ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm motility (GO:0030317)	9.82212705
2	chromosome condensation (GO:0030261)	9.67160098
3	DNA packaging (GO:0006323)	9.19100104
4	microtubule depolymerization (GO:0007019)	9.16847700
5	sperm capacitation (GO:0048240)	8.19450517
6	spermatid nucleus differentiation (GO:0007289)	7.85211376
7	plasma membrane fusion (GO:0045026)	7.62267751
8	spermatid development (GO:0007286)	7.14564546
9	response to pheromone (GO:0019236)	7.12481840
10	microtubule polymerization or depolymerization (GO:0031109)	7.02278693
11	sperm-egg recognition (GO:0035036)	6.85225300
12	single strand break repair (GO:0000012)	6.79411119
13	multicellular organism reproduction (GO:0032504)	6.30980362
14	centriole replication (GO:0007099)	6.29027909
15	binding of sperm to zona pellucida (GO:0007339)	6.27562766
16	phosphatidylethanolamine biosynthetic process (GO:0006646)	6.00397506
17	reproduction (GO:0000003)	5.80025566
18	cell-cell recognition (GO:0009988)	5.69354061
19	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	5.69190370
20	calcium ion-dependent exocytosis (GO:0017156)	5.63895344
21	rRNA methylation (GO:0031167)	5.56656690
22	negative regulation of inclusion body assembly (GO:0090084)	5.54467460
23	phosphatidylethanolamine metabolic process (GO:0046337)	5.52857659
24	spermatogenesis (GO:0007283)	5.43487581
25	male gamete generation (GO:0048232)	5.42340494
26	centriole assembly (GO:0098534)	5.35231197
27	sexual reproduction (GO:0019953)	5.28289143
28	protein targeting to Golgi (GO:0000042)	5.20700695
29	protein polyglutamylation (GO:0018095)	5.07379901
30	establishment of protein localization to Golgi (GO:0072600)	4.95541042
31	gamete generation (GO:0007276)	4.95148765
32	regulation of centriole replication (GO:0046599)	4.87213589
33	microtubule severing (GO:0051013)	4.86027482
34	axonemal dynein complex assembly (GO:0070286)	4.79707025
35	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.76273423
36	regulation of cilium movement (GO:0003352)	4.75366230
37	rRNA modification (GO:0000154)	4.71326677
38	positive regulation of Rab GTPase activity (GO:0032851)	4.69857382
39	regulation of Rab GTPase activity (GO:0032313)	4.69857382
40	regulation of transcription involved in cell fate commitment (GO:0060850)	4.17417034
41	motile cilium assembly (GO:0044458)	4.14263157
42	cilium or flagellum-dependent cell motility (GO:0001539)	4.07885365
43	histone H3-K9 demethylation (GO:0033169)	4.05682399
44	single fertilization (GO:0007338)	4.02086307
45	germ cell development (GO:0007281)	3.97363789
46	multicellular organismal reproductive process (GO:0048609)	3.93413379
47	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.93132144
48	cell wall macromolecule catabolic process (GO:0016998)	3.92534108
49	cellular ketone body metabolic process (GO:0046950)	3.91687200
50	nucleus organization (GO:0006997)	3.90651501
51	oxygen transport (GO:0015671)	3.84313905
52	RNA destabilization (GO:0050779)	3.83629827
53	regulation of inclusion body assembly (GO:0090083)	3.82617184
54	chromatin silencing (GO:0006342)	3.77724049
55	cell wall macromolecule metabolic process (GO:0044036)	3.76359029
56	gas transport (GO:0015669)	3.76290919
57	negative regulation of Rho protein signal transduction (GO:0035024)	3.73489683
58	regulation of histone H3-K27 methylation (GO:0061085)	3.66650637
59	regulation of T-helper 2 cell differentiation (GO:0045628)	3.64392600
60	regulation of microtubule-based movement (GO:0060632)	3.57735442
61	glycerol ether metabolic process (GO:0006662)	3.53674725
62	male meiosis (GO:0007140)	3.53152254
63	male meiosis I (GO:0007141)	3.53116962
64	ketone body metabolic process (GO:1902224)	3.52176428
65	peptidyl-threonine dephosphorylation (GO:0035970)	3.50927212
66	protein localization to Golgi apparatus (GO:0034067)	3.49456650
67	fertilization (GO:0009566)	3.48703060
68	protein depolymerization (GO:0051261)	3.45457011
69	DNA methylation involved in gamete generation (GO:0043046)	3.42265385
70	organic cation transport (GO:0015695)	3.40658160
71	DNA conformation change (GO:0071103)	3.39552916
72	nuclear pore complex assembly (GO:0051292)	3.35915397
73	regulation of somitogenesis (GO:0014807)	3.24749241
74	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.22927874
75	ether metabolic process (GO:0018904)	3.20967708
76	histone exchange (GO:0043486)	3.20399691
77	negative regulation of histone methylation (GO:0031061)	3.14155795
78	meiosis I (GO:0007127)	3.11693774
79	musculoskeletal movement (GO:0050881)	3.08730835
80	multicellular organismal movement (GO:0050879)	3.08730835
81	seminiferous tubule development (GO:0072520)	3.04253355
82	piRNA metabolic process (GO:0034587)	3.01333257
83	microtubule nucleation (GO:0007020)	2.98287585
84	peptide catabolic process (GO:0043171)	2.93696220
85	resolution of meiotic recombination intermediates (GO:0000712)	2.93496069
86	synapsis (GO:0007129)	2.93331824
87	NAD biosynthetic process (GO:0009435)	2.89567627
88	response to acidic pH (GO:0010447)	2.87165690
89	Golgi to endosome transport (GO:0006895)	2.84089601
90	coenzyme catabolic process (GO:0009109)	2.83409577
91	polyamine biosynthetic process (GO:0006596)	2.82029485
92	sister chromatid segregation (GO:0000819)	2.80257953
93	homeostasis of number of cells within a tissue (GO:0048873)	2.78261369
94	cellular response to pH (GO:0071467)	2.76932697
95	cerebral cortex neuron differentiation (GO:0021895)	2.76606526
96	mitotic G1 DNA damage checkpoint (GO:0031571)	2.74568971
97	positive regulation of type 2 immune response (GO:0002830)	2.74488204
98	epithelial cilium movement (GO:0003351)	2.68930789
99	acrosome reaction (GO:0007340)	10.9268772
100	fusion of sperm to egg plasma membrane (GO:0007342)	10.3147911

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.42698134
2	FOXM1_23109430_ChIP-Seq_U2OS_Human	4.45633399
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.51168348
4	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.05124616
5	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.80075866
6	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.64163526
7	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.48076670
8	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.42753981
9	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.34000295
10	BCL6_27268052_Chip-Seq_Bcells_Human	2.09818271
11	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.09478836
12	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.09478836
13	RAC3_21632823_ChIP-Seq_H3396_Human	2.06849634
14	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	2.04170665
15	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	2.03829481
16	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.99677507
17	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.95368829
18	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.95117762
19	E2F1_20622854_ChIP-Seq_HELA_Human	1.94373261
20	NANOG_20526341_ChIP-Seq_ESCs_Human	1.94233286
21	ERA_21632823_ChIP-Seq_H3396_Human	1.89744834
22	BCOR_27268052_Chip-Seq_Bcells_Human	1.88656625
23	CBP_20019798_ChIP-Seq_JUKART_Human	1.73335724
24	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.73335724
25	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.69174145
26	P300_27268052_Chip-Seq_Bcells_Human	1.64292531
27	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.63561746
28	RUNX_20019798_ChIP-Seq_JUKART_Human	1.63373968
29	* GATA1_19941826_ChIP-Seq_K562_Human	1.62195837
30	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.62151225
31	SMC4_20622854_ChIP-Seq_HELA_Human	1.61795159
32	SPI1_23127762_ChIP-Seq_K562_Human	1.61721568
33	TAF2_19829295_ChIP-Seq_ESCs_Human	1.61436948
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.60757184
35	MYC_19829295_ChIP-Seq_ESCs_Human	1.59621386
36	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.59466486
37	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.59394472
38	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.57855254
39	OCT4_20526341_ChIP-Seq_ESCs_Human	1.57128787
40	PHF8_20622854_ChIP-Seq_HELA_Human	1.56349919
41	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.53461647
42	RBPJ_21746931_ChIP-Seq_IB4_Human	1.52809904
43	CTCF_20526341_ChIP-Seq_ESCs_Human	1.50642321
44	P68_20966046_ChIP-Seq_HELA_Human	1.49730968
45	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.49237992
46	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.47789930
47	ERG_20517297_ChIP-Seq_VCAP_Human	1.47043956
48	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.44922076
49	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.42760558
50	SPI1_20517297_ChIP-Seq_HL60_Human	1.42637169
51	ER_23166858_ChIP-Seq_MCF-7_Human	1.41679172
52	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.41552193
53	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.40653811
54	VDR_24787735_ChIP-Seq_THP-1_Human	1.40444450
55	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.40243858
56	CEBPB_22108803_ChIP-Seq_LS180_Human	1.37550402
57	LXR_22292898_ChIP-Seq_THP-1_Human	1.36061018
58	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.35280757
59	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.34958115
60	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.34652317
61	ETV1_20927104_ChIP-Seq_GIST48_Human	1.33430158
62	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.33380041
63	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.33267809
64	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.33118689
65	FUS_26573619_Chip-Seq_HEK293_Human	1.32745420
66	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.32420425
67	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.31677488
68	GATA3_26560356_Chip-Seq_TH1_Human	1.30239293
69	TP63_22573176_ChIP-Seq_HFKS_Human	1.29482420
70	SMRT_27268052_Chip-Seq_Bcells_Human	1.26675747
71	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.25782664
72	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.20932777
73	P53_21459846_ChIP-Seq_SAOS-2_Human	1.15649042
74	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.14547197
75	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.14233637
76	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.13862641
77	CTCF_27219007_Chip-Seq_Bcells_Human	1.13152790
78	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	1.13036123
79	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.12166642
80	NFYB_21822215_ChIP-Seq_K562_Human	1.11328700
81	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.11297580
82	* GATA2_19941826_ChIP-Seq_K562_Human	1.10949630
83	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10145899
84	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.10088054
85	PHF8_20622853_ChIP-Seq_HELA_Human	1.08105978
86	STAT1_20625510_ChIP-Seq_HELA_Human	1.07746421
87	MYB_26560356_Chip-Seq_TH2_Human	1.07111908
88	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.06530760
89	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.03987238
90	SA1_27219007_Chip-Seq_Bcells_Human	1.03956154
91	NCOR1_26117541_ChIP-Seq_K562_Human	1.03316188
92	TAF15_26573619_Chip-Seq_HEK293_Human	1.03289949
93	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.03061391
94	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.01439526
95	KLF5_25053715_ChIP-Seq_YYC3_Human	1.00426833
96	DROSHA_22980978_ChIP-Seq_HELA_Human	0.99795213
97	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.98493414
98	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.98230401
99	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.96508994
100	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.96230690

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005377_hearing/vestibular/ear_phenot	6.12830009
2	MP0003878_abnormal_ear_physiology	6.12830009
3	MP0003698_abnormal_male_reproductive	4.04327939
4	MP0001929_abnormal_gametogenesis	3.84889762
5	MP0005670_abnormal_white_adipose	3.41805624
6	MP0002132_abnormal_respiratory_system	3.05416909
7	MP0000678_abnormal_parathyroid_gland	2.84389136
8	MP0002161_abnormal_fertility/fecundity	2.30053298
9	MP0003718_maternal_effect	2.25603421
10	MP0005410_abnormal_fertilization	10.4264170
11	MP0005451_abnormal_body_composition	1.94532055
12	MP0002210_abnormal_sex_determination	1.93152633
13	MP0003011_delayed_dark_adaptation	1.79159556
14	MP0001485_abnormal_pinna_reflex	1.73037446
15	MP0001348_abnormal_lacrimal_gland	1.70168816
16	MP0005310_abnormal_salivary_gland	1.66446105
17	MP0003077_abnormal_cell_cycle	1.63391871
18	MP0001145_abnormal_male_reproductive	1.58992616
19	MP0004957_abnormal_blastocyst_morpholog	1.57140058
20	MP0002138_abnormal_hepatobiliary_system	1.56920331
21	MP0000653_abnormal_sex_gland	1.50795974
22	MP0002282_abnormal_trachea_morphology	1.47725288
23	MP0003724_increased_susceptibility_to	1.45188182
24	MP0003693_abnormal_embryo_hatching	1.33835414
25	MP0003646_muscle_fatigue	1.30637928
26	MP0008995_early_reproductive_senescence	1.29192753
27	MP0003436_decreased_susceptibility_to	1.24032460
28	MP0002234_abnormal_pharynx_morphology	1.23045913
29	MP0004742_abnormal_vestibular_system	1.14302417
30	MP0005397_hematopoietic_system_phenotyp	1.12846775
31	MP0001545_abnormal_hematopoietic_system	1.12846775
32	MP0002249_abnormal_larynx_morphology	1.10511217
33	MP0005248_abnormal_Harderian_gland	1.09721079
34	MP0004510_myositis	1.08270310
35	MP0001835_abnormal_antigen_presentation	1.06922031
36	MP0005083_abnormal_biliary_tract	1.05888780
37	MP0001486_abnormal_startle_reflex	1.05564138
38	MP0009115_abnormal_fat_cell	1.04547709
39	MP0009053_abnormal_anal_canal	1.04537873
40	MP0010094_abnormal_chromosome_stability	1.00711573
41	MP0002419_abnormal_innate_immunity	0.99524452
42	MP0008877_abnormal_DNA_methylation	0.97052119
43	MP0000685_abnormal_immune_system	0.89791594
44	MP0009764_decreased_sensitivity_to	0.88161971
45	MP0009697_abnormal_copulation	0.88070020
46	MP0001765_abnormal_ion_homeostasis	0.86252046
47	MP0009785_altered_susceptibility_to	0.85677514
48	MP0002723_abnormal_immune_serum	0.84281432
49	MP0002127_abnormal_cardiovascular_syste	0.82524972
50	MP0000313_abnormal_cell_death	0.82396891
51	MP0005025_abnormal_response_to	0.81002596
52	MP0001963_abnormal_hearing_physiology	0.80332705
53	MP0001800_abnormal_humoral_immune	0.79489756
54	MP0010307_abnormal_tumor_latency	0.78106826
55	MP0005395_other_phenotype	0.76225301
56	MP0008058_abnormal_DNA_repair	0.75514095
57	MP0002452_abnormal_antigen_presenting	0.74496457
58	MP0003303_peritoneal_inflammation	0.74395953
59	MP0001533_abnormal_skeleton_physiology	0.74103529
60	MP0003950_abnormal_plasma_membrane	0.74085390
61	MP0000015_abnormal_ear_pigmentation	0.71740252
62	MP0002722_abnormal_immune_system	0.70020685
63	MP0000566_synostosis	0.69710624
64	MP0002229_neurodegeneration	0.67747985
65	MP0005666_abnormal_adipose_tissue	0.66799065
66	MP0003111_abnormal_nucleus_morphology	0.66554365
67	MP0003172_abnormal_lysosome_physiology	0.66361777
68	MP0003699_abnormal_female_reproductive	0.65226628
69	MP0002398_abnormal_bone_marrow	0.63065487
70	MP0002420_abnormal_adaptive_immunity	0.62985712
71	MP0005636_abnormal_mineral_homeostasis	0.62242680
72	MP0001819_abnormal_immune_cell	0.61766105
73	MP0001968_abnormal_touch/_nociception	0.60091952
74	MP0009278_abnormal_bone_marrow	0.58899480
75	MP0000026_abnormal_inner_ear	0.58760202
76	MP0005387_immune_system_phenotype	0.58488336
77	MP0001790_abnormal_immune_system	0.58488336
78	MP0000703_abnormal_thymus_morphology	0.58173283
79	MP0004947_skin_inflammation	0.57776871
80	MP0000681_abnormal_thyroid_gland	0.57150894
81	MP0005000_abnormal_immune_tolerance	0.56579019
82	MP0008004_abnormal_stomach_pH	0.54555409
83	MP0006292_abnormal_olfactory_placode	0.53615407
84	MP0000371_diluted_coat_color	0.52991270
85	MP0005464_abnormal_platelet_physiology	0.52924516
86	MP0000716_abnormal_immune_system	0.52250565
87	MP0000249_abnormal_blood_vessel	0.52231837
88	MP0005164_abnormal_response_to	0.50536994
89	MP0002429_abnormal_blood_cell	0.50508739
90	MP0005379_endocrine/exocrine_gland_phen	0.50040080
91	MP0005671_abnormal_response_to	0.49932167
92	MP0002928_abnormal_bile_duct	0.49745245
93	MP0009765_abnormal_xenobiotic_induced	0.47957100
94	MP0003879_abnormal_hair_cell	0.47701391
95	MP0001119_abnormal_female_reproductive	0.47301778
96	MP0008469_abnormal_protein_level	0.47097707
97	MP0005253_abnormal_eye_physiology	0.46664715
98	MP0002405_respiratory_system_inflammati	0.46578149
99	MP0003828_pulmonary_edema	0.46254390
100	MP0005551_abnormal_eye_electrophysiolog	0.45596744

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	7.56464808
2	Absent/shortened dynein arms (HP:0200106)	5.10212756
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.10212756
4	Tubulointerstitial nephritis (HP:0001970)	4.72509969
5	Asymmetric septal hypertrophy (HP:0001670)	4.62908873
6	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	4.41579448
7	Attenuation of retinal blood vessels (HP:0007843)	4.39314777
8	Nasal polyposis (HP:0100582)	4.33407467
9	Aplasia/Hypoplasia of the earlobes (HP:0009906)	4.28511077
10	Bell-shaped thorax (HP:0001591)	4.13870739
11	Bony spicule pigmentary retinopathy (HP:0007737)	4.05966077
12	Resting tremor (HP:0002322)	4.00478027
13	Male infertility (HP:0003251)	3.90284568
14	Abnormal ciliary motility (HP:0012262)	3.78607830
15	Abnormal respiratory motile cilium physiology (HP:0012261)	3.57862339
16	Cone-rod dystrophy (HP:0000548)	3.55926261
17	Hypoplastic ischia (HP:0003175)	3.50882782
18	Abnormality of macular pigmentation (HP:0008002)	3.38408870
19	Hyperkalemia (HP:0002153)	3.37427378
20	Abnormal respiratory epithelium morphology (HP:0012253)	3.29495720
21	Abnormal respiratory motile cilium morphology (HP:0005938)	3.29495720
22	Abnormality of the nasal mucosa (HP:0000433)	3.29045462
23	Enlarged epiphyses (HP:0010580)	3.26650186
24	Abnormal rod and cone electroretinograms (HP:0008323)	3.24233132
25	Chronic hepatic failure (HP:0100626)	3.13805386
26	Infertility (HP:0000789)	3.11585016
27	Abnormal spermatogenesis (HP:0008669)	3.08593457
28	Impulsivity (HP:0100710)	3.02877264
29	Abnormality of the ischium (HP:0003174)	2.97373490
30	Azoospermia (HP:0000027)	2.93638370
31	Abnormal hemoglobin (HP:0011902)	2.90138838
32	Facial shape deformation (HP:0011334)	2.80561168
33	Potter facies (HP:0002009)	2.80561168
34	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.78375705
35	Postural instability (HP:0002172)	2.77389241
36	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.72228659
37	Hypochromic microcytic anemia (HP:0004840)	2.66058008
38	Flattened epiphyses (HP:0003071)	2.62386818
39	Small intestinal stenosis (HP:0012848)	2.51864784
40	Duodenal stenosis (HP:0100867)	2.51864784
41	Obstructive lung disease (HP:0006536)	2.46135786
42	Chronic obstructive pulmonary disease (HP:0006510)	2.46135786
43	Amelogenesis imperfecta (HP:0000705)	2.42449824
44	Abnormality of the costochondral junction (HP:0000919)	2.37935103
45	Absent epiphyses (HP:0010577)	2.36213100
46	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.36213100
47	Gastrointestinal infarctions (HP:0005244)	2.33753820
48	Truncal obesity (HP:0001956)	2.31844225
49	Osteomalacia (HP:0002749)	2.31252456
50	Hypoplasia of the thymus (HP:0000778)	2.29640097
51	Recurrent pneumonia (HP:0006532)	2.29298868
52	Abnormality of macrophages (HP:0004311)	2.26111933
53	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.25062028
54	Aplasia/Hypoplasia of the thymus (HP:0010515)	2.21053965
55	Tetany (HP:0001281)	2.19839875
56	Hypoparathyroidism (HP:0000829)	2.19174117
57	Hypertensive crisis (HP:0100735)	2.18436656
58	Hyperthyroidism (HP:0000836)	2.16446220
59	Bowel incontinence (HP:0002607)	2.11519233
60	Hypoalphalipoproteinemia (HP:0003233)	2.10398900
61	Generalized aminoaciduria (HP:0002909)	2.08889415
62	Gingivitis (HP:0000230)	2.08781702
63	Menstrual irregularities (HP:0000858)	2.08265920
64	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.06117321
65	Abnormality of dental color (HP:0011073)	2.05195096
66	Abnormal large intestine physiology (HP:0012700)	2.02581289
67	Atelectasis (HP:0100750)	2.01791462
68	Decreased central vision (HP:0007663)	1.99328592
69	Tubulointerstitial abnormality (HP:0001969)	1.99071446
70	Progressive sensorineural hearing impairment (HP:0000408)	1.98992441
71	Recurrent bacterial skin infections (HP:0005406)	1.95484033
72	Portal hypertension (HP:0001409)	1.95140005
73	Recurrent abscess formation (HP:0002722)	1.94241475
74	Truncus arteriosus (HP:0001660)	1.92518857
75	Abnormality of the duodenum (HP:0002246)	1.89733856
76	Abnormal urine output (HP:0012590)	1.88843533
77	Vertebral clefting (HP:0008428)	1.88515015
78	Unilateral renal agenesis (HP:0000122)	1.88117726
79	Epiphyseal dysplasia (HP:0002656)	1.87890644
80	Abnormality of the preputium (HP:0100587)	1.86332885
81	Reticulocytosis (HP:0001923)	1.85015595
82	Widely patent fontanelles and sutures (HP:0004492)	1.84866312
83	Protuberant abdomen (HP:0001538)	1.84827631
84	Congenital malformation of the right heart (HP:0011723)	1.84682151
85	Double outlet right ventricle (HP:0001719)	1.84682151
86	Abnormality of DNA repair (HP:0003254)	1.84190859
87	Short ribs (HP:0000773)	1.83159592
88	Retrobulbar optic neuritis (HP:0100654)	1.83030023
89	Optic neuritis (HP:0100653)	1.83030023
90	Rhinitis (HP:0012384)	1.82988742
91	Horizontal nystagmus (HP:0000666)	1.81138578
92	Prolonged bleeding time (HP:0003010)	1.80701878
93	Upper limb muscle weakness (HP:0003484)	1.77501554
94	Abnormality of the hepatic vasculature (HP:0006707)	1.76259034
95	Seborrheic dermatitis (HP:0001051)	1.75710417
96	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.73836533
97	Abnormality of potassium homeostasis (HP:0011042)	1.73793402
98	Chromsome breakage (HP:0040012)	1.73440088
99	Abnormality of the epiphysis of the femoral head (HP:0010574)	1.73152874
100	Optic nerve hypoplasia (HP:0000609)	1.71367222

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	8.17564967
2	TESK1	4.67598854
3	PNCK	4.57484084
4	DDR2	4.03330484
5	INSRR	3.20999547
6	RIPK4	2.86988221
7	PLK2	2.51829124
8	MST1R	2.50206716
9	BRD4	2.44882859
10	STK38	2.43387270
11	KSR2	2.19670940
12	BUB1	2.17349252
13	MAP4K2	2.15465318
14	CAMK1G	1.80496170
15	CDK12	1.73852218
16	MAP3K2	1.73268561
17	PTK2B	1.73145357
18	MAPK15	1.72737082
19	WNK1	1.64956372
20	WEE1	1.57641470
21	CCNB1	1.48085331
22	PDPK1	1.30630288
23	CDK7	1.29929071
24	PDK1	1.26966971
25	STK38L	1.24421086
26	MET	1.22454101
27	PIK3CG	1.21013040
28	BLK	1.17891398
29	NEK1	1.16973157
30	NEK2	1.16823432
31	BRAF	1.15045430
32	BRSK2	1.14054139
33	PRKD3	1.05212865
34	TESK2	1.03221668
35	BRSK1	1.01957468
36	MAP3K8	1.01267203
37	DYRK1B	0.86723010
38	MARK3	0.85343722
39	NEK6	0.82578642
40	JAK3	0.70753381
41	IRAK4	0.68336775
42	KSR1	0.64171135
43	MAP3K3	0.61358921
44	RPS6KA1	0.61256672
45	EIF2AK1	0.60841745
46	PRKG2	0.60573647
47	RAF1	0.60322735
48	PLK1	0.58899463
49	ARAF	0.57611666
50	TNK2	0.55623500
51	JAK2	0.54784783
52	MAP3K1	0.53562740
53	TTK	0.52369009
54	STK10	0.49578808
55	CSF1R	0.49576408
56	WNK4	0.48825314
57	BMX	0.47471410
58	PRKG1	0.46922116
59	MAP2K3	0.45853419
60	CSK	0.44614569
61	UHMK1	0.42519864
62	CAMK1D	0.42123843
63	CDK1	0.39279926
64	SYK	0.38965113
65	FGR	0.38834071
66	MAP3K11	0.38428674
67	MAP3K7	0.36737900
68	ROCK1	0.36231433
69	CHEK1	0.35753488
70	CDK4	0.35604056
71	HCK	0.35323840
72	GRK6	0.35260924
73	TYK2	0.34962644
74	CDK2	0.34919626
75	PRKAA2	0.34670143
76	SIK2	0.34510985
77	RPS6KA2	0.33162768
78	RPS6KC1	0.32892650
79	RPS6KL1	0.32892650
80	TAOK1	0.32479001
81	MAPK1	0.30969716
82	NTRK3	0.29944620
83	DYRK3	0.28657054
84	RPS6KA6	0.28180879
85	MUSK	0.27414420
86	YES1	0.26232820
87	AKT3	0.25099718
88	RET	0.24416349
89	PLK3	0.21093871
90	RIPK1	0.19769280
91	IKBKB	0.19047130
92	STK3	0.18835825
93	SGK1	0.17657155
94	CDK19	0.17493574
95	GSK3B	0.17145132
96	STK39	0.16010483
97	OXSR1	0.15880430
98	BMPR2	0.15837895
99	PRKCZ	0.15753657
100	LATS1	0.14431181

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fatty acid biosynthesis_Homo sapiens_hsa00061	5.48319248
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	5.02208380
3	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	3.16933462
4	Olfactory transduction_Homo sapiens_hsa04740	2.85972224
5	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.24050679
6	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.11660947
7	Allograft rejection_Homo sapiens_hsa05330	2.09020197
8	Antigen processing and presentation_Homo sapiens_hsa04612	2.00200774
9	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.98258673
10	Graft-versus-host disease_Homo sapiens_hsa05332	1.98045232
11	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.94550146
12	Acute myeloid leukemia_Homo sapiens_hsa05221	1.91866913
13	Type II diabetes mellitus_Homo sapiens_hsa04930	1.89888403
14	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.88574605
15	Influenza A_Homo sapiens_hsa05164	1.76501700
16	RNA transport_Homo sapiens_hsa03013	1.68261733
17	Type I diabetes mellitus_Homo sapiens_hsa04940	1.64259706
18	Oocyte meiosis_Homo sapiens_hsa04114	1.61677503
19	Leishmaniasis_Homo sapiens_hsa05140	1.60950115
20	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.56388178
21	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.44880724
22	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.44022254
23	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.43716596
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.42270712
25	Viral myocarditis_Homo sapiens_hsa05416	1.39562182
26	Osteoclast differentiation_Homo sapiens_hsa04380	1.38047751
27	Legionellosis_Homo sapiens_hsa05134	1.33719966
28	Butanoate metabolism_Homo sapiens_hsa00650	1.21096231
29	Herpes simplex infection_Homo sapiens_hsa05168	1.20989059
30	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.20514373
31	Cell cycle_Homo sapiens_hsa04110	1.06608730
32	Measles_Homo sapiens_hsa05162	1.06529230
33	Endocytosis_Homo sapiens_hsa04144	1.05444522
34	VEGF signaling pathway_Homo sapiens_hsa04370	1.04927417
35	Viral carcinogenesis_Homo sapiens_hsa05203	1.04326707
36	Malaria_Homo sapiens_hsa05144	0.98038014
37	Toxoplasmosis_Homo sapiens_hsa05145	0.96582167
38	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.95313150
39	Non-small cell lung cancer_Homo sapiens_hsa05223	0.94625289
40	Chemokine signaling pathway_Homo sapiens_hsa04062	0.93119802
41	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.92234755
42	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.88664329
43	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.87343781
44	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.86078461
45	Taste transduction_Homo sapiens_hsa04742	0.85613074
46	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.81355461
47	Mismatch repair_Homo sapiens_hsa03430	0.80798612
48	Prolactin signaling pathway_Homo sapiens_hsa04917	0.78755073
49	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.78063134
50	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.76801350
51	Fatty acid metabolism_Homo sapiens_hsa01212	0.76390560
52	Tuberculosis_Homo sapiens_hsa05152	0.75275716
53	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.74677390
54	Estrogen signaling pathway_Homo sapiens_hsa04915	0.73863639
55	Prostate cancer_Homo sapiens_hsa05215	0.72968368
56	Fatty acid degradation_Homo sapiens_hsa00071	0.66585951
57	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.66414873
58	Homologous recombination_Homo sapiens_hsa03440	0.65148488
59	Hepatitis B_Homo sapiens_hsa05161	0.63146328
60	mRNA surveillance pathway_Homo sapiens_hsa03015	0.59239225
61	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.58704350
62	Phenylalanine metabolism_Homo sapiens_hsa00360	0.56597937
63	ABC transporters_Homo sapiens_hsa02010	0.56572905
64	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.56292260
65	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.53544639
66	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.53465904
67	Basal transcription factors_Homo sapiens_hsa03022	0.53201407
68	ErbB signaling pathway_Homo sapiens_hsa04012	0.52230881
69	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.49879391
70	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.49417665
71	Pancreatic cancer_Homo sapiens_hsa05212	0.48953058
72	Choline metabolism in cancer_Homo sapiens_hsa05231	0.48734494
73	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.47659489
74	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.46972970
75	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.44810868
76	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.44188385
77	mTOR signaling pathway_Homo sapiens_hsa04150	0.42913703
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.42563565
79	Regulation of autophagy_Homo sapiens_hsa04140	0.41832115
80	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.40773522
81	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.40405207
82	African trypanosomiasis_Homo sapiens_hsa05143	0.40236969
83	MAPK signaling pathway_Homo sapiens_hsa04010	0.39862457
84	FoxO signaling pathway_Homo sapiens_hsa04068	0.39854955
85	TNF signaling pathway_Homo sapiens_hsa04668	0.39843387
86	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.39547009
87	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.39340824
88	Platelet activation_Homo sapiens_hsa04611	0.38604265
89	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.38062820
90	Selenocompound metabolism_Homo sapiens_hsa00450	0.38046403
91	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.37946797
92	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.37649291
93	Base excision repair_Homo sapiens_hsa03410	0.36639268
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.36520881
95	Mineral absorption_Homo sapiens_hsa04978	0.35166316
96	cAMP signaling pathway_Homo sapiens_hsa04024	0.35091309
97	Renal cell carcinoma_Homo sapiens_hsa05211	0.34803957
98	Endometrial cancer_Homo sapiens_hsa05213	0.32122010
99	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.31979763
100	Phagosome_Homo sapiens_hsa04145	0.31595893

NT5DC4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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