NT5C1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytosolic nucleotidases, such as NT5C1A, dephosphorylate nucleoside monophosphates (Hunsucker et al., 2001 [PubMed 11133996]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)7.42850977
2response to muscle activity (GO:0014850)7.17919190
3positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)7.04380805
4skeletal muscle fiber development (GO:0048741)6.71280619
5cardiac myofibril assembly (GO:0055003)6.67058998
6myofibril assembly (GO:0030239)6.33572297
7regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.33451390
8negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.16569212
9regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.12056427
10myotube cell development (GO:0014904)6.10958392
11cardiac muscle contraction (GO:0060048)5.87076766
12actin-myosin filament sliding (GO:0033275)5.81775963
13muscle filament sliding (GO:0030049)5.81775963
14plasma membrane repair (GO:0001778)5.80289075
15negative regulation of potassium ion transmembrane transport (GO:1901380)5.67414059
16regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.63041738
17regulation of skeletal muscle contraction (GO:0014819)5.54798330
18regulation of actin filament-based movement (GO:1903115)5.40142151
19cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.37939978
20regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.36568666
21regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.32094947
22sarcoplasmic reticulum calcium ion transport (GO:0070296)5.25105485
23tricarboxylic acid cycle (GO:0006099)5.21582053
24glycogen biosynthetic process (GO:0005978)5.16813431
25glucan biosynthetic process (GO:0009250)5.16813431
26muscle fiber development (GO:0048747)5.07633660
27regulation of cell communication by electrical coupling (GO:0010649)5.03891526
28cellular polysaccharide catabolic process (GO:0044247)5.03119250
29ventricular cardiac muscle cell action potential (GO:0086005)5.00542833
30striated muscle contraction (GO:0006941)4.90798940
31skeletal muscle tissue development (GO:0007519)4.90220563
32cell communication involved in cardiac conduction (GO:0086065)4.89376527
33cell communication by electrical coupling (GO:0010644)4.82579895
34regulation of relaxation of muscle (GO:1901077)4.79479741
35actomyosin structure organization (GO:0031032)4.77941055
36actin-mediated cell contraction (GO:0070252)4.77442285
37carnitine shuttle (GO:0006853)4.68600736
38cardiac muscle cell development (GO:0055013)4.65683719
39regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.64858937
40skeletal muscle tissue regeneration (GO:0043403)4.57208267
41adult heart development (GO:0007512)4.56759885
42regulation of membrane repolarization (GO:0060306)4.54198105
43polysaccharide catabolic process (GO:0000272)4.53026030
44bundle of His cell to Purkinje myocyte communication (GO:0086069)4.47466934
45muscle cell cellular homeostasis (GO:0046716)4.44371584
46positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.42691422
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.40417615
48regulation of striated muscle contraction (GO:0006942)4.38738224
49cardiac cell development (GO:0055006)4.34416510
50regulation of acyl-CoA biosynthetic process (GO:0050812)4.34312935
51cardiac muscle hypertrophy (GO:0003300)4.22536390
52fructose metabolic process (GO:0006000)4.20175437
53cardiac muscle tissue morphogenesis (GO:0055008)4.15604883
54glycogen metabolic process (GO:0005977)4.15202816
55regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.07320736
56glucan metabolic process (GO:0044042)4.06966760
57cellular glucan metabolic process (GO:0006073)4.06966760
58striated muscle hypertrophy (GO:0014897)4.06064964
59regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.03960478
60gluconeogenesis (GO:0006094)4.02230098
61response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.99448577
62ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.98882591
63regulation of cardiac muscle cell contraction (GO:0086004)3.96883642
64fatty acid transmembrane transport (GO:1902001)3.95105116
65muscle organ morphogenesis (GO:0048644)3.93862473
66regulation of sarcomere organization (GO:0060297)3.93708420
67striated muscle cell development (GO:0055002)3.93429652
68regulation of cofactor metabolic process (GO:0051193)3.92845952
69regulation of coenzyme metabolic process (GO:0051196)3.92845952
70cardiac muscle cell action potential involved in contraction (GO:0086002)3.91780767
71regulation of the force of heart contraction (GO:0002026)3.90449050
72cardiac muscle cell action potential (GO:0086001)3.89966486
73muscle structure development (GO:0061061)3.89857950
74muscle organ development (GO:0007517)3.88216469
75response to activity (GO:0014823)3.85740052
76muscle cell fate commitment (GO:0042693)3.84277172
77positive regulation of myotube differentiation (GO:0010831)3.83491043
78striated muscle atrophy (GO:0014891)3.79898454
79regulation of calcium ion transmembrane transport (GO:1903169)3.79380010
80regulation of calcium ion transmembrane transporter activity (GO:1901019)3.79380010
81muscle adaptation (GO:0043500)3.77223196
82regulation of cardiac muscle contraction (GO:0055117)3.74997762
83positive regulation of cation channel activity (GO:2001259)3.74375223
84muscle tissue morphogenesis (GO:0060415)3.74127931
85skeletal muscle contraction (GO:0003009)3.72537022
86creatine metabolic process (GO:0006600)3.68471742
87IMP metabolic process (GO:0046040)3.65710928
88actin filament-based movement (GO:0030048)3.65552304
89cardiac conduction (GO:0061337)3.64373502
90myoblast fusion (GO:0007520)3.63418928
91relaxation of cardiac muscle (GO:0055119)3.61400117
92hexose biosynthetic process (GO:0019319)3.59148762
93NADH metabolic process (GO:0006734)3.58791430
94heart trabecula formation (GO:0060347)3.56620477
95potassium ion import (GO:0010107)3.54997488
96regulation of heart rate by cardiac conduction (GO:0086091)3.54569092
97regulation of heart rate (GO:0002027)3.54002090
98muscle hypertrophy (GO:0014896)3.53503469
99positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.52682323
100negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.51482620
101negative regulation of calcium ion transmembrane transport (GO:1903170)3.51482620
102detection of calcium ion (GO:0005513)3.50560033
103carnitine transmembrane transport (GO:1902603)3.46740930
104negative regulation of muscle contraction (GO:0045932)3.45965297
105response to inactivity (GO:0014854)3.45730148
106neuronal action potential propagation (GO:0019227)3.44825318
107regulation of skeletal muscle cell differentiation (GO:2001014)3.44743737
108negative regulation of protein localization to cell surface (GO:2000009)3.43646349
109muscle atrophy (GO:0014889)3.41873422
110regulation of myoblast differentiation (GO:0045661)3.37984802
111positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.37884641
112muscle cell development (GO:0055001)3.37228434
113negative regulation of potassium ion transport (GO:0043267)3.36255462
114regulation of heart contraction (GO:0008016)3.34758897
115heart process (GO:0003015)3.33665522
116heart contraction (GO:0060047)3.33665522
117striated muscle tissue development (GO:0014706)3.33442886
118positive regulation of potassium ion transmembrane transport (GO:1901381)3.33242251
119relaxation of muscle (GO:0090075)3.32173501
120negative regulation of cytosolic calcium ion concentration (GO:0051481)3.32132349
121ubiquinone biosynthetic process (GO:0006744)3.31885234
122skeletal muscle adaptation (GO:0043501)3.30943000
123muscle contraction (GO:0006936)3.30642456
124myotube differentiation (GO:0014902)3.29385567
125glycogen catabolic process (GO:0005980)3.26310815
126positive regulation of heart rate (GO:0010460)3.24714319
127cellular carbohydrate catabolic process (GO:0044275)3.22687952
128positive regulation of heart contraction (GO:0045823)3.22020243
129oxygen transport (GO:0015671)3.20929606
130regulation of sulfur metabolic process (GO:0042762)3.18517907
131syncytium formation by plasma membrane fusion (GO:0000768)3.18143859
132positive regulation of ion transmembrane transporter activity (GO:0032414)3.18007229
1332-oxoglutarate metabolic process (GO:0006103)3.17718375
134regulation of synapse structural plasticity (GO:0051823)3.16173168
135regulation of cation channel activity (GO:2001257)3.15554861
136amino-acid betaine transport (GO:0015838)3.14037932
137carnitine transport (GO:0015879)3.14037932
138cardiac muscle hypertrophy in response to stress (GO:0014898)3.10403784
139muscle hypertrophy in response to stress (GO:0003299)3.10403784
140cardiac muscle adaptation (GO:0014887)3.10403784
141muscle system process (GO:0003012)3.07197591
142glucan catabolic process (GO:0009251)3.04222769
143striated muscle adaptation (GO:0014888)3.02760969
144sodium ion export (GO:0071436)2.98902189

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.22669567
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.66640341
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.08535419
4EP300_21415370_ChIP-Seq_HL-1_Mouse3.06752966
5ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.91961435
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.42465135
7BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.39707152
8TBX20_22080862_ChIP-Seq_HEART_Mouse2.35254192
9TBX20_22328084_ChIP-Seq_HEART_Mouse2.35254192
10DROSHA_22980978_ChIP-Seq_HELA_Human2.33364895
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.29562903
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.25169876
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.12369152
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.09928874
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.09928874
16* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.09166166
17ZNF263_19887448_ChIP-Seq_K562_Human2.00772851
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.95467157
19CDX2_19796622_ChIP-Seq_MESCs_Mouse1.94133327
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.88192644
21EZH2_27294783_Chip-Seq_ESCs_Mouse1.85163666
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.83761139
23RARB_27405468_Chip-Seq_BRAIN_Mouse1.82249644
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.81135330
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.80938006
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.77891190
27NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.76943941
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.72119580
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.65529926
30EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.61113465
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60606314
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.59494215
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.59239130
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57832113
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55414581
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.48847234
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.47145410
38NFIB_24661679_ChIP-Seq_LUNG_Mouse1.45097939
39ZNF274_21170338_ChIP-Seq_K562_Hela1.44697573
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44048852
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.44027252
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.42630530
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.40422015
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.38845447
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38842413
46EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.38352881
47MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.36594349
48REST_18959480_ChIP-ChIP_MESCs_Mouse1.34420171
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32650396
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30230910
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.30040778
52GBX2_23144817_ChIP-Seq_PC3_Human1.29979950
53EED_16625203_ChIP-ChIP_MESCs_Mouse1.29417990
54* CTCF_27219007_Chip-Seq_Bcells_Human1.29191987
55NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.27830473
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23553516
57REST_21632747_ChIP-Seq_MESCs_Mouse1.21437555
58IGF1R_20145208_ChIP-Seq_DFB_Human1.19976805
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19942072
60KDM2B_26808549_Chip-Seq_K562_Human1.19573697
61* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17539936
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17035840
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.16080578
64AR_21572438_ChIP-Seq_LNCaP_Human1.15572399
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15046004
66STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.14342196
67SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11531857
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11071453
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10555274
70WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09802021
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.08795647
72CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06873007
73SMAD4_21799915_ChIP-Seq_A2780_Human1.05087086
74LXR_22292898_ChIP-Seq_THP-1_Human1.04918687
75SMC3_22415368_ChIP-Seq_MEFs_Mouse1.03723379
76CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02947726
77SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02589397
78CRX_20693478_ChIP-Seq_RETINA_Mouse1.02180385
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.00003572
80RING1B_27294783_Chip-Seq_ESCs_Mouse0.99536725
81SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99446381
82SMAD3_21741376_ChIP-Seq_HESCs_Human0.98863248
83* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.98586578
84TP63_22573176_ChIP-Seq_HFKS_Human0.98583401
85MYC_27129775_Chip-Seq_CORNEA_Mouse0.98477758
86SMAD4_21741376_ChIP-Seq_HESCs_Human0.98168952
87PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97178684
88AR_19668381_ChIP-Seq_PC3_Human0.96548442
89SA1_27219007_Chip-Seq_Bcells_Human0.96503167
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95654688
91WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95191549
92* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94719160
93OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94542583
94CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93690494
95ERG_21242973_ChIP-ChIP_JURKAT_Human0.93514714
96KDM2B_26808549_Chip-Seq_DND41_Human0.93155863
97EZH2_27294783_Chip-Seq_NPCs_Mouse0.92007989
98* OCT4_20526341_ChIP-Seq_ESCs_Human0.91384605
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90237489
100E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.89802115
101AHR_22903824_ChIP-Seq_MCF-7_Human0.89771788
102GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88841303
103* SPI1_20517297_ChIP-Seq_HL60_Human0.88613224
104PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88274117
105GATA4_21415370_ChIP-Seq_HL-1_Mouse0.88160874
106STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87029086
107PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86480626
108FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86479298
109SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85601120
110GATA1_19941826_ChIP-Seq_K562_Human0.83983761
111PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.83449515
112RXR_22158963_ChIP-Seq_LIVER_Mouse0.83077165
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83042413
114RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.82852638
115BCAT_22108803_ChIP-Seq_LS180_Human0.82812443
116HTT_18923047_ChIP-ChIP_STHdh_Human0.82476143
117SMC4_20622854_ChIP-Seq_HELA_Human0.81418457
118ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81122099
119STAT1_20625510_ChIP-Seq_HELA_Human0.80387576
120LXR_22158963_ChIP-Seq_LIVER_Mouse0.80344903
121CTBP1_25329375_ChIP-Seq_LNCAP_Human0.79985222
122PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.79540708
123DPY_21335234_ChIP-Seq_ESCs_Mouse0.79296397
124PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79071958
125STAT3_1855785_ChIP-Seq_MESCs_Mouse0.78888533
126KLF4_19829295_ChIP-Seq_ESCs_Human0.78395176
127TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.78103616
128TP53_20018659_ChIP-ChIP_R1E_Mouse0.77885726
129GATA2_21666600_ChIP-Seq_HMVEC_Human0.77552289
130NRF2_20460467_ChIP-Seq_MEFs_Mouse0.77237258
131NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.77237258
132CLOCK_20551151_ChIP-Seq_293T_Human0.77085690
133ARNT_22903824_ChIP-Seq_MCF-7_Human0.76897996
134TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76684976
135ISL1_27105846_Chip-Seq_CPCs_Mouse0.76467349
136* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.76154961
137* CTCF_21964334_Chip-Seq_Bcells_Human0.75900735
138RUNX1_27514584_Chip-Seq_MCF-7_Human0.75889816
139ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.75467799
140KLF5_20875108_ChIP-Seq_MESCs_Mouse0.75247602
141SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75189432
142FLI1_27457419_Chip-Seq_LIVER_Mouse0.74158830
143EGR1_19032775_ChIP-ChIP_M12_Human0.73847764
144NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.73776861
145VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.73735213
146PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.73371884
147GATA1_19941827_ChIP-Seq_MEL86_Mouse0.72532081
148* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.72201745
149GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.71593508
150GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.71231749
151RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.71136809
152SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.69052619
153TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.68596861
154LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.68582753
155ER_23166858_ChIP-Seq_MCF-7_Human0.67483792

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.44098362
2MP0003646_muscle_fatigue5.84673394
3MP0000751_myopathy5.41985641
4MP0004084_abnormal_cardiac_muscle4.65765686
5MP0004215_abnormal_myocardial_fiber4.32456622
6MP0004036_abnormal_muscle_relaxation3.97734623
7MP0000749_muscle_degeneration3.90989430
8MP0005451_abnormal_body_composition3.40067198
9MP0005330_cardiomyopathy3.24195006
10MP0004145_abnormal_muscle_electrophysio3.16029345
11MP0004087_abnormal_muscle_fiber2.85433356
12MP0003137_abnormal_impulse_conducting2.68945842
13MP0005620_abnormal_muscle_contractility2.66538650
14MP0002972_abnormal_cardiac_muscle2.65147811
15MP0002106_abnormal_muscle_physiology2.57479967
16MP0004130_abnormal_muscle_cell2.54918162
17MP0000750_abnormal_muscle_regeneration2.44484516
18MP0002269_muscular_atrophy2.39622797
19MP0008775_abnormal_heart_ventricle2.37604982
20MP0000747_muscle_weakness2.37025600
21MP0004484_altered_response_of2.29683807
22MP0005385_cardiovascular_system_phenoty2.15837067
23MP0001544_abnormal_cardiovascular_syste2.15837067
24MP0004859_abnormal_synaptic_plasticity2.15567637
25MP0002822_catalepsy2.11386697
26MP0000759_abnormal_skeletal_muscle2.10905448
27MP0005369_muscle_phenotype2.10195433
28MP0006138_congestive_heart_failure2.07093479
29MP0010630_abnormal_cardiac_muscle2.04649403
30MP0004085_abnormal_heartbeat2.02151117
31MP0004510_myositis1.91720393
32MP0004233_abnormal_muscle_weight1.81397038
33MP0003828_pulmonary_edema1.48557177
34MP0002332_abnormal_exercise_endurance1.47911559
35MP0006036_abnormal_mitochondrial_physio1.43052157
36MP0003221_abnormal_cardiomyocyte_apopto1.41866361
37MP0002127_abnormal_cardiovascular_syste1.26556265
38MP0005666_abnormal_adipose_tissue1.25583517
39MP0002909_abnormal_adrenal_gland1.25031715
40MP0003635_abnormal_synaptic_transmissio1.22109811
41MP0001661_extended_life_span1.13836735
42MP0009745_abnormal_behavioral_response1.11052799
43MP0002234_abnormal_pharynx_morphology1.09093115
44MP0004270_analgesia1.01533413
45MP0005670_abnormal_white_adipose1.01103732
46MP0008569_lethality_at_weaning1.00415661
47MP0002064_seizures0.98450138
48MP0009046_muscle_twitch0.96840005
49MP0003950_abnormal_plasma_membrane0.96005323
50MP0005165_increased_susceptibility_to0.94363329
51MP0002108_abnormal_muscle_morphology0.89968853
52MP0005375_adipose_tissue_phenotype0.89879104
53MP0003880_abnormal_central_pattern0.89164599
54MP0004185_abnormal_adipocyte_glucose0.88807997
55MP0004043_abnormal_pH_regulation0.87769274
56MP0004858_abnormal_nervous_system0.87682032
57MP0002272_abnormal_nervous_system0.87451071
58MP0002063_abnormal_learning/memory/cond0.86275869
59MP0006035_abnormal_mitochondrial_morpho0.85683081
60MP0005623_abnormal_meninges_morphology0.85564161
61MP0000343_altered_response_to0.85561438
62MP0003329_amyloid_beta_deposits0.84923712
63MP0000266_abnormal_heart_morphology0.84238249
64MP0005386_behavior/neurological_phenoty0.79802544
65MP0004924_abnormal_behavior0.79802544
66MP0000230_abnormal_systemic_arterial0.78868973
67MP0009780_abnormal_chondrocyte_physiolo0.74386179
68MP0000013_abnormal_adipose_tissue0.74311379
69MP0000372_irregular_coat_pigmentation0.72555762
70MP0010368_abnormal_lymphatic_system0.72139067
71MP0003879_abnormal_hair_cell0.71496724
72MP0002971_abnormal_brown_adipose0.68244571
73MP0001440_abnormal_grooming_behavior0.67001946
74MP0002572_abnormal_emotion/affect_behav0.66922061
75MP0003279_aneurysm0.64563943
76MP0005266_abnormal_metabolism0.64193671
77MP0002067_abnormal_sensory_capabilities0.63410185
78MP0004134_abnormal_chest_morphology0.62394592
79MP0001501_abnormal_sleep_pattern0.61929298
80MP0005187_abnormal_penis_morphology0.58784474
81MP0003045_fibrosis0.58573417
82MP0003567_abnormal_fetal_cardiomyocyte0.58249704
83MP0000003_abnormal_adipose_tissue0.57384613
84MP0005535_abnormal_body_temperature0.56468216
85MP0003656_abnormal_erythrocyte_physiolo0.55999793
86MP0001299_abnormal_eye_distance/0.55602087
87MP0002078_abnormal_glucose_homeostasis0.54673543
88MP0008874_decreased_physiological_sensi0.54584379
89MP0002735_abnormal_chemical_nociception0.53282130
90MP0001486_abnormal_startle_reflex0.52858243
91MP0002128_abnormal_blood_circulation0.52830485
92MP0008961_abnormal_basal_metabolism0.52120968
93MP0003705_abnormal_hypodermis_morpholog0.51837341
94MP0002066_abnormal_motor_capabilities/c0.49121200
95MP0004147_increased_porphyrin_level0.49093425
96MP0009672_abnormal_birth_weight0.48323413
97MP0000733_abnormal_muscle_development0.48267608
98MP0003633_abnormal_nervous_system0.48236575
99MP0005167_abnormal_blood-brain_barrier0.47864601
100MP0004142_abnormal_muscle_tone0.46710439
101MP0002638_abnormal_pupillary_reflex0.46068054
102MP0002734_abnormal_mechanical_nocicepti0.45501654
103MP0001346_abnormal_lacrimal_gland0.44943210
104MP0001970_abnormal_pain_threshold0.44454991
105MP0005584_abnormal_enzyme/coenzyme_acti0.42927563
106MP0005423_abnormal_somatic_nervous0.42284915
107MP0003075_altered_response_to0.39521558
108MP0003566_abnormal_cell_adhesion0.39388754
109MP0001529_abnormal_vocalization0.37212973
110MP0005376_homeostasis/metabolism_phenot0.36452459
111MP0005452_abnormal_adipose_tissue0.36358446
112MP0005166_decreased_susceptibility_to0.36344283
113MP0005595_abnormal_vascular_smooth0.34674061
114MP0005083_abnormal_biliary_tract0.34556474
115MP0003631_nervous_system_phenotype0.34152442
116MP0002733_abnormal_thermal_nociception0.34081038
117MP0002114_abnormal_axial_skeleton0.34003486
118MP0002184_abnormal_innervation0.33941141
119MP0000762_abnormal_tongue_morphology0.32221827
120MP0010030_abnormal_orbit_morphology0.31814971
121MP0003948_abnormal_gas_homeostasis0.30448712
122MP0009250_abnormal_appendicular_skeleto0.28878485
123MP0005334_abnormal_fat_pad0.27858090
124MP0006276_abnormal_autonomic_nervous0.25131823
125MP0001943_abnormal_respiration0.24023321
126MP0005319_abnormal_enzyme/_coenzyme0.23699569
127MP0005645_abnormal_hypothalamus_physiol0.23664487
128MP0005332_abnormal_amino_acid0.23467097
129MP0002896_abnormal_bone_mineralization0.23389457
130MP0002876_abnormal_thyroid_physiology0.14760088
131MP0003959_abnormal_lean_body0.14429836

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.52132813
2Exercise-induced myalgia (HP:0003738)6.66831540
3Calf muscle hypertrophy (HP:0008981)6.50558919
4Muscle hypertrophy of the lower extremities (HP:0008968)6.30542706
5Ventricular tachycardia (HP:0004756)6.22779755
6Exercise-induced muscle cramps (HP:0003710)6.22266354
7Distal arthrogryposis (HP:0005684)5.73739739
8Muscle fiber splitting (HP:0003555)5.58116532
9Atrial fibrillation (HP:0005110)5.42841450
10Abnormality of the calf musculature (HP:0001430)5.16395609
11Primary atrial arrhythmia (HP:0001692)5.11995530
12Hyporeflexia of lower limbs (HP:0002600)4.93752054
13Supraventricular tachycardia (HP:0004755)4.92354858
14Myoglobinuria (HP:0002913)4.90528557
15Centrally nucleated skeletal muscle fibers (HP:0003687)4.88256307
16Bundle branch block (HP:0011710)4.87581476
17Supraventricular arrhythmia (HP:0005115)4.81440598
18Right ventricular cardiomyopathy (HP:0011663)4.78020000
19Abnormality of the left ventricular outflow tract (HP:0011103)4.59971666
20Subaortic stenosis (HP:0001682)4.59971666
21Syncope (HP:0001279)4.58413658
22Round ear (HP:0100830)4.56597819
23Lipoatrophy (HP:0100578)4.44874576
24Difficulty running (HP:0009046)4.42246986
25EMG: myopathic abnormalities (HP:0003458)4.30683495
26Ulnar deviation of the wrist (HP:0003049)4.27172572
27Ventricular fibrillation (HP:0001663)4.24869177
28Palpitations (HP:0001962)4.08970092
29Prolonged QT interval (HP:0001657)4.08542826
30Myotonia (HP:0002486)4.04073384
31Ventricular arrhythmia (HP:0004308)3.97739973
32Increased connective tissue (HP:0009025)3.93432151
33Heart block (HP:0012722)3.82083570
34Calcaneovalgus deformity (HP:0001848)3.79822743
35Dilated cardiomyopathy (HP:0001644)3.78180496
36Asymmetric septal hypertrophy (HP:0001670)3.62766399
37Abnormal atrioventricular conduction (HP:0005150)3.58551927
38Rhabdomyolysis (HP:0003201)3.56470993
39Atrioventricular block (HP:0001678)3.50861363
40Absent phalangeal crease (HP:0006109)3.46671552
41Deformed tarsal bones (HP:0008119)3.36022146
42Abnormal EKG (HP:0003115)3.35486530
43Difficulty climbing stairs (HP:0003551)3.27392523
44Muscle stiffness (HP:0003552)3.10461777
45Malignant hyperthermia (HP:0002047)3.02353426
46Dysmetric saccades (HP:0000641)2.91191172
47Muscle fiber inclusion bodies (HP:0100299)2.89031095
48Abnormal finger flexion creases (HP:0006143)2.88711438
49Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.83923333
50Left ventricular hypertrophy (HP:0001712)2.82923238
51Increased variability in muscle fiber diameter (HP:0003557)2.82919525
52Slender build (HP:0001533)2.73137094
53Bulbar palsy (HP:0001283)2.62841629
54Type 1 muscle fiber predominance (HP:0003803)2.61542425
55Abnormality of skeletal muscle fiber size (HP:0012084)2.57478900
56Limb-girdle muscle atrophy (HP:0003797)2.57149610
57Fetal akinesia sequence (HP:0001989)2.52144264
58Neck muscle weakness (HP:0000467)2.51688021
59Weak cry (HP:0001612)2.39221851
60Areflexia of lower limbs (HP:0002522)2.36935795
61Palmoplantar keratoderma (HP:0000982)2.35436593
62Ketoacidosis (HP:0001993)2.34328001
63Distal lower limb muscle weakness (HP:0009053)2.34094770
64Spinal rigidity (HP:0003306)2.33287844
65Progressive muscle weakness (HP:0003323)2.32090216
66Muscular dystrophy (HP:0003560)2.22713917
67Fatigable weakness (HP:0003473)2.20532959
68Abnormality of the neuromuscular junction (HP:0003398)2.20532959
69Distal lower limb amyotrophy (HP:0008944)2.19812966
70Abnormality of the calcaneus (HP:0008364)2.17220696
71Testicular atrophy (HP:0000029)2.15766057
72Focal motor seizures (HP:0011153)2.13153253
73Abnormal mitochondria in muscle tissue (HP:0008316)2.11159489
74Hypoplastic ischia (HP:0003175)2.10729290
75Waddling gait (HP:0002515)2.09377120
76Nemaline bodies (HP:0003798)2.08043281
77Rimmed vacuoles (HP:0003805)2.05766680
78EMG: neuropathic changes (HP:0003445)2.03657686
79Hip contracture (HP:0003273)2.03651684
80Pheochromocytoma (HP:0002666)2.02934047
81Acute necrotizing encephalopathy (HP:0006965)2.00874809
82Lower limb amyotrophy (HP:0007210)1.99671572
83Proximal amyotrophy (HP:0007126)1.99072040
84Increased muscle lipid content (HP:0009058)1.97169549
85Abnormality of the shoulder girdle musculature (HP:0001435)1.95195284
86Hepatic necrosis (HP:0002605)1.94318428
87Gowers sign (HP:0003391)1.93743614
88Mildly elevated creatine phosphokinase (HP:0008180)1.92614277
89Sudden cardiac death (HP:0001645)1.92522802
90Abnormality of the foot musculature (HP:0001436)1.92204691
91Facial diplegia (HP:0001349)1.91828924
92Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.91446529
93Foot dorsiflexor weakness (HP:0009027)1.90145903
94Abnormality of the hip-girdle musculature (HP:0001445)1.89953301
95Abnormality of the musculature of the pelvis (HP:0001469)1.89953301
96Shoulder girdle muscle weakness (HP:0003547)1.87462989
97Pelvic girdle muscle weakness (HP:0003749)1.86701821
98Respiratory insufficiency due to muscle weakness (HP:0002747)1.84496207
99Scapular winging (HP:0003691)1.84357241
100Large for gestational age (HP:0001520)1.82625889
101Myokymia (HP:0002411)1.81233802
102Athetosis (HP:0002305)1.80871776
103Abnormality of the ischium (HP:0003174)1.80674484
104Central scotoma (HP:0000603)1.79416870
105Ragged-red muscle fibers (HP:0003200)1.78545111
106Neuroendocrine neoplasm (HP:0100634)1.77849802
107Acute encephalopathy (HP:0006846)1.77309390
108Myopathic facies (HP:0002058)1.76117775
109Hepatocellular necrosis (HP:0001404)1.75680373
110Long clavicles (HP:0000890)1.75667106
111Frequent falls (HP:0002359)1.74999116
112Rapidly progressive (HP:0003678)1.73854176
113Broad metatarsal (HP:0001783)1.73590415
114Congestive heart failure (HP:0001635)1.73413116
115Paralysis (HP:0003470)1.73112711
116Limb-girdle muscle weakness (HP:0003325)1.70437603
117Increased intramyocellular lipid droplets (HP:0012240)1.70021952
118Generalized muscle weakness (HP:0003324)1.68414346
119Bradycardia (HP:0001662)1.67919239
120Progressive macrocephaly (HP:0004481)1.67515732
121Hyperkalemia (HP:0002153)1.66956716
122Nonprogressive disorder (HP:0003680)1.65736287
123Conjunctival hamartoma (HP:0100780)1.64661872
124Ketosis (HP:0001946)1.63795840
125Visual hallucinations (HP:0002367)1.62981142
126Dysdiadochokinesis (HP:0002075)1.61329187
127Cholelithiasis (HP:0001081)1.60059345
128Oligomenorrhea (HP:0000876)1.59722924
129Mitochondrial inheritance (HP:0001427)1.59423694
130Exercise intolerance (HP:0003546)1.58509269
131Metatarsus adductus (HP:0001840)1.50082114
132Ulnar deviation of finger (HP:0009465)1.49236311
133Type 2 muscle fiber atrophy (HP:0003554)1.44411383
134Steppage gait (HP:0003376)1.42546447
135Popliteal pterygium (HP:0009756)1.41432443
136Insulin-resistant diabetes mellitus (HP:0000831)1.35471894
137Limited hip movement (HP:0008800)1.34935137
138Muscle fiber atrophy (HP:0100295)1.33871790
139Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.24754466
140Congenital hip dislocation (HP:0001374)1.24167939
141Diaphragmatic weakness (HP:0009113)1.23393597
142Achilles tendon contracture (HP:0001771)1.23369482
143Abnormality of potassium homeostasis (HP:0011042)1.20089397

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.38749086
2PHKG24.74396138
3PHKG14.74396138
4OBSCN3.82554756
5LMTK23.79810152
6DMPK2.77245157
7MYLK2.71395915
8PDK42.69756152
9PDK32.69756152
10PIK3CG2.65738883
11PINK12.30332943
12PKN22.12717690
13TRIB32.10637252
14PIK3CA2.01228672
15NEK11.93818503
16MUSK1.90424060
17BCKDK1.71125074
18PDK21.62476578
19MAP3K71.56611196
20NTRK31.47199244
21PAK31.45966937
22GRK71.42860884
23CAMK2D1.37956597
24RIPK11.37023939
25NME11.31355347
26TIE11.27325232
27EPHA41.21152625
28STK241.17860497
29EEF2K1.12214944
30MAPK121.08639305
31MAP3K41.08025628
32PRKD11.06782639
33STK381.05749283
34CCNB11.00083410
35PRKAA10.99162573
36PRPF4B0.99162222
37MAP2K40.97165496
38MAP3K90.95351087
39LIMK10.95029726
40PRKCH0.93885978
41PAK60.91037261
42CDC42BPA0.90153190
43CAMK2A0.86372614
44KSR20.86308162
45PKN10.82311445
46CAMK10.82293021
47PRKAA20.82174860
48ROCK10.80390633
49CAMK40.78712094
50WNK10.77587257
51MOS0.76468924
52ERBB30.75386257
53PTK2B0.71991679
54EPHB10.70304096
55PDGFRA0.69544210
56ROCK20.69287471
57PRKD30.67723113
58MAP3K50.67403171
59MAP3K130.66744093
60ILK0.64766776
61MAP2K30.64537091
62PDPK10.64527472
63CAMK2G0.61927562
64AKT20.61587112
65DYRK1B0.61231460
66NEK90.60524990
67PRKACB0.60172085
68CAMKK10.60154180
69INSRR0.59706795
70WNK40.58224602
71MAPK70.57737405
72PRKCE0.57683758
73PDK10.57568472
74DAPK30.55512705
75DAPK20.55400940
76SGK30.53685955
77MAPK110.53104846
78TRPM70.52277983
79ALK0.50446230
80NTRK20.50363355
81PRKACG0.49935217
82MAPK40.48926446
83PRKACA0.48264379
84MARK10.47680929
85ICK0.47334641
86SGK10.47313712
87TAOK10.46831511
88STK110.46364833
89MAP3K10.45916803
90JAK10.45170872
91MINK10.43726347
92CAMKK20.43088322
93CAMK2B0.42512987
94RET0.42133274
95GRK50.41077130
96FER0.41032286
97CDK50.40240735
98RPS6KA30.39733742
99PTK60.38594277
100MAP2K70.37929243
101NTRK10.37147687
102SGK20.34776487
103LATS20.34577763
104MAPKAPK30.34466665
105RPS6KC10.33772109
106RPS6KL10.33772109
107PRKCG0.32312780
108PRKG10.30432077
109SGK2230.29363653
110SGK4940.29363653
111MAP2K60.29318572
112MAP2K10.28962329
113TBK10.28601947
114UHMK10.27860916
115MAPK130.26506347
116RPS6KB10.26155036
117MAPK100.23927522
118TAOK20.23743751
119CDK190.22367314
120MARK20.21533714
121EPHA30.21140460
122RPS6KA10.19508855
123SIK10.18070674
124ARAF0.16464869
125MAP3K100.16391614
126RPS6KB20.14636137
127MAP3K110.12059550
128MTOR0.11663376
129ZAP700.10565236
130MARK30.09104983
131RAF10.08340252
132RPS6KA60.07690867
133FGFR30.05941134
134MAP3K60.04239614
135BRAF0.03792944
136GSK3B0.03569509
137MAPK90.03406988
138NLK0.02766967
139MAPK80.02624088
140PRKDC0.02330574
141LATS10.01961661

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.64019645
2Cardiac muscle contraction_Homo sapiens_hsa042603.66967198
3Dilated cardiomyopathy_Homo sapiens_hsa054143.43554077
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.42539248
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.27544050
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.24071737
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.45314176
8Propanoate metabolism_Homo sapiens_hsa006402.30288036
9Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.16631643
10Pentose phosphate pathway_Homo sapiens_hsa000302.09120850
11Oxidative phosphorylation_Homo sapiens_hsa001902.04347206
12Parkinsons disease_Homo sapiens_hsa050121.99884886
13Fatty acid degradation_Homo sapiens_hsa000711.84081606
14Carbon metabolism_Homo sapiens_hsa012001.74138035
15Alzheimers disease_Homo sapiens_hsa050101.69334669
16Calcium signaling pathway_Homo sapiens_hsa040201.48631495
17Fatty acid metabolism_Homo sapiens_hsa012121.48322085
18Circadian entrainment_Homo sapiens_hsa047131.39595338
19Gastric acid secretion_Homo sapiens_hsa049711.35475276
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34612981
21Oxytocin signaling pathway_Homo sapiens_hsa049211.30096641
22cGMP-PKG signaling pathway_Homo sapiens_hsa040221.27717848
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23965360
24Insulin secretion_Homo sapiens_hsa049111.22804520
25Viral myocarditis_Homo sapiens_hsa054161.20116920
26Pyruvate metabolism_Homo sapiens_hsa006201.19131969
27Nicotine addiction_Homo sapiens_hsa050331.14905767
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.14201405
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13758173
30Glucagon signaling pathway_Homo sapiens_hsa049221.13662605
31Type II diabetes mellitus_Homo sapiens_hsa049301.12801083
32Huntingtons disease_Homo sapiens_hsa050161.11504878
33Salivary secretion_Homo sapiens_hsa049701.10914615
34Nitrogen metabolism_Homo sapiens_hsa009101.06662244
35Olfactory transduction_Homo sapiens_hsa047401.06389942
36GABAergic synapse_Homo sapiens_hsa047271.06331576
37Renin secretion_Homo sapiens_hsa049241.05760039
38Long-term potentiation_Homo sapiens_hsa047201.05700505
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04507238
40Morphine addiction_Homo sapiens_hsa050321.00933544
41Butanoate metabolism_Homo sapiens_hsa006501.00281142
42Taste transduction_Homo sapiens_hsa047421.00241063
43Insulin resistance_Homo sapiens_hsa049310.98139310
44Adipocytokine signaling pathway_Homo sapiens_hsa049200.98094768
45Insulin signaling pathway_Homo sapiens_hsa049100.97408325
46Cholinergic synapse_Homo sapiens_hsa047250.93244770
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.92631917
48cAMP signaling pathway_Homo sapiens_hsa040240.92149493
49Starch and sucrose metabolism_Homo sapiens_hsa005000.91835575
50Glutamatergic synapse_Homo sapiens_hsa047240.91445392
51Arginine biosynthesis_Homo sapiens_hsa002200.90298410
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85736995
53GnRH signaling pathway_Homo sapiens_hsa049120.84831402
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83639594
55Synaptic vesicle cycle_Homo sapiens_hsa047210.81715478
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79553149
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73686995
58Dopaminergic synapse_Homo sapiens_hsa047280.72758825
59PPAR signaling pathway_Homo sapiens_hsa033200.70717828
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70562676
61Amphetamine addiction_Homo sapiens_hsa050310.70551672
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70117128
63Fatty acid biosynthesis_Homo sapiens_hsa000610.70073947
64Biosynthesis of amino acids_Homo sapiens_hsa012300.68735759
65AMPK signaling pathway_Homo sapiens_hsa041520.67194785
66Gap junction_Homo sapiens_hsa045400.66048150
67Pancreatic secretion_Homo sapiens_hsa049720.64678849
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64040888
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61343507
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61155538
71FoxO signaling pathway_Homo sapiens_hsa040680.57815655
72HIF-1 signaling pathway_Homo sapiens_hsa040660.57434009
73Fatty acid elongation_Homo sapiens_hsa000620.56823874
74Focal adhesion_Homo sapiens_hsa045100.56014344
75Galactose metabolism_Homo sapiens_hsa000520.54144638
76Serotonergic synapse_Homo sapiens_hsa047260.53156798
77Estrogen signaling pathway_Homo sapiens_hsa049150.52991697
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52907675
79Tight junction_Homo sapiens_hsa045300.51303213
80* Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50713042
81Arginine and proline metabolism_Homo sapiens_hsa003300.50584151
82Dorso-ventral axis formation_Homo sapiens_hsa043200.49966483
83Long-term depression_Homo sapiens_hsa047300.49964583
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49848839
85Circadian rhythm_Homo sapiens_hsa047100.48425543
86Collecting duct acid secretion_Homo sapiens_hsa049660.48342219
87Bile secretion_Homo sapiens_hsa049760.47391989
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45412409
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45349448
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44442084
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44361129
92beta-Alanine metabolism_Homo sapiens_hsa004100.44353712
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.41008179
94Fructose and mannose metabolism_Homo sapiens_hsa000510.39607660
95Phenylalanine metabolism_Homo sapiens_hsa003600.38098988
96Lysine degradation_Homo sapiens_hsa003100.36146608
97Amoebiasis_Homo sapiens_hsa051460.36040846
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35228491
99VEGF signaling pathway_Homo sapiens_hsa043700.33757082
100MAPK signaling pathway_Homo sapiens_hsa040100.33593670
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.33303774
102Peroxisome_Homo sapiens_hsa041460.32357842
103Cocaine addiction_Homo sapiens_hsa050300.31521721
104Ovarian steroidogenesis_Homo sapiens_hsa049130.31492216
105Tryptophan metabolism_Homo sapiens_hsa003800.31214741
106mTOR signaling pathway_Homo sapiens_hsa041500.30237286
107Melanogenesis_Homo sapiens_hsa049160.29622388
108Thyroid hormone synthesis_Homo sapiens_hsa049180.28897574
109Regulation of autophagy_Homo sapiens_hsa041400.27592256
110Glioma_Homo sapiens_hsa052140.25549424
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22813281
112Tyrosine metabolism_Homo sapiens_hsa003500.22213093
113Platelet activation_Homo sapiens_hsa046110.19763233
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.17339767
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16030726
116Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.15890826
117Thyroid cancer_Homo sapiens_hsa052160.14817395
118Adherens junction_Homo sapiens_hsa045200.13816354
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.13640950
120Histidine metabolism_Homo sapiens_hsa003400.13450867
121Oocyte meiosis_Homo sapiens_hsa041140.12270380
122Renal cell carcinoma_Homo sapiens_hsa052110.06193086

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