NSUN7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)7.38360640
2acrosome reaction (GO:0007340)7.34894615
3sperm motility (GO:0030317)7.21724230
4epithelial cilium movement (GO:0003351)7.10841353
5fusion of sperm to egg plasma membrane (GO:0007342)6.74159112
6motile cilium assembly (GO:0044458)6.70899727
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.56233957
8multicellular organism reproduction (GO:0032504)6.55495976
9cilium movement (GO:0003341)6.38108568
10piRNA metabolic process (GO:0034587)6.33166285
11sperm-egg recognition (GO:0035036)5.85039194
12cell wall macromolecule metabolic process (GO:0044036)5.62281956
13cell wall macromolecule catabolic process (GO:0016998)5.62281956
14acrosome assembly (GO:0001675)5.57413223
15plasma membrane fusion (GO:0045026)5.47468377
16microtubule bundle formation (GO:0001578)5.35130435
17male meiosis (GO:0007140)5.32225176
18spermatid development (GO:0007286)5.21599620
19cell-cell recognition (GO:0009988)5.20250740
20binding of sperm to zona pellucida (GO:0007339)5.19692135
21regulation of cilium movement (GO:0003352)4.99610482
22reproduction (GO:0000003)4.93870703
23primary alcohol catabolic process (GO:0034310)4.92670143
24protein localization to cilium (GO:0061512)4.92000136
25DNA methylation involved in gamete generation (GO:0043046)4.91193554
26single fertilization (GO:0007338)4.67932929
27regulation of microtubule-based movement (GO:0060632)4.54748327
28microtubule depolymerization (GO:0007019)4.49354418
29vitamin transmembrane transport (GO:0035461)4.14799820
30microtubule-based movement (GO:0007018)4.09048274
31sperm capacitation (GO:0048240)3.97621211
32establishment of apical/basal cell polarity (GO:0035089)3.96299112
33calcium ion-dependent exocytosis (GO:0017156)3.91449021
34lateral ventricle development (GO:0021670)3.91405429
35synaptonemal complex organization (GO:0070193)3.89774257
36ventricular system development (GO:0021591)3.87793119
37cell projection assembly (GO:0030031)3.86300978
38intra-S DNA damage checkpoint (GO:0031573)3.85394187
39male meiosis I (GO:0007141)3.84035953
40fertilization (GO:0009566)3.83253685
41centriole assembly (GO:0098534)3.82115806
42intraciliary transport (GO:0042073)3.77524516
43microtubule polymerization or depolymerization (GO:0031109)3.71643225
44synaptonemal complex assembly (GO:0007130)3.64892209
45establishment of monopolar cell polarity (GO:0061162)3.63347054
46establishment or maintenance of monopolar cell polarity (GO:0061339)3.63347054
47cilium assembly (GO:0042384)3.62948431
48cilium organization (GO:0044782)3.59355280
49spermatogenesis (GO:0007283)3.57353736
50ethanol metabolic process (GO:0006067)3.57152432
51male gamete generation (GO:0048232)3.56548794
52axoneme assembly (GO:0035082)3.42313922
53diterpenoid biosynthetic process (GO:0016102)3.40071876
54smoothened signaling pathway (GO:0007224)3.38043922
55photoreceptor cell maintenance (GO:0045494)3.37940763
56determination of left/right symmetry (GO:0007368)3.32533808
57chromosome organization involved in meiosis (GO:0070192)3.31986220
58gamete generation (GO:0007276)3.31316396
59cell recognition (GO:0008037)3.30928707
60determination of bilateral symmetry (GO:0009855)3.20284401
61synapsis (GO:0007129)3.18021048
62terpenoid biosynthetic process (GO:0016114)3.16082162
63specification of symmetry (GO:0009799)3.15763708
64lateral sprouting from an epithelium (GO:0060601)3.14626848
65pyrimidine-containing compound transmembrane transport (GO:0072531)3.13216116
66organic cation transport (GO:0015695)3.12590321
67startle response (GO:0001964)3.10500068
68germ cell development (GO:0007281)3.10228913
69left/right pattern formation (GO:0060972)3.10179240
70establishment of tissue polarity (GO:0007164)3.09296033
71establishment of planar polarity (GO:0001736)3.09296033
72glomerular epithelial cell development (GO:0072310)2.99070179
73lung epithelium development (GO:0060428)2.98608968
74regulation of posttranscriptional gene silencing (GO:0060147)2.97789277
75regulation of gene silencing by miRNA (GO:0060964)2.97789277
76regulation of gene silencing by RNA (GO:0060966)2.97789277
77retinoic acid metabolic process (GO:0042573)2.97725226
78ionotropic glutamate receptor signaling pathway (GO:0035235)2.96668726
79response to xenobiotic stimulus (GO:0009410)2.96382573
80negative regulation of inclusion body assembly (GO:0090084)2.95601925
81cilium morphogenesis (GO:0060271)2.91740339
82aldehyde catabolic process (GO:0046185)2.90130614
83retinal rod cell development (GO:0046548)2.89881538
84cellular process involved in reproduction in multicellular organism (GO:0022412)2.89035517
85replicative senescence (GO:0090399)2.88001264
86negative regulation of immunoglobulin mediated immune response (GO:0002890)2.86277864
87negative regulation of B cell mediated immunity (GO:0002713)2.86277864
88auditory receptor cell stereocilium organization (GO:0060088)2.84794138
89superoxide anion generation (GO:0042554)2.84568892
90cellular component assembly involved in morphogenesis (GO:0010927)2.84447029
91meiotic nuclear division (GO:0007126)2.83126724
92glutamate receptor signaling pathway (GO:0007215)2.83036522
93G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.80932138
94meiosis I (GO:0007127)2.80724076
95positive regulation of smoothened signaling pathway (GO:0045880)2.78713551
96negative regulation of T cell differentiation in thymus (GO:0033085)2.77097043
97regulation of collateral sprouting (GO:0048670)2.75705528
98organelle assembly (GO:0070925)2.71515850
99negative regulation of DNA-dependent DNA replication (GO:2000104)2.71439315
100centriole replication (GO:0007099)2.70807851
101carnitine metabolic process (GO:0009437)2.69440788
102phenol-containing compound catabolic process (GO:0019336)2.68908422
103calcium ion import (GO:0070509)2.68542375
104cAMP catabolic process (GO:0006198)2.68248586
105polyketide metabolic process (GO:0030638)2.67106563
106doxorubicin metabolic process (GO:0044598)2.67106563
107daunorubicin metabolic process (GO:0044597)2.67106563
108microtubule-based process (GO:0007017)2.66762891
109regulation of interleukin-5 production (GO:0032674)2.65869211
110embryonic camera-type eye development (GO:0031076)2.65782352
111regulation of acrosome reaction (GO:0060046)2.64884692
112nucleoside diphosphate catabolic process (GO:0009134)2.64575156
113meiotic cell cycle (GO:0051321)2.62869831
114inner ear receptor stereocilium organization (GO:0060122)2.62026995
115heart looping (GO:0001947)2.59341416
116resolution of meiotic recombination intermediates (GO:0000712)2.58935784
117phosphorelay signal transduction system (GO:0000160)2.57439738
118opioid receptor signaling pathway (GO:0038003)2.57235703
119regulation of meiosis I (GO:0060631)2.56962349
120chromatin remodeling at centromere (GO:0031055)2.56449771
121one-carbon compound transport (GO:0019755)2.55890997
122calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.54904535
123multicellular organismal reproductive process (GO:0048609)2.53766227
124microtubule severing (GO:0051013)2.53468244
125thyroid hormone generation (GO:0006590)2.52890461
126cyclic nucleotide catabolic process (GO:0009214)2.51839420
127mesenchymal cell differentiation involved in renal system development (GO:2001012)2.51435985
128mesenchymal cell differentiation involved in kidney development (GO:0072161)2.51435985
129preassembly of GPI anchor in ER membrane (GO:0016254)2.51406699
130otic vesicle formation (GO:0030916)2.50998705
131nonmotile primary cilium assembly (GO:0035058)2.50374564
132sulfate transmembrane transport (GO:1902358)2.48373792
133left/right axis specification (GO:0070986)2.48123122
134synaptic transmission, glutamatergic (GO:0035249)2.47147572
135cytoplasmic microtubule organization (GO:0031122)2.46774976
136nephron tubule morphogenesis (GO:0072078)2.45337802
137nephron epithelium morphogenesis (GO:0072088)2.45337802
138reciprocal DNA recombination (GO:0035825)2.45295424
139reciprocal meiotic recombination (GO:0007131)2.45295424
140DNA synthesis involved in DNA repair (GO:0000731)2.44164330
141ethanol oxidation (GO:0006069)2.44098237
142deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.43604511
143righting reflex (GO:0060013)2.43537469
144histone H2A acetylation (GO:0043968)2.43063502
145poly(A)+ mRNA export from nucleus (GO:0016973)2.42647215
146urinary tract smooth muscle contraction (GO:0014848)2.42497539
147CENP-A containing nucleosome assembly (GO:0034080)2.41228703
148regulation of smoothened signaling pathway (GO:0008589)2.41140775
149positive regulation of CREB transcription factor activity (GO:0032793)2.40630466
150regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.40044154
151transmission of nerve impulse (GO:0019226)2.39365500
152lactate metabolic process (GO:0006089)2.39357050
153protein polyglutamylation (GO:0018095)2.39349871
154nucleoside diphosphate phosphorylation (GO:0006165)2.38621753
155glutathione derivative metabolic process (GO:1901685)2.38229494
156glutathione derivative biosynthetic process (GO:1901687)2.38229494
157hydrogen peroxide catabolic process (GO:0042744)2.36769728
158regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.36752403
159single strand break repair (GO:0000012)2.36401622
160embryonic body morphogenesis (GO:0010172)2.36292445
161apical protein localization (GO:0045176)2.34917028
162embryonic heart tube morphogenesis (GO:0003143)2.34478005
163sulfate transport (GO:0008272)2.34346999
164thyroid hormone metabolic process (GO:0042403)2.33826171
165membrane depolarization during action potential (GO:0086010)2.33713927
166photoreceptor cell differentiation (GO:0046530)2.31200692
167eye photoreceptor cell differentiation (GO:0001754)2.31200692
168retinal cone cell development (GO:0046549)2.30736382
169cilium or flagellum-dependent cell motility (GO:0001539)10.8807186

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.08718356
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.69938141
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.61508401
4GBX2_23144817_ChIP-Seq_PC3_Human3.60801293
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.99342904
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.78950768
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.70651049
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.46328627
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.45531062
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.44855099
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43724143
12FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.36336693
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.15818755
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.08366220
15SUZ12_27294783_Chip-Seq_NPCs_Mouse2.05035341
16NFE2_27457419_Chip-Seq_LIVER_Mouse1.99393809
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91187396
18TAF15_26573619_Chip-Seq_HEK293_Human1.90483840
19PCGF2_27294783_Chip-Seq_NPCs_Mouse1.89301259
20BMI1_23680149_ChIP-Seq_NPCS_Mouse1.84013787
21FOXM1_26456572_ChIP-Seq_MCF-7_Human1.83763086
22TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.79812217
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78187534
24RNF2_27304074_Chip-Seq_NSC_Mouse1.76572463
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74513313
26EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.73969319
27FUS_26573619_Chip-Seq_HEK293_Human1.73622811
28NANOG_18555785_Chip-Seq_ESCs_Mouse1.73160174
29* REST_21632747_ChIP-Seq_MESCs_Mouse1.69504631
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66751066
31* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.65822998
32P53_22387025_ChIP-Seq_ESCs_Mouse1.65651687
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65410376
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64690631
35E2F1_18555785_Chip-Seq_ESCs_Mouse1.62661483
36VDR_22108803_ChIP-Seq_LS180_Human1.62372426
37STAT3_18555785_Chip-Seq_ESCs_Mouse1.62361816
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.60918190
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60829719
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.59703519
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.59518235
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59423230
43EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.59122224
44GATA1_26923725_Chip-Seq_HPCs_Mouse1.58558243
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.58537273
46SUZ12_18555785_Chip-Seq_ESCs_Mouse1.57459882
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.57118741
48BCAT_22108803_ChIP-Seq_LS180_Human1.57086338
49P300_18555785_Chip-Seq_ESCs_Mouse1.55350062
50CMYC_18555785_Chip-Seq_ESCs_Mouse1.52357458
51FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.51341544
52SMAD4_21799915_ChIP-Seq_A2780_Human1.50250529
53P300_19829295_ChIP-Seq_ESCs_Human1.49126652
54TCF4_22108803_ChIP-Seq_LS180_Human1.48451535
55OCT4_18555785_Chip-Seq_ESCs_Mouse1.47598994
56NMYC_18555785_Chip-Seq_ESCs_Mouse1.46421510
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46219132
58TAL1_26923725_Chip-Seq_HPCs_Mouse1.46095226
59EZH2_27304074_Chip-Seq_ESCs_Mouse1.45482507
60RUNX1_27457419_Chip-Seq_LIVER_Mouse1.44309643
61SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.43184424
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43096655
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43096655
64ETV1_20927104_ChIP-Seq_GIST48_Human1.43043166
65SOX2_18555785_Chip-Seq_ESCs_Mouse1.42902358
66CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41612239
67EED_16625203_ChIP-ChIP_MESCs_Mouse1.40955884
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40658438
69PHF8_20622853_ChIP-Seq_HELA_Human1.39293172
70NANOG_16153702_ChIP-ChIP_HESCs_Human1.39167862
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.38885694
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.38885694
73KLF4_18555785_Chip-Seq_ESCs_Mouse1.38027473
74ZFX_18555785_Chip-Seq_ESCs_Mouse1.36532985
75ESRRB_18555785_Chip-Seq_ESCs_Mouse1.35811095
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35242940
77PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.34764943
78PU1_27457419_Chip-Seq_LIVER_Mouse1.34714087
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.33968306
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33218302
81* CBP_20019798_ChIP-Seq_JUKART_Human1.32991285
82* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32991285
83DROSHA_22980978_ChIP-Seq_HELA_Human1.32870446
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32306998
85JARID2_20064375_ChIP-Seq_MESCs_Mouse1.31886344
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30831932
87IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30181080
88HNFA_21074721_ChIP-Seq_CACO-2_Human1.30041040
89STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.29739357
90AR_20517297_ChIP-Seq_VCAP_Human1.29393871
91AHR_22903824_ChIP-Seq_MCF-7_Human1.29296878
92CTCF_18555785_Chip-Seq_ESCs_Mouse1.28415130
93KDM2B_26808549_Chip-Seq_REH_Human1.28173227
94CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28052409
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.27662954
96EZH2_27294783_Chip-Seq_ESCs_Mouse1.27058498
97RBPJ_21746931_ChIP-Seq_IB4_Human1.26536802
98ER_23166858_ChIP-Seq_MCF-7_Human1.26232612
99CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.25534361
100SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.25159058
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25126407
102SMAD4_21741376_ChIP-Seq_EPCs_Human1.24675134
103SMAD1_18555785_Chip-Seq_ESCs_Mouse1.24530446
104TCF4_23295773_ChIP-Seq_U87_Human1.24347681
105SOX2_16153702_ChIP-ChIP_HESCs_Human1.23825409
106FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23607589
107SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.22963232
108WDR5_24793694_ChIP-Seq_LNCAP_Human1.21795285
109CRX_20693478_ChIP-Seq_RETINA_Mouse1.21040940
110IRF1_19129219_ChIP-ChIP_H3396_Human1.20946799
111TBL1_22424771_ChIP-Seq_293T_Human1.20781797
112EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20384012
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20184072
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18782892
115PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17693578
116CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17668121
117OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16671792
118NFYA_21822215_ChIP-Seq_K562_Human1.16457834
119SOX2_19829295_ChIP-Seq_ESCs_Human1.16081947
120NANOG_19829295_ChIP-Seq_ESCs_Human1.16081947
121* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.15895331
122SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15734473
123SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.15483524
124FOXA1_25552417_ChIP-Seq_VCAP_Human1.15376184
125RNF2_27304074_Chip-Seq_ESCs_Mouse1.14941737
126KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14763610
127STAT1_17558387_ChIP-Seq_HELA_Human1.13852775
128SMAD3_21741376_ChIP-Seq_ESCs_Human1.13249426
129AR_25329375_ChIP-Seq_VCAP_Human1.12275384
130JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11541996
131CBX2_22325352_ChIP-Seq_293T-Rex_Human1.11440299
132* STAT3_23295773_ChIP-Seq_U87_Human1.11071560
133EWS_26573619_Chip-Seq_HEK293_Human1.09764509
134NFYB_21822215_ChIP-Seq_K562_Human1.09440773
135KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09190757
136TP63_23658742_ChIP-Seq_EP156T_Human1.08884808
137TP53_18474530_ChIP-ChIP_U2OS_Human1.08822657
138RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07897754
139IGF1R_20145208_ChIP-Seq_DFB_Human1.07644478
140* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07484430
141LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07335065
142TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06837877
143FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.06554002
144AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06468083
145TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04652491
146FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04269980
147CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03884205
148SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03203466
149ZNF274_21170338_ChIP-Seq_K562_Hela1.01361368
150TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00996151
151RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00976649
152HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00865610
153RUNX2_22187159_ChIP-Seq_PCA_Human1.00633061
154TDRD3_21172665_ChIP-Seq_MCF-7_Human1.00388024
155NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99093714
156GABP_17652178_ChIP-ChIP_JURKAT_Human0.98046262
157KAP1_22055183_ChIP-Seq_ESCs_Mouse0.97382626
158GATA4_25053715_ChIP-Seq_YYC3_Human0.97154092
159PIAS1_25552417_ChIP-Seq_VCAP_Human0.97131807

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.71224212
2MP0008877_abnormal_DNA_methylation3.52704954
3MP0001188_hyperpigmentation3.42737603
4MP0006292_abnormal_olfactory_placode3.38715345
5MP0004133_heterotaxia3.09744302
6MP0008875_abnormal_xenobiotic_pharmacok3.05030824
7MP0010030_abnormal_orbit_morphology2.91814158
8MP0001293_anophthalmia2.83961076
9* MP0003698_abnormal_male_reproductive2.82975300
10MP0005646_abnormal_pituitary_gland2.74848184
11MP0003880_abnormal_central_pattern2.74417409
12MP0003787_abnormal_imprinting2.73532026
13MP0000566_synostosis2.56445798
14* MP0001929_abnormal_gametogenesis2.46416263
15MP0000383_abnormal_hair_follicle2.24607503
16MP0005645_abnormal_hypothalamus_physiol2.17961295
17MP0005248_abnormal_Harderian_gland2.16801872
18MP0004859_abnormal_synaptic_plasticity2.09788603
19MP0001984_abnormal_olfaction2.07498929
20MP0005171_absent_coat_pigmentation2.06679003
21MP0003890_abnormal_embryonic-extraembry1.99090841
22MP0009745_abnormal_behavioral_response1.96388846
23MP0002233_abnormal_nose_morphology1.96317581
24MP0009379_abnormal_foot_pigmentation1.95958377
25MP0004043_abnormal_pH_regulation1.92856034
26MP0010678_abnormal_skin_adnexa1.91666992
27MP0003937_abnormal_limbs/digits/tail_de1.91554519
28MP0001986_abnormal_taste_sensitivity1.88795717
29MP0002210_abnormal_sex_determination1.86895572
30MP0002876_abnormal_thyroid_physiology1.84055028
31MP0002735_abnormal_chemical_nociception1.82309866
32MP0001486_abnormal_startle_reflex1.79750356
33MP0000015_abnormal_ear_pigmentation1.79067834
34MP0001968_abnormal_touch/_nociception1.77111985
35MP0002282_abnormal_trachea_morphology1.76463861
36MP0008995_early_reproductive_senescence1.74797745
37MP0006276_abnormal_autonomic_nervous1.71336772
38MP0002736_abnormal_nociception_after1.68895941
39MP0009046_muscle_twitch1.67228058
40MP0005409_darkened_coat_color1.63623913
41MP0002572_abnormal_emotion/affect_behav1.61380470
42MP0001502_abnormal_circadian_rhythm1.59354366
43MP0003718_maternal_effect1.58667684
44MP0002638_abnormal_pupillary_reflex1.58534504
45MP0003635_abnormal_synaptic_transmissio1.55770099
46MP0005174_abnormal_tail_pigmentation1.54047036
47MP0004019_abnormal_vitamin_homeostasis1.54019860
48MP0002822_catalepsy1.52313326
49MP0005423_abnormal_somatic_nervous1.50635841
50MP0009697_abnormal_copulation1.44423702
51* MP0002161_abnormal_fertility/fecundity1.39554529
52MP0008058_abnormal_DNA_repair1.39512831
53MP0005670_abnormal_white_adipose1.37905122
54MP0001145_abnormal_male_reproductive1.35688052
55MP0002102_abnormal_ear_morphology1.34708339
56MP0003938_abnormal_ear_development1.33736114
57MP0002557_abnormal_social/conspecific_i1.33034566
58MP0002277_abnormal_respiratory_mucosa1.30523278
59MP0002272_abnormal_nervous_system1.30294351
60MP0002938_white_spotting1.28258319
61MP0002063_abnormal_learning/memory/cond1.28034511
62MP0003879_abnormal_hair_cell1.27667695
63MP0002064_seizures1.27298076
64MP0000653_abnormal_sex_gland1.26094776
65MP0001905_abnormal_dopamine_level1.25388270
66MP0006072_abnormal_retinal_apoptosis1.24252388
67MP0002132_abnormal_respiratory_system1.22374197
68MP0001286_abnormal_eye_development1.21870786
69MP0000026_abnormal_inner_ear1.21269874
70MP0003119_abnormal_digestive_system1.19725221
71MP0001529_abnormal_vocalization1.19630803
72MP0005083_abnormal_biliary_tract1.19504913
73MP0002160_abnormal_reproductive_system1.18246546
74MP0002697_abnormal_eye_size1.16301494
75MP0002653_abnormal_ependyma_morphology1.15725207
76MP0002067_abnormal_sensory_capabilities1.14801603
77MP0005395_other_phenotype1.13726469
78MP0001963_abnormal_hearing_physiology1.13150522
79MP0005075_abnormal_melanosome_morpholog1.13138512
80MP0003878_abnormal_ear_physiology1.12335601
81MP0005377_hearing/vestibular/ear_phenot1.12335601
82MP0005499_abnormal_olfactory_system1.11545002
83MP0005394_taste/olfaction_phenotype1.11545002
84MP0003693_abnormal_embryo_hatching1.10283988
85MP0001501_abnormal_sleep_pattern1.09664509
86MP0005379_endocrine/exocrine_gland_phen1.09530782
87MP0004742_abnormal_vestibular_system1.09081094
88MP0001299_abnormal_eye_distance/1.08789146
89MP0005391_vision/eye_phenotype1.07270752
90MP0005623_abnormal_meninges_morphology1.06352282
91MP0004142_abnormal_muscle_tone1.05896483
92MP0003122_maternal_imprinting1.05150071
93MP0005408_hypopigmentation1.04055592
94MP0003136_yellow_coat_color1.02955135
95MP0001346_abnormal_lacrimal_gland1.02420960
96MP0002092_abnormal_eye_morphology1.02264773
97MP0002084_abnormal_developmental_patter1.02186386
98MP0002249_abnormal_larynx_morphology1.00657078
99MP0002928_abnormal_bile_duct1.00425290
100MP0003121_genomic_imprinting1.00195546
101MP0001324_abnormal_eye_pigmentation1.00015814
102MP0002163_abnormal_gland_morphology0.98936383
103MP0005367_renal/urinary_system_phenotyp0.96665283
104MP0000516_abnormal_urinary_system0.96665283
105MP0001440_abnormal_grooming_behavior0.96385785
106MP0004264_abnormal_extraembryonic_tissu0.95694896
107MP0002111_abnormal_tail_morphology0.95480513
108MP0002254_reproductive_system_inflammat0.95420023
109MP0003861_abnormal_nervous_system0.95034881
110MP0000049_abnormal_middle_ear0.94304694
111MP0009703_decreased_birth_body0.93459593
112MP0010386_abnormal_urinary_bladder0.92887152
113MP0002085_abnormal_embryonic_tissue0.91395794
114MP0000428_abnormal_craniofacial_morphol0.90963083
115MP0005551_abnormal_eye_electrophysiolog0.90829655
116MP0003786_premature_aging0.89345021
117MP0000778_abnormal_nervous_system0.88705649
118MP0008789_abnormal_olfactory_epithelium0.88703536
119MP0000678_abnormal_parathyroid_gland0.88664209
120MP0002168_other_aberrant_phenotype0.86846353
121MP0002734_abnormal_mechanical_nocicepti0.86262255
122MP0005195_abnormal_posterior_eye0.86036432
123MP0009053_abnormal_anal_canal0.84833997
124MP0002095_abnormal_skin_pigmentation0.84264559
125MP0003941_abnormal_skin_development0.81589992
126MP0008260_abnormal_autophagy0.81212667
127MP0000631_abnormal_neuroendocrine_gland0.79746158
128MP0010234_abnormal_vibrissa_follicle0.77349304
129MP0000427_abnormal_hair_cycle0.76469234
130MP0004381_abnormal_hair_follicle0.76137291
131MP0000681_abnormal_thyroid_gland0.75669453
132MP0002116_abnormal_craniofacial_bone0.75364583
133MP0004270_analgesia0.75125614
134MP0000579_abnormal_nail_morphology0.74925697
135MP0003755_abnormal_palate_morphology0.74818904
136MP0005253_abnormal_eye_physiology0.73932204
137MP0000372_irregular_coat_pigmentation0.73556448
138MP0001485_abnormal_pinna_reflex0.72909305
139MP0002148_abnormal_hypersensitivity_rea0.72799690
140MP0002752_abnormal_somatic_nervous0.72778380
141MP0002909_abnormal_adrenal_gland0.72166353
142MP0000432_abnormal_head_morphology0.72124461
143MP0002234_abnormal_pharynx_morphology0.71858834
144MP0001765_abnormal_ion_homeostasis0.71429730
145MP0005389_reproductive_system_phenotype0.70456434
146MP0003942_abnormal_urinary_system0.69816179
147MP0000647_abnormal_sebaceous_gland0.69367977
148MP0002184_abnormal_innervation0.68786171
149MP0001119_abnormal_female_reproductive0.66020769
150MP0004957_abnormal_blastocyst_morpholog0.65544338
151MP0002882_abnormal_neuron_morphology0.64842345
152MP0009780_abnormal_chondrocyte_physiolo0.64652458
153MP0001664_abnormal_digestion0.64420645
154MP0003111_abnormal_nucleus_morphology0.63903414
155MP0001970_abnormal_pain_threshold0.63399373
156MP0004924_abnormal_behavior0.60938115
157MP0005386_behavior/neurological_phenoty0.60938115

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)8.62936950
2Absent/shortened dynein arms (HP:0200106)8.62936950
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.02448214
4Abnormal respiratory motile cilium morphology (HP:0005938)6.43888705
5Abnormal respiratory epithelium morphology (HP:0012253)6.43888705
6Abnormal respiratory motile cilium physiology (HP:0012261)6.03212430
7Abnormal ciliary motility (HP:0012262)5.71415442
8Rhinitis (HP:0012384)4.49051394
9Nephronophthisis (HP:0000090)4.30535094
10Tubulointerstitial nephritis (HP:0001970)3.94780067
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.76307280
12Abnormality of the nasal mucosa (HP:0000433)3.75443680
13Occipital encephalocele (HP:0002085)3.51749868
14Abnormality of the renal medulla (HP:0100957)3.45909577
15Chronic sinusitis (HP:0011109)3.43010744
16Molar tooth sign on MRI (HP:0002419)3.41397644
17Abnormality of midbrain morphology (HP:0002418)3.41397644
18Chromsome breakage (HP:0040012)3.20275951
19Chronic bronchitis (HP:0004469)3.16683758
20Medial flaring of the eyebrow (HP:0010747)3.15501731
21Infertility (HP:0000789)3.08713803
22Focal motor seizures (HP:0011153)3.02884464
23True hermaphroditism (HP:0010459)2.98530584
24Pancreatic fibrosis (HP:0100732)2.85870461
25Anencephaly (HP:0002323)2.83168070
26Chronic hepatic failure (HP:0100626)2.76003224
27Male infertility (HP:0003251)2.72837454
28Bronchiectasis (HP:0002110)2.70220478
29Febrile seizures (HP:0002373)2.66404279
30Postaxial foot polydactyly (HP:0001830)2.57033108
31Chronic otitis media (HP:0000389)2.53281452
32Nephrogenic diabetes insipidus (HP:0009806)2.49977191
33Abnormality of the renal cortex (HP:0011035)2.45885418
34Sclerocornea (HP:0000647)2.43021901
35Congenital primary aphakia (HP:0007707)2.41894407
36Median cleft lip (HP:0000161)2.38982966
37Gait imbalance (HP:0002141)2.38982819
38Congenital hepatic fibrosis (HP:0002612)2.37923054
39Hyperactive renin-angiotensin system (HP:0000841)2.35018907
40Abnormal hair whorl (HP:0010721)2.33629907
41Abnormality of the renal collecting system (HP:0004742)2.32923999
42Optic neuritis (HP:0100653)2.32360081
43Retrobulbar optic neuritis (HP:0100654)2.32360081
44Cystic liver disease (HP:0006706)2.28147955
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.26125405
46Abnormality of the preputium (HP:0100587)2.24210343
47Pancreatic cysts (HP:0001737)2.23479684
48Duplicated collecting system (HP:0000081)2.22346637
49Renal cortical cysts (HP:0000803)2.20389602
50Recurrent sinusitis (HP:0011108)2.17328040
51Clubbing of toes (HP:0100760)2.16670868
52Meckel diverticulum (HP:0002245)2.15036640
53Abnormality of the ileum (HP:0001549)2.07012181
54Abnormal spermatogenesis (HP:0008669)2.06320280
55Poor coordination (HP:0002370)2.04012679
56Abnormality of molar (HP:0011077)2.02987540
57Abnormality of molar morphology (HP:0011070)2.02987540
58Stage 5 chronic kidney disease (HP:0003774)2.02115183
59Abnormality of DNA repair (HP:0003254)2.02112109
60Hyperkalemia (HP:0002153)2.02100607
61Tubulointerstitial abnormality (HP:0001969)1.99936191
62Preaxial hand polydactyly (HP:0001177)1.99173947
63Atelectasis (HP:0100750)1.98704327
64Abnormality of permanent molar morphology (HP:0011071)1.96690407
65Abnormality of the dental root (HP:0006486)1.96690407
66Taurodontia (HP:0000679)1.96690407
67Astigmatism (HP:0000483)1.96375520
68Fibular hypoplasia (HP:0003038)1.95990443
69Ectopic kidney (HP:0000086)1.95224627
70Tubular atrophy (HP:0000092)1.94164115
71Impulsivity (HP:0100710)1.93198944
72Decreased central vision (HP:0007663)1.92346061
73Aplasia/Hypoplasia of the spleen (HP:0010451)1.92037984
74Aplasia/Hypoplasia of the lens (HP:0008063)1.92005872
75Asplenia (HP:0001746)1.88032865
76Decreased circulating renin level (HP:0003351)1.87642547
77Bell-shaped thorax (HP:0001591)1.87606469
78Nephropathy (HP:0000112)1.85921004
79White forelock (HP:0002211)1.85546558
80Nephroblastoma (Wilms tumor) (HP:0002667)1.85368165
81Nasal polyposis (HP:0100582)1.83849733
82Aganglionic megacolon (HP:0002251)1.83131342
83Postaxial hand polydactyly (HP:0001162)1.81029253
84Bronchitis (HP:0012387)1.79433810
85Abnormality of chromosome stability (HP:0003220)1.79288840
86Optic nerve hypoplasia (HP:0000609)1.79264138
87Supernumerary spleens (HP:0009799)1.78942365
88Abnormality of the dental pulp (HP:0006479)1.77966890
89Septo-optic dysplasia (HP:0100842)1.77724337
90Azoospermia (HP:0000027)1.76973336
91Hyperphosphatemia (HP:0002905)1.75409380
92Stomach cancer (HP:0012126)1.74078623
93Patchy hypopigmentation of hair (HP:0011365)1.73142480
94Renal dysplasia (HP:0000110)1.72776955
95Epileptic encephalopathy (HP:0200134)1.72400619
96Embryonal renal neoplasm (HP:0011794)1.71757282
97Furrowed tongue (HP:0000221)1.70553706
98Abnormality of the carotid arteries (HP:0005344)1.69259848
99Genital tract atresia (HP:0001827)1.69216333
100Anophthalmia (HP:0000528)1.68416204
101Aplasia/Hypoplasia of the tongue (HP:0010295)1.66744426
102Colon cancer (HP:0003003)1.66403903
103Vaginal atresia (HP:0000148)1.66137306
104Broad foot (HP:0001769)1.65508552
105Male pseudohermaphroditism (HP:0000037)1.64641592
106Progressive cerebellar ataxia (HP:0002073)1.64625691
107Bile duct proliferation (HP:0001408)1.63597409
108Abnormal biliary tract physiology (HP:0012439)1.63597409
109Fair hair (HP:0002286)1.63370471
110Oculomotor apraxia (HP:0000657)1.61437532
111Maternal diabetes (HP:0009800)1.61136048
112Oligohydramnios (HP:0001562)1.60929289
113Recurrent otitis media (HP:0000403)1.60358238
114Renal salt wasting (HP:0000127)1.59971000
115Holoprosencephaly (HP:0001360)1.59889827
116Type I transferrin isoform profile (HP:0003642)1.58115894
117Keratoconjunctivitis sicca (HP:0001097)1.57596658
118Abnormality of renal resorption (HP:0011038)1.57501341
119Absent rod-and cone-mediated responses on ERG (HP:0007688)1.56649491
120Facial cleft (HP:0002006)1.55686195
121Abnormality of abdominal situs (HP:0011620)1.55553722
122Abdominal situs inversus (HP:0003363)1.55553722
123Orchitis (HP:0100796)1.55470610
124Bifid tongue (HP:0010297)1.53506129
125Multicystic kidney dysplasia (HP:0000003)1.52077924
126Absent frontal sinuses (HP:0002688)1.51911840
127Abnormality of the labia minora (HP:0012880)1.39300412
128Narrow forehead (HP:0000341)1.38656850
129Aplasia/Hypoplasia of the sacrum (HP:0008517)1.38463147
130Optic nerve coloboma (HP:0000588)1.36481178
131Specific learning disability (HP:0001328)1.33892754
132Hip dysplasia (HP:0001385)1.30853915
133Retinitis pigmentosa (HP:0000510)1.30839656
134Prominent nasal bridge (HP:0000426)1.30328545
135Cone-rod dystrophy (HP:0000548)1.27576092
136Decreased testicular size (HP:0008734)1.27212204
137Abnormal rod and cone electroretinograms (HP:0008323)1.26610271
138Chorioretinal coloboma (HP:0000567)1.26231611
139Bifid scrotum (HP:0000048)1.24022109
140Abnormality of chloride homeostasis (HP:0011422)1.23553956
141Hyperaldosteronism (HP:0000859)1.23110475
142Dandy-Walker malformation (HP:0001305)1.22463181
143Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.22306082
144Abnormality of the middle phalanges of the toes (HP:0010183)1.20578102
145Hyperglycinemia (HP:0002154)1.20286588
146Labial hypoplasia (HP:0000066)1.19355424
147Polydipsia (HP:0001959)1.19193300
148Abnormal drinking behavior (HP:0030082)1.19193300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.18279500
2MST44.01861485
3NTRK33.97134849
4ZAK3.80742432
5PDK32.86430442
6PDK42.86430442
7STK162.63457161
8EPHA22.61019988
9FRK2.59566432
10CASK2.47651226
11IRAK32.29835154
12PRPF4B2.21355417
13STK242.16615330
14IRAK42.11935474
15PDK22.10783340
16CDK191.94332891
17BMPR1B1.93547742
18TXK1.87460041
19BRD41.83227081
20MAP2K71.82488252
21NME11.79295703
22BCR1.73125543
23PBK1.70746103
24TRIM281.70613364
25MAP4K21.69801348
26FGFR21.64877640
27SRPK11.59101153
28EPHA41.57869832
29PRKD31.55815093
30NEK61.54723562
31BRSK21.50436431
32YES11.49963797
33AKT31.47919534
34CDC71.45543065
35MKNK21.43724403
36SIK31.43632043
37ADRBK21.39419848
38DYRK31.38950509
39MAPK131.38587576
40EIF2AK21.36841780
41BMPR21.33371560
42TNK21.33291451
43PLK11.33244728
44PASK1.32822313
45ACVR1B1.31893735
46IRAK11.31260136
47MUSK1.30106964
48DYRK21.27274303
49SGK21.27126846
50STK381.23588602
51MAP3K141.21384303
52CDK31.20946615
53MAP3K21.15946111
54PINK11.13307078
55TAOK21.10025462
56OXSR11.09498991
57STK31.09025460
58MAP3K121.06618713
59WEE11.06475806
60TLK11.04322753
61NEK21.04071382
62BUB11.03695795
63TTK1.00113097
64GRK10.97340857
65PTK2B0.96950966
66IRAK20.96306602
67PNCK0.95517214
68MAP2K60.92977651
69TESK10.92968921
70GRK70.89245466
71MKNK10.87044557
72ERBB30.86173101
73TSSK60.85903764
74PLK40.85424128
75PRKCI0.85213125
76VRK20.84834599
77MARK20.84833360
78STK38L0.81902687
79NEK10.81528286
80TIE10.80767836
81ATR0.78712406
82TEC0.76967039
83CSNK1G10.75766193
84AURKA0.75075118
85CCNB10.74962644
86INSRR0.74630324
87PRKCG0.74372121
88CHEK20.74314090
89LATS10.71533625
90TAF10.71015654
91SGK2230.70268244
92SGK4940.70268244
93PLK30.69840227
94NTRK20.67951473
95CAMK1G0.66891767
96WNK40.66389102
97VRK10.66169785
98ICK0.64275378
99PRKD20.63289409
100MARK10.63052675
101SGK30.63028337
102RIPK40.62778808
103RPS6KB20.60971419
104ERBB20.60944454
105SGK10.60125942
106CAMK2A0.59044130
107MAPK150.59039195
108FES0.57957018
109MAP3K70.57551408
110PRKCH0.56077881
111AURKB0.55777006
112PRKCE0.54567053
113CAMK10.53950410
114MAPKAPK30.53399494
115PIK3CA0.52621267
116CSNK1G20.51847323
117STK110.51782025
118WNK30.51574229
119CDK80.50526034
120NUAK10.49210766
121STK100.48307441
122TAOK10.48290061
123MET0.47804288
124MAP3K40.45931055
125IKBKE0.45055553
126STK390.44837661
127EIF2AK10.41607466
128PIK3CG0.41498285
129PLK20.40422609
130FER0.40212261
131KIT0.39389901
132CAMK2B0.38519478
133CSNK1G30.37271713
134CSK0.36167421
135WNK10.35229392
136PRKG10.35018455
137CSNK1A1L0.33970655
138MAP2K40.33639377
139MAP3K60.33029384
140LYN0.32466548
141LRRK20.31694272
142RPS6KB10.31691206
143ATM0.31514159
144LMTK20.31155808
145PRKACA0.31110652
146PRKCD0.30826810
147DYRK1B0.30731553
148PRKCZ0.30372939
149MAPK70.30008594
150NLK0.29617916
151DYRK1A0.29202841
152FGFR10.29078777
153JAK30.28677119
154BRAF0.28607462
155CDK90.28050121
156CHEK10.27979271
157EIF2AK30.27890182
158FLT30.27813066
159GSK3B0.27365937

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.75776190
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.48871658
3Fanconi anemia pathway_Homo sapiens_hsa034603.20108969
4Chemical carcinogenesis_Homo sapiens_hsa052042.87136300
5Histidine metabolism_Homo sapiens_hsa003402.83372182
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.75291885
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.73572423
8beta-Alanine metabolism_Homo sapiens_hsa004102.58721736
9Phenylalanine metabolism_Homo sapiens_hsa003602.53853777
10Taste transduction_Homo sapiens_hsa047422.40971962
11Vitamin B6 metabolism_Homo sapiens_hsa007502.38164989
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.30601184
13Caffeine metabolism_Homo sapiens_hsa002322.27858699
14Glutathione metabolism_Homo sapiens_hsa004802.17650873
15Olfactory transduction_Homo sapiens_hsa047402.06291972
16Tyrosine metabolism_Homo sapiens_hsa003502.05887694
17Morphine addiction_Homo sapiens_hsa050322.05447985
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.05043771
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.03737311
20Mismatch repair_Homo sapiens_hsa034302.02900451
21Glutamatergic synapse_Homo sapiens_hsa047242.01255484
22Basal transcription factors_Homo sapiens_hsa030222.00638455
23Amphetamine addiction_Homo sapiens_hsa050311.98234598
24Circadian entrainment_Homo sapiens_hsa047131.97235637
25Propanoate metabolism_Homo sapiens_hsa006401.90616784
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.81737626
27Retinol metabolism_Homo sapiens_hsa008301.71529542
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68015433
29Hedgehog signaling pathway_Homo sapiens_hsa043401.66300438
30Calcium signaling pathway_Homo sapiens_hsa040201.63963207
31Homologous recombination_Homo sapiens_hsa034401.61035652
32Autoimmune thyroid disease_Homo sapiens_hsa053201.54306922
33Graft-versus-host disease_Homo sapiens_hsa053321.53659098
34Tight junction_Homo sapiens_hsa045301.49906368
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.46196317
36Peroxisome_Homo sapiens_hsa041461.45205708
37Insulin secretion_Homo sapiens_hsa049111.39095062
38Serotonergic synapse_Homo sapiens_hsa047261.36568093
39Long-term potentiation_Homo sapiens_hsa047201.32823542
40Cocaine addiction_Homo sapiens_hsa050301.32770981
41Steroid biosynthesis_Homo sapiens_hsa001001.31970435
42Purine metabolism_Homo sapiens_hsa002301.31343964
43Arachidonic acid metabolism_Homo sapiens_hsa005901.31035080
44Phototransduction_Homo sapiens_hsa047441.30091083
45Fatty acid degradation_Homo sapiens_hsa000711.28232005
46Collecting duct acid secretion_Homo sapiens_hsa049661.27741563
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27016259
48Sphingolipid metabolism_Homo sapiens_hsa006001.24849113
49GABAergic synapse_Homo sapiens_hsa047271.24816939
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23684467
51Hippo signaling pathway_Homo sapiens_hsa043901.21635315
52Protein export_Homo sapiens_hsa030601.21108658
53Huntingtons disease_Homo sapiens_hsa050161.16949776
54Synaptic vesicle cycle_Homo sapiens_hsa047211.15882695
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15626943
56Ribosome_Homo sapiens_hsa030101.12848479
57Butanoate metabolism_Homo sapiens_hsa006501.12187122
58Selenocompound metabolism_Homo sapiens_hsa004501.11061048
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10360280
60SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07884490
61Ether lipid metabolism_Homo sapiens_hsa005651.06380316
62Steroid hormone biosynthesis_Homo sapiens_hsa001401.06171380
63Linoleic acid metabolism_Homo sapiens_hsa005911.05686950
64Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04510960
65Adherens junction_Homo sapiens_hsa045201.04020364
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02984155
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02772181
68Folate biosynthesis_Homo sapiens_hsa007901.02008847
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01104184
70Allograft rejection_Homo sapiens_hsa053300.99860858
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98634489
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.97146909
73Circadian rhythm_Homo sapiens_hsa047100.96519187
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.96471788
75Rheumatoid arthritis_Homo sapiens_hsa053230.92672051
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92381815
77Starch and sucrose metabolism_Homo sapiens_hsa005000.92198869
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91649200
79Salivary secretion_Homo sapiens_hsa049700.90956094
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89887435
81p53 signaling pathway_Homo sapiens_hsa041150.89536755
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.89371634
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.89325777
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88163473
85Renin secretion_Homo sapiens_hsa049240.88054805
86Type I diabetes mellitus_Homo sapiens_hsa049400.87809563
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87460745
88Pyrimidine metabolism_Homo sapiens_hsa002400.86038405
89RNA transport_Homo sapiens_hsa030130.85192232
90Dopaminergic synapse_Homo sapiens_hsa047280.84748952
91cAMP signaling pathway_Homo sapiens_hsa040240.82462877
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.80735761
93Non-homologous end-joining_Homo sapiens_hsa034500.79606480
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78675420
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.77218939
96Inositol phosphate metabolism_Homo sapiens_hsa005620.76966598
97Other glycan degradation_Homo sapiens_hsa005110.76953952
98Pyruvate metabolism_Homo sapiens_hsa006200.75749867
99Measles_Homo sapiens_hsa051620.75625728
100Regulation of autophagy_Homo sapiens_hsa041400.75366177
101Fatty acid biosynthesis_Homo sapiens_hsa000610.73855047
102Base excision repair_Homo sapiens_hsa034100.73217262
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72502409
104Metabolic pathways_Homo sapiens_hsa011000.72284634
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.70379662
106Spliceosome_Homo sapiens_hsa030400.70131661
107Nitrogen metabolism_Homo sapiens_hsa009100.69819112
108Fatty acid elongation_Homo sapiens_hsa000620.69241382
109Cholinergic synapse_Homo sapiens_hsa047250.69240596
110Tryptophan metabolism_Homo sapiens_hsa003800.68701067
111mRNA surveillance pathway_Homo sapiens_hsa030150.68369865
112ABC transporters_Homo sapiens_hsa020100.67447653
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63355101
114Ovarian steroidogenesis_Homo sapiens_hsa049130.62821663
115DNA replication_Homo sapiens_hsa030300.62407270
116NF-kappa B signaling pathway_Homo sapiens_hsa040640.61340305
117Oxytocin signaling pathway_Homo sapiens_hsa049210.61036135
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60781196
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60724351
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60672550
121Hematopoietic cell lineage_Homo sapiens_hsa046400.60388758
122Axon guidance_Homo sapiens_hsa043600.60310753
123Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60156849
124Cell cycle_Homo sapiens_hsa041100.58562195
125Dorso-ventral axis formation_Homo sapiens_hsa043200.57477750
126RNA degradation_Homo sapiens_hsa030180.57299954
127Glucagon signaling pathway_Homo sapiens_hsa049220.56555710
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55713141
129Notch signaling pathway_Homo sapiens_hsa043300.55665227
130Parkinsons disease_Homo sapiens_hsa050120.54387561
131Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53701074
132Long-term depression_Homo sapiens_hsa047300.53114017
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52893150
134Mineral absorption_Homo sapiens_hsa049780.52875656
135Primary immunodeficiency_Homo sapiens_hsa053400.52568586
136Arginine and proline metabolism_Homo sapiens_hsa003300.52343819
137Vitamin digestion and absorption_Homo sapiens_hsa049770.51878955
138Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51544918
139Nucleotide excision repair_Homo sapiens_hsa034200.50691705
140African trypanosomiasis_Homo sapiens_hsa051430.50518711
141N-Glycan biosynthesis_Homo sapiens_hsa005100.50223549
142RNA polymerase_Homo sapiens_hsa030200.50049388
143Wnt signaling pathway_Homo sapiens_hsa043100.49149503
144Proteasome_Homo sapiens_hsa030500.49097813
145Oxidative phosphorylation_Homo sapiens_hsa001900.47240869
146Drug metabolism - other enzymes_Homo sapiens_hsa009830.46906237
147Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41580028
148TGF-beta signaling pathway_Homo sapiens_hsa043500.41537409
149Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40695518
150Cardiac muscle contraction_Homo sapiens_hsa042600.39876031
151Oocyte meiosis_Homo sapiens_hsa041140.39702442
152Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39198708
153Influenza A_Homo sapiens_hsa051640.38678380
154Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38444570
155Gastric acid secretion_Homo sapiens_hsa049710.38387026
156Vascular smooth muscle contraction_Homo sapiens_hsa042700.37608660
157Basal cell carcinoma_Homo sapiens_hsa052170.37304475
158NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36643035
159Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36036191
160Herpes simplex infection_Homo sapiens_hsa051680.35060165
161Glycerolipid metabolism_Homo sapiens_hsa005610.30471024

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