NT5C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nucleotidase that catalyzes the dephosphorylation of the 5' deoxyribonucleotides (dNTP) and 2'(3')-dNTP and ribonucleotides, but not 5' ribonucleotides. Of the different forms of nucleotidases characterized, this enzyme is unique in its preference for 5'-dNTP. It may be one of the enzymes involved in regulating the size of dNTP pools in cells. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.43746219
2ribosomal small subunit assembly (GO:0000028)6.41426625
3translational termination (GO:0006415)6.21395834
4ribosomal small subunit biogenesis (GO:0042274)5.81668933
5DNA deamination (GO:0045006)5.54573186
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.49301410
7cotranslational protein targeting to membrane (GO:0006613)5.40744885
8protein targeting to ER (GO:0045047)5.38578562
9translational elongation (GO:0006414)5.38306742
10protein localization to endoplasmic reticulum (GO:0070972)5.12833225
11establishment of protein localization to endoplasmic reticulum (GO:0072599)5.09154402
12ribosomal large subunit biogenesis (GO:0042273)5.01160086
13viral life cycle (GO:0019058)4.99301981
14cellular protein complex disassembly (GO:0043624)4.91775647
15translational initiation (GO:0006413)4.73974361
16* pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.70133084
17GDP-mannose metabolic process (GO:0019673)4.68499381
18maturation of SSU-rRNA (GO:0030490)4.63862372
19nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.57640782
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.36473294
21ATP synthesis coupled proton transport (GO:0015986)4.16410253
22energy coupled proton transport, down electrochemical gradient (GO:0015985)4.16410253
23proteasome assembly (GO:0043248)4.15301371
24protein complex disassembly (GO:0043241)4.13533418
25translation (GO:0006412)4.06592037
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.99091983
27macromolecular complex disassembly (GO:0032984)3.92682834
28base-excision repair, AP site formation (GO:0006285)3.91774539
29sequestering of actin monomers (GO:0042989)3.90884470
30* deoxyribonucleotide catabolic process (GO:0009264)3.90537688
31antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.89625541
32iron-sulfur cluster assembly (GO:0016226)3.87018654
33metallo-sulfur cluster assembly (GO:0031163)3.87018654
34negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.80777338
35* deoxyribose phosphate catabolic process (GO:0046386)3.75141643
36* pyrimidine nucleotide catabolic process (GO:0006244)3.73659183
37* pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.73487383
38ribonucleoprotein complex biogenesis (GO:0022613)3.71807900
39regulation of cellular amino acid metabolic process (GO:0006521)3.66582863
40protein targeting to membrane (GO:0006612)3.63490253
41purine deoxyribonucleotide catabolic process (GO:0009155)3.55406532
42DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.55346627
43nucleotide salvage (GO:0043173)3.54368532
44intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.48450628
45signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.48450628
46peptidyl-arginine omega-N-methylation (GO:0035247)3.48338320
47negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.47944384
48negative regulation of ligase activity (GO:0051352)3.47944384
49UTP biosynthetic process (GO:0006228)3.45833763
50signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.45791230
51signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.45791230
52signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.45791230
53pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.43867850
54pseudouridine synthesis (GO:0001522)3.41601057
55positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.41044718
56purine nucleotide salvage (GO:0032261)3.36070654
57negative regulation of B cell apoptotic process (GO:0002903)3.34093547
58signal transduction involved in DNA damage checkpoint (GO:0072422)3.32953910
59signal transduction involved in DNA integrity checkpoint (GO:0072401)3.32953910
60formation of translation preinitiation complex (GO:0001731)3.32053600
61negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.31556992
62transcription elongation from RNA polymerase III promoter (GO:0006385)3.30147418
63termination of RNA polymerase III transcription (GO:0006386)3.30147418
64tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.30083719
65RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.30083719
66signal transduction involved in cell cycle checkpoint (GO:0072395)3.28573066
67regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.27357603
68nuclear-transcribed mRNA catabolic process (GO:0000956)3.26770316
69pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.24527364
70cellular component biogenesis (GO:0044085)3.23109116
71protein maturation by protein folding (GO:0022417)3.22610042
72negative regulation of DNA-templated transcription, elongation (GO:0032785)3.20454856
73mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.19526593
74UTP metabolic process (GO:0046051)3.18977908
75deoxyribose phosphate biosynthetic process (GO:0046385)3.18525123
762-deoxyribonucleotide biosynthetic process (GO:0009265)3.18525123
77UV protection (GO:0009650)3.15743232
78respiratory electron transport chain (GO:0022904)3.14778662
79anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.13386326
80pentose metabolic process (GO:0019321)3.13181604
81CTP metabolic process (GO:0046036)3.12917003
82CTP biosynthetic process (GO:0006241)3.12917003
83antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.12296252
84antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.12296252
85establishment of viral latency (GO:0019043)3.11876222
86negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.11025619
87electron transport chain (GO:0022900)3.10095938
88mRNA catabolic process (GO:0006402)3.08955940
89rRNA processing (GO:0006364)3.07605934
90pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.07336647
91antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.07264048
92regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.05715485
93deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.04097344
942-deoxyribonucleotide metabolic process (GO:0009394)3.02912599
95protein neddylation (GO:0045116)3.01083023
96Arp2/3 complex-mediated actin nucleation (GO:0034314)3.00558590
97positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.00485142
98oxidative phosphorylation (GO:0006119)2.99680704
99antigen processing and presentation of endogenous antigen (GO:0019883)2.99612459
100establishment of protein localization to mitochondrial membrane (GO:0090151)2.99534168
101histone arginine methylation (GO:0034969)2.99103495
102protein targeting to mitochondrion (GO:0006626)2.97836129
103rRNA metabolic process (GO:0016072)2.96641972
104mitochondrial calcium ion transport (GO:0006851)2.93586579
105rRNA modification (GO:0000154)2.92444835
106* deoxyribose phosphate metabolic process (GO:0019692)2.91483733
107establishment of protein localization to mitochondrion (GO:0072655)2.90943304
108pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.89574287
109ribosome biogenesis (GO:0042254)2.88372454
110RNA catabolic process (GO:0006401)2.88056177
111mitochondrial respiratory chain complex I assembly (GO:0032981)2.87748629
112NADH dehydrogenase complex assembly (GO:0010257)2.87748629
113mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.87748629
114protein complex biogenesis (GO:0070271)2.86229253
115cellular response to interferon-beta (GO:0035458)2.85852688
116deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.84636961
117positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.82350343
118NIK/NF-kappaB signaling (GO:0038061)2.81761161
119proline biosynthetic process (GO:0006561)2.81281628
120DNA strand elongation (GO:0022616)2.80918199
121positive regulation of cell cycle arrest (GO:0071158)2.78742152
122respiratory chain complex IV assembly (GO:0008535)2.77171865
123positive regulation of ligase activity (GO:0051351)2.76033261
124chaperone-mediated protein transport (GO:0072321)2.75686683
125pyrimidine nucleoside biosynthetic process (GO:0046134)2.74366680
126pentose-phosphate shunt (GO:0006098)2.74309579
127response to interferon-beta (GO:0035456)2.73838454
128telomere maintenance via semi-conservative replication (GO:0032201)2.71928631
129mitochondrial respiratory chain complex assembly (GO:0033108)2.71112811
130regulation of mitochondrial translation (GO:0070129)2.70327345
131heme biosynthetic process (GO:0006783)2.70052145
132negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.69996790
133protein localization to mitochondrion (GO:0070585)2.69195530
1347-methylguanosine mRNA capping (GO:0006370)2.67069633
135rRNA transcription (GO:0009303)2.66965267
136nucleoside salvage (GO:0043174)2.66148260
137regulation of cellular amine metabolic process (GO:0033238)2.66070324
138peptidyl-arginine methylation (GO:0018216)2.65759318
139peptidyl-arginine N-methylation (GO:0035246)2.65759318
140DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.65683280
141regulation of protein heterodimerization activity (GO:0043497)2.63883984
142cytochrome complex assembly (GO:0017004)2.62602656
143peptidyl-histidine modification (GO:0018202)2.62461570
144base-excision repair (GO:0006284)2.62385837
145GTP biosynthetic process (GO:0006183)2.60051292
146RNA capping (GO:0036260)2.59101129
1477-methylguanosine RNA capping (GO:0009452)2.59101129
148regulation of gamma-delta T cell differentiation (GO:0045586)2.59058649
149DNA strand elongation involved in DNA replication (GO:0006271)2.57582239
150establishment of protein localization to membrane (GO:0090150)2.57290943
151nucleobase-containing small molecule interconversion (GO:0015949)2.56262074
152positive regulation of gamma-delta T cell activation (GO:0046645)2.56111942
153protein targeting (GO:0006605)2.55207660
154guanosine-containing compound biosynthetic process (GO:1901070)2.53929666

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.12544647
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.04996348
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.72574297
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.62097776
5E2F7_22180533_ChIP-Seq_HELA_Human3.51386920
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.43359794
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.34177590
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.22310304
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.16073193
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.12761867
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.82970181
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.74093941
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.73247784
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.67149540
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.65276814
16SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.63980520
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.48269221
18VDR_23849224_ChIP-Seq_CD4+_Human2.46723729
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.45874547
20FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.38007548
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.34388157
22XRN2_22483619_ChIP-Seq_HELA_Human2.31357889
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.27699373
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.25499908
25IRF8_21731497_ChIP-ChIP_J774_Mouse2.25048418
26DCP1A_22483619_ChIP-Seq_HELA_Human2.22171865
27* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.18807912
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.13975194
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12471201
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.10012098
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08274190
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.01771112
33FOXP3_21729870_ChIP-Seq_TREG_Human1.95384434
34* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94239087
35CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.94207492
36STAT4_19710469_ChIP-ChIP_TH1__Mouse1.87228815
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.82584999
38TTF2_22483619_ChIP-Seq_HELA_Human1.80025047
39ELK1_19687146_ChIP-ChIP_HELA_Human1.79791112
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78106041
41* GABP_19822575_ChIP-Seq_HepG2_Human1.75745689
42LXR_22292898_ChIP-Seq_THP-1_Human1.74368357
43SPI1_23547873_ChIP-Seq_NB4_Human1.74360051
44CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.74157489
45MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.73773848
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73593943
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72370402
48* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.71647707
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.69187094
50* TET1_21451524_ChIP-Seq_MESCs_Mouse1.65373460
51ELK1_22589737_ChIP-Seq_MCF10A_Human1.65261416
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.62582699
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.62050926
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.61026123
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.60103341
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58824412
57P68_20966046_ChIP-Seq_HELA_Human1.56772646
58SRY_22984422_ChIP-ChIP_TESTIS_Rat1.54986565
59BCL6_27268052_Chip-Seq_Bcells_Human1.54908326
60VDR_21846776_ChIP-Seq_THP-1_Human1.53985489
61BP1_19119308_ChIP-ChIP_Hs578T_Human1.52022547
62ZNF263_19887448_ChIP-Seq_K562_Human1.47939079
63ELF1_20517297_ChIP-Seq_JURKAT_Human1.47542786
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.46497926
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.43765744
66FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.43694770
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.42701217
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41588041
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41442980
70FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.38282481
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.37175367
72BCOR_27268052_Chip-Seq_Bcells_Human1.36669287
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32746426
74MYB_21317192_ChIP-Seq_ERMYB_Mouse1.28536306
75FOXP1_21924763_ChIP-Seq_HESCs_Human1.27104584
76SA1_27219007_Chip-Seq_ERYTHROID_Human1.24384675
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.24017468
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21697878
79HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21695085
80CIITA_25753668_ChIP-Seq_RAJI_Human1.21140210
81CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.20978487
82RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20596592
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18302077
84RUNX1_22412390_ChIP-Seq_EML_Mouse1.18282020
85MYC_22102868_ChIP-Seq_BL_Human1.18204951
86MYB_26560356_Chip-Seq_TH2_Human1.16997410
87IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16752029
88MAF_26560356_Chip-Seq_TH1_Human1.16642029
89YY1_22570637_ChIP-Seq_MALME-3M_Human1.15861232
90RACK7_27058665_Chip-Seq_MCF-7_Human1.14997175
91PHF8_20622854_ChIP-Seq_HELA_Human1.13880131
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13744242
93* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13091564
94KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11632141
95VDR_24763502_ChIP-Seq_THP-1_Human1.10051246
96ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09651868
97CTCF_21964334_Chip-Seq_Bcells_Human1.09146153
98* MAF_26560356_Chip-Seq_TH2_Human1.08182545
99E2F1_20622854_ChIP-Seq_HELA_Human1.07921461
100SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07852778
101CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07548203
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06179740
103GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05472512
104UTX_26944678_Chip-Seq_JUKART_Human1.05297848
105POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04111652
106MYB_26560356_Chip-Seq_TH1_Human1.03273123
107KDM5A_27292631_Chip-Seq_BREAST_Human1.02810026
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02268335
109E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02205043
110E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02120272
111THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01828519
112PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01189712
113PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01079973
114SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00989886
115FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99985773
116MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99741608
117EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98218538
118RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96970058
119KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96066000
120CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93895941
121MYC_18940864_ChIP-ChIP_HL60_Human0.93468717
122GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93137716
123MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91291037
124CTCF_26484167_Chip-Seq_Bcells_Mouse0.91124627
125TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91082693
126NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89665195
127CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89619179
128* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89525343
129TFEB_21752829_ChIP-Seq_HELA_Human0.89233623
130STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.88810086
131HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87985927
132NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87852903
133LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87565212

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.76380413
2MP0005671_abnormal_response_to3.32358623
3MP0009379_abnormal_foot_pigmentation3.31896628
4MP0003763_abnormal_thymus_physiology3.25028140
5MP0009785_altered_susceptibility_to3.22454603
6MP0003806_abnormal_nucleotide_metabolis3.15190264
7MP0005451_abnormal_body_composition3.08117484
8MP0002148_abnormal_hypersensitivity_rea2.97239787
9MP0000685_abnormal_immune_system2.92486907
10MP0003436_decreased_susceptibility_to2.79939265
11MP0003693_abnormal_embryo_hatching2.76253914
12MP0005000_abnormal_immune_tolerance2.69561880
13MP0001800_abnormal_humoral_immune2.63909236
14MP0005025_abnormal_response_to2.62207738
15MP0009278_abnormal_bone_marrow2.59340789
16MP0009333_abnormal_splenocyte_physiolog2.56198060
17MP0001790_abnormal_immune_system2.55486446
18MP0005387_immune_system_phenotype2.55486446
19MP0002166_altered_tumor_susceptibility2.42531610
20MP0002723_abnormal_immune_serum2.41997997
21MP0002420_abnormal_adaptive_immunity2.40825677
22MP0001819_abnormal_immune_cell2.40124227
23MP0002452_abnormal_antigen_presenting2.37464109
24MP0002006_tumorigenesis2.32232857
25MP0004957_abnormal_blastocyst_morpholog2.22469787
26MP0003724_increased_susceptibility_to2.21484038
27MP0003866_abnormal_defecation2.20416188
28MP0010155_abnormal_intestine_physiology2.20348710
29MP0002398_abnormal_bone_marrow2.16698056
30MP0002405_respiratory_system_inflammati1.99183484
31MP0000716_abnormal_immune_system1.98472776
32MP0002419_abnormal_innate_immunity1.98128687
33MP0002396_abnormal_hematopoietic_system1.94293001
34MP0001873_stomach_inflammation1.90949901
35MP0000490_abnormal_crypts_of1.89994343
36MP0002722_abnormal_immune_system1.89060183
37MP0000689_abnormal_spleen_morphology1.81936377
38MP0001853_heart_inflammation1.79233340
39MP0002429_abnormal_blood_cell1.75274122
40MP0008260_abnormal_autophagy1.72349098
41MP0005083_abnormal_biliary_tract1.72103676
42MP0001845_abnormal_inflammatory_respons1.69074090
43MP0000858_altered_metastatic_potential1.66569946
44MP0006082_CNS_inflammation1.60714711
45MP0003186_abnormal_redox_activity1.60002312
46MP0005075_abnormal_melanosome_morpholog1.56124486
47MP0000703_abnormal_thymus_morphology1.49709179
48MP0002132_abnormal_respiratory_system1.46470480
49MP0003077_abnormal_cell_cycle1.46210898
50MP0004147_increased_porphyrin_level1.43337717
51MP0005464_abnormal_platelet_physiology1.43062197
52MP0002736_abnormal_nociception_after1.43060778
53MP0001661_extended_life_span1.42535500
54MP0004858_abnormal_nervous_system1.39937872
55MP0008469_abnormal_protein_level1.36692117
56MP0002163_abnormal_gland_morphology1.34643173
57MP0000678_abnormal_parathyroid_gland1.34005441
58MP0004947_skin_inflammation1.33591609
59MP0004185_abnormal_adipocyte_glucose1.33399117
60MP0005360_urolithiasis1.32102340
61MP0005397_hematopoietic_system_phenotyp1.31234731
62MP0001545_abnormal_hematopoietic_system1.31234731
63MP0002933_joint_inflammation1.29594477
64MP0004808_abnormal_hematopoietic_stem1.28932830
65MP0009840_abnormal_foam_cell1.27408565
66MP0005174_abnormal_tail_pigmentation1.26635381
67MP0003300_gastrointestinal_ulcer1.24571563
68MP0001663_abnormal_digestive_system1.24538077
69MP0001533_abnormal_skeleton_physiology1.20422503
70MP0005310_abnormal_salivary_gland1.17311160
71MP0002019_abnormal_tumor_incidence1.13743463
72MP0002009_preneoplasia1.13067615
73MP0005330_cardiomyopathy1.06534081
74MP0010094_abnormal_chromosome_stability1.05202867
75MP0008932_abnormal_embryonic_tissue1.03940505
76MP0003786_premature_aging1.03894336
77MP0008057_abnormal_DNA_replication1.03477609
78MP0000372_irregular_coat_pigmentation1.02600001
79MP0008789_abnormal_olfactory_epithelium1.02272938
80MP0006035_abnormal_mitochondrial_morpho1.01885217
81MP0003303_peritoneal_inflammation0.99797163
82MP0003718_maternal_effect0.99599924
83MP0001764_abnormal_homeostasis0.99530908
84MP0004510_myositis0.97806922
85MP0002277_abnormal_respiratory_mucosa0.97035331
86MP0003191_abnormal_cellular_cholesterol0.96407073
87MP0005584_abnormal_enzyme/coenzyme_acti0.95938325
88MP0008007_abnormal_cellular_replicative0.95403624
89MP0000358_abnormal_cell_content/0.93306408
90MP0000465_gastrointestinal_hemorrhage0.90972659
91MP0001968_abnormal_touch/_nociception0.90120058
92MP0001986_abnormal_taste_sensitivity0.89738028
93MP0000350_abnormal_cell_proliferation0.89627731
94MP0006036_abnormal_mitochondrial_physio0.89037894
95MP0003111_abnormal_nucleus_morphology0.88972399
96MP0005084_abnormal_gallbladder_morpholo0.88266646
97MP0003448_altered_tumor_morphology0.87502059
98MP0000750_abnormal_muscle_regeneration0.87170628
99MP0009643_abnormal_urine_homeostasis0.87016934
100MP0000015_abnormal_ear_pigmentation0.86994083
101MP0002653_abnormal_ependyma_morphology0.86456553
102MP0003315_abnormal_perineum_morphology0.85933647
103MP0008058_abnormal_DNA_repair0.85320776
104MP0000681_abnormal_thyroid_gland0.85275342
105MP0001730_embryonic_growth_arrest0.84988274
106MP0000477_abnormal_intestine_morphology0.84941570
107MP0001727_abnormal_embryo_implantation0.83402030
108MP0000313_abnormal_cell_death0.81620305
109MP0002638_abnormal_pupillary_reflex0.81487632
110MP0000003_abnormal_adipose_tissue0.81453952
111MP0005381_digestive/alimentary_phenotyp0.80174556
112MP0002095_abnormal_skin_pigmentation0.80028455
113MP0006292_abnormal_olfactory_placode0.76288104
114MP0009763_increased_sensitivity_to0.76199136
115MP0003878_abnormal_ear_physiology0.74833751
116MP0005377_hearing/vestibular/ear_phenot0.74833751
117MP0009764_decreased_sensitivity_to0.74272485
118MP0005501_abnormal_skin_physiology0.74157235
119MP0004381_abnormal_hair_follicle0.73877253
120MP0005332_abnormal_amino_acid0.73456824
121MP0006054_spinal_hemorrhage0.68484354
122MP0005058_abnormal_lysosome_morphology0.68225588
123MP0002080_prenatal_lethality0.67735075
124MP0005379_endocrine/exocrine_gland_phen0.65446990
125MP0005636_abnormal_mineral_homeostasis0.64203089
126MP0003656_abnormal_erythrocyte_physiolo0.63386988
127MP0001905_abnormal_dopamine_level0.63268560
128MP0001243_abnormal_dermal_layer0.62313219
129MP0000343_altered_response_to0.61941860
130MP0001348_abnormal_lacrimal_gland0.61193777
131MP0008872_abnormal_physiological_respon0.61190699

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.96723617
2Abnormal number of erythroid precursors (HP:0012131)5.22150442
3Elevated erythrocyte sedimentation rate (HP:0003565)4.37355234
4Mitochondrial inheritance (HP:0001427)4.24493439
5Hepatocellular necrosis (HP:0001404)4.13681523
6Reticulocytopenia (HP:0001896)3.98021702
7Macrocytic anemia (HP:0001972)3.95745594
8Acute necrotizing encephalopathy (HP:0006965)3.87629784
9Increased hepatocellular lipid droplets (HP:0006565)3.84465975
10IgM deficiency (HP:0002850)3.84270263
11Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.78870197
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.72828786
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.72828786
14Pallor (HP:0000980)3.67415106
15Increased CSF lactate (HP:0002490)3.67401257
16Exertional dyspnea (HP:0002875)3.60697291
17Abnormal mitochondria in muscle tissue (HP:0008316)3.54051967
18Hepatic necrosis (HP:0002605)3.53059869
19Petechiae (HP:0000967)3.43456546
20Recurrent abscess formation (HP:0002722)3.39546024
21Lipid accumulation in hepatocytes (HP:0006561)3.35963363
22Ragged-red muscle fibers (HP:0003200)3.30644445
23Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.26786661
24Thrombocytosis (HP:0001894)3.12998228
25Microvesicular hepatic steatosis (HP:0001414)3.09557039
26Eczematoid dermatitis (HP:0000976)3.03871825
27Progressive macrocephaly (HP:0004481)3.01479814
28Renal Fanconi syndrome (HP:0001994)3.01254151
29Acute encephalopathy (HP:0006846)2.92263905
30Recurrent bacterial skin infections (HP:0005406)2.90725382
31Progressive muscle weakness (HP:0003323)2.88252101
32Testicular atrophy (HP:0000029)2.86858688
33Rough bone trabeculation (HP:0100670)2.86479376
34Increased intramyocellular lipid droplets (HP:0012240)2.85758049
353-Methylglutaconic aciduria (HP:0003535)2.85735019
36Increased serum lactate (HP:0002151)2.85001909
37Hypertensive crisis (HP:0100735)2.84832753
38Abnormality of dicarboxylic acid metabolism (HP:0010995)2.82871416
39Dicarboxylic aciduria (HP:0003215)2.82871416
40Myositis (HP:0100614)2.82777268
41Chronic otitis media (HP:0000389)2.81813653
42IgG deficiency (HP:0004315)2.81243607
43Recurrent bronchitis (HP:0002837)2.73736566
44Pustule (HP:0200039)2.72078030
45Respiratory difficulties (HP:0002880)2.71023572
46Increased IgM level (HP:0003496)2.63149012
47Recurrent fungal infections (HP:0002841)2.53917612
48Obstructive lung disease (HP:0006536)2.53749729
49Chronic obstructive pulmonary disease (HP:0006510)2.53749729
50Abnormality of T cells (HP:0002843)2.53485853
51Respiratory failure (HP:0002878)2.53459286
52Lactic acidosis (HP:0003128)2.51471837
53Severe combined immunodeficiency (HP:0004430)2.46352554
54Abnormality of the heme biosynthetic pathway (HP:0010472)2.46269967
55Abnormality of T cell physiology (HP:0011840)2.45267967
56Cellulitis (HP:0100658)2.43565688
57Hypergammaglobulinemia (HP:0010702)2.41945037
58Aplastic anemia (HP:0001915)2.41932874
59Increased muscle lipid content (HP:0009058)2.41405073
60Hepatosplenomegaly (HP:0001433)2.40334449
61Cerebral palsy (HP:0100021)2.39808390
62Recurrent cutaneous fungal infections (HP:0011370)2.39379854
63Chronic mucocutaneous candidiasis (HP:0002728)2.39379854
64Mediastinal lymphadenopathy (HP:0100721)2.36785606
65Abnormality of macrophages (HP:0004311)2.35682559
66Exercise intolerance (HP:0003546)2.34795482
67Abnormality of T cell number (HP:0011839)2.34108559
68Abnormal trabecular bone morphology (HP:0100671)2.33788063
69Broad distal phalanx of finger (HP:0009836)2.33517591
70Recurrent viral infections (HP:0004429)2.31745867
71Reduced antithrombin III activity (HP:0001976)2.30770207
72Recurrent skin infections (HP:0001581)2.30444642
73Combined immunodeficiency (HP:0005387)2.30206035
74Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.29624302
75Abnormal protein N-linked glycosylation (HP:0012347)2.29624302
76Abnormal protein glycosylation (HP:0012346)2.29624302
77Abnormal glycosylation (HP:0012345)2.29624302
78Pancytopenia (HP:0001876)2.28010705
79Panhypogammaglobulinemia (HP:0003139)2.26243206
80T lymphocytopenia (HP:0005403)2.22794570
81Multiple enchondromatosis (HP:0005701)2.21279462
82Muscle fiber atrophy (HP:0100295)2.20938909
83Progressive microcephaly (HP:0000253)2.20824069
84Meningitis (HP:0001287)2.20699899
85Myopathic facies (HP:0002058)2.19951502
86Aplasia/Hypoplasia of the sacrum (HP:0008517)2.19246813
87Increased serum ferritin (HP:0003281)2.18349380
88Abnormality of reticulocytes (HP:0004312)2.16094630
89Colitis (HP:0002583)2.14587879
90Type I transferrin isoform profile (HP:0003642)2.14218612
91Abnormal hemoglobin (HP:0011902)2.11956758
92Vasculitis (HP:0002633)2.11496385
93Abnormality of small intestinal villus morphology (HP:0011472)2.11299937
94Villous atrophy (HP:0011473)2.11299937
95Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.10740404
96Agammaglobulinemia (HP:0004432)2.07452825
97Microretrognathia (HP:0000308)2.05820030
98Gastrointestinal inflammation (HP:0004386)2.05732676
99Prolonged neonatal jaundice (HP:0006579)2.05461826
100Vacuolated lymphocytes (HP:0001922)2.04925580
101Trismus (HP:0000211)2.03966395
102Stomatitis (HP:0010280)2.03582167
103Poikiloderma (HP:0001029)2.03495421
104Purpura (HP:0000979)2.03034604
105Premature ovarian failure (HP:0008209)2.02941201
106Nasal polyposis (HP:0100582)2.00535212
107Recurrent sinusitis (HP:0011108)2.00313962
108Abnormal delayed hypersensitivity skin test (HP:0002963)1.99988531
109Abnormality of eosinophils (HP:0001879)1.98310145
110Abnormal gallbladder physiology (HP:0012438)1.98025425
111Cholecystitis (HP:0001082)1.98025425
112Erythema (HP:0010783)1.98017724
113Rhabdomyolysis (HP:0003201)1.97917148
114Basal ganglia calcification (HP:0002135)1.95748717
115Urticaria (HP:0001025)1.95631007
116Abnormality of cells of the lymphoid lineage (HP:0012140)1.94074405
117Granulocytopenia (HP:0001913)1.93977631
118Abnormality of B cell number (HP:0010975)1.93710481
119B lymphocytopenia (HP:0010976)1.93710481
120Poor head control (HP:0002421)1.93447824
121Lymphopenia (HP:0001888)1.93382840
122Neutropenia (HP:0001875)1.92571173
123Autoimmune hemolytic anemia (HP:0001890)1.92149604
124Emotional lability (HP:0000712)1.91831279
125Chronic sinusitis (HP:0011109)1.90072317
126Eosinophilia (HP:0001880)1.89400365
127Lymphoma (HP:0002665)1.88870163
128Congenital ichthyosiform erythroderma (HP:0007431)1.88143826
129CNS demyelination (HP:0007305)1.87728705
130Encephalitis (HP:0002383)1.87626863
131Premature graying of hair (HP:0002216)1.87469212
132Abnormality of renal resorption (HP:0011038)1.87166635
133Abnormality of the umbilical cord (HP:0010881)1.85452430
134Lethargy (HP:0001254)1.84570709
135Cerebral edema (HP:0002181)1.83548904
136Cheilitis (HP:0100825)1.83541380
137Autoimmune thrombocytopenia (HP:0001973)1.82307690
138Seborrheic dermatitis (HP:0001051)1.77637907
139Death in infancy (HP:0001522)1.74727292
140Inflammation of the large intestine (HP:0002037)1.74524248
141Vertebral compression fractures (HP:0002953)1.74509411
142Abnormal umbilical cord blood vessels (HP:0011403)1.73578729
143Single umbilical artery (HP:0001195)1.73578729
144Abnormality of the fetal cardiovascular system (HP:0010948)1.73578729
145Acute hepatic failure (HP:0006554)1.72975768
146Decreased electroretinogram (ERG) amplitude (HP:0000654)1.72224929
147Progressive external ophthalmoplegia (HP:0000590)1.71401486

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.04721053
2VRK24.33559821
3BCKDK4.19535151
4MST43.48739300
5PIM23.38851502
6ERN13.26121806
7MAP3K123.15145481
8STK163.11862659
9MAP4K12.99726977
10BUB12.77314473
11TESK22.70911493
12ARAF2.24554515
13TEC2.20665984
14BLK2.15625348
15TXK2.10213720
16KDR2.02272399
17EIF2AK11.98352490
18ZAP701.94253573
19TBK11.93832383
20TYK21.78729776
21KIT1.78065026
22SMG11.77211967
23RAF11.64772154
24NUAK11.62701011
25TESK11.57751813
26EIF2AK31.56414678
27TLK11.55264232
28ILK1.53803226
29WEE11.47224788
30NME11.43035366
31SYK1.40832377
32MAP3K141.40085818
33IKBKE1.38258512
34TAOK21.35004167
35IRAK41.33501520
36GRK61.33205510
37LIMK11.29585623
38JAK31.29225551
39VRK11.29146881
40LRRK21.21981333
41TRIB31.20856699
42IKBKB1.15759817
43MYLK1.15639103
44RIPK41.09435179
45IRAK31.07848846
46BTK1.06407931
47MAP4K21.04553301
48MAP3K111.01596770
49CDC70.96704495
50ADRBK20.96452091
51EPHA20.95875043
52TSSK60.95104350
53ACVR1B0.90994245
54MAP2K20.90096723
55LCK0.89772017
56PRPF4B0.87195262
57SCYL20.85657848
58CDK190.83589262
59LYN0.83334017
60NEK10.82254946
61RPS6KA40.81579887
62RPS6KB20.80928878
63ATR0.80284719
64CCNB10.79591424
65PIM10.79559807
66SIK30.76101179
67CSNK1G30.75589178
68MUSK0.74563055
69MST1R0.74464063
70CSF1R0.74418512
71CDK70.72770435
72ABL20.72321384
73TNK20.72083643
74DAPK30.71951248
75MAP2K30.71115635
76BRAF0.70322859
77PAK10.68695370
78CDK80.68304814
79PDK20.65862149
80CHEK20.64165895
81ITK0.61452771
82NLK0.60733960
83SRPK10.60067093
84SIK10.58019834
85MAP2K60.57697338
86BMPR1B0.54966099
87FES0.53629902
88AURKB0.51046227
89MAPK110.50902163
90IRAK20.50754453
91STK100.50691913
92CSK0.50045643
93MAP3K10.49219787
94CSNK2A10.49137527
95CSNK1A1L0.48578825
96DYRK20.47797186
97FLT30.47547276
98TAOK30.46848913
99BMX0.46143973
100TGFBR10.46036793
101PLK10.45636075
102STK240.45449318
103PIK3CA0.44761512
104CSNK2A20.44435531
105PAK40.44183055
106CDK40.43310851
107MAPKAPK20.42189593
108CLK10.42097345
109STK40.41652257
110PLK40.41571741
111MOS0.40621988
112HCK0.40406557
113PRKCQ0.40193341
114MAPKAPK30.38575795
115MAP3K30.38525842
116PBK0.38485527
117PRKCI0.38185820
118TNIK0.38014025
119AURKA0.37836268
120DAPK10.37652510
121CDK90.37511163
122RPS6KA50.37463005
123PRKCD0.36914776
124GRK50.36779763
125DMPK0.36592334
126DYRK30.35910921
127STK38L0.35790618
128MATK0.34800397
129MAPK40.33700021
130EIF2AK20.33148209
131DYRK1B0.32788916
132PRKG20.31872327
133MAP3K80.31078401
134ADRBK10.30160114
135ZAK0.28692957

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.83923159
2Proteasome_Homo sapiens_hsa030504.77183742
3Oxidative phosphorylation_Homo sapiens_hsa001903.35866591
4Parkinsons disease_Homo sapiens_hsa050122.98816596
5RNA polymerase_Homo sapiens_hsa030202.95720921
6DNA replication_Homo sapiens_hsa030302.90655409
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.53744133
8Mismatch repair_Homo sapiens_hsa034302.28557220
9Primary immunodeficiency_Homo sapiens_hsa053402.25917794
10Huntingtons disease_Homo sapiens_hsa050162.09216551
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.04218998
12Alzheimers disease_Homo sapiens_hsa050102.03657921
13* Pyrimidine metabolism_Homo sapiens_hsa002402.01826910
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.99225008
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.94972324
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.87899681
17Protein export_Homo sapiens_hsa030601.87300842
18Spliceosome_Homo sapiens_hsa030401.84085660
19Biosynthesis of amino acids_Homo sapiens_hsa012301.73236773
20Fructose and mannose metabolism_Homo sapiens_hsa000511.69757520
21Homologous recombination_Homo sapiens_hsa034401.68338780
22Nucleotide excision repair_Homo sapiens_hsa034201.66257962
23Allograft rejection_Homo sapiens_hsa053301.57375821
24Sulfur metabolism_Homo sapiens_hsa009201.55911269
25Base excision repair_Homo sapiens_hsa034101.52190677
26Graft-versus-host disease_Homo sapiens_hsa053321.49355823
27Antigen processing and presentation_Homo sapiens_hsa046121.47701692
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44400375
29Leishmaniasis_Homo sapiens_hsa051401.40407600
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.32426125
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30414316
32Hematopoietic cell lineage_Homo sapiens_hsa046401.29709211
33Measles_Homo sapiens_hsa051621.29421300
34Carbon metabolism_Homo sapiens_hsa012001.27535739
35Fatty acid elongation_Homo sapiens_hsa000621.24841679
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23662657
37Sulfur relay system_Homo sapiens_hsa041221.22353156
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.18479141
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.17004079
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.15348835
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14115036
42Epstein-Barr virus infection_Homo sapiens_hsa051691.12716049
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10186083
44RNA transport_Homo sapiens_hsa030131.08914825
45Shigellosis_Homo sapiens_hsa051311.05532017
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.03224985
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00747844
48Pentose phosphate pathway_Homo sapiens_hsa000300.98777732
49Legionellosis_Homo sapiens_hsa051340.93110088
50Herpes simplex infection_Homo sapiens_hsa051680.93030452
51Asthma_Homo sapiens_hsa053100.92120505
52T cell receptor signaling pathway_Homo sapiens_hsa046600.89088913
53Autoimmune thyroid disease_Homo sapiens_hsa053200.87680043
54* Purine metabolism_Homo sapiens_hsa002300.87369412
55Non-homologous end-joining_Homo sapiens_hsa034500.84844882
56p53 signaling pathway_Homo sapiens_hsa041150.83493175
57Rheumatoid arthritis_Homo sapiens_hsa053230.82194253
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.78608505
59Pertussis_Homo sapiens_hsa051330.78290522
60Salmonella infection_Homo sapiens_hsa051320.77210127
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75944854
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74410668
63Folate biosynthesis_Homo sapiens_hsa007900.74149762
64Peroxisome_Homo sapiens_hsa041460.74054587
65Apoptosis_Homo sapiens_hsa042100.70908938
66Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70125551
67RNA degradation_Homo sapiens_hsa030180.69607518
68Cell cycle_Homo sapiens_hsa041100.67764585
69Basal transcription factors_Homo sapiens_hsa030220.64635531
70Pyruvate metabolism_Homo sapiens_hsa006200.64052590
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63424435
72Osteoclast differentiation_Homo sapiens_hsa043800.63293353
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60685073
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60568457
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59519567
76Type I diabetes mellitus_Homo sapiens_hsa049400.58742080
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58176568
78Other glycan degradation_Homo sapiens_hsa005110.57730601
79Phagosome_Homo sapiens_hsa041450.57178918
80Cardiac muscle contraction_Homo sapiens_hsa042600.56903450
81Tuberculosis_Homo sapiens_hsa051520.55967922
82Phenylalanine metabolism_Homo sapiens_hsa003600.55503057
83Influenza A_Homo sapiens_hsa051640.54701598
84* Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53361779
85Vibrio cholerae infection_Homo sapiens_hsa051100.52271085
86Collecting duct acid secretion_Homo sapiens_hsa049660.51421104
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.50846145
88B cell receptor signaling pathway_Homo sapiens_hsa046620.50629721
89Tyrosine metabolism_Homo sapiens_hsa003500.50479177
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49990138
91Alcoholism_Homo sapiens_hsa050340.49245870
92One carbon pool by folate_Homo sapiens_hsa006700.49242160
93Glutathione metabolism_Homo sapiens_hsa004800.48583510
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47628427
95Malaria_Homo sapiens_hsa051440.44495273
96Viral myocarditis_Homo sapiens_hsa054160.43960559
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43195915
98Toxoplasmosis_Homo sapiens_hsa051450.42831426
99Bladder cancer_Homo sapiens_hsa052190.40449245
100* Metabolic pathways_Homo sapiens_hsa011000.40024112
101Arginine biosynthesis_Homo sapiens_hsa002200.39347312
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.39315600
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39311843
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38588114
105Hepatitis B_Homo sapiens_hsa051610.38238236
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38033471
107Fanconi anemia pathway_Homo sapiens_hsa034600.37710213
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.36326440
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36283186
110TNF signaling pathway_Homo sapiens_hsa046680.35233441
111Systemic lupus erythematosus_Homo sapiens_hsa053220.33656611
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.33596821
113Lysosome_Homo sapiens_hsa041420.33250347
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32885666
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32584198
116Viral carcinogenesis_Homo sapiens_hsa052030.31988632
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31636466
118Renin-angiotensin system_Homo sapiens_hsa046140.31516020
119African trypanosomiasis_Homo sapiens_hsa051430.31513393
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30152121
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.30101904
122Arginine and proline metabolism_Homo sapiens_hsa003300.29580086
123Regulation of autophagy_Homo sapiens_hsa041400.29213111
124N-Glycan biosynthesis_Homo sapiens_hsa005100.28357808
125Arachidonic acid metabolism_Homo sapiens_hsa005900.28321053
126Galactose metabolism_Homo sapiens_hsa000520.27371010
127Acute myeloid leukemia_Homo sapiens_hsa052210.25294384
128Fatty acid metabolism_Homo sapiens_hsa012120.24680341
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24619592
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.23955511
131HTLV-I infection_Homo sapiens_hsa051660.23738919

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