NT5C1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytosolic 5-prime nucleotidases, such as NT5C1B, catalyze production of adenosine, which regulates diverse physiologic processes (Sala-Newby and Newby, 2001 [PubMed 11690631]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.93109035
2spermatid development (GO:0007286)9.91202115
3reproduction (GO:0000003)9.52404326
4cilium or flagellum-dependent cell motility (GO:0001539)9.40275085
5motile cilium assembly (GO:0044458)9.36716277
6regulation of cilium movement (GO:0003352)9.07507000
7cilium movement (GO:0003341)8.22241939
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.58846791
9single fertilization (GO:0007338)7.53871831
10sperm capacitation (GO:0048240)7.50960680
11protein targeting to Golgi (GO:0000042)7.34943457
12negative regulation of inclusion body assembly (GO:0090084)7.33857902
13response to pheromone (GO:0019236)7.25727505
14establishment of protein localization to Golgi (GO:0072600)7.20166333
15synaptonemal complex organization (GO:0070193)7.05656967
16male meiosis (GO:0007140)6.97827709
17retrograde transport, vesicle recycling within Golgi (GO:0000301)6.92279138
18synaptonemal complex assembly (GO:0007130)6.88666066
19piRNA metabolic process (GO:0034587)6.86779725
20spermatogenesis (GO:0007283)6.77918009
21male gamete generation (GO:0048232)6.75563689
22rRNA methylation (GO:0031167)6.67788103
23microtubule depolymerization (GO:0007019)6.65031809
24organic cation transport (GO:0015695)6.63480730
25phosphatidylethanolamine biosynthetic process (GO:0006646)6.55724810
26fertilization (GO:0009566)6.38057509
27gamete generation (GO:0007276)6.20711492
28regulation of inclusion body assembly (GO:0090083)6.08815172
29phosphatidylethanolamine metabolic process (GO:0046337)6.02655675
30rRNA modification (GO:0000154)5.72907369
31cellular ketone body metabolic process (GO:0046950)5.70040047
32calcium ion-dependent exocytosis (GO:0017156)5.63457271
33germ cell development (GO:0007281)5.49710960
34cellular process involved in reproduction in multicellular organism (GO:0022412)5.40858588
35protein localization to Golgi apparatus (GO:0034067)5.40197997
36regulation of microtubule-based movement (GO:0060632)5.37117073
37ventricular system development (GO:0021591)5.30773982
38chromosome condensation (GO:0030261)5.14870698
39glycerol ether metabolic process (GO:0006662)5.12691243
40positive regulation of Rab GTPase activity (GO:0032851)5.08795015
41regulation of Rab GTPase activity (GO:0032313)5.08795015
42cell recognition (GO:0008037)5.05112122
43spermatid nucleus differentiation (GO:0007289)5.01607409
44ketone body metabolic process (GO:1902224)4.96076306
45multicellular organismal reproductive process (GO:0048609)4.90281527
46DNA packaging (GO:0006323)4.87729550
47male meiosis I (GO:0007141)4.83103601
48microtubule severing (GO:0051013)4.80058191
49ether metabolic process (GO:0018904)4.73940919
50chromosome organization involved in meiosis (GO:0070192)4.67116251
51coenzyme catabolic process (GO:0009109)4.60784921
52centriole replication (GO:0007099)4.59215378
53seminiferous tubule development (GO:0072520)4.59048118
54left/right pattern formation (GO:0060972)4.51697544
55regulation of transcription involved in cell fate commitment (GO:0060850)4.47046455
56centriole assembly (GO:0098534)4.46005172
57DNA methylation involved in gamete generation (GO:0043046)4.39958819
58sexual reproduction (GO:0019953)4.32462341
59meiotic nuclear division (GO:0007126)4.14009870
60chaperone-mediated protein complex assembly (GO:0051131)4.12140505
61single strand break repair (GO:0000012)4.08477963
62Golgi to endosome transport (GO:0006895)3.97048658
63multicellular organismal development (GO:0007275)3.94407578
64multicellular organismal movement (GO:0050879)3.87833035
65musculoskeletal movement (GO:0050881)3.87833035
66meiosis I (GO:0007127)3.84550083
67genitalia morphogenesis (GO:0035112)3.69981996
68protein polyglutamylation (GO:0018095)3.61985591
69regulation of centriole replication (GO:0046599)3.59397568
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.52462192
71protein K11-linked deubiquitination (GO:0035871)3.41798924
72protein refolding (GO:0042026)3.41149149
73microtubule polymerization or depolymerization (GO:0031109)3.39607500
74monoubiquitinated protein deubiquitination (GO:0035520)3.38156356
75intra-Golgi vesicle-mediated transport (GO:0006891)3.37059434
76peptidyl-threonine dephosphorylation (GO:0035970)3.36939932
77glycolytic process (GO:0006096)3.30848482
78sequestering of actin monomers (GO:0042989)3.29351482
79regulation of spindle checkpoint (GO:0090231)3.28905621
80meiotic cell cycle (GO:0051321)3.28024226
81mitochondrial fission (GO:0000266)3.27858227
82histone mRNA catabolic process (GO:0071044)3.17423522
83negative regulation of Rho protein signal transduction (GO:0035024)3.15799333
84protein localization to cilium (GO:0061512)3.14098591
85cellular response to pH (GO:0071467)3.13280334
86carnitine transport (GO:0015879)3.09466975
87amino-acid betaine transport (GO:0015838)3.09466975
88nucleus organization (GO:0006997)3.08772331
89nucleoside diphosphate phosphorylation (GO:0006165)3.07159891
90mitotic sister chromatid cohesion (GO:0007064)3.06019788
91response to acidic pH (GO:0010447)3.04366181
92polyol catabolic process (GO:0046174)3.03733209
93glomerular visceral epithelial cell development (GO:0072015)3.01163273
94microtubule nucleation (GO:0007020)2.98789368
95alditol metabolic process (GO:0019400)2.94269700
96regulation of interleukin-13 production (GO:0032656)2.91749808
97membrane protein intracellular domain proteolysis (GO:0031293)2.91689793
98carnitine transmembrane transport (GO:1902603)2.90770370
99regulation of phosphoprotein phosphatase activity (GO:0043666)2.90669279
100positive regulation of guanylate cyclase activity (GO:0031284)2.90099953
101glomerular epithelial cell development (GO:0072310)2.88175912
102RNA localization (GO:0006403)2.85839817
103cofactor catabolic process (GO:0051187)2.85821602
104interferon-gamma secretion (GO:0072643)2.84870845
105GTP biosynthetic process (GO:0006183)2.83466757
106cilium organization (GO:0044782)2.82377164
107regulation of female gonad development (GO:2000194)2.80181308
108microtubule-based movement (GO:0007018)2.79675839
109protein depolymerization (GO:0051261)2.78557372
110positive regulation of macrophage activation (GO:0043032)2.77841172
111mesenchymal cell differentiation involved in kidney development (GO:0072161)2.77660079
112mesenchymal cell differentiation involved in renal system development (GO:2001012)2.77660079
113cellular zinc ion homeostasis (GO:0006882)2.77498270
114cerebral cortex neuron differentiation (GO:0021895)2.76868461
115polyamine biosynthetic process (GO:0006596)2.76378448
116alanine transport (GO:0032328)2.75936586
117regulation of somitogenesis (GO:0014807)2.74185230
118meiotic cell cycle process (GO:1903046)2.73620444
119RNA destabilization (GO:0050779)2.72928939
120regulation of guanylate cyclase activity (GO:0031282)2.71630305
121cilium assembly (GO:0042384)2.71218873
122synapsis (GO:0007129)2.67656171
123regulation of cilium assembly (GO:1902017)2.66442275
124cellular component assembly involved in morphogenesis (GO:0010927)2.66402285
125negative regulation of organelle assembly (GO:1902116)2.63319073
126cilium morphogenesis (GO:0060271)2.63269273
127intraciliary transport (GO:0042073)2.63252830
128lactate metabolic process (GO:0006089)2.61368180
129chromatin silencing (GO:0006342)2.61102443
130axoneme assembly (GO:0035082)2.58009264
131UTP biosynthetic process (GO:0006228)2.53395115
132mitochondrion degradation (GO:0000422)2.52074249
133peptidyl-glutamic acid modification (GO:0018200)2.51364753
134positive regulation of glycolytic process (GO:0045821)2.45871295
135sperm motility (GO:0030317)14.4920948
136fusion of sperm to egg plasma membrane (GO:0007342)13.4639788
137cell wall macromolecule catabolic process (GO:0016998)12.4689194
138cell wall macromolecule metabolic process (GO:0044036)12.4689194
139acrosome reaction (GO:0007340)12.3660448
140sperm-egg recognition (GO:0035036)11.5978236
141acrosome assembly (GO:0001675)11.4068908
142multicellular organism reproduction (GO:0032504)11.0095917
143binding of sperm to zona pellucida (GO:0007339)10.5826566
144cell-cell recognition (GO:0009988)10.3817875
145plasma membrane fusion (GO:0045026)10.2619064
146epithelial cilium movement (GO:0003351)10.1360951

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.20779968
2EZH2_22144423_ChIP-Seq_EOC_Human4.43156598
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.09662107
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.21096636
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.02247089
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.91514152
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.73912447
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.70327570
9VDR_22108803_ChIP-Seq_LS180_Human2.58666284
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.51953947
11VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.37808677
12CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.24551970
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.23787938
14FUS_26573619_Chip-Seq_HEK293_Human2.20959676
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.20701613
16GATA1_26923725_Chip-Seq_HPCs_Mouse2.16893616
17EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.07157383
18ER_23166858_ChIP-Seq_MCF-7_Human2.05377649
19ZNF274_21170338_ChIP-Seq_K562_Hela2.04746437
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00837623
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.97113859
22TP53_18474530_ChIP-ChIP_U2OS_Human1.89304386
23ARNT_22903824_ChIP-Seq_MCF-7_Human1.84647334
24KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.79834339
25FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76804518
26ELK4_26923725_Chip-Seq_MESODERM_Mouse1.74679678
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.72099772
28RAC3_21632823_ChIP-Seq_H3396_Human1.70430369
29* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.69677643
30MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.69322034
31* STAT1_17558387_ChIP-Seq_HELA_Human1.67824103
32ERA_21632823_ChIP-Seq_H3396_Human1.65840245
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65791497
34SOX2_22085726_ChIP-Seq_NPCs_Mouse1.65527886
35* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.64942642
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60410378
37WDR5_24793694_ChIP-Seq_LNCAP_Human1.56503114
38GATA3_21867929_ChIP-Seq_CD8_Mouse1.53699040
39DROSHA_22980978_ChIP-Seq_HELA_Human1.53470395
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.51998401
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.51146719
42* AR_25329375_ChIP-Seq_VCAP_Human1.51037348
43RUNX_20019798_ChIP-Seq_JUKART_Human1.50754072
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.50445926
45* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.49051491
46ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46793454
47ETV2_25802403_ChIP-Seq_MESCs_Mouse1.45740326
48* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45280989
49HNFA_21074721_ChIP-Seq_CACO-2_Human1.45253906
50RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.44401808
51P300_19829295_ChIP-Seq_ESCs_Human1.44119097
52PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.43275877
53* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.43099686
54PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.42465727
55AUTS2_25519132_ChIP-Seq_293T-REX_Human1.42363581
56FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.41652097
57* KDM2B_26808549_Chip-Seq_REH_Human1.41036242
58* ETV1_20927104_ChIP-Seq_GIST48_Human1.39342446
59* SMAD4_21741376_ChIP-Seq_EPCs_Human1.38379993
60P53_21459846_ChIP-Seq_SAOS-2_Human1.37556667
61EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.37029743
62* TAL1_26923725_Chip-Seq_HPCs_Mouse1.37026753
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.36931597
64KAP1_22055183_ChIP-Seq_ESCs_Mouse1.36892281
65TDRD3_21172665_ChIP-Seq_MCF-7_Human1.35622469
66SMAD4_21799915_ChIP-Seq_A2780_Human1.34801444
67MYC_19829295_ChIP-Seq_ESCs_Human1.34677666
68REST_21632747_ChIP-Seq_MESCs_Mouse1.34064533
69* RBPJ_21746931_ChIP-Seq_IB4_Human1.33789573
70* STAT3_23295773_ChIP-Seq_U87_Human1.31791373
71* CBP_20019798_ChIP-Seq_JUKART_Human1.31686298
72* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31686298
73GATA3_21867929_ChIP-Seq_TH1_Mouse1.30357137
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.30206666
75SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.28816707
76OCT4_20526341_ChIP-Seq_ESCs_Human1.28564625
77CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.27899182
78* LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.27190967
79SMRT_27268052_Chip-Seq_Bcells_Human1.26809426
80PHF8_20622853_ChIP-Seq_HELA_Human1.25978273
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.25763847
82GBX2_23144817_ChIP-Seq_PC3_Human1.25071960
83RAD21_21589869_ChIP-Seq_MESCs_Mouse1.24001781
84CJUN_26792858_Chip-Seq_BT549_Human1.22883429
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22835705
86GF1_26923725_Chip-Seq_HPCs_Mouse1.22721255
87TP63_22573176_ChIP-Seq_HFKS_Human1.22513948
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22432030
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22220438
90CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21611513
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21567587
92PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21421275
93NFYA_21822215_ChIP-Seq_K562_Human1.21111500
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21022125
95CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20531724
96TAF2_19829295_ChIP-Seq_ESCs_Human1.20416465
97* RUNX2_22187159_ChIP-Seq_PCA_Human1.20390001
98* GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20093901
99CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19953105
100AR_21572438_ChIP-Seq_LNCaP_Human1.19596491
101BCL6_27268052_Chip-Seq_Bcells_Human1.19465989
102TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19380752
103TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.19163901
104CTCF_27219007_Chip-Seq_Bcells_Human1.18242174
105EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16741031
106TAF15_26573619_Chip-Seq_HEK293_Human1.16608174
107JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16311037
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16277550
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16277550
110* FLI1_21867929_ChIP-Seq_TH2_Mouse1.16210427
111SMAD3_21741376_ChIP-Seq_ESCs_Human1.16174270
112* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.15509006
113KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15378898
114SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15084211
115E2F1_20622854_ChIP-Seq_HELA_Human1.15033249
116SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14944267
117P300_27268052_Chip-Seq_Bcells_Human1.14452585
118SPI1_26923725_Chip-Seq_HPCs_Mouse1.13965169
119PRDM14_20953172_ChIP-Seq_ESCs_Human1.13380360
120SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13083225
121ERG_20517297_ChIP-Seq_VCAP_Human1.12931486
122CEBPB_22108803_ChIP-Seq_LS180_Human1.12058236
123BCOR_27268052_Chip-Seq_Bcells_Human1.10757618
124RUNX1_26923725_Chip-Seq_HPCs_Mouse1.10578185
125* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10267821
126SMC4_20622854_ChIP-Seq_HELA_Human1.08968892
127TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08848665
128OCT1_27270436_Chip-Seq_PROSTATE_Human1.08566096
129P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.08268050
130RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07769162
131MYC_27129775_Chip-Seq_CORNEA_Mouse1.07697792
132* TP63_23658742_ChIP-Seq_EP156T_Human1.07628731
133GATA6_21074721_ChIP-Seq_CACO-2_Human1.07195930
134GATA3_26560356_Chip-Seq_TH1_Human1.06961053
135* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06610999
136PHF8_20622854_ChIP-Seq_HELA_Human1.06407507
137EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.06321780
138CRX_20693478_ChIP-Seq_RETINA_Mouse1.06161701
139PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05944002
140NANOG_18555785_Chip-Seq_ESCs_Mouse1.05230688
141DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04729150
142AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04053208
143ESET_19884257_ChIP-Seq_ESCs_Mouse1.03636244
144GATA1_19941827_ChIP-Seq_MEL86_Mouse1.03531846
145NANOG_19829295_ChIP-Seq_ESCs_Human1.03396310
146YY1_22570637_ChIP-Seq_MALME-3M_Human1.02625973
147NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02617068
148CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01320085
149RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00889931
150JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.00694884
151RARA_24833708_ChIP-Seq_LIVER_Mouse1.00157083
152TET1_21451524_ChIP-Seq_MESCs_Mouse0.99151280
153CTCF_20526341_ChIP-Seq_ESCs_Human0.97111853
154OCT4_18555785_Chip-Seq_ESCs_Mouse0.96601857
155SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96389011
156PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96019647
157SOX11_22085726_ChIP-Seq_ESNs_Mouse0.95539671
158P53_22387025_ChIP-Seq_ESCs_Mouse0.94980406
159TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94462233
160NFYB_21822215_ChIP-Seq_K562_Human0.94239814
161* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92442471
162LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91126942
163FLI1_21867929_ChIP-Seq_CD8_Mouse0.90893633
164MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90874001
165RNF2_27304074_Chip-Seq_NSC_Mouse0.90810539
166ELF1_20517297_ChIP-Seq_JURKAT_Human0.90746539
167NANOG_20526341_ChIP-Seq_ESCs_Human0.90709765
168CMYC_18555785_Chip-Seq_ESCs_Mouse0.90467488
169OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89676873
170EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89549017
171KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.89300255
172TBL1_22424771_ChIP-Seq_293T_Human0.87971625

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.10246362
2MP0001929_abnormal_gametogenesis5.51933667
3MP0008877_abnormal_DNA_methylation3.96317714
4MP0002161_abnormal_fertility/fecundity3.34063627
5MP0002210_abnormal_sex_determination3.32130634
6MP0009697_abnormal_copulation3.19020270
7MP0005670_abnormal_white_adipose3.06051769
8MP0001145_abnormal_male_reproductive2.81314671
9MP0001348_abnormal_lacrimal_gland2.74792074
10MP0002822_catalepsy2.51448323
11MP0000653_abnormal_sex_gland2.42873861
12MP0002653_abnormal_ependyma_morphology2.27789434
13MP0003718_maternal_effect2.17156172
14MP0002132_abnormal_respiratory_system2.16424035
15MP0002138_abnormal_hepatobiliary_system2.08138776
16MP0000678_abnormal_parathyroid_gland2.06655057
17MP0005410_abnormal_fertilization16.6305458
18MP0005451_abnormal_body_composition1.92587046
19MP0005623_abnormal_meninges_morphology1.54365844
20MP0003646_muscle_fatigue1.46327711
21MP0002160_abnormal_reproductive_system1.45193578
22MP0002282_abnormal_trachea_morphology1.31284556
23MP0004233_abnormal_muscle_weight1.29799747
24MP0005275_abnormal_skin_tensile1.23218856
25MP0001765_abnormal_ion_homeostasis1.20946307
26MP0003283_abnormal_digestive_organ1.17657726
27MP0002127_abnormal_cardiovascular_syste1.17202939
28MP0005395_other_phenotype1.15426329
29MP0002254_reproductive_system_inflammat1.13569724
30MP0005310_abnormal_salivary_gland1.13097654
31MP0001486_abnormal_startle_reflex1.07144792
32MP0001270_distended_abdomen1.04139972
33MP0001485_abnormal_pinna_reflex1.03594074
34MP0000003_abnormal_adipose_tissue1.01517312
35MP0005248_abnormal_Harderian_gland0.98426951
36MP0003195_calcinosis0.96510878
37MP0003252_abnormal_bile_duct0.93880028
38MP0001905_abnormal_dopamine_level0.93366659
39MP0001984_abnormal_olfaction0.92772092
40MP0002249_abnormal_larynx_morphology0.91164964
41MP0005647_abnormal_sex_gland0.89538844
42MP0008995_early_reproductive_senescence0.89264340
43MP0010368_abnormal_lymphatic_system0.87945898
44MP0004084_abnormal_cardiac_muscle0.86708207
45MP0005379_endocrine/exocrine_gland_phen0.86699951
46MP0001501_abnormal_sleep_pattern0.82463384
47MP0008058_abnormal_DNA_repair0.82236455
48MP0010386_abnormal_urinary_bladder0.81978133
49MP0000026_abnormal_inner_ear0.79586840
50MP0001963_abnormal_hearing_physiology0.77853695
51MP0009046_muscle_twitch0.77660213
52MP0004085_abnormal_heartbeat0.76240655
53MP0005377_hearing/vestibular/ear_phenot0.75585897
54MP0003878_abnormal_ear_physiology0.75585897
55MP0008775_abnormal_heart_ventricle0.74960689
56MP0002234_abnormal_pharynx_morphology0.74830192
57MP0003115_abnormal_respiratory_system0.74323212
58MP0005389_reproductive_system_phenotype0.71470326
59MP0000013_abnormal_adipose_tissue0.70036191
60MP0001879_abnormal_lymphatic_vessel0.69929919
61MP0005636_abnormal_mineral_homeostasis0.67646067
62MP0002735_abnormal_chemical_nociception0.67290367
63MP0005666_abnormal_adipose_tissue0.64923139
64MP0000230_abnormal_systemic_arterial0.64502042
65MP0003011_delayed_dark_adaptation0.63685832
66MP0004510_myositis0.63394165
67MP0005171_absent_coat_pigmentation0.60452982
68MP0009780_abnormal_chondrocyte_physiolo0.58163812
69MP0005266_abnormal_metabolism0.56186078
70MP0000681_abnormal_thyroid_gland0.56140290
71MP0001666_abnormal_nutrient_absorption0.55970030
72MP0003329_amyloid_beta_deposits0.55883122
73MP0000569_abnormal_digit_pigmentation0.54849780
74MP0005376_homeostasis/metabolism_phenot0.54428570
75MP0001764_abnormal_homeostasis0.54294667
76MP0002067_abnormal_sensory_capabilities0.53661016
77MP0004036_abnormal_muscle_relaxation0.52754317
78MP0001324_abnormal_eye_pigmentation0.52440999
79MP0000955_abnormal_spinal_cord0.52339118
80MP0000470_abnormal_stomach_morphology0.50682330
81MP0003091_abnormal_cell_migration0.49719275
82MP0002168_other_aberrant_phenotype0.49712453
83MP0002557_abnormal_social/conspecific_i0.49330878
84MP0010329_abnormal_lipoprotein_level0.49150257
85MP0000358_abnormal_cell_content/0.48739758
86MP0005085_abnormal_gallbladder_physiolo0.48532847
87MP0002933_joint_inflammation0.48393331
88MP0002108_abnormal_muscle_morphology0.47919267
89MP0003699_abnormal_female_reproductive0.47546246
90MP0003183_abnormal_peptide_metabolism0.47357527
91MP0008789_abnormal_olfactory_epithelium0.45573354
92MP0009278_abnormal_bone_marrow0.45491881
93MP0001293_anophthalmia0.45137614
94MP0002736_abnormal_nociception_after0.44761599
95MP0002269_muscular_atrophy0.44677814
96MP0005397_hematopoietic_system_phenotyp0.44215427
97MP0001545_abnormal_hematopoietic_system0.44215427
98MP0010094_abnormal_chromosome_stability0.43472860
99MP0002928_abnormal_bile_duct0.41537141
100MP0000249_abnormal_blood_vessel0.41392478
101MP0002166_altered_tumor_susceptibility0.41080056
102MP0000427_abnormal_hair_cycle0.40911754
103MP0005253_abnormal_eye_physiology0.40171538
104MP0009115_abnormal_fat_cell0.40012287
105MP0002136_abnormal_kidney_physiology0.39628437
106MP0000534_abnormal_ureter_morphology0.38999288
107MP0003950_abnormal_plasma_membrane0.38273572
108MP0002115_abnormal_skeleton_extremities0.37802792
109MP0005535_abnormal_body_temperature0.36661755
110MP0005551_abnormal_eye_electrophysiolog0.36416917
111MP0006036_abnormal_mitochondrial_physio0.33153493
112MP0002971_abnormal_brown_adipose0.32819491
113MP0005391_vision/eye_phenotype0.30529370
114MP0004133_heterotaxia0.30179091
115MP0003633_abnormal_nervous_system0.30083788
116MP0003879_abnormal_hair_cell0.29553006
117MP0003942_abnormal_urinary_system0.29395533
118MP0000604_amyloidosis0.28544274
119MP0002139_abnormal_hepatobiliary_system0.28027860
120MP0003111_abnormal_nucleus_morphology0.27700503
121MP0002295_abnormal_pulmonary_circulatio0.27027854
122MP0004811_abnormal_neuron_physiology0.26897166
123MP0003786_premature_aging0.25502283
124MP0001119_abnormal_female_reproductive0.25249149
125MP0004019_abnormal_vitamin_homeostasis0.24619470
126MP0001968_abnormal_touch/_nociception0.23612489
127MP0005375_adipose_tissue_phenotype0.23436225
128MP0003948_abnormal_gas_homeostasis0.23069629
129MP0003631_nervous_system_phenotype0.22792453
130MP0001730_embryonic_growth_arrest0.22620428
131MP0008961_abnormal_basal_metabolism0.22409813
132MP0003861_abnormal_nervous_system0.22285552
133MP0002169_no_abnormal_phenotype0.21752082
134MP0004742_abnormal_vestibular_system0.21570361
135MP0002873_normal_phenotype0.21509151
136MP0000751_myopathy0.21326616
137MP0002152_abnormal_brain_morphology0.20403846
138MP0001727_abnormal_embryo_implantation0.20053961
139MP0001849_ear_inflammation0.19916097
140MP0004043_abnormal_pH_regulation0.18657217
141MP0004145_abnormal_muscle_electrophysio0.17605382
142MP0004270_analgesia0.17128095
143MP0002092_abnormal_eye_morphology0.16125969
144MP0010307_abnormal_tumor_latency0.15989047
145MP0006035_abnormal_mitochondrial_morpho0.15868723
146MP0003787_abnormal_imprinting0.15773084
147MP0005365_abnormal_bile_salt0.15151530
148MP0008875_abnormal_xenobiotic_pharmacok0.14826774
149MP0002102_abnormal_ear_morphology0.14217463
150MP0008007_abnormal_cellular_replicative0.14152400
151MP0000462_abnormal_digestive_system0.14074906
152MP0002118_abnormal_lipid_homeostasis0.14015807
153MP0002693_abnormal_pancreas_physiology0.13805654
154MP0003045_fibrosis0.13628061
155MP0005319_abnormal_enzyme/_coenzyme0.13555907
156MP0001440_abnormal_grooming_behavior0.13530418
157MP0008569_lethality_at_weaning0.13483664
158MP0000001_mammalian_phenotype0.13240562
159MP0002229_neurodegeneration0.13122587
160MP0003959_abnormal_lean_body0.13101166
161MP0009672_abnormal_birth_weight0.12351044

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.31740953
2Abnormal respiratory motile cilium morphology (HP:0005938)9.31740953
3Abnormal respiratory motile cilium physiology (HP:0012261)9.29790923
4Severe visual impairment (HP:0001141)7.82653683
5Abnormal ciliary motility (HP:0012262)7.40318311
6Rhinitis (HP:0012384)7.36770676
7Chronic bronchitis (HP:0004469)7.24911166
8Infertility (HP:0000789)7.06404745
9Nasal polyposis (HP:0100582)6.39125570
10Abnormality of the nasal mucosa (HP:0000433)5.26122323
11Male infertility (HP:0003251)5.10046316
12Hyperkalemia (HP:0002153)4.84609584
13Chronic hepatic failure (HP:0100626)4.71336759
14Bronchitis (HP:0012387)4.66360663
15Bronchiectasis (HP:0002110)4.41379078
16Bony spicule pigmentary retinopathy (HP:0007737)4.35104350
17Hypoplasia of the thymus (HP:0000778)4.29299484
18Attenuation of retinal blood vessels (HP:0007843)4.24471669
19Resting tremor (HP:0002322)4.22936400
20Nephronophthisis (HP:0000090)4.17614122
21Abnormality of macular pigmentation (HP:0008002)4.13392694
22Cone-rod dystrophy (HP:0000548)4.04710353
23Menstrual irregularities (HP:0000858)3.96269997
24Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.93513820
25Abnormal spermatogenesis (HP:0008669)3.75101393
26Abnormal rod and cone electroretinograms (HP:0008323)3.71344826
27Hypoplastic ischia (HP:0003175)3.58714123
28Recurrent sinusitis (HP:0011108)3.36588370
29Recurrent otitis media (HP:0000403)3.34207609
30Aplasia/Hypoplasia of the earlobes (HP:0009906)3.30216798
31Hypoalphalipoproteinemia (HP:0003233)3.18331548
32Abnormality of the renal medulla (HP:0100957)3.16494929
33Abnormality of the ischium (HP:0003174)3.08658783
34Insulin-resistant diabetes mellitus (HP:0000831)3.07270312
35Facial shape deformation (HP:0011334)3.00487828
36Potter facies (HP:0002009)3.00487828
37Tubulointerstitial nephritis (HP:0001970)2.94134435
38Recurrent bronchitis (HP:0002837)2.93993662
39Unilateral renal agenesis (HP:0000122)2.76797341
40Enlarged epiphyses (HP:0010580)2.74084814
41Impulsivity (HP:0100710)2.73778759
42Progressive sensorineural hearing impairment (HP:0000408)2.70537414
43Abnormality of potassium homeostasis (HP:0011042)2.61622095
44Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.60556344
45Postural instability (HP:0002172)2.56836040
46Tubular atrophy (HP:0000092)2.55405635
47Polyuria (HP:0000103)2.52897326
48Abnormal gallbladder physiology (HP:0012438)2.52087443
49Cholecystitis (HP:0001082)2.52087443
50Abnormality of midbrain morphology (HP:0002418)2.49177539
51Molar tooth sign on MRI (HP:0002419)2.49177539
52Tubulointerstitial abnormality (HP:0001969)2.45098770
53Gonadotropin excess (HP:0000837)2.38227393
54Progressive cerebellar ataxia (HP:0002073)2.37363566
55Amelogenesis imperfecta (HP:0000705)2.32305562
56Progressive hearing impairment (HP:0001730)2.27533494
57Azoospermia (HP:0000027)2.25210718
58Tetany (HP:0001281)2.23234428
59Renal Fanconi syndrome (HP:0001994)2.22546144
60Dyschromatopsia (HP:0007641)2.20843475
61Medial flaring of the eyebrow (HP:0010747)2.18982136
62Recurrent corneal erosions (HP:0000495)2.18446815
63Epiphyseal dysplasia (HP:0002656)2.16928609
64Abnormality of lateral ventricle (HP:0030047)2.10415970
65Abnormality of dental color (HP:0011073)2.07749293
66Hypolipoproteinemia (HP:0010981)2.03362918
67Spastic tetraparesis (HP:0001285)2.01433415
68Absent/shortened dynein arms (HP:0200106)13.6840722
69Dynein arm defect of respiratory motile cilia (HP:0012255)13.6840722
70Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9992342
71Choroideremia (HP:0001139)1.99858110
72Decreased central vision (HP:0007663)1.96559352
73Tubulointerstitial fibrosis (HP:0005576)1.93049443
74Macular degeneration (HP:0000608)1.86887140
75Ventricular tachycardia (HP:0004756)1.86388597
76Photophobia (HP:0000613)1.85500032
77Genetic anticipation (HP:0003743)1.81751243
78Aplasia/Hypoplasia of the thymus (HP:0010515)1.81144431
79Type II diabetes mellitus (HP:0005978)1.81040373
80Stage 5 chronic kidney disease (HP:0003774)1.78021051
81Heterotopia (HP:0002282)1.77631776
82Focal segmental glomerulosclerosis (HP:0000097)1.77546883
83Postaxial foot polydactyly (HP:0001830)1.76624255
84Glomerulosclerosis (HP:0000096)1.76514042
85Hemorrhage of the eye (HP:0011885)1.74609279
86Generalized aminoaciduria (HP:0002909)1.74141941
87Abnormal biliary tract physiology (HP:0012439)1.73560646
88Bile duct proliferation (HP:0001408)1.73560646
89Abnormal drinking behavior (HP:0030082)1.72510891
90Polydipsia (HP:0001959)1.72510891
91Acute hepatic failure (HP:0006554)1.71777525
92Abnormality of the costochondral junction (HP:0000919)1.71617078
93Portal hypertension (HP:0001409)1.71227181
94Anterior segment dysgenesis (HP:0007700)1.70762988
95Hypophosphatemic rickets (HP:0004912)1.70499075
96Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.70372337
97Slow saccadic eye movements (HP:0000514)1.70096949
98Bulbous nose (HP:0000414)1.69533349
99Hyponatremia (HP:0002902)1.69444515
100Abnormality of the parathyroid morphology (HP:0011766)1.67724871
101Congenital hepatic fibrosis (HP:0002612)1.66951316
102Atrophic scars (HP:0001075)1.66831469
103Insulin resistance (HP:0000855)1.65775649
104Abnormality of the renal cortex (HP:0011035)1.64269447
105Glycosuria (HP:0003076)1.63882242
106Abnormality of urine glucose concentration (HP:0011016)1.63882242
107Abnormality of the pubic bones (HP:0003172)1.63168525
108Abnormality of renal excretion (HP:0011036)1.62180998
109Asymmetric septal hypertrophy (HP:0001670)1.61774167
110Bell-shaped thorax (HP:0001591)1.61294997
111Intrahepatic cholestasis (HP:0001406)1.61257311
112Flattened epiphyses (HP:0003071)1.61034601
113Congenital sensorineural hearing impairment (HP:0008527)1.59832121
114Neurofibrillary tangles (HP:0002185)1.58299462
115Short ribs (HP:0000773)1.58292568
116Hypoplasia of the capital femoral epiphysis (HP:0003090)1.57608329
117Decreased electroretinogram (ERG) amplitude (HP:0000654)1.53049668
118Oculomotor apraxia (HP:0000657)1.49661540
119Fibular hypoplasia (HP:0003038)1.49616818
120Abnormality of the dental root (HP:0006486)1.47464273
121Taurodontia (HP:0000679)1.47464273
122Abnormality of permanent molar morphology (HP:0011071)1.47464273
123Congenital malformation of the right heart (HP:0011723)1.46262000
124Double outlet right ventricle (HP:0001719)1.46262000
125Abnormality of dentin (HP:0010299)1.46017630
126Abnormality of the lower motor neuron (HP:0002366)1.45547465
127Bundle branch block (HP:0011710)1.43815331
128Cystic liver disease (HP:0006706)1.39011768
129Abnormality of the dental pulp (HP:0006479)1.37185831
130Renal dysplasia (HP:0000110)1.36963899
131Abnormality of molar (HP:0011077)1.36118597
132Abnormality of molar morphology (HP:0011070)1.36118597
133Deformed sella turcica (HP:0002681)1.35994762
134Abnormal urine output (HP:0012590)1.35348982
135Postaxial hand polydactyly (HP:0001162)1.35121463
136Aplasia/Hypoplasia of the lens (HP:0008063)1.34254303
137Cerebral inclusion bodies (HP:0100314)1.31283256
138Hemiparesis (HP:0001269)1.30795730
139Constricted visual fields (HP:0001133)1.29779759
140Absent frontal sinuses (HP:0002688)1.27563511
141Facial cleft (HP:0002006)1.27308008
142Exercise-induced myalgia (HP:0003738)1.27295399
143Hypercholesterolemia (HP:0003124)1.26117414
144Amyotrophic lateral sclerosis (HP:0007354)1.25656594
145Absent epiphyses (HP:0010577)1.24719243
146Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.24719243
147Myoglobinuria (HP:0002913)1.22986423
148Chronic sinusitis (HP:0011109)1.22362625
149Broad distal phalanx of finger (HP:0009836)1.21744796
150Easy fatigability (HP:0003388)1.21681203
151Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.19367394
152Truncal obesity (HP:0001956)1.18943332
153Pancreatic fibrosis (HP:0100732)1.18197825
154J-shaped sella turcica (HP:0002680)1.18130619
155Nephropathy (HP:0000112)1.16128830
156Sensory axonal neuropathy (HP:0003390)1.15454692
157Short thorax (HP:0010306)1.15075450
158Microglossia (HP:0000171)1.14402417
159Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.14386226
160Loss of speech (HP:0002371)1.13353112
161Cerebellar dysplasia (HP:0007033)1.11316162
162Short femoral neck (HP:0100864)1.10052320
163Fatigable weakness (HP:0003473)1.09910695

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.17715070
2PDK48.17715070
3TESK16.22986619
4PRKD35.34866363
5PDK25.28890292
6ICK4.52387386
7DDR24.04285434
8MAP4K23.52328600
9BRD43.30524252
10PLK23.06868906
11PIK3CG2.80610773
12INSRR2.79086931
13LATS12.39188906
14PTK2B2.23874065
15WNK42.13918586
16PNCK2.13840560
17TAF12.07472172
18MST1R2.06636759
19STK391.99448715
20STK381.86966129
21DYRK1B1.67267045
22BMPR21.61896795
23FRK1.58079331
24NEK21.44906589
25RPS6KA41.35328655
26CDK31.30383986
27MYLK1.29796573
28MAP3K91.25125453
29PDK11.19315315
30NUAK11.13111852
31MAP3K21.09645395
32CDK71.01805961
33AKT30.99727020
34MAP3K40.96034624
35MAPK150.90907411
36TYRO30.88573959
37DYRK30.88322341
38WNK10.84200552
39ERBB30.83145382
40KSR20.79207361
41PDPK10.74056349
42MAP2K70.72205467
43PIK3CA0.72036810
44PRKAA20.70294695
45CAMK10.68336493
46IRAK10.68011677
47CAMK1G0.67589840
48RIPK40.67385641
49FLT30.67358002
50MET0.67140772
51PASK0.66061215
52TRPM70.65037210
53MAP3K120.63826149
54MAPK110.63202035
55EEF2K0.61535402
56MAP2K60.61041002
57CCNB10.60648945
58SGK2230.59449004
59SGK4940.59449004
60STK30.59171923
61TESK20.57371576
62KIT0.57301454
63TTK0.57188039
64CHEK20.56502356
65JAK30.56216181
66RPS6KA20.53006947
67CAMK1D0.52515814
68LMTK20.48188975
69PINK10.48084609
70ROCK10.47031546
71PRKCE0.46875316
72IKBKB0.44666987
73IRAK40.44533960
74PAK10.42802899
75STK38L0.41100445
76SRPK10.38913347
77NTRK20.38490324
78CHEK10.37630839
79SGK20.37162977
80RPS6KC10.36491658
81RPS6KL10.36491658
82IRAK20.35282830
83MAPK10.34932147
84BCKDK0.34667176
85MUSK0.34470078
86PRKCG0.34310954
87UHMK10.33670739
88PAK20.33129738
89MAP3K70.33030490
90RPS6KA60.31948426
91SIK20.31856255
92OBSCN0.31260826
93MAP3K100.30621912
94CHUK0.30589395
95NEK90.30385850
96MTOR0.28945502
97GRK60.28758753
98CAMKK10.28490947
99ITK0.27533772
100TAOK30.27106753
101ATM0.27058526
102CDK190.26733067
103NEK60.26553907
104MAP3K80.26403925
105MARK20.26355806
106PAK40.24520563
107PRKCH0.23879007
108MAPKAPK50.23206089
109ATR0.22475631
110MAP2K20.20893288
111WEE10.19891945
112TRIB30.19054445
113PRKCZ0.18475714
114PRKAA10.18421823
115CDK150.14330995
116PRKCQ0.14194065
117RPS6KB10.13435447
118PLK40.13262428
119BRSK20.11787178
120CDK180.11645091
121CDK60.11218501
122CDC70.11134241
123PLK10.10633306
124CDK11A0.10535030
125PRKG20.09541876
126GSK3B0.07232816
127CDK140.06623825
128BRSK10.06367593
129RPS6KA10.05879769
130CSNK2A10.05694045
131CSNK1D0.05277791
132MARK30.04853307
133CDK40.03991081
134STK100.03988457
135PRKG10.03208821
136CDK10.02809385
137CDK20.02677701
138BRAF0.02581705
139PRKACG0.02337400
140CAMK2A0.02312836
141CSNK2A20.01707548
142PRKCD0.01689984
143PRKCB0.01406827
144MAPK80.01268841
145PIM10.01168928
146STK110.01158775
147CSF1R0.01145442
148PKN10.00844260
149WNK30.00554554
150PRKCA0.00021955
151PDGFRB-0.0296974
152ZAP70-0.0280742
153EPHB1-0.0257885
154PRKDC-0.0228645
155RPS6KA3-0.0219430
156PRKACB-0.0190134
157EGFR-0.0175108
158CDK12-0.0157266
159PAK6-0.0138858
160MAP3K1-0.0135646
161CLK1-0.0008824

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.94262217
2Fatty acid biosynthesis_Homo sapiens_hsa000614.77449870
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.63245428
4Vitamin B6 metabolism_Homo sapiens_hsa007503.42306352
5Pyruvate metabolism_Homo sapiens_hsa006203.41100372
6Butanoate metabolism_Homo sapiens_hsa006503.33637391
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.09414174
8Linoleic acid metabolism_Homo sapiens_hsa005912.98540770
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.92667346
10Olfactory transduction_Homo sapiens_hsa047402.73985844
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.61301999
12Propanoate metabolism_Homo sapiens_hsa006402.60491517
13Glucagon signaling pathway_Homo sapiens_hsa049222.59715326
14Carbohydrate digestion and absorption_Homo sapiens_hsa049732.52902399
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.11616105
16Basal transcription factors_Homo sapiens_hsa030222.07043267
17Glycerolipid metabolism_Homo sapiens_hsa005611.99925540
18PPAR signaling pathway_Homo sapiens_hsa033201.97018160
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.89239790
20Selenocompound metabolism_Homo sapiens_hsa004501.87259175
21Fructose and mannose metabolism_Homo sapiens_hsa000511.72465285
22Glycerophospholipid metabolism_Homo sapiens_hsa005641.71604059
23Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.68447973
24Oocyte meiosis_Homo sapiens_hsa041141.61183580
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.60598424
26Mineral absorption_Homo sapiens_hsa049781.59941399
27Dorso-ventral axis formation_Homo sapiens_hsa043201.56890285
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.56736290
29Pentose phosphate pathway_Homo sapiens_hsa000301.53044442
30Fatty acid degradation_Homo sapiens_hsa000711.48826082
31Fatty acid metabolism_Homo sapiens_hsa012121.48121093
32Fat digestion and absorption_Homo sapiens_hsa049751.45990543
33Amphetamine addiction_Homo sapiens_hsa050311.45357407
34Carbon metabolism_Homo sapiens_hsa012001.37408573
35Ether lipid metabolism_Homo sapiens_hsa005651.36711515
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.36559984
37Phototransduction_Homo sapiens_hsa047441.34967132
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.34841862
39Cardiac muscle contraction_Homo sapiens_hsa042601.28142718
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25601070
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25390921
42Retinol metabolism_Homo sapiens_hsa008301.22451049
43Antigen processing and presentation_Homo sapiens_hsa046121.15957612
44Fanconi anemia pathway_Homo sapiens_hsa034601.15254406
45Circadian rhythm_Homo sapiens_hsa047101.14174193
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.12353984
47Renin secretion_Homo sapiens_hsa049241.10561421
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.09098409
49Type I diabetes mellitus_Homo sapiens_hsa049401.08815411
50Peroxisome_Homo sapiens_hsa041461.08619634
51Phenylalanine metabolism_Homo sapiens_hsa003601.07404718
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00923816
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00141445
54mRNA surveillance pathway_Homo sapiens_hsa030150.97595463
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95271232
56Hedgehog signaling pathway_Homo sapiens_hsa043400.93128624
57Huntingtons disease_Homo sapiens_hsa050160.92185680
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.89739120
59Glutathione metabolism_Homo sapiens_hsa004800.89448499
60Biosynthesis of amino acids_Homo sapiens_hsa012300.88787211
61Insulin secretion_Homo sapiens_hsa049110.88158041
62Collecting duct acid secretion_Homo sapiens_hsa049660.87632899
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.87590105
64Bile secretion_Homo sapiens_hsa049760.82951006
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82475099
66Regulation of autophagy_Homo sapiens_hsa041400.82071566
67Arachidonic acid metabolism_Homo sapiens_hsa005900.80490938
68Chemical carcinogenesis_Homo sapiens_hsa052040.80490386
69Thyroid hormone synthesis_Homo sapiens_hsa049180.79830384
70Caffeine metabolism_Homo sapiens_hsa002320.78765948
71RNA transport_Homo sapiens_hsa030130.77771034
72Estrogen signaling pathway_Homo sapiens_hsa049150.76926391
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71281206
74Long-term potentiation_Homo sapiens_hsa047200.70602958
75Sphingolipid metabolism_Homo sapiens_hsa006000.69492486
76Influenza A_Homo sapiens_hsa051640.67202609
77Autoimmune thyroid disease_Homo sapiens_hsa053200.66450389
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.65481299
79Legionellosis_Homo sapiens_hsa051340.64182989
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.62811720
81Allograft rejection_Homo sapiens_hsa053300.62612841
82Renin-angiotensin system_Homo sapiens_hsa046140.60342772
83Graft-versus-host disease_Homo sapiens_hsa053320.59883240
84Herpes simplex infection_Homo sapiens_hsa051680.59538047
85Salivary secretion_Homo sapiens_hsa049700.58831380
86Pancreatic secretion_Homo sapiens_hsa049720.57979502
87* Purine metabolism_Homo sapiens_hsa002300.57938593
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57643604
89Protein digestion and absorption_Homo sapiens_hsa049740.57401086
90T cell receptor signaling pathway_Homo sapiens_hsa046600.56163201
91ABC transporters_Homo sapiens_hsa020100.54703114
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54566496
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53644658
94Calcium signaling pathway_Homo sapiens_hsa040200.53172473
95Prolactin signaling pathway_Homo sapiens_hsa049170.52261214
96Viral carcinogenesis_Homo sapiens_hsa052030.48477669
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48059538
98Gastric acid secretion_Homo sapiens_hsa049710.47359062
99AMPK signaling pathway_Homo sapiens_hsa041520.46207276
100Endocytosis_Homo sapiens_hsa041440.46205778
101Synaptic vesicle cycle_Homo sapiens_hsa047210.45097381
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.44564909
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.44365170
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44131822
105Nicotine addiction_Homo sapiens_hsa050330.44122132
106Acute myeloid leukemia_Homo sapiens_hsa052210.43736244
107Non-homologous end-joining_Homo sapiens_hsa034500.43615117
108Measles_Homo sapiens_hsa051620.42678769
109ECM-receptor interaction_Homo sapiens_hsa045120.42657906
110Morphine addiction_Homo sapiens_hsa050320.42563556
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41984325
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41614429
113Inositol phosphate metabolism_Homo sapiens_hsa005620.41263685
114Tyrosine metabolism_Homo sapiens_hsa003500.41025921
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40470334
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39671973
117Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39397600
118Lysine degradation_Homo sapiens_hsa003100.39156362
119Platelet activation_Homo sapiens_hsa046110.38530971
120Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38486873
121Sulfur metabolism_Homo sapiens_hsa009200.38332473
122Taste transduction_Homo sapiens_hsa047420.36219396
123cAMP signaling pathway_Homo sapiens_hsa040240.35687783
124VEGF signaling pathway_Homo sapiens_hsa043700.35625977
125Systemic lupus erythematosus_Homo sapiens_hsa053220.34071266
126Arginine and proline metabolism_Homo sapiens_hsa003300.33797509
127Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.32794656
128Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31949298
129Viral myocarditis_Homo sapiens_hsa054160.30738884
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30628219
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29851819
132* Metabolic pathways_Homo sapiens_hsa011000.29709866
133Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29310130
134Circadian entrainment_Homo sapiens_hsa047130.29175306
135Tight junction_Homo sapiens_hsa045300.28925056
136GABAergic synapse_Homo sapiens_hsa047270.28862102
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27658363
138Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26500559
139Cocaine addiction_Homo sapiens_hsa050300.26337644
140Alcoholism_Homo sapiens_hsa050340.15854247
141Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.15479206
142B cell receptor signaling pathway_Homo sapiens_hsa046620.11857326
143HIF-1 signaling pathway_Homo sapiens_hsa040660.11724500
144Type II diabetes mellitus_Homo sapiens_hsa049300.09818862
145Wnt signaling pathway_Homo sapiens_hsa043100.09653977
146Basal cell carcinoma_Homo sapiens_hsa052170.09354126
147Insulin resistance_Homo sapiens_hsa049310.06474343
148Salmonella infection_Homo sapiens_hsa051320.04942602
149Glutamatergic synapse_Homo sapiens_hsa047240.04621634
150Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.04489850

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