NSUN5P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents a transcribed pseudogene of a nearby locus on chromosome 7, which encodes a putative methyltransferase. There is also a third closely related pseudogene locus in this region. There is extensive alternative splicing at this locus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.32400122
2translational termination (GO:0006415)7.00568056
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.62632894
4ribosomal small subunit biogenesis (GO:0042274)6.37815940
5ATP synthesis coupled proton transport (GO:0015986)6.08595313
6energy coupled proton transport, down electrochemical gradient (GO:0015985)6.08595313
7ribosomal small subunit assembly (GO:0000028)6.04108237
8translational elongation (GO:0006414)5.86383942
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.83473646
10cotranslational protein targeting to membrane (GO:0006613)5.79803960
11establishment of protein localization to mitochondrial membrane (GO:0090151)5.79538441
12protein targeting to ER (GO:0045047)5.71712854
13establishment of protein localization to endoplasmic reticulum (GO:0072599)5.46302121
14chaperone-mediated protein transport (GO:0072321)5.40742724
15maturation of SSU-rRNA (GO:0030490)5.37029546
16protein localization to endoplasmic reticulum (GO:0070972)5.35254241
17cellular protein complex disassembly (GO:0043624)5.32258704
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.29081825
19viral life cycle (GO:0019058)5.26957465
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.11216240
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.00053724
22mitochondrial respiratory chain complex I assembly (GO:0032981)5.00053724
23NADH dehydrogenase complex assembly (GO:0010257)5.00053724
24protein complex biogenesis (GO:0070271)4.96859853
25respiratory electron transport chain (GO:0022904)4.79470662
26electron transport chain (GO:0022900)4.75311811
27translational initiation (GO:0006413)4.64994095
28mitochondrial respiratory chain complex assembly (GO:0033108)4.64304135
29protein complex disassembly (GO:0043241)4.56170109
30macromolecular complex disassembly (GO:0032984)4.30737292
31ribosomal large subunit biogenesis (GO:0042273)4.26861373
32behavioral response to nicotine (GO:0035095)4.13221645
33translation (GO:0006412)3.88456740
34protein neddylation (GO:0045116)3.73981113
35regulation of mitochondrial translation (GO:0070129)3.72658958
36nuclear-transcribed mRNA catabolic process (GO:0000956)3.72159729
37protein targeting to membrane (GO:0006612)3.70355085
38pseudouridine synthesis (GO:0001522)3.64942233
39transcription elongation from RNA polymerase III promoter (GO:0006385)3.57999231
40termination of RNA polymerase III transcription (GO:0006386)3.57999231
41mRNA catabolic process (GO:0006402)3.55587688
42cellular component biogenesis (GO:0044085)3.53367520
43pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.42999284
44water-soluble vitamin biosynthetic process (GO:0042364)3.36902742
45cytochrome complex assembly (GO:0017004)3.36515541
46ATP biosynthetic process (GO:0006754)3.36488581
47hydrogen ion transmembrane transport (GO:1902600)3.30737919
48respiratory chain complex IV assembly (GO:0008535)3.29849771
49nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.28225232
50exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.27401714
51ribonucleoprotein complex biogenesis (GO:0022613)3.26931483
52RNA catabolic process (GO:0006401)3.26482811
53protein-cofactor linkage (GO:0018065)3.24434349
54purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.22642119
55purine nucleoside triphosphate biosynthetic process (GO:0009145)3.19058929
56regulation of nuclear cell cycle DNA replication (GO:0033262)3.07225942
57intracellular protein transmembrane import (GO:0044743)3.03765677
58establishment of protein localization to mitochondrion (GO:0072655)2.99834856
59chromatin remodeling at centromere (GO:0031055)2.97464358
60pyrimidine nucleotide catabolic process (GO:0006244)2.96084766
61proton transport (GO:0015992)2.95806864
62protein targeting to mitochondrion (GO:0006626)2.94386085
63negative regulation of telomere maintenance (GO:0032205)2.93793491
64DNA deamination (GO:0045006)2.92811729
65rRNA processing (GO:0006364)2.91982196
66hydrogen transport (GO:0006818)2.90203138
67DNA damage response, detection of DNA damage (GO:0042769)2.89815496
68ribonucleoside triphosphate biosynthetic process (GO:0009201)2.87631888
69rRNA metabolic process (GO:0016072)2.86104234
70base-excision repair, AP site formation (GO:0006285)2.84307571
71GTP biosynthetic process (GO:0006183)2.78794988
72rRNA modification (GO:0000154)2.77844829
73protein localization to mitochondrion (GO:0070585)2.76869397
74epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.76505930
75tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.76502075
76RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.76502075
77CENP-A containing nucleosome assembly (GO:0034080)2.67392278
78tRNA processing (GO:0008033)2.66900751
79protein targeting (GO:0006605)2.64328764
80DNA replication checkpoint (GO:0000076)2.62767777
81somite development (GO:0061053)2.62160126
82mitochondrial transport (GO:0006839)2.58704310
83spliceosomal snRNP assembly (GO:0000387)2.57674546
84inner mitochondrial membrane organization (GO:0007007)2.56471653
85establishment of protein localization to membrane (GO:0090150)2.55000281
86kinetochore assembly (GO:0051382)2.54159917
87epithelial cilium movement (GO:0003351)2.53907349
88nephron tubule morphogenesis (GO:0072078)2.53206720
89nephron epithelium morphogenesis (GO:0072088)2.53206720
90establishment of protein localization to organelle (GO:0072594)2.51525649
91neuron fate determination (GO:0048664)2.48973274
92proteasome assembly (GO:0043248)2.48088185
93nucleoside triphosphate biosynthetic process (GO:0009142)2.48006638
94regulation of mitotic spindle checkpoint (GO:1903504)2.47052373
95regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.47052373
96nonmotile primary cilium assembly (GO:0035058)2.44965314
97intracellular protein transmembrane transport (GO:0065002)2.44907025
98spliceosomal complex assembly (GO:0000245)2.43217664
99otic vesicle formation (GO:0030916)2.42498538
100UTP biosynthetic process (GO:0006228)2.40308934

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.48741513
2EZH2_22144423_ChIP-Seq_EOC_Human3.92874655
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.78570634
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.46963541
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.36291619
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.28507842
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.08645615
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.02792979
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.97831426
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.78581472
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.73133554
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.58447989
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.37926451
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24761192
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.20416242
16XRN2_22483619_ChIP-Seq_HELA_Human2.04624449
17ZNF274_21170338_ChIP-Seq_K562_Hela2.04258732
18MYC_18940864_ChIP-ChIP_HL60_Human2.02392950
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00978860
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00016184
21MYC_18358816_ChIP-ChIP_MESCs_Mouse1.99185328
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.95049522
23TTF2_22483619_ChIP-Seq_HELA_Human1.94869579
24* VDR_23849224_ChIP-Seq_CD4+_Human1.93195892
25CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.78084769
26FOXP3_21729870_ChIP-Seq_TREG_Human1.71520747
27YY1_21170310_ChIP-Seq_MESCs_Mouse1.67096100
28THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65493627
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61585990
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.61459545
31GABP_19822575_ChIP-Seq_HepG2_Human1.61066728
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.58933999
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.56642518
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49654494
35ELK1_19687146_ChIP-ChIP_HELA_Human1.47109881
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.46381336
37POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41180790
38VDR_22108803_ChIP-Seq_LS180_Human1.41159306
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.36712160
40POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34320543
41EWS_26573619_Chip-Seq_HEK293_Human1.33526825
42SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.29545405
43CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29038892
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26550105
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.26305590
46EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.24837398
47DCP1A_22483619_ChIP-Seq_HELA_Human1.18790331
48REST_21632747_ChIP-Seq_MESCs_Mouse1.18585218
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.18195856
50IRF1_19129219_ChIP-ChIP_H3396_Human1.18017029
51FUS_26573619_Chip-Seq_HEK293_Human1.17866958
52SOX2_16153702_ChIP-ChIP_HESCs_Human1.17368994
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14948275
54RNF2_27304074_Chip-Seq_NSC_Mouse1.14924207
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.14822894
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13453489
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12731590
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12486353
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11483608
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11397624
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.11026108
62KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10778190
63JARID2_20064375_ChIP-Seq_MESCs_Mouse1.10224932
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09188552
65EED_16625203_ChIP-ChIP_MESCs_Mouse1.08874277
66TP53_22573176_ChIP-Seq_HFKS_Human1.07498509
67E2F4_17652178_ChIP-ChIP_JURKAT_Human1.07447272
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06585610
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06490616
70RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06065490
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05566394
72FOXP1_21924763_ChIP-Seq_HESCs_Human1.05220143
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04605843
74ERA_21632823_ChIP-Seq_H3396_Human1.03099624
75YY1_22570637_ChIP-Seq_MALME-3M_Human1.02588864
76RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01186850
77NANOG_20526341_ChIP-Seq_ESCs_Human1.01104586
78* KDM5A_27292631_Chip-Seq_BREAST_Human1.00762600
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98644139
80JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97226915
81SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95579312
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95013755
83REST_18959480_ChIP-ChIP_MESCs_Mouse0.94634328
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94116948
85CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93847746
86CTCF_20526341_ChIP-Seq_ESCs_Human0.92778392
87IGF1R_20145208_ChIP-Seq_DFB_Human0.91950133
88ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91356595
89P53_21459846_ChIP-Seq_SAOS-2_Human0.91219842
90SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91121310
91FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.90187949
92POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89099252
93GATA3_21878914_ChIP-Seq_MCF-7_Human0.88942448
94TAF2_19829295_ChIP-Seq_ESCs_Human0.87283323
95CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86132517
96NCOR_22424771_ChIP-Seq_293T_Human0.85722163
97RBPJ_22232070_ChIP-Seq_NCS_Mouse0.84599562
98PHF8_20622854_ChIP-Seq_HELA_Human0.84052212
99E2F1_20622854_ChIP-Seq_HELA_Human0.83181777
100CTCF_27219007_Chip-Seq_Bcells_Human0.82709873

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.27375840
2MP0006292_abnormal_olfactory_placode4.33678240
3MP0003136_yellow_coat_color3.10858919
4MP0002653_abnormal_ependyma_morphology2.47509444
5MP0001188_hyperpigmentation2.14880153
6MP0003787_abnormal_imprinting2.07705326
7MP0004142_abnormal_muscle_tone2.02877567
8MP0001529_abnormal_vocalization1.95550944
9MP0003880_abnormal_central_pattern1.93432305
10MP0008877_abnormal_DNA_methylation1.91915421
11MP0002277_abnormal_respiratory_mucosa1.87538077
12MP0000049_abnormal_middle_ear1.86319988
13MP0004133_heterotaxia1.85465778
14MP0002638_abnormal_pupillary_reflex1.80020493
15MP0002102_abnormal_ear_morphology1.76028856
16MP0002938_white_spotting1.75804872
17MP0008058_abnormal_DNA_repair1.75272355
18MP0004885_abnormal_endolymph1.71829029
19MP0003122_maternal_imprinting1.71396844
20MP0006072_abnormal_retinal_apoptosis1.64706340
21MP0001968_abnormal_touch/_nociception1.64129203
22MP0000631_abnormal_neuroendocrine_gland1.61986555
23MP0001905_abnormal_dopamine_level1.59385445
24MP0008789_abnormal_olfactory_epithelium1.57174738
25MP0001485_abnormal_pinna_reflex1.56398354
26MP0005084_abnormal_gallbladder_morpholo1.53851436
27MP0003121_genomic_imprinting1.52783238
28MP0001293_anophthalmia1.52026779
29MP0005423_abnormal_somatic_nervous1.50576686
30MP0006276_abnormal_autonomic_nervous1.49669685
31MP0005551_abnormal_eye_electrophysiolog1.49191500
32MP0004742_abnormal_vestibular_system1.47652608
33MP0002272_abnormal_nervous_system1.44751235
34MP0002736_abnormal_nociception_after1.44705423
35MP0002163_abnormal_gland_morphology1.39069620
36MP0009745_abnormal_behavioral_response1.38659507
37MP0001986_abnormal_taste_sensitivity1.38595625
38MP0000566_synostosis1.36338640
39MP0000026_abnormal_inner_ear1.35071210
40MP0003011_delayed_dark_adaptation1.33609697
41MP0008995_early_reproductive_senescence1.32772689
42MP0003938_abnormal_ear_development1.31792872
43MP0003878_abnormal_ear_physiology1.30175214
44MP0005377_hearing/vestibular/ear_phenot1.30175214
45MP0002160_abnormal_reproductive_system1.25143175
46MP0000778_abnormal_nervous_system1.20320994
47MP0001486_abnormal_startle_reflex1.18860114
48MP0005499_abnormal_olfactory_system1.18358733
49MP0005394_taste/olfaction_phenotype1.18358733
50MP0003718_maternal_effect1.17654533
51MP0009046_muscle_twitch1.16840207
52MP0010030_abnormal_orbit_morphology1.16165054
53MP0003123_paternal_imprinting1.14877354
54MP0002837_dystrophic_cardiac_calcinosis1.11505234
55MP0008875_abnormal_xenobiotic_pharmacok1.11427292
56MP0003693_abnormal_embryo_hatching1.08386538
57MP0002822_catalepsy1.08081632
58MP0005389_reproductive_system_phenotype1.07613451
59MP0004019_abnormal_vitamin_homeostasis1.06996977
60MP0003283_abnormal_digestive_organ1.06361284
61MP0005195_abnormal_posterior_eye1.05470672
62MP0002752_abnormal_somatic_nervous1.04879276
63MP0002095_abnormal_skin_pigmentation1.04493873
64MP0002572_abnormal_emotion/affect_behav1.03465431
65MP0001764_abnormal_homeostasis1.03055955
66MP0002064_seizures1.02904108
67MP0001970_abnormal_pain_threshold1.02700372
68MP0002557_abnormal_social/conspecific_i1.02386298
69MP0005645_abnormal_hypothalamus_physiol1.02361297
70MP0003567_abnormal_fetal_cardiomyocyte1.02055363
71MP0002928_abnormal_bile_duct1.01942964
72MP0001963_abnormal_hearing_physiology1.01714416
73MP0001286_abnormal_eye_development1.01414107
74MP0002735_abnormal_chemical_nociception1.01381060
75MP0006036_abnormal_mitochondrial_physio1.01352452
76MP0005646_abnormal_pituitary_gland1.01056258
77MP0001919_abnormal_reproductive_system0.99657999
78MP0003806_abnormal_nucleotide_metabolis0.99518954
79MP0002210_abnormal_sex_determination0.98874719
80MP0003635_abnormal_synaptic_transmissio0.98484323
81MP0003186_abnormal_redox_activity0.96875664
82MP0002733_abnormal_thermal_nociception0.96585394
83MP0001502_abnormal_circadian_rhythm0.96425144
84MP0008872_abnormal_physiological_respon0.94986495
85MP0005174_abnormal_tail_pigmentation0.94941043
86MP0001984_abnormal_olfaction0.91363804
87MP0000372_irregular_coat_pigmentation0.91048216
88MP0000955_abnormal_spinal_cord0.89823642
89MP0003315_abnormal_perineum_morphology0.87210246
90MP0002067_abnormal_sensory_capabilities0.84489228
91MP0006035_abnormal_mitochondrial_morpho0.81740120
92MP0001145_abnormal_male_reproductive0.81564009
93MP0001440_abnormal_grooming_behavior0.80590685
94MP0005379_endocrine/exocrine_gland_phen0.79464586
95MP0004147_increased_porphyrin_level0.78374363
96MP0002063_abnormal_learning/memory/cond0.77889191
97MP0002184_abnormal_innervation0.77672656
98MP0003698_abnormal_male_reproductive0.76839576
99MP0003890_abnormal_embryonic-extraembry0.75466097
100MP0005253_abnormal_eye_physiology0.75458510

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.76603063
2Abnormal number of erythroid precursors (HP:0012131)4.65777637
3Reticulocytopenia (HP:0001896)4.36751890
4Acute necrotizing encephalopathy (HP:0006965)4.34222065
5Macrocytic anemia (HP:0001972)3.98255813
6Mitochondrial inheritance (HP:0001427)3.93633160
7Abnormal mitochondria in muscle tissue (HP:0008316)3.87183321
8Acute encephalopathy (HP:0006846)3.66629893
9Molar tooth sign on MRI (HP:0002419)3.48829113
10Abnormality of midbrain morphology (HP:0002418)3.48829113
11Progressive macrocephaly (HP:0004481)3.43609404
12Increased CSF lactate (HP:0002490)3.36392656
133-Methylglutaconic aciduria (HP:0003535)3.31851594
14Increased hepatocellular lipid droplets (HP:0006565)3.30253692
15Hepatocellular necrosis (HP:0001404)3.24600666
16Pallor (HP:0000980)3.22934756
17Septo-optic dysplasia (HP:0100842)3.15705970
18Pancreatic cysts (HP:0001737)3.12002902
19Nephronophthisis (HP:0000090)3.07586671
20Pancreatic fibrosis (HP:0100732)3.07331810
21Lipid accumulation in hepatocytes (HP:0006561)2.96413797
22True hermaphroditism (HP:0010459)2.94990546
23Hepatic necrosis (HP:0002605)2.87248940
24Rib fusion (HP:0000902)2.72060681
25Renal Fanconi syndrome (HP:0001994)2.68029505
26Abnormal rod and cone electroretinograms (HP:0008323)2.61368764
27Cerebral edema (HP:0002181)2.60387348
28Congenital stationary night blindness (HP:0007642)2.55563369
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.53154426
30Decreased activity of mitochondrial respiratory chain (HP:0008972)2.53154426
31Medial flaring of the eyebrow (HP:0010747)2.51674757
32Pendular nystagmus (HP:0012043)2.51352537
33Abnormality of the renal medulla (HP:0100957)2.50872449
34Congenital, generalized hypertrichosis (HP:0004540)2.46681981
35Myokymia (HP:0002411)2.45327563
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.43242238
37Optic disc pallor (HP:0000543)2.42297429
38Anophthalmia (HP:0000528)2.37466569
39Absent rod-and cone-mediated responses on ERG (HP:0007688)2.36757632
40Exertional dyspnea (HP:0002875)2.29406139
41Concave nail (HP:0001598)2.27934945
42Increased intramyocellular lipid droplets (HP:0012240)2.25557204
43Methylmalonic acidemia (HP:0002912)2.21848776
44Absent thumb (HP:0009777)2.18829021
45Lactic acidosis (HP:0003128)2.18292265
46Bilateral microphthalmos (HP:0007633)2.18159825
47Increased serum lactate (HP:0002151)2.17795198
48Methylmalonic aciduria (HP:0012120)2.17527585
49Aplasia/Hypoplasia of the sacrum (HP:0008517)2.12702935
50Abnormal number of incisors (HP:0011064)2.11855246
51Gait imbalance (HP:0002141)2.11751446
52Sclerocornea (HP:0000647)2.10172298
53Nephrogenic diabetes insipidus (HP:0009806)2.07918778
54Maternal diabetes (HP:0009800)2.05058404
55Type II lissencephaly (HP:0007260)2.03683705
56Congenital primary aphakia (HP:0007707)2.00595232
57Colon cancer (HP:0003003)1.99246716
58Respiratory difficulties (HP:0002880)1.99161923
59Male pseudohermaphroditism (HP:0000037)1.98568502
60Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96491872
61Abolished electroretinogram (ERG) (HP:0000550)1.96453406
62Abnormality of the labia minora (HP:0012880)1.95996321
63Abnormality of renal resorption (HP:0011038)1.95035888
64Hyperglycinemia (HP:0002154)1.93196923
65Anencephaly (HP:0002323)1.92912218
66Optic nerve coloboma (HP:0000588)1.92165794
67Bile duct proliferation (HP:0001408)1.90743151
68Abnormal biliary tract physiology (HP:0012439)1.90743151
6911 pairs of ribs (HP:0000878)1.89604222
70Optic nerve hypoplasia (HP:0000609)1.89061900
71Leukodystrophy (HP:0002415)1.88041705
72Increased muscle lipid content (HP:0009058)1.86635765
73Lethargy (HP:0001254)1.85222376
74Respiratory failure (HP:0002878)1.84867373
75Polydipsia (HP:0001959)1.84862329
76Abnormal drinking behavior (HP:0030082)1.84862329
77Esophageal atresia (HP:0002032)1.83566806
78Severe visual impairment (HP:0001141)1.82084242
79Cystic liver disease (HP:0006706)1.79193586
80Absent septum pellucidum (HP:0001331)1.78299266
81Depressed nasal ridge (HP:0000457)1.77080244
82Abnormal respiratory motile cilium morphology (HP:0005938)1.75726531
83Abnormal respiratory epithelium morphology (HP:0012253)1.75726531
84Abnormality of the renal cortex (HP:0011035)1.74347374
85Genital tract atresia (HP:0001827)1.73963921
86Vaginal atresia (HP:0000148)1.73912323
87Stenosis of the external auditory canal (HP:0000402)1.73601421
88Triphalangeal thumb (HP:0001199)1.73244677
89Exercise intolerance (HP:0003546)1.71849546
90Aplasia/Hypoplasia of the spleen (HP:0010451)1.71841917
91Glycosuria (HP:0003076)1.71317010
92Abnormality of urine glucose concentration (HP:0011016)1.71317010
93Homocystinuria (HP:0002156)1.70356895
94Abnormality of homocysteine metabolism (HP:0010919)1.70356895
95Oligodactyly (hands) (HP:0001180)1.69151581
96Hyperglycinuria (HP:0003108)1.68274716
97Bony spicule pigmentary retinopathy (HP:0007737)1.67042808
98Asplenia (HP:0001746)1.67010034
99Progressive microcephaly (HP:0000253)1.65388112
100Hypoplasia of the radius (HP:0002984)1.64691277

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK13.56780562
2PNCK3.15235423
3VRK23.11973268
4MAPK152.96305601
5CDC72.71884629
6STK162.56380397
7DYRK22.51598435
8ZAK2.47032764
9NUAK12.35308005
10WNK42.15300022
11ADRBK22.11781423
12NME12.11111891
13VRK12.03446131
14BCKDK1.98452370
15WNK31.91806250
16BMPR1B1.91363958
17GRK11.87879552
18TNIK1.81661558
19PINK11.75262982
20BUB11.74886554
21TAOK31.70690649
22MAPK131.69246627
23WEE11.69068070
24MAP4K21.57648745
25NME21.47112400
26CASK1.34988899
27DYRK31.30940511
28PRKCG1.29817337
29CDK191.29559179
30NTRK21.28314040
31CDK31.23536332
32TAF11.22039141
33MAP3K101.14985794
34INSRR1.13118205
35PLK41.12303021
36MAP2K61.10087576
37MAP2K71.07857930
38IRAK40.97458205
39MAP3K40.97195912
40MARK10.96351769
41MAPKAPK50.89386548
42PASK0.86645555
43EPHB20.85826113
44PLK10.85656184
45CDK80.85593859
46NEK20.84605223
47CHEK20.84232947
48MAP3K110.82900443
49SIK20.81765962
50MAP2K40.80125008
51SRPK10.77602316
52MARK30.76491261
53TXK0.74908160
54MKNK20.70316702
55BRAF0.69709309
56AURKB0.67535317
57NTRK30.67177932
58TTK0.66796608
59AURKA0.66321733
60ABL20.65587807
61ILK0.63823488
62PLK30.62836814
63CSNK2A20.61590859
64TGFBR10.61240705
65CAMK10.58962118
66GRK70.58914820
67DYRK1A0.58855925
68DYRK1B0.58722715
69PRKCQ0.58309916
70RPS6KA50.57679903
71STK390.57636128
72UHMK10.57096023
73ATR0.56733902
74ADRBK10.55843183
75CSNK2A10.55670363
76PRKCI0.55176903
77MKNK10.54293064
78TEC0.53972018
79CSNK1E0.51695392
80KIT0.50914036
81TYRO30.50489977
82CSNK1G10.49344771
83BRSK10.49201598
84TSSK60.49107922
85PRKACA0.48933414
86CSNK1A10.47872211
87MAPK120.47262251
88RPS6KA60.44502765
89PIM10.40738619
90CSNK1G20.40570274
91MAPKAPK30.40338113
92MATK0.40172640
93IKBKB0.40154196
94TNK20.38722975
95STK110.38317335
96MAP2K20.37339188
97CSNK1G30.37030603
98PDK20.34058844
99DAPK20.33015032
100FRK0.31639975

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.36856576
2Oxidative phosphorylation_Homo sapiens_hsa001904.70645588
3Parkinsons disease_Homo sapiens_hsa050124.02554572
4RNA polymerase_Homo sapiens_hsa030202.88739052
5Huntingtons disease_Homo sapiens_hsa050162.83060691
6Alzheimers disease_Homo sapiens_hsa050102.60507324
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.49546472
8Cardiac muscle contraction_Homo sapiens_hsa042602.33649647
9Homologous recombination_Homo sapiens_hsa034402.30833310
10Sulfur relay system_Homo sapiens_hsa041222.19576168
11Proteasome_Homo sapiens_hsa030502.08337941
12Protein export_Homo sapiens_hsa030602.03224769
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.83454946
14Fanconi anemia pathway_Homo sapiens_hsa034601.78311777
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.74055959
16Spliceosome_Homo sapiens_hsa030401.73726916
17DNA replication_Homo sapiens_hsa030301.66471952
18Base excision repair_Homo sapiens_hsa034101.64604968
19RNA degradation_Homo sapiens_hsa030181.59477150
20Mismatch repair_Homo sapiens_hsa034301.58931991
21Phototransduction_Homo sapiens_hsa047441.49031261
22Pyrimidine metabolism_Homo sapiens_hsa002401.43645693
23Basal transcription factors_Homo sapiens_hsa030221.43078404
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.41297635
25One carbon pool by folate_Homo sapiens_hsa006701.36424093
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36364869
27Linoleic acid metabolism_Homo sapiens_hsa005911.33743156
28Nicotine addiction_Homo sapiens_hsa050331.31132757
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21272897
30Folate biosynthesis_Homo sapiens_hsa007901.19707435
31Nucleotide excision repair_Homo sapiens_hsa034201.17961891
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10415069
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.08900456
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06178231
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05235360
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03808967
37Purine metabolism_Homo sapiens_hsa002300.97558897
38RNA transport_Homo sapiens_hsa030130.97384937
39Selenocompound metabolism_Homo sapiens_hsa004500.96857951
40Vitamin digestion and absorption_Homo sapiens_hsa049770.91295853
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86013852
42Butanoate metabolism_Homo sapiens_hsa006500.84652926
43Basal cell carcinoma_Homo sapiens_hsa052170.82906742
44Fatty acid elongation_Homo sapiens_hsa000620.82526870
45Collecting duct acid secretion_Homo sapiens_hsa049660.82215901
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81891065
47Nitrogen metabolism_Homo sapiens_hsa009100.80165282
48Taste transduction_Homo sapiens_hsa047420.79459247
49Intestinal immune network for IgA production_Homo sapiens_hsa046720.78957979
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75445482
51Regulation of autophagy_Homo sapiens_hsa041400.73372664
52Asthma_Homo sapiens_hsa053100.70869230
53Peroxisome_Homo sapiens_hsa041460.70450557
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70111712
55Metabolic pathways_Homo sapiens_hsa011000.69531850
56Chemical carcinogenesis_Homo sapiens_hsa052040.67570285
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66113947
58Hedgehog signaling pathway_Homo sapiens_hsa043400.64868548
59Primary immunodeficiency_Homo sapiens_hsa053400.61853141
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60939677
61Olfactory transduction_Homo sapiens_hsa047400.60734518
62Ether lipid metabolism_Homo sapiens_hsa005650.60636092
63Arachidonic acid metabolism_Homo sapiens_hsa005900.59457648
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56567975
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55424809
66Retinol metabolism_Homo sapiens_hsa008300.51687388
67Morphine addiction_Homo sapiens_hsa050320.50867222
68Glutathione metabolism_Homo sapiens_hsa004800.48847139
69Fat digestion and absorption_Homo sapiens_hsa049750.46984997
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.46228027
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45408909
72Steroid biosynthesis_Homo sapiens_hsa001000.44037095
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40600285
74Tryptophan metabolism_Homo sapiens_hsa003800.39366181
75GABAergic synapse_Homo sapiens_hsa047270.38528837
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.37844367
77Serotonergic synapse_Homo sapiens_hsa047260.37596475
78Pyruvate metabolism_Homo sapiens_hsa006200.37345735
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.37212806
80Graft-versus-host disease_Homo sapiens_hsa053320.37187988
81Insulin secretion_Homo sapiens_hsa049110.35964010
82Caffeine metabolism_Homo sapiens_hsa002320.34530771
83Cocaine addiction_Homo sapiens_hsa050300.34298780
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34235918
85mRNA surveillance pathway_Homo sapiens_hsa030150.33332335
86Propanoate metabolism_Homo sapiens_hsa006400.33162912
87Glutamatergic synapse_Homo sapiens_hsa047240.32547675
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32173535
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32095542
90Autoimmune thyroid disease_Homo sapiens_hsa053200.31650998
91Allograft rejection_Homo sapiens_hsa053300.30255465
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.29269519
93Type I diabetes mellitus_Homo sapiens_hsa049400.29048197
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26433018
95Non-homologous end-joining_Homo sapiens_hsa034500.24735446
96Antigen processing and presentation_Homo sapiens_hsa046120.24434888
97Glycerolipid metabolism_Homo sapiens_hsa005610.21834831
98Circadian entrainment_Homo sapiens_hsa047130.21359933
99Cell cycle_Homo sapiens_hsa041100.18713559
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.17679779

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »