NT5DC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: While the exact function of the protein encoded by this gene is not known, it belongs to the 5'(3')-deoxyribonucleotidase family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.44981822
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.44981822
3establishment of integrated proviral latency (GO:0075713)3.95314331
4purine nucleobase biosynthetic process (GO:0009113)3.93799194
5antigen processing and presentation of endogenous antigen (GO:0019883)3.87706270
6positive regulation of gamma-delta T cell activation (GO:0046645)3.84750728
7ribosomal small subunit assembly (GO:0000028)3.78445767
8branched-chain amino acid catabolic process (GO:0009083)3.65739407
9ribosomal large subunit biogenesis (GO:0042273)3.59634496
10ribosome assembly (GO:0042255)3.59369044
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.59321929
12regulation of mitochondrial translation (GO:0070129)3.52296102
13formation of translation preinitiation complex (GO:0001731)3.44652209
14oxidative phosphorylation (GO:0006119)3.43768229
15proteasome assembly (GO:0043248)3.43524158
16CENP-A containing nucleosome assembly (GO:0034080)3.42626885
17mitochondrial DNA replication (GO:0006264)3.41782083
18interferon-gamma production (GO:0032609)3.37792523
19chromatin remodeling at centromere (GO:0031055)3.36810303
20lactate metabolic process (GO:0006089)3.34969930
21nucleobase biosynthetic process (GO:0046112)3.34325642
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.32781670
23valine metabolic process (GO:0006573)3.26232560
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.22382812
25AMP metabolic process (GO:0046033)3.20904788
26NADH metabolic process (GO:0006734)3.20148426
27L-serine metabolic process (GO:0006563)3.16969326
28definitive hemopoiesis (GO:0060216)3.16798929
29regulation of gamma-delta T cell differentiation (GO:0045586)3.16661343
30regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.14141121
31DNA replication checkpoint (GO:0000076)3.13065723
32tricarboxylic acid cycle (GO:0006099)3.12299940
33respiratory chain complex IV assembly (GO:0008535)3.09727977
34mitotic recombination (GO:0006312)3.08214639
35water-soluble vitamin biosynthetic process (GO:0042364)3.06574803
36positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.03497990
37positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.02827288
38regulation of helicase activity (GO:0051095)2.91932243
39negative regulation of ligase activity (GO:0051352)2.91210759
40negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.91210759
41regulation of gamma-delta T cell activation (GO:0046643)2.91120136
42branched-chain amino acid metabolic process (GO:0009081)2.90432288
43aldehyde catabolic process (GO:0046185)2.86758484
44erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.84106865
45L-phenylalanine catabolic process (GO:0006559)2.84106865
46histone exchange (GO:0043486)2.83162881
47establishment of viral latency (GO:0019043)2.82163871
48erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.81340176
49L-phenylalanine metabolic process (GO:0006558)2.81340176
50anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.80600791
51aromatic amino acid family catabolic process (GO:0009074)2.80344125
52rRNA modification (GO:0000154)2.80323338
53regulation of cellular amino acid metabolic process (GO:0006521)2.79307888
54folic acid-containing compound biosynthetic process (GO:0009396)2.77892657
55somatic hypermutation of immunoglobulin genes (GO:0016446)2.77748024
56somatic diversification of immune receptors via somatic mutation (GO:0002566)2.77748024
57indolalkylamine catabolic process (GO:0046218)2.74049607
58tryptophan catabolic process (GO:0006569)2.74049607
59indole-containing compound catabolic process (GO:0042436)2.74049607
60peptidyl-histidine modification (GO:0018202)2.73557216
61tryptophan metabolic process (GO:0006568)2.73023524
62rRNA methylation (GO:0031167)2.71629333
63positive regulation of B cell differentiation (GO:0045579)2.71019437
64telomere maintenance via telomere lengthening (GO:0010833)2.69652767
65translation (GO:0006412)2.67572514
66fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.65529980
67translational initiation (GO:0006413)2.65498506
68double-strand break repair via nonhomologous end joining (GO:0006303)2.61959390
69non-recombinational repair (GO:0000726)2.61959390
70positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.59948645
71L-ascorbic acid metabolic process (GO:0019852)2.59837683
72ethanol oxidation (GO:0006069)2.59206881
73cytochrome complex assembly (GO:0017004)2.59070640
74regulation of B cell differentiation (GO:0045577)2.58819605
75fatty acid homeostasis (GO:0055089)2.58127955
76mitotic G2/M transition checkpoint (GO:0044818)2.57813203
77DNA double-strand break processing (GO:0000729)2.56962805
78mitochondrial DNA metabolic process (GO:0032042)2.56694395
79DNA replication-independent nucleosome organization (GO:0034724)2.56606844
80DNA replication-independent nucleosome assembly (GO:0006336)2.56606844
81glucuronate metabolic process (GO:0019585)2.56592926
82uronic acid metabolic process (GO:0006063)2.56592926
83positive regulation of ligase activity (GO:0051351)2.55187421
84protein carboxylation (GO:0018214)2.53015349
85peptidyl-glutamic acid carboxylation (GO:0017187)2.53015349
86pteridine-containing compound biosynthetic process (GO:0042559)2.52930841
87glyoxylate metabolic process (GO:0046487)2.52692031
88telomere maintenance via semi-conservative replication (GO:0032201)2.52164343
89Arp2/3 complex-mediated actin nucleation (GO:0034314)2.49994464
90DNA ligation (GO:0006266)2.48780927
91ribosomal small subunit biogenesis (GO:0042274)2.48693224
92nucleotide-sugar biosynthetic process (GO:0009226)2.47920248
93DNA catabolic process, exonucleolytic (GO:0000738)2.46895699
94DNA unwinding involved in DNA replication (GO:0006268)2.46659993
95ATP synthesis coupled proton transport (GO:0015986)2.46041912
96energy coupled proton transport, down electrochemical gradient (GO:0015985)2.46041912
97oxaloacetate metabolic process (GO:0006107)2.45127491
98serine family amino acid biosynthetic process (GO:0009070)2.45113800
99signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.45059954
100signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.45059954
101signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.45059954
102maturation of SSU-rRNA (GO:0030490)2.44991064
103necroptotic process (GO:0070266)2.44111140
104ethanol metabolic process (GO:0006067)2.43686260
105ribonucleoprotein complex biogenesis (GO:0022613)2.42902155
106sulfur amino acid catabolic process (GO:0000098)2.42624530
107DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.42471626
108kynurenine metabolic process (GO:0070189)2.42251629
109urate metabolic process (GO:0046415)2.42021602
110glycine metabolic process (GO:0006544)2.41639110
111negative T cell selection (GO:0043383)2.40030356
112antigen processing and presentation via MHC class Ib (GO:0002475)2.39819251
113bile acid biosynthetic process (GO:0006699)2.38909744
114regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.38888321
115negative thymic T cell selection (GO:0045060)2.38346170
116urea metabolic process (GO:0019627)2.35200396
117urea cycle (GO:0000050)2.35200396
118DNA strand elongation (GO:0022616)2.35111932
119signal peptide processing (GO:0006465)2.34876595
120IMP biosynthetic process (GO:0006188)2.34851595
121DNA strand elongation involved in DNA replication (GO:0006271)2.32776914
122lysine catabolic process (GO:0006554)2.32692163
123lysine metabolic process (GO:0006553)2.32692163
124tetrahydrofolate metabolic process (GO:0046653)2.31572984
125regulation of B cell receptor signaling pathway (GO:0050855)2.30929465
126SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.30116667
127cysteine metabolic process (GO:0006534)2.29831898
128DNA replication initiation (GO:0006270)2.29828901
129IMP metabolic process (GO:0046040)2.29711809
130folic acid metabolic process (GO:0046655)2.28969828
131response to interferon-beta (GO:0035456)2.28955454
132positive regulation of T cell mediated cytotoxicity (GO:0001916)2.25318715
133regulation of T cell receptor signaling pathway (GO:0050856)2.24913164
134regulation of interleukin-12 biosynthetic process (GO:0045075)2.24153555
135telomere maintenance via recombination (GO:0000722)2.23019963
136viral transcription (GO:0019083)2.22935379
137hepatocyte apoptotic process (GO:0097284)2.21199959
138cotranslational protein targeting to membrane (GO:0006613)2.20526821
139protein targeting to ER (GO:0045047)2.20422192
140mature B cell differentiation involved in immune response (GO:0002313)2.19808998
141amino-acid betaine metabolic process (GO:0006577)2.19221837
142alpha-linolenic acid metabolic process (GO:0036109)2.19014131
143translational termination (GO:0006415)2.18661278
144regulation of triglyceride catabolic process (GO:0010896)2.16750427
145regulation of T cell mediated cytotoxicity (GO:0001914)2.15407027
146imidazole-containing compound metabolic process (GO:0052803)2.14232639
147B cell mediated immunity (GO:0019724)2.14031265
148pteridine-containing compound metabolic process (GO:0042558)2.13380485
149serine family amino acid metabolic process (GO:0009069)2.12836414
150drug transmembrane transport (GO:0006855)2.12394053
151positive regulation of interferon-alpha production (GO:0032727)2.11458779
152drug transport (GO:0015893)2.10393640
153protein localization to endoplasmic reticulum (GO:0070972)2.10165465
154cellular glucuronidation (GO:0052695)2.09304692
155folic acid-containing compound metabolic process (GO:0006760)2.09157018
156regulation of response to interferon-gamma (GO:0060330)2.09052223
157leukocyte aggregation (GO:0070486)2.09022633
158triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.08369355
159one-carbon metabolic process (GO:0006730)2.08334349
160positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.07489859
161translesion synthesis (GO:0019985)2.06751653
162establishment of protein localization to endoplasmic reticulum (GO:0072599)2.06321240
163nitrogen cycle metabolic process (GO:0071941)2.06111212
164regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.05612515
165NIK/NF-kappaB signaling (GO:0038061)2.05501790
166mast cell activation (GO:0045576)2.05416121
167complement activation, alternative pathway (GO:0006957)2.05252097
168blood coagulation, intrinsic pathway (GO:0007597)2.04384569
169regulation of interferon-alpha production (GO:0032647)2.04083982
170immunoglobulin mediated immune response (GO:0016064)2.04001951
171negative regulation of phagocytosis (GO:0050765)2.03340334
172chaperone mediated protein folding requiring cofactor (GO:0051085)2.02556908

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.46156498
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.48374971
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.23775535
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.08959044
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.72618914
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.71428656
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.57875091
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.49523105
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.44995547
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.42536958
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.42154979
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.41727500
13GATA1_22025678_ChIP-Seq_K562_Human2.39239634
14* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.36018201
15SCL_19346495_ChIP-Seq_HPC-7_Human2.32313987
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.31235330
17PPARA_22158963_ChIP-Seq_LIVER_Mouse2.30209961
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.22477876
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.14783672
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.08358459
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.02767957
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.02482107
23* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.98220655
24MYC_22102868_ChIP-Seq_BL_Human1.96266341
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.96104957
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.96033854
27PADI4_21655091_ChIP-ChIP_MCF-7_Human1.95624480
28TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.89650796
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.88520661
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.86722398
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80513726
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.79428037
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.76765435
34* SPI1_23547873_ChIP-Seq_NB4_Human1.72251950
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71980511
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.71970026
37MYB_26560356_Chip-Seq_TH2_Human1.71495889
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.68496325
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.67652702
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63767899
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.62689227
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62642498
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.62370179
44VDR_23849224_ChIP-Seq_CD4+_Human1.61887220
45* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61731068
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.61365176
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.60752359
48LXR_22158963_ChIP-Seq_LIVER_Mouse1.60715358
49MYB_26560356_Chip-Seq_TH1_Human1.59616110
50PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.56903969
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56477090
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.56445563
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55858880
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53755760
55STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.53144247
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52676850
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52447737
58RUNX1_22412390_ChIP-Seq_EML_Mouse1.49559448
59* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49488986
60MAF_26560356_Chip-Seq_TH1_Human1.48535388
61* TTF2_22483619_ChIP-Seq_HELA_Human1.46103799
62MYC_18358816_ChIP-ChIP_MESCs_Mouse1.44144288
63FOXP3_21729870_ChIP-Seq_TREG_Human1.43671794
64FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.43567002
65FOXM1_23109430_ChIP-Seq_U2OS_Human1.43419487
66KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.42830453
67IRF8_27001747_Chip-Seq_BMDM_Mouse1.42702581
68BP1_19119308_ChIP-ChIP_Hs578T_Human1.42006636
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.40735013
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40436087
71* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40359265
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.40151342
73NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39008791
74JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37758660
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37574360
76STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35181324
77MYC_19030024_ChIP-ChIP_MESCs_Mouse1.34535581
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34469856
79RUNX_20019798_ChIP-Seq_JUKART_Human1.34373781
80CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34012987
81THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33428241
82MYC_18940864_ChIP-ChIP_HL60_Human1.31291646
83* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31240171
84SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30783712
85SRF_21415370_ChIP-Seq_HL-1_Mouse1.29741052
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29261768
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.28951532
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28359847
89VDR_21846776_ChIP-Seq_THP-1_Human1.27991033
90UTX_26944678_Chip-Seq_JUKART_Human1.27607657
91* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26858110
92* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22608645
93FUS_26573619_Chip-Seq_HEK293_Human1.21480552
94ETS1_20019798_ChIP-Seq_JURKAT_Human1.21065360
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.20914156
96AR_21909140_ChIP-Seq_LNCAP_Human1.20411699
97MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20275644
98CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.18578765
99LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18513937
100* XRN2_22483619_ChIP-Seq_HELA_Human1.18198565
101DCP1A_22483619_ChIP-Seq_HELA_Human1.17538193
102LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16941873
103MYC_19079543_ChIP-ChIP_MESCs_Mouse1.16330731
104NANOG_16153702_ChIP-ChIP_HESCs_Human1.15131126
105* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.14569771
106POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14187335
107EWS_26573619_Chip-Seq_HEK293_Human1.14170803
108PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13108078
109SOX17_20123909_ChIP-Seq_XEN_Mouse1.12606380
110E2F1_21310950_ChIP-Seq_MCF-7_Human1.11917841
111ELK1_19687146_ChIP-ChIP_HELA_Human1.11404574
112RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10436140
113FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.10081116
114NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09899481
115TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09557226
116SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07998706
117HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07519850
118TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06662509
119POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05978543
120CIITA_25753668_ChIP-Seq_RAJI_Human1.05712959
121GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04832416
122VDR_24763502_ChIP-Seq_THP-1_Human1.03488445
123TFEB_21752829_ChIP-Seq_HELA_Human1.02933053
124GABP_19822575_ChIP-Seq_HepG2_Human1.02314693
125KDM5A_27292631_Chip-Seq_BREAST_Human1.00980531
126ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00737988
127TCF7_22412390_ChIP-Seq_EML_Mouse1.00165448
128SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00088345
129GATA3_27048872_Chip-Seq_THYMUS_Human0.99724462
130RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99202650
131MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.98872298
132NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97583611
133CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.96801828
134ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93851959
135E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93365655
136MAF_26560356_Chip-Seq_TH2_Human0.91489313
137E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90276728
138FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88968251
139PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87936443
140FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.87160178
141IRF1_19129219_ChIP-ChIP_H3396_Human0.86478313
142NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86341050
143ELF5_23300383_ChIP-Seq_T47D_Human0.85968825
144HTT_18923047_ChIP-ChIP_STHdh_Human0.85180590
145CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84111708
146BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81822878
147TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80994289
148SALL1_21062744_ChIP-ChIP_HESCs_Human0.80811937
149FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.80197636
150CHD1_26751641_Chip-Seq_LNCaP_Human0.79609515
151SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79529874
152STAT3_1855785_ChIP-Seq_MESCs_Mouse0.78129923
153FOXA1_27270436_Chip-Seq_PROSTATE_Human0.78063389
154FOXA1_25329375_ChIP-Seq_VCAP_Human0.78063389
155IGF1R_20145208_ChIP-Seq_DFB_Human0.77026643

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development3.52243516
2MP0002139_abnormal_hepatobiliary_system3.12063708
3MP0005360_urolithiasis3.05034328
4MP0003806_abnormal_nucleotide_metabolis2.80353440
5MP0001835_abnormal_antigen_presentation2.65925881
6MP0002396_abnormal_hematopoietic_system2.60289266
7MP0005365_abnormal_bile_salt2.54868682
8MP0003763_abnormal_thymus_physiology2.49936458
9MP0005085_abnormal_gallbladder_physiolo2.46673109
10MP0005671_abnormal_response_to2.31898630
11MP0006036_abnormal_mitochondrial_physio2.31262288
12MP0003436_decreased_susceptibility_to2.27611911
13MP0008875_abnormal_xenobiotic_pharmacok2.20395121
14MP0001661_extended_life_span2.11535568
15MP0009785_altered_susceptibility_to2.04975294
16MP0010234_abnormal_vibrissa_follicle2.02507088
17MP0005464_abnormal_platelet_physiology1.97292652
18MP0000685_abnormal_immune_system1.96482032
19MP0003724_increased_susceptibility_to1.91486603
20MP0001800_abnormal_humoral_immune1.89957768
21MP0003718_maternal_effect1.88646222
22MP0008877_abnormal_DNA_methylation1.79108821
23MP0002166_altered_tumor_susceptibility1.76987624
24MP0002398_abnormal_bone_marrow1.71427653
25MP0006054_spinal_hemorrhage1.70467940
26MP0005379_endocrine/exocrine_gland_phen1.69063431
27MP0003195_calcinosis1.68296354
28MP0005025_abnormal_response_to1.67500756
29MP0002723_abnormal_immune_serum1.66374756
30MP0002163_abnormal_gland_morphology1.66103269
31MP0005000_abnormal_immune_tolerance1.65221422
32MP0001873_stomach_inflammation1.64712696
33MP0002452_abnormal_antigen_presenting1.63092502
34MP0002420_abnormal_adaptive_immunity1.62062661
35MP0000689_abnormal_spleen_morphology1.61580881
36MP0001819_abnormal_immune_cell1.59657800
37MP0006035_abnormal_mitochondrial_morpho1.59139951
38MP0001853_heart_inflammation1.58490508
39MP0003693_abnormal_embryo_hatching1.56902567
40MP0005408_hypopigmentation1.56209321
41MP0005397_hematopoietic_system_phenotyp1.54877121
42MP0001545_abnormal_hematopoietic_system1.54877121
43MP0003656_abnormal_erythrocyte_physiolo1.54339850
44MP0005387_immune_system_phenotype1.52301193
45MP0001790_abnormal_immune_system1.52301193
46MP0010329_abnormal_lipoprotein_level1.49601511
47MP0002722_abnormal_immune_system1.49086288
48MP0009333_abnormal_splenocyte_physiolog1.48861318
49MP0002419_abnormal_innate_immunity1.48439422
50MP0002006_tumorigenesis1.47527118
51MP0002405_respiratory_system_inflammati1.46556148
52MP0000465_gastrointestinal_hemorrhage1.45654013
53MP0000716_abnormal_immune_system1.45523108
54MP0004808_abnormal_hematopoietic_stem1.45193502
55MP0008057_abnormal_DNA_replication1.45135051
56MP0001764_abnormal_homeostasis1.44508106
57MP0003186_abnormal_redox_activity1.43952017
58MP0002876_abnormal_thyroid_physiology1.43837757
59MP0006082_CNS_inflammation1.43390322
60MP0002837_dystrophic_cardiac_calcinosis1.42790061
61MP0010155_abnormal_intestine_physiology1.41367501
62MP0003191_abnormal_cellular_cholesterol1.39869910
63MP0003252_abnormal_bile_duct1.39607375
64MP0001984_abnormal_olfaction1.38926783
65MP0001730_embryonic_growth_arrest1.38885822
66MP0005075_abnormal_melanosome_morpholog1.38553760
67MP0000609_abnormal_liver_physiology1.38342965
68MP0003300_gastrointestinal_ulcer1.38031749
69MP0008469_abnormal_protein_level1.37953492
70MP0008932_abnormal_embryonic_tissue1.36824190
71MP0009697_abnormal_copulation1.36795010
72MP0002429_abnormal_blood_cell1.36268659
73MP0009840_abnormal_foam_cell1.35875682
74MP0000490_abnormal_crypts_of1.33499612
75MP0010094_abnormal_chromosome_stability1.32768442
76MP0003123_paternal_imprinting1.32705165
77MP0003890_abnormal_embryonic-extraembry1.32482418
78MP0001845_abnormal_inflammatory_respons1.31800959
79MP0005330_cardiomyopathy1.30583340
80MP0002148_abnormal_hypersensitivity_rea1.30145793
81MP0008007_abnormal_cellular_replicative1.27210486
82MP0010678_abnormal_skin_adnexa1.26120812
83MP0010352_gastrointestinal_tract_polyps1.25231178
84MP0001666_abnormal_nutrient_absorption1.24953756
85MP0004215_abnormal_myocardial_fiber1.24672278
86MP0003868_abnormal_feces_composition1.22556941
87MP0002933_joint_inflammation1.20661462
88MP0005319_abnormal_enzyme/_coenzyme1.20227920
89MP0005332_abnormal_amino_acid1.19926270
90MP0002138_abnormal_hepatobiliary_system1.19747060
91MP0009672_abnormal_birth_weight1.19722974
92MP0002090_abnormal_vision1.19057166
93MP0000372_irregular_coat_pigmentation1.19034369
94MP0005084_abnormal_gallbladder_morpholo1.18525583
95MP0009643_abnormal_urine_homeostasis1.18437122
96MP0000703_abnormal_thymus_morphology1.16038240
97MP0002160_abnormal_reproductive_system1.14337834
98MP0004947_skin_inflammation1.13960925
99MP0000350_abnormal_cell_proliferation1.11679878
100MP0004147_increased_porphyrin_level1.11482938
101MP0000383_abnormal_hair_follicle1.09130377
102MP0006072_abnormal_retinal_apoptosis1.09100320
103MP0001533_abnormal_skeleton_physiology1.08980440
104MP0000598_abnormal_liver_morphology1.08820906
105MP0009763_increased_sensitivity_to1.06847850
106MP0003077_abnormal_cell_cycle1.06742547
107MP0001697_abnormal_embryo_size1.04238178
108MP0002019_abnormal_tumor_incidence1.01351408
109MP0009780_abnormal_chondrocyte_physiolo1.01195464
110MP0003866_abnormal_defecation1.01111923
111MP0004264_abnormal_extraembryonic_tissu0.99231551
112MP0003567_abnormal_fetal_cardiomyocyte0.98789100
113MP0008058_abnormal_DNA_repair0.98383026
114MP0000858_altered_metastatic_potential0.98273998
115MP0005645_abnormal_hypothalamus_physiol0.96407246
116MP0009764_decreased_sensitivity_to0.94866903
117MP0002132_abnormal_respiratory_system0.92871049
118MP0005023_abnormal_wound_healing0.92518474
119MP0001293_anophthalmia0.91887286
120MP0005380_embryogenesis_phenotype0.90448414
121MP0001672_abnormal_embryogenesis/_devel0.90448414
122MP0004957_abnormal_blastocyst_morpholog0.90124917
123MP0003111_abnormal_nucleus_morphology0.86997876
124MP0005584_abnormal_enzyme/coenzyme_acti0.86358772
125MP0002136_abnormal_kidney_physiology0.85861467
126MP0009765_abnormal_xenobiotic_induced0.85360805
127MP0002277_abnormal_respiratory_mucosa0.85019098
128MP0000343_altered_response_to0.84168366
129MP0002088_abnormal_embryonic_growth/wei0.83131888
130MP0005395_other_phenotype0.82921324
131MP0003984_embryonic_growth_retardation0.82817668
132MP0002009_preneoplasia0.82227853
133MP0000358_abnormal_cell_content/0.81875530
134MP0002118_abnormal_lipid_homeostasis0.81715623
135MP0003943_abnormal_hepatobiliary_system0.78839016
136MP0003315_abnormal_perineum_morphology0.78833254
137MP0002254_reproductive_system_inflammat0.77436084
138MP0002796_impaired_skin_barrier0.76644090
139MP0005058_abnormal_lysosome_morphology0.76407250
140MP0000462_abnormal_digestive_system0.75668679
141MP0004019_abnormal_vitamin_homeostasis0.75418224
142MP0001929_abnormal_gametogenesis0.75309359
143MP0002080_prenatal_lethality0.74774777
144MP0001881_abnormal_mammary_gland0.74769670
145MP0003011_delayed_dark_adaptation0.74672837
146MP0000313_abnormal_cell_death0.74645516
147MP0000371_diluted_coat_color0.74267118
148MP0002078_abnormal_glucose_homeostasis0.73627584
149MP0001145_abnormal_male_reproductive0.72966791
150MP0005636_abnormal_mineral_homeostasis0.72536729
151MP0002877_abnormal_melanocyte_morpholog0.72265305
152MP0003786_premature_aging0.72208767
153MP0005310_abnormal_salivary_gland0.70632525
154MP0002084_abnormal_developmental_patter0.70163029
155MP0009703_decreased_birth_body0.68001580
156MP0001944_abnormal_pancreas_morphology0.67234495
157MP0005220_abnormal_exocrine_pancreas0.66250987
158MP0002269_muscular_atrophy0.64499419
159MP0000013_abnormal_adipose_tissue0.63962006
160MP0002693_abnormal_pancreas_physiology0.63375939
161MP0008872_abnormal_physiological_respon0.63098452
162MP0000477_abnormal_intestine_morphology0.61330541

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)4.77786807
2Hyperinsulinemic hypoglycemia (HP:0000825)4.29920241
3Abnormality of aromatic amino acid family metabolism (HP:0004338)3.43422590
4Thrombocytosis (HP:0001894)3.37839402
5Lipid accumulation in hepatocytes (HP:0006561)3.35536728
6Increased hepatocellular lipid droplets (HP:0006565)3.25215492
7Hyperglycinuria (HP:0003108)3.20156535
8Symptomatic seizures (HP:0011145)3.19084602
9Myositis (HP:0100614)3.17668520
10Abnormality of serine family amino acid metabolism (HP:0010894)3.16644817
11Abnormality of glycine metabolism (HP:0010895)3.16644817
12Intrahepatic cholestasis (HP:0001406)3.13237381
13Hyperglycinemia (HP:0002154)3.12637350
14Abnormality of monocarboxylic acid metabolism (HP:0010996)3.05770647
15IgM deficiency (HP:0002850)3.01472900
16Gout (HP:0001997)2.96075948
17Joint hemorrhage (HP:0005261)2.93675946
18Epistaxis (HP:0000421)2.89515271
19Prolonged partial thromboplastin time (HP:0003645)2.85233779
20Petechiae (HP:0000967)2.83691221
21Hepatic necrosis (HP:0002605)2.83579387
22Abnormality of serum amino acid levels (HP:0003112)2.83023078
23Methylmalonic acidemia (HP:0002912)2.82087085
24Increased serum pyruvate (HP:0003542)2.81722886
25Pancreatic islet-cell hyperplasia (HP:0004510)2.80054947
26Abnormality of the common coagulation pathway (HP:0010990)2.79361034
27Ketoacidosis (HP:0001993)2.78067089
28Glycosuria (HP:0003076)2.75745551
29Abnormality of urine glucose concentration (HP:0011016)2.75745551
30Aplastic anemia (HP:0001915)2.75314803
31Decreased activity of mitochondrial respiratory chain (HP:0008972)2.70833467
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.70833467
33Prolonged bleeding time (HP:0003010)2.70539704
34Microvesicular hepatic steatosis (HP:0001414)2.69121187
35Impaired platelet aggregation (HP:0003540)2.68041777
36Abnormal platelet function (HP:0011869)2.68041777
37Gingival bleeding (HP:0000225)2.65302239
38Chronic bronchitis (HP:0004469)2.64986425
39Abnormality of the intrinsic pathway (HP:0010989)2.64482152
40Abnormality of glycolysis (HP:0004366)2.62654625
41Elevated erythrocyte sedimentation rate (HP:0003565)2.62523112
42Megaloblastic anemia (HP:0001889)2.59165757
43Orchitis (HP:0100796)2.58639682
44Abnormality of T cell physiology (HP:0011840)2.58507605
45Increased intramyocellular lipid droplets (HP:0012240)2.57089643
46Recurrent viral infections (HP:0004429)2.55419433
47Type I transferrin isoform profile (HP:0003642)2.55026211
48Myoglobinuria (HP:0002913)2.54144204
49Cerebral edema (HP:0002181)2.52977114
50Abnormal platelet volume (HP:0011876)2.51699456
51Abnormality of T cells (HP:0002843)2.50478520
52Abnormality of the pancreatic islet cells (HP:0006476)2.47776657
53Abnormality of endocrine pancreas physiology (HP:0012093)2.47776657
54Abnormality of vitamin B metabolism (HP:0004340)2.47746630
55T lymphocytopenia (HP:0005403)2.47181472
56Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.46583656
57Abnormality of pyrimidine metabolism (HP:0004353)2.46268337
58Hypobetalipoproteinemia (HP:0003563)2.44995415
59Chromsome breakage (HP:0040012)2.44918699
60Retrobulbar optic neuritis (HP:0100654)2.44838136
61Optic neuritis (HP:0100653)2.44838136
62Macrocytic anemia (HP:0001972)2.44548800
63Abnormality of T cell number (HP:0011839)2.43498033
64Abnormality of vitamin metabolism (HP:0100508)2.43124054
65Acute encephalopathy (HP:0006846)2.42493984
66Deep venous thrombosis (HP:0002625)2.40094490
67Increased muscle lipid content (HP:0009058)2.39271297
68Palpitations (HP:0001962)2.38140650
69Mitochondrial inheritance (HP:0001427)2.38037359
70Abnormal foot bone ossification (HP:0010675)2.37045556
71Chronic otitis media (HP:0000389)2.36257773
72Increased CSF lactate (HP:0002490)2.35426706
73Hepatocellular necrosis (HP:0001404)2.34108682
74Abnormality of the vitamin B12 metabolism (HP:0004341)2.33638171
75Recurrent bronchitis (HP:0002837)2.33048685
76Acute necrotizing encephalopathy (HP:0006965)2.32845354
77Encephalitis (HP:0002383)2.32310558
78Xanthomatosis (HP:0000991)2.32000934
79Arterial thrombosis (HP:0004420)2.31468083
80Increased mean platelet volume (HP:0011877)2.31011486
81Rhinitis (HP:0012384)2.29785506
82Hypoplasia of the thymus (HP:0000778)2.29485172
83Dicarboxylic aciduria (HP:0003215)2.27914085
84Abnormality of dicarboxylic acid metabolism (HP:0010995)2.27914085
85Keratoconjunctivitis sicca (HP:0001097)2.25912527
86Chromosomal breakage induced by crosslinking agents (HP:0003221)2.25564603
87Rhabdomyolysis (HP:0003201)2.24107077
88Autoimmune thrombocytopenia (HP:0001973)2.23933844
89Reduced antithrombin III activity (HP:0001976)2.23684611
90Recurrent abscess formation (HP:0002722)2.23532761
91Abnormality of fatty-acid metabolism (HP:0004359)2.23321357
92Hyperbilirubinemia (HP:0002904)2.22983252
93Bronchiectasis (HP:0002110)2.22896739
94Metaphyseal cupping (HP:0003021)2.22707551
95Thrombophlebitis (HP:0004418)2.22173506
96Hypoglycemic coma (HP:0001325)2.20403424
97Abnormal respiratory motile cilium physiology (HP:0012261)2.19094741
98Menorrhagia (HP:0000132)2.18872783
99Eczematoid dermatitis (HP:0000976)2.18342439
100Colon cancer (HP:0003003)2.16915913
101Recurrent fungal infections (HP:0002841)2.15624498
102Hyperammonemia (HP:0001987)2.15498257
103Recurrent bacterial skin infections (HP:0005406)2.14340454
104Abnormality of methionine metabolism (HP:0010901)2.14292967
105Proximal tubulopathy (HP:0000114)2.13836486
106Lactic acidosis (HP:0003128)2.13288384
107Anorexia (HP:0002039)2.12919940
108Abnormal mitochondria in muscle tissue (HP:0008316)2.11953119
109Hyperglycemia (HP:0003074)2.11825017
110Fat malabsorption (HP:0002630)2.10380236
111Generalized aminoaciduria (HP:0002909)2.10231811
112Metabolic acidosis (HP:0001942)2.09315545
113Keratoconjunctivitis (HP:0001096)2.09306853
114Recurrent gram-negative bacterial infections (HP:0005420)2.09179623
115Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.07538807
116Abnormal protein N-linked glycosylation (HP:0012347)2.07538807
117Abnormal protein glycosylation (HP:0012346)2.07538807
118Abnormal glycosylation (HP:0012345)2.07538807
119Spontaneous hematomas (HP:0007420)2.07468236
120Renal cortical cysts (HP:0000803)2.06830947
121Progressive macrocephaly (HP:0004481)2.06540115
122Vacuolated lymphocytes (HP:0001922)2.06526861
123Exercise intolerance (HP:0003546)2.06325113
124Joint swelling (HP:0001386)2.05060524
125Abnormality of aspartate family amino acid metabolism (HP:0010899)2.04963131
126Abnormal tarsal ossification (HP:0008369)2.04331476
127Lethargy (HP:0001254)2.03861185
128Abnormality of sulfur amino acid metabolism (HP:0004339)2.03683127
129Right ventricular cardiomyopathy (HP:0011663)2.03487307
130Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.03482855
131Abnormal ciliary motility (HP:0012262)2.03156825
132Methylmalonic aciduria (HP:0012120)2.03009420
133Abnormality of the prostate (HP:0008775)2.02257584
134Increased serum lactate (HP:0002151)2.01939975
135Nasal polyposis (HP:0100582)2.00682759
136Irregular epiphyses (HP:0010582)2.00305093
137Exercise-induced muscle cramps (HP:0003710)1.97049820
138Autoimmune hemolytic anemia (HP:0001890)1.96356843
139Hyperlipoproteinemia (HP:0010980)1.94621688
140Abnormality of glutamine family amino acid metabolism (HP:0010902)1.94357643
141Hyperphosphaturia (HP:0003109)1.94212079
142Beaking of vertebral bodies (HP:0004568)1.93692670
143Purpura (HP:0000979)1.93250862
144Biliary tract neoplasm (HP:0100574)1.92898347
145Granulocytopenia (HP:0001913)1.92733339
146Rhabdomyosarcoma (HP:0002859)1.92720776
147Exertional dyspnea (HP:0002875)1.91488820
148Reticulocytopenia (HP:0001896)1.91142913
149Absent/shortened dynein arms (HP:0200106)1.90823835
150Dynein arm defect of respiratory motile cilia (HP:0012255)1.90823835
151Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.89706148
152Abnormality of the nasal mucosa (HP:0000433)1.88831963
153Abnormality of nucleobase metabolism (HP:0010932)1.88270854
154Complement deficiency (HP:0004431)1.88192997
155Meningitis (HP:0001287)1.87754109
15611 pairs of ribs (HP:0000878)1.87439990
157Hepatocellular carcinoma (HP:0001402)1.86451882
158Panhypogammaglobulinemia (HP:0003139)1.85990980
159Steatorrhea (HP:0002570)1.85715434
160Pulmonary embolism (HP:0002204)1.85237072
161Renal Fanconi syndrome (HP:0001994)1.84242902
162Vasculitis (HP:0002633)1.83930948
163Ketosis (HP:0001946)1.83898195
164Oral leukoplakia (HP:0002745)1.83878588
165Bronchitis (HP:0012387)1.83800874
166Abnormal respiratory motile cilium morphology (HP:0005938)1.83632081
167Abnormal respiratory epithelium morphology (HP:0012253)1.83632081
168Abnormality of the heme biosynthetic pathway (HP:0010472)1.83511222
169Chronic diarrhea (HP:0002028)1.83028973
170Pustule (HP:0200039)1.82600404
171Neoplasm of the adrenal gland (HP:0100631)1.82434601
172Combined immunodeficiency (HP:0005387)1.81385679
173Acute myeloid leukemia (HP:0004808)1.81246062
174IgG deficiency (HP:0004315)1.81030827
175Abnormal delayed hypersensitivity skin test (HP:0002963)1.80794321
176Abnormality of chromosome stability (HP:0003220)1.80728261
177Progressive external ophthalmoplegia (HP:0000590)1.79152874
178Respiratory failure (HP:0002878)1.79068163
179B lymphocytopenia (HP:0010976)1.77776246
180Abnormality of B cell number (HP:0010975)1.77776246
181Pulmonary infiltrates (HP:0002113)1.77741328
182Epiphyseal dysplasia (HP:0002656)1.77430173
183Abnormality of transition element cation homeostasis (HP:0011030)1.76834748

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK3.53791215
2MAP4K13.42008952
3VRK22.75754472
4FLT32.70818928
5TTK2.67184877
6TXK2.56749503
7ZAK2.44581841
8TEC2.44309853
9TAF12.27062191
10MAP2K32.23370122
11TGFBR22.20924160
12KIT2.13308590
13NME22.07969951
14JAK32.04745455
15STK38L2.04158320
16STK101.99271822
17NEK11.98240469
18BTK1.92652487
19ZAP701.91909279
20TYK21.90074624
21TGFBR11.87861262
22ERN11.83826749
23TIE11.81053625
24PLK31.74131747
25BCKDK1.73406655
26MAP3K31.68922899
27CDK81.64262522
28IKBKE1.63228412
29ITK1.62144368
30TBK11.61010402
31MAP3K141.59666267
32MAP3K121.56697017
33FGFR41.49898813
34IRAK41.46727991
35TAOK31.45967691
36NME11.45190621
37EEF2K1.44167898
38PKN21.41010339
39WEE11.40650744
40CSF1R1.40287613
41KDR1.36953952
42BMPR1B1.35849678
43PASK1.33170425
44PIM11.31661514
45RPS6KB21.28897456
46IKBKB1.25231621
47NEK91.24140938
48RPS6KA41.22534564
49PIM21.20923834
50PIK3CG1.20544218
51NLK1.20347995
52TRIM281.19663884
53FGFR21.18789828
54OBSCN1.16941061
55CDK191.16466275
56IRAK31.13965576
57STK241.13840920
58PLK11.12993559
59MST41.11208544
60CDC71.10010274
61BMPR21.09235256
62MYLK1.09233541
63STK391.07995895
64VRK11.05104051
65LCK1.03409095
66SYK1.02779877
67CSK1.01350282
68PDK21.00647211
69OXSR10.98365271
70GRK60.97808677
71CHUK0.97333395
72BRSK20.96859414
73ACVR1B0.95865029
74LRRK20.91669188
75PRKG20.90976486
76CDK40.90817713
77EIF2AK10.88974258
78BLK0.88591551
79MAPK110.86712567
80SMG10.86506379
81EIF2AK30.86107612
82MAP3K60.85639224
83STK160.84469543
84GRK10.84183655
85LYN0.81811355
86JAK10.81355098
87DYRK30.79742149
88CDK70.79061578
89CDK60.78301524
90TSSK60.78093971
91NUAK10.77649484
92PINK10.76577062
93ATR0.72673218
94MAPKAPK30.70567630
95PLK20.69775874
96FGFR30.69121376
97ATM0.67149746
98HCK0.66484186
99CDK30.65897380
100FGFR10.65064798
101CDK90.64367624
102JAK20.63380394
103MAP3K20.63285218
104ALK0.62915065
105NEK20.61932785
106MKNK20.61805115
107MAP3K110.61446378
108DAPK10.61045520
109CSNK2A20.58701016
110MELK0.56730697
111TRPM70.55198425
112AURKB0.55141452
113MST1R0.55122807
114CHEK20.54514356
115FRK0.53912370
116CSNK1G10.53037954
117MAPK40.52979803
118STK40.52650763
119CHEK10.51475546
120EIF2AK20.48589183
121MAP3K40.47617668
122BUB10.47044344
123SRPK10.45885759
124CCNB10.45828978
125DAPK30.45301733
126PAK40.44024828
127MARK30.43595127
128MAP2K60.43273518
129RPS6KA50.42684411
130CSNK2A10.42572326
131MAPKAPK50.41610027
132MAP3K80.41536238
133BRSK10.41428560
134LATS10.40610835
135STK30.40594160
136RPS6KA60.40581509
137AKT20.38857069
138PLK40.38074437
139SCYL20.36504510
140ERBB30.35556858
141PTK60.35477467
142TNK20.35461272
143PRKAA20.35131047
144MAP3K100.34977026
145MAP3K130.33128168
146TNIK0.32456577
147MKNK10.32099692
148MAP3K50.32084204
149IGF1R0.31287144
150TLK10.31183701
151TESK20.31119110
152BCR0.26516396

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.58284621
2Caffeine metabolism_Homo sapiens_hsa002322.51508500
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.43037646
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.43022554
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.33475386
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.05313260
7One carbon pool by folate_Homo sapiens_hsa006701.91927304
8Primary immunodeficiency_Homo sapiens_hsa053401.91857551
9Mismatch repair_Homo sapiens_hsa034301.89167147
10Fatty acid elongation_Homo sapiens_hsa000621.88206444
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.82914581
12Drug metabolism - other enzymes_Homo sapiens_hsa009831.82796991
13Selenocompound metabolism_Homo sapiens_hsa004501.74533870
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72647476
15Vitamin B6 metabolism_Homo sapiens_hsa007501.63882594
16Folate biosynthesis_Homo sapiens_hsa007901.59710500
17Base excision repair_Homo sapiens_hsa034101.54312683
18Butanoate metabolism_Homo sapiens_hsa006501.53418127
19Ribosome_Homo sapiens_hsa030101.53208192
20Fatty acid degradation_Homo sapiens_hsa000711.52971312
21Complement and coagulation cascades_Homo sapiens_hsa046101.52908558
22Non-homologous end-joining_Homo sapiens_hsa034501.49252099
23Oxidative phosphorylation_Homo sapiens_hsa001901.45967737
24Tryptophan metabolism_Homo sapiens_hsa003801.43682100
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43504034
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38817722
27Staphylococcus aureus infection_Homo sapiens_hsa051501.37458247
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36528027
29Antigen processing and presentation_Homo sapiens_hsa046121.34440179
30Phenylalanine metabolism_Homo sapiens_hsa003601.34081777
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33582806
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.31832692
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31691190
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.31470639
35Peroxisome_Homo sapiens_hsa041461.30309955
36Other glycan degradation_Homo sapiens_hsa005111.29185944
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.29033212
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.24819926
39Pyrimidine metabolism_Homo sapiens_hsa002401.22925192
40Parkinsons disease_Homo sapiens_hsa050121.21602933
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21287483
42Measles_Homo sapiens_hsa051621.21176390
43Chemical carcinogenesis_Homo sapiens_hsa052041.20402358
44Homologous recombination_Homo sapiens_hsa034401.19422926
45Protein export_Homo sapiens_hsa030601.19048833
46NF-kappa B signaling pathway_Homo sapiens_hsa040641.17318546
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15194081
48Leishmaniasis_Homo sapiens_hsa051401.15030452
49Arginine and proline metabolism_Homo sapiens_hsa003301.14417412
50Tyrosine metabolism_Homo sapiens_hsa003501.14200235
51Hematopoietic cell lineage_Homo sapiens_hsa046401.12776056
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.12409456
53Intestinal immune network for IgA production_Homo sapiens_hsa046721.09100580
54Starch and sucrose metabolism_Homo sapiens_hsa005001.08175645
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.07977281
56Nucleotide excision repair_Homo sapiens_hsa034201.07058757
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05967052
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05845845
59Arginine biosynthesis_Homo sapiens_hsa002201.04266310
60Herpes simplex infection_Homo sapiens_hsa051681.02099622
61Legionellosis_Homo sapiens_hsa051341.00814243
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.00050316
63Propanoate metabolism_Homo sapiens_hsa006400.97803375
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.96574082
65Retinol metabolism_Homo sapiens_hsa008300.96162924
66Histidine metabolism_Homo sapiens_hsa003400.92403362
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.91857406
68Sulfur metabolism_Homo sapiens_hsa009200.90345076
69Purine metabolism_Homo sapiens_hsa002300.89683567
70Huntingtons disease_Homo sapiens_hsa050160.87271755
71beta-Alanine metabolism_Homo sapiens_hsa004100.87159352
72Pentose phosphate pathway_Homo sapiens_hsa000300.85970878
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85529239
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.83985848
75PPAR signaling pathway_Homo sapiens_hsa033200.83909159
76Spliceosome_Homo sapiens_hsa030400.80911032
77Systemic lupus erythematosus_Homo sapiens_hsa053220.80507671
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80478977
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80213979
80Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79885285
81ABC transporters_Homo sapiens_hsa020100.79769641
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78942651
83Sulfur relay system_Homo sapiens_hsa041220.78720406
84Metabolic pathways_Homo sapiens_hsa011000.78654676
85Cell cycle_Homo sapiens_hsa041100.77407756
86RNA polymerase_Homo sapiens_hsa030200.73403885
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.72485820
88T cell receptor signaling pathway_Homo sapiens_hsa046600.72349339
89RNA degradation_Homo sapiens_hsa030180.71314282
90Biosynthesis of amino acids_Homo sapiens_hsa012300.71010290
91Fat digestion and absorption_Homo sapiens_hsa049750.70862183
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70525470
93Fatty acid metabolism_Homo sapiens_hsa012120.70160485
94RNA transport_Homo sapiens_hsa030130.69621080
95Nitrogen metabolism_Homo sapiens_hsa009100.68984552
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.67326332
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67139772
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66704547
99p53 signaling pathway_Homo sapiens_hsa041150.66487231
100B cell receptor signaling pathway_Homo sapiens_hsa046620.66253906
101Osteoclast differentiation_Homo sapiens_hsa043800.66133497
102Glutathione metabolism_Homo sapiens_hsa004800.64582382
103Allograft rejection_Homo sapiens_hsa053300.64481908
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.64459862
105Pyruvate metabolism_Homo sapiens_hsa006200.63820724
106Proteasome_Homo sapiens_hsa030500.63589102
107NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63562457
108Vitamin digestion and absorption_Homo sapiens_hsa049770.63317723
109Steroid biosynthesis_Homo sapiens_hsa001000.61700504
110Graft-versus-host disease_Homo sapiens_hsa053320.60853908
111Carbon metabolism_Homo sapiens_hsa012000.60695992
112Alzheimers disease_Homo sapiens_hsa050100.59934620
113N-Glycan biosynthesis_Homo sapiens_hsa005100.59049724
114Galactose metabolism_Homo sapiens_hsa000520.58799326
115Type I diabetes mellitus_Homo sapiens_hsa049400.58509590
116Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58157359
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57542549
118Influenza A_Homo sapiens_hsa051640.56082287
119Basal transcription factors_Homo sapiens_hsa030220.52464365
120Fanconi anemia pathway_Homo sapiens_hsa034600.52103095
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51343552
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49938285
123Shigellosis_Homo sapiens_hsa051310.48997275
124Hepatitis B_Homo sapiens_hsa051610.47400708
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47074994
126Toxoplasmosis_Homo sapiens_hsa051450.47013892
127Lysine degradation_Homo sapiens_hsa003100.45220774
128Arachidonic acid metabolism_Homo sapiens_hsa005900.43632426
129mRNA surveillance pathway_Homo sapiens_hsa030150.41868470
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39862934
131Linoleic acid metabolism_Homo sapiens_hsa005910.38123307
132Fructose and mannose metabolism_Homo sapiens_hsa000510.37093347
133Renin-angiotensin system_Homo sapiens_hsa046140.32394579
134Asthma_Homo sapiens_hsa053100.29293351

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