSF lactate (HP:0002490)2.39478211
50Abnormality of lateral ventricle (HP:0030047)2.39159986
51Thyroiditis (HP:0100646)2.39146993
52Abolished electroretinogram (ERG) (HP:0000550)2.38384560
53Type 2 muscle fiber atrophy (HP:0003554)2.38290810
54Abnormality of the right ventricle (HP:0001707)2.37188381
55Birth length less than 3rd percentile (HP:0003561)2.35692703
56Osteomyelitis (HP:0002754)2.35519714
57Medial flaring of the eyebrow (HP:0010747)2.33422204
583-Methylglutaconic aciduria (HP:0003535)2.32008802
59Recurrent pneumonia (HP:0006532)2.28863573
60Recurrent sinusitis (HP:0011108)2.27100091
61Mediastinal lymphadenopathy (HP:0100721)2.26825214
62Stomach cancer (HP:0012126)2.26507930
63Abnormality of male internal genitalia (HP:0000022)2.26421662
64Hypochromic microcytic anemia (HP:0004840)2.24171512
65Volvulus (HP:0002580)2.23724882
66Clubbing of toes (HP:0100760)2.23102874
67Lymphopenia (HP:0001888)2.20743948
68Vasculitis (HP:0002633)2.19613898
69Acute necrotizing encephalopathy (HP:0006965)2.17368453
70Abnormality of cells of the lymphoid lineage (HP:0012140)2.17318433
71Albinism (HP:0001022)2.17215735
72Epistaxis (HP:0000421)2.16744363
73Attenuation of retinal blood vessels (HP:0007843)2.16402497
74Abnormal foot bone ossification (HP:0010675)2.15237412
75Cellulitis (HP:0100658)2.14381920
76Progressive macrocephaly (HP:0004481)2.13447727
77Aplastic anemia (HP:0001915)2.13042475
78Hyperventilation (HP:0002883)2.12069008
79Type I transferrin isoform profile (HP:0003642)2.11848342
80Poor head control (HP:0002421)2.10903685
81Orchitis (HP:0100796)2.10552320
82Gingival bleeding (HP:0000225)2.08503732
83Periodontitis (HP:0000704)2.08239995
84Fair hair (HP:0002286)2.07776793
85Vertebral compression fractures (HP:0002953)2.07580636
86Generalized aminoaciduria (HP:0002909)2.07474352
87Pancreatic fibrosis (HP:0100732)2.07127142
88Retrobulbar optic neuritis (HP:0100654)2.07034523
89Optic neuritis (HP:0100653)2.07034523
90Hepatocellular necrosis (HP:0001404)2.06193395
91Hyperbilirubinemia (HP:0002904)2.05722869
92Conjugated hyperbilirubinemia (HP:0002908)2.05383502
93Inability to walk (HP:0002540)2.04550460
94Eosinophilia (HP:0001880)2.02814829
95Intrahepatic cholestasis (HP:0001406)2.02282299
96Thrombocytosis (HP:0001894)2.00688245
97Renal Fanconi syndrome (HP:0001994)2.00406100
98Autoimmune thrombocytopenia (HP:0001973)1.99628985
99Hepatic necrosis (HP:0002605)1.98932353
100Methylmalonic aciduria (HP:0012120)1.96859820
101Prolonged bleeding time (HP:0003010)1.96788690
102Lymphoma (HP:0002665)1.96372291
103Abnormality of chromosome stability (HP:0003220)1.95852837
104Joint hemorrhage (HP:0005261)1.95421124
105Granulocytopenia (HP:0001913)1.94690967
106Gaze-evoked nystagmus (HP:0000640)1.93668961
107IgG deficiency (HP:0004315)1.93245968
108Aplasia/Hypoplasia of the tongue (HP:0010295)1.93030224
109Chromsome breakage (HP:0040012)1.92441989
110Metaphyseal dysplasia (HP:0100255)1.91644224
111Abnormality of T cell physiology (HP:0011840)1.91163891
112Pulmonary infiltrates (HP:0002113)1.89618586
113Sclerocornea (HP:0000647)1.89311648
114Bile duct proliferation (HP:0001408)1.88808548
115Abnormal biliary tract physiology (HP:0012439)1.88808548
116Acanthocytosis (HP:0001927)1.88649388
117Anencephaly (HP:0002323)1.88577709
118Neoplasm of the adrenal cortex (HP:0100641)1.87683217
119Keratoconjunctivitis sicca (HP:0001097)1.87028470
120Dyschromatopsia (HP:0007641)1.86856938
121Lissencephaly (HP:0001339)1.86826715
122Congenital primary aphakia (HP:0007707)1.86384332
123Chromosomal breakage induced by crosslinking agents (HP:0003221)1.85613371
124Increased neuronal autofluorescent lipopigment (HP:0002074)1.85105248
125True hermaphroditism (HP:0010459)1.84798593
126Skin rash (HP:0000988)1.84767153
127Abnormality of macrophages (HP:0004311)1.84737848
128Abnormality of DNA repair (HP:0003254)1.84338029
129Recurrent cutaneous fungal infections (HP:0011370)1.83453428
130Chronic mucocutaneous candidiasis (HP:0002728)1.83453428
131Cerebellar dysplasia (HP:0007033)1.83372136
132Postaxial foot polydactyly (HP:0001830)1.83268035
133Sepsis (HP:0100806)1.82420527
134Increased serum lactate (HP:0002151)1.81140912
135Microcytic anemia (HP:0001935)1.80935799
136Neutropenia (HP:0001875)1.80919387
137Optic nerve coloboma (HP:0000588)1.80650557
138Abnormal delayed hypersensitivity skin test (HP:0002963)1.80116044
139Constricted visual fields (HP:0001133)1.79860515
140Hypothermia (HP:0002045)1.79610546
141Hypoproteinemia (HP:0003075)1.79582838
142Prostate neoplasm (HP:0100787)1.79470758
143Pulmonary fibrosis (HP:0002206)1.79106888
144Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78584266
145Abnormal protein N-linked glycosylation (HP:0012347)1.78584266
146Abnormal protein glycosylation (HP:0012346)1.78584266
147Abnormal glycosylation (HP:0012345)1.78584266
148Nephrogenic diabetes insipidus (HP:0009806)1.77909514
149Cystic liver disease (HP:0006706)1.77849389
150Pancreatic cysts (HP:0001737)1.77751260
151Gait imbalance (HP:0002141)1.77499378
152Acute myeloid leukemia (HP:0004808)1.77394896
153Acute encephalopathy (HP:0006846)1.76982664
154Muscle fiber atrophy (HP:0100295)1.76476643
155Congenital hepatic fibrosis (HP:0002612)1.76301563
156Absent speech (HP:0001344)1.75800900
157Furrowed tongue (HP:0000221)1.75633081
158Severe combined immunodeficiency (HP:0004430)1.74452088
159Widely spaced teeth (HP:0000687)1.73834934
160Leukocytosis (HP:0001974)1.73470100
161Impaired platelet aggregation (HP:0003540)1.73364684
162Abnormal platelet function (HP:0011869)1.73364684
163Abnormality of T cells (HP:0002843)1.71433358
164Aplasia/Hypoplasia of the uvula (HP:0010293)1.70206884
165Agnosia (HP:0010524)1.69951018
166Vacuolated lymphocytes (HP:0001922)1.69840356
167Abnormal mitochondria in muscle tissue (HP:0008316)1.69365246
168Abnormality of the pons (HP:0007361)1.69097804
169Poikilocytosis (HP:0004447)1.69042815
170Tubulointerstitial nephritis (HP:0001970)1.68396315
171Congenital sensorineural hearing impairment (HP:0008527)1.64373423
172Colon cancer (HP:0003003)1.63640440
173Abnormal drinking behavior (HP:0030082)1.63117662
174Polydipsia (HP:0001959)1.63117662

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.37134306
2TEC3.98518176
3MAP3K142.91253682
4MAP4K12.86141165
5BTK2.67771836
6TXK2.66089218
7BLK2.51072568
8KIT2.49016696
9FLT32.40283867
10TAOK32.16761264
11TYK22.15725961
12CAMKK22.13087650
13ITK2.12931586
14BRSK22.12485960
15MUSK1.99968306
16MAP4K21.99781976
17IRAK41.90081492
18SIK31.88584011
19MAP3K121.83821223
20SYK1.79067547
21CSF1R1.73776121
22NEK91.66966675
23BCKDK1.62439569
24ACVR1B1.62297615
25JAK31.61196991
26ERBB31.60573543
27TRIM281.58960945
28TLK11.57733709
29TNIK1.55324914
30VRK21.55135008
31MAP3K41.48851952
32ZAP701.48589333
33OXSR11.45912499
34NUAK11.41431055
35PIM21.33562288
36STK101.31952039
37PBK1.31790129
38STK241.31474274
39WNK31.30826396
40TBK11.29655679
41NEK11.28619300
42PLK31.25392673
43PLK21.24641062
44IRAK31.23463959
45MST41.23425574
46LYN1.23099874
47BRSK11.21898406
48CDK81.21125255
49EIF2AK11.21046043
50GRK71.17830237
51STK38L1.15560925
52IKBKB1.11531598
53CCNB11.11199516
54ADRBK21.10731477
55STK391.10247940
56MAP3K61.09363220
57MKNK21.06676979
58PAK31.05122300
59MAPK131.03251548
60NLK1.03166338
61PIM11.03005683
62DYRK31.01352963
63BMPR21.00627778
64JAK11.00355584
65TAOK21.00270785
66BCR1.00010885
67IKBKE0.99992439
68LCK0.97876955
69CSNK1G20.96173703
70GRK60.95012173
71MAP3K50.93842177
72MARK30.93141602
73CSNK1G30.92601290
74CSNK1G10.90885122
75VRK10.90042091
76FES0.89682571
77STK40.86122542
78PTK2B0.84451692
79CSNK1A1L0.83973015
80TGFBR20.81909931
81TAF10.80808318
82CASK0.80331606
83ERBB40.80024445
84EIF2AK20.79852162
85CHUK0.78768666
86YES10.78475504
87PIK3CG0.76845602
88INSRR0.74350672
89ATR0.74251250
90NEK60.71746498
91SGK20.71338226
92HCK0.71102511
93STK160.70922376
94WEE10.69397405
95TRPM70.69345169
96NME20.68699293
97ERN10.67264132
98RPS6KA50.66331954
99TGFBR10.65719039
100RPS6KA40.65554100
101CSK0.65019265
102PIK3CA0.64479686
103IRAK10.63479778
104ADRBK10.63292877
105CDC70.61681219
106TAOK10.61512107
107MKNK10.61416860
108WNK40.60853627
109FGR0.60777116
110MAP2K30.59561174
111CDK60.56775295
112PRKCQ0.56384976
113GRK50.54627373
114ABL10.54039604
115EIF2AK30.53048055
116JAK20.51331134
117DYRK1A0.51162043
118CDK40.51154603
119BUB10.50539217
120MAP2K60.50376378
121IGF1R0.49564000
122PLK40.49384165
123MAPK40.49305233
124ZAK0.49272747
125RPS6KB10.49021235
126PINK10.48425466
127BMPR1B0.47896735
128ERBB20.45509668
129PRPF4B0.45476702
130BRD40.42350828
131SRPK10.42328943
132CDK70.42202779
133MINK10.41977392
134MAPK110.41548718
135PRKCD0.41058633
136DYRK20.41038485
137CDK90.40027911
138MAPK30.39951003
139EGFR0.38603788
140BRAF0.38052921
141GRK10.37205928
142KSR10.36906464
143PRKCE0.36752137
144MAP2K70.36257240
145SGK30.36230234
146AURKB0.33143019
147CLK10.32783394

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.70782657
2Primary immunodeficiency_Homo sapiens_hsa053402.58133326
3Oxidative phosphorylation_Homo sapiens_hsa001902.40374746
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.34285056
5Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.33101060
6Caffeine metabolism_Homo sapiens_hsa002322.12981616
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.08935038
8RNA polymerase_Homo sapiens_hsa030202.07373100
9Parkinsons disease_Homo sapiens_hsa050122.05842923
10DNA replication_Homo sapiens_hsa030301.96821332
11Base excision repair_Homo sapiens_hsa034101.94148299
12Phototransduction_Homo sapiens_hsa047441.91448834
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.84716339
14Measles_Homo sapiens_hsa051621.83310343
15Sulfur metabolism_Homo sapiens_hsa009201.81515343
16Leishmaniasis_Homo sapiens_hsa051401.81313549
17Drug metabolism - other enzymes_Homo sapiens_hsa009831.80384775
18Other glycan degradation_Homo sapiens_hsa005111.77395642
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.74736302
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.74207392
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.66798327
22Peroxisome_Homo sapiens_hsa041461.65884554
23Staphylococcus aureus infection_Homo sapiens_hsa051501.64605674
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.56859615
25Herpes simplex infection_Homo sapiens_hsa051681.55058132
26Selenocompound metabolism_Homo sapiens_hsa004501.54977401
27Allograft rejection_Homo sapiens_hsa053301.54007987
28Butanoate metabolism_Homo sapiens_hsa006501.51874765
29Graft-versus-host disease_Homo sapiens_hsa053321.49924595
30Non-homologous end-joining_Homo sapiens_hsa034501.47997974
31Homologous recombination_Homo sapiens_hsa034401.45408121
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.41878956
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.41853015
34Fanconi anemia pathway_Homo sapiens_hsa034601.41666851
35B cell receptor signaling pathway_Homo sapiens_hsa046621.40343762
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.37341985
37Ether lipid metabolism_Homo sapiens_hsa005651.36130979
38One carbon pool by folate_Homo sapiens_hsa006701.30418209
39Mismatch repair_Homo sapiens_hsa034301.30122676
40Asthma_Homo sapiens_hsa053101.30025317
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.27813691
42Nitrogen metabolism_Homo sapiens_hsa009101.27508735
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.27050251
44Linoleic acid metabolism_Homo sapiens_hsa005911.26051810
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.25897607
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25042325
47Starch and sucrose metabolism_Homo sapiens_hsa005001.24284549
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.23837758
49Hematopoietic cell lineage_Homo sapiens_hsa046401.23555091
50Tryptophan metabolism_Homo sapiens_hsa003801.22174068
51Propanoate metabolism_Homo sapiens_hsa006401.22020086
52Huntingtons disease_Homo sapiens_hsa050161.21129140
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20992479
54Antigen processing and presentation_Homo sapiens_hsa046121.20918943
55Vitamin B6 metabolism_Homo sapiens_hsa007501.20774029
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20708979
57Osteoclast differentiation_Homo sapiens_hsa043801.18750915
58Jak-STAT signaling pathway_Homo sapiens_hsa046301.17538125
59Alzheimers disease_Homo sapiens_hsa050101.16910285
60Pentose phosphate pathway_Homo sapiens_hsa000301.16649350
61Retinol metabolism_Homo sapiens_hsa008301.12632777
62Regulation of autophagy_Homo sapiens_hsa041401.10644106
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10420721
64Glycosaminoglycan degradation_Homo sapiens_hsa005311.10130601
65Collecting duct acid secretion_Homo sapiens_hsa049661.07019481
66Protein export_Homo sapiens_hsa030601.06981502
67Influenza A_Homo sapiens_hsa051641.06602635
68Legionellosis_Homo sapiens_hsa051341.04316153
69Pyrimidine metabolism_Homo sapiens_hsa002401.02947072
70Folate biosynthesis_Homo sapiens_hsa007901.00498254
71Malaria_Homo sapiens_hsa051440.98636106
72Cell cycle_Homo sapiens_hsa041100.97895940
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93156833
74Complement and coagulation cascades_Homo sapiens_hsa046100.92904463
75Basal transcription factors_Homo sapiens_hsa030220.91595883
76Sulfur relay system_Homo sapiens_hsa041220.90621563
77ABC transporters_Homo sapiens_hsa020100.89684671
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89365077
79Tuberculosis_Homo sapiens_hsa051520.89280646
80Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87556296
81Hepatitis B_Homo sapiens_hsa051610.87402560
82p53 signaling pathway_Homo sapiens_hsa041150.83505307
83Dorso-ventral axis formation_Homo sapiens_hsa043200.83128597
84Vitamin digestion and absorption_Homo sapiens_hsa049770.82726676
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82459695
86Nucleotide excision repair_Homo sapiens_hsa034200.81804901
87Circadian rhythm_Homo sapiens_hsa047100.81774428
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.81411859
89Fatty acid degradation_Homo sapiens_hsa000710.81335108
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81063498
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78492155
92N-Glycan biosynthesis_Homo sapiens_hsa005100.77536449
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.77113482
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75903855
95Apoptosis_Homo sapiens_hsa042100.75443415
96beta-Alanine metabolism_Homo sapiens_hsa004100.74888586
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73823494
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72198924
99Olfactory transduction_Homo sapiens_hsa047400.71716915
100Shigellosis_Homo sapiens_hsa051310.70110159
101Type I diabetes mellitus_Homo sapiens_hsa049400.68818482
102Lysosome_Homo sapiens_hsa041420.68433967
103Proteasome_Homo sapiens_hsa030500.68321024
104RNA degradation_Homo sapiens_hsa030180.68235982
105Acute myeloid leukemia_Homo sapiens_hsa052210.65126554
106Steroid biosynthesis_Homo sapiens_hsa001000.63243299
107Toxoplasmosis_Homo sapiens_hsa051450.61970543
108T cell receptor signaling pathway_Homo sapiens_hsa046600.61759491
109Taste transduction_Homo sapiens_hsa047420.59892735
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59607580
111Purine metabolism_Homo sapiens_hsa002300.58104589
112African trypanosomiasis_Homo sapiens_hsa051430.57119310
113Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56842976
114Pertussis_Homo sapiens_hsa051330.56182726
115Histidine metabolism_Homo sapiens_hsa003400.55165841
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54837234
117Hepatitis C_Homo sapiens_hsa051600.54701256
118Chemical carcinogenesis_Homo sapiens_hsa052040.54476379
119Galactose metabolism_Homo sapiens_hsa000520.53536553
120Autoimmune thyroid disease_Homo sapiens_hsa053200.52570595
121Rheumatoid arthritis_Homo sapiens_hsa053230.52367855
122Nicotine addiction_Homo sapiens_hsa050330.52074122
123RNA transport_Homo sapiens_hsa030130.51960561
124Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48929454
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48487882
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47713665
127TNF signaling pathway_Homo sapiens_hsa046680.47101169
128Spliceosome_Homo sapiens_hsa030400.46379861
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45578453
130Phagosome_Homo sapiens_hsa041450.45135540
131Pancreatic cancer_Homo sapiens_hsa052120.44039042
132Epstein-Barr virus infection_Homo sapiens_hsa051690.42619960
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42276137
134Chemokine signaling pathway_Homo sapiens_hsa040620.41542924
135Metabolic pathways_Homo sapiens_hsa011000.40581251
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39577657
137GABAergic synapse_Homo sapiens_hsa047270.33043759

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