ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	7.42888044
2	gamma-aminobutyric acid transport (GO:0015812)	5.46357291
3	cell wall macromolecule catabolic process (GO:0016998)	5.12829078
4	cullin deneddylation (GO:0010388)	4.90645407
5	auditory behavior (GO:0031223)	4.64963530
6	respiratory chain complex IV assembly (GO:0008535)	4.60071133
7	mechanosensory behavior (GO:0007638)	4.51298393
8	protein deneddylation (GO:0000338)	4.48764862
9	cell wall macromolecule metabolic process (GO:0044036)	4.36802957
10	regulation of acrosome reaction (GO:0060046)	4.16457348
11	water-soluble vitamin biosynthetic process (GO:0042364)	3.80838815
12	protein-cofactor linkage (GO:0018065)	3.74692893
13	pyrimidine nucleobase catabolic process (GO:0006208)	3.73531816
14	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.70129721
15	mannosylation (GO:0097502)	3.61729985
16	retinal cone cell development (GO:0046549)	3.60341490
17	cytochrome complex assembly (GO:0017004)	3.50551930
18	nucleobase catabolic process (GO:0046113)	3.49023543
19	branched-chain amino acid catabolic process (GO:0009083)	3.35146029
20	presynaptic membrane assembly (GO:0097105)	3.29783131
21	DNA double-strand break processing (GO:0000729)	3.25485402
22	cellular ketone body metabolic process (GO:0046950)	3.24894737
23	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.19769950
24	xenobiotic catabolic process (GO:0042178)	3.19202510
25	vocalization behavior (GO:0071625)	3.17270687
26	neurotransmitter uptake (GO:0001504)	3.14891865
27	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.14554032
28	intraciliary transport (GO:0042073)	3.13248407
29	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	3.11443959
30	C-terminal protein amino acid modification (GO:0018410)	3.09889070
31	negative regulation of mast cell activation (GO:0033004)	3.08354710
32	proteasome assembly (GO:0043248)	3.06160036
33	GTP biosynthetic process (GO:0006183)	3.01041754
34	preassembly of GPI anchor in ER membrane (GO:0016254)	3.00688154
35	toxin transport (GO:1901998)	3.00496598
36	prenylation (GO:0097354)	2.95513100
37	protein prenylation (GO:0018342)	2.95513100
38	C-terminal protein lipidation (GO:0006501)	2.94950173
39	righting reflex (GO:0060013)	2.90306109
40	neuronal action potential (GO:0019228)	2.89699185
41	protein complex biogenesis (GO:0070271)	2.89645630
42	exocrine pancreas development (GO:0031017)	2.84649114
43	ketone body metabolic process (GO:1902224)	2.83279079
44	reflex (GO:0060004)	2.81814044
45	epithelial cilium movement (GO:0003351)	2.79722193
46	glyoxylate metabolic process (GO:0046487)	2.79215832
47	removal of superoxide radicals (GO:0019430)	2.79040927
48	cellular response to superoxide (GO:0071451)	2.79040927
49	cellular response to oxygen radical (GO:0071450)	2.79040927
50	carnitine transport (GO:0015879)	2.76013903
51	amino-acid betaine transport (GO:0015838)	2.76013903
52	positive regulation of meiotic cell cycle (GO:0051446)	2.75682248
53	regulation of meiosis I (GO:0060631)	2.73843645
54	low-density lipoprotein particle remodeling (GO:0034374)	2.73279841
55	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.71845081
56	DNA ligation (GO:0006266)	2.71151122
57	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.71014279
58	NADH dehydrogenase complex assembly (GO:0010257)	2.71014279
59	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.71014279
60	tachykinin receptor signaling pathway (GO:0007217)	2.70861842
61	L-serine transport (GO:0015825)	2.70438677
62	DNA integration (GO:0015074)	2.69792665
63	cholesterol biosynthetic process (GO:0006695)	2.68262459
64	regulation of timing of cell differentiation (GO:0048505)	2.68040578
65	DNA catabolic process, exonucleolytic (GO:0000738)	2.67615767
66	C4-dicarboxylate transport (GO:0015740)	2.66987836
67	positive regulation of meiosis (GO:0045836)	2.65512563
68	anterograde synaptic vesicle transport (GO:0048490)	2.65143136
69	regulation of mesoderm development (GO:2000380)	2.64367786
70	isoprenoid biosynthetic process (GO:0008299)	2.63903830
71	response to auditory stimulus (GO:0010996)	2.63001838
72	mitochondrial respiratory chain complex assembly (GO:0033108)	2.62632537
73	tyrosine phosphorylation of STAT protein (GO:0007260)	2.61345590
74	presynaptic membrane organization (GO:0097090)	2.57377112
75	adenosine metabolic process (GO:0046085)	2.56007270
76	interleukin-6-mediated signaling pathway (GO:0070102)	2.54030356
77	olfactory bulb development (GO:0021772)	2.51950736
78	sterol biosynthetic process (GO:0016126)	2.51131467
79	protein insertion into membrane (GO:0051205)	2.50746838
80	sleep (GO:0030431)	2.50591879
81	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.49416920
82	termination of RNA polymerase III transcription (GO:0006386)	2.49416920
83	alanine transport (GO:0032328)	2.49185188
84	indolalkylamine metabolic process (GO:0006586)	2.47866648
85	detection of calcium ion (GO:0005513)	2.47595907
86	regulation of action potential (GO:0098900)	2.47178829
87	electron transport chain (GO:0022900)	2.46686454
88	aldehyde catabolic process (GO:0046185)	2.46494311
89	carnitine transmembrane transport (GO:1902603)	2.46136920
90	respiratory electron transport chain (GO:0022904)	2.45303172
91	serotonin metabolic process (GO:0042428)	2.42561556
92	protein localization to cilium (GO:0061512)	2.42245264
93	endoderm formation (GO:0001706)	2.41818790
94	inositol phosphate catabolic process (GO:0071545)	2.39836492
95	branched-chain amino acid metabolic process (GO:0009081)	2.39478342
96	UTP metabolic process (GO:0046051)	2.39363622
97	response to superoxide (GO:0000303)	2.39227459
98	glycosphingolipid biosynthetic process (GO:0006688)	2.38922051
99	neuron cell-cell adhesion (GO:0007158)	2.38053892
100	negative regulation of activin receptor signaling pathway (GO:0032926)	2.37698875

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.73411590
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.71454588
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.62363132
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.46486987
5	IGF1R_20145208_ChIP-Seq_DFB_Human	3.08600998
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.86299418
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.78364157
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.74734166
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.62034688
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.48199478
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.40325989
12	FUS_26573619_Chip-Seq_HEK293_Human	2.36568127
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.34946437
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.27909026
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.26087452
16	EWS_26573619_Chip-Seq_HEK293_Human	2.22207630
17	VDR_22108803_ChIP-Seq_LS180_Human	2.21328438
18	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.19431255
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.04250966
20	P300_19829295_ChIP-Seq_ESCs_Human	2.02952334
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.02052907
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.97639177
23	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.96049588
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.93467177
25	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.88459595
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.84745409
27	BCAT_22108803_ChIP-Seq_LS180_Human	1.78810297
28	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.71382626
29	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.69081051
30	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.66347653
31	SMAD4_21799915_ChIP-Seq_A2780_Human	1.55115323
32	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.53080152
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.53080152
34	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.50602542
35	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.48586472
36	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.46571160
37	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.45912712
38	TCF4_22108803_ChIP-Seq_LS180_Human	1.45833070
39	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.45126380
40	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.44276485
41	VDR_23849224_ChIP-Seq_CD4+_Human	1.44052298
42	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.42724018
43	AR_25329375_ChIP-Seq_VCAP_Human	1.40210482
44	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.39806759
45	ELK1_19687146_ChIP-ChIP_HELA_Human	1.38417906
46	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.37427102
47	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37367369
48	TCF4_23295773_ChIP-Seq_U87_Human	1.36076855
49	STAT3_23295773_ChIP-Seq_U87_Human	1.34750014
50	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.34515306
51	SOX2_19829295_ChIP-Seq_ESCs_Human	1.34260144
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.34260144
53	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.31621848
54	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.29591600
55	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.29426399
56	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.28144852
57	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27851796
58	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.26416846
59	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.23431291
60	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.23135420
61	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.23005170
62	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.21563828
63	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.21310178
64	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.18746552
65	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.17909965
66	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.15941856
67	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15941856
68	TP53_22573176_ChIP-Seq_HFKS_Human	1.15913842
69	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.14413916
70	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10440496
71	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.10163269
72	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.09179198
73	RUNX2_22187159_ChIP-Seq_PCA_Human	1.07225175
74	HTT_18923047_ChIP-ChIP_STHdh_Human	1.03936283
75	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.03786662
76	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.03073186
77	FOXP3_21729870_ChIP-Seq_TREG_Human	1.02340620
78	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.02015390
79	EZH2_22144423_ChIP-Seq_EOC_Human	1.01118072
80	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.00905461
81	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.00287856
82	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.99654960
83	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.99583004
84	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.99163089
85	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.98936116
86	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.98727539
87	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.98727539
88	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.98722723
89	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.97427086
90	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.97230718
91	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.96672750
92	NCOR_22424771_ChIP-Seq_293T_Human	0.96665564
93	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.96560258
94	RNF2_27304074_Chip-Seq_NSC_Mouse	0.95452985
95	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94701867
96	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94563160
97	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.92079832
98	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.91653362
99	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.91545063
100	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.91285029

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000372_irregular_coat_pigmentation	3.37617726
2	MP0003890_abnormal_embryonic-extraembry	3.21633038
3	MP0002736_abnormal_nociception_after	3.16636244
4	MP0005360_urolithiasis	3.13405896
5	MP0003195_calcinosis	2.94147370
6	MP0001986_abnormal_taste_sensitivity	2.82628950
7	MP0001968_abnormal_touch/_nociception	2.66536877
8	MP0004147_increased_porphyrin_level	2.54401116
9	MP0003880_abnormal_central_pattern	2.53489200
10	MP0003787_abnormal_imprinting	2.46001306
11	MP0000427_abnormal_hair_cycle	2.34952050
12	MP0008877_abnormal_DNA_methylation	2.32201565
13	MP0002102_abnormal_ear_morphology	2.31193569
14	MP0008058_abnormal_DNA_repair	2.28523149
15	MP0005423_abnormal_somatic_nervous	2.18171132
16	MP0006276_abnormal_autonomic_nervous	2.12893306
17	MP0003011_delayed_dark_adaptation	2.02723043
18	MP0006054_spinal_hemorrhage	1.96241512
19	MP0000647_abnormal_sebaceous_gland	1.86813303
20	MP0009745_abnormal_behavioral_response	1.81653185
21	MP0001764_abnormal_homeostasis	1.79489441
22	MP0000516_abnormal_urinary_system	1.78900118
23	MP0005367_renal/urinary_system_phenotyp	1.78900118
24	MP0009046_muscle_twitch	1.77180690
25	MP0003806_abnormal_nucleotide_metabolis	1.76950230
26	MP0004859_abnormal_synaptic_plasticity	1.72506037
27	MP0004270_analgesia	1.72094233
28	MP0005084_abnormal_gallbladder_morpholo	1.69883426
29	MP0005551_abnormal_eye_electrophysiolog	1.66599666
30	MP0001529_abnormal_vocalization	1.65924543
31	MP0008875_abnormal_xenobiotic_pharmacok	1.63718533
32	MP0003646_muscle_fatigue	1.57395460
33	MP0002272_abnormal_nervous_system	1.54111766
34	MP0001501_abnormal_sleep_pattern	1.52705020
35	MP0005187_abnormal_penis_morphology	1.48779994
36	MP0004233_abnormal_muscle_weight	1.41204950
37	MP0005266_abnormal_metabolism	1.37458763
38	MP0005075_abnormal_melanosome_morpholog	1.32486801
39	MP0000569_abnormal_digit_pigmentation	1.32131558
40	MP0003635_abnormal_synaptic_transmissio	1.32015681
41	MP0002734_abnormal_mechanical_nocicepti	1.26486781
42	MP0002557_abnormal_social/conspecific_i	1.25014253
43	MP0010094_abnormal_chromosome_stability	1.21616815
44	MP0004133_heterotaxia	1.20152137
45	MP0003121_genomic_imprinting	1.19283817
46	MP0005646_abnormal_pituitary_gland	1.19100313
47	MP0009840_abnormal_foam_cell	1.17461613
48	MP0006072_abnormal_retinal_apoptosis	1.16863116
49	MP0002928_abnormal_bile_duct	1.15997472
50	MP0002090_abnormal_vision	1.15662924
51	MP0002160_abnormal_reproductive_system	1.14435866
52	MP0008872_abnormal_physiological_respon	1.14178527
53	MP0005636_abnormal_mineral_homeostasis	1.13737960
54	MP0003718_maternal_effect	1.10968809
55	MP0003119_abnormal_digestive_system	1.09233282
56	MP0002572_abnormal_emotion/affect_behav	1.08912160
57	MP0002332_abnormal_exercise_endurance	1.08323239
58	MP0002876_abnormal_thyroid_physiology	1.07255317
59	MP0001905_abnormal_dopamine_level	1.06672978
60	MP0004215_abnormal_myocardial_fiber	1.05903709
61	MP0001502_abnormal_circadian_rhythm	1.04728287
62	MP0003786_premature_aging	1.03655827
63	MP0005389_reproductive_system_phenotype	1.00157438
64	MP0005253_abnormal_eye_physiology	0.99048686
65	MP0001970_abnormal_pain_threshold	0.98559971
66	MP0005220_abnormal_exocrine_pancreas	0.98449337
67	MP0002067_abnormal_sensory_capabilities	0.94256548
68	MP0006036_abnormal_mitochondrial_physio	0.93677977
69	MP0009780_abnormal_chondrocyte_physiolo	0.93529575
70	MP0002063_abnormal_learning/memory/cond	0.93387474
71	MP0002254_reproductive_system_inflammat	0.93081622
72	MP0002735_abnormal_chemical_nociception	0.92841521
73	MP0005376_homeostasis/metabolism_phenot	0.92662421
74	MP0002064_seizures	0.91739240
75	MP0003186_abnormal_redox_activity	0.91320657
76	MP0005248_abnormal_Harderian_gland	0.90795286
77	MP0002638_abnormal_pupillary_reflex	0.89310738
78	MP0001346_abnormal_lacrimal_gland	0.85297178
79	MP0005174_abnormal_tail_pigmentation	0.84739330
80	MP0001944_abnormal_pancreas_morphology	0.84237250
81	MP0008789_abnormal_olfactory_epithelium	0.83464150
82	MP0001929_abnormal_gametogenesis	0.82673927
83	MP0010352_gastrointestinal_tract_polyps	0.81563550
84	MP0003136_yellow_coat_color	0.80586740
85	MP0008775_abnormal_heart_ventricle	0.80516501
86	MP0010386_abnormal_urinary_bladder	0.79442217
87	MP0005410_abnormal_fertilization	0.74325206
88	MP0003943_abnormal_hepatobiliary_system	0.73282843
89	MP0002733_abnormal_thermal_nociception	0.72943524
90	MP0002909_abnormal_adrenal_gland	0.72663762
91	MP0003137_abnormal_impulse_conducting	0.71488078
92	MP0006292_abnormal_olfactory_placode	0.70491997
93	MP0003633_abnormal_nervous_system	0.70458134
94	MP0002098_abnormal_vibrissa_morphology	0.70273692
95	MP0006035_abnormal_mitochondrial_morpho	0.70264798
96	MP0001486_abnormal_startle_reflex	0.69865169
97	MP0002837_dystrophic_cardiac_calcinosis	0.69756046
98	MP0004885_abnormal_endolymph	0.67704931
99	MP0005499_abnormal_olfactory_system	0.67071762
100	MP0005394_taste/olfaction_phenotype	0.67071762

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic fibrosis (HP:0100732)	3.94579476
2	Hyperventilation (HP:0002883)	3.70218550
3	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.61091693
4	Short tibia (HP:0005736)	3.38724096
5	Pancreatic cysts (HP:0001737)	3.38546318
6	Abnormal biliary tract physiology (HP:0012439)	3.16695647
7	Bile duct proliferation (HP:0001408)	3.16695647
8	Metaphyseal dysplasia (HP:0100255)	3.13943623
9	Aplasia/Hypoplasia of the tongue (HP:0010295)	3.11268954
10	Neoplasm of the adrenal gland (HP:0100631)	3.11231125
11	Upper limb muscle weakness (HP:0003484)	2.91346053
12	Acute necrotizing encephalopathy (HP:0006965)	2.85458949
13	Progressive macrocephaly (HP:0004481)	2.81602279
14	Ketoacidosis (HP:0001993)	2.79193692
15	Chronic hepatic failure (HP:0100626)	2.78353308
16	Neoplasm of the adrenal cortex (HP:0100641)	2.75909689
17	Genital tract atresia (HP:0001827)	2.74613892
18	True hermaphroditism (HP:0010459)	2.73275862
19	Long clavicles (HP:0000890)	2.68754809
20	Microglossia (HP:0000171)	2.68157721
21	Hypothermia (HP:0002045)	2.66301157
22	Spontaneous abortion (HP:0005268)	2.63212928
23	Hepatoblastoma (HP:0002884)	2.62949160
24	Abnormality of the pubic bones (HP:0003172)	2.59169698
25	Medial flaring of the eyebrow (HP:0010747)	2.53639040
26	Steatorrhea (HP:0002570)	2.50633261
27	Tubulointerstitial fibrosis (HP:0005576)	2.49775001
28	Retrobulbar optic neuritis (HP:0100654)	2.47460149
29	Optic neuritis (HP:0100653)	2.47460149
30	Acute encephalopathy (HP:0006846)	2.44040710
31	Bifid tongue (HP:0010297)	2.43388587
32	Broad-based gait (HP:0002136)	2.42357388
33	Increased CSF lactate (HP:0002490)	2.42287036
34	Tetraparesis (HP:0002273)	2.37688015
35	Molar tooth sign on MRI (HP:0002419)	2.33254548
36	Abnormality of midbrain morphology (HP:0002418)	2.33254548
37	Abnormality of the pancreatic islet cells (HP:0006476)	2.32249032
38	Abnormality of endocrine pancreas physiology (HP:0012093)	2.32249032
39	Abnormal mitochondria in muscle tissue (HP:0008316)	2.31419089
40	Ketosis (HP:0001946)	2.31086359
41	Large eyes (HP:0001090)	2.29140675
42	Prominent supraorbital ridges (HP:0000336)	2.28573305
43	Type I transferrin isoform profile (HP:0003642)	2.28098867
44	Hyperinsulinemic hypoglycemia (HP:0000825)	2.26611089
45	Vaginal atresia (HP:0000148)	2.22185255
46	Limb dystonia (HP:0002451)	2.20066143
47	Hypoglycemic coma (HP:0001325)	2.19545683
48	Abnormality of urine glucose concentration (HP:0011016)	2.18499821
49	Glycosuria (HP:0003076)	2.18499821
50	Cystic liver disease (HP:0006706)	2.18051040
51	Volvulus (HP:0002580)	2.12229488
52	Polyphagia (HP:0002591)	2.12183354
53	3-Methylglutaconic aciduria (HP:0003535)	2.11491347
54	Gait imbalance (HP:0002141)	2.10918649
55	Congenital primary aphakia (HP:0007707)	2.10619412
56	Amyotrophic lateral sclerosis (HP:0007354)	2.10539204
57	Congenital hepatic fibrosis (HP:0002612)	2.06498214
58	Peripheral hypomyelination (HP:0007182)	2.05898438
59	Increased serum lactate (HP:0002151)	2.04968919
60	Hypomagnesemia (HP:0002917)	2.04135444
61	Colon cancer (HP:0003003)	2.04074251
62	Cerebral edema (HP:0002181)	2.03523237
63	Spastic tetraplegia (HP:0002510)	2.02481080
64	Pachygyria (HP:0001302)	1.99691492
65	Nephrogenic diabetes insipidus (HP:0009806)	1.99307150
66	Optic disc pallor (HP:0000543)	1.98919106
67	Hepatic necrosis (HP:0002605)	1.98599942
68	Abnormality of the labia minora (HP:0012880)	1.97466746
69	Occipital encephalocele (HP:0002085)	1.97271092
70	Mitochondrial inheritance (HP:0001427)	1.95784677
71	Gaze-evoked nystagmus (HP:0000640)	1.95443147
72	Abnormality of methionine metabolism (HP:0010901)	1.93875525
73	Fat malabsorption (HP:0002630)	1.91314151
74	Progressive inability to walk (HP:0002505)	1.91115011
75	Hepatocellular necrosis (HP:0001404)	1.90824679
76	Hypobetalipoproteinemia (HP:0003563)	1.89918691
77	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.89763723
78	Stomach cancer (HP:0012126)	1.87520692
79	Pancreatitis (HP:0001733)	1.86261478
80	Abnormality of dental color (HP:0011073)	1.84329782
81	Tubulointerstitial abnormality (HP:0001969)	1.83288676
82	Constricted visual fields (HP:0001133)	1.80956681
83	Anteriorly placed anus (HP:0001545)	1.80290314
84	Nephronophthisis (HP:0000090)	1.79692669
85	Abnormality of glycine metabolism (HP:0010895)	1.78967297
86	Abnormality of serine family amino acid metabolism (HP:0010894)	1.78967297
87	Abnormality of the renal medulla (HP:0100957)	1.78821638
88	Hypsarrhythmia (HP:0002521)	1.78460452
89	Median cleft lip (HP:0000161)	1.78131740
90	Pancreatic islet-cell hyperplasia (HP:0004510)	1.77552289
91	Popliteal pterygium (HP:0009756)	1.75590401
92	Amelogenesis imperfecta (HP:0000705)	1.75076399
93	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.74839162
94	Hyperglycemia (HP:0003074)	1.74572804
95	Furrowed tongue (HP:0000221)	1.73932665
96	Abnormality of the renal cortex (HP:0011035)	1.73214815
97	Abnormality of the hip-girdle musculature (HP:0001445)	1.71303376
98	Abnormality of the musculature of the pelvis (HP:0001469)	1.71303376
99	Neonatal respiratory distress (HP:0002643)	1.70749176
100	Hyperglycinuria (HP:0003108)	1.70379091

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.54595038
2	FRK	4.50115422
3	MAP2K6	3.55438928
4	CASK	3.34958488
5	ACVR1B	3.08550593
6	WNK3	2.98100641
7	BMPR1B	2.86760897
8	MAP3K4	2.82914628
9	TRIM28	2.51591981
10	FER	2.09680823
11	BCKDK	1.75125223
12	MAPK13	1.72589382
13	MAP3K12	1.69574900
14	MKNK2	1.64964806
15	MINK1	1.61603578
16	EPHA3	1.61488384
17	MAP2K4	1.58516264
18	NUAK1	1.52855829
19	MAP2K7	1.49552396
20	BCR	1.47368696
21	ZAK	1.46649932
22	CSNK1G2	1.44591463
23	DYRK2	1.38326094
24	MST4	1.33446161
25	CSNK1G1	1.32862819
26	STK16	1.32456638
27	PLK2	1.31705830
28	CSNK1G3	1.26371150
29	STK39	1.25849379
30	FGFR2	1.18736756
31	STK38L	1.16839588
32	INSRR	1.16158868
33	CSNK1A1L	1.14659630
34	MARK1	1.13073210
35	ERBB3	1.12761542
36	VRK2	1.12259808
37	PDK2	1.07252904
38	PRKCE	1.01273345
39	PNCK	0.99722621
40	PAK3	0.94449579
41	TGFBR1	0.88825249
42	CAMKK2	0.87625272
43	GRK5	0.87620470
44	PLK3	0.84898896
45	MKNK1	0.84683492
46	NEK1	0.84290618
47	PBK	0.83400594
48	PRKCG	0.82734303
49	TIE1	0.81771632
50	WNK4	0.79993183
51	ADRBK1	0.79527230
52	ADRBK2	0.74624988
53	CAMK2A	0.74527068
54	TAOK3	0.73217896
55	MYLK	0.72955355
56	TNIK	0.72107290
57	GRK1	0.69447328
58	BRSK2	0.69355432
59	TSSK6	0.62862300
60	NTRK3	0.59906896
61	PRKACB	0.59563362
62	MAP3K2	0.54596739
63	ALK	0.54083669
64	NLK	0.52901277
65	PINK1	0.52834910
66	DAPK2	0.51061815
67	PLK4	0.50286234
68	NME1	0.49941324
69	TGFBR2	0.49742981
70	MAPKAPK5	0.48399019
71	CSNK1A1	0.46255074
72	RPS6KB2	0.45403539
73	YES1	0.44275940
74	OXSR1	0.42274822
75	CSNK1D	0.41894898
76	PRKACA	0.41763927
77	BUB1	0.41541090
78	MATK	0.40294007
79	PRKCQ	0.40166441
80	PRKCZ	0.39715564
81	LIMK1	0.39280200
82	EIF2AK3	0.37247991
83	RPS6KB1	0.34729579
84	MAP3K5	0.34399638
85	PKN1	0.34279711
86	ABL1	0.32369423
87	UHMK1	0.31815899
88	CDK5	0.31147534
89	DAPK1	0.30638810
90	ROCK1	0.29873146
91	CAMK2D	0.29237238
92	PRKCA	0.29123464
93	FGFR1	0.28889444
94	PRKG1	0.28169538
95	PRKAA1	0.28080210
96	IGF1R	0.28054588
97	GSK3A	0.27169661
98	ROCK2	0.27099824
99	EGFR	0.26438743
100	MAP3K6	0.25747964

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.72377083
2	Butanoate metabolism_Homo sapiens_hsa00650	3.34676057
3	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.94793621
4	Propanoate metabolism_Homo sapiens_hsa00640	2.83286731
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.44219906
6	Nicotine addiction_Homo sapiens_hsa05033	2.34220992
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.29507070
8	Protein export_Homo sapiens_hsa03060	2.29304524
9	Sulfur metabolism_Homo sapiens_hsa00920	2.17396232
10	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.13986537
11	Fatty acid elongation_Homo sapiens_hsa00062	2.10655923
12	Proteasome_Homo sapiens_hsa03050	2.07764857
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.03898947
14	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.03314571
15	Steroid biosynthesis_Homo sapiens_hsa00100	2.01858222
16	Parkinsons disease_Homo sapiens_hsa05012	1.90621505
17	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.84248049
18	Fatty acid metabolism_Homo sapiens_hsa01212	1.79770346
19	Non-homologous end-joining_Homo sapiens_hsa03450	1.79142639
20	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.77502448
21	RNA polymerase_Homo sapiens_hsa03020	1.76378320
22	Homologous recombination_Homo sapiens_hsa03440	1.66359324
23	Basal transcription factors_Homo sapiens_hsa03022	1.61544379
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.59103227
25	GABAergic synapse_Homo sapiens_hsa04727	1.58885707
26	Base excision repair_Homo sapiens_hsa03410	1.54386558
27	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.46704875
28	Caffeine metabolism_Homo sapiens_hsa00232	1.45460039
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.41595806
30	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.37459553
31	Huntingtons disease_Homo sapiens_hsa05016	1.31582227
32	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.24178783
33	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.23022978
34	Phototransduction_Homo sapiens_hsa04744	1.22442289
35	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.19001690
36	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.17185483
37	Folate biosynthesis_Homo sapiens_hsa00790	1.14305757
38	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.13363631
39	beta-Alanine metabolism_Homo sapiens_hsa00410	1.12565362
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.07503298
41	Circadian rhythm_Homo sapiens_hsa04710	1.07352478
42	Peroxisome_Homo sapiens_hsa04146	1.05160087
43	Selenocompound metabolism_Homo sapiens_hsa00450	1.05156086
44	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.04881209
45	Morphine addiction_Homo sapiens_hsa05032	1.02555863
46	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.99442308
47	Glutathione metabolism_Homo sapiens_hsa00480	0.98055465
48	Alzheimers disease_Homo sapiens_hsa05010	0.96562415
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.91514139
50	Pyruvate metabolism_Homo sapiens_hsa00620	0.87744122
51	Circadian entrainment_Homo sapiens_hsa04713	0.87636892
52	Fatty acid degradation_Homo sapiens_hsa00071	0.83349156
53	One carbon pool by folate_Homo sapiens_hsa00670	0.82797674
54	Purine metabolism_Homo sapiens_hsa00230	0.82612618
55	Metabolic pathways_Homo sapiens_hsa01100	0.82575120
56	Glycerolipid metabolism_Homo sapiens_hsa00561	0.82120020
57	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.80395527
58	Regulation of autophagy_Homo sapiens_hsa04140	0.79262244
59	Collecting duct acid secretion_Homo sapiens_hsa04966	0.78430661
60	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.77036428
61	Taste transduction_Homo sapiens_hsa04742	0.73743549
62	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.73297745
63	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.71317969
64	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.70837439
65	Insulin secretion_Homo sapiens_hsa04911	0.70689862
66	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.69669794
67	RNA degradation_Homo sapiens_hsa03018	0.67725485
68	Cardiac muscle contraction_Homo sapiens_hsa04260	0.65608584
69	Olfactory transduction_Homo sapiens_hsa04740	0.64509173
70	Retinol metabolism_Homo sapiens_hsa00830	0.64098319
71	Fat digestion and absorption_Homo sapiens_hsa04975	0.63626526
72	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.63580305
73	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.63562310
74	Dopaminergic synapse_Homo sapiens_hsa04728	0.63016429
75	Linoleic acid metabolism_Homo sapiens_hsa00591	0.58980867
76	Glutamatergic synapse_Homo sapiens_hsa04724	0.58336504
77	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.56640232
78	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.55152915
79	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.54039329
80	Pyrimidine metabolism_Homo sapiens_hsa00240	0.53281594
81	RNA transport_Homo sapiens_hsa03013	0.53262962
82	Salivary secretion_Homo sapiens_hsa04970	0.52647248
83	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.52412865
84	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.52217683
85	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.52054906
86	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49456122
87	Mismatch repair_Homo sapiens_hsa03430	0.48940687
88	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.48410394
89	Ether lipid metabolism_Homo sapiens_hsa00565	0.43010798
90	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.41055217
91	Carbon metabolism_Homo sapiens_hsa01200	0.40353158
92	Serotonergic synapse_Homo sapiens_hsa04726	0.39497429
93	Sphingolipid metabolism_Homo sapiens_hsa00600	0.36470060
94	PPAR signaling pathway_Homo sapiens_hsa03320	0.35395459
95	Sulfur relay system_Homo sapiens_hsa04122	0.34891192
96	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.34152923
97	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.31670552
98	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.30756054
99	Histidine metabolism_Homo sapiens_hsa00340	0.30532241
100	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.26740852

NT5CP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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