NT5C3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.18071232
2DNA deamination (GO:0045006)4.68094814
3maturation of SSU-rRNA (GO:0030490)4.55626878
4DNA strand elongation involved in DNA replication (GO:0006271)4.53234225
5telomere maintenance via semi-conservative replication (GO:0032201)4.47862541
6peptidyl-arginine omega-N-methylation (GO:0035247)4.45825863
7nucleobase biosynthetic process (GO:0046112)4.35888137
8DNA strand elongation (GO:0022616)4.35772793
9purine nucleobase biosynthetic process (GO:0009113)4.33026073
10DNA replication initiation (GO:0006270)4.12487587
11histone arginine methylation (GO:0034969)4.05142586
12telomere maintenance via recombination (GO:0000722)4.00722212
13formation of translation preinitiation complex (GO:0001731)3.98539321
14DNA replication checkpoint (GO:0000076)3.98537088
15proteasome assembly (GO:0043248)3.95711202
16viral transcription (GO:0019083)3.89514010
17regulation of mitochondrial translation (GO:0070129)3.83499984
18deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.79509937
19ribosome biogenesis (GO:0042254)3.79451704
20translational termination (GO:0006415)3.79061240
21peptidyl-arginine N-methylation (GO:0035246)3.76919773
22peptidyl-arginine methylation (GO:0018216)3.76919773
23mitotic recombination (GO:0006312)3.73554116
24ribosomal large subunit biogenesis (GO:0042273)3.73191128
25ribonucleoprotein complex biogenesis (GO:0022613)3.65358955
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.62452814
27transcription elongation from RNA polymerase III promoter (GO:0006385)3.61392356
28termination of RNA polymerase III transcription (GO:0006386)3.61392356
29translational elongation (GO:0006414)3.58577136
30telomere maintenance via telomere lengthening (GO:0010833)3.56433987
31nucleotide-excision repair, DNA gap filling (GO:0006297)3.51783645
32spliceosomal snRNP assembly (GO:0000387)3.51606922
33anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.47590669
34translational initiation (GO:0006413)3.47558538
35L-serine metabolic process (GO:0006563)3.47261758
36regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.46818847
37ribosomal small subunit biogenesis (GO:0042274)3.44227906
38positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.43621844
39DNA unwinding involved in DNA replication (GO:0006268)3.40155836
40cullin deneddylation (GO:0010388)3.36273526
41rRNA processing (GO:0006364)3.36270154
42rRNA modification (GO:0000154)3.34890062
43metallo-sulfur cluster assembly (GO:0031163)3.34310117
44iron-sulfur cluster assembly (GO:0016226)3.34310117
45positive regulation of mitochondrial fission (GO:0090141)3.32424126
46negative regulation of ligase activity (GO:0051352)3.32361807
47negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.32361807
48transcription-coupled nucleotide-excision repair (GO:0006283)3.29885037
49protein localization to kinetochore (GO:0034501)3.29232140
50ribosome assembly (GO:0042255)3.26316001
51nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.26193304
52chaperone-mediated protein transport (GO:0072321)3.25737890
53SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.25287895
54regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.24963755
55rRNA metabolic process (GO:0016072)3.24384163
56pseudouridine synthesis (GO:0001522)3.18952772
577-methylguanosine mRNA capping (GO:0006370)3.16526758
58protein deneddylation (GO:0000338)3.15758334
59cotranslational protein targeting to membrane (GO:0006613)3.14232654
60viral mRNA export from host cell nucleus (GO:0046784)3.14077828
61CENP-A containing nucleosome assembly (GO:0034080)3.13894335
62protein targeting to ER (GO:0045047)3.12213025
63cellular protein complex disassembly (GO:0043624)3.12033778
64pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.11290677
65IMP biosynthetic process (GO:0006188)3.09115538
66RNA capping (GO:0036260)3.08676979
677-methylguanosine RNA capping (GO:0009452)3.08676979
68peptidyl-histidine modification (GO:0018202)3.08594458
69mitotic metaphase plate congression (GO:0007080)3.07871655
70DNA replication-independent nucleosome organization (GO:0034724)3.05991836
71DNA replication-independent nucleosome assembly (GO:0006336)3.05991836
72termination of RNA polymerase I transcription (GO:0006363)3.05741429
73G1/S transition of mitotic cell cycle (GO:0000082)3.04800962
74cell cycle G1/S phase transition (GO:0044843)3.04800962
75GMP metabolic process (GO:0046037)3.04155985
76DNA replication-dependent nucleosome organization (GO:0034723)3.03312315
77DNA replication-dependent nucleosome assembly (GO:0006335)3.03312315
78protein maturation by protein folding (GO:0022417)3.03283070
79pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.01563841
80CTP biosynthetic process (GO:0006241)3.01466260
81CTP metabolic process (GO:0046036)3.01466260
82translation (GO:0006412)3.00561285
83establishment of mitochondrion localization (GO:0051654)3.00159340
84chromatin remodeling at centromere (GO:0031055)3.00088216
85mitotic nuclear envelope disassembly (GO:0007077)2.99952080
86transcription elongation from RNA polymerase I promoter (GO:0006362)2.98475067
87pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.97917754
88protein localization to endoplasmic reticulum (GO:0070972)2.96309848
89viral life cycle (GO:0019058)2.95758423
90establishment of protein localization to endoplasmic reticulum (GO:0072599)2.95565013
91cellular component biogenesis (GO:0044085)2.94863904
92protein targeting to mitochondrion (GO:0006626)2.94535882
93positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.94229132
94DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.93264110
95negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.92297906
96signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.92222031
97signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.92222031
98signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.92222031
99signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.90102467
100intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.90102467
101UTP biosynthetic process (GO:0006228)2.89859697
102regulation of translational fidelity (GO:0006450)2.89818596
103negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.89285158
104negative regulation of sister chromatid segregation (GO:0033046)2.89285158
105negative regulation of mitotic sister chromatid separation (GO:2000816)2.89285158
106negative regulation of mitotic sister chromatid segregation (GO:0033048)2.89285158
107GTP biosynthetic process (GO:0006183)2.88746113
108transcription from RNA polymerase I promoter (GO:0006360)2.88318624
109L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.87896333
110signal transduction involved in DNA damage checkpoint (GO:0072422)2.87658173
111signal transduction involved in DNA integrity checkpoint (GO:0072401)2.87658173
112pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.87060313
113negative regulation of chromosome segregation (GO:0051985)2.86580023
114protein complex disassembly (GO:0043241)2.86291757
115DNA damage response, detection of DNA damage (GO:0042769)2.85523116
116spliceosomal complex assembly (GO:0000245)2.84595680
117signal transduction involved in cell cycle checkpoint (GO:0072395)2.84284160
118DNA-templated transcription, termination (GO:0006353)2.83901748
119pyrimidine nucleobase catabolic process (GO:0006208)2.83613048
120postreplication repair (GO:0006301)2.82805182
121exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.82534357
122guanosine-containing compound biosynthetic process (GO:1901070)2.82077914
123mitotic spindle assembly checkpoint (GO:0007094)2.81879840
124nuclear-transcribed mRNA catabolic process (GO:0000956)2.81700492
125establishment of protein localization to mitochondrion (GO:0072655)2.81497296
126RNA splicing, via transesterification reactions (GO:0000375)2.81386159
127mRNA splicing, via spliceosome (GO:0000398)2.81131143
128de novo posttranslational protein folding (GO:0051084)2.75419540
129de novo protein folding (GO:0006458)2.74391693
130rRNA transcription (GO:0009303)2.71419838
131proline biosynthetic process (GO:0006561)2.71239510
132pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.71195322
133UTP metabolic process (GO:0046051)2.71012348
134oxidative phosphorylation (GO:0006119)2.68881657
135protein localization to mitochondrion (GO:0070585)2.68519948
136regulation of mammary gland epithelial cell proliferation (GO:0033599)2.67192131
137mitochondrial respiratory chain complex assembly (GO:0033108)2.64847738
138protein complex biogenesis (GO:0070271)2.59599615
139cell migration in hindbrain (GO:0021535)2.58867942
140nucleobase-containing small molecule interconversion (GO:0015949)2.58430254
141mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.57555032
142mitochondrial respiratory chain complex I assembly (GO:0032981)2.57555032
143NADH dehydrogenase complex assembly (GO:0010257)2.57555032
144establishment of protein localization to mitochondrial membrane (GO:0090151)2.54498786
145protein insertion into membrane (GO:0051205)2.51086755
146mitochondrial RNA metabolic process (GO:0000959)2.47443356
147serine family amino acid biosynthetic process (GO:0009070)2.47263751
148synaptic vesicle maturation (GO:0016188)2.44580577
149establishment of integrated proviral latency (GO:0075713)2.43050516
150negative regulation of mRNA processing (GO:0050686)2.41421388
151tRNA aminoacylation for protein translation (GO:0006418)2.40795935
152pyrimidine nucleotide catabolic process (GO:0006244)2.40289815
153tRNA aminoacylation (GO:0043039)2.39452799
154amino acid activation (GO:0043038)2.39452799
155base-excision repair, AP site formation (GO:0006285)2.39400411
156COPI coating of Golgi vesicle (GO:0048205)2.35972443
157Golgi transport vesicle coating (GO:0048200)2.35972443
158heterochromatin organization (GO:0070828)2.34980659
159regulation of short-term neuronal synaptic plasticity (GO:0048172)2.33756111
160spliceosomal tri-snRNP complex assembly (GO:0000244)2.33502010
161mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.32982690
162negative regulation of RNA splicing (GO:0033119)2.31544897
163protein retention in ER lumen (GO:0006621)2.31369904
164transcription from mitochondrial promoter (GO:0006390)2.30208665
165establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.29750961
166mitochondrion transport along microtubule (GO:0047497)2.29750961
167synaptic vesicle exocytosis (GO:0016079)2.28792871
168regulation of translational elongation (GO:0006448)2.28353794
169ATP synthesis coupled proton transport (GO:0015986)2.27646531
170energy coupled proton transport, down electrochemical gradient (GO:0015985)2.27646531
171maturation of 5.8S rRNA (GO:0000460)2.26748059
172regulation of cellular respiration (GO:0043457)2.26177012
173mitotic nuclear envelope reassembly (GO:0007084)2.25198582
174nuclear envelope reassembly (GO:0031468)2.25198582
175protein-cofactor linkage (GO:0018065)2.23391462

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.79119468
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.20397151
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.82655642
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.56414074
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.36799775
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.32860310
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.29865281
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.26064033
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.22179110
10MYC_19079543_ChIP-ChIP_MESCs_Mouse3.03669428
11MYC_18358816_ChIP-ChIP_MESCs_Mouse3.02829525
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.01060840
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.98269229
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.83050736
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.82911943
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.75873763
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.75148016
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58940279
19VDR_23849224_ChIP-Seq_CD4+_Human2.49248268
20XRN2_22483619_ChIP-Seq_HELA_Human2.49100132
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.36411266
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32789709
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.31804782
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.24442781
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.23235392
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.21000853
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19918007
28FOXP3_21729870_ChIP-Seq_TREG_Human2.17196674
29GABP_19822575_ChIP-Seq_HepG2_Human2.11132615
30DCP1A_22483619_ChIP-Seq_HELA_Human2.09529422
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.05056874
32CIITA_25753668_ChIP-Seq_RAJI_Human2.02061857
33TTF2_22483619_ChIP-Seq_HELA_Human1.99128664
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.97858596
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96799522
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.91819291
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.91568630
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.86026907
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85581942
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82694650
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79989976
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.79753970
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.74277873
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.74152333
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72288468
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.71176331
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70397975
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.68749179
49ELK1_19687146_ChIP-ChIP_HELA_Human1.68002216
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.67801315
51MYC_22102868_ChIP-Seq_BL_Human1.65856701
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62393421
53AR_21909140_ChIP-Seq_LNCAP_Human1.61925241
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61565699
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56221948
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53889305
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.53734543
58ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.51356271
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.50947887
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.50471549
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.49057416
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48540104
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.48180355
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.43305669
65ZNF263_19887448_ChIP-Seq_K562_Human1.38683191
66ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.38680531
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37134847
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32715877
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31185364
70FOXP1_21924763_ChIP-Seq_HESCs_Human1.29855189
71TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.29728412
72TET1_21451524_ChIP-Seq_MESCs_Mouse1.28512286
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28436911
74KDM5A_27292631_Chip-Seq_BREAST_Human1.27317745
75SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.24652859
76KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.24039338
77SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.22254096
78ELK1_22589737_ChIP-Seq_MCF10A_Human1.19914593
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15948526
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13430994
81CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12780275
82CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.12512843
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11879429
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08517108
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08216308
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07277359
87TBX5_21415370_ChIP-Seq_HL-1_Mouse1.06541430
88SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05580009
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05255238
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05056786
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04868559
92PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04124777
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03774412
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03282262
95EGR1_19374776_ChIP-ChIP_THP-1_Human1.03133058
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02881339
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02793547
98P68_20966046_ChIP-Seq_HELA_Human1.00986254
99ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00862623
100CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00831629
101SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98202564
102SPI1_23547873_ChIP-Seq_NB4_Human0.97443764
103PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97082257
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96704987
105TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96301545
106PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95598486
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94322143
108CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93572985
109EED_16625203_ChIP-ChIP_MESCs_Mouse0.93502523
110REST_18959480_ChIP-ChIP_MESCs_Mouse0.93199355
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92388217
112ELF1_20517297_ChIP-Seq_JURKAT_Human0.91195799
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90832385
114CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90334046
115SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.88734011
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88389593
117FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87258486
118MYC_18940864_ChIP-ChIP_HL60_Human0.86590677
119EZH2_27304074_Chip-Seq_ESCs_Mouse0.84661502
120CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84526628
121VDR_21846776_ChIP-Seq_THP-1_Human0.84441321
122OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82434032
123TFEB_21752829_ChIP-Seq_HELA_Human0.80384377
124RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.77822172
125CTCF_18555785_ChIP-Seq_MESCs_Mouse0.77025146
126STAT3_1855785_ChIP-Seq_MESCs_Mouse0.75068714
127NANOG_21062744_ChIP-ChIP_HESCs_Human0.73696067
128TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.71094159
129IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.70062261

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.70521486
2MP0010094_abnormal_chromosome_stability4.23063047
3MP0003111_abnormal_nucleus_morphology3.85849687
4MP0004957_abnormal_blastocyst_morpholog3.66178619
5MP0003077_abnormal_cell_cycle3.44595649
6MP0008058_abnormal_DNA_repair3.08882127
7MP0002396_abnormal_hematopoietic_system3.07886211
8MP0008057_abnormal_DNA_replication2.79509149
9MP0008007_abnormal_cellular_replicative2.73692913
10MP0003123_paternal_imprinting2.56008981
11MP0003786_premature_aging2.46552381
12MP0004859_abnormal_synaptic_plasticity2.37287991
13MP0003763_abnormal_thymus_physiology2.19923946
14MP0008932_abnormal_embryonic_tissue2.15490764
15MP0005623_abnormal_meninges_morphology2.07539548
16MP0002234_abnormal_pharynx_morphology2.05944728
17MP0003880_abnormal_central_pattern2.04053168
18MP0008877_abnormal_DNA_methylation1.98932975
19MP0004808_abnormal_hematopoietic_stem1.89300771
20MP0000490_abnormal_crypts_of1.74283956
21MP0009333_abnormal_splenocyte_physiolog1.73667164
22MP0004270_analgesia1.72984619
23MP0005499_abnormal_olfactory_system1.71323208
24MP0005394_taste/olfaction_phenotype1.71323208
25MP0000350_abnormal_cell_proliferation1.70009595
26MP0002249_abnormal_larynx_morphology1.69231113
27MP0003121_genomic_imprinting1.62966734
28MP0001730_embryonic_growth_arrest1.61491609
29MP0000778_abnormal_nervous_system1.61019939
30MP0002822_catalepsy1.59428642
31MP0003385_abnormal_body_wall1.56894444
32MP0003315_abnormal_perineum_morphology1.49140810
33MP0002160_abnormal_reproductive_system1.48275837
34MP0000703_abnormal_thymus_morphology1.46401205
35MP0006276_abnormal_autonomic_nervous1.41671538
36MP0002132_abnormal_respiratory_system1.38898693
37MP0003937_abnormal_limbs/digits/tail_de1.37946853
38MP0003635_abnormal_synaptic_transmissio1.37579084
39MP0001346_abnormal_lacrimal_gland1.36222176
40MP0005187_abnormal_penis_morphology1.36116950
41MP0003122_maternal_imprinting1.35066411
42MP0002210_abnormal_sex_determination1.35031489
43MP0010030_abnormal_orbit_morphology1.34941034
44MP0002398_abnormal_bone_marrow1.34596200
45MP0006292_abnormal_olfactory_placode1.33281887
46MP0003718_maternal_effect1.32993608
47MP0008260_abnormal_autophagy1.32416307
48MP0000955_abnormal_spinal_cord1.31906489
49MP0005671_abnormal_response_to1.30069268
50MP0008995_early_reproductive_senescence1.29423112
51MP0003567_abnormal_fetal_cardiomyocyte1.29078523
52MP0002102_abnormal_ear_morphology1.25972758
53MP0000313_abnormal_cell_death1.25202442
54MP0009046_muscle_twitch1.24959745
55MP0004811_abnormal_neuron_physiology1.24940558
56MP0002063_abnormal_learning/memory/cond1.24930791
57MP0005397_hematopoietic_system_phenotyp1.23987046
58MP0001545_abnormal_hematopoietic_system1.23987046
59MP0002080_prenatal_lethality1.22678609
60MP0000678_abnormal_parathyroid_gland1.22460427
61MP0003861_abnormal_nervous_system1.22417530
62MP0005377_hearing/vestibular/ear_phenot1.21162376
63MP0003878_abnormal_ear_physiology1.21162376
64MP0002019_abnormal_tumor_incidence1.21064737
65MP0002697_abnormal_eye_size1.20724203
66MP0002722_abnormal_immune_system1.19555624
67MP0001672_abnormal_embryogenesis/_devel1.19475366
68MP0005380_embryogenesis_phenotype1.19475366
69MP0000566_synostosis1.19377987
70MP0002233_abnormal_nose_morphology1.17050454
71MP0001697_abnormal_embryo_size1.16411833
72MP0002736_abnormal_nociception_after1.16162299
73MP0001145_abnormal_male_reproductive1.13156604
74MP0002095_abnormal_skin_pigmentation1.12678227
75MP0001299_abnormal_eye_distance/1.12353199
76MP0003984_embryonic_growth_retardation1.10341734
77MP0005075_abnormal_melanosome_morpholog1.09981178
78MP0001968_abnormal_touch/_nociception1.09671808
79MP0003119_abnormal_digestive_system1.09552075
80MP0002064_seizures1.09213166
81MP0003186_abnormal_redox_activity1.08758186
82MP0009745_abnormal_behavioral_response1.07186275
83MP0004133_heterotaxia1.06921122
84MP0001929_abnormal_gametogenesis1.06853585
85MP0005645_abnormal_hypothalamus_physiol1.06578697
86MP0002088_abnormal_embryonic_growth/wei1.06430699
87MP0001984_abnormal_olfaction1.05829246
88MP0002184_abnormal_innervation1.05630848
89MP0002557_abnormal_social/conspecific_i1.05468059
90MP0002734_abnormal_mechanical_nocicepti1.04850518
91MP0005423_abnormal_somatic_nervous1.04068444
92MP0003938_abnormal_ear_development1.03708806
93MP0009053_abnormal_anal_canal1.03017145
94MP0002572_abnormal_emotion/affect_behav1.02545476
95MP0000689_abnormal_spleen_morphology1.02186636
96MP0002938_white_spotting1.02158738
97MP0006036_abnormal_mitochondrial_physio1.01325372
98MP0003755_abnormal_palate_morphology0.99589089
99MP0002085_abnormal_embryonic_tissue0.98773403
100MP0002152_abnormal_brain_morphology0.98502137
101MP0006054_spinal_hemorrhage0.98424126
102MP0002653_abnormal_ependyma_morphology0.97851715
103MP0002882_abnormal_neuron_morphology0.96831082
104MP0000631_abnormal_neuroendocrine_gland0.96520632
105MP0002429_abnormal_blood_cell0.94584503
106MP0005389_reproductive_system_phenotype0.94562383
107MP0001905_abnormal_dopamine_level0.94108881
108MP0001270_distended_abdomen0.92198182
109MP0000537_abnormal_urethra_morphology0.92135672
110MP0004084_abnormal_cardiac_muscle0.91212232
111MP0000653_abnormal_sex_gland0.91101513
112MP0000372_irregular_coat_pigmentation0.90119817
113MP0009379_abnormal_foot_pigmentation0.88528047
114MP0003221_abnormal_cardiomyocyte_apopto0.87599257
115MP0002272_abnormal_nervous_system0.87557391
116MP0000716_abnormal_immune_system0.86110017
117MP0003941_abnormal_skin_development0.85675488
118MP0000465_gastrointestinal_hemorrhage0.84757967
119MP0000534_abnormal_ureter_morphology0.84756533
120MP0005379_endocrine/exocrine_gland_phen0.84581002
121MP0002752_abnormal_somatic_nervous0.83641887
122MP0003329_amyloid_beta_deposits0.82235712
123MP0002092_abnormal_eye_morphology0.82195983
124MP0002086_abnormal_extraembryonic_tissu0.81447322
125MP0003698_abnormal_male_reproductive0.81172429
126MP0002420_abnormal_adaptive_immunity0.80123962
127MP0002733_abnormal_thermal_nociception0.79850400
128MP0003283_abnormal_digestive_organ0.79819765
129MP0002084_abnormal_developmental_patter0.79714282
130MP0001486_abnormal_startle_reflex0.79570082
131MP0009250_abnormal_appendicular_skeleto0.79543400
132MP0004233_abnormal_muscle_weight0.78488609
133MP0004858_abnormal_nervous_system0.78362263
134MP0003942_abnormal_urinary_system0.77367909
135MP0001819_abnormal_immune_cell0.76647042
136MP0002751_abnormal_autonomic_nervous0.76368498
137MP0002089_abnormal_postnatal_growth/wei0.75684390
138MP0000049_abnormal_middle_ear0.75482864
139MP0009278_abnormal_bone_marrow0.75434393
140MP0010307_abnormal_tumor_latency0.74906404
141MP0002163_abnormal_gland_morphology0.74380747
142MP0001542_abnormal_bone_strength0.74278648
143MP0005174_abnormal_tail_pigmentation0.73962952
144MP0000750_abnormal_muscle_regeneration0.73520116
145MP0001529_abnormal_vocalization0.73093796
146MP0000358_abnormal_cell_content/0.72244474
147MP0001873_stomach_inflammation0.71782934
148MP0004197_abnormal_fetal_growth/weight/0.71301392
149MP0000015_abnormal_ear_pigmentation0.70191000
150MP0001986_abnormal_taste_sensitivity0.69964463
151MP0001119_abnormal_female_reproductive0.69527579
152MP0008789_abnormal_olfactory_epithelium0.68525111
153MP0003136_yellow_coat_color0.66834738
154MP0001293_anophthalmia0.66465811
155MP0000428_abnormal_craniofacial_morphol0.66010693
156MP0001188_hyperpigmentation0.64317681
157MP0005410_abnormal_fertilization0.63538874
158MP0000681_abnormal_thyroid_gland0.62925926
159MP0000858_altered_metastatic_potential0.62895417
160MP0005384_cellular_phenotype0.62005070
161MP0006035_abnormal_mitochondrial_morpho0.61730914
162MP0003866_abnormal_defecation0.61115917

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.59666892
2Abnormality of cells of the erythroid lineage (HP:0012130)3.81678899
3Reticulocytopenia (HP:0001896)3.80291976
4Aplastic anemia (HP:0001915)3.72771911
5Abnormal number of erythroid precursors (HP:0012131)3.66176876
6Abnormal mitochondria in muscle tissue (HP:0008316)3.38258329
7Cerebral hypomyelination (HP:0006808)3.24332672
8Degeneration of anterior horn cells (HP:0002398)3.23648308
9Abnormality of the anterior horn cell (HP:0006802)3.23648308
10Acute necrotizing encephalopathy (HP:0006965)3.18405570
11Colon cancer (HP:0003003)3.17452430
12Rough bone trabeculation (HP:0100670)3.16575185
13Breast hypoplasia (HP:0003187)3.11980785
14Selective tooth agenesis (HP:0001592)2.97814391
15Abnormality of glycolysis (HP:0004366)2.97654412
16Microretrognathia (HP:0000308)2.93706677
17Patellar aplasia (HP:0006443)2.93652537
18Acute encephalopathy (HP:0006846)2.89752644
19Myokymia (HP:0002411)2.85355684
20Aplasia/Hypoplasia of the patella (HP:0006498)2.81974446
21Increased serum pyruvate (HP:0003542)2.81613911
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.77804896
23Abnormality of the preputium (HP:0100587)2.76188575
2411 pairs of ribs (HP:0000878)2.74890068
25Premature graying of hair (HP:0002216)2.74752126
26Chromsome breakage (HP:0040012)2.74039334
27Meckel diverticulum (HP:0002245)2.70883967
28Abnormality of the ileum (HP:0001549)2.66390126
29Broad distal phalanx of finger (HP:0009836)2.62360197
30Glossoptosis (HP:0000162)2.60158565
31Oral leukoplakia (HP:0002745)2.53406261
32Decreased activity of mitochondrial respiratory chain (HP:0008972)2.52551899
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.52551899
34Retinal dysplasia (HP:0007973)2.52318623
35Impulsivity (HP:0100710)2.51973351
36Macrocytic anemia (HP:0001972)2.49068548
37Absent thumb (HP:0009777)2.46514317
38Testicular atrophy (HP:0000029)2.45038581
39High anterior hairline (HP:0009890)2.42668532
40Abnormality of the lower motor neuron (HP:0002366)2.42113209
41Atrophy/Degeneration involving motor neurons (HP:0007373)2.40554882
42Type I transferrin isoform profile (HP:0003642)2.37802994
43Pallor (HP:0000980)2.35121847
44Myelodysplasia (HP:0002863)2.35112416
45Insomnia (HP:0100785)2.34583362
46IgM deficiency (HP:0002850)2.34325642
47Mitochondrial inheritance (HP:0001427)2.29386517
48Abnormality of the umbilical cord (HP:0010881)2.29253191
49Progressive macrocephaly (HP:0004481)2.27848656
50Bone marrow hypocellularity (HP:0005528)2.27624438
51Abnormality of the aortic arch (HP:0012303)2.25446879
52Small intestinal stenosis (HP:0012848)2.25160264
53Duodenal stenosis (HP:0100867)2.25160264
54Astrocytoma (HP:0009592)2.24972026
55Abnormality of the astrocytes (HP:0100707)2.24972026
56Abnormal lung lobation (HP:0002101)2.24865560
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.23810766
58Amblyopia (HP:0000646)2.22928609
59Carpal bone hypoplasia (HP:0001498)2.22883377
60Abnormality of chromosome stability (HP:0003220)2.20618071
61Increased CSF lactate (HP:0002490)2.19677085
62Ragged-red muscle fibers (HP:0003200)2.19312256
63Muscle fiber atrophy (HP:0100295)2.16271843
64Type 2 muscle fiber atrophy (HP:0003554)2.16202882
65Hyperacusis (HP:0010780)2.15596789
66Increased serum lactate (HP:0002151)2.14810158
67Multiple enchondromatosis (HP:0005701)2.13819570
68Abnormal trabecular bone morphology (HP:0100671)2.13405189
69Hepatocellular necrosis (HP:0001404)2.11042366
70Premature ovarian failure (HP:0008209)2.10415138
71Cerebral edema (HP:0002181)2.09515136
72Aplasia/Hypoplasia of the sternum (HP:0006714)2.09194935
73Facial cleft (HP:0002006)2.08947583
74Overriding aorta (HP:0002623)2.08791938
75Hypoplasia of the capital femoral epiphysis (HP:0003090)2.07927851
76Cortical dysplasia (HP:0002539)2.07108006
77Congenital malformation of the right heart (HP:0011723)2.06362291
78Double outlet right ventricle (HP:0001719)2.06362291
79Occipital encephalocele (HP:0002085)2.05947906
80Slender long bone (HP:0003100)2.04566863
81Entropion (HP:0000621)2.03759179
82Neoplasm of the pancreas (HP:0002894)2.03135221
83Trismus (HP:0000211)2.02215581
84Cleft eyelid (HP:0000625)2.01293156
85Irregular epiphyses (HP:0010582)2.01044793
86Atresia of the external auditory canal (HP:0000413)2.01010946
87Elfin facies (HP:0004428)2.00935029
88Lactic acidosis (HP:0003128)2.00647396
89Pancytopenia (HP:0001876)1.98941927
90Abnormal number of incisors (HP:0011064)1.98152425
91Hyperglycinemia (HP:0002154)1.95451220
92Thrombocytosis (HP:0001894)1.94382906
93Abnormality of the fetal cardiovascular system (HP:0010948)1.94153004
94Abnormal umbilical cord blood vessels (HP:0011403)1.94153004
95Single umbilical artery (HP:0001195)1.94153004
96Hepatic necrosis (HP:0002605)1.94108652
97Spastic diplegia (HP:0001264)1.89388769
98IgG deficiency (HP:0004315)1.88501924
99Truncus arteriosus (HP:0001660)1.88163370
100Petechiae (HP:0000967)1.87092137
101Lymphoma (HP:0002665)1.86582568
102Abnormality of the labia minora (HP:0012880)1.86431993
103Cellular immunodeficiency (HP:0005374)1.85711019
104Sparse eyelashes (HP:0000653)1.85000486
105Secondary amenorrhea (HP:0000869)1.84809558
1063-Methylglutaconic aciduria (HP:0003535)1.84545943
107Patent foramen ovale (HP:0001655)1.82822071
108Triphalangeal thumb (HP:0001199)1.82533876
109Transposition of the great arteries (HP:0001669)1.82451012
110Abnormal connection of the cardiac segments (HP:0011545)1.82451012
111Abnormal ventriculo-arterial connection (HP:0011563)1.82451012
112Lissencephaly (HP:0001339)1.81324447
113Abnormal spermatogenesis (HP:0008669)1.81298597
114Gout (HP:0001997)1.80728027
115Type II lissencephaly (HP:0007260)1.79265740
116Sloping forehead (HP:0000340)1.79128083
117Short middle phalanx of the 5th finger (HP:0004220)1.78326059
118Exercise intolerance (HP:0003546)1.76659023
119Abnormality of the distal phalanges of the toes (HP:0010182)1.75934627
120Spinal muscular atrophy (HP:0007269)1.75545204
121Optic nerve coloboma (HP:0000588)1.74861328
122Aplasia/Hypoplasia of the brainstem (HP:0007362)1.74856390
123Hypoplasia of the brainstem (HP:0002365)1.74856390
124Tracheoesophageal fistula (HP:0002575)1.74655447
125Absent epiphyses (HP:0010577)1.74327154
126Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.74327154
127Opisthotonus (HP:0002179)1.74231801
128CNS hypomyelination (HP:0003429)1.73902727
129Preaxial hand polydactyly (HP:0001177)1.73092728
130Hypoplasia of the radius (HP:0002984)1.71512052
131Horseshoe kidney (HP:0000085)1.70822175
132Posterior embryotoxon (HP:0000627)1.70463753
133Medulloblastoma (HP:0002885)1.69143063
134Pancreatic fibrosis (HP:0100732)1.68909790
135Hypoplasia of the pons (HP:0012110)1.68581492
136Renal duplication (HP:0000075)1.68441786
137Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68051150
138Abnormality of alanine metabolism (HP:0010916)1.68051150
139Hyperalaninemia (HP:0003348)1.68051150
140Ureteral duplication (HP:0000073)1.67077717
141Basal cell carcinoma (HP:0002671)1.66172526
142Redundant skin (HP:0001582)1.65843289
143Shoulder girdle muscle weakness (HP:0003547)1.65771767
144Sclerocornea (HP:0000647)1.65497529
145Microvesicular hepatic steatosis (HP:0001414)1.65208207
146Ependymoma (HP:0002888)1.64319461
147Abnormality of the carotid arteries (HP:0005344)1.62875259
148Pulmonary fibrosis (HP:0002206)1.62627779
149Abnormality of the duodenum (HP:0002246)1.62434859
150True hermaphroditism (HP:0010459)1.62159942
151Proximal placement of thumb (HP:0009623)1.61915282
152Short thumb (HP:0009778)1.61401031
153Unsteady gait (HP:0002317)1.60842069
154Progressive muscle weakness (HP:0003323)1.60616511
155Broad alveolar ridges (HP:0000187)1.60024324
156Emotional lability (HP:0000712)1.59909512
157Abnormality of DNA repair (HP:0003254)1.59669140
158Nephroblastoma (Wilms tumor) (HP:0002667)1.58701289
159Increased nuchal translucency (HP:0010880)1.58620459
160Aplasia/Hypoplasia of the sacrum (HP:0008517)1.58230759
161Ankle contracture (HP:0006466)1.58052598
162Abnormality of the phalanges of the hallux (HP:0010057)1.57926531
163Renal dysplasia (HP:0000110)1.57621687
164Unilateral renal agenesis (HP:0000122)1.57484271
165Absent radius (HP:0003974)1.56281698
166Cerebellar hypoplasia (HP:0001321)1.54552110
167Increased intramyocellular lipid droplets (HP:0012240)1.53573990
168Abnormality of the line of Schwalbe (HP:0008048)1.52590798
169Glioma (HP:0009733)1.51807570
170Leukodystrophy (HP:0002415)1.51214093
171Poor suck (HP:0002033)1.50081244
172Renovascular hypertension (HP:0100817)1.49047098
173Severe muscular hypotonia (HP:0006829)1.47758267
174Limb dystonia (HP:0002451)1.47594604
175Gait imbalance (HP:0002141)1.47162992
176Pachygyria (HP:0001302)1.46282974
177Abnormality of cochlea (HP:0000375)1.44759653
178Cutaneous melanoma (HP:0012056)1.43619536

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.01756499
2WEE13.97959528
3TSSK63.34778140
4STK163.24166183
5NME23.13421499
6CDC73.00976203
7ACVR1B2.86145887
8MAP2K72.69438178
9CCNB12.65825942
10BCKDK2.47842499
11SRPK12.32174733
12MKNK12.26961802
13VRK12.25282690
14EPHA42.20449620
15CSNK1A1L2.11862815
16MARK12.08963658
17NEK22.07278262
18EIF2AK12.05384465
19PIM21.99864753
20MAP3K41.96561659
21DYRK31.91903835
22TESK21.91540553
23CSNK1G21.90418576
24NEK11.84007419
25VRK21.83961139
26MKNK21.80416543
27PLK41.79670293
28CSNK1G11.73009373
29BCR1.67750687
30BRSK11.66614799
31PLK11.65597238
32PRKD31.65009999
33PASK1.60525250
34PLK31.58818766
35BRSK21.56145597
36MAP4K11.56055267
37RPS6KA41.51245413
38PAK61.43874929
39ATR1.43726997
40EIF2AK31.42753232
41CDK71.38772204
42TXK1.38412730
43TGFBR11.31412685
44TRIM281.25002293
45ICK1.24357771
46AURKB1.23599811
47MAP3K121.23271158
48MINK11.22884515
49TESK11.17911048
50AKT31.16727387
51ZAK1.13328395
52CDK141.08852432
53CDK11A1.08012698
54BRAF1.07716814
55EPHB21.04768992
56MAP4K21.04445013
57IRAK31.04159472
58SMG11.03303452
59CDK181.02925649
60CDK151.02918520
61RPS6KB21.00545421
62ILK0.97959879
63ARAF0.97611542
64CDK80.95499771
65TTK0.94458248
66PBK0.94110254
67TLK10.91306633
68MAP2K40.88145202
69NME10.87666006
70PAK40.87105469
71CHEK20.86760638
72ZAP700.86581421
73WNK30.85789208
74TEC0.85203344
75KDR0.80468403
76PINK10.79865623
77AKT20.79419904
78NTRK10.78868853
79ABL20.77137358
80DAPK10.76940969
81AURKA0.76714224
82EEF2K0.76462931
83CHEK10.75698602
84CDK40.75144457
85TRIB30.74855327
86PRKCI0.72675157
87PDK30.72466125
88PDK40.72466125
89SIK30.72007372
90DYRK1B0.71082600
91BTK0.70857078
92SIK20.69105152
93RAF10.67300298
94BRD40.66274109
95PAK10.66065863
96UHMK10.65259002
97LRRK20.64689982
98PKN10.64686424
99PLK20.64274996
100TAOK20.63610065
101NTRK20.62444574
102CDK190.60646999
103CAMK1D0.60322137
104CSNK2A10.59925116
105CAMK1G0.58619072
106MAP3K80.56443244
107CDK20.56302865
108CDK50.56203423
109LMTK20.55766709
110PIM10.55649508
111CSNK1E0.54510270
112ERBB30.52805939
113MYLK0.52533362
114CSNK2A20.52088921
115PRKCG0.50865503
116CAMK40.50430557
117SCYL20.49322920
118MAPKAPK50.48656665
119PIK3CG0.48163753
120STK240.46864272
121RPS6KA50.46563482
122PDK20.44647648
123EIF2AK20.44201288
124CASK0.43817646
125ATM0.41849245
126MAP3K110.41534293
127LIMK10.41473501
128CDK10.40770360
129DAPK30.40375190
130IRAK20.39847548
131CAMK2G0.39642529
132KIT0.39511925
133RPS6KA60.37456506
134CLK10.34939827
135CAMKK20.34749912
136RPS6KC10.34216642
137RPS6KL10.34216642
138SYK0.32484207
139MAPK130.32281712
140ALK0.31741568
141MAPKAPK30.26591999
142STK100.26475906
143CSNK1G30.22574159
144CSF1R0.22016490
145MAP2K30.21111962
146STK40.20269538
147DYRK20.19793641
148ITK0.19760659

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.60861174
2Ribosome_Homo sapiens_hsa030103.78692580
3Mismatch repair_Homo sapiens_hsa034303.73352742
4RNA polymerase_Homo sapiens_hsa030203.63661275
5Proteasome_Homo sapiens_hsa030503.60079022
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.37262900
7Base excision repair_Homo sapiens_hsa034103.17998139
8Spliceosome_Homo sapiens_hsa030403.12432037
9RNA transport_Homo sapiens_hsa030132.79251594
10Homologous recombination_Homo sapiens_hsa034402.69153333
11Nucleotide excision repair_Homo sapiens_hsa034202.67691755
12* Pyrimidine metabolism_Homo sapiens_hsa002402.60074079
13Cell cycle_Homo sapiens_hsa041102.41475396
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.12854472
15Fanconi anemia pathway_Homo sapiens_hsa034601.93905953
16Basal transcription factors_Homo sapiens_hsa030221.77057461
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.76892891
18RNA degradation_Homo sapiens_hsa030181.76349233
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.68582663
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66631686
21* Purine metabolism_Homo sapiens_hsa002301.64383939
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63360998
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.61805706
24mRNA surveillance pathway_Homo sapiens_hsa030151.59672396
25Synaptic vesicle cycle_Homo sapiens_hsa047211.55920685
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55132312
27Non-homologous end-joining_Homo sapiens_hsa034501.52819045
28Selenocompound metabolism_Homo sapiens_hsa004501.51743438
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.51020888
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.44066848
31Fatty acid elongation_Homo sapiens_hsa000621.43084321
32Steroid biosynthesis_Homo sapiens_hsa001001.37907257
33Carbon metabolism_Homo sapiens_hsa012001.37556438
34p53 signaling pathway_Homo sapiens_hsa041151.34962041
35Pyruvate metabolism_Homo sapiens_hsa006201.34555699
36Vitamin B6 metabolism_Homo sapiens_hsa007501.31855408
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30624167
38Epstein-Barr virus infection_Homo sapiens_hsa051691.30507107
39Primary immunodeficiency_Homo sapiens_hsa053401.28907421
40Arginine and proline metabolism_Homo sapiens_hsa003301.28244677
41One carbon pool by folate_Homo sapiens_hsa006701.22979226
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19250127
43Vibrio cholerae infection_Homo sapiens_hsa051101.17400899
44Antigen processing and presentation_Homo sapiens_hsa046121.10972591
45Oocyte meiosis_Homo sapiens_hsa041141.02291318
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00831802
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98814947
48Regulation of autophagy_Homo sapiens_hsa041400.97593560
49Nicotine addiction_Homo sapiens_hsa050330.95038609
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89538497
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86208437
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86174143
53Sulfur metabolism_Homo sapiens_hsa009200.85630920
54HTLV-I infection_Homo sapiens_hsa051660.83233292
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82631034
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82506669
57Herpes simplex infection_Homo sapiens_hsa051680.81949364
58Cardiac muscle contraction_Homo sapiens_hsa042600.80395644
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77607191
60* Metabolic pathways_Homo sapiens_hsa011000.76608213
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75351609
62Propanoate metabolism_Homo sapiens_hsa006400.74178372
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74166902
64Huntingtons disease_Homo sapiens_hsa050160.71604461
65Viral carcinogenesis_Homo sapiens_hsa052030.69700986
66Parkinsons disease_Homo sapiens_hsa050120.67314149
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67138686
68Pentose phosphate pathway_Homo sapiens_hsa000300.65655647
69Arginine biosynthesis_Homo sapiens_hsa002200.65328829
70Protein export_Homo sapiens_hsa030600.63467039
71Collecting duct acid secretion_Homo sapiens_hsa049660.62926802
72Peroxisome_Homo sapiens_hsa041460.62785502
73N-Glycan biosynthesis_Homo sapiens_hsa005100.60988937
74Measles_Homo sapiens_hsa051620.60416987
75Legionellosis_Homo sapiens_hsa051340.58509148
76GABAergic synapse_Homo sapiens_hsa047270.57731886
77Colorectal cancer_Homo sapiens_hsa052100.55523090
78Fatty acid metabolism_Homo sapiens_hsa012120.55162921
79Axon guidance_Homo sapiens_hsa043600.53520952
80Phenylalanine metabolism_Homo sapiens_hsa003600.53290225
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51978462
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51118177
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.51015741
84T cell receptor signaling pathway_Homo sapiens_hsa046600.49465324
85beta-Alanine metabolism_Homo sapiens_hsa004100.48595200
86Dopaminergic synapse_Homo sapiens_hsa047280.46166212
87Cocaine addiction_Homo sapiens_hsa050300.46074829
88Thyroid cancer_Homo sapiens_hsa052160.45762844
89Butanoate metabolism_Homo sapiens_hsa006500.44290162
90Glutathione metabolism_Homo sapiens_hsa004800.43989931
91Hepatitis B_Homo sapiens_hsa051610.43349268
92Shigellosis_Homo sapiens_hsa051310.42760615
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42444187
94Systemic lupus erythematosus_Homo sapiens_hsa053220.42117679
95Phototransduction_Homo sapiens_hsa047440.42005981
96Fructose and mannose metabolism_Homo sapiens_hsa000510.41717601
97Alcoholism_Homo sapiens_hsa050340.39690934
98Hematopoietic cell lineage_Homo sapiens_hsa046400.38159787
99Fat digestion and absorption_Homo sapiens_hsa049750.38107236
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37646885
101Oxidative phosphorylation_Homo sapiens_hsa001900.36973868
102Lysine degradation_Homo sapiens_hsa003100.36311521
103AMPK signaling pathway_Homo sapiens_hsa041520.36171853
104Apoptosis_Homo sapiens_hsa042100.36169594
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35875907
106Folate biosynthesis_Homo sapiens_hsa007900.35598085
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.35278142
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.33776010
109Hippo signaling pathway_Homo sapiens_hsa043900.33227349
110Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33210834
111Morphine addiction_Homo sapiens_hsa050320.31946463
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31288833
113Tyrosine metabolism_Homo sapiens_hsa003500.31166156
114Small cell lung cancer_Homo sapiens_hsa052220.30873317
115Basal cell carcinoma_Homo sapiens_hsa052170.30791049
116Influenza A_Homo sapiens_hsa051640.30489482
117Hedgehog signaling pathway_Homo sapiens_hsa043400.28760343
118Graft-versus-host disease_Homo sapiens_hsa053320.28603471
119Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.28485759
120HIF-1 signaling pathway_Homo sapiens_hsa040660.27443818
121NF-kappa B signaling pathway_Homo sapiens_hsa040640.26296352
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26182353
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26116897
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26018830
125Acute myeloid leukemia_Homo sapiens_hsa052210.25813014
126Notch signaling pathway_Homo sapiens_hsa043300.24814681
127Pathways in cancer_Homo sapiens_hsa052000.24340604
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24332527
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24079311
130Circadian rhythm_Homo sapiens_hsa047100.23804481
131Non-small cell lung cancer_Homo sapiens_hsa052230.23074090
132Biosynthesis of amino acids_Homo sapiens_hsa012300.22975744
133Allograft rejection_Homo sapiens_hsa053300.22679065
134MicroRNAs in cancer_Homo sapiens_hsa052060.21959629
135Sulfur relay system_Homo sapiens_hsa041220.20898287
136Wnt signaling pathway_Homo sapiens_hsa043100.20377000
137Galactose metabolism_Homo sapiens_hsa000520.20097546
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18922096
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18880089
140Chronic myeloid leukemia_Homo sapiens_hsa052200.18635167
141Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18506212
142RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17146664
143Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16911500
144Endometrial cancer_Homo sapiens_hsa052130.16453437
145Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.15933586
146Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.15912864
147NOD-like receptor signaling pathway_Homo sapiens_hsa046210.15322398
148TGF-beta signaling pathway_Homo sapiens_hsa043500.13248021
149Autoimmune thyroid disease_Homo sapiens_hsa053200.13056693
150Neurotrophin signaling pathway_Homo sapiens_hsa047220.12750507
151Alzheimers disease_Homo sapiens_hsa050100.12191222
152Viral myocarditis_Homo sapiens_hsa054160.11623880

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