NSUN5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of an evolutionarily conserved family of proteins that may function as methyltransferases. This gene is located in a larger region of chromosome 7 that is deleted in Williams-Beuren syndrome, a multisystem developmental disorder. There are two pseudogenes for this gene located in the same region of chromosome 7. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)6.69749942
2ribosomal small subunit assembly (GO:0000028)6.09627826
3viral transcription (GO:0019083)6.08862094
4translational termination (GO:0006415)5.95762873
5DNA deamination (GO:0045006)5.75337403
6ribosomal small subunit biogenesis (GO:0042274)5.75151004
7ribosomal large subunit biogenesis (GO:0042273)5.49095244
8translational elongation (GO:0006414)5.13400695
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.98910219
10cotranslational protein targeting to membrane (GO:0006613)4.92357155
11protein targeting to ER (GO:0045047)4.88448399
12translational initiation (GO:0006413)4.87007468
13proteasome assembly (GO:0043248)4.86654453
14ribonucleoprotein complex biogenesis (GO:0022613)4.77467183
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.73498029
16cellular protein complex disassembly (GO:0043624)4.70309231
17establishment of protein localization to endoplasmic reticulum (GO:0072599)4.65340516
18protein localization to endoplasmic reticulum (GO:0070972)4.59058996
19viral life cycle (GO:0019058)4.56326950
20pseudouridine synthesis (GO:0001522)4.48185466
21pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.46085457
22DNA strand elongation involved in DNA replication (GO:0006271)4.35833562
23transcription elongation from RNA polymerase III promoter (GO:0006385)4.27731638
24termination of RNA polymerase III transcription (GO:0006386)4.27731638
25* rRNA processing (GO:0006364)4.27576094
26DNA replication initiation (GO:0006270)4.23581338
27telomere maintenance via semi-conservative replication (GO:0032201)4.19171067
28nucleobase biosynthetic process (GO:0046112)4.18142019
29ribosome biogenesis (GO:0042254)4.17987095
30protein complex disassembly (GO:0043241)4.15970931
31DNA replication checkpoint (GO:0000076)4.14731062
32DNA strand elongation (GO:0022616)4.14389485
33* rRNA metabolic process (GO:0016072)4.12665586
34spliceosomal snRNP assembly (GO:0000387)4.09421314
35purine nucleobase biosynthetic process (GO:0009113)4.06113857
36DNA unwinding involved in DNA replication (GO:0006268)4.01787701
37cellular component biogenesis (GO:0044085)3.97909856
38macromolecular complex disassembly (GO:0032984)3.96583217
39translation (GO:0006412)3.94808859
40peptidyl-arginine omega-N-methylation (GO:0035247)3.91596611
41formation of translation preinitiation complex (GO:0001731)3.84823829
42pyrimidine nucleotide catabolic process (GO:0006244)3.77039214
43nuclear-transcribed mRNA catabolic process (GO:0000956)3.72134357
44base-excision repair, AP site formation (GO:0006285)3.70215191
45CENP-A containing nucleosome assembly (GO:0034080)3.64929270
46spliceosomal complex assembly (GO:0000245)3.64538175
47exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.63374506
48rRNA modification (GO:0000154)3.61333961
49telomere maintenance via recombination (GO:0000722)3.60687429
50chromatin remodeling at centromere (GO:0031055)3.58944674
51pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.55553151
52mRNA catabolic process (GO:0006402)3.52077717
53mitotic metaphase plate congression (GO:0007080)3.50262898
54negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.49740311
55DNA damage response, detection of DNA damage (GO:0042769)3.45635544
56nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.44651727
57histone arginine methylation (GO:0034969)3.44032508
58telomere maintenance via telomere lengthening (GO:0010833)3.39729876
59mitotic recombination (GO:0006312)3.37484802
60RNA catabolic process (GO:0006401)3.37252874
61transcription elongation from RNA polymerase I promoter (GO:0006362)3.36454301
62tRNA methylation (GO:0030488)3.36215144
63ncRNA 3-end processing (GO:0043628)3.36057616
64transcription-coupled nucleotide-excision repair (GO:0006283)3.34804892
65ribosome assembly (GO:0042255)3.30892774
66anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.30819734
67regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.29568885
68* ncRNA processing (GO:0034470)3.29175524
69termination of RNA polymerase I transcription (GO:0006363)3.28990034
70viral mRNA export from host cell nucleus (GO:0046784)3.28635784
71deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.28487075
72L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.27450666
73positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.26441791
74iron-sulfur cluster assembly (GO:0016226)3.25848052
75metallo-sulfur cluster assembly (GO:0031163)3.25848052
767-methylguanosine mRNA capping (GO:0006370)3.25734640
77guanosine-containing compound biosynthetic process (GO:1901070)3.24422014
78negative regulation of DNA-templated transcription, elongation (GO:0032785)3.23599698
797-methylguanosine RNA capping (GO:0009452)3.22944994
80RNA capping (GO:0036260)3.22944994
81negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.21744729
82peptidyl-arginine methylation (GO:0018216)3.21542286
83peptidyl-arginine N-methylation (GO:0035246)3.21542286
84negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.20046033
85negative regulation of ligase activity (GO:0051352)3.20046033
86establishment of integrated proviral latency (GO:0075713)3.19731539
87nucleotide-excision repair, DNA gap filling (GO:0006297)3.18289867
88transcription from RNA polymerase I promoter (GO:0006360)3.17754521
89pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.17007086
90* ncRNA metabolic process (GO:0034660)3.16184013
91protein targeting to membrane (GO:0006612)3.15902019
92DNA replication-independent nucleosome organization (GO:0034724)3.14941346
93DNA replication-independent nucleosome assembly (GO:0006336)3.14941346
94maturation of 5.8S rRNA (GO:0000460)3.13669781
95chaperone-mediated protein transport (GO:0072321)3.13308936
96pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.11103074
97mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.09940402
98UTP biosynthetic process (GO:0006228)3.08010178
99spliceosomal tri-snRNP complex assembly (GO:0000244)3.07285513
100metaphase plate congression (GO:0051310)3.05892199
101protein targeting to mitochondrion (GO:0006626)3.04776076
102DNA-templated transcription, termination (GO:0006353)3.04710946
103pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.00074769
104establishment of protein localization to mitochondrial membrane (GO:0090151)2.97644927
105kinetochore assembly (GO:0051382)2.96701540
106regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.96037539
107IMP biosynthetic process (GO:0006188)2.95330152
108GTP biosynthetic process (GO:0006183)2.94188617
109regulation of mitochondrial translation (GO:0070129)2.92193652
110kinetochore organization (GO:0051383)2.91051586
111histone mRNA metabolic process (GO:0008334)2.90143863
112CTP biosynthetic process (GO:0006241)2.89851585
113CTP metabolic process (GO:0046036)2.89851585
114DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.88719407
115energy coupled proton transport, down electrochemical gradient (GO:0015985)2.88357802
116ATP synthesis coupled proton transport (GO:0015986)2.88357802
117establishment of protein localization to mitochondrion (GO:0072655)2.88270600
118transcription from mitochondrial promoter (GO:0006390)2.88204837
119histone exchange (GO:0043486)2.87983084
120protein localization to kinetochore (GO:0034501)2.87755052
121regulation of double-strand break repair via homologous recombination (GO:0010569)2.87557792
122deoxyribonucleotide catabolic process (GO:0009264)2.86451110
123negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.85520863
124positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.85153888
125regulation of cellular amino acid metabolic process (GO:0006521)2.84604554
126signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.83507461
127signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.83507461
128signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.83507461
129deoxyribose phosphate catabolic process (GO:0046386)2.80206920
130pentose metabolic process (GO:0019321)2.79287471
131rRNA transcription (GO:0009303)2.77613844
132pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.75001811
133base-excision repair (GO:0006284)2.74454821
134UTP metabolic process (GO:0046051)2.73415777
135regulation of translational fidelity (GO:0006450)2.73285526
136negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.72828840
137establishment of viral latency (GO:0019043)2.71839979
138regulation of translational termination (GO:0006449)2.71577108
139mitochondrial respiratory chain complex I assembly (GO:0032981)2.70435867
140NADH dehydrogenase complex assembly (GO:0010257)2.70435867
141mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.70435867
142protein localization to mitochondrion (GO:0070585)2.70299552
143mitochondrial respiratory chain complex assembly (GO:0033108)2.67253566
144regulation of chromatin binding (GO:0035561)2.66515372

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.93690816
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.85446125
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.88347060
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.75992517
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.67268183
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.53677091
7* ETS1_20019798_ChIP-Seq_JURKAT_Human3.52754986
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.50335909
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.38381401
10MYC_18358816_ChIP-ChIP_MESCs_Mouse3.31509926
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.29339046
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.17568645
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.11042758
14* E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.10016500
15MYC_19030024_ChIP-ChIP_MESCs_Mouse3.09035107
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.04387437
17CREB1_15753290_ChIP-ChIP_HEK293T_Human3.02890009
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.93447931
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.87127275
20XRN2_22483619_ChIP-Seq_HELA_Human2.66983092
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.64182415
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.57324159
23VDR_23849224_ChIP-Seq_CD4+_Human2.54427680
24* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.53737337
25FOXP3_21729870_ChIP-Seq_TREG_Human2.28858807
26DCP1A_22483619_ChIP-Seq_HELA_Human2.24985140
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.24197262
28* TTF2_22483619_ChIP-Seq_HELA_Human2.21173582
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.20342904
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.17094452
31* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15770320
32* GABP_19822575_ChIP-Seq_HepG2_Human2.13109612
33YY1_21170310_ChIP-Seq_MESCs_Mouse2.04521256
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90806547
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89174267
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.87797472
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.81332743
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81205697
39CIITA_25753668_ChIP-Seq_RAJI_Human1.80288070
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78244191
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.77461935
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.76844508
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.75867919
44* SRF_21415370_ChIP-Seq_HL-1_Mouse1.73390118
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72109920
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71834852
47* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69333489
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66267409
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.56622179
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56462240
51ELK1_19687146_ChIP-ChIP_HELA_Human1.56027517
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55639553
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50919036
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50902589
55* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45522711
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43050621
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.41728691
58AR_21909140_ChIP-Seq_LNCAP_Human1.41140434
59KDM5A_27292631_Chip-Seq_BREAST_Human1.40829609
60ZNF263_19887448_ChIP-Seq_K562_Human1.38178604
61KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.34636482
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34254325
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.33987762
64MYC_18940864_ChIP-ChIP_HL60_Human1.32485092
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.32161930
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31384592
67CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29320859
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23841921
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22601277
70LXR_22292898_ChIP-Seq_THP-1_Human1.21475609
71ELK1_22589737_ChIP-Seq_MCF10A_Human1.20147530
72P68_20966046_ChIP-Seq_HELA_Human1.19855792
73MAF_26560356_Chip-Seq_TH2_Human1.18896777
74MYC_22102868_ChIP-Seq_BL_Human1.17440299
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17292248
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.16714186
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15838525
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15456950
79UTX_26944678_Chip-Seq_JUKART_Human1.13512284
80MAF_26560356_Chip-Seq_TH1_Human1.13303360
81NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12261604
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10066796
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08137557
84ELF1_20517297_ChIP-Seq_JURKAT_Human1.08092804
85* BCL6_27268052_Chip-Seq_Bcells_Human1.07287011
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07177193
87CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06848866
88RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04933494
89PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04828025
90KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04581133
91* CTCF_26484167_Chip-Seq_Bcells_Mouse1.04341717
92KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03686690
93ELK3_25401928_ChIP-Seq_HUVEC_Human1.03670821
94KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01619917
95* BCOR_27268052_Chip-Seq_Bcells_Human1.01091516
96KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00813010
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00043371
98PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99435459
99CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99299519
100* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97826490
101SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96470701
102STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95926037
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95652457
104SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94896018
105RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93472614
106SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93359374
107VDR_21846776_ChIP-Seq_THP-1_Human0.92540243
108SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.87372228
109CTCF_18555785_ChIP-Seq_MESCs_Mouse0.86877017
110SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86344817
111IRF1_19129219_ChIP-ChIP_H3396_Human0.84512766
112* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83351220
113CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82125953
114FOXP1_21924763_ChIP-Seq_HESCs_Human0.81784560
115* YY1_22570637_ChIP-Seq_MALME-3M_Human0.78950632
116SPI1_23547873_ChIP-Seq_NB4_Human0.77470773
117CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.75049334
118TFEB_21752829_ChIP-Seq_HELA_Human0.73527913
119NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.72076697
120SOX2_18692474_ChIP-Seq_MEFs_Mouse0.71330164
121ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.69957987
122EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.69009896
123CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.68908925
124OCT4_18692474_ChIP-Seq_MEFs_Mouse0.68600064

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.69589425
2MP0003111_abnormal_nucleus_morphology4.29421557
3MP0010094_abnormal_chromosome_stability4.13252676
4MP0004957_abnormal_blastocyst_morpholog4.10514006
5MP0009379_abnormal_foot_pigmentation3.60080273
6MP0003077_abnormal_cell_cycle3.59518809
7MP0008057_abnormal_DNA_replication3.51758633
8MP0008058_abnormal_DNA_repair3.45274541
9MP0008932_abnormal_embryonic_tissue3.03188583
10MP0002396_abnormal_hematopoietic_system2.46082012
11MP0003786_premature_aging2.39275457
12MP0003123_paternal_imprinting2.30379432
13MP0006292_abnormal_olfactory_placode2.24197336
14MP0008007_abnormal_cellular_replicative2.19439038
15MP0003315_abnormal_perineum_morphology1.99384873
16MP0003718_maternal_effect1.98477541
17MP0008877_abnormal_DNA_methylation1.94562779
18MP0009333_abnormal_splenocyte_physiolog1.86592485
19MP0009278_abnormal_bone_marrow1.80522714
20MP0001730_embryonic_growth_arrest1.76937567
21MP0002132_abnormal_respiratory_system1.69542652
22MP0005671_abnormal_response_to1.68884512
23MP0000490_abnormal_crypts_of1.64906125
24MP0003136_yellow_coat_color1.64462201
25MP0000350_abnormal_cell_proliferation1.60469379
26MP0003763_abnormal_thymus_physiology1.54161666
27MP0003436_decreased_susceptibility_to1.52631479
28MP0002653_abnormal_ependyma_morphology1.52513330
29MP0001529_abnormal_vocalization1.46912712
30MP0005501_abnormal_skin_physiology1.46672126
31MP0002102_abnormal_ear_morphology1.45588093
32MP0001835_abnormal_antigen_presentation1.44688343
33MP0002210_abnormal_sex_determination1.44206133
34MP0002420_abnormal_adaptive_immunity1.43900912
35MP0001819_abnormal_immune_cell1.43648443
36MP0000685_abnormal_immune_system1.43603203
37MP0001800_abnormal_humoral_immune1.43521544
38MP0008995_early_reproductive_senescence1.43119744
39MP0003011_delayed_dark_adaptation1.42667747
40MP0005075_abnormal_melanosome_morpholog1.42562101
41MP0004185_abnormal_adipocyte_glucose1.38362100
42MP0000313_abnormal_cell_death1.37480842
43MP0002723_abnormal_immune_serum1.33052473
44MP0001853_heart_inflammation1.30914700
45MP0001873_stomach_inflammation1.29772918
46MP0010030_abnormal_orbit_morphology1.27790030
47MP0001188_hyperpigmentation1.27562789
48MP0002080_prenatal_lethality1.26459588
49MP0002452_abnormal_antigen_presenting1.26182586
50MP0005025_abnormal_response_to1.25280011
51MP0002148_abnormal_hypersensitivity_rea1.25179921
52MP0003938_abnormal_ear_development1.24302385
53MP0001672_abnormal_embryogenesis/_devel1.23117480
54MP0005380_embryogenesis_phenotype1.23117480
55MP0001697_abnormal_embryo_size1.22535307
56MP0001145_abnormal_male_reproductive1.21454020
57MP0004233_abnormal_muscle_weight1.20169932
58MP0005058_abnormal_lysosome_morphology1.18575453
59MP0005409_darkened_coat_color1.17201156
60MP0002019_abnormal_tumor_incidence1.16926353
61MP0005000_abnormal_immune_tolerance1.16841257
62MP0006036_abnormal_mitochondrial_physio1.16548023
63MP0002085_abnormal_embryonic_tissue1.14771606
64MP0000703_abnormal_thymus_morphology1.14042197
65MP0005174_abnormal_tail_pigmentation1.14033637
66MP0000049_abnormal_middle_ear1.13377572
67MP0006035_abnormal_mitochondrial_morpho1.13093345
68MP0009672_abnormal_birth_weight1.12996593
69MP0008789_abnormal_olfactory_epithelium1.12823062
70MP0002163_abnormal_gland_morphology1.11759349
71MP0001293_anophthalmia1.05821959
72MP0001929_abnormal_gametogenesis1.05645356
73MP0002938_white_spotting1.05477392
74MP0009697_abnormal_copulation1.05408450
75MP0002796_impaired_skin_barrier1.05073631
76MP0001790_abnormal_immune_system1.04965852
77MP0005387_immune_system_phenotype1.04965852
78MP0000653_abnormal_sex_gland1.03243922
79MP0002822_catalepsy1.01993700
80MP0002160_abnormal_reproductive_system1.01965057
81MP0004147_increased_porphyrin_level1.01597446
82MP0003121_genomic_imprinting1.01015171
83MP0002249_abnormal_larynx_morphology1.00127847
84MP0004808_abnormal_hematopoietic_stem0.98972355
85MP0004381_abnormal_hair_follicle0.98206164
86MP0009785_altered_susceptibility_to0.97884088
87MP0001986_abnormal_taste_sensitivity0.97773917
88MP0002722_abnormal_immune_system0.96630049
89MP0002398_abnormal_bone_marrow0.96612372
90MP0003984_embryonic_growth_retardation0.95721649
91MP0005464_abnormal_platelet_physiology0.93543094
92MP0000566_synostosis0.93304207
93MP0002088_abnormal_embryonic_growth/wei0.92523329
94MP0003221_abnormal_cardiomyocyte_apopto0.92475308
95MP0002751_abnormal_autonomic_nervous0.91772035
96MP0000372_irregular_coat_pigmentation0.90383279
97MP0000689_abnormal_spleen_morphology0.90369732
98MP0002419_abnormal_innate_immunity0.90071267
99MP0002095_abnormal_skin_pigmentation0.89687688
100MP0003806_abnormal_nucleotide_metabolis0.86712890
101MP0005451_abnormal_body_composition0.86247039
102MP0001764_abnormal_homeostasis0.84962346
103MP0003567_abnormal_fetal_cardiomyocyte0.82956984
104MP0000358_abnormal_cell_content/0.81741056
105MP0008260_abnormal_autophagy0.81406558
106MP0000858_altered_metastatic_potential0.80791348
107MP0001905_abnormal_dopamine_level0.80403237
108MP0000750_abnormal_muscle_regeneration0.80024337
109MP0004133_heterotaxia0.79549403
110MP0002429_abnormal_blood_cell0.79362220
111MP0003937_abnormal_limbs/digits/tail_de0.79179891
112MP0003186_abnormal_redox_activity0.78776455
113MP0001727_abnormal_embryo_implantation0.77652654
114MP0000678_abnormal_parathyroid_gland0.77406486
115MP0001119_abnormal_female_reproductive0.76633131
116MP0001845_abnormal_inflammatory_respons0.75723828
117MP0001545_abnormal_hematopoietic_system0.74731312
118MP0005397_hematopoietic_system_phenotyp0.74731312
119MP0002638_abnormal_pupillary_reflex0.74676111
120MP0003698_abnormal_male_reproductive0.74426593
121MP0010307_abnormal_tumor_latency0.74401562
122MP0002405_respiratory_system_inflammati0.73708201
123MP0001881_abnormal_mammary_gland0.72723777
124MP0000465_gastrointestinal_hemorrhage0.71831598
125MP0008469_abnormal_protein_level0.71053923
126MP0002084_abnormal_developmental_patter0.71023849
127MP0002277_abnormal_respiratory_mucosa0.70903327
128MP0000613_abnormal_salivary_gland0.70754467
129MP0003656_abnormal_erythrocyte_physiolo0.70444203
130MP0000537_abnormal_urethra_morphology0.69524420
131MP0001485_abnormal_pinna_reflex0.69288322
132MP0005499_abnormal_olfactory_system0.68621707
133MP0005394_taste/olfaction_phenotype0.68621707
134MP0002086_abnormal_extraembryonic_tissu0.68235514
135MP0004858_abnormal_nervous_system0.67772458
136MP0000716_abnormal_immune_system0.65877479
137MP0003119_abnormal_digestive_system0.65245181
138MP0001286_abnormal_eye_development0.64408374

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.96266892
2Abnormal number of erythroid precursors (HP:0012131)5.70756867
3Reticulocytopenia (HP:0001896)5.46628438
4Macrocytic anemia (HP:0001972)4.34741737
5Birth length less than 3rd percentile (HP:0003561)4.34364460
6Reduced antithrombin III activity (HP:0001976)3.98128087
7Breast hypoplasia (HP:0003187)3.87202007
8Pallor (HP:0000980)3.82807590
9Cerebral hypomyelination (HP:0006808)3.71581003
10Oral leukoplakia (HP:0002745)3.54788339
11Hepatocellular necrosis (HP:0001404)3.50336268
12Mitochondrial inheritance (HP:0001427)3.37264268
13Increased hepatocellular lipid droplets (HP:0006565)3.31931272
14Aplastic anemia (HP:0001915)3.31367121
15Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.24928076
16Abnormal protein N-linked glycosylation (HP:0012347)3.24928076
17Abnormal protein glycosylation (HP:0012346)3.24928076
18Abnormal glycosylation (HP:0012345)3.24928076
19Aplasia/Hypoplasia of the sacrum (HP:0008517)3.22835163
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.20609607
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.20609607
22Ragged-red muscle fibers (HP:0003200)3.17048685
23Colon cancer (HP:0003003)3.15884208
24Rough bone trabeculation (HP:0100670)3.13351783
25Increased CSF lactate (HP:0002490)3.09554089
26Acute necrotizing encephalopathy (HP:0006965)3.08732551
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.01722106
28Progressive muscle weakness (HP:0003323)2.98463346
29Increased serum lactate (HP:0002151)2.98152794
30Abnormal mitochondria in muscle tissue (HP:0008316)2.92025444
31Lipid accumulation in hepatocytes (HP:0006561)2.85485154
32Abnormality of the preputium (HP:0100587)2.84592257
33Hepatic necrosis (HP:0002605)2.78548693
34Thoracic kyphosis (HP:0002942)2.73972194
35Microretrognathia (HP:0000308)2.71903518
36Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.71381915
37Horseshoe kidney (HP:0000085)2.70109658
38Exertional dyspnea (HP:0002875)2.67343383
39Self-mutilation (HP:0000742)2.63977994
40Aplasia/Hypoplasia of the patella (HP:0006498)2.63801783
41Absent thumb (HP:0009777)2.63544764
42Patellar aplasia (HP:0006443)2.63358629
43Chromsome breakage (HP:0040012)2.63152300
44Microvesicular hepatic steatosis (HP:0001414)2.57519212
45Chromosomal breakage induced by crosslinking agents (HP:0003221)2.55139234
46Meckel diverticulum (HP:0002245)2.48759635
47Supernumerary spleens (HP:0009799)2.47505753
48Triphalangeal thumb (HP:0001199)2.44559771
49Squamous cell carcinoma (HP:0002860)2.43259540
50Carpal bone hypoplasia (HP:0001498)2.42418078
513-Methylglutaconic aciduria (HP:0003535)2.41814315
52Cerebral edema (HP:0002181)2.41012193
53Asplenia (HP:0001746)2.39128761
54Hypertensive crisis (HP:0100735)2.38660694
55Increased intramyocellular lipid droplets (HP:0012240)2.38315395
56Panhypogammaglobulinemia (HP:0003139)2.35309291
57Abnormality of the ileum (HP:0001549)2.34998166
58CNS hypomyelination (HP:0003429)2.34341786
59Acute encephalopathy (HP:0006846)2.31862701
60Trismus (HP:0000211)2.31543961
61Pancytopenia (HP:0001876)2.31539953
62Abnormality of reticulocytes (HP:0004312)2.31306833
63Secondary amenorrhea (HP:0000869)2.29198344
64Abnormality of DNA repair (HP:0003254)2.28100955
65Proximal placement of thumb (HP:0009623)2.28014866
66Selective tooth agenesis (HP:0001592)2.27919770
67Abnormal trabecular bone morphology (HP:0100671)2.27020854
68Impulsivity (HP:0100710)2.26961640
6911 pairs of ribs (HP:0000878)2.26638863
70Progressive macrocephaly (HP:0004481)2.25885351
71Abnormal pupillary function (HP:0007686)2.25059224
72Renal Fanconi syndrome (HP:0001994)2.24767318
73Facial hemangioma (HP:0000329)2.23461918
74Hypoplasia of the radius (HP:0002984)2.23322233
75Chronic obstructive pulmonary disease (HP:0006510)2.23052446
76Obstructive lung disease (HP:0006536)2.23052446
77Respiratory difficulties (HP:0002880)2.22732002
78Premature graying of hair (HP:0002216)2.22158388
79Aplasia/Hypoplasia of the spleen (HP:0010451)2.16562977
80Abnormality of the heme biosynthetic pathway (HP:0010472)2.16021324
81Abnormality of chromosome stability (HP:0003220)2.14457324
82Concave nail (HP:0001598)2.13607520
83Cleft eyelid (HP:0000625)2.12475823
84Severe visual impairment (HP:0001141)2.12384671
85Agammaglobulinemia (HP:0004432)2.12379784
86Absent radius (HP:0003974)2.12244558
87Poikiloderma (HP:0001029)2.12122602
88Aplasia/Hypoplasia of the uvula (HP:0010293)2.10846294
89Mediastinal lymphadenopathy (HP:0100721)2.06929860
90Bone marrow hypocellularity (HP:0005528)2.06273233
91Lactic acidosis (HP:0003128)2.06030925
92Testicular atrophy (HP:0000029)2.05175722
93Premature ovarian failure (HP:0008209)2.05139800
94Ependymoma (HP:0002888)2.03541362
95Myopathic facies (HP:0002058)2.03400365
96Myelodysplasia (HP:0002863)2.03071946
97Absent forearm bone (HP:0003953)2.03046630
98Aplasia involving forearm bones (HP:0009822)2.03046630
99Cholecystitis (HP:0001082)2.02866946
100Abnormal gallbladder physiology (HP:0012438)2.02866946
101Abnormality of the columella (HP:0009929)2.01997058
102Entropion (HP:0000621)2.01762984
103IgM deficiency (HP:0002850)2.00914084
104IgG deficiency (HP:0004315)2.00129490
105Medulloblastoma (HP:0002885)2.00078852
106Abnormality of the thoracic spine (HP:0100711)1.98296873
107Neoplasm of the pancreas (HP:0002894)1.98089847
108Cellular immunodeficiency (HP:0005374)1.97539377
109Rhabdomyosarcoma (HP:0002859)1.95162140
110Abnormality of T cell physiology (HP:0011840)1.94505735
111Respiratory failure (HP:0002878)1.93317203
112Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.93218417
113Increased IgM level (HP:0003496)1.91449263
114Type I transferrin isoform profile (HP:0003642)1.90912214
115Exercise intolerance (HP:0003546)1.90438394
116Emotional lability (HP:0000712)1.90057259
117Abnormal lung lobation (HP:0002101)1.89844528
118Abnormal hemoglobin (HP:0011902)1.89671839
119Hypoplasia of the capital femoral epiphysis (HP:0003090)1.88989585
120Truncus arteriosus (HP:0001660)1.88262803
121Deviation of the thumb (HP:0009603)1.88031330
122Progressive external ophthalmoplegia (HP:0000590)1.86952670
123Dicarboxylic aciduria (HP:0003215)1.86867327
124Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86867327
125Increased serum pyruvate (HP:0003542)1.86769937
126Abnormality of glycolysis (HP:0004366)1.86769937
127Aplasia/hypoplasia of the uterus (HP:0008684)1.85854995
128Small intestinal stenosis (HP:0012848)1.84849831
129Duodenal stenosis (HP:0100867)1.84849831
130Increased muscle lipid content (HP:0009058)1.84395368
131Seborrheic dermatitis (HP:0001051)1.83194828
132Hyperthyroidism (HP:0000836)1.81557396
133Duplicated collecting system (HP:0000081)1.81262877
134Thrombocytosis (HP:0001894)1.81219413
135Gastrointestinal inflammation (HP:0004386)1.80971752
136Aplasia/Hypoplasia of the thymus (HP:0010515)1.80481333
137Sparse eyelashes (HP:0000653)1.80124856
138CNS demyelination (HP:0007305)1.80073957
139Tracheoesophageal fistula (HP:0002575)1.76083612
140Multiple enchondromatosis (HP:0005701)1.74157680
141Lymphoma (HP:0002665)1.74069355
142Recurrent bacterial skin infections (HP:0005406)1.72065680
143Absent rod-and cone-mediated responses on ERG (HP:0007688)1.71679887
144Death in infancy (HP:0001522)1.71454137
145Colitis (HP:0002583)1.67708958
146Pustule (HP:0200039)1.67572226
147Spastic paraparesis (HP:0002313)1.67156462
148Hepatosplenomegaly (HP:0001433)1.66603800
149Elevated erythrocyte sedimentation rate (HP:0003565)1.65809579

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.10054681
2TLK14.18324851
3VRK24.16722008
4NME24.09663425
5WEE13.73248045
6EIF2AK13.71306152
7SMG13.60635786
8STK163.31874497
9SRPK13.28397452
10CDC72.90054285
11ERN12.28524758
12MKNK12.25647062
13MKNK22.24193014
14VRK12.23805263
15TSSK62.09510785
16DYRK32.07839312
17NEK21.76896756
18PRPF4B1.69926282
19PLK11.64143035
20TAF11.63677701
21BRSK21.62567356
22CDK71.60692283
23TRIB31.57099884
24TTK1.55386393
25PLK41.54262802
26NME11.43081568
27CDK191.37889703
28CCNB11.36793727
29GRK61.35996005
30AURKA1.32702059
31PIM21.31012116
32DAPK11.28345578
33AURKB1.27431933
34MAP3K101.25825732
35IRAK31.21448454
36TESK21.20022025
37BLK1.19698599
38PBK1.16992964
39CDK81.16860222
40TBK11.16025246
41ARAF1.15272735
42EIF2AK31.14879153
43PASK1.14651950
44MAP4K11.12041772
45CHEK21.11111324
46ATR1.10800855
47PLK31.08455475
48TESK11.05842755
49MAP3K111.02385754
50BRAF1.01429059
51DYRK21.01025184
52BRSK10.99231098
53ACVR1B0.98656580
54ZAK0.97294382
55CSNK1G30.95541933
56RPS6KB20.88720638
57CSNK1G10.86835273
58PNCK0.84581915
59MATK0.84241887
60CSNK2A20.83704958
61NLK0.83083543
62MAP3K80.80571384
63MUSK0.79443595
64CDK40.79166638
65RPS6KA50.78927946
66CHEK10.76939069
67DAPK30.74353686
68RPS6KA40.74074632
69IKBKB0.73476844
70ABL20.73126010
71CSNK2A10.70446109
72PRKCI0.70185834
73PAK10.69395351
74MAP2K20.68680537
75NUAK10.68075106
76BCKDK0.67735927
77PDK20.66303362
78SIK10.65716208
79IRAK40.65090149
80JAK30.65075324
81BTK0.64865055
82* CDK20.59853748
83RPS6KC10.59111580
84RPS6KL10.59111580
85TNIK0.58647703
86TEC0.58137812
87EIF2AK20.57054576
88BMX0.56967302
89TNK20.55360288
90CASK0.53738566
91YES10.53655014
92SCYL20.53261601
93IRAK10.53077709
94RIPK40.53009635
95ICK0.52750148
96WNK30.52494727
97MELK0.49684107
98MAP2K30.49312147
99ATM0.48797793
100RPS6KA60.48129121
101CSNK1E0.48069582
102PIM10.47526177
103SIK20.46623092
104CSNK1A1L0.46217351
105MAPKAPK50.45726285
106KDR0.45044957
107MAPK110.44220249
108MARK30.44136740
109EEF2K0.43836498
110STK40.43754803
111CDK10.43638894
112TYK20.42731362
113LRRK20.41499571
114STK100.41430868
115TGFBR10.40988044
116CSF1R0.40669369
117KIT0.40289235
118MAP4K20.39148520
119ALK0.38582009
120ILK0.37107701
121EPHA20.35754788
122GRK10.34556845
123ADRBK20.32877341
124TXK0.31644181
125ZAP700.30055543
126STK390.29742025
127LYN0.29075244
128AKT20.28326493
129TAOK20.27520979
130PAK40.27409233
131CLK10.24322336
132CDK30.23990494
133MAPK40.23936673
134CSNK1G20.23599316
135NEK10.23196303

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.38636864
2DNA replication_Homo sapiens_hsa030304.41827042
3RNA polymerase_Homo sapiens_hsa030204.10485376
4Mismatch repair_Homo sapiens_hsa034304.04229524
5Proteasome_Homo sapiens_hsa030503.76757189
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.66761266
7Spliceosome_Homo sapiens_hsa030403.39991898
8Homologous recombination_Homo sapiens_hsa034403.12154410
9Base excision repair_Homo sapiens_hsa034102.77387857
10Pyrimidine metabolism_Homo sapiens_hsa002402.71509789
11RNA transport_Homo sapiens_hsa030132.61225290
12Nucleotide excision repair_Homo sapiens_hsa034202.58473206
13Fanconi anemia pathway_Homo sapiens_hsa034602.32634207
14Basal transcription factors_Homo sapiens_hsa030222.17030924
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.01860227
16Cell cycle_Homo sapiens_hsa041102.01149762
17One carbon pool by folate_Homo sapiens_hsa006701.92993548
18Parkinsons disease_Homo sapiens_hsa050121.80182171
19Oxidative phosphorylation_Homo sapiens_hsa001901.80069118
20RNA degradation_Homo sapiens_hsa030181.76250411
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.72306848
22Non-homologous end-joining_Homo sapiens_hsa034501.59794122
23Huntingtons disease_Homo sapiens_hsa050161.51344763
24Protein export_Homo sapiens_hsa030601.51326377
25Purine metabolism_Homo sapiens_hsa002301.50972770
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46231366
27Sulfur relay system_Homo sapiens_hsa041221.44759124
28mRNA surveillance pathway_Homo sapiens_hsa030151.33466556
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.24030242
30Folate biosynthesis_Homo sapiens_hsa007901.17901697
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14020965
32Vitamin B6 metabolism_Homo sapiens_hsa007501.12581152
33p53 signaling pathway_Homo sapiens_hsa041151.05750673
34Epstein-Barr virus infection_Homo sapiens_hsa051691.02131450
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01892843
36Alzheimers disease_Homo sapiens_hsa050101.01058072
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96791578
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95103852
39Cysteine and methionine metabolism_Homo sapiens_hsa002700.93345555
40Pyruvate metabolism_Homo sapiens_hsa006200.92643997
41Pentose phosphate pathway_Homo sapiens_hsa000300.89042684
42Systemic lupus erythematosus_Homo sapiens_hsa053220.79499735
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79145018
44Shigellosis_Homo sapiens_hsa051310.73271435
45Allograft rejection_Homo sapiens_hsa053300.72574522
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71865401
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.69881608
48Primary immunodeficiency_Homo sapiens_hsa053400.69702507
49Autoimmune thyroid disease_Homo sapiens_hsa053200.68636740
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65820384
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65689871
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.64790422
53Glutathione metabolism_Homo sapiens_hsa004800.59799630
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58609259
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57841517
56Graft-versus-host disease_Homo sapiens_hsa053320.57709854
57Herpes simplex infection_Homo sapiens_hsa051680.57154458
58B cell receptor signaling pathway_Homo sapiens_hsa046620.57070267
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56915737
60Oocyte meiosis_Homo sapiens_hsa041140.56538349
61Metabolic pathways_Homo sapiens_hsa011000.52177570
62Arachidonic acid metabolism_Homo sapiens_hsa005900.51738354
63Viral myocarditis_Homo sapiens_hsa054160.50732234
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49010490
65Regulation of autophagy_Homo sapiens_hsa041400.44821196
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41707001
67Cardiac muscle contraction_Homo sapiens_hsa042600.41686739
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39575750
69Sphingolipid metabolism_Homo sapiens_hsa006000.39376224
70HTLV-I infection_Homo sapiens_hsa051660.38858212
71Bladder cancer_Homo sapiens_hsa052190.38676470
72Viral carcinogenesis_Homo sapiens_hsa052030.36506341
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32988211
74Linoleic acid metabolism_Homo sapiens_hsa005910.32895570
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.32562386
76Fatty acid elongation_Homo sapiens_hsa000620.31845261
77Legionellosis_Homo sapiens_hsa051340.31079157
78Biosynthesis of amino acids_Homo sapiens_hsa012300.30202485
79Antigen processing and presentation_Homo sapiens_hsa046120.29390214
80Vibrio cholerae infection_Homo sapiens_hsa051100.28259045
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27905809
82Type I diabetes mellitus_Homo sapiens_hsa049400.25454870
83Selenocompound metabolism_Homo sapiens_hsa004500.25356312
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24129657
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.23856849
86Leishmaniasis_Homo sapiens_hsa051400.23803521
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.23631551
88Acute myeloid leukemia_Homo sapiens_hsa052210.23352866
89Thyroid cancer_Homo sapiens_hsa052160.22597939
90Basal cell carcinoma_Homo sapiens_hsa052170.22361130
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22294250
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22255224
93Other glycan degradation_Homo sapiens_hsa005110.22143760
94Alcoholism_Homo sapiens_hsa050340.21000958
95N-Glycan biosynthesis_Homo sapiens_hsa005100.19989149
96Arginine and proline metabolism_Homo sapiens_hsa003300.17260236
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16453169
98Ether lipid metabolism_Homo sapiens_hsa005650.16247048
99Phototransduction_Homo sapiens_hsa047440.14384069
100Measles_Homo sapiens_hsa051620.14364002
101Hematopoietic cell lineage_Homo sapiens_hsa046400.11660886
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11533235
103Galactose metabolism_Homo sapiens_hsa000520.09860878
104MicroRNAs in cancer_Homo sapiens_hsa052060.08984272
105Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.08958208
106Notch signaling pathway_Homo sapiens_hsa043300.08871384
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.07851024
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.07661688
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.06156375
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.05745473
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.05592939
112Carbon metabolism_Homo sapiens_hsa012000.05412482
113Colorectal cancer_Homo sapiens_hsa052100.05268827
114Fructose and mannose metabolism_Homo sapiens_hsa000510.05210375
115Wnt signaling pathway_Homo sapiens_hsa043100.03784732
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.03639239
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.02952833
118Pathways in cancer_Homo sapiens_hsa052000.01976635
119Hepatitis B_Homo sapiens_hsa051610.01922801
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.01910753
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.01496740
122Asthma_Homo sapiens_hsa053100.01382002
123Vitamin digestion and absorption_Homo sapiens_hsa049770.00996583
124Apoptosis_Homo sapiens_hsa042100.00208918

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