NT5C2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)5.15467877
2positive regulation of gamma-delta T cell activation (GO:0046645)4.90795491
3dosage compensation (GO:0007549)4.79963147
4COPI coating of Golgi vesicle (GO:0048205)4.77377636
5Golgi transport vesicle coating (GO:0048200)4.77377636
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.62861650
7negative regulation of cell killing (GO:0031342)4.62861650
8negative regulation of cell size (GO:0045792)4.33387120
9neutrophil activation involved in immune response (GO:0002283)4.33116885
10modulation by symbiont of host defense response (GO:0052031)4.29151919
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.29151919
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.29151919
13positive regulation by organism of defense response of other organism involved in symbiotic interact4.29151919
14modulation by symbiont of host immune response (GO:0052553)4.29151919
15positive regulation by symbiont of host defense response (GO:0052509)4.29151919
16folic acid-containing compound biosynthetic process (GO:0009396)4.23950587
17detection of other organism (GO:0098543)4.13151455
18peptidyl-lysine dimethylation (GO:0018027)4.12955066
19cellular extravasation (GO:0045123)3.87438023
20detection of molecule of bacterial origin (GO:0032490)3.82613397
21positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.82228108
22negative regulation of interleukin-12 production (GO:0032695)3.75955169
23negative regulation of histone methylation (GO:0031061)3.72812700
24detection of bacterium (GO:0016045)3.70922359
25positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.69252878
26germinal center formation (GO:0002467)3.68154016
27macrophage activation involved in immune response (GO:0002281)3.67165433
28viral protein processing (GO:0019082)3.66957987
29negative regulation of microtubule polymerization (GO:0031115)3.64914503
30neutrophil activation (GO:0042119)3.61553159
31detection of external biotic stimulus (GO:0098581)3.59366696
32antigen processing and presentation via MHC class Ib (GO:0002475)3.55087786
33ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.53310724
34negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.53148921
35DNA unwinding involved in DNA replication (GO:0006268)3.51876407
36growth hormone secretion (GO:0030252)3.50715067
37regulation of necroptotic process (GO:0060544)3.45549934
38immunoglobulin mediated immune response (GO:0016064)3.43417482
39DNA deamination (GO:0045006)3.40741622
40positive regulation of B cell differentiation (GO:0045579)3.38967498
41response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.38832642
42response to host immune response (GO:0052572)3.38832642
43negative regulation of gene expression, epigenetic (GO:0045814)3.37545093
44neutrophil mediated immunity (GO:0002446)3.36816323
45regulation of gamma-delta T cell activation (GO:0046643)3.35450042
46granulocyte activation (GO:0036230)3.34990911
47regulation of B cell receptor signaling pathway (GO:0050855)3.34661217
48regulation of interferon-beta biosynthetic process (GO:0045357)3.32439854
49negative regulation of lymphocyte mediated immunity (GO:0002707)3.32244228
50response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.30368213
51response to host (GO:0075136)3.30368213
52response to host defenses (GO:0052200)3.30368213
53respiratory burst (GO:0045730)3.23867131
54regulation of histone H3-K9 methylation (GO:0051570)3.23140058
55virion assembly (GO:0019068)3.20227469
56nucleosome disassembly (GO:0006337)3.17971398
57protein-DNA complex disassembly (GO:0032986)3.17971398
58response to pheromone (GO:0019236)3.17830101
59synaptic vesicle maturation (GO:0016188)3.15120822
60B cell receptor signaling pathway (GO:0050853)3.14449838
61negative regulation of RNA splicing (GO:0033119)3.11065507
62lipopolysaccharide-mediated signaling pathway (GO:0031663)3.09126698
63antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.08425846
64antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.08425846
65detection of biotic stimulus (GO:0009595)3.07543215
66regulation of leukocyte degranulation (GO:0043300)3.06971174
673-UTR-mediated mRNA stabilization (GO:0070935)3.06227705
68regulation of mast cell degranulation (GO:0043304)3.06042478
69regulation of NFAT protein import into nucleus (GO:0051532)2.97981829
70regulation of myeloid leukocyte mediated immunity (GO:0002886)2.97825249
71regulation of translational fidelity (GO:0006450)2.97387896
72regulation of translational termination (GO:0006449)2.96974823
73positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.96187184
74DNA strand elongation (GO:0022616)2.96168697
75negative regulation of leukocyte mediated immunity (GO:0002704)2.95496482
76DNA strand elongation involved in DNA replication (GO:0006271)2.94478299
77tricarboxylic acid metabolic process (GO:0072350)2.93736538
78regulation of gamma-delta T cell differentiation (GO:0045586)2.93151900
79regulation of protein heterodimerization activity (GO:0043497)2.92940138
80negative regulation of T cell mediated immunity (GO:0002710)2.91590644
81response to muramyl dipeptide (GO:0032495)2.91487130
82protein localization to endosome (GO:0036010)2.90497433
83ncRNA 3-end processing (GO:0043628)2.89014803
84positive regulation of interferon-alpha production (GO:0032727)2.87214786
85regulation of mast cell activation involved in immune response (GO:0033006)2.86446198
86positive regulation of interleukin-17 production (GO:0032740)2.85874369
87sodium ion export (GO:0071436)2.85606518
88glial cell proliferation (GO:0014009)2.84886955
89negative regulation of necroptotic process (GO:0060546)2.84330952
90translesion synthesis (GO:0019985)2.83876902
91phospholipid translocation (GO:0045332)2.82216246
92lipid translocation (GO:0034204)2.82216246
93macrophage activation (GO:0042116)2.81998822
94antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.81887690
95myeloid cell activation involved in immune response (GO:0002275)2.81707844
96microglial cell activation (GO:0001774)2.81570335
97response to interleukin-15 (GO:0070672)2.81395847
98protein maturation by protein folding (GO:0022417)2.81180715
99myeloid leukocyte mediated immunity (GO:0002444)2.79858348
100histone H4-K12 acetylation (GO:0043983)2.79558471
101negative regulation of glycoprotein biosynthetic process (GO:0010561)2.77988016
102regulation of interleukin-17 production (GO:0032660)2.77926615
103hypotonic response (GO:0006971)2.76475378
104leukocyte migration involved in inflammatory response (GO:0002523)2.75885818
105histone H4-K8 acetylation (GO:0043982)2.75690575
106histone H4-K5 acetylation (GO:0043981)2.75690575
107B cell homeostasis (GO:0001782)2.74576620
108pteridine-containing compound biosynthetic process (GO:0042559)2.74382072
109peptidyl-arginine omega-N-methylation (GO:0035247)2.73552103
110histone H4 deacetylation (GO:0070933)2.72781653
111regulation of interferon-alpha production (GO:0032647)2.72704176
112locomotory exploration behavior (GO:0035641)2.71385707
113regulation of B cell differentiation (GO:0045577)2.70900884
114type I interferon signaling pathway (GO:0060337)2.70643893
115cellular response to type I interferon (GO:0071357)2.70643893
116spliceosomal tri-snRNP complex assembly (GO:0000244)2.68554126
117B cell mediated immunity (GO:0019724)2.67182772
118leukocyte aggregation (GO:0070486)2.66286316
119positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.65604128
120response to type I interferon (GO:0034340)2.65025807
121cell communication by electrical coupling (GO:0010644)2.63542312
122regulation of regulated secretory pathway (GO:1903305)2.63495577
123deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.62814066
124interferon-gamma-mediated signaling pathway (GO:0060333)2.61913067
125histone lysine demethylation (GO:0070076)2.61514121
126DNA replication initiation (GO:0006270)2.61180783
127Arp2/3 complex-mediated actin nucleation (GO:0034314)2.60920494
128regulation of early endosome to late endosome transport (GO:2000641)2.60844882
129negative regulation of erythrocyte differentiation (GO:0045647)2.60584827
130retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.60160065
131histone H4-K16 acetylation (GO:0043984)2.59796110
132negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.59686051
133multi-organism intracellular transport (GO:1902583)2.59466656
134transport of virus (GO:0046794)2.59466656
135intracellular transport of virus (GO:0075733)2.59466656
136multi-organism transport (GO:0044766)2.59466656
137multi-organism localization (GO:1902579)2.59466656
138pentose-phosphate shunt (GO:0006098)2.59436182
139regulation of synapse structural plasticity (GO:0051823)2.58626367
140regulation of mast cell activation (GO:0033003)2.57987027
141regulation of T-helper 2 cell differentiation (GO:0045628)2.57411742
142positive regulation of nuclease activity (GO:0032075)2.56800720
143regulation of erythrocyte differentiation (GO:0045646)2.54832825
144production of molecular mediator involved in inflammatory response (GO:0002532)2.54414766
145histone H3 deacetylation (GO:0070932)2.54014652
146positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.53884493
147histone demethylation (GO:0016577)2.53755409
148negative regulation of mRNA metabolic process (GO:1903312)2.53425951
149negative regulation of myotube differentiation (GO:0010832)2.53267652
150IMP biosynthetic process (GO:0006188)2.52701524
151regulation of ARF protein signal transduction (GO:0032012)2.50969052
152regulation of macrophage cytokine production (GO:0010935)2.50213734
153regulation of mitochondrial depolarization (GO:0051900)2.49866072
154negative regulation of interleukin-6 production (GO:0032715)2.49796683
155negative regulation of mRNA processing (GO:0050686)2.49340829
156activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.48935860
157positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.48819171
158postreplication repair (GO:0006301)2.47665153
159chromatin silencing (GO:0006342)2.47503655
160L-fucose catabolic process (GO:0042355)2.47378621
161fucose catabolic process (GO:0019317)2.47378621
162L-fucose metabolic process (GO:0042354)2.47378621
163antigen processing and presentation of endogenous antigen (GO:0019883)2.46875759
164positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.46745592
165mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.45041503
166vesicle coating (GO:0006901)2.43292498
167positive regulation of histone deacetylation (GO:0031065)2.43292260
168regulation of necrotic cell death (GO:0010939)2.43151854
169regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.42765258
170negative regulation of B cell proliferation (GO:0030889)2.41996358
171negative regulation of type 2 immune response (GO:0002829)2.41632455
172positive regulation of lamellipodium organization (GO:1902745)2.41202906
173cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.40435586
174negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.40193256
175negative regulation of T-helper cell differentiation (GO:0045623)2.40193256
176neutrophil chemotaxis (GO:0030593)2.40060719
177male sex determination (GO:0030238)2.38119252
178regulation of short-term neuronal synaptic plasticity (GO:0048172)2.37870257
179protein autoprocessing (GO:0016540)2.37518385
180telomere maintenance via semi-conservative replication (GO:0032201)2.36809630
181termination of RNA polymerase II transcription (GO:0006369)2.35190934
182positive regulation of lamellipodium assembly (GO:0010592)2.34091933
183protein retention in ER lumen (GO:0006621)2.34073816
184cerebellar Purkinje cell layer development (GO:0021680)2.33103616
185layer formation in cerebral cortex (GO:0021819)2.32955277
186histone H2A acetylation (GO:0043968)2.32705323
187maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.32521941
188pyrimidine nucleobase catabolic process (GO:0006208)2.29864706
189negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.29772725
190regulation of nuclease activity (GO:0032069)2.29742421
191peptidyl-arginine methylation (GO:0018216)2.27556379
192peptidyl-arginine N-methylation (GO:0035246)2.27556379
193regulation of microtubule-based movement (GO:0060632)2.26043845

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.53036769
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.56536826
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.16635592
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.02440435
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.53220788
6MYC_22102868_ChIP-Seq_BL_Human3.38511496
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.18295365
8* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.09276162
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.99544724
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.97193581
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.91233107
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.87816303
13* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.78244437
14VDR_21846776_ChIP-Seq_THP-1_Human2.76942140
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.54002236
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.52198914
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.51967112
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.47732244
19RUNX_20019798_ChIP-Seq_JUKART_Human2.44811060
20EZH2_22144423_ChIP-Seq_EOC_Human2.29982242
21* SCL_19346495_ChIP-Seq_HPC-7_Human2.24853904
22* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.23369513
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.21435664
24GATA2_21666600_ChIP-Seq_HMVEC_Human2.08997380
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.07686693
26VDR_24787735_ChIP-Seq_THP-1_Human2.07253398
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.07127703
28FOXM1_23109430_ChIP-Seq_U2OS_Human2.04597956
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.04516495
30SMAD_19615063_ChIP-ChIP_OVARY_Human2.04273673
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.02875909
32MYB_26560356_Chip-Seq_TH2_Human1.98765313
33* TCF7_22412390_ChIP-Seq_EML_Mouse1.92493146
34CIITA_25753668_ChIP-Seq_RAJI_Human1.90932989
35* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.90170951
36XRN2_22483619_ChIP-Seq_HELA_Human1.88241800
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86270892
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.83259685
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82437373
40MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.79570148
41LXR_22292898_ChIP-Seq_THP-1_Human1.78171883
42* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.76135262
43* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.75292528
44GATA1_22025678_ChIP-Seq_K562_Human1.73362968
45CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.73066034
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.72045705
47* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.71138964
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70671491
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.67275382
50MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65778772
51* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.65616647
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.65094051
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62815763
54* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.60588770
55GABP_19822575_ChIP-Seq_HepG2_Human1.60391477
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.59503325
57* KDM2B_26808549_Chip-Seq_DND41_Human1.59495456
58* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59339044
59* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58332870
60GATA3_27048872_Chip-Seq_THYMUS_Human1.57068044
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.56726160
62MYB_26560356_Chip-Seq_TH1_Human1.56368710
63UTX_26944678_Chip-Seq_JUKART_Human1.54385757
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.54005469
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.53371683
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.52799219
67* ESR1_20079471_ChIP-ChIP_T-47D_Human1.52336500
68STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52128703
69DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50537188
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49028895
71ESR1_15608294_ChIP-ChIP_MCF-7_Human1.48927700
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47302265
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47000587
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45508541
75NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43883813
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.43570036
77TFEB_21752829_ChIP-Seq_HELA_Human1.41986846
78VDR_24763502_ChIP-Seq_THP-1_Human1.41861724
79ERG_20887958_ChIP-Seq_HPC-7_Mouse1.41743838
80PU_27001747_Chip-Seq_BMDM_Mouse1.40590671
81* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.40035256
82SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.39936598
83NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.39540976
84EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39258986
85MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35509457
86FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.35054959
87MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33168218
88GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32679481
89ZNF263_19887448_ChIP-Seq_K562_Human1.30978499
90E2F4_17652178_ChIP-ChIP_JURKAT_Human1.28710844
91* GATA1_19941827_ChIP-Seq_MEL_Mouse1.26462753
92WT1_19549856_ChIP-ChIP_CCG9911_Human1.26118777
93TET1_21451524_ChIP-Seq_MESCs_Mouse1.26020811
94ELF1_20517297_ChIP-Seq_JURKAT_Human1.25726885
95SPI1_23127762_ChIP-Seq_K562_Human1.25306640
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24404291
97* KDM2B_26808549_Chip-Seq_JURKAT_Human1.23496845
98JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.23332690
99PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23141900
100KDM5A_27292631_Chip-Seq_BREAST_Human1.22744902
101SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21038136
102GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19712094
103FOXO3_23340844_ChIP-Seq_DLD1_Human1.19587714
104NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18718973
105* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17657178
106CTCF_18555785_ChIP-Seq_MESCs_Mouse1.17297525
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17297295
108P68_20966046_ChIP-Seq_HELA_Human1.16888556
109* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16489057
110GATA2_19941826_ChIP-Seq_K562_Human1.16457043
111FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16045898
112RARB_27405468_Chip-Seq_BRAIN_Mouse1.15918603
113STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15812045
114* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15619420
115ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14641156
116SPI1_23547873_ChIP-Seq_NB4_Human1.13317236
117RUNX1_22412390_ChIP-Seq_EML_Mouse1.12863768
118* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12271404
119MAF_26560356_Chip-Seq_TH1_Human1.12120188
120YY1_22570637_ChIP-Seq_MALME-3M_Human1.12096302
121ETS1_20019798_ChIP-Seq_JURKAT_Human1.11749688
122CLOCK_20551151_ChIP-Seq_293T_Human1.10993168
123DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10877776
124MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10412819
125SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10190733
126VDR_23849224_ChIP-Seq_CD4+_Human1.09335750
127ELK3_25401928_ChIP-Seq_HUVEC_Human1.08994219
128* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08821292
129BCL6_27268052_Chip-Seq_Bcells_Human1.08191273
130TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.07554679
131* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06764962
132GATA1_19941826_ChIP-Seq_K562_Human1.06612360
133SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05433389
134SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05433389
135PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05053733
136* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05052354
137TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05010939
138CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04504412
139SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03395059
140* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03152912
141* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03082285
142CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01780713
143ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01671187
144STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01299987
145SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00966063
146GATA3_26560356_Chip-Seq_TH2_Human0.99759392
147TTF2_22483619_ChIP-Seq_HELA_Human0.99457929
148ZNF274_21170338_ChIP-Seq_K562_Hela0.99420513
149ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97563591
150* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97412185
151FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97358704
152FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97135131
153FOXP3_21729870_ChIP-Seq_TREG_Human0.96655854
154SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96008480
155TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95971992
156* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95763291
157* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95377719
158CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94940845
159* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92927141
160GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92194264
161* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91882543
162* ESR2_21235772_ChIP-Seq_MCF-7_Human0.88010065
163RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87776053
164* MAF_26560356_Chip-Seq_TH2_Human0.82203522
165JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81967311
166PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81698924
167EGR1_19032775_ChIP-ChIP_M12_Human0.81609143
168NCOR1_26117541_ChIP-Seq_K562_Human0.81162435
169* ESR1_21235772_ChIP-Seq_MCF-7_Human0.79126064

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.29407414
2MP0003436_decreased_susceptibility_to3.47584069
3MP0001835_abnormal_antigen_presentation3.35759183
4MP0003303_peritoneal_inflammation3.22403477
5MP0002909_abnormal_adrenal_gland3.20838295
6MP0008260_abnormal_autophagy2.92079630
7MP0003191_abnormal_cellular_cholesterol2.74958517
8MP0004859_abnormal_synaptic_plasticity2.70052548
9MP0002419_abnormal_innate_immunity2.60179134
10MP0005451_abnormal_body_composition2.47332928
11MP0009785_altered_susceptibility_to2.38119006
12MP0006292_abnormal_olfactory_placode2.31069253
13MP0005025_abnormal_response_to2.27243153
14MP0005464_abnormal_platelet_physiology2.26977644
15MP0006054_spinal_hemorrhage2.26272518
16MP0003172_abnormal_lysosome_physiology2.25293876
17MP0004233_abnormal_muscle_weight2.19806541
18MP0003828_pulmonary_edema2.18356656
19MP0001800_abnormal_humoral_immune2.15004877
20MP0009278_abnormal_bone_marrow2.14800803
21MP0003693_abnormal_embryo_hatching2.12803615
22MP0001545_abnormal_hematopoietic_system2.12384694
23MP0005397_hematopoietic_system_phenotyp2.12384694
24MP0005000_abnormal_immune_tolerance2.08019151
25MP0003283_abnormal_digestive_organ2.07304310
26MP0002396_abnormal_hematopoietic_system2.02406943
27MP0001790_abnormal_immune_system1.98563066
28MP0005387_immune_system_phenotype1.98563066
29MP0002723_abnormal_immune_serum1.98233685
30MP0002452_abnormal_antigen_presenting1.97930533
31MP0010094_abnormal_chromosome_stability1.96750026
32MP0003656_abnormal_erythrocyte_physiolo1.96545636
33MP0002877_abnormal_melanocyte_morpholog1.95677858
34MP0008961_abnormal_basal_metabolism1.95073697
35MP0004808_abnormal_hematopoietic_stem1.94821975
36MP0002148_abnormal_hypersensitivity_rea1.92056504
37MP0002420_abnormal_adaptive_immunity1.87591708
38MP0001819_abnormal_immune_cell1.85303289
39MP0001533_abnormal_skeleton_physiology1.78051931
40MP0002837_dystrophic_cardiac_calcinosis1.77678068
41MP0010155_abnormal_intestine_physiology1.77325514
42MP0009764_decreased_sensitivity_to1.75883300
43MP0004947_skin_inflammation1.75205798
44MP0006082_CNS_inflammation1.68680918
45MP0003111_abnormal_nucleus_morphology1.62570277
46MP0002089_abnormal_postnatal_growth/wei1.59027131
47MP0001944_abnormal_pancreas_morphology1.57523773
48MP0003091_abnormal_cell_migration1.56156017
49MP0005174_abnormal_tail_pigmentation1.55415614
50MP0004883_abnormal_blood_vessel1.54968140
51MP0008877_abnormal_DNA_methylation1.52688673
52MP0000751_myopathy1.52014843
53MP0003635_abnormal_synaptic_transmissio1.51388921
54MP0000569_abnormal_digit_pigmentation1.50575613
55MP0003646_muscle_fatigue1.50289876
56MP0002405_respiratory_system_inflammati1.46752332
57MP0004811_abnormal_neuron_physiology1.46076183
58MP0004043_abnormal_pH_regulation1.45240000
59MP0002693_abnormal_pancreas_physiology1.44835473
60MP0002332_abnormal_exercise_endurance1.42069950
61MP0000716_abnormal_immune_system1.41228588
62MP0005058_abnormal_lysosome_morphology1.39623419
63MP0001845_abnormal_inflammatory_respons1.37889109
64MP0005671_abnormal_response_to1.35532910
65MP0003763_abnormal_thymus_physiology1.35282901
66MP0005164_abnormal_response_to1.33726294
67MP0005646_abnormal_pituitary_gland1.32883017
68MP0003077_abnormal_cell_cycle1.32864572
69MP0001984_abnormal_olfaction1.32667631
70MP0002638_abnormal_pupillary_reflex1.32557106
71MP0003183_abnormal_peptide_metabolism1.29503385
72MP0002166_altered_tumor_susceptibility1.29154235
73MP0003329_amyloid_beta_deposits1.28805903
74MP0001851_eye_inflammation1.27145241
75MP0000490_abnormal_crypts_of1.25991992
76MP0000858_altered_metastatic_potential1.25973023
77MP0000358_abnormal_cell_content/1.25853585
78MP0003300_gastrointestinal_ulcer1.22766238
79MP0002722_abnormal_immune_system1.19982994
80MP0008995_early_reproductive_senescence1.19558444
81MP0004957_abnormal_blastocyst_morpholog1.18496215
82MP0003123_paternal_imprinting1.18466945
83MP0009780_abnormal_chondrocyte_physiolo1.18190322
84MP0004215_abnormal_myocardial_fiber1.14987372
85MP0008469_abnormal_protein_level1.13114336
86MP0002132_abnormal_respiratory_system1.12516520
87MP0002429_abnormal_blood_cell1.10929837
88MP0002998_abnormal_bone_remodeling1.10141218
89MP0003690_abnormal_glial_cell1.09237460
90MP0005645_abnormal_hypothalamus_physiol1.08222527
91MP0002063_abnormal_learning/memory/cond1.07039523
92MP0002398_abnormal_bone_marrow1.05936800
93MP0004147_increased_porphyrin_level1.05016351
94MP0002078_abnormal_glucose_homeostasis1.04044789
95MP0006072_abnormal_retinal_apoptosis1.01842016
96MP0000313_abnormal_cell_death1.01313550
97MP0001730_embryonic_growth_arrest1.00618774
98MP0003448_altered_tumor_morphology1.00547484
99MP0010352_gastrointestinal_tract_polyps1.00256783
100MP0005076_abnormal_cell_differentiation1.00016577
101MP0005220_abnormal_exocrine_pancreas0.99541216
102MP0003221_abnormal_cardiomyocyte_apopto0.97741293
103MP0002653_abnormal_ependyma_morphology0.97633599
104MP0003866_abnormal_defecation0.95998262
105MP0000013_abnormal_adipose_tissue0.95638265
106MP0009765_abnormal_xenobiotic_induced0.95147852
107MP0002080_prenatal_lethality0.94565439
108MP0001929_abnormal_gametogenesis0.94059919
109MP0000703_abnormal_thymus_morphology0.94041424
110MP0000631_abnormal_neuroendocrine_gland0.92485682
111MP0002006_tumorigenesis0.92073281
112MP0008007_abnormal_cellular_replicative0.91740627
113MP0001853_heart_inflammation0.90691973
114MP0006036_abnormal_mitochondrial_physio0.90399629
115MP0005310_abnormal_salivary_gland0.90284872
116MP0002269_muscular_atrophy0.89881110
117MP0008058_abnormal_DNA_repair0.89189476
118MP0010234_abnormal_vibrissa_follicle0.87798172
119MP0000747_muscle_weakness0.87701836
120MP0003566_abnormal_cell_adhesion0.87510193
121MP0004782_abnormal_surfactant_physiolog0.86577296
122MP0008569_lethality_at_weaning0.86267236
123MP0001348_abnormal_lacrimal_gland0.85772118
124MP0004130_abnormal_muscle_cell0.85632407
125MP0003633_abnormal_nervous_system0.85578609
126MP0002928_abnormal_bile_duct0.85500384
127MP0010307_abnormal_tumor_latency0.85500157
128MP0004484_altered_response_of0.85460749
129MP0003121_genomic_imprinting0.84596680
130MP0002733_abnormal_thermal_nociception0.84357958
131MP0001958_emphysema0.83790410
132MP0000465_gastrointestinal_hemorrhage0.83713858
133MP0004264_abnormal_extraembryonic_tissu0.83095638
134MP0002009_preneoplasia0.82904524
135MP0004084_abnormal_cardiac_muscle0.82847154
136MP0005165_increased_susceptibility_to0.82509073
137MP0000343_altered_response_to0.82347937
138MP0002019_abnormal_tumor_incidence0.81553503
139MP0000249_abnormal_blood_vessel0.81244525
140MP0005621_abnormal_cell_physiology0.80850705
141MP0003453_abnormal_keratinocyte_physiol0.79227412
142MP0000350_abnormal_cell_proliferation0.78623128
143MP0003075_altered_response_to0.76844230
144MP0004270_analgesia0.76586588
145MP0005423_abnormal_somatic_nervous0.76341694
146MP0005388_respiratory_system_phenotype0.76237275
147MP0002133_abnormal_respiratory_system0.76237275
148MP0005167_abnormal_blood-brain_barrier0.75912474
149MP0000689_abnormal_spleen_morphology0.75864694
150MP0003122_maternal_imprinting0.75259068
151MP0003698_abnormal_male_reproductive0.74654159
152MP0002084_abnormal_developmental_patter0.73748738
153MP0005166_decreased_susceptibility_to0.73292111
154MP0005390_skeleton_phenotype0.73136370
155MP0001697_abnormal_embryo_size0.72951783
156MP0009763_increased_sensitivity_to0.72869932
157MP0003137_abnormal_impulse_conducting0.72378601
158MP0000681_abnormal_thyroid_gland0.71605446
159MP0003879_abnormal_hair_cell0.71568866
160MP0001970_abnormal_pain_threshold0.71492310
161MP0000955_abnormal_spinal_cord0.71332266
162MP0002210_abnormal_sex_determination0.70889598
163MP0000604_amyloidosis0.70595704
164MP0000685_abnormal_immune_system0.70154475
165MP0003943_abnormal_hepatobiliary_system0.68469289
166MP0010630_abnormal_cardiac_muscle0.65534387
167MP0003567_abnormal_fetal_cardiomyocyte0.63362240
168MP0008874_decreased_physiological_sensi0.63275063

Predicted human phenotypes

RankGene SetZ-score
1Orchitis (HP:0100796)4.76016698
2Myositis (HP:0100614)4.69798856
3Retrobulbar optic neuritis (HP:0100654)4.48995292
4Optic neuritis (HP:0100653)4.48995292
5Eczematoid dermatitis (HP:0000976)4.33410054
6Hyperacusis (HP:0010780)4.32182572
7Recurrent abscess formation (HP:0002722)4.30426279
8Recurrent bacterial skin infections (HP:0005406)4.10587753
9Insomnia (HP:0100785)3.89404381
10Visual hallucinations (HP:0002367)3.88934761
11Elevated erythrocyte sedimentation rate (HP:0003565)3.76581921
12Papilledema (HP:0001085)3.61530381
13Ependymoma (HP:0002888)3.55516559
14Elfin facies (HP:0004428)3.38888628
15Abnormality of macrophages (HP:0004311)3.33832330
16Gastrointestinal infarctions (HP:0005244)3.29121054
17Stomatitis (HP:0010280)3.27833916
18Keratoconjunctivitis sicca (HP:0001097)3.26496401
19Mediastinal lymphadenopathy (HP:0100721)3.18468595
20Recurrent gram-negative bacterial infections (HP:0005420)3.16875633
21Peritonitis (HP:0002586)3.12617414
22Increased IgM level (HP:0003496)3.06041492
23Gingival bleeding (HP:0000225)3.01743477
24Abnormal delayed hypersensitivity skin test (HP:0002963)2.93281734
25Amyotrophic lateral sclerosis (HP:0007354)2.92553467
26Neoplasm of the heart (HP:0100544)2.90458916
27Urticaria (HP:0001025)2.86877264
28Recurrent fungal infections (HP:0002841)2.85349783
29Gingivitis (HP:0000230)2.83281510
30Keratoconjunctivitis (HP:0001096)2.82877339
31Abnormality of the heme biosynthetic pathway (HP:0010472)2.82818932
32Pulmonary infiltrates (HP:0002113)2.79766122
33Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.76655424
34Chest pain (HP:0100749)2.76501217
35Abnormality of the astrocytes (HP:0100707)2.74986363
36Astrocytoma (HP:0009592)2.74986363
37Recurrent skin infections (HP:0001581)2.71436432
38Renovascular hypertension (HP:0100817)2.70718266
39Meningitis (HP:0001287)2.70180778
40Encephalitis (HP:0002383)2.66789961
41Arterial thrombosis (HP:0004420)2.65828183
42Vasculitis (HP:0002633)2.61543644
43Ankle clonus (HP:0011448)2.61504680
44Episodic fever (HP:0001954)2.58776314
45Overriding aorta (HP:0002623)2.57724234
46Leukocytosis (HP:0001974)2.56038733
47Recurrent cutaneous fungal infections (HP:0011370)2.51943941
48Chronic mucocutaneous candidiasis (HP:0002728)2.51943941
49Subacute progressive viral hepatitis (HP:0006572)2.51455885
50Hand muscle atrophy (HP:0009130)2.51276647
51Late onset (HP:0003584)2.51097648
52Abnormality of T cell number (HP:0011839)2.50348495
53T lymphocytopenia (HP:0005403)2.45569715
54Granulocytopenia (HP:0001913)2.45561037
55Urinary urgency (HP:0000012)2.45385495
56Chronic obstructive pulmonary disease (HP:0006510)2.42840287
57Obstructive lung disease (HP:0006536)2.42840287
58Renal duplication (HP:0000075)2.42753289
59Depression (HP:0000716)2.42383818
60Abnormality of the peritoneum (HP:0002585)2.42342300
61Spontaneous hematomas (HP:0007420)2.41925072
62Viral hepatitis (HP:0006562)2.41114462
63Recurrent viral infections (HP:0004429)2.34846266
64Abnormality of the pancreatic islet cells (HP:0006476)2.34395487
65Abnormality of endocrine pancreas physiology (HP:0012093)2.34395487
66Diminished motivation (HP:0000745)2.33016160
67Atrophy/Degeneration involving motor neurons (HP:0007373)2.32784950
68Increased IgE level (HP:0003212)2.32099318
69Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.31424137
70Hypergammaglobulinemia (HP:0010702)2.30932388
71Hemoptysis (HP:0002105)2.30575791
72Impaired smooth pursuit (HP:0007772)2.29802048
73Acute lymphatic leukemia (HP:0006721)2.29030124
74Abnormality of the periventricular white matter (HP:0002518)2.27812424
75Angiofibromas (HP:0010615)2.27405495
76Adenoma sebaceum (HP:0009720)2.27405495
77Eosinophilia (HP:0001880)2.26708589
78Epistaxis (HP:0000421)2.25550619
79Amyloidosis (HP:0011034)2.25381248
80Interstitial pulmonary disease (HP:0006530)2.24861149
81Impaired vibration sensation in the lower limbs (HP:0002166)2.23519155
82Agitation (HP:0000713)2.23061855
83Autoimmune thrombocytopenia (HP:0001973)2.21984236
84Lymphangioma (HP:0100764)2.18928471
85Abnormality of the endocardium (HP:0004306)2.18334814
86Apathy (HP:0000741)2.16477222
87Stomach cancer (HP:0012126)2.13791990
88Broad alveolar ridges (HP:0000187)2.13201715
89Hyperinsulinemic hypoglycemia (HP:0000825)2.12180016
90Papillary thyroid carcinoma (HP:0002895)2.10620437
91Pointed chin (HP:0000307)2.10371425
92Prolonged bleeding time (HP:0003010)2.09707168
93Global brain atrophy (HP:0002283)2.06113434
94Flat cornea (HP:0007720)2.06074475
95Abnormality of ocular smooth pursuit (HP:0000617)2.05644905
96Exercise-induced myalgia (HP:0003738)2.05493102
97Autoimmune hemolytic anemia (HP:0001890)2.04470553
98Slender long bone (HP:0003100)2.04047097
99Ketoacidosis (HP:0001993)2.03965322
100Abnormality of the pleura (HP:0002103)2.03836531
101Macroorchidism (HP:0000053)2.01744166
102Supranuclear gaze palsy (HP:0000605)2.01586583
103Anorexia (HP:0002039)2.01486248
104Increased nuchal translucency (HP:0010880)2.01307007
105Abnormality of the fingertips (HP:0001211)2.01296051
106Distal upper limb amyotrophy (HP:0007149)2.01011890
107Upper limb amyotrophy (HP:0009129)2.01011890
108Failure to thrive in infancy (HP:0001531)2.00615391
109Glioma (HP:0009733)1.99976680
110Tongue fasciculations (HP:0001308)1.98529250
111Clonus (HP:0002169)1.96265312
112Neoplasm of the tracheobronchial system (HP:0100552)1.95499201
113Increased cerebral lipofuscin (HP:0011813)1.93148099
114Metaphyseal cupping (HP:0003021)1.92128374
115Nasal polyposis (HP:0100582)1.91861746
116Abnormality of the lower motor neuron (HP:0002366)1.90883559
117Abnormality of the nasal mucosa (HP:0000433)1.90398238
118Hypoglycemic seizures (HP:0002173)1.90201403
119Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.90088461
120Gangrene (HP:0100758)1.89522033
121Osteomyelitis (HP:0002754)1.89342943
122Pulmonary embolism (HP:0002204)1.89267714
123Progressive neurologic deterioration (HP:0002344)1.89218001
124Severe global developmental delay (HP:0011344)1.89167069
125Alveolar cell carcinoma (HP:0006519)1.88947111
126Difficulty running (HP:0009046)1.88796462
127Hyperkalemia (HP:0002153)1.88756178
128Aplastic anemia (HP:0001915)1.88418138
129Curly hair (HP:0002212)1.88005703
130Abnormality of eosinophils (HP:0001879)1.86832772
131Severe short stature (HP:0003510)1.86728132
132Tubulointerstitial nephritis (HP:0001970)1.85924990
133Megalocornea (HP:0000485)1.85318838
134Dysostosis multiplex (HP:0000943)1.84647930
135IgM deficiency (HP:0002850)1.84425130
136Abnormal number of erythroid precursors (HP:0012131)1.83311122
137Abnormality of the anterior horn cell (HP:0006802)1.83142662
138Degeneration of anterior horn cells (HP:0002398)1.83142662
139Mucopolysacchariduria (HP:0008155)1.82885577
140Urinary glycosaminoglycan excretion (HP:0003541)1.82885577
141Bowel diverticulosis (HP:0005222)1.82498762
142Abnormality of T cells (HP:0002843)1.81442944
143Arterial tortuosity (HP:0005116)1.80935477
144Chronic otitis media (HP:0000389)1.77011880
145Urinary bladder sphincter dysfunction (HP:0002839)1.76205466
146Neuronal loss in central nervous system (HP:0002529)1.76079686
147Hypochromic microcytic anemia (HP:0004840)1.76027893
148Hypoglycemic coma (HP:0001325)1.75898081
149Abnormality of mucopolysaccharide metabolism (HP:0011020)1.75521599
150Abnormality of polysaccharide metabolism (HP:0011012)1.75521599
151Abnormality of glycosaminoglycan metabolism (HP:0004371)1.75521599
152Large eyes (HP:0001090)1.75377751
153Muscle fibrillation (HP:0010546)1.74639907
154Disinhibition (HP:0000734)1.73529036
155Hypochromic anemia (HP:0001931)1.73520406
156Limb-girdle muscle atrophy (HP:0003797)1.73147829
157Coarse hair (HP:0002208)1.72684069
158Inappropriate behavior (HP:0000719)1.71147921
159Inflammation of the large intestine (HP:0002037)1.70646380
160Poikiloderma (HP:0001029)1.70513430
161Abnormal platelet volume (HP:0011876)1.69166589
162Abnormality of the motor neurons (HP:0002450)1.68874921
163Abnormal neuron morphology (HP:0012757)1.68874921
164Pelvic girdle muscle weakness (HP:0003749)1.68701993
165Symptomatic seizures (HP:0011145)1.68646023
166Obsessive-compulsive behavior (HP:0000722)1.68496131
167Loss of speech (HP:0002371)1.67968400
168Colitis (HP:0002583)1.66738983
169Gastrointestinal inflammation (HP:0004386)1.66660490
170Panhypogammaglobulinemia (HP:0003139)1.66230413
171Microcytic anemia (HP:0001935)1.66099313
172Glomerulopathy (HP:0100820)1.66082165
173Vertigo (HP:0002321)1.65631880
174Polyphagia (HP:0002591)1.65356690
175Basal cell carcinoma (HP:0002671)1.65235793
176Neoplasm of the adrenal gland (HP:0100631)1.64775385
177Syringomyelia (HP:0003396)1.64759012
178Spinal cord lesions (HP:0100561)1.64759012
179Skin ulcer (HP:0200042)1.64595588
180Flat acetabular roof (HP:0003180)1.64322361
181Fatigue (HP:0012378)1.64312149
182Abnormality of glycosphingolipid metabolism (HP:0004343)1.64108110
183Generalized hyperpigmentation (HP:0007440)1.63580741
184Generalized aminoaciduria (HP:0002909)1.63534481
185Sacral dimple (HP:0000960)1.63320020
186Abnormality of cells of the erythroid lineage (HP:0012130)1.61791721
187Severe muscular hypotonia (HP:0006829)1.61158837
188Hamartoma of the eye (HP:0010568)1.60225951
189Fibroma (HP:0010614)1.59895932
190Spinal canal stenosis (HP:0003416)1.59047699
191Large for gestational age (HP:0001520)1.58782958
192Neurodegeneration (HP:0002180)1.57860690
193Cerebral aneurysm (HP:0004944)1.57253380
194Asymmetric septal hypertrophy (HP:0001670)1.56838979
195Cellulitis (HP:0100658)1.56381961

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR7.44452836
2SCYL23.67738010
3RIPK43.48019230
4EEF2K2.72019588
5DYRK32.68057624
6TRIB32.57730048
7PKN22.43125386
8MAP3K142.38063773
9EPHB12.22935716
10MAP2K32.15474272
11MAP4K12.14389827
12IRAK42.13473211
13TNIK2.01957692
14CSK1.98663196
15TXK1.91723235
16MAP3K101.84978174
17MARK11.79820730
18UHMK11.71824516
19PASK1.69643609
20DYRK1B1.69408413
21ACVR1B1.60727178
22TYK21.60413036
23FGR1.59224032
24MAP3K91.53787198
25FLT31.52204334
26DAPK11.50203900
27MAP2K41.43698627
28MAP3K61.42839722
29HIPK21.41766031
30PRPF4B1.39502681
31HCK1.34850618
32MAPKAPK31.29095926
33MARK21.26231269
34IKBKE1.24396894
35CDC71.24248583
36NEK21.23446889
37WNK11.22433310
38EPHA31.16800032
39YES11.16342009
40JAK11.16231470
41PDGFRA1.14475290
42CAMKK21.12554618
43MAP2K71.11028867
44MAP3K131.10143948
45MAP3K111.08936690
46ICK1.06655919
47KIT1.06610920
48TTN1.04339875
49MAP3K71.04269235
50PRKD21.03849754
51KSR21.02644504
52BCR1.01990136
53MAPK151.01912311
54LYN0.98907398
55PTK2B0.98201059
56GRK60.98113754
57KSR10.96860353
58MINK10.96655439
59RPS6KB20.96602897
60CDK190.96013134
61BTK0.95900615
62SIK20.94759410
63NEK10.93961930
64LCK0.90522406
65PIK3CG0.89788628
66CAMKK10.89343342
67ATR0.89017653
68TNK20.87402224
69PRKD30.87209782
70BCKDK0.87126436
71MAP3K30.86960978
72ERN10.86906344
73PAK40.86895147
74CAMK10.86150871
75BLK0.85760536
76CLK10.84670761
77MST1R0.83912382
78TGFBR10.83205797
79FGFR30.81022984
80FES0.79881351
81LRRK20.78473526
82DYRK20.77969487
83CAMK40.73606364
84BMPR20.72039206
85SIK10.71935329
86MATK0.71718620
87MAP3K50.71351314
88NTRK20.71306367
89IRAK10.70405168
90MAP3K10.70345339
91OBSCN0.70082290
92STK160.69814388
93SGK30.68302656
94WNK30.67773450
95RPS6KA20.67310272
96RET0.67282374
97TESK20.67189508
98ERBB30.66648991
99RIPK10.65582136
100MAPK110.65401771
101FYN0.64498753
102RAF10.63465617
103SIK30.62519158
104CDK50.62186171
105MET0.60907323
106MAP3K120.60730639
107PAK30.60622457
108MAPK130.60545357
109TYRO30.59674791
110CHUK0.59326922
111SYK0.59069360
112IRAK30.57474779
113IRAK20.56668830
114MAP3K20.56391044
115TEC0.55859534
116NEK90.55371265
117TAOK30.53233017
118PTK60.52551539
119PRKAA10.51405990
120PAK60.51112216
121TBK10.50293830
122PHKG20.49466162
123PHKG10.49466162
124ERBB20.49023673
125PIK3CA0.48732261
126PDGFRB0.48700195
127DYRK1A0.48607249
128GRK70.48408221
129ALK0.48203445
130STK100.47693448
131PDK10.47527217
132PDPK10.47427055
133CSF1R0.46458655
134MAP3K40.45771855
135SGK20.44543897
136ZAP700.44508545
137CDC42BPA0.44298834
138CDK60.44200450
139BRD40.43523590
140IKBKB0.43503832
141JAK20.43382827
142PAK20.43355521
143MAPK70.43325800
144VRK10.42017654
145RPS6KA60.41887689
146TAOK10.40838937
147ILK0.40719629
148CDK180.40516872
149RPS6KA40.40167414
150CDK150.38337727
151NTRK30.37924535
152MAP2K20.37316155
153CDK11A0.37215518
154RPS6KL10.33269448
155RPS6KC10.33269448
156MTOR0.31870723
157JAK30.31731890
158CDK40.31552291
159TLK10.31249377
160MAPK40.30640931
161CDK120.30223145

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.95105051
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.70578655
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.48911898
4Leishmaniasis_Homo sapiens_hsa051402.24507587
5Osteoclast differentiation_Homo sapiens_hsa043802.22409629
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.01445790
7Mismatch repair_Homo sapiens_hsa034301.89016121
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.81310626
9Tuberculosis_Homo sapiens_hsa051521.79676958
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.76500034
11Sulfur relay system_Homo sapiens_hsa041221.74927055
12N-Glycan biosynthesis_Homo sapiens_hsa005101.70073600
13mTOR signaling pathway_Homo sapiens_hsa041501.65902424
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.65712459
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.65237027
16Base excision repair_Homo sapiens_hsa034101.58442995
17Type II diabetes mellitus_Homo sapiens_hsa049301.57334528
18Malaria_Homo sapiens_hsa051441.55373473
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.55182603
20Staphylococcus aureus infection_Homo sapiens_hsa051501.53984058
21Carbohydrate digestion and absorption_Homo sapiens_hsa049731.53129105
22Spliceosome_Homo sapiens_hsa030401.52925178
23Hepatitis C_Homo sapiens_hsa051601.49786236
24Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.47492543
25Renal cell carcinoma_Homo sapiens_hsa052111.43040096
26Chronic myeloid leukemia_Homo sapiens_hsa052201.41782123
27Insulin secretion_Homo sapiens_hsa049111.40602512
28Toxoplasmosis_Homo sapiens_hsa051451.40065240
29Viral myocarditis_Homo sapiens_hsa054161.37817500
30Influenza A_Homo sapiens_hsa051641.37730875
31Measles_Homo sapiens_hsa051621.36627276
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.35904151
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.35479703
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35180187
35Colorectal cancer_Homo sapiens_hsa052101.35032143
36Alcoholism_Homo sapiens_hsa050341.34248655
37Salmonella infection_Homo sapiens_hsa051321.31972894
38TNF signaling pathway_Homo sapiens_hsa046681.30462704
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.28535305
40Hepatitis B_Homo sapiens_hsa051611.27427585
41VEGF signaling pathway_Homo sapiens_hsa043701.26750008
42Chemokine signaling pathway_Homo sapiens_hsa040621.26181453
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.24170349
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.21801108
45T cell receptor signaling pathway_Homo sapiens_hsa046601.21197953
46Thyroid hormone signaling pathway_Homo sapiens_hsa049191.20463486
47Cell cycle_Homo sapiens_hsa041101.19657652
48B cell receptor signaling pathway_Homo sapiens_hsa046621.18819703
49Hematopoietic cell lineage_Homo sapiens_hsa046401.18282864
50Non-small cell lung cancer_Homo sapiens_hsa052231.18007880
51NF-kappa B signaling pathway_Homo sapiens_hsa040641.17643439
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17303660
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16742073
54Phagosome_Homo sapiens_hsa041451.15509645
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14805949
56RNA transport_Homo sapiens_hsa030131.13133793
57Acute myeloid leukemia_Homo sapiens_hsa052211.12065911
58Insulin signaling pathway_Homo sapiens_hsa049101.11070872
59Thyroid cancer_Homo sapiens_hsa052161.10425852
60Pertussis_Homo sapiens_hsa051331.06695138
61Choline metabolism in cancer_Homo sapiens_hsa052311.06374184
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05980057
63Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.05944372
64mRNA surveillance pathway_Homo sapiens_hsa030151.05260539
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.04166270
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03628248
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03482491
68Oocyte meiosis_Homo sapiens_hsa041141.03317357
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02764518
70Apoptosis_Homo sapiens_hsa042101.02302520
71Glycosaminoglycan degradation_Homo sapiens_hsa005311.01741504
72Glioma_Homo sapiens_hsa052140.98499274
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98366105
74Amoebiasis_Homo sapiens_hsa051460.98082170
75Dopaminergic synapse_Homo sapiens_hsa047280.96848771
76Shigellosis_Homo sapiens_hsa051310.96580097
77Olfactory transduction_Homo sapiens_hsa047400.95293357
78Endometrial cancer_Homo sapiens_hsa052130.95004473
79Long-term potentiation_Homo sapiens_hsa047200.94327194
80Autoimmune thyroid disease_Homo sapiens_hsa053200.93719550
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.93163858
82Other glycan degradation_Homo sapiens_hsa005110.92092496
83Graft-versus-host disease_Homo sapiens_hsa053320.91387418
84Allograft rejection_Homo sapiens_hsa053300.90662400
85Selenocompound metabolism_Homo sapiens_hsa004500.90484525
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90325922
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88840677
88ErbB signaling pathway_Homo sapiens_hsa040120.88104283
89Estrogen signaling pathway_Homo sapiens_hsa049150.88081980
90Endocytosis_Homo sapiens_hsa041440.86540905
91Dorso-ventral axis formation_Homo sapiens_hsa043200.85923279
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85437969
93Fatty acid biosynthesis_Homo sapiens_hsa000610.85328681
94Antigen processing and presentation_Homo sapiens_hsa046120.84182807
95Gap junction_Homo sapiens_hsa045400.83853080
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83824202
97Prolactin signaling pathway_Homo sapiens_hsa049170.83693490
98African trypanosomiasis_Homo sapiens_hsa051430.83568019
99FoxO signaling pathway_Homo sapiens_hsa040680.82679065
100* Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81573049
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79412715
102Viral carcinogenesis_Homo sapiens_hsa052030.79294617
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79036447
104Glucagon signaling pathway_Homo sapiens_hsa049220.78436389
105AMPK signaling pathway_Homo sapiens_hsa041520.77737822
106Primary immunodeficiency_Homo sapiens_hsa053400.77687295
107Cocaine addiction_Homo sapiens_hsa050300.77568500
108Insulin resistance_Homo sapiens_hsa049310.77308698
109Circadian entrainment_Homo sapiens_hsa047130.76960095
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.76898135
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76297447
112Gastric acid secretion_Homo sapiens_hsa049710.74059790
113Synaptic vesicle cycle_Homo sapiens_hsa047210.73770628
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73503156
115Pancreatic cancer_Homo sapiens_hsa052120.73056734
116Inositol phosphate metabolism_Homo sapiens_hsa005620.72847929
117Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72701301
118Cholinergic synapse_Homo sapiens_hsa047250.72176045
119Platelet activation_Homo sapiens_hsa046110.71716245
120Prostate cancer_Homo sapiens_hsa052150.71396714
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70599774
122p53 signaling pathway_Homo sapiens_hsa041150.69813789
123Bladder cancer_Homo sapiens_hsa052190.66933496
124Regulation of autophagy_Homo sapiens_hsa041400.64472770
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64225997
126Lysine degradation_Homo sapiens_hsa003100.64161005
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62324264
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61690907
129Pentose phosphate pathway_Homo sapiens_hsa000300.61643317
130* Pyrimidine metabolism_Homo sapiens_hsa002400.60809601
131Glutamatergic synapse_Homo sapiens_hsa047240.59492223
132Small cell lung cancer_Homo sapiens_hsa052220.58717117
133Amphetamine addiction_Homo sapiens_hsa050310.58110659
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57778369
135Proteoglycans in cancer_Homo sapiens_hsa052050.57653103
136Notch signaling pathway_Homo sapiens_hsa043300.56623410
137GABAergic synapse_Homo sapiens_hsa047270.56039403
138Focal adhesion_Homo sapiens_hsa045100.55996833
139Lysosome_Homo sapiens_hsa041420.55449704
140Ribosome_Homo sapiens_hsa030100.54896716
141Type I diabetes mellitus_Homo sapiens_hsa049400.54401437
142cAMP signaling pathway_Homo sapiens_hsa040240.54120188
143Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53572393
144Asthma_Homo sapiens_hsa053100.53049142
145Legionellosis_Homo sapiens_hsa051340.52475854
146Herpes simplex infection_Homo sapiens_hsa051680.52421820
147Rap1 signaling pathway_Homo sapiens_hsa040150.52417206
148Systemic lupus erythematosus_Homo sapiens_hsa053220.52279970
149GnRH signaling pathway_Homo sapiens_hsa049120.51792540
150Oxytocin signaling pathway_Homo sapiens_hsa049210.51513521
151Sphingolipid signaling pathway_Homo sapiens_hsa040710.51159015
152HIF-1 signaling pathway_Homo sapiens_hsa040660.50677178
153Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49534754
154Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49195900
155Phospholipase D signaling pathway_Homo sapiens_hsa040720.48505623
156Circadian rhythm_Homo sapiens_hsa047100.48052583
157Nucleotide excision repair_Homo sapiens_hsa034200.47066558
158Thyroid hormone synthesis_Homo sapiens_hsa049180.46821530
159Morphine addiction_Homo sapiens_hsa050320.46726891

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »