NT5DC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin biosynthetic process (GO:0042438)9.53380798
2melanin metabolic process (GO:0006582)8.56389349
3secondary metabolite biosynthetic process (GO:0044550)8.31643352
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.84220492
5synaptic vesicle maturation (GO:0016188)5.76484691
6ketone body metabolic process (GO:1902224)5.61721787
7locomotory exploration behavior (GO:0035641)5.59718577
8retinal rod cell development (GO:0046548)5.52010237
9melanosome organization (GO:0032438)5.26561057
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.19669153
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.12883651
12vocalization behavior (GO:0071625)5.12745608
13pigment granule organization (GO:0048753)4.93057528
14glutamate secretion (GO:0014047)4.91456122
15synaptic vesicle exocytosis (GO:0016079)4.88792804
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.86138263
17regulation of glutamate receptor signaling pathway (GO:1900449)4.66430922
18developmental pigmentation (GO:0048066)4.52171721
19synaptic vesicle docking involved in exocytosis (GO:0016081)4.44467745
20G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.41678539
21layer formation in cerebral cortex (GO:0021819)4.41492364
22exploration behavior (GO:0035640)4.41087199
23regulation of synaptic vesicle exocytosis (GO:2000300)4.35810988
24ionotropic glutamate receptor signaling pathway (GO:0035235)4.24154167
25protein localization to synapse (GO:0035418)4.23406768
26regulation of neuronal synaptic plasticity (GO:0048168)4.19459086
27neurotransmitter secretion (GO:0007269)4.15209906
28proline transport (GO:0015824)4.10525674
29phenol-containing compound biosynthetic process (GO:0046189)4.08490388
30regulation of synapse structural plasticity (GO:0051823)4.06560403
31regulation of long-term neuronal synaptic plasticity (GO:0048169)4.06306305
32regulation of synaptic vesicle transport (GO:1902803)4.00593284
33melanosome transport (GO:0032402)3.95208147
34cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.92817871
35pigment cell differentiation (GO:0050931)3.91405123
36dendritic spine morphogenesis (GO:0060997)3.90525452
37respiratory chain complex IV assembly (GO:0008535)3.87868822
38melanocyte differentiation (GO:0030318)3.86196173
39neuronal action potential propagation (GO:0019227)3.85631908
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.83246046
41proteasome assembly (GO:0043248)3.80402503
42neuron cell-cell adhesion (GO:0007158)3.76550604
43pigment granule transport (GO:0051904)3.74025785
44glutamate receptor signaling pathway (GO:0007215)3.73998556
45establishment of melanosome localization (GO:0032401)3.73264719
46signal peptide processing (GO:0006465)3.72504592
47gamma-aminobutyric acid transport (GO:0015812)3.70388141
48activation of protein kinase A activity (GO:0034199)3.70090895
49cell communication by electrical coupling (GO:0010644)3.66811285
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.65558989
51synaptic transmission, glutamatergic (GO:0035249)3.65407469
52melanosome localization (GO:0032400)3.65013777
53regulation of hexokinase activity (GO:1903299)3.62025882
54regulation of glucokinase activity (GO:0033131)3.62025882
55long-term memory (GO:0007616)3.60440627
56sodium ion export (GO:0071436)3.60109648
57cellular potassium ion homeostasis (GO:0030007)3.59270064
58pigment biosynthetic process (GO:0046148)3.58824755
59establishment of pigment granule localization (GO:0051905)3.53957391
60positive regulation of protein autophosphorylation (GO:0031954)3.52017160
61positive regulation of synapse maturation (GO:0090129)3.51699651
62neurotransmitter-gated ion channel clustering (GO:0072578)3.49699785
63pigment granule localization (GO:0051875)3.47581073
64positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.45409651
65regulation of excitatory postsynaptic membrane potential (GO:0060079)3.43739963
66inositol phosphate catabolic process (GO:0071545)3.42013127
67cellular ketone body metabolic process (GO:0046950)3.40810614
68lactate metabolic process (GO:0006089)3.40438882
69response to pheromone (GO:0019236)3.40162906
70regulation of DNA endoreduplication (GO:0032875)3.36014657
71synaptic vesicle endocytosis (GO:0048488)3.34830014
72regulation of dendritic spine morphogenesis (GO:0061001)3.32507169
73neuron recognition (GO:0008038)3.31343372
74neuromuscular process controlling balance (GO:0050885)3.31285342
75replication fork processing (GO:0031297)3.30325295
76neurotransmitter transport (GO:0006836)3.29756072
77neuron-neuron synaptic transmission (GO:0007270)3.29738080
78dendrite morphogenesis (GO:0048813)3.29491067
79detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.28741232
80regulation of synaptic plasticity (GO:0048167)3.27525404
81positive regulation of membrane potential (GO:0045838)3.26534214
82protein K11-linked deubiquitination (GO:0035871)3.25974159
83regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.25710355
84positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.24730062
85regulation of postsynaptic membrane potential (GO:0060078)3.23422035
86synapsis (GO:0007129)3.23203634
87piRNA metabolic process (GO:0034587)3.22506912
88cytochrome complex assembly (GO:0017004)3.21509618
89endosome to melanosome transport (GO:0035646)3.17792322
90endosome to pigment granule transport (GO:0043485)3.17792322
91platelet dense granule organization (GO:0060155)3.13931520
92axonal fasciculation (GO:0007413)3.10054244
93regulation of ARF protein signal transduction (GO:0032012)3.09782258
94cerebellar Purkinje cell differentiation (GO:0021702)3.09472680
95membrane depolarization during action potential (GO:0086010)3.08965782
96regulation of integrin-mediated signaling pathway (GO:2001044)3.08671277
97pigment metabolic process (GO:0042440)3.08214186
98regulation of neurotransmitter levels (GO:0001505)3.05048304
99water-soluble vitamin biosynthetic process (GO:0042364)3.04421945
100regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.04391456
101regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.03059080
102transmission of nerve impulse (GO:0019226)3.01880510
103calcium-mediated signaling using intracellular calcium source (GO:0035584)3.01628472
104negative regulation of DNA-dependent DNA replication (GO:2000104)3.01366299
105cullin deneddylation (GO:0010388)2.99891769
106regulation of vesicle fusion (GO:0031338)2.98124526
107regulation of neurotransmitter secretion (GO:0046928)2.97524184
108protein complex biogenesis (GO:0070271)2.95297392
109cell communication involved in cardiac conduction (GO:0086065)2.95233553
110neuroepithelial cell differentiation (GO:0060563)2.94317285
111gamma-aminobutyric acid signaling pathway (GO:0007214)2.94302269
112G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.93775630
113regulation of acyl-CoA biosynthetic process (GO:0050812)2.92384328
114vesicle transport along microtubule (GO:0047496)2.91909269
115regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.91872962
116detection of calcium ion (GO:0005513)2.91360511
117DNA double-strand break processing (GO:0000729)2.91248373
118dendritic spine organization (GO:0097061)2.91155047
119plasma membrane repair (GO:0001778)2.90966741
120cell migration in hindbrain (GO:0021535)2.90800730
121polyol catabolic process (GO:0046174)2.90700786
122positive regulation of dendritic spine development (GO:0060999)2.90643734
123positive regulation of dendritic spine morphogenesis (GO:0061003)2.89986004
124innervation (GO:0060384)2.89442286
125postsynaptic membrane organization (GO:0001941)2.88443008
126protein K6-linked ubiquitination (GO:0085020)2.87696110
127mannosylation (GO:0097502)2.87329134
128membrane depolarization (GO:0051899)2.87272899
129tyrosine metabolic process (GO:0006570)2.87194057
130negative regulation of synaptic transmission, GABAergic (GO:0032229)2.86941533
131neuromuscular process controlling posture (GO:0050884)2.86626634
132cerebellar Purkinje cell layer development (GO:0021680)2.86235876
133positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.86215651
134negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.85858711
135long-term synaptic potentiation (GO:0060291)2.85752190
136social behavior (GO:0035176)2.83729977
137intraspecies interaction between organisms (GO:0051703)2.83729977
138mitochondrial respiratory chain complex assembly (GO:0033108)2.81094458
139positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.81053830
140regulation of dendritic spine development (GO:0060998)2.80701229
141potassium ion import (GO:0010107)2.80381940
142negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.80231040
143regulation of calcium ion transmembrane transporter activity (GO:1901019)2.79980027
144regulation of calcium ion transmembrane transport (GO:1903169)2.79980027
145organelle transport along microtubule (GO:0072384)2.79611345
146positive regulation of fibroblast migration (GO:0010763)2.78989197
147regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.78250391
148chemosensory behavior (GO:0007635)2.78025423
149auditory receptor cell stereocilium organization (GO:0060088)2.77659535
150regulation of synaptic transmission, glutamatergic (GO:0051966)2.76765797
151inositol phosphate dephosphorylation (GO:0046855)2.76590495
152phosphorylated carbohydrate dephosphorylation (GO:0046838)2.76590495
153glycine transport (GO:0015816)2.75977083
154positive regulation of potassium ion transmembrane transport (GO:1901381)2.75853103
155positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.72714846
156mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.72495628
157mitochondrial respiratory chain complex I assembly (GO:0032981)2.72495628
158NADH dehydrogenase complex assembly (GO:0010257)2.72495628
159neuromuscular process (GO:0050905)2.71897394
160establishment of nucleus localization (GO:0040023)2.71811991
161neuronal ion channel clustering (GO:0045161)2.70858857
162regulation of neurotransmitter uptake (GO:0051580)2.70810281
163L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.68742993
164DNA methylation involved in gamete generation (GO:0043046)2.67223750
165righting reflex (GO:0060013)2.66000191
166secondary metabolic process (GO:0019748)2.65989473
167double-strand break repair via homologous recombination (GO:0000724)2.62775815
168recombinational repair (GO:0000725)2.61478597
169photoreceptor cell development (GO:0042461)2.60335251
170regulation of sulfur metabolic process (GO:0042762)2.60196992
171protein deneddylation (GO:0000338)2.58999210
172regulation of meiosis I (GO:0060631)2.58693968
173regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.57039249
174somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.56249834
175somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.56249834
176isotype switching (GO:0045190)2.56249834
177prenylation (GO:0097354)2.55589734
178protein prenylation (GO:0018342)2.55589734
179pigmentation (GO:0043473)2.55237783
180DNA deamination (GO:0045006)2.52901720
181eye photoreceptor cell development (GO:0042462)2.51884514
182meiotic chromosome segregation (GO:0045132)2.51143511
183reciprocal meiotic recombination (GO:0007131)2.50499117
184reciprocal DNA recombination (GO:0035825)2.50499117
185regulation of coenzyme metabolic process (GO:0051196)2.48137969
186regulation of cofactor metabolic process (GO:0051193)2.48137969
187male meiosis (GO:0007140)2.47806605
188mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.47754252
189dopamine transport (GO:0015872)2.46934808
190positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.46251005
191keratinocyte development (GO:0003334)2.40434919
192RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.39910264
193preassembly of GPI anchor in ER membrane (GO:0016254)2.39850261
194anterograde synaptic vesicle transport (GO:0048490)2.37655809
195negative regulation of JUN kinase activity (GO:0043508)2.37512974
196regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.34178549
197non-recombinational repair (GO:0000726)2.33998094
198double-strand break repair via nonhomologous end joining (GO:0006303)2.33998094
199methionine biosynthetic process (GO:0009086)2.33394149

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.92517414
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.08168344
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.85890771
4VDR_22108803_ChIP-Seq_LS180_Human2.84727455
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.84427215
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77879013
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.75248735
8GBX2_23144817_ChIP-Seq_PC3_Human2.71162180
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.66704902
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.60252349
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57897121
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57897121
13DROSHA_22980978_ChIP-Seq_HELA_Human2.57487032
14REST_21632747_ChIP-Seq_MESCs_Mouse2.55688342
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.53482864
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.49590957
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42566601
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42143670
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.41957823
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38434876
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.36360971
22FUS_26573619_Chip-Seq_HEK293_Human2.35126071
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25737205
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23572128
25EZH2_27304074_Chip-Seq_ESCs_Mouse2.19667563
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.17339404
27EST1_17652178_ChIP-ChIP_JURKAT_Human2.15512248
28REST_18959480_ChIP-ChIP_MESCs_Mouse2.14812356
29EZH2_27294783_Chip-Seq_ESCs_Mouse2.14419807
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14237844
31SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10419142
32RNF2_27304074_Chip-Seq_ESCs_Mouse2.03716978
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.99031281
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.98341312
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.97091559
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.93407332
37ELK1_19687146_ChIP-ChIP_HELA_Human1.86401607
38EWS_26573619_Chip-Seq_HEK293_Human1.85634589
39AR_21572438_ChIP-Seq_LNCaP_Human1.85446139
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83387864
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81320904
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.80544005
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80253722
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72795897
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.69416556
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65222562
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63061820
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60637193
49BCAT_22108803_ChIP-Seq_LS180_Human1.57730130
50ER_23166858_ChIP-Seq_MCF-7_Human1.57504092
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56645356
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.54378691
53CBP_20019798_ChIP-Seq_JUKART_Human1.53445736
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53445736
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53066622
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52544398
57* EZH2_27294783_Chip-Seq_NPCs_Mouse1.52298861
58MYC_18940864_ChIP-ChIP_HL60_Human1.51375712
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.50191907
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49024720
61IGF1R_20145208_ChIP-Seq_DFB_Human1.46342658
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46153982
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.45957432
64* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45857105
65ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.44461013
66KDM2B_26808549_Chip-Seq_K562_Human1.43695941
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42291254
68* SMAD4_21799915_ChIP-Seq_A2780_Human1.41952701
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40054257
70ZNF274_21170338_ChIP-Seq_K562_Hela1.39497662
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39402886
72TCF4_22108803_ChIP-Seq_LS180_Human1.38002862
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36393856
74* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35718446
75E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35182510
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35080896
77VDR_23849224_ChIP-Seq_CD4+_Human1.34581893
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34439763
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33847636
80DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33808508
81RING1B_27294783_Chip-Seq_ESCs_Mouse1.33543518
82RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.33142094
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.32494626
84* CRX_20693478_ChIP-Seq_RETINA_Mouse1.31414869
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31311627
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.30416404
87CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29996051
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29564685
89* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28582416
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28438098
91WT1_25993318_ChIP-Seq_PODOCYTE_Human1.27782342
92TP53_22573176_ChIP-Seq_HFKS_Human1.26824919
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.26426781
94NANOG_19829295_ChIP-Seq_ESCs_Human1.26229142
95SOX2_19829295_ChIP-Seq_ESCs_Human1.26229142
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26022070
97AR_19668381_ChIP-Seq_PC3_Human1.25016848
98P53_22387025_ChIP-Seq_ESCs_Mouse1.24007485
99PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23783688
100ETS1_20019798_ChIP-Seq_JURKAT_Human1.23294029
101JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.23078014
102NOTCH1_21737748_ChIP-Seq_TLL_Human1.22117844
103* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21996940
104* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21805180
105PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21452169
106STAT3_18555785_Chip-Seq_ESCs_Mouse1.21302671
107* CDX2_22108803_ChIP-Seq_LS180_Human1.20219433
108AUTS2_25519132_ChIP-Seq_293T-REX_Human1.20136323
109SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.18474080
110E2F1_18555785_Chip-Seq_ESCs_Mouse1.18077942
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17414566
112TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17082854
113RING1B_27294783_Chip-Seq_NPCs_Mouse1.16416314
114FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16361936
115FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16338992
116* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16299896
117PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15721584
118EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13981118
119SOX2_18555785_Chip-Seq_ESCs_Mouse1.13484546
120FOXA1_25329375_ChIP-Seq_VCAP_Human1.12905475
121FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12905475
122FOXP3_21729870_ChIP-Seq_TREG_Human1.12564752
123RUNX2_22187159_ChIP-Seq_PCA_Human1.12157838
124KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11965468
125* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11396218
126SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10422880
127GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08918882
128HOXB7_26014856_ChIP-Seq_BT474_Human1.08709547
129SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08608813
130AR_25329375_ChIP-Seq_VCAP_Human1.08588314
131* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08212822
132P300_18555785_Chip-Seq_ESCs_Mouse1.07656903
133KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07501583
134SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07298238
135CMYC_18555785_Chip-Seq_ESCs_Mouse1.07091191
136ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05847058
137STAT3_23295773_ChIP-Seq_U87_Human1.05545909
138SMAD3_21741376_ChIP-Seq_EPCs_Human1.04105388
139EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04051965
140PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03917552
141RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03366986
142E2F7_22180533_ChIP-Seq_HELA_Human1.03140161
143EP300_21415370_ChIP-Seq_HL-1_Mouse1.02373617
144AHR_22903824_ChIP-Seq_MCF-7_Human1.01928705
145ARNT_22903824_ChIP-Seq_MCF-7_Human1.01395074
146YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01347758
147SMAD_19615063_ChIP-ChIP_OVARY_Human1.01325711
148SMAD4_21741376_ChIP-Seq_HESCs_Human1.01146848
149SMAD3_21741376_ChIP-Seq_HESCs_Human0.99908480
150THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99572144
151ESR1_20079471_ChIP-ChIP_T-47D_Human0.98737763
152TP53_16413492_ChIP-PET_HCT116_Human0.97389912
153ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97196571
154RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95142822
155* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94326276
156RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94308602
157CTCF_27219007_Chip-Seq_Bcells_Human0.93956236
158TET1_21490601_ChIP-Seq_MESCs_Mouse0.93104121
159* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92380144
160P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91744915
161TCF4_23295773_ChIP-Seq_U87_Human0.91525705
162PIAS1_25552417_ChIP-Seq_VCAP_Human0.90428211
163NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90297496
164P300_19829295_ChIP-Seq_ESCs_Human0.90231557
165MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90217193
166PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87946854
167TAF15_26573619_Chip-Seq_HEK293_Human0.86885067
168CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86249260
169RXR_22108803_ChIP-Seq_LS180_Human0.85529532
170DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.85364433
171SMAD3_21741376_ChIP-Seq_ESCs_Human0.85211486
172* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84924785
173TP53_20018659_ChIP-ChIP_R1E_Mouse0.84697608
174ESR2_21235772_ChIP-Seq_MCF-7_Human0.83478244
175LXR_22292898_ChIP-Seq_THP-1_Human0.82678357
176BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82335375
177* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.81604184
178AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.79868382
179CBX2_27304074_Chip-Seq_ESCs_Mouse0.79841937

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation7.92012394
2MP0004859_abnormal_synaptic_plasticity6.93476195
3MP0005075_abnormal_melanosome_morpholog4.91097503
4MP0005408_hypopigmentation4.78088484
5MP0005171_absent_coat_pigmentation4.26606660
6MP0003635_abnormal_synaptic_transmissio4.01130735
7MP0003880_abnormal_central_pattern3.74493562
8MP0004270_analgesia3.66946816
9MP0003136_yellow_coat_color3.63285629
10MP0000015_abnormal_ear_pigmentation3.62250036
11MP0002102_abnormal_ear_morphology3.60645807
12MP0002063_abnormal_learning/memory/cond3.16926474
13MP0009745_abnormal_behavioral_response3.15752317
14MP0002064_seizures2.89965426
15MP0002095_abnormal_skin_pigmentation2.86173692
16MP0005174_abnormal_tail_pigmentation2.84004585
17MP0000371_diluted_coat_color2.83347021
18MP0009046_muscle_twitch2.71612811
19MP0002572_abnormal_emotion/affect_behav2.52009314
20MP0001968_abnormal_touch/_nociception2.45236497
21MP0000751_myopathy2.42943015
22MP0005423_abnormal_somatic_nervous2.38467201
23MP0009780_abnormal_chondrocyte_physiolo2.37492359
24MP0002734_abnormal_mechanical_nocicepti2.35337837
25MP0001324_abnormal_eye_pigmentation2.33033912
26MP0004381_abnormal_hair_follicle2.26498160
27MP0002837_dystrophic_cardiac_calcinosis2.23507187
28MP0002272_abnormal_nervous_system2.19006966
29MP0002938_white_spotting2.15620900
30MP0001486_abnormal_startle_reflex2.09375971
31MP0003950_abnormal_plasma_membrane2.08457257
32MP0001440_abnormal_grooming_behavior2.07149760
33MP0004858_abnormal_nervous_system2.06890078
34MP0001501_abnormal_sleep_pattern2.05514573
35MP0002909_abnormal_adrenal_gland2.05193453
36MP0002735_abnormal_chemical_nociception1.99081633
37MP0004145_abnormal_muscle_electrophysio1.94264766
38MP0002822_catalepsy1.91962654
39MP0002733_abnormal_thermal_nociception1.88173166
40MP0008569_lethality_at_weaning1.85266597
41MP0003329_amyloid_beta_deposits1.84434681
42MP0005253_abnormal_eye_physiology1.83961262
43MP0003195_calcinosis1.74727378
44MP0005551_abnormal_eye_electrophysiolog1.74452069
45MP0001970_abnormal_pain_threshold1.73255502
46MP0002736_abnormal_nociception_after1.73069064
47MP0004811_abnormal_neuron_physiology1.70491867
48MP0002184_abnormal_innervation1.67225310
49MP0002067_abnormal_sensory_capabilities1.66891887
50MP0003878_abnormal_ear_physiology1.61845163
51MP0005377_hearing/vestibular/ear_phenot1.61845163
52MP0003646_muscle_fatigue1.57351338
53MP0000778_abnormal_nervous_system1.53174274
54MP0002075_abnormal_coat/hair_pigmentati1.53070418
55MP0005386_behavior/neurological_phenoty1.49906803
56MP0004924_abnormal_behavior1.49906803
57MP0002638_abnormal_pupillary_reflex1.49881340
58MP0002557_abnormal_social/conspecific_i1.48810714
59MP0004215_abnormal_myocardial_fiber1.46665229
60MP0008877_abnormal_DNA_methylation1.46317556
61MP0003879_abnormal_hair_cell1.45892193
62MP0000955_abnormal_spinal_cord1.45457741
63MP0010094_abnormal_chromosome_stability1.44234940
64MP0002877_abnormal_melanocyte_morpholog1.43599320
65MP0004130_abnormal_muscle_cell1.40146920
66MP0006276_abnormal_autonomic_nervous1.39525288
67MP0000427_abnormal_hair_cycle1.37363336
68MP0008058_abnormal_DNA_repair1.34642381
69MP0002066_abnormal_motor_capabilities/c1.34089380
70MP0004233_abnormal_muscle_weight1.33766930
71MP0003633_abnormal_nervous_system1.33628831
72MP0004510_myositis1.32763510
73MP0004885_abnormal_endolymph1.31832685
74MP0008961_abnormal_basal_metabolism1.31715838
75MP0003806_abnormal_nucleotide_metabolis1.27108946
76MP0008057_abnormal_DNA_replication1.26588332
77MP0000747_muscle_weakness1.25780780
78MP0002882_abnormal_neuron_morphology1.25501414
79MP0001186_pigmentation_phenotype1.22640177
80MP0004147_increased_porphyrin_level1.19244849
81MP0004484_altered_response_of1.16662374
82MP0003137_abnormal_impulse_conducting1.14331853
83MP0004085_abnormal_heartbeat1.13717864
84MP0003787_abnormal_imprinting1.10954471
85MP0000749_muscle_degeneration1.10566751
86MP0000013_abnormal_adipose_tissue1.09294732
87MP0003631_nervous_system_phenotype1.08914782
88MP0006072_abnormal_retinal_apoptosis1.08408232
89MP0005646_abnormal_pituitary_gland1.07657197
90MP0004036_abnormal_muscle_relaxation1.06837925
91MP0001502_abnormal_circadian_rhythm1.06700088
92MP0005379_endocrine/exocrine_gland_phen1.06524729
93MP0004087_abnormal_muscle_fiber1.05623404
94MP0002876_abnormal_thyroid_physiology1.03609070
95MP0005623_abnormal_meninges_morphology1.02871411
96MP0000569_abnormal_digit_pigmentation1.02810231
97MP0005645_abnormal_hypothalamus_physiol1.02160276
98MP0005620_abnormal_muscle_contractility1.00915182
99MP0006036_abnormal_mitochondrial_physio0.99543590
100MP0002152_abnormal_brain_morphology0.99396761
101MP0001984_abnormal_olfaction0.98906769
102MP0000647_abnormal_sebaceous_gland0.97941089
103MP0002106_abnormal_muscle_physiology0.97763763
104MP0003283_abnormal_digestive_organ0.97249395
105MP0003718_maternal_effect0.95812917
106MP0008874_decreased_physiological_sensi0.95498339
107MP0004142_abnormal_muscle_tone0.95093135
108MP0002269_muscular_atrophy0.94485134
109MP0003075_altered_response_to0.94184013
110MP0005197_abnormal_uvea_morphology0.93005681
111MP0003122_maternal_imprinting0.92565575
112MP0000759_abnormal_skeletal_muscle0.92007475
113MP0004084_abnormal_cardiac_muscle0.91745206
114MP0005535_abnormal_body_temperature0.91666894
115MP0003786_premature_aging0.90822547
116MP0005330_cardiomyopathy0.89652238
117MP0005257_abnormal_intraocular_pressure0.88952744
118MP0001986_abnormal_taste_sensitivity0.88633619
119MP0002234_abnormal_pharynx_morphology0.88336428
120MP0001485_abnormal_pinna_reflex0.87719216
121MP0004133_heterotaxia0.87380779
122MP0005248_abnormal_Harderian_gland0.85207219
123MP0002069_abnormal_eating/drinking_beha0.84619917
124MP0005369_muscle_phenotype0.84352274
125MP0001905_abnormal_dopamine_level0.84216823
126MP0003890_abnormal_embryonic-extraembry0.81096951
127MP0002163_abnormal_gland_morphology0.80306207
128MP0000604_amyloidosis0.80225124
129MP0003634_abnormal_glial_cell0.76717958
130MP0002229_neurodegeneration0.75937597
131MP0008872_abnormal_physiological_respon0.74595581
132MP0002972_abnormal_cardiac_muscle0.74409336
133MP0003172_abnormal_lysosome_physiology0.74366046
134MP0003632_abnormal_nervous_system0.73087992
135MP0002090_abnormal_vision0.72210671
136MP0010386_abnormal_urinary_bladder0.71288076
137MP0003045_fibrosis0.70062961
138MP0001299_abnormal_eye_distance/0.68884064
139MP0001177_atelectasis0.68729751
140MP0002160_abnormal_reproductive_system0.68135538
141MP0010678_abnormal_skin_adnexa0.67883912
142MP0005391_vision/eye_phenotype0.66927465
143MP0003690_abnormal_glial_cell0.65703851
144MP0005187_abnormal_penis_morphology0.64790123
145MP0003943_abnormal_hepatobiliary_system0.64515304
146MP0003186_abnormal_redox_activity0.64456212
147MP0000383_abnormal_hair_follicle0.62197325
148MP0004043_abnormal_pH_regulation0.61337319
149MP0005332_abnormal_amino_acid0.59956272
150MP0000631_abnormal_neuroendocrine_gland0.58869749
151MP0000538_abnormal_urinary_bladder0.58257469
152MP0002177_abnormal_outer_ear0.57581472
153MP0005389_reproductive_system_phenotype0.57190563
154MP0005167_abnormal_blood-brain_barrier0.56958263
155MP0001348_abnormal_lacrimal_gland0.55225901
156MP0001963_abnormal_hearing_physiology0.54799895
157MP0008875_abnormal_xenobiotic_pharmacok0.54023041
158MP0001944_abnormal_pancreas_morphology0.53546641
159MP0005195_abnormal_posterior_eye0.52107730
160MP0001929_abnormal_gametogenesis0.51959888
161MP0002210_abnormal_sex_determination0.45442069

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.47303789
2Congenital stationary night blindness (HP:0007642)6.31614471
3Ocular albinism (HP:0001107)6.18727215
4Iris hypopigmentation (HP:0007730)5.94581147
5Aplasia/Hypoplasia of the macula (HP:0008059)5.88242589
6Myokymia (HP:0002411)5.69568328
7Aplasia/Hypoplasia affecting the retina (HP:0008061)5.44723232
8Aplasia/Hypoplasia of the fovea (HP:0008060)5.17197133
9Hypoplasia of the fovea (HP:0007750)5.17197133
10Visual hallucinations (HP:0002367)5.03906606
11Focal seizures (HP:0007359)5.03822154
12Decreased central vision (HP:0007663)4.56858525
13Abnormality of the fovea (HP:0000493)4.49136134
14Blue irides (HP:0000635)4.38273059
15Generalized hypopigmentation (HP:0007513)3.96312290
16Atonic seizures (HP:0010819)3.96072394
17Epileptic encephalopathy (HP:0200134)3.85035016
18Progressive cerebellar ataxia (HP:0002073)3.80758386
19Patchy hypopigmentation of hair (HP:0011365)3.74243300
20Absence seizures (HP:0002121)3.72200977
21Febrile seizures (HP:0002373)3.69335447
22Albinism (HP:0001022)3.58184290
23Generalized tonic-clonic seizures (HP:0002069)3.53732941
24Action tremor (HP:0002345)3.53199172
25Exercise-induced myalgia (HP:0003738)3.42148104
26Dialeptic seizures (HP:0011146)3.41585669
27White forelock (HP:0002211)3.33827841
28Intestinal atresia (HP:0011100)3.32110720
29Impaired vibration sensation in the lower limbs (HP:0002166)3.29560871
30Supranuclear gaze palsy (HP:0000605)3.28040894
31Abnormality of the lower motor neuron (HP:0002366)3.26290168
32Poor eye contact (HP:0000817)3.18936215
33Ankle clonus (HP:0011448)3.08540248
34Abnormal social behavior (HP:0012433)3.04542781
35Impaired social interactions (HP:0000735)3.04542781
36Papilledema (HP:0001085)3.02346213
37Bundle branch block (HP:0011710)2.99848890
38Horizontal nystagmus (HP:0000666)2.99338687
39Depression (HP:0000716)2.94675002
40Sudden death (HP:0001699)2.94536833
41Hypopigmentation of the fundus (HP:0007894)2.94092209
42Broad-based gait (HP:0002136)2.92915164
43Urinary bladder sphincter dysfunction (HP:0002839)2.91041004
44Acute encephalopathy (HP:0006846)2.90550656
45Dysdiadochokinesis (HP:0002075)2.88765906
46Postural instability (HP:0002172)2.86239442
47Generalized hypopigmentation of hair (HP:0011358)2.85855797
48Ventricular fibrillation (HP:0001663)2.83668690
49Increased CSF lactate (HP:0002490)2.80985790
50Freckling (HP:0001480)2.80582457
51Acute necrotizing encephalopathy (HP:0006965)2.80108608
52Large for gestational age (HP:0001520)2.77566970
53Dysmetria (HP:0001310)2.76136352
54Mutism (HP:0002300)2.74364687
55Progressive macrocephaly (HP:0004481)2.73647811
56Urinary urgency (HP:0000012)2.70912382
57Genetic anticipation (HP:0003743)2.68084115
58Neoplasm of the adrenal cortex (HP:0100641)2.64404671
59Amblyopia (HP:0000646)2.63857635
60Volvulus (HP:0002580)2.62256773
61Hyperventilation (HP:0002883)2.61987990
62Dysmetric saccades (HP:0000641)2.61658648
63Anxiety (HP:0000739)2.56934896
64Cerebral inclusion bodies (HP:0100314)2.53724754
65Pancreatic cysts (HP:0001737)2.53202089
66Congenital sensorineural hearing impairment (HP:0008527)2.53082875
67Gaze-evoked nystagmus (HP:0000640)2.50170991
68Mitochondrial inheritance (HP:0001427)2.49896544
69Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.48839034
70Difficulty running (HP:0009046)2.46535443
71Lower limb amyotrophy (HP:0007210)2.46446001
72Drooling (HP:0002307)2.46178483
73Excessive salivation (HP:0003781)2.46178483
74Abnormality of glycolysis (HP:0004366)2.42826792
75Exercise-induced muscle cramps (HP:0003710)2.42703925
76Truncal ataxia (HP:0002078)2.41909321
77Muscle hypertrophy of the lower extremities (HP:0008968)2.41640596
78Calf muscle hypertrophy (HP:0008981)2.39692798
79Abnormal mitochondria in muscle tissue (HP:0008316)2.39351330
80Myotonia (HP:0002486)2.38311814
81Hemiplegia (HP:0002301)2.35352010
82Molar tooth sign on MRI (HP:0002419)2.34044815
83Abnormality of midbrain morphology (HP:0002418)2.34044815
84Hypothermia (HP:0002045)2.33185725
85Termporal pattern (HP:0011008)2.33107379
86Insidious onset (HP:0003587)2.33107379
87Hepatocellular necrosis (HP:0001404)2.30811523
88Cutaneous melanoma (HP:0012056)2.29979576
89Pancreatic fibrosis (HP:0100732)2.27814960
90Rapidly progressive (HP:0003678)2.26980762
91True hermaphroditism (HP:0010459)2.26778569
92Impaired smooth pursuit (HP:0007772)2.24957486
93Epileptiform EEG discharges (HP:0011182)2.24662423
94Fetal akinesia sequence (HP:0001989)2.24461876
95Hemiparesis (HP:0001269)2.24136780
96Abnormal eating behavior (HP:0100738)2.23698159
97Bradykinesia (HP:0002067)2.21271281
98Progressive inability to walk (HP:0002505)2.20852253
99Intention tremor (HP:0002080)2.20223327
100Abnormality of the corticospinal tract (HP:0002492)2.19280234
101Abnormality of the calf musculature (HP:0001430)2.18903591
102Syncope (HP:0001279)2.18813050
103Spastic gait (HP:0002064)2.18807067
104EEG with generalized epileptiform discharges (HP:0011198)2.18776048
105Astigmatism (HP:0000483)2.18724277
106Diplopia (HP:0000651)2.16030451
107Abnormality of binocular vision (HP:0011514)2.16030451
108Impaired vibratory sensation (HP:0002495)2.15690072
109Hepatic necrosis (HP:0002605)2.14458386
110Type II lissencephaly (HP:0007260)2.13919284
111Status epilepticus (HP:0002133)2.13877483
112Neurofibrillary tangles (HP:0002185)2.13527718
113Hypsarrhythmia (HP:0002521)2.12938598
114Lower limb muscle weakness (HP:0007340)2.12140635
115Increased hepatocellular lipid droplets (HP:0006565)2.09989459
116Abnormal EKG (HP:0003115)2.07870455
117Lipid accumulation in hepatocytes (HP:0006561)2.07456462
118Torticollis (HP:0000473)2.06524047
119Hyporeflexia of lower limbs (HP:0002600)2.05830810
120Tongue fasciculations (HP:0001308)2.04628810
121Amyotrophic lateral sclerosis (HP:0007354)2.04176067
122Insomnia (HP:0100785)2.02609584
123EMG: myopathic abnormalities (HP:0003458)2.02116495
124Abnormal auditory evoked potentials (HP:0006958)2.01751112
125Neoplasm of the adrenal gland (HP:0100631)2.01404921
126Stereotypic behavior (HP:0000733)2.00576010
127Abnormality of macular pigmentation (HP:0008002)2.00081144
128Agitation (HP:0000713)1.99764019
129Abnormality of ocular smooth pursuit (HP:0000617)1.99361206
130Abnormality of the renal cortex (HP:0011035)1.98696492
131Focal dystonia (HP:0004373)1.95897166
132Difficulty climbing stairs (HP:0003551)1.95867633
133Ketoacidosis (HP:0001993)1.95493999
1343-Methylglutaconic aciduria (HP:0003535)1.95473431
135Hypokinesia (HP:0002375)1.95440875
136Pheochromocytoma (HP:0002666)1.95046700
137Increased variability in muscle fiber diameter (HP:0003557)1.93516718
138Gastrointestinal atresia (HP:0002589)1.93274576
139Achilles tendon contracture (HP:0001771)1.92896311
140Adrenal hypoplasia (HP:0000835)1.92844265
141Hamartoma of the eye (HP:0010568)1.92773648
142Primary atrial arrhythmia (HP:0001692)1.92492959
143Ventricular arrhythmia (HP:0004308)1.91572418
144Prolonged QT interval (HP:0001657)1.90867573
145Generalized myoclonic seizures (HP:0002123)1.90141846
146Abnormality of chromosome stability (HP:0003220)1.89466059
147Methylmalonic acidemia (HP:0002912)1.88308987
148Megalencephaly (HP:0001355)1.88279986
149Type I transferrin isoform profile (HP:0003642)1.86995795
150Absent speech (HP:0001344)1.84877741
151EMG: neuropathic changes (HP:0003445)1.83758728
152Atrial fibrillation (HP:0005110)1.82620746
153Annular pancreas (HP:0001734)1.82311225
154Pointed chin (HP:0000307)1.82052110
155Abnormality of vitamin B metabolism (HP:0004340)1.81590805
156Scanning speech (HP:0002168)1.81549199
157Obstructive sleep apnea (HP:0002870)1.81124087
158Ependymoma (HP:0002888)1.80550540
159Increased serum lactate (HP:0002151)1.79289534
160Abnormality of methionine metabolism (HP:0010901)1.78204714
161Small hand (HP:0200055)1.78075793
162Nephronophthisis (HP:0000090)1.77838584
163Heart block (HP:0012722)1.77611500
164Methylmalonic aciduria (HP:0012120)1.76863864
165Abnormality of the Achilles tendon (HP:0005109)1.76650269
166Premature graying of hair (HP:0002216)1.76061034
167Respiratory failure (HP:0002878)1.71976601
168Chromsome breakage (HP:0040012)1.69994522
169Increased serum pyruvate (HP:0003542)1.69203284
170Diminished movement (HP:0002374)1.68708743
171Astrocytoma (HP:0009592)1.68361888
172Abnormality of the astrocytes (HP:0100707)1.68361888
173Aplasia/Hypoplasia of the uvula (HP:0010293)1.68037231
174Abnormality of aspartate family amino acid metabolism (HP:0010899)1.67480392
175Renal Fanconi syndrome (HP:0001994)1.67110624
176Cerebral edema (HP:0002181)1.66211131
177Tubular atrophy (HP:0000092)1.66182397
178Abnormal protein glycosylation (HP:0012346)1.65218367
179Abnormal glycosylation (HP:0012345)1.65218367
180Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.65218367
181Abnormal protein N-linked glycosylation (HP:0012347)1.65218367
182Renal cortical cysts (HP:0000803)1.63100359
183Aplasia/Hypoplasia of the tibia (HP:0005772)1.62802260
184Chronic hepatic failure (HP:0100626)1.61846432
185Fair hair (HP:0002286)1.59363459
186Pancreatic islet-cell hyperplasia (HP:0004510)1.58157329
187Abnormal drinking behavior (HP:0030082)1.57746519
188Polydipsia (HP:0001959)1.57746519
189Abnormality of the renal medulla (HP:0100957)1.57175939
190Abnormality of the ileum (HP:0001549)1.56367655
191Muscle fibrillation (HP:0010546)1.55688292
192Lactic acidosis (HP:0003128)1.53923498
193Furrowed tongue (HP:0000221)1.53857083
194Pendular nystagmus (HP:0012043)1.53800220
195Hyperglycemia (HP:0003074)1.53283615

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.10009515
2NTRK34.27267122
3MAP3K93.90232684
4MARK13.42225284
5BMPR1B3.31738569
6EPHA42.98338699
7MAP4K22.90712651
8MAP3K42.87032616
9TRIM282.84105033
10WEE12.64590973
11EIF2AK12.59430490
12ACVR1B2.53841178
13PDK22.44817840
14EIF2AK32.44734568
15MINK12.44122358
16PRKD32.35956019
17PAK62.33493558
18PHKG12.23503120
19PHKG22.23503120
20DAPK22.17559432
21KSR22.15855079
22MST42.13628291
23ERBB32.05281748
24MAP2K42.03637675
25MAP2K72.00422597
26MKNK21.97146480
27NTRK21.90790789
28NTRK11.82480998
29WNK31.76947735
30CAMKK11.76119210
31NUAK11.72076652
32GRK11.71999298
33PLK31.64723625
34STK381.61717003
35LATS21.58453974
36STK38L1.54858743
37BRSK21.48827553
38SIK21.45823595
39GRK51.44860014
40ZAK1.41013234
41CDK51.40770320
42KSR11.35764509
43TYRO31.33567598
44MAP3K21.29920847
45STK391.29826186
46MUSK1.29399285
47ADRBK21.28102071
48DAPK11.24589287
49MST1R1.23762714
50PNCK1.22379374
51FGFR21.21923965
52MARK31.19748888
53CSNK1G11.17406474
54LMTK21.15510423
55MAP3K121.15204481
56PAK31.12242411
57UHMK11.10323614
58DMPK1.08913537
59PRKCG1.08233409
60TAOK11.07978064
61ALK1.07797847
62BUB11.07753984
63WNK41.07704893
64STK31.06491150
65PLK21.06243214
66RIPK11.04796492
67MAP3K71.04227182
68PINK11.03890889
69TRIB31.02075317
70RIPK41.01624711
71INSRR1.00540456
72PRKCH1.00352840
73DDR20.98283732
74CSNK1G30.97891852
75MAPK130.97402037
76RET0.96549010
77CAMK2A0.95270406
78TTN0.95096363
79MKNK10.93910995
80CAMK10.92587409
81PLK40.92521560
82FES0.92423143
83CSNK1A1L0.90497438
84STK110.89274107
85TSSK60.89006874
86NME10.88374738
87PRPF4B0.87137974
88MARK20.85964102
89OXSR10.85679697
90ADRBK10.83743268
91PLK10.82704654
92MAP3K130.80287528
93TNIK0.79500574
94SIK30.79063836
95ERBB40.77748688
96MYLK0.77623249
97PDGFRA0.77481405
98PTK2B0.76426408
99CDC42BPA0.76119193
100BMPR20.75899500
101CDK150.73555488
102ARAF0.73377289
103RAF10.73053953
104PDK10.72105005
105CDK180.71285440
106PRKAA20.70731066
107MAP3K10.70333524
108SGK10.69448292
109PRKCI0.69116904
110CDK140.68948207
111CAMK2B0.68507526
112MAPKAPK30.68112054
113CAMK1G0.67851132
114BCR0.65913891
115SGK30.65810936
116MAP3K60.63419494
117PDPK10.63410140
118PKN20.62868815
119MET0.62819411
120BRSK10.62374430
121CDK11A0.61677294
122TTK0.61523024
123FER0.61263741
124PBK0.61227038
125MAPK120.60144836
126ATM0.59778721
127ICK0.59673895
128NEK10.59564081
129ATR0.59500750
130GSK3A0.58091545
131AKT30.55844398
132DYRK1A0.55279059
133CSNK1G20.54774751
134CAMKK20.54507270
135CAMK40.54498750
136TGFBR10.54012931
137RPS6KA30.53998907
138SGK2230.53839653
139SGK4940.53839653
140PDK30.52942101
141PDK40.52942101
142SCYL20.52096355
143CAMK2D0.51937837
144SGK20.50534028
145EIF2AK20.49393800
146OBSCN0.49392833
147MAP2K10.49359288
148WNK10.48694282
149FGR0.48175834
150CSNK1D0.47944232
151FGFR10.46435664
152PRKCZ0.46049618
153CDC70.46008009
154CAMK2G0.45771344
155RPS6KA20.44083623
156CCNB10.43754885
157BMX0.43240718
158PRKCE0.43124631
159CASK0.42605858
160CLK10.42056321
161FYN0.42027221
162STK160.40625476
163AKT20.40317921
164MAP3K30.38693138
165VRK10.37665734
166PRKAA10.36813766
167CSNK1A10.36767958
168CHEK20.36762221
169TRPM70.36099363
170SRPK10.34735123
171LIMK10.34713409
172MAP2K60.32169311

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.34204855
2Nicotine addiction_Homo sapiens_hsa050333.11946376
3Non-homologous end-joining_Homo sapiens_hsa034502.90599656
4Synaptic vesicle cycle_Homo sapiens_hsa047212.75611919
5Proteasome_Homo sapiens_hsa030502.75605714
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.64000627
7Long-term potentiation_Homo sapiens_hsa047202.50195142
8Circadian entrainment_Homo sapiens_hsa047132.45314477
9GABAergic synapse_Homo sapiens_hsa047272.42606776
10Homologous recombination_Homo sapiens_hsa034402.35804663
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.31755383
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.30863214
13Olfactory transduction_Homo sapiens_hsa047402.28778133
14Glutamatergic synapse_Homo sapiens_hsa047242.27847622
15Oxidative phosphorylation_Homo sapiens_hsa001902.25420805
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.23453272
17Propanoate metabolism_Homo sapiens_hsa006402.20908504
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.20063666
19Amphetamine addiction_Homo sapiens_hsa050312.16272608
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.09613112
21Morphine addiction_Homo sapiens_hsa050322.04490621
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.00761391
23Insulin secretion_Homo sapiens_hsa049112.00245538
24Salivary secretion_Homo sapiens_hsa049701.94603838
25Basal transcription factors_Homo sapiens_hsa030221.93186543
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.93130844
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.90905424
28Dopaminergic synapse_Homo sapiens_hsa047281.87579224
29Gastric acid secretion_Homo sapiens_hsa049711.87155281
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.82439845
31Selenocompound metabolism_Homo sapiens_hsa004501.81951075
32Fanconi anemia pathway_Homo sapiens_hsa034601.80488777
33Cholinergic synapse_Homo sapiens_hsa047251.75710302
34Parkinsons disease_Homo sapiens_hsa050121.74290925
35Oxytocin signaling pathway_Homo sapiens_hsa049211.71915084
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.64761202
37RNA polymerase_Homo sapiens_hsa030201.61683104
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.61205143
39Vitamin B6 metabolism_Homo sapiens_hsa007501.59896456
40GnRH signaling pathway_Homo sapiens_hsa049121.55475639
41Calcium signaling pathway_Homo sapiens_hsa040201.52734050
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.51255709
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.51158283
44Long-term depression_Homo sapiens_hsa047301.50475872
45Taste transduction_Homo sapiens_hsa047421.49773688
46Sulfur metabolism_Homo sapiens_hsa009201.48631395
47One carbon pool by folate_Homo sapiens_hsa006701.47655832
48Renin secretion_Homo sapiens_hsa049241.47294830
49Phototransduction_Homo sapiens_hsa047441.44750272
50Nitrogen metabolism_Homo sapiens_hsa009101.43368824
51Type II diabetes mellitus_Homo sapiens_hsa049301.42043816
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39058362
53RNA degradation_Homo sapiens_hsa030181.36599546
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35008591
55Serotonergic synapse_Homo sapiens_hsa047261.33335925
56Cocaine addiction_Homo sapiens_hsa050301.32349947
57Tryptophan metabolism_Homo sapiens_hsa003801.29521113
58Gap junction_Homo sapiens_hsa045401.28141114
59Dilated cardiomyopathy_Homo sapiens_hsa054141.28073721
60Estrogen signaling pathway_Homo sapiens_hsa049151.26702530
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23397762
62Glioma_Homo sapiens_hsa052141.22604120
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21464095
64Cardiac muscle contraction_Homo sapiens_hsa042601.20942061
65cAMP signaling pathway_Homo sapiens_hsa040241.19433627
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17723180
67Huntingtons disease_Homo sapiens_hsa050161.15926068
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.13084213
69cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12045967
70Tyrosine metabolism_Homo sapiens_hsa003501.11553509
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10506356
72Alzheimers disease_Homo sapiens_hsa050101.09214634
73Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07817116
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06411233
75Fatty acid elongation_Homo sapiens_hsa000621.06031713
76ErbB signaling pathway_Homo sapiens_hsa040121.04880376
77RNA transport_Homo sapiens_hsa030131.02044138
78Dorso-ventral axis formation_Homo sapiens_hsa043201.01608949
79beta-Alanine metabolism_Homo sapiens_hsa004101.00943321
80Melanogenesis_Homo sapiens_hsa049160.99331753
81Axon guidance_Homo sapiens_hsa043600.97914853
82Pyruvate metabolism_Homo sapiens_hsa006200.97287578
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.97161069
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95732582
85Linoleic acid metabolism_Homo sapiens_hsa005910.94035781
86Peroxisome_Homo sapiens_hsa041460.93799225
87Glucagon signaling pathway_Homo sapiens_hsa049220.93056571
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.92201990
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.91445799
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91135563
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89428368
92Collecting duct acid secretion_Homo sapiens_hsa049660.89327177
93Fatty acid degradation_Homo sapiens_hsa000710.88650532
94Nucleotide excision repair_Homo sapiens_hsa034200.87316308
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86354552
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86115263
97Caffeine metabolism_Homo sapiens_hsa002320.85219414
98Ether lipid metabolism_Homo sapiens_hsa005650.85118110
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.84559560
100mTOR signaling pathway_Homo sapiens_hsa041500.84540419
101Metabolic pathways_Homo sapiens_hsa011000.83100996
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80302589
103Fatty acid metabolism_Homo sapiens_hsa012120.79858853
104Mismatch repair_Homo sapiens_hsa034300.79734446
105Sphingolipid metabolism_Homo sapiens_hsa006000.79338377
106VEGF signaling pathway_Homo sapiens_hsa043700.79273848
107Glutathione metabolism_Homo sapiens_hsa004800.79023863
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77269213
109Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75888151
110Insulin signaling pathway_Homo sapiens_hsa049100.75725690
111Choline metabolism in cancer_Homo sapiens_hsa052310.75720423
112Pancreatic secretion_Homo sapiens_hsa049720.75361513
113MAPK signaling pathway_Homo sapiens_hsa040100.74246563
114Folate biosynthesis_Homo sapiens_hsa007900.73766389
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73520761
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72998774
117Histidine metabolism_Homo sapiens_hsa003400.72695366
118Purine metabolism_Homo sapiens_hsa002300.72489798
119Thyroid hormone synthesis_Homo sapiens_hsa049180.72104017
120Steroid biosynthesis_Homo sapiens_hsa001000.71821505
121Bile secretion_Homo sapiens_hsa049760.71417774
122Regulation of autophagy_Homo sapiens_hsa041400.71042376
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.69916883
124Chemical carcinogenesis_Homo sapiens_hsa052040.68241510
125Circadian rhythm_Homo sapiens_hsa047100.67930855
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67515443
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65958549
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65325925
129Oocyte meiosis_Homo sapiens_hsa041140.65092974
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65057596
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64316136
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63968137
133Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62437121
134Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62396423
135Pyrimidine metabolism_Homo sapiens_hsa002400.62044579
136Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60191111
137Arginine biosynthesis_Homo sapiens_hsa002200.59465735
138Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57855383
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56804111
140Vibrio cholerae infection_Homo sapiens_hsa051100.55974827
141Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54365496
142Rap1 signaling pathway_Homo sapiens_hsa040150.54333215
143Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54251533
144Lysine degradation_Homo sapiens_hsa003100.53917249
145p53 signaling pathway_Homo sapiens_hsa041150.53340095
146Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53092868
147Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52047105
148Ras signaling pathway_Homo sapiens_hsa040140.51931347
1492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51596761
150ABC transporters_Homo sapiens_hsa020100.51183120
151Endometrial cancer_Homo sapiens_hsa052130.50604867
152Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49928307
153Mineral absorption_Homo sapiens_hsa049780.49205477
154Butanoate metabolism_Homo sapiens_hsa006500.49067607
155Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49051993
156Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49020625
157Cell cycle_Homo sapiens_hsa041100.47777500
158Arginine and proline metabolism_Homo sapiens_hsa003300.47745118
159Retinol metabolism_Homo sapiens_hsa008300.47735406
160Renal cell carcinoma_Homo sapiens_hsa052110.46746825
161Prion diseases_Homo sapiens_hsa050200.45993190
162Fatty acid biosynthesis_Homo sapiens_hsa000610.45516379
163Endocytosis_Homo sapiens_hsa041440.45366537
164Inositol phosphate metabolism_Homo sapiens_hsa005620.45235467
165Non-small cell lung cancer_Homo sapiens_hsa052230.44832182
166Adipocytokine signaling pathway_Homo sapiens_hsa049200.42866493
167AMPK signaling pathway_Homo sapiens_hsa041520.42062365
168Sphingolipid signaling pathway_Homo sapiens_hsa040710.41813209
169Central carbon metabolism in cancer_Homo sapiens_hsa052300.41151393
170Insulin resistance_Homo sapiens_hsa049310.40697632
171Steroid hormone biosynthesis_Homo sapiens_hsa001400.40485113
172Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39099815
173Wnt signaling pathway_Homo sapiens_hsa043100.38925913
174Glycerolipid metabolism_Homo sapiens_hsa005610.38869357
175Type I diabetes mellitus_Homo sapiens_hsa049400.38222110
176Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38107616
177Ovarian steroidogenesis_Homo sapiens_hsa049130.37622664
178Tight junction_Homo sapiens_hsa045300.37570920
179Prolactin signaling pathway_Homo sapiens_hsa049170.35607039
180Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35030871

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